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Radiation Oncology


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  1. Content type: Research

    The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

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  2. Content type: Research

    We evaluated dynamic changes in 18F–borono-L-phenylalanine (18F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neut...

    Authors: Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai and Jun Itami

    Citation: Radiation Oncology 2018 13:4

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  3. Content type: Research

    Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melano...

    Authors: Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck and David Kaul

    Citation: Radiation Oncology 2018 13:3

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  4. Content type: Research

    Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico ...

    Authors: Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus and Katia Parodi

    Citation: Radiation Oncology 2018 13:2

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  5. Content type: Research

    Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhi...

    Authors: Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E. Lipson, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2018 13:1

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  6. Content type: Research

    Tumor Treating Fields (TTFields) are an anti-neoplastic treatment modality delivered via application of alternating electric fields using insulated transducer arrays placed directly on the skin in the region s...

    Authors: Moshe Giladi, Mijal Munster, Rosa S. Schneiderman, Tali Voloshin, Yaara Porat, Roni Blat, Katarzyna Zielinska-Chomej, Petra Hååg, Ze’ev Bomzon, Eilon D. Kirson, Uri Weinberg, Kristina Viktorsson, Rolf Lewensohn and Yoram Palti

    Citation: Radiation Oncology 2017 12:206

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  7. Content type: Research

    Postoperative radiation (PORT) is an option for non-small cell lung cancer (NSCLC) patients with resectable stage IIIA pathological N2 status (pN2). For patients with PORT, this study aims to investigate the i...

    Authors: Siwei Wang, Zhifei Ma, Xiangbao Yang, Yajing Wang, Youtao Xu, Wenjia Xia, Rui Chen, Mantang Qiu, Feng Jiang, Rong Yin, Lin Xu and Keping Xu

    Citation: Radiation Oncology 2017 12:207

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  8. Content type: Research

    Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibi...

    Authors: Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2017 12:208

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  9. Content type: Research

    Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. These small animal radioth...

    Authors: Mihaela Ghita, Stephen J. McMahon, Hannah F. Thompson, Conor K. McGarry, Raymond King, Sarah O. S. Osman, Jonathan L. Kane, Amanda Tulk, Giuseppe Schettino, Karl T. Butterworth, Alan R. Hounsell and Kevin M. Prise

    Citation: Radiation Oncology 2017 12:204

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  10. Content type: Review

    Pancreatic cancer, especially in case of locally advanced stage has a poor prognosis. Radiotherapy in general can lead to tumor volume reduction, but further improvements, such as ion beam therapy have to be p...

    Authors: Constantin Dreher, Daniel Habermehl, Oliver Jäkel and Stephanie E. Combs

    Citation: Radiation Oncology 2017 12:203

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  11. Content type: Research

    Cisplatin and gemcitabine combined with conventional radiation therapy in the treatment of cervical cancer patients results in a favorable outcome but with excess toxicity. The purpose of this study was to eva...

    Authors: Nikola Cihoric, Alexandros Tsikkinis, Eugenia Vlaskou Badra, Markus Glatzer, Urban Novak, Amina Scherz, Mohamed Shelan, Ivan Soldatovic, Chittazhathu Kurian Kuruvilla Yojena, Daniel M. Aebersold and Kristina Lössl

    Citation: Radiation Oncology 2017 12:202

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  12. Content type: Research

    Our previous studies showed that vasoconstrictor applied topically to rat skin minutes before irradiation completely prevented radiodermatitis. Here we report on a Phase IIa study of topically applied NG12-1 v...

    Authors: James F. Cleary, Bethany M. Anderson, Jens C. Eickhoff, Deepak Khuntia and William E. Fahl

    Citation: Radiation Oncology 2017 12:201

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  13. Content type: Review

    The aim of this review is the critical appraisal of the current use of volumetric modulated arc therapy for the radiation therapy management of breast cancer. Both clinical and treatment planning studies were ...

    Authors: Luca Cozzi, Frank Lohr, Antonella Fogliata, Davide Franceschini, Fiorenza De Rose, A R Filippi, Gabriele Guidi, Valentina Vanoni and Marta Scorsetti

    Citation: Radiation Oncology 2017 12:200

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  14. Content type: Research

    The internal mammary (IM) lymph node chain, along with the axillary nodal basin, is a first-echelon breast lymphatic draining site. A growing body of evidence supports irradiation of this region in node-positi...

    Authors: Sean Sachdev, Chelain R. Goodman, Erin Neuschler, Kapila Kalakota, Daniel Cutright, Eric D. Donnelly, John P. Hayes, Adam E. Prescott, Gianna Mirabelli and Jonathan B. Strauss

    Citation: Radiation Oncology 2017 12:199

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  15. Content type: Research

    Peri-operative radiation of retroperitoneal sarcomas (RPS) is an important component of multidisciplinary treatment. All retrospective series thus far included patients treated with older radiation therapy (RT...

    Authors: Pippa F. Cosper, Jeffrey Olsen, Todd DeWees, Brian A. Van Tine, William Hawkins, Jeff Michalski and Imran Zoberi

    Citation: Radiation Oncology 2017 12:198

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  16. Content type: Research

    The optimization of the management for elderly glioblastoma patients is crucial given the demographics of aging in many countries. We report the outcomes for a “real-life” patient cohort (i.e. unselected) comp...

    Authors: J. Biau, E. Chautard, E. De Schlichting, G. Dupic, B. Pereira, A. Fogli, M. Müller-Barthélémy, P. Dalloz, T. Khalil, A. F. Dillies, X. Durando, C. Godfraind and P. Verrelle

    Citation: Radiation Oncology 2017 12:197

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  17. Content type: Research

    To compare organ-at-risk doses and setup reproducibility using the prone and supine orientations in volumetric modulated arc therapy (VMAT) for rectal cancer.

    Authors: Anthony Kim, Aliaksandr Karotki, Joe Presutti, Glen Gonzales, Shun Wong and William Chu

    Citation: Radiation Oncology 2017 12:180

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  18. Content type: Research

    To evaluate the role of radiotherapy (RT) as an adjuvant or definitive treatment in primary tracheal adenoid cystic carcinoma (ACC) for local tumor control and survival.

    Authors: Hyoung Uk Je, Si Yeol Song, Dong Kwan Kim, Yong-Hee Kim, Seong-Yun Jeong, Geum Mun Back, Wonsik Choi, Su Ssan Kim, Seung-Il Park and Eun Kyung Choi

    Citation: Radiation Oncology 2017 12:196

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  19. Content type: Research

    Heath-related quality of life (HRQoL) among survivors with unresectable locally-advanced non-small cell lung cancer (LA-NSCLC) treated with radiotherapy and chemotherapy still is not clear. The current study w...

    Authors: Juntao Ran, Jingbo Wang, Nan Bi, Wei Jiang, Zongmei Zhou, Zhouguang Hui, Jun Liang, Qinfu Feng and Luhua Wang

    Citation: Radiation Oncology 2017 12:195

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  20. Content type: Research

    To investigate radiation oncologists’ opinions on important considerations to offering re-irradiation (re-RT) as a treatment option for recurrent glioma.

    Authors: Andra V. Krauze, Albert Attia, Steve Braunstein, Michael Chan, Stephanie E. Combs, Rainer Fietkau, John Fiveash, John Flickinger, Anca Grosu, Steven Howard, Carsten Nieder, Maximilian Niyazi, Lindsay Rowe, Dee Dee Smart, Christina Tsien and Kevin Camphausen

    Citation: Radiation Oncology 2017 12:194

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  21. Content type: Research

    The purpose of this study was to investigate the differences in the dosimetric advantage of using intraoperatively built custom-linked (IBCL) seeds between permanent iodine-125 (I-125) seed implantation (PI) a...

    Authors: Katsumi Hirose, Masahiko Aoki, Mariko Sato, Hiroyoshi Akimoto, Yasuhiro Hashimoto, Atsushi Imai, Noritaka Kamimura, Hideo Kawaguchi, Yoshiomi Hatayama, Ichitaro Fujioka, Mitsuki Tanaka, Chikara Ohyama and Yoshihiro Takai

    Citation: Radiation Oncology 2017 12:192

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  22. Content type: Review

    The rapid rise of particle therapy across the world necessitates evidence to justify its ever-increasing utilization. This narrative review summarizes the current status of these technologies on treatment of b...

    Authors: Sebastian Adeberg, Semi B. Harrabi, Vivek Verma, Denise Bernhardt, Nicole Grau, Jürgen Debus and Stefan Rieken

    Citation: Radiation Oncology 2017 12:193

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  23. Content type: Research

    Despite mounting evidence for the use of re-irradiation (re-RT) in recurrent high grade glioma, optimal patient selection criteria for re-RT remain unknown. We present a novel scoring system based on radiobiol...

    Authors: Andra Valentina Krauze, Cord Peters, Jason Cheng, Holly Ning, Megan Mackey, Lindsay Rowe, Theresa Cooley-Zgela, Dee Dee Smart and Kevin Camphausen

    Citation: Radiation Oncology 2017 12:191

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  24. Content type: Study protocol

    The prognosis for patients with cervical or endometrial cancer has improved over the last decades. Thus, reducing therapy-related toxicity and impact on quality of life have become more and more important. Wit...

    Authors: N. Arians, K. Lindel, J. Krisam, K. Herfarth, D. Krug, S. Akbaba, J. Oelmann-Avendano and J. Debus

    Citation: Radiation Oncology 2017 12:188

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