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  1. Content type: Research

    To report our experience in planning and delivering total marrow irradiation (TMI) and total marrow and lymphatic irradiation (TMLI) in patients with hematologic malignancies.

    Authors: Zhirong Bao, Hongli Zhao, Dajiang Wang, Jian Gong, Yahua Zhong, Yu Xiong, Di Deng, Conghua Xie, An Liu, Xiaoyong Wang and Hui Liu

    Citation: Radiation Oncology 2018 13:248

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  2. Content type: Research

    Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether treatment outcomes of cervical adenocarcinoma are equivalent to SC...

    Authors: Ke Hu, Weiping Wang, Xiaoliang Liu, Qingyu Meng and Fuquan Zhang

    Citation: Radiation Oncology 2018 13:249

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  3. Content type: Research

    The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with e...

    Authors: Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Daisuke Shimizu, Takuya Kimoto, Atsushi Shiozaki, Osamu Dohi, Hitoshi Fujiwara, Takeshi Ishikawa, Hirotaka Konishi, Yuji Naito, Eigo Otsuji and Kei Yamada

    Citation: Radiation Oncology 2018 13:246

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  4. Content type: Research

    The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and af...

    Authors: Yu Yang Soon, Huili Zheng, Shaun Zhirui Ho, Wee Yao Koh, Cheng Nang Leong, Jeremy Chee Seong Tey, Balamurugan Vellayappan, Swee Peng Yap, Ivan Weng Keong Tham and Kam Weng Fong

    Citation: Radiation Oncology 2018 13:247

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  5. Content type: Research

    Oesophageal cancer with airway invasion presents a challenge for therapy and often has serious complications. We analysed the clinical outcomes of radiation therapy (RT) in patients with clinical T4b oesophage...

    Authors: Hakyoung Kim, Dongryul Oh, Yong Chan Ahn, Keunchil Park, Myung-Ju Ahn, Se-Hoon Lee, Jong-Mu Sun, Young Mog Shim, Jae Ill Zo, Yong Soo Choi, Hong Kwan Kim and Jong Ho Cho

    Citation: Radiation Oncology 2018 13:245

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  6. Content type: Research

    Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, ...

    Authors: Verónica García-Vázquez, Begoña Sesé-Lucio, Felipe A. Calvo, Juan J. Vaquero, Manuel Desco and Javier Pascau

    Citation: Radiation Oncology 2018 13:243

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  7. Content type: Research

    Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers...

    Authors: Marc Ziegler, Tobias Brandt, Sebastian Lettmaier, Rainer Fietkau and Christoph Bert

    Citation: Radiation Oncology 2018 13:242

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  8. Content type: Research

    Automatic multi-criteria optimization is necessary for intensity modulated radiation therapy (IMRT) because of low planning efficiency and large plan quality uncertainty in current clinical practice. Most stud...

    Authors: Yanhua Mai, Fantu Kong, Yiwei Yang, Linghong Zhou, Yongbao Li and Ting Song

    Citation: Radiation Oncology 2018 13:241

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  9. Content type: Research

    Advanced clinical applications, such as dose accumulation and adaptive radiation therapy, require deformable image registration (DIR) algorithms capable of voxel-wise accurate mapping of treatment dose or func...

    Authors: An Qin, Dan Ionascu, Jian Liang, Xiao Han, Nicolette O’Connell and Di Yan

    Citation: Radiation Oncology 2018 13:240

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  10. Content type: Research

    Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (I...

    Authors: Hendrik Dapper, Iván Rodríguez, Stefan Münch, Jan C. Peeken, Kai Borm, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:237

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  11. Content type: Research

    Peer review systems within radiation oncology are important to ensure quality radiation care. Several individualized methods for radiation oncology peer review have been described. However, despite the importa...

    Authors: Ashley A. Albert, William N. Duggar, Rahul P. Bhandari, Toms Vengaloor Thomas, Satyaseelan Packianathan, Robert M. Allbright, Madhava R. Kanakamedala, Divyang Mehta, Chunli Claus Yang and Srinivasan Vijayakumar

    Citation: Radiation Oncology 2018 13:239

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  12. Content type: Research

    Volumetric shrinkage of normal tissues such as salivary glands, kidneys, hippocampus are observed after radiotherapy. We aimed to assess the alterations in pancreatic volume of patients who received abdominal ...

    Authors: Cengiz Gemici, Gokhan Yaprak, Sevim Ozdemir, Tamer Baysal, Ozgur Ozan Seseogullari and Hazan Ozyurt

    Citation: Radiation Oncology 2018 13:238

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  13. Content type: Research

    To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advance...

    Authors: Pei-Chieh Yu, Ching-Jung Wu, Hsin-Hua Nien, Louis Tak Lui, Suzun Shaw and Yu-Lun Tsai

    Citation: Radiation Oncology 2018 13:236

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  14. Content type: Research

    To compare the clinical outcome in prostate cancer patients treated with radiotherapy using two forms of image guidance: bone-based (BB) or fiducial-based (FB).

    Authors: Aleksandra Napieralska, Wojciech Majewski, Roland Kulik, Grzegorz Głowacki and Leszek Miszczyk

    Citation: Radiation Oncology 2018 13:235

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  15. Content type: Research

    The aim of this study was to evaluate long-term efficacy and survival prognostic factors of stereotactic body radiation therapy (SBRT) for un-resectable liver metastases in patients enrolled in a prospective p...

    Authors: Marta Scorsetti, Tiziana Comito, Elena Clerici, Ciro Franzese, Angelo Tozzi, Cristina Iftode, Lucia Di Brina, Pierina Navarria, Pietro Mancosu, Giacomo Reggiori, Antonella Fogliata, Stefano Tomatis, Guido Torzilli and Luca Cozzi

    Citation: Radiation Oncology 2018 13:234

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  16. Content type: Research

    The usefulness of particle therapy for skull base chordoma has not been established. The aim of this retrospective study was to analyse the treatment outcomes of proton therapy (PT) and carbon ion therapy (CIT...

    Authors: Masaru Takagi, Yusuke Demizu, Fumiko Nagano, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Masayuki Mima, Yasue Niwa, Kuniaki Katsui, Masaki Suga, Tomohiro Yamashita, Takashi Akagi, Koh-ichi Sakata, Nobukazu Fuwa and Tomoaki Okimoto

    Citation: Radiation Oncology 2018 13:232

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  17. Content type: Research

    Tangent-based intensity modulated radiation therapy (TIMRT) is a common adjuvant radiotherapy strategy for breast cancer patients. This study compared the dosimetric characteristics of tangent-based volumetric...

    Authors: Pei-Chieh Yu, Ching-Jung Wu, Yu-Lun Tsai, Suzun Shaw, Shih-Yu Sung, Louis Tak Lui and Hsin-Hua Nien

    Citation: Radiation Oncology 2018 13:231

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  18. Content type: Research

    The purpose of this study is to compare the efficacy and safety of concurrent chemoradiotherapy (CCRT) versus chemotherapy alone for patients with stage IV esophageal squamous cell carcinoma (ESCC).

    Authors: Jiahua Lyu, Tao Li, Qifeng Wang, Fang Li, Peng Diao, Li Liu, Churong Li and Jinyi Lang

    Citation: Radiation Oncology 2018 13:233

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  19. Content type: Research

    A new strategy is introduced combining the use of Multi-Criteria Optimization-based Trade-Off Exploration (TO) and RapidPlan™ (RP) for the selection of optimisation parameters that improve the trade-off betwee...

    Authors: Eliane Miguel-Chumacero, Garry Currie, Abigail Johnston and Suzanne Currie

    Citation: Radiation Oncology 2018 13:229

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  20. Content type: Research

    To evaluate the treatment outcome and prostate-specific antigen (PSA) change after stereotactic body radiotherapy (SBRT) for localized prostate cancer.

    Authors: Younghee Park, Hae Jin Park, Won Il Jang, Bae Kwon Jeong, Hun-Jung Kim and Ah Ram Chang

    Citation: Radiation Oncology 2018 13:230

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  21. Content type: Research

    Neoadjuvant radio(chemo)therapy of non-metastasized, borderline resectable or unresectable locally advanced pancreatic cancer is complex and prone to cause side-effects, e.g., in gastrointestinal organs. Inten...

    Authors: Sarah Stefanowicz, Kristin Stützer, Sebastian Zschaeck, Annika Jakobi and Esther G. C. Troost

    Citation: Radiation Oncology 2018 13:228

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  22. Content type: Research

    The ano-inguinal lymphatic drainage (AILD) is located in the subcutaneous adipose tissue of the proximal medial thigh. Currently, there are no recommendations for an inclusion of the ‘true’ AILD in the clinica...

    Authors: Hendrik Dapper, Markus Oechsner, Christoph Hirche, Stefan Münch, Christina Sauter, Kai Borm, Jan C. Peeken, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:227

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  23. Content type: Research

    Patients with recurrent retroperitoneal and pelvic region tumors often require multimodal therapies. Intraoperative radiation therapy (IORT) can deliver high-dose radiation to tumor beds, even if first-line ex...

    Authors: Tharcisio Machado Coelho, Ricardo César Fogaroli, Antonio Cassio Assis Pellizzon, Douglas Guedes De Castro, Guilherme Rocha Melo Gondim, Maria Leticia Gobo Silva, Michael Jenwei Chen and Henderson Ramos

    Citation: Radiation Oncology 2018 13:224

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  24. Content type: Research

    Currently, the standard treatment for locally advanced cervical cancer patients is concurrent chemoradiotherapy. Here we aim to evaluate therapeutic efficacy, treatment failure, toxicity and prognostic factors...

    Authors: Qingyu Meng, Weiping Wang, Xiaoliang Liu, Xiaorong Hou, Xin Lian, Shuai Sun, Junfang Yan, Zhikai Liu, Zheng Miao, Ke Hu and Fuquan Zhang

    Citation: Radiation Oncology 2018 13:223

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  25. Content type: Correction

    Following publication of the original article [1], the authors reported that one of the authors’ names was processed incorrectly.

    Authors: J. Krayenbuehl, M. Zamburlini, S. Ghandour, M. Pachoud, S. Tanadini-Lang, J. Tol, M. Guckenberger and W. F. A. R. Verbakel

    Citation: Radiation Oncology 2018 13:225

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    The original article was published in Radiation Oncology 2018 13:170

  26. Content type: Research

    Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently availab...

    Authors: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio and Panu M. Jaakkola

    Citation: Radiation Oncology 2018 13:220

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  27. Content type: Research

    It has been reported that proximity of the tumor to the optic disc and macula, and radiation dose to the critical structures are substantial risk factors for vision loss following plaque brachytherapy. However...

    Authors: Yongsook C. Lee, Shih-Chi Lin and Yongbok Kim

    Citation: Radiation Oncology 2018 13:221

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  28. Content type: Research

    The dosimetric leaf gap (DLG) and multileaf collimator (MLC) transmission are two important systematic parameters used to model the rounded MLC leaf ends effect when commissioning an Eclipse treatment planning...

    Authors: Chih-Yuan Lin, An-Cheng Shiau, Jin-Huei Ji, Chia-Jung Lee, Ti-Hao Wang, Shu-Hui Hsu and Ji-An Liang

    Citation: Radiation Oncology 2018 13:222

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  29. Content type: Research

    To propose an easily applicable segmentation method (perPET-RT) for delineation of tumour volume during radiotherapy on interim fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomogr...

    Authors: J. Ganem, S. Thureau, I. Gardin, R. Modzelewski, S. Hapdey and P. Vera

    Citation: Radiation Oncology 2018 13:219

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  30. Content type: Research

    This study was performed to evaluate skin toxicity during modern three-dimensional conformal radiotherapy (3D-CRT) and to evaluate the importance of dose distribution and patient related factors.

    Authors: Kai J. Borm, Maximilian Loos, Markus Oechsner, Michael C. Mayinger, Daniela Paepke, Marion B. Kiechle, Stephanie E. Combs and Marciana N. Duma

    Citation: Radiation Oncology 2018 13:218

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  31. Content type: Research

    Cancer cachexia is a prevalent symptom of head and neck neoplasms. The reduction in skeletal muscle mass is one of the main characteristics which can lead to poor physical functioning. The purposes of this pil...

    Authors: Manuel Grote, Cornelius Maihöfer, Martin Weigl, Patricia Davies-Knorr and Claus Belka

    Citation: Radiation Oncology 2018 13:215

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  32. Content type: Research

    Dose escalation of conventionally fractionated radiation therapy (CFRT) above 45–54 Gy has an unclear survival benefit. Prior National Cancer Database (NCDB) analyses have shown improved overall survival with ...

    Authors: Sung Jun Ma, Kavitha M. Prezzano, Gregory M. Hermann and Anurag K. Singh

    Citation: Radiation Oncology 2018 13:214

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  33. Content type: Research

    A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and together with the platelet-to-lymphocyte ratio (PLR) is associated with worse outcomes in several solid tumors. We investiga...

    Authors: Beat Bojaxhiu, Arnoud J. Templeton, Olgun Elicin, Mohamed Shelan, Kathrin Zaugg, Marc Walser, Roland Giger, Daniel M. Aebersold and Alan Dal Pra

    Citation: Radiation Oncology 2018 13:216

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  34. Content type: Research

    To determine the prognostic impact of comorbidity and age in medically inoperable early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT) using the age-adjusted Charls...

    Authors: Julia Dreyer, Michael Bremer and Christoph Henkenberens

    Citation: Radiation Oncology 2018 13:213

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  35. Content type: Research

    This was a prespecified secondary analysis of a randomized trial that analyzed bone density and pain response following fractionated intensity-modulated radiotherapy (IMRT) versus three-dimensional conformal r...

    Authors: Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus and Harald Rief

    Citation: Radiation Oncology 2018 13:212

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  36. Content type: Research

    [18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) may be used for tumor staging and prognosis in several tumors but its role in rectal cancer is still debated. The ai...

    Authors: Letizia Deantonio, Angela Caroli, Erinda Puta, Daniela Ferrante, Francesco Apicella, Lucia Turri, Gianmauro Sacchetti, Marco Brambilla and Marco Krengli

    Citation: Radiation Oncology 2018 13:211

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  37. Content type: Research

    To evaluate long-term IPSS score and urinary quality of life after radiotherapy for prostate cancer, in patients with prior history of surgical treatment for benign prostatic hyperplasia (BPH).

    Authors: Mélanie Guilhen, Christophe Hennequin, Idir Ouzaid, Ingrid Fumagalli, Valentine Martin, Sophie Guillerm, Pierre Mongiat-Artus, Vincent Ravery, François Desgrandchamps and Laurent Quéro

    Citation: Radiation Oncology 2018 13:209

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  38. Content type: Research

    HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.

    Authors: Ning Li, Dan-dan Meng, Ling Gao, Yue Xu, Pei-jie Liu, Yong-wei Tian, Zhen-ying Yi, Yan Zhang, Xiao-jing Tie and Zhi-qiao Xu

    Citation: Radiation Oncology 2018 13:210

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  39. Content type: Research

    Concomitant chemo-radiotherapy is the reference treatment for non-resectable locally-advanced Non-Small Cell Lung Cancer (NSCLC). Increasing radiotherapy total dose in the whole tumour volume has been shown to...

    Authors: Sébastien Thureau, Bernard Dubray, Romain Modzelewski, Pierre Bohn, Sébastien Hapdey, Sabine Vincent, Elodie Anger, David Gensanne, Nicolas Pirault, Gouel Pierrick and Pierre Vera

    Citation: Radiation Oncology 2018 13:208

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  40. Content type: Research

    The aim of our study was to evaluate feasibility, toxicity profile and local control of salvage intensity modulated radiotherapy (IMRT) delivered with simultaneous integrated boost (SIB) associated or not to c...

    Authors: L. Nicosia, L. Agolli, C. Reverberi, V. De Sanctis, L. Marinelli, G. Minniti, J. Di Muzio, M. Valeriani and M. F. Osti

    Citation: Radiation Oncology 2018 13:207

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  41. Content type: Research

    Radiotherapy of liver metastases is commonly being performed with photon-beam based stereotactic body radiation therapy (SBRT). The high risk for radiation-induced liver disease (RILD) is a limiting factor in ...

    Authors: Gracinda Mondlane, Ana Ureba, Michael Gubanski, P A Lind and Albert Siegbahn

    Citation: Radiation Oncology 2018 13:206

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  42. Content type: Research

    To assess the efficacy and safety of stereotactic body radiation therapy (SBRT) in the management of adrenal gland metastases (AGMs) from lung cancer. Moreover, it is the first two-institutional experience and...

    Authors: Xianzhi Zhao, Xiaofei Zhu, Jianfeng Fei, Haipeng Ren, Yangsen Cao, Xiaoping Ju, Zhiyong Yuan and Huojun Zhang

    Citation: Radiation Oncology 2018 13:205

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  43. Content type: Research

    Stereotactic ablative radiotherapy (SABR) offers an alternative treatment for pancreatic cancer, with the potential for improved tumour control and reduced toxicity compared with conventional therapies. Howeve...

    Authors: Christy Goldsmith, P. Nicholas Plowman, Melanie M. Green, Roger G. Dale and Patricia M. Price

    Citation: Radiation Oncology 2018 13:204

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  44. Content type: Research

    Technological advances in Hodgkin lymphoma (HL) radiation therapy (RT) by high conformal treatments potentially increase control over organs-at-risk (OARs) dose distribution. However, plan optimization remains...

    Authors: Stefania Clemente, Caterina Oliviero, Giuseppe Palma, Vittoria D’Avino, Raffaele Liuzzi, Manuel Conson, Roberto Pacelli and Laura Cella

    Citation: Radiation Oncology 2018 13:202

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  45. Content type: Research

    Radiation-induced heart disease is mainly caused by activation of the fibrotic process. Transforming growth factor-beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are pro-fibrotic mediators. The aim ...

    Authors: Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: Radiation Oncology 2018 13:201

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  46. Content type: Research

    Computed tomography (CT) data used for patient radiotherapy planning can nowadays be used to create 3D-printed boluses. Nevertheless, this methodology requires a second CT scan and planning process when immobi...

    Authors: Giovanna Dipasquale, Alexis Poirier, Yannick Sprunger, Johannes Wilhelmus Edmond Uiterwijk and Raymond Miralbell

    Citation: Radiation Oncology 2018 13:203

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  47. Content type: Research

    The prognostic value of supra-clavicular lymph node (SCLN) metastases in esophageal cancer (EC) is still not clear.

    Authors: Hong-Yao Xu, Sheng-Xi Wu, He-San Luo, Chu-Yun Chen, Lian-Xing Lin and He-Cheng Huang

    Citation: Radiation Oncology 2018 13:200

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