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  1. Delineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep learning-based methods can accelerate and partially automate this task. The...

    Authors: Michael Lempart, Martin P. Nilsson, Jonas Scherman, Christian Jamtheim Gustafsson, Mikael Nilsson, Sara Alkner, Jens Engleson, Gabriel Adrian, Per Munck af Rosenschöld and Lars E. Olsson
    Citation: Radiation Oncology 2022 17:114
  2. To validate tumor volume-based imaging markers for predicting local recurrence-free survival (LRFS) in locoregionally advanced nasopharyngeal carcinoma patients, who underwent induction chemotherapy followed b...

    Authors: Ge Yan, Yan Feng, Mingyao Wu, Chao Li, Yiran Wei, Li Hua, Guoqi Zhao, Zhekai Hu, Shengyu Yao, Lingtong Hou, Xuming Chen, Qianqian Liu and Qian Huang
    Citation: Radiation Oncology 2022 17:111
  3. To determine PTV margins for intrafraction motion in MRI-guided online adaptive radiotherapy for rectal cancer and the potential benefit of performing a 2nd adaptation prior to irradiation.

    Authors: Chavelli M. Kensen, Tomas M. Janssen, Anja Betgen, Lisa Wiersema, Femke P. Peters, Peter Remeijer, Corrie A. M. Marijnen and Uulke A. van der Heide
    Citation: Radiation Oncology 2022 17:110
  4. To analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union Hospital Cancer Center.

    Authors: Meng-Lan Zhai, Fang-Yuan Zhang, Jin-Ru Yang, Sheng Zhang, Lei Zhao, Zhen-Yu Lin, Jing Wang, Dan-Dan Yu and Tao Zhang
    Citation: Radiation Oncology 2022 17:109
  5. Up to 30% of pancreatic cancer patients initially present locally advanced (LAPC). Stereotactic body radiation therapy (SBRT) may be an additional palliative treatment option when curative resection is no long...

    Authors: Marlies Vornhülz, Sofia Anton, Balint Eross, Zsolt Szakács, Peter Hegyi, Ivonne Regel, Claus Belka, Maximilian Niyazi, Julia Mayerle and Georg Beyer
    Citation: Radiation Oncology 2022 17:108
  6. The prescribed radiation dose to patients with oropharyngeal squamous cell carcinoma (OPSCC) is standardized, even if the prognosis for individual patients may differ. Easy-at-hand pre-treatment risk stratific...

    Authors: Gabriel Adrian, Henrik Carlsson, Elisabeth Kjellén, Johanna Sjövall, Björn Zackrisson, Per Nilsson and Maria Gebre-Medhin
    Citation: Radiation Oncology 2022 17:107
  7. The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepato...

    Authors: Jian-Xu Li, Wen-Xiang Deng, Shi-Ting Huang, Xiao-Feng Lin, Mei-Ying Long, Jie Zhang, Ting-Shi Su, Li-Qing Li, Ya-Dan Pang, Chun-Feng Liang, Hong-Mei Zhou, Hai-Yan Lu, Shi-Xiong Liang and Bang-De Xiang
    Citation: Radiation Oncology 2022 17:106
  8. This trial aims to explore the efficacy and safety of involved-field irradiation (IFI) combined with paclitaxel plus cisplatin as concurrent chemoradiotherapy for locally advanced esophageal squamous cell carc...

    Authors: Hui Li, Ying Fang, Dayong Gu, Mingyu Du, Zhi Zhang, Lei Sun, Guoren Zhou and Jinjun Ye
    Citation: Radiation Oncology 2022 17:105
  9. To propose a specific surface guided stereotactic radiotherapy (SRT) treatment procedure with open-face mask immobilization and evaluate the initial clinical experience in improving setup accuracy.

    Authors: Shun Zhou, Junyu Li, Xianggao Zhu, Yi Du, Songmao Yu, Meijiao Wang, Kaining Yao, Hao Wu and Haizhen Yue
    Citation: Radiation Oncology 2022 17:104
  10. Surgical resection with adjuvant concurrent radiochemotherapy is the standard of care for stage III–IV oral cavity cancer. In some cases, the dynamic course of the disease is out of the prepared schedule of tr...

    Authors: Paweł Polanowski, Agnieszka Pietruszka, Dorota Księżniak-Baran, Aleksandra Grządziel, Ewa Chmielik, Marek Kentnowski, Natalia Amrogowicz, Krzysztof Składowski and Katarzyna Polanowska
    Citation: Radiation Oncology 2022 17:103
  11. Stereotactic Body Radiotherapy (SBRT) is a standard treatment for inoperable primary and secondary lung tumors. In case of ultracentral tumor location, defined as tumor contact with vulnerable mediastinal stru...

    Authors: Sebastian Regnery, Jonas Ristau, Fabian Weykamp, Philipp Hoegen, Simon David Sprengel, Katharina Maria Paul, Carolin Buchele, Sebastian Klüter, Carolin Rippke, Claudia Katharina Renkamp, Moritz Pohl, Jan Meis, Thomas Welzel, Sebastian Adeberg, Stefan Alexander Koerber, Jürgen Debus…
    Citation: Radiation Oncology 2022 17:102
  12. We investigated the prognostic impact of the neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced rectal cancer (LARC) and whether modifiable factors in radiotherapy (RT) influenced the NLR.

    Authors: Gowoon Yang, Jee Suk Chang, Jeong Eun Choi, Eun Sil Baek, Seung-Seob Kim, Hwa Kyung Byun, Yeona Cho, Woong Sub Koom, Seung Yoon Yang, Byung Soh Min and Sang Joon Shin
    Citation: Radiation Oncology 2022 17:100
  13. Due to respiratory motion, accurate radiotherapy delivery to thoracic and abdominal tumors is challenging. We aimed to quantify the ability of mechanical ventilation to reduce respiratory motion, by measuring ...

    Authors: Z. van Kesteren, J. K. Veldman, M. J. Parkes, M. F. Stevens, P. Balasupramaniam, J. G. van den Aardweg, G. van Tienhoven, A. Bel and I. W. E. M. van Dijk
    Citation: Radiation Oncology 2022 17:99

    The Correction to this article has been published in Radiation Oncology 2022 17:113

  14. High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rare...

    Authors: Qiao-Xuan Wang, Shu Zhang, Wei-Wei Xiao, Cheng-Jing Zhou, Hui Chang, Zhi-Fan Zeng, Pei-Qiang Cai, Zhen-Hai Lu, Gong Chen, Pei-Rong Ding, Zhi-Zhong Pan, Xiao-Jun Wu and Yuan-Hong Gao
    Citation: Radiation Oncology 2022 17:98
  15. Radium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to the first skeletal-related event, reduce the rate of hospitalization, an...

    Authors: Julie R. Bloom, Alexandra G. Castillejos, Brianna Jones, Nimesh Patel, Barry S. Rosenstein and Richard G. Stock
    Citation: Radiation Oncology 2022 17:97
  16. This study aimed to explore the pattern of locoregional recurrence after surgery in patients with non-metastatic stage pT4 sigmoid colon cancer and the role of adjuvant radiotherapy on survival.

    Authors: Yaobin Lin, Shan Liu, Liang Hong, Lingdong Shao and Junxin Wu
    Citation: Radiation Oncology 2022 17:95
  17. To assess the feasibility of postoperative stereotactic body radiation therapy (SBRT) for patients with hybrid implants consisting of carbon fiber reinforced polyetheretherketone and titanium (CFP-T) using Cyb...

    Authors: Dominik Henzen, Daniel Schmidhalter, Gian Guyer, Anna Stenger-Weisser, Ekin Ermiş, Robert Poel, Moritz Caspar Deml, Michael Karl Fix, Peter Manser, Daniel Matthias Aebersold and Hossein Hemmatazad
    Citation: Radiation Oncology 2022 17:94
  18. In most of the views, rectal stenosis after anterior resection for rectal cancer results from pelvic radiotherapy. However, patients without receiving radiotherapy also suffer stenosis. In this study, we evalu...

    Authors: Hui Zhang, Shanshan Li, Xin Jin, Xian Wu, Zhiyuan Zhang, Lijun Shen, Juefeng Wan, Yan Wang, Yaqi Wang, Wang Yang, Menglong Zhou, Jing Zhang, Tao Lv, Yun Deng, Fan Xia and Zhen Zhang
    Citation: Radiation Oncology 2022 17:93
  19. Established prognostic models, such as the diagnosis-specific graded prognostic assessment, were not designed to specifically address very short survival. Therefore, a brain metastases-specific 30-day mortalit...

    Authors: Carsten Nieder, Luka Stanisavljevic, Siv Gyda Aanes, Bård Mannsåker and Ellinor Christin Haukland
    Citation: Radiation Oncology 2022 17:92
  20. To analyze the prognostic factors associated with stage IB-IVA cervical cancer in patients who underwent concurrent chemoradiation therapy (CCRT) and to compare the clinical toxicities and dosimetric parameter...

    Authors: Yuan-Kai Cheng, Shih-Hsun Kuo, Heng-Hsuan Yen, Jing-Hu Wu, Yu-Chieh Chen and Ming-Yii Huang
    Citation: Radiation Oncology 2022 17:91
  21. Prostate cancer is the second most common malignancy worldwide, and the majority of patients are diagnosed with localized disease. We examined patients’ quality of life after stereotactic body radiation therap...

    Authors: Hideomi Yamashita, Mami Ogita, Subaru Sawayanagi, Yuki Nozawa and Osamu Abe
    Citation: Radiation Oncology 2022 17:90
  22. Recently, stereotacitc radiosurgery (SRS) has been in the spotlight as an alternative therapeutic option for jugular foramen schwannomas (JFS). While most reported studies focus on the long-term efficacy and s...

    Authors: Young Goo Kim, Chang Kyu Park, Na Young Jung, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang and Won Seok Chang
    Citation: Radiation Oncology 2022 17:89
  23. Contact lens-type ocular in vivo dosimeters (CLODs) were recently developed as the first in vivo dosimeter that can be worn directly on the eye to measure the dose delivered to the lens during radiotherapy. Ho...

    Authors: Jaeman Son, Jin Dong Cho, Seongmoon Jung, Chang Heon Choi, Jong Min Park and Jung-in Kim
    Citation: Radiation Oncology 2022 17:88
  24. A new compact superconducting synchrocyclotron single-room proton solution delivers pulsed proton beams to each spot through several irradiation bursts calculated by an iterative layer delivery algorithm. Such...

    Authors: Lewei Zhao, Gang Liu, Shupeng Chen, Jiajian Shen, Weili Zheng, An Qin, Di Yan, Xiaoqiang Li and Xuanfeng Ding
    Citation: Radiation Oncology 2022 17:87
  25. This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 meta...

    Authors: Yuan Xu, Yingjie Xu, Kuo Men, Jianping Xiao and Jianrong Dai
    Citation: Radiation Oncology 2022 17:86
  26. We sought to clarify the optimal follow-up, therapeutic strategy, especially the role of reirradiation, and the diagnostic impact of isocitrate dehydrogenase (IDH) 1 and 2 mutation status in patients with radiati...

    Authors: Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Shunsuke Yanagisawa, Yukie Tamura, Daisuke Kawauchi, Miyu Kikuchi, Hiroshi Igaki, Akihiko Yoshida, Kaishi Satomi, Yuko Matsushita, Koichi Ichimura and Yoshitaka Narita
    Citation: Radiation Oncology 2022 17:85
  27. To report on the discriminative ability of a simulation Computed Tomography (CT)-based radiomics signature for predicting response to treatment in patients undergoing neoadjuvant chemo-radiation for locally ad...

    Authors: Pierluigi Bonomo, Jairo Socarras Fernandez, Daniela Thorwarth, Marta Casati, Lorenzo Livi, Daniel Zips and Cihan Gani
    Citation: Radiation Oncology 2022 17:84
  28. Adjuvant radiation therapy improves the overall survival and loco-regional control in patients with breast cancer. However, radiation-induced heart disease, which occurs after treatment from incidental radiati...

    Authors: Jaehee Chun, Jee Suk Chang, Caleb Oh, InKyung Park, Min Seo Choi, Chae-Seon Hong, Hojin Kim, Gowoon Yang, Jin Young Moon, Seung Yeun Chung, Young Joo Suh and Jin Sung Kim
    Citation: Radiation Oncology 2022 17:83
  29. Robotic linac is ideally suited to deliver hypo-fractionated radiotherapy due to its compact head and flexible positioning. The non-coplanar treatment space improves the delivery versatility but the complexity...

    Authors: Bin Liang, Ran Wei, Jianghu Zhang, Yongbao Li, Tao Yang, Shouping Xu, Ke Zhang, Wenlong Xia, Bin Guo, Bo Liu, Fugen Zhou, Qiuwen Wu and Jianrong Dai
    Citation: Radiation Oncology 2022 17:82
  30. To gain insight into the treatment outcomes for anal cancer a retrospective analysis was performed with a special emphasis on trends in outcome and toxicities over time and on treatment of elderly patients.

    Authors: Karen J. Neelis, Django M. Kip, Frank M. Speetjens and Yvette M. van der Linden
    Citation: Radiation Oncology 2022 17:81
  31. Moderately hypofractionated whole-breast radiotherapy (HFRT) has proven to be as safe and efficient as normofractionated radiotherapy (NFRT) in randomized trials resulting in major changes in clinical practice...

    Authors: Irfane Issoufaly, Claire Petit, Sébastien Guihard, Rémi Eugène, Loic Jung, Jean Baptiste Clavier, Stéphanie Servagi Vernat, Sara Bellefqih, Benjamin Verret, Naïma Bonnet, Éric Deutsch and Sofia Rivera
    Citation: Radiation Oncology 2022 17:80
  32. Inherent resistance to radio/chemotherapy is one of the major reasons for early recurrence, treatment failure, and dismal prognosis of glioblastoma. Thus, the identification of resistance driving regulators as...

    Authors: Leon Emanuel Schnöller, Valerie Albrecht, Nikko Brix, Alexander Edward Nieto, Daniel Felix Fleischmann, Maximilian Niyazi, Julia Hess, Claus Belka, Kristian Unger, Kirsten Lauber and Michael Orth
    Citation: Radiation Oncology 2022 17:79
  33. Predicting pathological complete response (pCR) in patients affected by locally advanced rectal cancer (LARC) who undergo neoadjuvant chemoradiotherapy (nCRT) is a challenging field of investigation, but many ...

    Authors: Luca Boldrini, Jacopo Lenkowicz, Lucia Clara Orlandini, Gang Yin, Davide Cusumano, Giuditta Chiloiro, Nicola Dinapoli, Qian Peng, Calogero Casà, Maria Antonietta Gambacorta, Vincenzo Valentini and Jinyi Lang
    Citation: Radiation Oncology 2022 17:78
  34. There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect ob...

    Authors: Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar…
    Citation: Radiation Oncology 2022 17:77
  35. The irradiation of breast cancer patients with included internal mammary lymph nodes challenges radiation planning with regard to robustness and protection of OARs. In this publication, a feasible hybrid radia...

    Authors: Marina Hennet, Stephan Radonic, Uwe Schneider and Matthias Hartmann
    Citation: Radiation Oncology 2022 17:76
  36. Normofractionated radiation regimes for definitive prostate cancer treatment usually extend over 7–8 weeks. Recently, moderate hypofractionation with doses per fraction between 2.2 and 4 Gy has been shown to b...

    Authors: J. Ristau, J. Hörner-Rieber, C. Buchele, S. Klüter, C. Jäkel, L. Baumann, N. Andratschke, H. Garcia Schüler, M. Guckenberger, M. Li, M. Niyazi, C. Belka, K. Herfarth, J. Debus and S. A. Koerber
    Citation: Radiation Oncology 2022 17:75
  37. There are limited data on survival prediction models in contemporary inoperable non-small cell lung cancer (NSCLC) patients. The objective of this study was to develop and validate a survival prediction model ...

    Authors: Natalie Si-Yi Lee, Jesmin Shafiq, Matthew Field, Caroline Fiddler, Suganthy Varadarajan, Senthilkumar Gandhidasan, Eric Hau and Shalini Kavita Vinod
    Citation: Radiation Oncology 2022 17:74
  38. Radiotherapy (RT) is part of the curative treatment of approximately 70% of breast cancer (BC) patients. Wide practice variation has been reported in RT dose, fractionation and its treatment planning for BC. T...

    Authors: Nansi Maliko, Marcel R. Stam, Liesbeth J. Boersma, Marie-Jeanne T. F. D. Vrancken Peeters, Michel W. J. M. Wouters, Eline KleinJan, Maurice Mulder, Marion Essers, Coen W. Hurkmans and Nina Bijker
    Citation: Radiation Oncology 2022 17:73
  39. Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for...

    Authors: Simon Deycmar, Elisabeth Mara, Sylvia Kerschbaum-Gruber, Verena Waller, Dietmar Georg and Martin Pruschy
    Citation: Radiation Oncology 2022 17:72
  40. We compared the oncological outcomes of patients who received seed brachytherapy (SEED-BT) with those who received radical prostatectomy (RP) for intermediate-risk prostate cancer.

    Authors: Hideyasu Tsumura, Nobumichi Tanaka, Tomohiko Oguchi, Takuya Owari, Yasushi Nakai, Isao Asakawa, Kazuyoshi Iijima, Haruaki Kato, Iwao Hashida, Ken-ichi Tabata, Takefumi Satoh and Hiromichi Ishiyama
    Citation: Radiation Oncology 2022 17:71
  41. To quantify the pelvic bone marrow (PBM) fat content changes receiving different radiation doses of concurrent chemoradiotherapy for cervical cancer and to determine association with peripheral blood cell counts.

    Authors: Cong Wang, Xiaohang Qin, Guanzhong Gong, Lizhen Wang, Ya Su and Yong Yin
    Citation: Radiation Oncology 2022 17:70
  42. Four-dimensional cone-beam computed tomography (4D-CBCT) can visualize moving tumors, thus adaptive radiation therapy (ART) could be improved if 4D-CBCT were used. However, 4D-CBCT images suffer from severe im...

    Authors: Keisuke Usui, Koichi Ogawa, Masami Goto, Yasuaki Sakano, Shinsuke Kyougoku and Hiroyuki Daida
    Citation: Radiation Oncology 2022 17:69
  43. Curative treatment of inoperable post-irradiation sarcoma is often challenging, especially using radiotherapy, wherein curative dose administration is difficult because the organs around the tumor have already...

    Authors: Shintaro Shiba, Masahiko Okamoto, Takashi Yanagawa, Isaku Kohama, Kei Shibuya, Shohei Okazaki, Yuhei Miyasaka, Hirotaka Chikuda and Tatsuya Ohno
    Citation: Radiation Oncology 2022 17:68
  44. To report results from our phase II study of stereotactic body radiotherapy (SBRT) delivering 36 Gy in 4 fractions for patients with localized prostate cancer.

    Authors: S. Kawakami, H. Tsumura, T. Satoh, K. Tabata, A. Sekiguchi, T. Kainuma, M. Nakano, M. Iwamura and H. Ishiyama
    Citation: Radiation Oncology 2022 17:67
  45. The use of treatment planning prostate MRI for Stereotactic Body Radiation Therapy (SBRT) is largely a standard, yet not all patients can receive MRI for a variety of clinical reasons. Thus, we aim to investig...

    Authors: Katherine Amarell, Anna Jaysing, Christopher Mendez, Jonathan A. Haas, Seth R. Blacksburg, Aaron E. Katz, Astrid Sanchez, Angela Tong, Todd Carpenter, Matthew Witten, Sean P. Collins and Jonathan W. Lischalk
    Citation: Radiation Oncology 2022 17:66
  46. Automatic prostate tumor segmentation is often unable to identify the lesion even if multi-parametric MRI data is used as input, and the segmentation output is difficult to verify due to the lack of clinically...

    Authors: Deepa Darshini Gunashekar, Lars Bielak, Leonard Hägele, Benedict Oerther, Matthias Benndorf, Anca-L. Grosu, Thomas Brox, Constantinos Zamboglou and Michael Bock
    Citation: Radiation Oncology 2022 17:65

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