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  1. Current standard of treatment for newly diagnosed patients with glioblastoma (GBM) is surgical resection with adjuvant normofractionated radiotherapy (NFRT) combined with temozolomide (TMZ) chemotherapy. Hyper...

    Authors: Victor Lewitzki, Rainer J. Klement, Rebekka Kosmala, Dominik Lisowski, Michael Flentje and Bülent Polat

    Citation: Radiation Oncology 2019 14:227

    Content type: Research

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  2. To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-w...

    Authors: Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M. Ito, Nobuo Shinohara, Hiroki Shirato and Shinichi Shimizu

    Citation: Radiation Oncology 2019 14:226

    Content type: Research

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  3. The purpose of this study was to determine the associations between pathological complete remission (pCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) w...

    Authors: Kai Wang, Junlin Yi, Xiaodong Huang, Yuan Qu, Jingwei Luo, Jianping Xiao, Shiping Zhang, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Zhengang Xu, Shaoyan Liu and Xiaolei Wang

    Citation: Radiation Oncology 2019 14:225

    Content type: Research

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  4. To develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency a...

    Authors: Xiao Wang, Chi Ma, Rihan Davis, Rahul R. Parikh, Salma K. Jabbour, Bruce G. Haffty, Ning J. Yue, Ke Nie and Yin Zhang

    Citation: Radiation Oncology 2019 14:224

    Content type: Research

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  5. The addition of regional nodal radiation (RNI) to whole breast irradiation for high risk breast cancer improves metastases free survival and new data suggests it contributes additional benefit to overall survi...

    Authors: Chloe Pandeli, Lloyd M. L. Smyth, Steven David and Andrew W. See

    Citation: Radiation Oncology 2019 14:223

    Content type: Research

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  6. Mast Cell Activation Syndrome (MCAS) is classified as an idiopathic mast cell disorder where inconsistent or unknown triggers release inflammatory mediators and cause a constellation of symptoms. Studies demon...

    Authors: Robin E. Landy, William C. Stross, Jackson M. May, Tasneem A. Kaleem, Timothy D. Malouff, Mark R. Waddle and Laura A. Vallow

    Citation: Radiation Oncology 2019 14:222

    Content type: Case report

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  7. The aim of this study was to explore the relationships between dosimetric parameters of organs at risk and patient-reported outcomes (PRO) after radiotherapy of patients with head and neck cancer.

    Authors: Toyokazu Hayakawa, Shogo Kawakami, Itaru Soda, Takuro Kainuma, Marika Nozawa, Akane Sekiguchi, Shunsuke Miyamoto, Taku Yamashita and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:221

    Content type: Research

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  8. A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translatin...

    Authors: Slavisa Tubin, Martin Ashdown and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:220

    Content type: Short report

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  9. The microscopic tumor spread (MS) beyond the macroscopic tumor borders of esophageal tumors is crucial for determining the clinical target volume (CTV) in radiotherapy. The question arises whether current volu...

    Authors: Melanie Machiels, Maurits L. van Montfoort, Nikki B. Thuijs, Mark I. van Berge Henegouwen, Tanja Alderliesten, Sybren L. Meijer, Jeanin E. van Hooft and Maarten C. C. M. Hulshof

    Citation: Radiation Oncology 2019 14:219

    Content type: Research

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  10. In order to locate an arteriovenous malformation, typically, a digital subtraction angiography (DSA) is carried out. To use the DSA for target definition an accurate image registration between CT and DSA is re...

    Authors: Daniel Schmidhalter, Dominik Henzen, Evelyn Herrmann, Werner Volken, Paul-Henry Mackeprang, Ekin Ermis, Hossein Hemmatazad, Jonas Honegger, Benjamin Haas, Michael K. Fix and Peter Manser

    Citation: Radiation Oncology 2019 14:217

    Content type: Research

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  11. PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characte...

    Authors: Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti and Stefano Tomatis

    Citation: Radiation Oncology 2019 14:216

    Content type: Research

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  12. This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer.

    Authors: Jingwen Wang, Yun Guan, Weilie Gu, Senxiang Yan, Juying Zhou, Dan Huang, Tong Tong, Chao Li, Sanjun Cai, Zhen Zhang and Ji Zhu

    Citation: Radiation Oncology 2019 14:215

    Content type: Research

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  13. Treatment options for recurrent head and neck tumours in the previously irradiated area are limited, including re-irradiation due to radioresistance of the recurrent tumour and previous dose received by surrou...

    Authors: Vesna Todorovic, Ajda Prevc, Martina Niksic Zakelj, Monika Savarin, Andreja Brozic, Blaz Groselj, Primoz Strojan, Maja Cemazar and Gregor Sersa

    Citation: Radiation Oncology 2019 14:214

    Content type: Research

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  14. Accurate and standardized descriptions of organs at risk (OARs) are essential in radiation therapy for treatment planning and evaluation. Traditionally, physicians have contoured patient images manually, which...

    Authors: Sang Hee Ahn, Adam Unjin Yeo, Kwang Hyeon Kim, Chankyu Kim, Youngmoon Goh, Shinhaeng Cho, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Taeyoon Kim, Tae Hyun Kim, Sang Hee Youn, Eun Sang Oh and Jong Hwi Jeong

    Citation: Radiation Oncology 2019 14:213

    Content type: Research

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  15. Radiotherapy-induced lymphopenia may be limiting the success of therapy and could also negatively affect the ability of immune system in mediating the bystander (BE) and abscopal effects (AE). A novel SBRT-bas...

    Authors: Slavisa Tubin, Mohammad K. Khan, Gerardo Salerno, Waleed F. Mourad, Weisi Yan and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:212

    Content type: Methodology

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  16. To report dosimetry and early adverse effects, aesthetic, and patient-reported outcomes of a prospective study of 3-fraction pencil-beam scanning (PBS) proton accelerated partial irradiation (APBI).

    Authors: Robert W. Mutter, Krishan R. Jethwa, Karthik Gonuguntla, Nicholas B. Remmes, Thomas J. Whitaker, Tina J. Hieken, Kathryn J. Ruddy, Lisa A. McGee, Kimberly S. Corbin and Sean S. Park

    Citation: Radiation Oncology 2019 14:211

    Content type: Research

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  17. Small cell carcinoma of the esophagus (SCCE) is characterized by its progressive feature and poor prognosis. There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to charac...

    Authors: Baoqing Chen, Han Yang, Huali Ma, Qiaoqiao Li, Bo Qiu, Yonghong Hu and Yujia Zhu

    Citation: Radiation Oncology 2019 14:210

    Content type: Research

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  18. Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also be...

    Authors: Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki and Susumu Kanazawa

    Citation: Radiation Oncology 2019 14:209

    Content type: Research

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  19. Despite increasing clinical data suggest that internal mammary node (IMN) irradiation would improve local-regional control and overall survival in breast cancer, its role remains controversial due to increased...

    Authors: Yujie Wang, Weixiang Qi, Haoping Xu, Miao Zhang, Yimin Han, Jiayi Chen and Cheng Xu

    Citation: Radiation Oncology 2019 14:208

    Content type: Research

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  20. The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spa...

    Authors: Masayoshi Yamada, Hiraku Sato, Yoshiro Ieko, Yuya Miyasaka, Takayuki Kanai, Natsuko Yano, Takashi Ono, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Yasushi Teranishi, Yasuhiro Kikuchi and Kenji Nemoto

    Citation: Radiation Oncology 2019 14:207

    Content type: Research

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  21. To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiat...

    Authors: Xiyin Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, Lin Kong and Jiade J. Lu

    Citation: Radiation Oncology 2019 14:206

    Content type: Research

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  22. Some patients experience oligo-progression during androgen receptor targeted therapy (ARTT) treatments. This progression might not indicate a real systemic drug resistance, but a selective monoclonal resistanc...

    Authors: Maurizio Valeriani, Luca Marinelli, Serena Macrini, Chiara Reverberi, Anna Maria Aschelter, Vitaliana De Sanctis, Paolo Marchetti, Lidia Tronnolone and Mattia Falchetto Osti

    Citation: Radiation Oncology 2019 14:205

    Content type: Research

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  23. Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction can be detected early after BC RT with g...

    Authors: Valentin Walker, Olivier Lairez, Olivier Fondard, Atul Pathak, Baptiste Pinel, Christian Chevelle, Denis Franck, Gaëlle Jimenez, Jérémy Camilleri, Loïc Panh, David Broggio, Sylvie Derreumaux, Marie-Odile Bernier, Dominique Laurier, Jean Ferrières and Sophie Jacob

    Citation: Radiation Oncology 2019 14:204

    Content type: Research

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  24. To determine the prognostic effect of adjuvant radiation and clinicopathological variables in surgically treated patients with small cell carcinoma of the cervix (SCCC).

    Authors: Ting Shen, Yan-hui Jiang, Yao-yao Zou, Fang-fang Qiu, Xing-sheng Qiu and Kai-yun You

    Citation: Radiation Oncology 2019 14:203

    Content type: Research

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  25. The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment...

    Authors: Thomas Held, Paul Windisch, Sati Akbaba, Kristin Lang, Benjamin Farnia, Jakob Liermann, Denise Bernhardt, Peter Plinkert, Christian Freudlsperger, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg

    Citation: Radiation Oncology 2019 14:202

    Content type: Research

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  26. This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hF...

    Authors: Conti Alfredo, Senger Carolin, Acker Güliz, Kluge Anne, Pontoriero Antonio, Cacciola Alberto, Pergolizzi Stefano, Germanò Antonino, Badakhshi Harun, Kufeld Markus, Meinert Franziska, Nguyen Phuong, Loebel Franziska, Vajkoczy Peter, Budach Volker and Kaul David

    Citation: Radiation Oncology 2019 14:201

    Content type: Research

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  27. The purpose of this study was to evaluate the outcomes of elderly patients (aged ≥75 years) with newly diagnosed glioblastoma (GBM), who were treated with hypofractionated radiotherapy comprising 45 Gy in 15 f...

    Authors: Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura and Yoshitaka Narita

    Citation: Radiation Oncology 2019 14:200

    Content type: Research

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  28. Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this stu...

    Authors: Steffen Auerswald, Stephan Schreml, Robert Meier, Alexandra Blancke Soares, Maximilian Niyazi, Sebastian Marschner, Claus Belka, Martin Canis and Frank Haubner

    Citation: Radiation Oncology 2019 14:199

    Content type: Research

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  29. Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...

    Authors: Marco M. E. Vogel, Kerstin A. Kessel, Kilian Schiller, Michal Devecka, Jürgen E. Gschwend, Wilko Weichert, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:198

    Content type: Research

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  30. The appropriate timing of radiotherapy (RT) for patients after radical prostatectomy (RP) with adverse pathological features (APFs) remains controversial. This systematic review was conducted to compare the ef...

    Authors: Ronggui Tao, Jindong Dai, Yunjin Bai, Jiyu Yang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Hao Zeng and Pengfei Shen

    Citation: Radiation Oncology 2019 14:197

    Content type: Review

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  31. To compare irradiation dose to the second and third portions of duodenum (Duo2 and Duo3) with a new refined and old delineation method of para-aortic region for patients with locally advanced cervical cancer (...

    Authors: Bo Yang, Xiaoliang Liu, Ke Hu, Jie Qiu, Fuquan Zhang, Xiaorong Hou, Junfang Yan, Qingyu Meng, Weiping Wang, Lang Yu and Yijun Wang

    Citation: Radiation Oncology 2019 14:196

    Content type: Research

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  32. The optimal treatment for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains inconclusive. Previous studies have shown that stereotactic body radiotherapy (SBRT) provides encouraging ...

    Authors: Baiqiang Dong, Jin Wang, Xuan Zhu, Yuanyuan Chen, Yujin Xu, Kainan Shao, Lei Zheng, Hangjie Ying, Ming Chen and Jianping Cao

    Citation: Radiation Oncology 2019 14:195

    Content type: Research

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  33. Stereotactic body radiation therapy (SBRT) was found effective in treating laryngeal cancer with only five treatment fractions by a recent clinical trial (NCT01984502, ClinicalTrials.gov). Nevertheless, this t...

    Authors: You Zhang, Tsuicheng Chiu, Jeffrey Dubas, Zhen Tian, Pam Lee, Xuejun Gu, Yulong Yan, David Sher, Robert Timmerman and Bo Zhao

    Citation: Radiation Oncology 2019 14:193

    Content type: Research

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  34. To determine the biological correlation between apparent diffusion coefficient (ADC) values and Sirtuin1 (SIRT1) levels of tumour tissues in patients with esophageal carcinoma (EC), and to ascertain the treatm...

    Authors: Ying Chen, Tieming Xie, Zhimin Ye, Fangzheng Wang, Dan Long, Mingxiang Jiang, Jun Fang, Qingren Lin, Kai Li, Zhun Wang and Zhenfu Fu

    Citation: Radiation Oncology 2019 14:192

    Content type: Research

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  35. Re-irradiation (re-RT) has the active effect of relieving clinical symptoms and prolonging the survival of patients with recurrent esophageal squamous cell carcinoma (ESCC). However, the optimal re-RT dose is ...

    Authors: Xiujuan Xu, Zhongming Wang, Shunian Jiang, Yuping Shang and Yan Wu

    Citation: Radiation Oncology 2019 14:191

    Content type: Research

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  36. We aimed to ascertain population-based practice patterns and survival outcomes of postoperative radiotherapy following breast conserving-surgery (BCS) in elderly women (aged ≥65 years) with early-stage pure mu...

    Authors: San-Gang Wu, Feng-Yan Li, Jun Wang, Chen-Lu Lian, Juan Zhou and Zhen-Yu He

    Citation: Radiation Oncology 2019 14:190

    Content type: Research

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  37. Patients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prom...

    Authors: Louise Belshaw, Christina E. Agnew, Denise M. Irvine, Keith P. Rooney and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:189

    Content type: Research

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  38. Thoracic and head and neck cancer radiation therapy (RT) can cause damage to nearby healthy organs such as the esophagus, causing acute radiation-induced esophageal damage (ARIED). A non-invasive method to det...

    Authors: Pouya Jelvehgaran, Jeffrey D. Steinberg, Artem Khmelinskii, Gerben Borst, Ji-Ying Song, Niels de Wit, Daniel M. de Bruin and Marcel van Herk

    Citation: Radiation Oncology 2019 14:188

    Content type: Research

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  39. To determine if the performance of a knowledge based RapidPlan (RP) planning model could be improved with an iterative learning process, i.e. if plans generated by an RP model could be used as new input to re-...

    Authors: A. Fogliata, L. Cozzi, G. Reggiori, A. Stravato, F. Lobefalo, C. Franzese, D. Franceschini, S. Tomatis and M. Scorsetti

    Citation: Radiation Oncology 2019 14:187

    Content type: Research

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  40. Tumor motion may compromise the accuracy of liver stereotactic radiotherapy. In order to carry out a precise planning, estimating liver tumor motion during radiotherapy has received a lot of attention. Previou...

    Authors: Wu-zhou Li, Zhi-wen Liang, Yi Cao, Ting-ting Cao, Hong Quan, Zhi-yong Yang, Qin Li and Zhi-tao Dai

    Citation: Radiation Oncology 2019 14:185

    Content type: Research

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  41. Stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) are well established local treatment approaches in several cancer settings. Although SBRT is still under investigation for spinal metas...

    Authors: Niccolò Giaj-Levra, Maximilian Niyazi, Vanessa Figlia, Giuseppe Napoli, Rosario Mazzola, Luca Nicosia, Stefanie Corradini, Ruggero Ruggieri, Giuseppe Minniti and Filippo Alongi

    Citation: Radiation Oncology 2019 14:184

    Content type: Research

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  42. To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects.

    Authors: Kilian-Simon Baumann, Veronika Flatten, Uli Weber, Stefan Lautenschläger, Fabian Eberle, Klemens Zink and Rita Engenhart-Cabillic

    Citation: Radiation Oncology 2019 14:183

    Content type: Research

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  43. Patients with N3 stage nasopharyngeal carcinoma (NPC) are at high risk for treatment failure. This study aims to assess the efficacy of maintenance chemotherapy (MC) using S-1 (MC-S1), a novel oral fluoropyrim...

    Authors: Jingfeng Zong, Hanchuan Xu, Bijuan Chen, Qiaojuan Guo, Yun Xu, Chuanben Chen, Youliang Weng, Wei Zheng, Jianji Pan and Shaojun Lin

    Citation: Radiation Oncology 2019 14:182

    Content type: Research

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  44. We aimed to identify the risk factors and provide a nomogram for the prediction of radiotherapy-related esophageal fistula in patients with esophageal cancer (EC) using a case-control study.

    Authors: Yiyue Xu, Linlin Wang, Bo He, Wanlong Li, Qiang Wen, Shijiang Wang, Xindong Sun, Xue Meng and Jinming Yu

    Citation: Radiation Oncology 2019 14:181

    Content type: Research

    Published on:

  45. This study aimed to compare the clinical outcomes of stereotactic ablative radiotherapy (SABR) and conventionally fractionated radiotherapy (CFRT) in hepatocellular carcinoma (HCC) patients with portal vein in...

    Authors: Jen-Fu Yang, Cheng-Hsiang Lo, Meei-Shyuan Lee, Chun-Shu Lin, Yang-Hong Dai, Po-Chien Shen, Hsing-Lung Chao and Wen-Yen Huang

    Citation: Radiation Oncology 2019 14:180

    Content type: Research

    Published on:

  46. To assess late toxicity, quality of life and oncological outcome after consolidative whole abdominal radiotherapy (WART) following cytoreductive surgery and carboplatin/paclitaxel chemotherapy in high risk pat...

    Authors: Nathalie Arians, Meinhard Kieser, Laura Benner, Nathalie Rochet, Lars Schröder, Sonja Katayama, Klaus Herfarth, Kai Schubert, Andreas Schneeweiss, Christof Sohn, Katja Lindel and Jürgen Debus

    Citation: Radiation Oncology 2019 14:179

    Content type: Research

    Published on:

  47. Radiation Therapy Oncology Group (RTOG) 94–05 has demonstrated that higher dose radiation didn’t improve outcome of patients with esophageal cancer (EC). However, several retrospective studies showed that a hi...

    Authors: He-San Luo, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:178

    Content type: Review

    Published on:

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