Articles

Voxel-level biological optimisation of prostate IMRT using patient-specific tumour location and clonogen density derived from mpMRI

This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework include...

Authors: E. J. Her, A. Haworth, H. M. Reynolds, Y. Sun, A. Kennedy, V. Panettieri, M. Bangert, S. Williams and M. A. Ebert

Exploring MR regression patterns in rectal cancer during neoadjuvant radiochemotherapy with daily T2- and diffusion-weighted MRI

To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...

Authors: T. Bostel, C. Dreher, D. Wollschläger, A. Mayer, F. König, S. Bickelhaupt, H. P. Schlemmer, P. E. Huber, F. Sterzing, P. Bäumer, J. Debus and N. H. Nicolay

Accuracy of real-time respiratory motion tracking and time delay of gating radiotherapy based on optical surface imaging technique

Surface-guided radiation therapy (SGRT) employs a non-invasive real-time optical surface imaging (OSI) technique for patient surface motion monitoring during radiotherapy. The main purpose of this study is to ...

Authors: Li Chen, Sen Bai, Guangjun Li, Zhibin Li, Qing Xiao, Long Bai, Changhu Li, Lixun Xian, Zhenyao Hu, Guyu Dai and Guangyu Wang

The impact of scanning data measurements on the Acuros dose calculation algorithm configuration

Many dose calculation algorithms for radiotherapy planning need to be configured for each clinical beam using pre-defined measurements. An optimization process adjusts the physical parameters able to estimate ...

Authors: A. Fogliata, E. Esposito, L. Paganini, G. Reggiori, S. Tomatis, M. Scorsetti and L. Cozzi

Dosimetric effects of adaptive prostate cancer radiotherapy in an MR-linac workflow

The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (M...

Authors: Annika Mannerberg, Emilia Persson, Joakim Jonsson, Christian Jamtheim Gustafsson, Adalsteinn Gunnlaugsson, Lars E. Olsson and Sofie Ceberg

Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy

Immune-checkpoint inhibitors (ICI) have dramatically changed the landscape of lung cancer treatment. Preclinical studies investigating combination of ICI with radiation show a synergistic improvement of tumor ...

Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Maurice Dantes, Nina-Sophie Schmidt-Hegemann, Sanziana Schiopu, Claus Belka and Farkhad Manapov

Radiotherapy after the easing of public restrictions during COVID-19 epidemic

The daily new confirmed Coronavirus disease 2019 (COVID-19) cases have decreased in some European and Asian countries. Many countries and areas have started to ease public restrictions. Here, we share our expe...

Authors: Weiping Wang, Ke Hu, Jie Qiu and Fuquan Zhang

SARS-CoV-2 prevalence in an asymptomatic cancer cohort - results and consequences for clinical routine

Starting in December 2019, the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confronts the world with an unprecedented challenge. With no vaccine or drug being cur...

Authors: Sebastian Marschner, Stefanie Corradini, Josefine Rauch, Richard Zacharias, Ana Sujic, Julia Mayerle, Raluca Petru, Béatrice Grabein, Oliver T. Keppler, Edwin Boelke, Claus Belka and Maximilian Niyazi

Online adaptive radiotherapy compared to plan selection for rectal cancer: quantifying the benefit

To compare online adaptive radiation therapy (ART) to a clinically implemented plan selection strategy (PS) with respect to dose to the organs at risk (OAR) for rectal cancer.

Authors: R. de Jong, K. F. Crama, J. Visser, N. van Wieringen, J. Wiersma, E. D. Geijsen and A. Bel

Dosimetric comparison between RapidArc and HyperArc techniques in salvage stereotactic body radiation therapy for recurrent nasopharyngeal carcinoma

To evaluate dosimetric differences of salvage irradiations using two commercially available volumetric modulated arc therapy (VMAT) stereotactic body radiation therapy (SBRT) techniques: RapidArc (RA) and Hype...

Authors: Hsiu-Wen Ho, Steve P. Lee, Hisu-Man Lin, Hsiao-Yun Chen, Chun-Chiao Huang, Shih-Chang Wang, Ching-Chieh Yang and Yu-Wei Lin

Magnetic resonance-guided radiation therapy: the beginning of a new era

Authors: Guillaume Landry, Stefanie Corradini and Claus Belka

Study on the ability of 3D gamma analysis and bio-mathematical model in detecting dose changes caused by dose-calculation-grid-size (DCGS)

To explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).

Authors: Han Bai, Sijin Zhu, Xingrao Wu, Xuhong Liu, Feihu Chen and Jiawen Yan

Can neoadjuvant chemotherapy improve survival in stage T3-4N1 nasopharyngeal carcinoma? A propensity matched analysis

To estimate the efficacy of neoadjuvant chemotherapy (NCT) in stage T3-4N1 nasopharyngeal carcinoma (NPC).

Authors: Lei Wang, Zheng Wu, Dehuan Xie, Shaowen Lv, Liangping Xia and Yong Su

Proton versus photon radiotherapy for primary hepatocellular carcinoma: a propensity-matched analysis

Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton radiotherapy in treating hepatocellular carcinoma (HCC). However, cl...

Authors: Jen-Yu Cheng, Chieh-Min Liu, Yu-Ming Wang, Hsuan-Chih Hsu, Eng-Yen Huang, Tzu-Ting Huang, Ching-Hsin Lee, Sheng-Ping Hung and Bing-Shen Huang

Oncologic outcomes of pre- versus post-operative radiation in Resectable soft tissue sarcoma: a systematic review and meta-analysis

Postoperative radiation therapy for soft tissue sarcomas demonstrated good local recurrence-free survival rates and survival outcomes. However, the results remained controversial. This study aimed to evaluate ...

Authors: Xinmiao Yang, Lihua Zhang, Xiaojing Yang, Weiwei Yu and Jie Fu

Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head

The purpose of this study was to determine the potential of escalated dose radiation (EDR) robust intensity-modulated proton radiotherapy (ro-IMPT) in reducing GI toxicity risk in locally advanced unresectable...

Authors: Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano and Tetsuo Akimoto

Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy

The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory o...

Authors: Yun-Hsuan Lin, Shih-Ming Huang, Wing-Keen Yap, Ju-Wen Yang, Ling Yeung, Din-Li Tsan, Joseph Tung-Chieh Chang and Lung-Chien Chen

Radiotherapy combined with gefitinib for patients with locally advanced non-small cell lung cancer who are unfit for surgery or concurrent chemoradiotherapy: a phase II clinical trial

The objectives of this study were to determine the objective effective response rate, survival, and safety of radiotherapy combined with gefitinib in patients with locally advanced non-small cell lung cancer (...

Authors: Zhixue Fu, Xu Yang, Wenqing Wang, Lei Deng, Tao Zhang, Nan Bi, Xiaozhen Wang, Dongfu Chen, Zongmei Zhou, Luhua Wang and Jun Liang

Radioprotective efficacy of plastic polymer against the toxicogenomic effects of radiopharmaceutical ¹⁸F-FDG on human lymphocytes

Healthcare workers occupationally exposed to ¹⁸F-FDG cannot wear protective equipment, such as lead aprons, since the interaction between high energy radiation (511 keV) and metal increases the dose of radiation ...

Authors: Nilson Benedito Lopes, Igor Vivian Almeida, Pedro Henrique Silvestre Lopes and Veronica Elisa Pimenta Vicentini

Impact of HIV infection on consolidative radiotherapy for non-Hodgkin diffuse large B-cell lymphoma

Even though frequent, it is not known how HIV infection and treatment impact in the consolidation by radiotherapy of non-Hodgkin diffuse large B-cell lymphomas (DBCL). This article aim to assess that differenc...

Authors: Carolina Trindade Mello Medici, Geovanne Pedro Mauro, Lucas Coelho Casimiro and Eduardo Weltman

Reliability of ITV approach to varying treatment fraction time: a retrospective analysis based on 2D cine MR images

Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT).

Authors: Davide Cusumano, Jennifer Dhont, Luca Boldrini, Giuditta Chiloiro, Angela Romano, Claudio Votta, Silvia Longo, Lorenzo Placidi, Luigi Azario, Marco De Spirito, Dirk Verellen and Vincenzo Valentini

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)

Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxici...

Authors: Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan and Maria A. Hawkins

Clinical implication in the use of the AAA algorithm versus the AXB in nasopharyngeal carcinomas by comparison of TCP and NTCP values

Retrospective analysis of volumetric modulated arc therapy treatment plans to investigate qualitative, possible, clinical consequences of the use of AAA versus AXB in nasopharyngeal cancer (NPC) cases.

Authors: Antonella Bufacchi, Orietta Caspiani, Giulia Rambaldi, Luca Marmiroli, Giuseppe Giovinazzo and Mattia Polsoni

Residual positioning errors and uncertainties for pediatric craniospinal irradiation and the impact of image guidance

Optimal alignment is of utmost importance when treating pediatric patients with craniospinal irradiation (CSI), especially with regards to field junctions and multiple isocenters and techniques applying high d...

Authors: Daniel Gram, André Haraldsson, N. Patrik Brodin, Karsten Nysom, Thomas Björk-Eriksson and Per Munck af Rosenschöld

Pattern-of-failure and salvage treatment analysis after chemoradiotherapy for inoperable stage III non-small cell lung cancer

Loco-regional and distant failure are common in inoperable stage III non small-cell lung cancer (NSCLC) after chemoradiotherapy (CRT). However, there is limited real-world data on failure pattern, patient prog...

Authors: Julian Taugner, Chukwuka Eze, Lukas Käsmann, Olarn Roengvoraphoj, Kathrin Gennen, Monika Karin, Oleg Petrukhnov, Amanda Tufman, Claus Belka and Farkhad Manapov

Overlapping volumes in re-irradiation for head and neck cancer – an important factor for patient selection

There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the r...

Authors: Anna Embring, Eva Onjukka, Claes Mercke, Ingmar Lax, Anders Berglund, Sara Bornedal, Berit Wennberg and Signe Friesland

A novel three-dimensional template combined with MR-guided ¹²⁵I brachytherapy for recurrent glioblastoma

At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide ¹²⁵I seed implantation f...

Authors: Xiangmeng He, Ming Liu, Menglong Zhang, Roberto Blanco Sequeiros, Yujun Xu, Ligang Wang, Chao Liu, Qingwen Wang, Kai Zhang and Chengli Li

Survival after hypofractionation in glioblastoma: a systematic review and meta-analysis

Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been test...

Authors: Jane-Chloe Trone, Alexis Vallard, Sandrine Sotton, Majed Ben Mrad, Omar Jmour, Nicolas Magné, Benjamin Pommier, Silvy Laporte and Edouard Ollier

The effect of radiotherapy on taste sensation in head and neck cancer patients – a prospective study

One of the main side effects of head and neck (H&N) radiation therapy (RT) is alteration in taste sensation. It causes significant morbidity and has a major effect on quality of life (QoL). The aim of this stu...

Authors: Michal Asif, Assaf Moore, Noam Yarom and Aron Popovtzer

Radiotherapy in the treatment of aggressive fibromatosis: experience from a single institution

Desmoid-type fibromatosis is a rare, potentially locally aggressive disease. Herein we present our experience in the treatment with radiotherapy.

Authors: K. Seidensaal, S. B. Harrabi, F. Weykamp, K. Herfarth, T. Welzel, G. Mechtersheimer, B. Lehner, M. Schneider, S. Fröhling, G. Egerer, J. Debus and M. Uhl

Dosimetric parameters predict radiation-induced choanal stenosis in patients with nasopharyngeal carcinoma

Radiation-induced choanal stenosis (RICS) severely decreases life quality of patients with nasopharyngeal carcinoma (NPC) and originates from nasal mucositis, which depends on radiation dose. This self-control...

Authors: Hui Chang, Kai Chen, Ya-lan Tao, Fei Han, Wei-jun Ye and Yuan-hong Gao

Impact of mouse strain and sex when modeling radiation necrosis

Murine models are among the most common type of preclinical animal models used to study the human condition, but a wide selection of different mice is currently in use with these differences potentially compro...

Authors: Andrew J. Boria and Carlos J. Perez-Torres

Shift in indications for radiotherapy during the COVID-19 pandemic? A review of organ-specific cancer management recommendations from multidisciplinary and surgical expert groups

To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on th...

Authors: Dirk Vordermark

The impact of immunotherapy on the survival of pancreatic adenocarcinoma patients who received definitive surgery of the pancreatic tumor: a retrospective analysis of the National Cancer Database

Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma (PDAC), and its therapeutic role remains unclear. The objective of t...

Authors: Saber Amin, Michael Baine, Jane Meza, Morshed Alam and Chi Lin

PITChing (professional organisations, innovative trial designs and collaborative approach) for evidence generation for proton therapy

Developments in the field of proton beam therapy (PBT) have recently crossed the tipping point wherein the modality is now more versatile than ever before, with possibilities and likely indications expanding r...

Authors: Srinivas Chilukuri, Pankaj Kumar Panda and Rakesh Jalali

Detection and dynamics of circulating tumor cells in patients with high-risk prostate cancer treated with radiotherapy and hormones: a prospective phase II study

Circulating tumor cells (CTCs) are an established prognostic marker in castration-resistant prostate cancer but have received little attention in localized high-risk disease. We studied the detection rate of C...

Authors: Almudena Zapatero, Antonio Gómez-Caamaño, María Ángeles Cabeza Rodriguez, Laura Muinelo-Romay, Carmen Martin de Vidales, Alicia Abalo, Patricia Calvo Crespo, Luis Leon Mateos, Carlos Olivier and Lorena Vega Vega Piris

PET/CT of breast cancer regional nodal recurrences: an evaluation of contouring atlases

To validate the Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast cancer nodal clinical target volumes (CTVs) and to investigate the Radiotherapy Compara...

Authors: Laura Beaton, Luminita Nica, Scott Tyldesley, Kenny Sek, Gareth Ayre, Maria Aparicio, Lovedeep Gondara, Caroline Speers and Alan Nichol

Predicting survival in melanoma patients treated with concurrent targeted- or immunotherapy and stereotactic radiotherapy

Melanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed treatment of stereotactic radiotherapy (SRT) and whole brain radiotherapy (W...

Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…

Fatigue following radiotherapy of low-risk early breast cancer – a randomized controlled trial of intraoperative electron radiotherapy versus standard hypofractionated whole-breast radiotherapy: the COSMOPOLITAN trial (NCT03838419)

Fatigue is one of the most common and distressing side-effects of breast cancer radiotherapy. According to current guidelines, accelerated partial breast irradiation (APBI) may be considered as an alternative ...

Authors: Tobias Forster, Cornelia Jäkel, Sati Akbaba, David Krug, Robert Krempien, Matthias Uhl, Matthias Felix Häfner, Laila König, Stefan Alexander Koerber, Semi Harrabi, Denise Bernhardt, Rouven Behnisch, Johannes Krisam, Andre Hennigs, Christof Sohn, Jörg Heil…

Effectiveness of salvage radiotherapy for superficial esophageal Cancer after non-curative endoscopic resection

Endoscopic resection is widely used as an effective treatment for superficial esophageal cancer. However, the risk of lymph node metastasis increases in cases of muscularis mucosae or deeper invasion, for whic...

Authors: Ikuno Nishibuchi, Yuji Murakami, Yoshinori Adachi, Nobuki Imano, Yuki Takeuchi, Ippei Tkahashi, Tomoki Kimura, Yuji Urabe, Shiro Oka, Shinji Tanaka and Yasushi Nagata

Early circulating tumour DNA kinetics measured by ultra-deep next-generation sequencing during radical radiotherapy for non-small cell lung cancer: a feasibility study

The evaluation of circulating tumour DNA (ctDNA) from clinical blood samples, liquid biopsy, offers several diagnostic advantages compared with traditional tissue biopsy, such as shorter processing time, reduc...

Authors: G. M. Walls, L. McConnell, J. McAleese, P. Murray, T. B. Lynch, K. Savage, G. G. Hanna and D. Gonzalez de Castro

Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription

Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) is upregulated in CC cells upon radia...

Authors: Jing-Jie Zheng, Yue He, Yang Liu, Feng-Shuang Li, Zhen Cui, Xiao-Meng Du, Chun-Peng Wang and Yu-Mei Wu

On the pitfalls of PTV in lung SBRT using type-B dose engine: an analysis of PTV and worst case scenario concepts for treatment plan optimization

PTV concept is presumed to introduce excessive and inconsistent GTV dose in lung stereotactic body radiotherapy (SBRT). That GTV median dose prescription (D₅₀) and robust optimization are viable PTV–free solution...

Authors: Ronnie Wing King Leung, Mark Ka Heng Chan, Chi-Leung Chiang, Matthew Wong and Oliver Blanck

MR-guided proton therapy: a review and a preview

The targeting accuracy of proton therapy (PT) for moving soft-tissue tumours is expected to greatly improve by real-time magnetic resonance imaging (MRI) guidance. The integration of MRI and PT at the treatmen...

Authors: Aswin Hoffmann, Bradley Oborn, Maryam Moteabbed, Susu Yan, Thomas Bortfeld, Antje Knopf, Herman Fuchs, Dietmar Georg, Joao Seco, Maria Francesca Spadea, Oliver Jäkel, Christopher Kurz and Katia Parodi

A multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis

Hypofractionated-SRS (HF-SRS) may allow for improved local control and a reduced risk of radiation necrosis compared to single-fraction-SRS (SF-SRS). However, data comparing these two treatment approaches are ...

Authors: Jill S. Remick, Emily Kowalski, Rahul Khairnar, Kai Sun, Emily Morse, Hua-Ren R. Cherng, Yannick Poirier, Narottam Lamichhane, Stewart J. Becker, Shifeng Chen, Akshar N. Patel, Young Kwok, Elizabeth Nichols, Pranshu Mohindra, Graeme F. Woodworth, William F. Regine…

Preliminary result of carbon-ion radiotherapy using the spot scanning method for prostate cancer

Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer.

Authors: Yosuke Takakusagi, Hiroyuki Katoh, Kio Kano, Wataru Anno, Keisuke Tsuchida, Nobutaka Mizoguchi, Itsuko Serizawa, Daisaku Yoshida and Tadashi Kamada

The effect of primary tumor radiotherapy in patients with Unresectable stage IV Rectal or Rectosigmoid Cancer: a propensity score matching analysis for survival

To evaluate the impact of primary tumor radiotherapy on survival in patients with unresectable metastatic rectal or rectosigmoid cancer.

Authors: Gang Wang, Wenling Wang, Haijie Jin, Hongmin Dong, Weiwei Chen, Xiaokai Li, Guodong Li and Leilei Li

Patterns of recurrence in anal cancer: a detailed analysis

Anal cancer is a rare disease, which might be the reason for the “one size fits all” approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contempo...

Authors: Martin P. Nilsson, Erik D. Nilsson, Anders Johnsson, Otilia Leon, Adalsteinn Gunnlaugsson and Jonas Scherman

Investigating the loco-regional control of simultaneous integrated boost intensity-modulated radiotherapy with different radiation fraction sizes for locally advanced non-small-cell lung cancer: clinical outcomes and the application of an extended LQ/TCP model

To investigate the loco-regional progression-free survival (LPFS) of intensity-modulated radiotherapy (IMRT) with different fraction sizes for locally advanced non-small-cell lung cancer (LANSCLC), and to appl...

Authors: Bo Qiu, Qi Wen Li, Xin Lei Ai, Bin Wang, Jian Huan, Zheng Fei Zhu, Gen Hua Yu, Ming Ji, Hai Hang Jiang, Cheng Li, Jun Zhang, Li Chen, Jin Yu Guo, Yin Zhou and Hui Liu

Hypofractionated palliative volumetric modulated arc radiotherapy with the Radiation Oncology Study Group 8502 “QUAD shot” regimen for incurable head and neck cancer

To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).

Authors: Ryo Toya, Tetsuo Saito, Kohsei Yamaguchi, Tomohiko Matsuyama, Takahiro Watakabe, Tadashi Matsumoto, Ryoji Yoshida, Akiyuki Hirosue, Daizo Murakami, Yorihisa Orita, Hideki Nakayama and Natsuo Oya