Articles

BRAF mutation correlates with worse local–regional control following radiation therapy in patients with stage III melanoma

In patients with stage III melanoma, the use of adjuvant radiation therapy (RT) after lymph node dissection (LND) may be currently considered in selected high-risk patients to improve tumor control. Melanomas ...

Authors: Adam R. Wolfe, Priyanka Chablani, Michael R. Siedow, Eric D. Miller, Steve Walston, Kari L. Kendra, Evan Wuthrick and Terence M. Williams

Treatment outcome and compliance to dose-intensified linac-based SBRT for unfavorable prostate tumors using a novel real-time organ-motion tracking

To report preliminary data on treatment outcome and compliance to dose-intensified organ sparing SBRT for prostate cancer using a novel electromagnetic transmitter-based tracking system (RayPilotÒ System) to a...

Authors: Raffaella Lucchini, Denis Panizza, Riccardo Ray Colciago, Veronica Vernier, Martina Camilla Daniotti, Valeria Faccenda and Stefano Arcangeli

Online MR evaluation of inter- and intra-fraction uterus motions and bladder volume changes during cervical cancer external beam radiotherapy

The purpose of the study was to assess the uterus motions and bladder volume changes of fractional movements in cervical sites throughout the external beam radiotherapy (EBRT) treatment.

Authors: Xu Li, Lizhen Wang, Zhen Cui, Yukun Li, Pei Liu, Yungang Wang, Jinhong Zhu, Jianmin Zhu, Yong Yin and Zhenjiang Li

Palliative radiotherapy for painful lymph node metastases

There is limited evidence concerning radiotherapy for painful lymph node metastases (PLM). We evaluated the effectiveness of radiotherapy for PLM using the International Consensus Endpoint in a subgroup analys...

Authors: Kohsei Yamaguchi, Tetsuo Saito, Ryo Toya, Etsushi Tomitaka, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takahiro Watakabe, Hirohito Otsuka and Natsuo Oya

Sintilimab, stereotactic body radiotherapy and granulocyte–macrophage colony stimulating factor as second-line therapy for advanced non-small cell lung cancer: safety run-in results of a multicenter, single-arm, phase II trial

The SWORD trial is the first multicenter, single arm, phase II study assessing the safety and efficacy of a PD-1 inhibitor (Sintilimab), stereotactic body radiotherapy (SBRT) and granulocyte–macrophage colony ...

Authors: Jianjiao Ni, Yue Zhou, Lin Wu, Xinghao Ai, Xiaorong Dong, Qian Chu, Chengbo Han, Xiaofei Wang and Zhengfei Zhu

Patterns of nodal spread in stage III NSCLC: importance of EBUS-TBNA and ¹⁸F-FDG PET/CT for radiotherapy target volume definition

The aim of this study was to compare the pattern of intra-patient spread of lymph-node (LN)-metastases within the mediastinum as assessed by ¹⁸F-FDG PET/CT and systematic endobronchial ultrasound-guided transbron...

Authors: Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Christoph Pöttgen, Nika Guberina, Thomas Gauler, Till Ploenes, Lale Umutlu, Dirk Theegarten, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Metzenmacher, Marcel Wiesweg, Rüdiger Karpf-Wissel, Martin Schuler, Ken Herrmann…

Evaluation of auto-segmentation accuracy of cloud-based artificial intelligence and atlas-based models

Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been a critical issue in this process. An atlas-based automatic segmentation w...

Authors: Yuka Urago, Hiroyuki Okamoto, Tomoya Kaneda, Naoya Murakami, Tairo Kashihara, Mihiro Takemori, Hiroki Nakayama, Kotaro Iijima, Takahito Chiba, Junichi Kuwahara, Shouichi Katsuta, Satoshi Nakamura, Weishan Chang, Hidetoshi Saitoh and Hiroshi Igaki

Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma

Proton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general, includes placing radiopaque clips to ensure exact eye-positioning during r...

Authors: Johannes Gollrad, Christopher Rabsahl, Aline-Isabel Riechardt, Jens Heufelder, Andrea Stroux, Ute Goerling, Antonia Joussen, Volker Budach and Dirk Boehmer

Effect of abdominal compression on target movement and extension of the external boundary of peripheral lung tumours treated with stereotactic radiotherapy based on four-dimensional computed tomography

This study aimed to investigate the effect of abdominal compression on tumour motion and target volume and to determine suitable planning target volume (PTV) margins for patients treated with lung stereotactic...

Authors: Yuanjun Qi, Jianbin Li, Yingjie Zhang, Qian Shao, Xijun Liu, Fengxiang Li, Jinzhi Wang, Zhenxiang Li and Wei Wang

Radiotherapy dose–volume parameters predict facial lymphedema after concurrent chemoradiation for nasopharyngeal carcinoma

To investigate risk factors for developing radiation-associated facial lymphedema (FL) in nasopharyngeal carcinoma (NPC) patients after concurrent chemoradiation (CCRT).

Authors: Donghyun Kim, Jiho Nam, Wontaek Kim, Dahl Park, Jihyeon Joo, Hosang Jeon and Yongkan Ki

A dosimetric and radiobiological evaluation of VMAT following mastectomy for patients with left-sided breast cancer

To compare the dosimetric, normal tissue complication probability (NTCP), secondary cancer complication probabilities (SCCP), and excess absolute risk (EAR) differences of volumetric modulated arc therapy (VMA...

Authors: Yun Zhang, Yuling Huang, Shenggou Ding, Xingxing Yuan, Yuxian Shu, Jinhui Liang, Qingfeng Mao, Chunling Jiang and Jingao Li

Stereotactic body radiotherapy for osseous low alpha–beta resistant metastases for pain relief—SOLAR-P

Stereotactic Body Radiotherapy (SBRT) has shown effectiveness in treating bone metastases to alleviate pain. The benefit of SBRT may be further harnessed especially when radiating disease from primary malignan...

Authors: Eric K. Nguyen, Kimmen Quan, Sameer Parpia, Stephan Tran and Anand Swaminath

Combined effect of dose gradient and rotational error on prescribed dose coverage for single isocenter multiple brain metastases in frameless stereotactic radiotherapy

To evaluate the combined effect of rotational error and dose gradient on target dose coverage in frameless stereotactic radiotherapy.

Authors: Jai-Woong Yoon, Soah Park, Kwang-Ho Cheong, Sei-Kwon Kang and Tae Jin Han

Evaluation of inter- and intra-fraction 6D motion for stereotactic body radiation therapy of spinal metastases: influence of treatment time

The objective of this study was to analyze the amplitude of translational and rotational movements occurring during stereotactic body radiotherapy (SBRT) of spinal metastases in two different positioning devic...

Authors: Ahmed Hadj Henni, David Gensanne, Maximilien Roge, Chantal Hanzen, Guillaume Bulot, Elyse Colard and Sebastien Thureau

Influence of target dose heterogeneity on dose sparing of normal tissue in peripheral lung tumor stereotactic body radiation therapy

To evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).

Authors: Zhigong Wei, Xingchen Peng, Yan Wang, Lianlian Yang, Ling He, Zheran Liu, Jingjing Wang, Xiaoli Mu, Ruidan Li and Jianghong Xiao

Neuro-ophthalmologic outcomes of standard versus hypo-fractionated stereotactic radiotherapy of AVPM

Most anterior visual pathway meningiomas (AVPM) are benign and slow-growing, but these tumors may affect visual functions, including visual acuity (VA) and visual field (VF). Due to location, most are treated ...

Authors: Leor Zach, Amir Agami, Orit Furman, Moshe Attia, Zvi Cohen, Iris Ben-Bassat Mizrachi, Guy Tam, Zion Zibly, Ouzi Nissim, Roberto Spiegelmann and Ruth Huna-Baron

Multifocal high-grade glioma radiotherapy safety and efficacy

Multifocal manifestation of high-grade glioma is a rare disease with very unfavourable prognosis. The pathogenesis of multifocal glioma and pathophysiological differences to unifocal glioma are not fully under...

Authors: Daniel Felix Fleischmann, Rudolph Schön, Stefanie Corradini, Raphael Bodensohn, Indrawati Hadi, Jan Hofmaier, Robert Forbrig, Niklas Thon, Mario Dorostkar, Claus Belka and Maximilian Niyazi

Outcome of intracerebral cavernoma treated by Gamma Knife radiosurgery based on a double-blind assessment of treatment indication

The benefit and the risk profile of Gamma Knife radiosurgery (GKRS) for intracerebral cavernoma remains incompletely defined in part due to the natural history of low incidence of bleeding and spontaneous regr...

Authors: Chiung-Chyi Shen, Ming Hsi Sun, Meng-Yin Yang, Weir-Chiang You, Meei-Ling Sheu, Yen-Ju Chen, Ying Ju Chen, Jason Sheehan and Hung-Chuan Pan

Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT)

Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel...

Authors: Catherine R. Hanna, Sean M. O’Cathail, Janet S. Graham, Mark Saunders, Leslie Samuel, Mark Harrison, Lynsey Devlin, Joanne Edwards, Daniel R. Gaya, Caroline A. Kelly, Liz-Anne Lewsley, Noori Maka, Paula Morrison, Louise Dinnett, Susan Dillon, Jacqueline Gourlay…

Correction to: Adjuvant hysterectomy following primary chemoradiation for stage IB2 and IIA2 cervical cancer: a retrospective comparison of complications for open versus minimally invasive surgery

Authors: Heather Miller, Koji Matsuo, Lynda D. Roman, Annie A. Yessaian, Huyen Q. Pham, Marianne Hom, Antonio Castaneda, Anthony Pham, Omar Ragab, Laila Muderspach, Marcia Ciccone and Laurie L. Brunette

Efficacy of radiotherapy for gastric bleeding associated with advanced gastric cancer

Gastric bleeding negatively impacts the quality of life of patients with unresectable advanced gastric cancer and is frequently lethal. We investigated the efficacy of RT for palliation of gastric bleeding fro...

Authors: Joongyo Lee, Hwa Kyung Byun, Woong Sub Koom, Yong Chan Lee and Jinsil Seong

Effect of osteoporotic conditions on the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningioma

Disruption of the tumor-brain barrier in meningioma is a crucial factor in peritumoral brain edema (PTBE). We previously reported the possible effect of osteoporosis on the integrity of the arachnoid trabecula...

Authors: Sang Mook Kang, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Young Soo Kim and Myung-Hoon Han

Development of a model for fibroblast-led collective migration from breast cancer cell spheroids to study radiation effects on invasiveness

Invasiveness is a major factor contributing to metastasis of tumour cells. Given the broad variety and plasticity of invasion mechanisms, assessing potential metastasis-promoting effects of irradiation for spe...

Authors: Jia Mei, Claudia Böhland, Anika Geiger, Iris Baur, Kristina Berner, Steffen Heuer, Xue Liu, Laura Mataite, M. Camila Melo-Narváez, Erdem Özkaya, Anna Rupp, Christian Siebenwirth, Felix Thoma, Matthias F. Kling and Anna A. Friedl

Dosimetric comparison and biological evaluation of fixed-jaw intensity-modulated radiation therapy for T-shaped esophageal cancer

To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

Authors: Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu, Yanhua Duan, Aihui Feng and Zhiyong Xu

High-dose radiotherapy in newly diagnosed low-grade gliomas with nonmethylated O(6)-methylguanine-DNA methyltransferase

Patients with low-grade gliomas (LGGs) harboring O⁶-methylguanine-DNA methyltransferase promoter nonmethylation (MGMT-non-pM) have a particularly short survival and are great resistance to chemotherapy. The objec...

Authors: Yanwei Liu, Yanong Li, Peng Wang, Li Chen, Jin Feng and Xiaoguang Qiu

Correction to: High dose simultaneous integrated boost for node positive cervical cancer

Authors: Iresha Jayatilakebanda, Yat Man Tsang and Peter Hoskin

Treatment outcomes of passive scattering proton beam therapy for stage I non-small cell lung cancer

To investigate the treatment outcomes of passive scattering proton beam therapy using stereotactic ablative radiotherapy (SABR) or hypofractionated radiation therapy (RT) for inoperable patients or those who r...

Authors: Unurjargal Bayasgalan, Sung Ho Moon, Jong Hwi Jeong, Tae Hyun Kim, Kwan Ho Cho and Yang-Gun Suh

Deep learning method for prediction of patient-specific dose distribution in breast cancer

Patient-specific dose prediction improves the efficiency and quality of radiation treatment planning and reduces the time required to find the optimal plan. In this study, a patient-specific dose prediction mo...

Authors: Sang Hee Ahn, EunSook Kim, Chankyu Kim, Wonjoong Cheon, Myeongsoo Kim, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Dae Yong Kim and Jong Hwi Jeong

Short-course compared to long-course palliative radiotherapy for oesophageal cancer: a single centre observational cohort study

Common symptoms of oesophageal cancer are dysphagia, pain, and bleeding. These symptoms can be relieved with palliative radiotherapy. The aim of this study was to analyse the outcome of two different palliativ...

Authors: Halla Sif Ólafsdóttir, Fredrik Klevebro, Nelson Ndegwa and Gabriella Alexandersson von Döbeln

Sarcopenia and dosimetric parameters in relation to treatment-related leukopenia and survival in anal cancer

Treatment-related white blood cell (WBC) toxicity has been associated with an inferior prognosis in different malignancies, including anal cancer. The aim of the present study was to investigate predictors of ...

Authors: Martin P. Nilsson, Anders Johnsson and Jonas Scherman

⁶⁸Ga-DOTATATE PET-CT as a tool for radiation planning and evaluating treatment responses in the clinical management of meningiomas

Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as ⁶⁸ Ga-DOTATATE have been recently shown to aid in the imaging and identification of me...

Authors: Emily S. Kowalski, Rahul Khairnar, Anton A. Gryaznov, Vivek Kesari, Antony Koroulakis, Prashant Raghavan, Wengen Chen, Graeme Woodworth and Mark Mishra

Investigation of the clinical inter-observer bias in prostate fiducial marker image registration between CT and MR images

Inter-modality image registration between computed tomography (CT) and magnetic resonance (MR) images is associated with systematic uncertainties and the magnitude of these uncertainties is not well documented...

Authors: Emilia Persson, Sevgi Emin, Jonas Scherman, Christian Jamtheim Gustafsson, Patrik Brynolfsson, Sofie Ceberg, Adalsteinn Gunnlaugsson and Lars E. Olsson

Comparison of stereotactic body radiation therapy versus fractionated radiation therapy for primary liver cancer with portal vein tumor thrombus

To compare the clinical outcomes of stereotactic body radiation therapy (SBRT) and fractionated radiation therapy (FRT) for primary liver cancer with portal vein tumor thrombus (PVTT).

Authors: Sujing Zhang, Li He, Changwen Bo, Shufang Yang, Yonghui An, Na Li, Yingchun Zhao, Liping Zhao, Wenhua Ma and Zheng Zheng

Stereotactic ablative body radiotherapy boost for cervical cancer when brachytherapy boost is not feasible

The purpose of this study was to analyze the treatment efficacy and safety of stereotactic ablative body radiotherapy (SABR) boost for cervical cancer patients not amenable to brachytherapy.

Authors: Tae Hoon Lee, Changhoon Song, In Ah Kim, Jae-Sung Kim, Yong Beom Kim, Kidong Kim, Jae Hong No, Dong Hoon Suh, Jin-Beom Chung and Keun-Yong Eom

End of treatment cone-beam computed tomography (CBCT) is predictive of radiation response and overall survival in oropharyngeal squamous cell carcinoma

Image guidance in radiation oncology has resulted in significant improvements in the accuracy and precision of radiation therapy (RT). Recently, the resolution and quality of cone beam computed tomography (CBC...

Authors: Whitney Sumner, Sangwoo S. Kim, Lucas Vitzthum, Kevin Moore, Todd Atwood, James Murphy, Sayuri Miyauchi, Joseph A. Califano, Loren K. Mell, Arno J. Mundt and Andrew B. Sharabi

Applications of various range shifters for proton pencil beam scanning radiotherapy

A range pull-back device, such as a machine-related range shifter (MRS) or a universal patient-related range shifter (UPRS), is needed in pencil beam scanning technique to treat shallow tumors.

Authors: Haibo Lin, Chengyu Shi, Sheng Huang, Jiajian Shen, Minglei Kang, Qing Chen, Huifang Zhai, James McDonough, Zelig Tochner, Curtiland Deville, Charles B. Simone II and Stefan Both

Dosimetric benefits of daily treatment plan adaptation for prostate cancer stereotactic body radiotherapy

Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different ada...

Authors: Miriam Eckl, Gustavo R. Sarria, Sandra Springer, Marvin Willam, Arne M. Ruder, Volker Steil, Michael Ehmann, Frederik Wenz and Jens Fleckenstein

Intra-fractional dosimetric analysis of image-guided intracavitary brachytherapy of cervical cancer

To assess the intra-fractional dosimetric variations of image-guided brachytherapy of cervical cancer.

Authors: Junfang Yan, Jiawei Zhu, Kai Chen, Lang Yu and Fuquan Zhang

Does the protocol-required uniform margin around the CTV adequately account for setup inaccuracies in whole breast irradiation?

To use cone-beam computed tomography (CBCT) imaging to determine the impacts of patient characteristics on the magnitude of geometric setup errors and obtain patient-specific planning target volume (PTV) margi...

Authors: Jurui Luo, Zhihai Yin, Zhen Zhang, Xiaomao Guo, Xiaoli Yu and Juanqi Wang

Personalising treatment plan quality review with knowledge-based planning in the TROG 15.03 trial for stereotactic ablative body radiotherapy in primary kidney cancer

Quality assurance (QA) of treatment plans in clinical trials improves protocol compliance and patient outcomes. Retrospective use of knowledge-based-planning (KBP) in clinical trials has demonstrated improved ...

Authors: Nicholas Hardcastle, Olivia Cook, Xenia Ray, Alisha Moore, Kevin L. Moore, David Pryor, Alana Rossi, Farshad Foroudi, Tomas Kron and Shankar Siva

Comparison of the composition of lymphocyte subpopulations in non-relapse and relapse patients with squamous cell carcinoma of the head and neck before, during radiochemotherapy and in the follow-up period: a multicenter prospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)

Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of majo...

Authors: Minli Niu, Stephanie E. Combs, Annett Linge, Mechthild Krause, Michael Baumann, Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu and Gabriele Multhoff

Interfractional target changes in brain metastases during 13-fraction stereotactic radiotherapy

The risk for radiation necrosis is lower in fractionated stereotactic radiotherapy (SRT) than in conventional radiotherapy, and 13-fraction SRT is our method of choice for the treatment of brain metastases ≥ a...

Authors: Megumi Uto, Kengo Ogura, Tomohiro Katagiri, Keiichi Takehana and Takashi Mizowaki

Implementation and experimental evaluation of Mega-voltage fan-beam CT using a linear accelerator

Mega-voltage fan-beam Computed Tomography (MV-FBCT) holds potential in accurate determination of relative electron density (RED) and proton stopping power ratio (SPR) but is not widely available.

Authors: Hao Gong, Shengzhen Tao, Justin D. Gagneur, Wei Liu, Jiajian Shen, Cynthia H. McCollough, Yanle Hu and Shuai Leng

Clinical outcomes and patterns of failure of head and neck mucosal melanoma treated with multiple treatment modalities

The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide ...

Authors: Qing-Qing Xu, Yan-Zhen Lai, Zi-Lu Huang, Zi-Yi Zeng, Ya-Ni Zhang, Rui-Yao Ou, Wen-Min Wu, Lei Chen and Li-Xia Lu

Functional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145

Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuxim...

Authors: Raik Schneider, Günther Gademann, Hans-Joachim Ochel, Karsten Neumann, Burkhard Jandrig, Peter Hass, Mathias Walke, Martin Schostak, Thomas Brunner and Frank Christoph

Feasibility of Conebeam CT-based online adaptive radiotherapy for neoadjuvant treatment of rectal cancer

Online adaptive radiotherapy has the potential to reduce toxicity for patients treated for rectal cancer because smaller planning target volumes (PTV) margins around the entire clinical target volume (CTV) are...

Authors: Rianne de Jong, Jorrit Visser, Niek van Wieringen, Jan Wiersma, Debby Geijsen and Arjan Bel

Development of in-house fully residual deep convolutional neural network-based segmentation software for the male pelvic CT

This study aimed to (1) develop a fully residual deep convolutional neural network (CNN)-based segmentation software for computed tomography image segmentation of the male pelvic region and (2) demonstrate its...

Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Pascal Baillehache, Yusuke Fujimoto, Shota Nakagawa, Yusuke Saruya, Tatsumasa Kabasawa and Takashi Mizowaki

Correlation between the γ passing rates of IMRT plans and the volumes of air cavities and bony structures in head and neck cancer

Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the corr...

Authors: Zhengwen Shen, Xia Tan, Shi Li, Xiumei Tian, Huanli Luo, Ying Wang and Fu Jin

Dosimetric comparison of MR-linac-based IMRT and conventional VMAT treatment plans for prostate cancer

The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac)...

Authors: Vanessa Da Silva Mendes, Lukas Nierer, Minglun Li, Stefanie Corradini, Michael Reiner, Florian Kamp, Maximilian Niyazi, Christopher Kurz, Guillaume Landry and Claus Belka

Diffusion-weighted MRI and ¹⁸F-FDG PET/CT in assessing the response to neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma

Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in ...

Authors: Xin Xu, Zhi-Yong Sun, Hua-Wei Wu, Chen-Peng Zhang, Bin Hu, Ling Rong, Hai-Yan Chen, Hua-Ying Xie, Yu-Ming Wang, Hai-Ping Lin, Yong-Rui Bai, Qing Ye and Xiu-Mei Ma