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  1. Content type: Research

    We evaluated the long-term outcomes and late toxicity of conventional fractionated (CF) and hypofractionated (HF) postmastectomy radiotherapy (PMRT) in terms of locoregional recurrence-free survival (LRRFS), d...

    Authors: Imjai Chitapanarux, Pitchayaponne Klunklin, Attapol Pinitpatcharalert, Patumrat Sripan, Ekkasit Tharavichitkul, Wannapha Nobnop, Wimrak Onchan, Somvilai Chakrabandhu, Bongkot Jia-Mahasap, Juntima Euathrongchit, Yutthaphan Wannasopha and Tanop Srisuwan

    Citation: Radiation Oncology 2019 14:175

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  2. Content type: Research

    This study aimed to evaluate the clinical and dosimetric factors predictive of acute anal toxicity (AAT) after radiotherapy in prostate cancer (PCa) patients with or without hemorrhoids.

    Authors: Xingsi Peng, Sha Zhou, Shiliang Liu, Jibin Li, Sijuan Huang, Xiaobo Jiang, Maosheng Lin, Shaomin Huang, Chengguang Lin, Chaonan Qian, Mengzhong Liu and Liru He

    Citation: Radiation Oncology 2019 14:174

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  3. Content type: Research

    Ultrasound (US) imaging has been proved as an excellent diagnostic tool in gynecology and, due to its wide availability and limited cost, is under intense investigation as base for dose adaptation in cervical ...

    Authors: Mario Federico, Carmen Rosa Hernandez-Socorro, Ivone Ribeiro, Jesus Gonzalez Martin, Maria Dolores Rey-Baltar Oramas, Marta Lloret Saez-Bravo and Pedro Carlos Lara Jimenez

    Citation: Radiation Oncology 2019 14:173

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  4. Content type: Research

    Vendor-independent Monte Carlo (MC) dose calculation (IDC) for patient-specific quality assurance of multi-leaf collimator (MLC) based CyberKnife treatments is used to benchmark and validate the commercial MC ...

    Authors: P.-H. Mackeprang, D. Vuong, W. Volken, D. Henzen, D. Schmidhalter, M. Malthaner, S. Mueller, D. Frei, W. Kilby, D. M. Aebersold, M. K. Fix and P. Manser

    Citation: Radiation Oncology 2019 14:172

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  5. Content type: Research

    Prophylactic cranial irradiation (PCI) is indicated for limited-stage small cell lung cancer (LS-SCLC) with good response to chemoradiotherapy (CRT). However, brain metastasis (BM) developed in LS-SCLC before ...

    Authors: Xiao Chu, Shuyan Li, Bingqing Xia, Li Chu, Xi Yang, Jianjiao Ni, Liqing Zou, Yida Li, Congying Xie, Jie Lin and Zhengfei Zhu

    Citation: Radiation Oncology 2019 14:171

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  6. Content type: Research

    Pathogenesis of brain metastases/meningeal cancer and the emotional and neurological outcomes are not yet well understood. The hypothesis of our study is that patients with leptomeningeal cancer show volumetri...

    Authors: Michael Mayinger, Antonia Reibelt, Kai Joachim Borm, Johannes Ettl, Jan J. Wilkens, Stephanie Elisabeth Combs, Markus Oechsner and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:170

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  7. Content type: Research

    Leptomeningeal metastasis (LM) is a devastating and terminal complication of advanced non-small-cell lung cancer (NSCLC), especially in patients harboring epidermal growth factor receptor (EGFR) mutations. The...

    Authors: Weiwei Yan, Yang Liu, Ji Li, Anqin Han, Li Kong, Jinming Yu and Hui Zhu

    Citation: Radiation Oncology 2019 14:168

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  8. Content type: Research

    The purpose of this study was to assess the feasibility, efficacy and toxicity of fiducial marker implantation and tracking in CyberKnife® stereotactic radiation therapy (SBRT) applied to extracranial locations.

    Authors: Nathaniel Scher, Marc Bollet, Gauthier Bouilhol, Remi Tannouri, Imane Khemiri, Aurelie Vouillaume, Noura Sellami, Rie Von Eyben, Jean-Michel Vannetzel, Ilan Darmon, Luc Rotenberg, Hanah Lamallem, Olivier Bauduceau, Denis Foster and Alain Toledano

    Citation: Radiation Oncology 2019 14:167

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  9. Content type: Research

    Sarcopenia, the critical depletion of skeletal muscle mass, is an independent prognostic factor in several tumor entities for treatment-related toxicity and survival. In esophageal cancer, there have been conf...

    Authors: Cédric M. Panje, Laura Höng, Stefanie Hayoz, Vickie E. Baracos, Evelyn Herrmann, Helena Garcia Schüler, Urs R. Meier, Guido Henke, Sabina Schacher, Hanne Hawle, Marie-Aline Gérard, Thomas Ruhstaller and Ludwig Plasswilm

    Citation: Radiation Oncology 2019 14:166

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  10. Content type: Research

    To provide fast and accurate dose calculation in voxelized geometries for proton radiation therapy by implementing an adaptive step size algorithm in the proton macro Monte Carlo (pMMC) method.

    Authors: Reto Kueng, Daniel Frei, Werner Volken, Fabian Stuermlin, Marco F. M. Stampanoni, Daniel M. Aebersold, Peter Manser and Michael K. Fix

    Citation: Radiation Oncology 2019 14:165

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  11. Content type: Research

    In prostate cancer patients, imaging of bone metastases is enhanced through the use of sodium fluoride positron emission tomography (18F-NaF PET/CT). This imaging technique shows areas of enhanced osteoblastic ac...

    Authors: Nicholas Hardcastle, Michael S. Hofman, Ching-Yu Lee, Jason Callahan, Lisa Selbie, Farshad Foroudi, Mark Shaw, Sarat Chander, Andrew Lim, Brent Chesson, Declan G. Murphy, Tomas Kron and Shankar Siva

    Citation: Radiation Oncology 2019 14:164

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  12. Content type: Research

    To determine the feasibility of PET/CT-based image-guided moderate hypofractionated thoracic irradiation (Hypo-IGRT) in locally advanced node-positive non-small cell lung cancer patients with highly compromise...

    Authors: Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Nina-Sophie Schmidt-Hegemann, Lukas Käsmann, Cherylina Wijaya, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2019 14:163

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  13. Content type: Research

    The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials const...

    Authors: David Hoffman, Irena Dragojević, Jeremy Hoisak, David Hoopes and Ryan Manger

    Citation: Radiation Oncology 2019 14:162

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  14. Content type: Research

    The prognosis of N categories for patients with non-surgical esophageal carcinoma based on the number of metastatic lymph nodes is controversial. The present study analyzes prognostic implications of the numbe...

    Authors: Zongxing Zhao, Yanan Zhang, Peiliang Wang, Xin Wang and Minghuan Li

    Citation: Radiation Oncology 2019 14:161

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  15. Content type: Research

    Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection. In case of anaplastic meningiomas (WHO...

    Authors: Saman Moritz Hemmati, Pirus Ghadjar, Arne Grün, Harun Badakhshi, Sebastian Zschaeck, Carolin Senger, Güliz Acker, Martin Misch, Volker Budach and David Kaul

    Citation: Radiation Oncology 2019 14:160

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  16. Content type: Research

    This study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence (IBTR) based on our data on re-operative sentinel lymph node biopsy (re...

    Authors: Ayaka Sato, Takehiko Sakai, Takuji Iwase, Fumiko Kano, Kiyomi Kimura, Akiko Ogiya, Mitsuru Koizumi, Masahiko Tanabe, Rie Horii, Futoshi Akiyama, Takayuki Ueno and Shinji Ohno

    Citation: Radiation Oncology 2019 14:159

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  17. Content type: Research

    To report results from our phase I dose-escalation study of stereotactic body radiotherapy (SBRT) using 4 fractions for patients with localized prostate cancer.

    Authors: Takuro Kainuma, Shogo Kawakami, Hideyasu Tsumura, Takefumi Satoh, Ken-ichi Tabata, Masatsugu Iwamura, Kazushige Hayakawa and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:158

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  18. Content type: Research

    Radiotherapy is frequently used in the therapy of lymphoma. Since lymphoma, for example Hodgkin’s disease, frequently affect rather young patients, the induction of secondary cancer or other long-term adverse ...

    Authors: S. Lautenschlaeger, G. Iancu, V. Flatten, K. Baumann, M. Thiemer, C. Dumke, K. Zink, H. Hauswald, D. Vordermark, C. Mauz-Körholz, R. Engenhart-Cabillic and F. Eberle

    Citation: Radiation Oncology 2019 14:157

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  19. Content type: Research

    Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-...

    Authors: Daniel Karpf, Mazen Sakka, Martin Metzger and Gerhard G. Grabenbauer

    Citation: Radiation Oncology 2019 14:156

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  20. Content type: Research

    Transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are cytokines involved in fibrotic processes causing radiotherapy (RT)-induced cardiovascular changes. We aimed to investiga...

    Authors: Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: Radiation Oncology 2019 14:155

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  21. Content type: Research

    Target localization in radiation therapy is affected by numerous sources of uncertainty. Despite measures to minimize the breathing motion, the treatment of hypofractionated liver radiation therapy is further ...

    Authors: Gye Won Choi, Yelin Suh, Prajnan Das, Joseph Herman, Emma Holliday, Eugene Koay, Albert C. Koong, Sunil Krishnan, Bruce D. Minsky, Grace L. Smith, Cullen M. Taniguchi and Sam Beddar

    Citation: Radiation Oncology 2019 14:154

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  22. Content type: Research

    The heart and lungs are routinely exposed to incidental irradiation during adjuvant radiotherapy (RT) of breast cancer. We analyzed the impact of patient and treatment characteristics on heart and lung dose in...

    Authors: Tobias Finazzi, Van-Trinh Nguyen, Frank Zimmermann and Alexandros Papachristofilou

    Citation: Radiation Oncology 2019 14:153

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  23. Content type: Research

    Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has ne...

    Authors: Ning Han, Xintong Lyu, Guang Li and Qiao Qiao

    Citation: Radiation Oncology 2019 14:151

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  24. Content type: Research

    The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos i...

    Authors: Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang and Lei Gao

    Citation: Radiation Oncology 2019 14:149

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  25. Content type: Methodology

    To evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.

    Authors: Mohamed Zaid, Nimit Bajaj, Hannah Burrows, Ryan Mathew, Annie Dai, Christopher T. Wilke, Stephen Palasi, Ryan Hergenrother, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David I. Rosenthal…

    Citation: Radiation Oncology 2019 14:148

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  26. Content type: Research

    There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution exp...

    Authors: Angela Y. Jia, Amol Narang, Bashar Safar, Atif Zaheer, Adrian Murphy, Nilofer S. Azad, Susan Gearhart, Sandy Fang, Jonathan Efron, Tam Warczynski, Amy Hacker-Prietz and Jeffrey Meyer

    Citation: Radiation Oncology 2019 14:147

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  27. Content type: Review

    At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated wi...

    Authors: Jingxuan Fu, Weiping Wang, Yidan Wang, Chengeng Liu and Peichang Wang

    Citation: Radiation Oncology 2019 14:146

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  28. Content type: Research

    Heterogeneous target doses are a common by-product from attempts to improve normal tissue sparing in radiosurgery treatment planning. These regions of escalated dose within the target may increase tumor contro...

    Authors: William T. Hrinivich, Todd R. McNutt and Jeffrey J. Meyer

    Citation: Radiation Oncology 2019 14:145

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  29. Content type: Research

    Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...

    Authors: Sergiu Scobioala, Christopher Kittel, Khaled Elsayad, Kai Kroeger, Michael Oertel, Laith Samhouri, Uwe Haverkamp and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:143

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  30. Content type: Research

    Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...

    Authors: Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol and David Azria

    Citation: Radiation Oncology 2019 14:142

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  31. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber

    Citation: Radiation Oncology 2019 14:141

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  32. Content type: Research

    To investigate the prognostic significance of positron emission tomography (PET) parameters from F-18 fluorodeoxyglucose (FDG) PET scans performed pre- and post- chemo-radiotherapy (CRT) for squamous cell carc...

    Authors: Michael Peter Jones, George Hruby, Ur Metser, Swetha Sridharan, Anne Capp, Mahesh Kumar, Sarah Gallagher, Natalie Rutherford, Carl Holder, Christopher Oldmeadow and Jarad Martin

    Citation: Radiation Oncology 2019 14:140

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  33. Content type: Research

    This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system.

    Authors: Jung-in Kim, Jong Min Park, Chang Heon Choi, Hyun Joon An, Yi-Jun Kim and Jin Ho Kim

    Citation: Radiation Oncology 2019 14:139

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  34. Content type: Research

    The aim of this study was to explore the impact of including or excluding the ischiorectal fossa (IRF) within the clinical target volume during neoadjuvant chemoradiotherapy (NCRT) using intensity modulated ra...

    Authors: Maxiaowei Song, Jianhao Geng, Lin Wang, Yongheng Li, Xianggao Zhu, Xiaofan Li, Lan Mi, Aiwen Wu, Yifan Peng, Yunfeng Yao, Yangzi Zhang, Hongzhi Wang, Chen Shi, Yong Cai and Weihu Wang

    Citation: Radiation Oncology 2019 14:138

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  35. Content type: Research

    To quantify the dosimetric parameters of different bone marrow sparing strategies and to determine the optimal strategy for cervical cancer patients undergoing postoperative intensity-modulated radiotherapy (I...

    Authors: Zhirong Bao, Dajiang Wang, Shupeng Chen, Min Chen, Dazhen Jiang, Chunxu Yang, Hui Liu, Jing Dai and Conghua Xie

    Citation: Radiation Oncology 2019 14:118

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  36. Content type: Research

    We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma.

    Authors: Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Takuya Kaminuma, Masaya Miyazaki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno and Takashi Nakano

    Citation: Radiation Oncology 2019 14:137

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  37. Content type: Research

    Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for the treatment of prostate cancer. However, few have reported outcomes for pros...

    Authors: Mark E. Hwang, Mark Mayeda, Maria Liz, Brenda Goode-Marshall, Lissette Gonzalez, Carl D. Elliston, Catherine S. Spina, Oscar A. Padilla, Sven Wenske and Israel Deutsch

    Citation: Radiation Oncology 2019 14:136

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  38. Content type: Research

    Along with breast-conserving surgery (BCS), adjuvant radiotherapy (RT) of patients with early breast cancer plays a crucial role in the oncologic treatment concept. Conventionally, irradiation is carried out w...

    Authors: Michael Mayinger, Kai Joachim Borm, Constantin Dreher, Hendrik Dapper, Marciana-Nona Duma, Markus Oechsner, Severin Kampfer, Stephanie Elisabeth Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:135

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  39. Content type: Review

    Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby

    Citation: Radiation Oncology 2019 14:134

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  40. Content type: Research

    The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita

    Citation: Radiation Oncology 2019 14:133

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  41. Content type: Research

    Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Authors: Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Felix Behling, Marco Skardelly, Benjamin Bender, Daniel Zips and Franziska Eckert

    Citation: Radiation Oncology 2019 14:132

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  42. Content type: Research

    To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee

    Citation: Radiation Oncology 2019 14:131

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  43. Content type: Research

    To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang

    Citation: Radiation Oncology 2019 14:129

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  44. Content type: Research

    Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

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  45. Content type: Case report

    The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

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