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  1. The COVID-19 pandemic has stripped many medical students worldwide of their right to quality education. In response, we developed hybrid courses involving aspects of both online and in-person teaching for radi...

    Authors: Tae Hyung Kim, Jin Sung Kim, Hong In Yoon, Joongyo Lee, Jason Joon Bock Lee, Hwa Kyung Byun, Yeona Cho, Yong Bae Kim, Ik Jae Lee, Kyung Hwan Kim and Jee Suk Chang

    Citation: Radiation Oncology 2021 16:204

    Content type: Research

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  2. To study the performance of a proposed deep learning-based autocontouring system in delineating organs at risk (OARs) in breast radiotherapy with a group of experts.

    Authors: Hwa Kyung Byun, Jee Suk Chang, Min Seo Choi, Jaehee Chun, Jinhong Jung, Chiyoung Jeong, Jin Sung Kim, Yongjin Chang, Seung Yeun Chung, Seungryul Lee and Yong Bae Kim

    Citation: Radiation Oncology 2021 16:203

    Content type: Research

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  3. To develop high-quality synthetic CT (sCT) generation method from low-dose cone-beam CT (CBCT) images by using attention-guided generative adversarial networks (AGGAN) and apply these images to dose calculatio...

    Authors: Liugang Gao, Kai Xie, Xiaojin Wu, Zhengda Lu, Chunying Li, Jiawei Sun, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2021 16:202

    Content type: Research

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  4. To develop a nomogram model for predicting local progress-free survival (LPFS) in esophageal squamous cell carcinoma (ESCC) patients treated with concurrent chemo-radiotherapy (CCRT).

    Authors: He-San Luo, Ying-Ying Chen, Wei-Zhen Huang, Sheng-Xi Wu, Shao-Fu Huang, Hong-Yao Xu, Ren-Liang Xue, Ze-Sen Du, Xu-Yuan Li, Lian-Xin Lin and He-Cheng Huang

    Citation: Radiation Oncology 2021 16:201

    Content type: Research

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  5. Hypoxia is known to be prevalent in solid tumors such as non-small cell lung cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET imaging can provide in-vivo hypoxia measurements...

    Authors: Andreas Köthe, Nicola Bizzocchi, Sairos Safai, Antony John Lomax, Damien Charles Weber and Giovanni Fattori

    Citation: Radiation Oncology 2021 16:199

    Content type: Research

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  6. Second head and neck neuroendocrine carcinoma (NEC) after radical radiotherapy for nasopharyngeal carcinoma (NPC) treatment is rarely reported. The prognosis of second cancer is poor, and our research focuses ...

    Authors: Ying-peng Peng, Qiao-dan Liu, Yu-jing Lin, Shun-li Peng, Rong Wang, Xi-wei Xu, Wei Wei, Gui-hua Zhong, Yu-ling Zhou, Ya-qin Zhang, Ye Liu, Si-yang Wang, Hai-yu Hong and Zhi-gang Liu

    Citation: Radiation Oncology 2021 16:198

    Content type: Research

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  7. Approximately one third of cancer patients will develop spinal metastases, that can be associated with back pain, neurological symptoms and deterioration in performance status. Stereotactic radiosurgery (SRS) ...

    Authors: Niccolò Giaj-Levra, Vanessa Figlia, Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attinà, Claudio Vitale, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Filippo Alongi

    Citation: Radiation Oncology 2021 16:197

    Content type: Research

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  8. Adjuvant therapy is a promising treatment to improve the prognosis of cancer patients, however, the evidence base driving recommendations for adjuvant radiotherapy (ART) or chemotherapy (ACT) in retroperitonea...

    Authors: Xiangji Li, Tong Wu, Mengmeng Xiao, Shanshan Wu, Li Min and Chenghua Luo

    Citation: Radiation Oncology 2021 16:196

    Content type: Research

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  9. Whether adjuvant chemotherapy (AC) after concurrent chemoradiotherapy (CCRT) could provide benefit to esophageal squamous cell carcinoma (ESCC) patients is controversial. Therefore, we decided to investigate t...

    Authors: Ao Liu, Yalin Wang, Xin Wang, Liqiong Zhu, Yu Nie and Minghuan Li

    Citation: Radiation Oncology 2021 16:195

    Content type: Research

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  10. Systemic response to local anticancer treatment is a phenomenon called ‘abscopal effect’. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, parti...

    Authors: Oliver Vilinovszki, Nicolaus Andratschke, Martin Huellner, Alessandra Curioni-Fontecedro and Stephanie G. C. Kroeze

    Citation: Radiation Oncology 2021 16:194

    Content type: Case report

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  11. Stereotactic body radiotherapy (SBRT) is increasingly used for treatment of liver tumors but the effect on metabolic liver function in surrounding tissue is largely unknown. Using 2-deoxy-2-[18F]fluoro-d-galactos...

    Authors: Michael Sørensen, Mette Marie Fode, Jørgen Baltzer Petersen, Marianne Ingerslev Holt and Morten Høyer

    Citation: Radiation Oncology 2021 16:192

    Content type: Research

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  12. To determine the most appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with maxillary sinus cancer (MSC).

    Authors: Yasuo Kosugi, Michimasa Suzuki, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Yoichi Muramoto, Terufumi Kawamoto, Masaki Oshima, Naoto Shikama and Keisuke Sasai

    Citation: Radiation Oncology 2021 16:190

    Content type: Research

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  13. MR-guided online adaptive stereotactic body radiation therapy (SBRT) for prostate cancer aims to reduce toxicity by full compensation of interfractional uncertainties. However, the process of online adaptation...

    Authors: J. Schaule, M. Chamberlain, L. Wilke, M. Baumgartl, J. Krayenbühl, M. Zamburlini, M. Mayinger, N. Andratschke, S. Tanadini-Lang and M. Guckenberger

    Citation: Radiation Oncology 2021 16:189

    Content type: Research

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  14. In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potenti...

    Authors: Duncan den Boer, Johannes K. Veldman, Geertjan van Tienhoven, Arjan Bel and Zdenko van Kesteren

    Citation: Radiation Oncology 2021 16:188

    Content type: Research

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  15. Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radia...

    Authors: Lina Wang, Xiaohu Wang, Guangwen Zhang, Yan Ma, Qiuning Zhang, Zheng Li, Juntao Ran, Xiaoming Hou, Yichao Geng, Zheng Yang, Shuangwu Feng, Chengcheng Li and Xueshan Zhao

    Citation: Radiation Oncology 2021 16:187

    Content type: Review

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  16. To develop a risk model based on dosimetric metrics to predict local recurrence in nasopharyngeal carcinoma (NPC) patients treated with intensive modulated radiation therapy (IMRT).

    Authors: Wenjun Liao, Jinlan He, Zijian Liu, Maolang Tian, Jiangping Yang, Jiaqi Han and Jianghong Xiao

    Citation: Radiation Oncology 2021 16:186

    Content type: Research

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  17. To investigate the relationship between radiotherapy (RT) and the risk of cerebrovascular mortality (CVM) in head and neck cancer (HNC) survivors aged ≥ 65 years.

    Authors: Qing-Song He, Zhen-Ping Wang, Zhao-Jun Li, Ping Zhou, Chen-Lu Lian, San-Gang Wu and Si-Fang Chen

    Citation: Radiation Oncology 2021 16:185

    Content type: Research

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  18. The role of postoperative radiotherapy (PORT) in cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected non-small cell lung cancer (NSCLC) remains uncertain. The purpose of this pop...

    Authors: Xia Wang, Jiaqi Song, Jie Long, Zhimin Zeng and Anwen Liu

    Citation: Radiation Oncology 2021 16:184

    Content type: Research

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  19. Hybrid magnetic resonance (MR)-guided linear accelerators represent a new horizon in the field of radiation oncology. By harnessing the favorable combination of on-board MR-imaging with the possibility to dail...

    Authors: Francesco Cuccia, Filippo Alongi, Claus Belka, Luca Boldrini, Juliane Hörner-Rieber, Helen McNair, Michele Rigo, Maartje Schoenmakers, Maximilian Niyazi, Judith Slagter, Claudio Votta and Stefanie Corradini

    Citation: Radiation Oncology 2021 16:183

    Content type: Review

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  20. We aimed to assess the feasibility of a dose painting (DP) procedure, known as simultaneous integrated boost intensity modulated radiation Therapy (SIB-IMRT), for treating prostate cancer with dominant intrapr...

    Authors: Seyed Masoud Rezaeijo, Bijan Hashemi, Bahram Mofid, Mohsen Bakhshandeh, Arash Mahdavi and Mohammad Saber Hashemi

    Citation: Radiation Oncology 2021 16:182

    Content type: Research

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  21. In patients with stage III melanoma, the use of adjuvant radiation therapy (RT) after lymph node dissection (LND) may be currently considered in selected high-risk patients to improve tumor control. Melanomas ...

    Authors: Adam R. Wolfe, Priyanka Chablani, Michael R. Siedow, Eric D. Miller, Steve Walston, Kari L. Kendra, Evan Wuthrick and Terence M. Williams

    Citation: Radiation Oncology 2021 16:181

    Content type: Research

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  22. To report preliminary data on treatment outcome and compliance to dose-intensified organ sparing SBRT for prostate cancer using a novel electromagnetic transmitter-based tracking system (RayPilot® System) to a...

    Authors: Raffaella Lucchini, Denis Panizza, Riccardo Ray Colciago, Veronica Vernier, Martina Camilla Daniotti, Valeria Faccenda and Stefano Arcangeli

    Citation: Radiation Oncology 2021 16:180

    Content type: Research

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  23. The purpose of the study was to assess the uterus motions and bladder volume changes of fractional movements in cervical sites throughout the external beam radiotherapy (EBRT) treatment.

    Authors: Xu Li, Lizhen Wang, Zhen Cui, Yukun Li, Pei Liu, Yungang Wang, Jinhong Zhu, Jianmin Zhu, Yong Yin and Zhenjiang Li

    Citation: Radiation Oncology 2021 16:179

    Content type: Research

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    The Correction to this article has been published in Radiation Oncology 2021 16:200

  24. There is limited evidence concerning radiotherapy for painful lymph node metastases (PLM). We evaluated the effectiveness of radiotherapy for PLM using the International Consensus Endpoint in a subgroup analys...

    Authors: Kohsei Yamaguchi, Tetsuo Saito, Ryo Toya, Etsushi Tomitaka, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takahiro Watakabe, Hirohito Otsuka and Natsuo Oya

    Citation: Radiation Oncology 2021 16:178

    Content type: Research

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  25. The SWORD trial is the first multicenter, single arm, phase II study assessing the safety and efficacy of a PD-1 inhibitor (Sintilimab), stereotactic body radiotherapy (SBRT) and granulocyte–macrophage colony ...

    Authors: Jianjiao Ni, Yue Zhou, Lin Wu, Xinghao Ai, Xiaorong Dong, Qian Chu, Chengbo Han, Xiaofei Wang and Zhengfei Zhu

    Citation: Radiation Oncology 2021 16:177

    Content type: Research

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  26. The aim of this study was to compare the pattern of intra-patient spread of lymph-node (LN)-metastases within the mediastinum as assessed by 18F-FDG PET/CT and systematic endobronchial ultrasound-guided transbron...

    Authors: Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Christoph Pöttgen, Nika Guberina, Thomas Gauler, Till Ploenes, Lale Umutlu, Dirk Theegarten, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Metzenmacher, Marcel Wiesweg, Rüdiger Karpf-Wissel, Martin Schuler, Ken Herrmann…

    Citation: Radiation Oncology 2021 16:176

    Content type: Research

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  27. Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been a critical issue in this process. An atlas-based automatic segmentation w...

    Authors: Yuka Urago, Hiroyuki Okamoto, Tomoya Kaneda, Naoya Murakami, Tairo Kashihara, Mihiro Takemori, Hiroki Nakayama, Kotaro Iijima, Takahito Chiba, Junichi Kuwahara, Shouichi Katsuta, Satoshi Nakamura, Weishan Chang, Hidetoshi Saitoh and Hiroshi Igaki

    Citation: Radiation Oncology 2021 16:175

    Content type: Research

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  28. Proton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general, includes placing radiopaque clips to ensure exact eye-positioning during r...

    Authors: Johannes Gollrad, Christopher Rabsahl, Aline-Isabel Riechardt, Jens Heufelder, Andrea Stroux, Ute Goerling, Antonia Joussen, Volker Budach and Dirk Boehmer

    Citation: Radiation Oncology 2021 16:174

    Content type: Research

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  29. This study aimed to investigate the effect of abdominal compression on tumour motion and target volume and to determine suitable planning target volume (PTV) margins for patients treated with lung stereotactic...

    Authors: Yuanjun Qi, Jianbin Li, Yingjie Zhang, Qian Shao, Xijun Liu, Fengxiang Li, Jinzhi Wang, Zhenxiang Li and Wei Wang

    Citation: Radiation Oncology 2021 16:173

    Content type: Research

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  30. To investigate risk factors for developing radiation-associated facial lymphedema (FL) in nasopharyngeal carcinoma (NPC) patients after concurrent chemoradiation (CCRT).

    Authors: Donghyun Kim, Jiho Nam, Wontaek Kim, Dahl Park, Jihyeon Joo, Hosang Jeon and Yongkan Ki

    Citation: Radiation Oncology 2021 16:172

    Content type: Research

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  31. To compare the dosimetric, normal tissue complication probability (NTCP), secondary cancer complication probabilities (SCCP), and excess absolute risk (EAR) differences of volumetric modulated arc therapy (VMA...

    Authors: Yun Zhang, Yuling Huang, Shenggou Ding, Xingxing Yuan, Yuxian Shu, Jinhui Liang, Qingfeng Mao, Chunling Jiang and Jingao Li

    Citation: Radiation Oncology 2021 16:171

    Content type: Research

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  32. Stereotactic Body Radiotherapy (SBRT) has shown effectiveness in treating bone metastases to alleviate pain. The benefit of SBRT may be further harnessed especially when radiating disease from primary malignan...

    Authors: Eric K. Nguyen, Kimmen Quan, Sameer Parpia, Stephan Tran and Anand Swaminath

    Citation: Radiation Oncology 2021 16:170

    Content type: Study protocol

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  33. To evaluate the combined effect of rotational error and dose gradient on target dose coverage in frameless stereotactic radiotherapy.

    Authors: Jai-Woong Yoon, Soah Park, Kwang-Ho Cheong, Sei-Kwon Kang and Tae Jin Han

    Citation: Radiation Oncology 2021 16:169

    Content type: Research

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  34. The objective of this study was to analyze the amplitude of translational and rotational movements occurring during stereotactic body radiotherapy (SBRT) of spinal metastases in two different positioning devic...

    Authors: Ahmed Hadj Henni, David Gensanne, Maximilien Roge, Chantal Hanzen, Guillaume Bulot, Elyse Colard and Sebastien Thureau

    Citation: Radiation Oncology 2021 16:168

    Content type: Research

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  35. To evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).

    Authors: Zhigong Wei, Xingchen Peng, Yan Wang, Lianlian Yang, Ling He, Zheran Liu, Jingjing Wang, Xiaoli Mu, Ruidan Li and Jianghong Xiao

    Citation: Radiation Oncology 2021 16:167

    Content type: Research

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  36. Most anterior visual pathway meningiomas (AVPM) are benign and slow-growing, but these tumors may affect visual functions, including visual acuity (VA) and visual field (VF). Due to location, most are treated ...

    Authors: Leor Zach, Amir Agami, Orit Furman, Moshe Attia, Zvi Cohen, Iris Ben-Bassat Mizrachi, Guy Tam, Zion Zibly, Ouzi Nissim, Roberto Spiegelmann and Ruth Huna-Baron

    Citation: Radiation Oncology 2021 16:166

    Content type: Research

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  37. Multifocal manifestation of high-grade glioma is a rare disease with very unfavourable prognosis. The pathogenesis of multifocal glioma and pathophysiological differences to unifocal glioma are not fully under...

    Authors: Daniel Felix Fleischmann, Rudolph Schön, Stefanie Corradini, Raphael Bodensohn, Indrawati Hadi, Jan Hofmaier, Robert Forbrig, Niklas Thon, Mario Dorostkar, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2021 16:165

    Content type: Research

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  38. The benefit and the risk profile of Gamma Knife radiosurgery (GKRS) for intracerebral cavernoma remains incompletely defined in part due to the natural history of low incidence of bleeding and spontaneous regr...

    Authors: Chiung-Chyi Shen, Ming Hsi Sun, Meng-Yin Yang, Weir-Chiang You, Meei-Ling Sheu, Yen-Ju Chen, Ying Ju Chen, Jason Sheehan and Hung-Chuan Pan

    Citation: Radiation Oncology 2021 16:164

    Content type: Research

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  39. Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel...

    Authors: Catherine R. Hanna, Sean M. O’Cathail, Janet S. Graham, Mark Saunders, Leslie Samuel, Mark Harrison, Lynsey Devlin, Joanne Edwards, Daniel R. Gaya, Caroline A. Kelly, Liz-Anne Lewsley, Noori Maka, Paula Morrison, Louise Dinnett, Susan Dillon, Jacqueline Gourlay…

    Citation: Radiation Oncology 2021 16:163

    Content type: Study protocol

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  40. Authors: Heather Miller, Koji Matsuo, Lynda D. Roman, Annie A. Yessaian, Huyen Q. Pham, Marianne Hom, Antonio Castaneda, Anthony Pham, Omar Ragab, Laila Muderspach, Marcia Ciccone and Laurie L. Brunette

    Citation: Radiation Oncology 2021 16:162

    Content type: Correction

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    The original article was published in Radiation Oncology 2021 16:123

  41. Gastric bleeding negatively impacts the quality of life of patients with unresectable advanced gastric cancer and is frequently lethal. We investigated the efficacy of RT for palliation of gastric bleeding fro...

    Authors: Joongyo Lee, Hwa Kyung Byun, Woong Sub Koom, Yong Chan Lee and Jinsil Seong

    Citation: Radiation Oncology 2021 16:161

    Content type: Research

    Published on:

  42. Disruption of the tumor-brain barrier in meningioma is a crucial factor in peritumoral brain edema (PTBE). We previously reported the possible effect of osteoporosis on the integrity of the arachnoid trabecula...

    Authors: Sang Mook Kang, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Young Soo Kim and Myung-Hoon Han

    Citation: Radiation Oncology 2021 16:160

    Content type: Research

    Published on:

  43. Invasiveness is a major factor contributing to metastasis of tumour cells. Given the broad variety and plasticity of invasion mechanisms, assessing potential metastasis-promoting effects of irradiation for spe...

    Authors: Jia Mei, Claudia Böhland, Anika Geiger, Iris Baur, Kristina Berner, Steffen Heuer, Xue Liu, Laura Mataite, M. Camila Melo-Narváez, Erdem Özkaya, Anna Rupp, Christian Siebenwirth, Felix Thoma, Matthias F. Kling and Anna A. Friedl

    Citation: Radiation Oncology 2021 16:159

    Content type: Research

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  44. To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

    Authors: Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu, Yanhua Duan, Aihui Feng and Zhiyong Xu

    Citation: Radiation Oncology 2021 16:158

    Content type: Research

    Published on:

  45. Patients with low-grade gliomas (LGGs) harboring O6-methylguanine-DNA methyltransferase promoter nonmethylation (MGMT-non-pM) have a particularly short survival and are great resistance to chemotherapy. The objec...

    Authors: Yanwei Liu, Yanong Li, Peng Wang, Li Chen, Jin Feng and Xiaoguang Qiu

    Citation: Radiation Oncology 2021 16:157

    Content type: Research

    Published on:

  46. To investigate the treatment outcomes of passive scattering proton beam therapy using stereotactic ablative radiotherapy (SABR) or hypofractionated radiation therapy (RT) for inoperable patients or those who r...

    Authors: Unurjargal Bayasgalan, Sung Ho Moon, Jong Hwi Jeong, Tae Hyun Kim, Kwan Ho Cho and Yang-Gun Suh

    Citation: Radiation Oncology 2021 16:155

    Content type: Research

    Published on:

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