Articles

Efficacy and toxicity of re-irradiation for esophageal cancer patients with locoregional recurrence: a retrospective analysis

There is no standard treatment for locoregional recurrent (LR) esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy (RT) previously. This retrospective study aimed to examine the effica...

Authors: Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng and Jinming Yu

Prostate cancer tumour control probability modelling for external beam radiotherapy based on multi-parametric MRI-GTV definition

To evaluate the applicability and estimate the radiobiological parameters of linear-quadratic Poisson tumour control probability (TCP) model for primary prostate cancer patients for two relevant target structu...

Authors: Ilias Sachpazidis, Panayiotis Mavroidis, Constantinos Zamboglou, Christina Marie Klein, Anca-Ligia Grosu and Dimos Baltas

Evaluation of OAR dose sparing and plan robustness of beam-specific PTV in lung cancer IMRT treatment

Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Here, we proposed a margin concept that takes into co...

Authors: Yu Chang, Feng Xiao, Hong Quan and Zhiyong Yang

A non-invasive ultrasound imaging method to measure acute radiation-induced bladder wall thickening in rats

Methods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim se...

Authors: Antonello E. Spinelli, Andrea Bresolin, Stefania Zuppone, Laura Perani, Giuseppe Fallara, Nadia Di Muzio, Riccardo Vago, Claudio Fiorino and Cesare Cozzarini

Strict bladder filling and rectal emptying during prostate SBRT: Does it make a dosimetric or clinical difference?

To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences.

Authors: David J. Byun, Daniel J. Gorovets, Lauren M. Jacobs, Laura Happersett, Pengpeng Zhang, Xin Pei, Sarah Burleson, Zhigang Zhang, Margie Hunt, Sean McBride, Marisa A. Kollmeier and Michael J. Zelefsky

¹²⁵I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts

Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s...

Authors: Qing Jin, Cunzhi Lin, Xinhong Zhu, Yiwei Cao, Caihong Guo and Lijun Wang

The prognostic value of the lymph node ratio for local advanced gastric cancer patients with intensity-modulated radiation therapy and concurrent chemotherapy after radical gastrectomy in China

Nearly 50% of new gastric cancer cases and gastric cancer-related deaths worldwide occur in China. No global consensus has been reached about the optimal management of locally advanced gastric cancer. Although...

Authors: Yongqiang Yang, Yifu Ma, Xiaoyong Xiang, Pengfei Xing, Yongyou Wu, Liyuan Zhang and Ye Tian

Leaf open time sinogram (LOTS): a novel approach for patient specific quality assurance of total marrow irradiation

There is no ideal detector-phantom combination to perform patient specific quality assurance (PSQA) for Total Marrow (TMI) and Lymphoid (TMLI) Irradiation plan. In this study, 3D dose reconstruction using mega...

Authors: Rajesh Thiyagarajan, Dayananda Shamurailatpam Sharma, Suryakant Kaushik, Mayur Sawant, K. Ganapathy, N. Arunai Nambi Raj, Srinivas Chilukuri, Sham C. Sundar, Kartikeswar Ch. Patro, Arjunan Manikandan, M. P. Noufal, Rangasamy Sivaraman, Jose Easow and Rakesh Jalali

Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer

Intensity-modulated radiotherapy (IMRT) improves dose homogeneity and late toxicity compared to simple tangential techniques in adjuvant whole-breast radiotherapy for patients with breast cancer. Simultaneous-...

Authors: David Krug, Christine Köder, Matthias F. Häfner, Nathalie Arians, Semi B. Harrabi, Stefan A. Koerber, Tobias Forster, Ingmar Schlampp, Christof Sohn, Joerg Heil, Holger Hof, Juliane Hörner-Rieber and Jürgen Debus

Phase I/IIa trial of androgen deprivation therapy, external beam radiotherapy, and stereotactic body radiotherapy boost for high-risk prostate cancer (ADEBAR)

To evaluate the clinical outcomes of combination of androgen deprivation therapy (ADT), whole pelvic radiotherapy (WPRT), and stereotactic body radiotherapy (SBRT) boost in high-risk prostate cancer patients.

Authors: Yeon Joo Kim, Hanjong Ahn, Choung-Soo Kim and Young Seok Kim

Efficacy and safety-in analysis of short-course radiation followed by mFOLFOX-6 plus avelumab for locally advanced rectal adenocarcinoma

Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...

Authors: Ali Shamseddine, Youssef H. Zeidan, Ziad El Husseini, Malek Kreidieh, Monita Al Darazi, Rim Turfa, Joseph Kattan, Ibrahim Khalifeh, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al Awabdeh, Samer Deeba, Faek Jamali, Issa Mohamad…

Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy

This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to...

Authors: Sheng Chang, Gang Liu, Lewei Zhao, Joshua T. Dilworth, Weili Zheng, Saada Jawad, Di Yan, Peter Chen, Craig Stevens, Peyman Kabolizadeh, Xiaoqiang Li and Xuanfeng Ding

Long-term outcomes of moderately hypofractionated radiotherapy (67.5 Gy in 25 fractions) for prostate cancer confined to the pelvis: a single center retrospective analysis

There is an increasing application of moderately hypofractionated radiotherapy for prostate cancer. We presented our outcomes and treatment-related toxicities with moderately hypofractionated (67.5 Gy in 25 fr...

Authors: Lihong Yao, Jianzhong Shou, Shulian Wang, Yongwen Song, Hui Fang, Ningning Lu, Yuan Tang, Bo Chen, Shunan Qi, Yong Yang, Hao Jing, Jing Jin, Zihao Yu, Yexiong Li and Yueping Liu

Effectiveness and cost-effectiveness analysis of nimotuzumab for the radiotherapy of locoregionally advanced nasopharyngeal carcinoma

This study aimed to assess the effectiveness and cost-effectiveness of nimotuzumab in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Authors: Zhaodong Fei, Ting Xu, Mengying Li, Taojun Chen, Li Li, Xiufang Qiu and Chuanben Chen

OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized open label trial

Conservative surgery followed by breast and nodal irradiation is the standard loco-regional early breast cancer (BC) treatment for patients with four or more involved lymph nodes. However, the treatment strate...

Authors: Manuel Algara López, Elvira Rodríguez García, Inmaculada Beato Tortajada, Francisco José Martínez Arcelus, Juan Salinas Ramos, José Reyes Rodríguez garrido, Xavier Sanz Latiesas, Ana Soler Rodríguez, Germán Juan Rijo and Amanda Flaquer García

Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy

Proton pencil beam scanning (PBS) represents an interesting option for the treatment of breast cancer (BC) patients with nodal involvement. Here we compare tangential 3D-CRT and VMAT to PBS proton therapy (PT)...

Authors: Giorgio Cartechini, Francesco Fracchiolla, Loris Menegotti, Emanuele Scifoni, Chiara La Tessa, Marco Schwarz, Paolo Farace and Francesco Tommasino

Can ⁶⁸Ga-prostate specific membrane antigen positron emission tomography/computerized tomography provide an accurate lymph node staging for patients with medium/high risk prostate cancer? A diagnostic meta-analysis

This article aims to evaluate the diagnostic value of ⁶⁸Gallium-PSMA positron emission tomography/computerized tomography (⁶⁸Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a...

Authors: Lei Peng, Jinze Li, Chunyang Meng, Jinming Li, Chengyu You, Dandan Tang, Tangqiang Wei, Wei Xiong and Yunxiang Li

COVID-19 and radiation oncology: the experience of a two-phase plan within a single institution in central Italy

COVID-19 in Italy has led to the need to reorganize hospital protocols with a significant risk of interruption to cancer treatment programs. In this report, we will focus on a management model covering the two...

Authors: Luciana Caravatta, Consuelo Rosa, Maria Bernadette Di Sciascio, Andrea Tavella Scaringi, Angelo Di Pilla, Lucia Anna Ursini, Maria Taraborrelli, Annamaria Vinciguerra, Antonietta Augurio, Monica Di Tommaso, Marianna Trignani, Marianna Nuzzo, Maria Daniela Falco, Andrea De Nicola, Nico Adorante, Fabiola Patani…

Efficacy and safety of CyberKnife radiosurgery in elderly patients with brain metastases: a retrospective clinical evaluation

Stereotactic radiosurgery (SRS) has been increasingly applied for up to 10 brain metastases instead of whole brain radiation therapy (WBRT) to achieve local tumor control while reducing neurotoxicity. Furtherm...

Authors: Gueliz Acker, Seyed-Morteza Hashemi, Josch Fuellhase, Anne Kluge, Alfredo Conti, Markus Kufeld, Anita Kreimeier, Franziska Loebel, Melina Kord, Diana Sladek, Carmen Stromberger, Volker Budach, Peter Vajkoczy and Carolin Senger

Image quality of 4D in-treatment CBCT acquired during lung SBRT using FFF beam: a phantom study

Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to ac...

Authors: Jihun Kim, Ki Chang Keum, Ho Lee, Chae-Seon Hong, Kwangwoo Park and Jin Sung Kim

A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response

In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers. ...

Authors: Jie Zhang, Anting Xu, Tingting Niu, Chengcheng Liu, Yongju Zhang, Tao Li, Jihua Wang, Yongjing Wang and Dianshui Sun

p63⁺Krt5⁺ basal cells are increased in the squamous metaplastic epithelium of patients with radiation-induced chronic Rhinosinusitis

Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the ...

Authors: Hongming Huang, Kai Sen Tan, Suizi Zhou, Tian Yuan, Jing Liu, Hsiao Hui Ong, Qianmin Chen, Junxiao Gao, Minghong Xu, Zhenchao Zhu, Qianhui Qiu and De Yun Wang

Cardiac radiation dose predicts survival in esophageal squamous cell carcinoma treated by definitive concurrent chemotherapy and intensity modulated radiotherapy

The prognostic significance of cardiac radiation dose in esophageal cancer after definitive concurrent chemoradiotherapy (CCRT) remains largely unknown. We aimed to investigate the association between cardiac ...

Authors: Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Jeffrey Shu-Ming Chang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung and Forn-Chia Lin

Efficacy of orbital radiotherapy in moderate-to-severe active graves’ orbitopathy including long-lasting disease: a retrospective analysis

We aimed to explore the efficacy of orbital radiotherapy (RT) in patients with moderate-to-severe active Graves’ orbitopathy (GO), including long-lasting disease, and to determine the predictive factors associ...

Authors: Jin Hwa Choi and Jeong Kyu Lee

Long-term analysis of multimodality treatment outcomes and prognosis of esthesioneuroblastomas: a single center results of 138 patients

The aim of this study is to evaluate the efficacy of different treatment strategies and the potential prognostic factors of esthesioneuroblastoma (ENB).

Authors: Meng Sun, Kai Wang, Yuan Qu, Jianghu Zhang, Shiping Zhang, Xuesong Chen, Jingbo Wang, Runye Wu, Ye Zhang, Junlin Yi, Jianping Xiao, Guozhen Xu, Xiaodong Huang and Jingwei Luo

Intensity-modulated radiation therapy versus three-dimensional conformal radiotherapy in head and neck squamous cell carcinoma: long-term and mature outcomes of a prospective randomized trial

To compare long-term disease-related outcomes and late radiation morbidity between intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in head and neck squamous c...

Authors: Tejpal Gupta, Shwetabh Sinha, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Naveen Mummudi, Monali Swain, Reena Phurailatpam, Kumar Prabhash and Jai Prakash Agarwal

Stereotactic body radiotherapy versus conventional/moderate fractionated radiation therapy with androgen deprivation therapy for unfavorable risk prostate cancer

Ultrahypofractionation using stereotactic body radiotherapy (SBRT) is an increasingly utilized technique for men with prostate cancer (PC). The comparative efficacy of SBRT plus androgen deprivation therapy (A...

Authors: Sagar A. Patel, Jeffrey M. Switchenko, Ben Fischer-Valuck, Chao Zhang, Brent S. Rose, Ronald C. Chen, Ashesh B. Jani and Trevor J. Royce

Application of dose-volume histogram prediction in biologically related models for nasopharyngeal carcinomas treatment planning

In this study, we employed a gated recurrent unit (GRU)-based recurrent neural network (RNN) using dosimetric information induced by individual beam to predict the dose-volume histogram (DVH) and investigated ...

Authors: Wufei Cao, Yongdong Zhuang, Lixin Chen and Xiaowei Liu

Radiotherapy in oncological emergencies: fast-track treatment planning

To report on our clinical experience with a newly implemented workflow for radiotherapy (RT) emergency treatments, which allows for a fast treatment application outside the regular working-hours, and its clini...

Authors: Lukas Nierer, Franziska Walter, Maximilian Niyazi, Roel Shpani, Guillaume Landry, Sebastian Marschner, Rieke von Bestenbostel, Dominika Dinkel, Gabriela Essenbach, Michael Reiner, Claus Belka and Stefanie Corradini

Radiation-induced lung toxicity – cellular and molecular mechanisms of pathogenesis, management, and literature review

Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-mo...

Authors: Lukas Käsmann, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Jürgen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber and Claus Belka

Reply to Ghaffari et al. “In regard to Cuccia et al.: impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy.”

Authors: Francesco Cuccia and Filippo Alongi

Locoregional recurrence patterns in women with breast cancer who have not undergone post-mastectomy radiotherapy

To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy.

Authors: Xuran Zhao, Yu Tang, Shulian Wang, Yong Yang, Hui Fang, Jianyang Wang, Hao Jing, Jianghu Zhang, Guangyi Sun, Siye Chen, Jing Jin, Yongwen Song, Yueping Liu, Bo Chen, Shunan Qi, Ning Li…

Evaluation of small bowel motion and feasibility of using the peritoneal space to replace bowel loops for dose constraints during intensity-modulated radiotherapy for rectal cancer

The goal of this study was to assess small bowel motion and explore the feasibility of using peritoneal space (PS) to replace bowel loops (BL) via the dose constraint method to spare the small bowel during int...

Authors: Siyuan Li, Yanping Gong, Yongqiang Yang, Qi Guo, Jianjun Qian and Ye Tian

Analysis of the response time to involved-field radiotherapy in primary gastrointestinal low-grade B-cell lymphoma

Early-stage primary gastrointestinal (GI) low-grade B-cell lymphoma shows good therapeutic response to primary radiotherapy. However, there is no clear guideline for the evaluation of response to radiation the...

Authors: Kyu Hye Choi, Han Hee Lee, Seung-Eun Jung, Kyung-Sin Park, Joo-Hyun O, Young-Woo Jeon, Byung-Ock Choi and Seok-Goo Cho

The role of carbon ion radiotherapy for unresectable locally recurrent rectal cancer: a single institutional experience

Treatment for locally recurrent rectal cancer after surgery is still a challenge. With the physical and biological advantages, carbon-ion radiotherapy (CIRT) could be a choice for these patients. The purpose o...

Authors: Xin Cai, Yueyao Du, Zheng Wang, Ping Li, Zhan Yu, Qing Zhang and Zhen Zhang

Multicentre clinical radiotherapy audit in rectal cancer: results of the IROCA project

To perform a clinical audit to assess adherence to standard clinical practice for the diagnosis, treatment, and follow-up of patients undergoing radiotherapy for rectal cancer treatment in four European countr...

Authors: Magdalena Fundowicz, Artur Aguiar, Carla Lopes de Castro, Maria Glòria Torras, Letizia Deantonio, Ewelina Konstanty, Marta Kruszyna-Mochalska, Miquel Macia, Eugeni Canals, Monica Caro, Carla Pisani, Dorota Zwierzchowska, Jaume Molero, Arantxa Eraso, Joana Lencart, Carles Muñoz-Montplet…

The value of local consolidative therapy in Osimertinib-treated non-small cell lung cancer with oligo-residual disease

There was no study investigating real-world utilization and outcome of LCT in Osimertinib-treated NSCLC with oligo-residual disease. This study was to analyze the clinical value of local consolidative therapy ...

Authors: Ya Zeng, Jianjiao Ni, Fan Yu, Yue Zhou, Yang Zhao, Shuyan Li, Tiantian Guo, Li Chu, Xi Yang, Xiao Chu, Xuwei Cai and Zhengfei Zhu

High-dose carbon-ion based radiotherapy of primary and recurrent sacrococcygeal chordomas: long-term clinical results of a single particle therapy center

This study aimed to analyze the oncological long-term results and late toxicity of carbon ion-based radiotherapy (RT) of patients with sacral chordoma and to identify potential prognostic factors for local con...

Authors: Tilman Bostel, Matthias Mattke, Nils Henrik Nicolay, Thomas Welzel, Daniel Wollschläger, Sati Akbaba, Arnulf Mayer, Tanja Sprave, Jürgen Debus and Matthias Uhl

Efficacy and safety of recombinant human endostatin combined with radiotherapy or chemoradiotherapy in patients with locally advanced non-small cell lung cancer: a pooled analysis

To assess the efficacy and safety of recombinant human endostatin in combination with radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) in patients with locally advanced non-small cell lung cancer (LA-N...

Authors: Shu-Ling Zhang, Cheng-Bo Han, Li Sun, Le-Tian Huang and Jie-Tao Ma

The diagnostic value of quantitative analysis of ASL, DSC-MRI and DKI in the grading of cerebral gliomas: a meta-analysis

To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enh...

Authors: Jixin Luan, Mingzhen Wu, Xiaohui Wang, Lishan Qiao, Guifang Guo and Chuanchen Zhang

Treatment plan quality during online adaptive re-planning

Online adaptive radiotherapy is intended to prevent plan degradation caused by inter-fractional tumor volume and shape changes, but time limitations make online re-planning challenging. The aim of this study w...

Authors: Janita E. van Timmeren, Madalyne Chamberlain, Jérôme Krayenbuehl, Lotte Wilke, Stefanie Ehrbar, Marta Bogowicz, Callum Hartley, Mariangela Zamburlini, Nicolaus Andratschke, Helena Garcia Schüler, Matea Pavic, Panagiotis Balermpas, Chaehee Ryu, Matthias Guckenberger and Stephanie Tanadini-Lang

Impact of delays in radiotherapy of head and neck cancer on outcome

In head and neck cancer (HNC), the relationship between a delay in starting radiotherapy (RT) and the outcome is unclear. The aim of the present study was to determine the impact of the amount of time before t...

Authors: Barbara Žumer, Maja Pohar Perme, Simona Jereb and Primož Strojan

Myocardial deformation after radiotherapy: a layer-specific and territorial longitudinal strain analysis in a cohort of left-sided breast cancer patients (BACCARAT study)

Radiotherapy for breast cancer (BC) and its resulting cardiac exposure are associated with subclinical left ventricular dysfunction characterized by early decrease of global longitudinal strain (LS) measuremen...

Authors: Valentin Walker, Olivier Lairez, Olivier Fondard, Gaëlle Jimenez, Jérémy Camilleri, Loïc Panh, David Broggio, Marie-Odile Bernier, Dominique Laurier, Jean Ferrières and Sophie Jacob

Intra-fraction and Inter-fraction analysis of a dedicated immobilization device for intracranial radiation treatment

Immobilization devices are crucial to minimize patient positioning uncertainties in radiotherapy (RT) treatments. Accurate inter and intra-fraction motions is particularly important for intracranial and stereo...

Authors: Chin Loon Ong, Niccolò Giaj-Levra, Luca Nicosia, Vanessa Figlia, Davide Tomasini, Eric M. Franken and Filippo Alongi

In regard to Cuccia et al.: impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy

We read the article entitled “Impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy” with great interest. In that study, ...

Authors: Hamed Ghaffari, Mahmoud Navaser and Soheila Refahi

Association between the 21-gene recurrence score and isolated locoregional recurrence in stage I-II, hormone receptor-positive breast cancer

Although the 21-gene recurrence score (RS) assay is widely used to predict distant recurrence risk and benefit from adjuvant chemotherapy among women with hormone receptor-positive (HR+) breast cancer, the rel...

Authors: David D. Yang, Daniela L. Buscariollo, Angel M. Cronin, Shicheng Weng, Melissa E. Hughes, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Stephen B. Edge, Beverly Moy, Joyce C. Niland, Antonio C. Wolff, Michael J. Hassett and Rinaa S. Punglia

Oncometabolites and the response to radiotherapy

Radiotherapy (RT) is applied in 45–60% of all cancer patients either alone or in multimodal therapy concepts comprising surgery, RT and chemotherapy. However, despite technical innovations approximately only 5...

Authors: Kexu Xiang, Verena Jendrossek and Johann Matschke

Preservation of swallowing in resected oral cavity squamous cell carcinoma: examining radiation volume effects (PRESERVE): study protocol for a randomized phase II trial

Patients with resected oral cavity squamous cell carcinoma (OCSCC) are often treated with adjuvant radiation (RT) ± concomitant chemotherapy based on pathological findings. Standard RT volumes include all surg...

Authors: Pencilla Lang, Jessika Contreras, Noah Kalman, Claire Paterson, Houda Bahig, Astrid Billfalk-Kelly, Sinead Brennan, Kathy Rock, Nancy Read, Varagur Venkatesan, Jinka Sathya, Lucas C. Mendez, S. Danielle MacNeil, Anthony C. Nichols, Kevin Fung, Adrian Mendez…

Clinical impact of Hypofractionated carbon ion radiotherapy on locally advanced hepatocellular carcinoma

Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon i...

Authors: Shintaro Shiba, Kei Shibuya, Masahiko Okamoto, Shohei Okazaki, Shuichiro Komatsu, Yoshiki Kubota, Takashi Nakano and Tatsuya Ohno

Missed radiation therapy sessions in first three weeks predict distant metastasis and less favorable outcomes in surgically treated patients with oral cavity squamous cell carcinoma

We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).

Authors: Yin-Yin Chiang, Yung-Chih Chou, Kai-Ping Chang, Chun-Ta Liao, Yao-Yu Wu, Wing-Keen Yap, Ping-Ching Pai, Joseph Tung-Chieh Chang, Chien-Yu Lin, Kang-Hsing Fan, Bing-Shen Huang, Tsung-Min Hung and Ngan-Ming Tsang