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  1. To recommend a cranial border for level IIb in delineating clinical target volumes (CTV) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy and to help reach a consensus on ...

    Authors: Lijun Wang, Shengfu Huang, Lanfang Zhang, Xia He and Yatian Liu

    Citation: Radiation Oncology 2020 15:270

    Content type: Research

    Published on:

  2. Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of seconda...

    Authors: Javier Franco-Pérez, Sergio Montes, Josué Sánchez-Hernández and Paola Ballesteros-Zebadúa

    Citation: Radiation Oncology 2020 15:269

    Content type: Research

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  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2020 15:268

    Content type: Correction

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    The original article was published in Radiation Oncology 2019 14:240

  4. Metastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced malignancy, which can result in neurologic complications and significant deterioration in overall function and qual...

    Authors: Elysia K. Donovan, Jeffrey Greenspoon, Kara L. Schnarr, Timothy J. Whelan, James R. Wright, Crystal Hann, Anthony Whitton, Tom Chow, Sameer Parpia and Anand Swaminath

    Citation: Radiation Oncology 2020 15:267

    Content type: Study protocol

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  5. Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patt...

    Authors: Lucas Basler, Robert Poel, Christina Schröder, Alessandra Bolsi, Antony Lomax, Stephanie Tanadini-Lang, Matthias Guckenberger and Damien C. Weber

    Citation: Radiation Oncology 2020 15:266

    Content type: Research

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  6. Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome of cases treated outside clinica...

    Authors: Kumiko Karasawa, Tokuhiko Omatsu, Shintaro Shiba, Daisuke Irie, Masaru Wakatsuki and Shigekazu Fukuda

    Citation: Radiation Oncology 2020 15:265

    Content type: Research

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  7. It is important to understand how elderly patients with locally advanced pancreatic carcinoma (LAPC) should be treated, since the number of elderly cancer patients will increase. However, the optimal treatment...

    Authors: Takahiro Iwai, Michio Yoshimura, Ryo Ashida, Yoko Goto, Takahiro Kishi, Satoshi Itasaka, Keiko Shibuya, Masashi Kanai, Toshihiko Masui, Akihisa Fukuda, Hiroyoshi Isoda, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2020 15:264

    Content type: Research

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  8. The spine represents the site which is most frequently affected by bone metastases in patients with systemic cancer. Of all local treatment options, combined kyphoplasty and intraoperative radiotherapy (Kypho-...

    Authors: Frederic Bludau, Laura Winter, Grit Welzel, Udo Obertacke, Frank Schneider, Frederik Wenz, Arne Mathias Ruder and Frank A. Giordano

    Citation: Radiation Oncology 2020 15:263

    Content type: Short report

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  9. Transoral surgery (TOS), particularly transoral robotic surgery (TORS) has become the preferred modality in the United States for the treatment of early stage oropharyngeal cancer, largely due to assumptions o...

    Authors: Eric J. Di Gravio, Pencilla Lang, Hugh Andrew Jinwook Kim, Tricia Chinnery, Neil Mundi, S. Danielle MacNeil, Adrian Mendez, John Yoo, Kevin Fung, Joe S. Mymryk, John W. Barrett, Nancy Read, Varagur Venkatesan, Sara Kuruvilla, Lucas C. Mendez, Eric Winquist…

    Citation: Radiation Oncology 2020 15:261

    Content type: Research

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  10. The gross tumor volume (GTV) could be an independent prognostic factor for unresectable locally advanced non-small cell lung cancer (LANSCLC). We aimed to develop and validate a novel integrated GTV-TNM strati...

    Authors: Nai-Bin Chen, Qi-Wen Li, Zheng-Fei Zhu, Yi-Ming Wang, Zhangkai J. Cheng, Zhou-Guang Hui, Su-Ping Guo, Hao-Qiang He, Bin Wang, Xiao-Yan Huang, Ji-Bin Li, Jin-Yu Guo, Nan Hu, Xin-Lei Ai, Yin Zhou, Da-Quan Wang…

    Citation: Radiation Oncology 2020 15:260

    Content type: Research

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  11. There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different typ...

    Authors: Daniela Delago, Olivia Knittelfelder, Gabriele Jakse, Katarzyna Lukasiak, Sabine Reinisch, Wilfried Renner, Heidi Stranzl-Lawatsch, Richard Partl and Tanja Langsenlehner

    Citation: Radiation Oncology 2020 15:259

    Content type: Research

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  12. This study investigates daily breast geometry and delivered dose to prone-positioned patients undergoing tangential whole breast radiation therapy (WBRT) on an O-ring linear accelerator with 6X flattening filt...

    Authors: Suk W. Yoon, Neil K. Taunk, Gary M. Freedman, Emily Hubley, Shannon O’Reilly, Boon- Keng K. Teo, Shibu Anamalayil, Lei Dong, Christopher Kennedy, Wei Zou, James M. Metz and Taoran Li

    Citation: Radiation Oncology 2020 15:258

    Content type: Research

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  13. To assess the effects of various treatment planning parameters to identify the optimal gap distance for precise two-segment total body irradiation (TBI) using helical tomotherapy (HT) with fixed jaw mode.

    Authors: HaiYang Wang, JunQi Liu, YiFei Pi, Qi Liu, Yang Mi, XiangXiang Yang, YueXin Guo and RuiTai Fan

    Citation: Radiation Oncology 2020 15:257

    Content type: Methodology

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  14. This study aimed to contrast four different irradiation methods for pediatric medulloblastoma tumors in a dosimetric comparison regarding planning target volume (PTV) coverage and sparing of organs at risk (OA...

    Authors: Gerhard Pollul, Tilman Bostel, Sascha Grossmann, Sati Akbaba, Heiko Karle, Marcus Stockinger and Heinz Schmidberger

    Citation: Radiation Oncology 2020 15:256

    Content type: Research

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  15. Recent advances in radiotherapy techniques have allowed ablative doses to be safely delivered to inoperable liver tumors. In this setting, proton beam radiotherapy (PBT) provides the means to escalate radiatio...

    Authors: Jacob S. Parzen, William Hartsell, John Chang, Smith Apisarnthanarax, Jason Molitoris, Michael Durci, Henry Tsai, James Urbanic, Jonathan Ashman, Carlos Vargas, Craig Stevens and Peyman Kabolizadeh

    Citation: Radiation Oncology 2020 15:255

    Content type: Research

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  16. Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50–60% of patients. It is part of therapy for around 40% of cancer patients who are cured of their disease. Until recently, the f...

    Authors: Madyson Colton, Eleanor J. Cheadle, Jamie Honeychurch and Tim M. Illidge

    Citation: Radiation Oncology 2020 15:254

    Content type: Review

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  17. The ESCALOX trial was designed as a multicenter, randomized prospective dose escalation study for head and neck cancer. Therefore, feasibility of treatment planning via different treatment planning systems (TP...

    Authors: Steffi U. Pigorsch, Severin Kampfer, Markus Oechsner, Michael C. Mayinger, Petra Mozes, Michal Devecka, Kerstin K. Kessel, Stephanie E. Combs and Jan J. Wilkens

    Citation: Radiation Oncology 2020 15:253

    Content type: Research

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  18. We read the article entitled “Patterns of brain metastasis immediately before prophylactic cranial irradiation (PCI): implications for PCI optimization in limited-stage small cell lung cancer” with great inter...

    Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:252

    Content type: Letter to the Editor

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  19. Whole-brain radiotherapy (WBRT) remains an important treatment for over 200,000 cancer patients in the United States annually. Hippocampal-avoidant WBRT (HA-WBRT) reduces neurocognitive toxicity compared to st...

    Authors: Christine H. Feng, Mariel Cornell, Kevin L. Moore, Roshan Karunamuni and Tyler M. Seibert

    Citation: Radiation Oncology 2020 15:251

    Content type: Research

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  20. Radiation therapy to upper abdominal sites is technically challenging due to motion of tumors and surrounding organs resulting from normal respiration. Breath-hold, using an Active Breathing Coordinator is one...

    Authors: Briana Farrugia, Richard Khor, Farshad Foroudi, Michael Chao, Kellie Knight and Caroline Wright

    Citation: Radiation Oncology 2020 15:250

    Content type: Study protocol

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  21. To develop and validate a nomogram model to predict complete response (CR) after concurrent chemoradiotherapy (CCRT) in esophageal squamous cell carcinoma (ESCC) patients using pretreatment CT radiomic features.

    Authors: He-San Luo, Shao-Fu Huang, Hong-Yao Xu, Xu-Yuan Li, Sheng-Xi Wu and De-Hua Wu

    Citation: Radiation Oncology 2020 15:249

    Content type: Research

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  22. The clonogenic assay is a versatile and frequently used tool to quantify reproductive cell survival in vitro. Current state-of-the-art analysis relies on plating efficiency-based calculations which assume a li...

    Authors: Nikko Brix, Daniel Samaga, Roman Hennel, Katharina Gehr, Horst Zitzelsberger and Kirsten Lauber

    Citation: Radiation Oncology 2020 15:248

    Content type: Research

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  23. Expression of PD-L1 is the most investigated predictor of benefit from immune checkpoint blockade in advanced NSCLC but little is known about the association of PD-L1 expression and clinicopathological paramet...

    Authors: Martina Vrankar, Izidor Kern and Karmen Stanic

    Citation: Radiation Oncology 2020 15:247

    Content type: Research

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  24. Radiation pneumonitis (RP) could be a lethal complication of lung cancer treatment. No reliable predictors of RP severity have been recognized. This prospective pilot study was performed to identify early pred...

    Authors: Samantha Aso, Arturo Navarro-Martin, Richard Castillo, Susana Padrones, Edward Castillo, Ana Montes, José Ignacio Martínez, Noelia Cubero, Rosa López, Laura Rodríguez, Ramon Palmero, Federico Manresa, Thomas Guerrero and María Molina

    Citation: Radiation Oncology 2020 15:246

    Content type: Research

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  25. Stereotactic radiation therapy (SRT) and immune checkpoint inhibitors (ICI) may act synergistically to improve treatment outcomes but may also increase the risk of symptomatic radiation necrosis (RN). The obje...

    Authors: Emily S. Kowalski, Jill S. Remick, Kai Sun, Gregory S. Alexander, Rahul Khairnar, Emily Morse, Hua-Ren Cherng, Lars J. Berg, Yannick Poirier, Narottam Lamichhane, Stewart Becker, Shifeng Chen, Jason K. Molitoris, Young Kwok, William F. Regine and Mark V. Mishra

    Citation: Radiation Oncology 2020 15:245

    Content type: Short report

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  26. There is no standard treatment for locoregional recurrent (LR) esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy (RT) previously. This retrospective study aimed to examine the effica...

    Authors: Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng and Jinming Yu

    Citation: Radiation Oncology 2020 15:243

    Content type: Research

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  27. To evaluate the applicability and estimate the radiobiological parameters of linear-quadratic Poisson tumour control probability (TCP) model for primary prostate cancer patients for two relevant target structu...

    Authors: Ilias Sachpazidis, Panayiotis Mavroidis, Constantinos Zamboglou, Christina Marie Klein, Anca-Ligia Grosu and Dimos Baltas

    Citation: Radiation Oncology 2020 15:242

    Content type: Research

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  28. Methods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim se...

    Authors: Antonello E. Spinelli, Andrea Bresolin, Stefania Zuppone, Laura Perani, Giuseppe Fallara, Nadia Di Muzio, Riccardo Vago, Claudio Fiorino and Cesare Cozzarini

    Citation: Radiation Oncology 2020 15:240

    Content type: Research

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  29. To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences.

    Authors: David J. Byun, Daniel J. Gorovets, Lauren M. Jacobs, Laura Happersett, Pengpeng Zhang, Xin Pei, Sarah Burleson, Zhigang Zhang, Margie Hunt, Sean McBride, Marisa A. Kollmeier and Michael J. Zelefsky

    Citation: Radiation Oncology 2020 15:239

    Content type: Research

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  30. Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s...

    Authors: Qing Jin, Cunzhi Lin, Xinhong Zhu, Yiwei Cao, Caihong Guo and Lijun Wang

    Citation: Radiation Oncology 2020 15:238

    Content type: Research

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  31. Nearly 50% of new gastric cancer cases and gastric cancer-related deaths worldwide occur in China. No global consensus has been reached about the optimal management of locally advanced gastric cancer. Although...

    Authors: Yongqiang Yang, Yifu Ma, Xiaoyong Xiang, Pengfei Xing, Yongyou Wu, Liyuan Zhang and Ye Tian

    Citation: Radiation Oncology 2020 15:237

    Content type: Research

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  32. There is no ideal detector-phantom combination to perform patient specific quality assurance (PSQA) for Total Marrow (TMI) and Lymphoid (TMLI) Irradiation plan. In this study, 3D dose reconstruction using mega...

    Authors: Rajesh Thiyagarajan, Dayananda Shamurailatpam Sharma, Suryakant Kaushik, Mayur Sawant, K. Ganapathy, N. Arunai Nambi Raj, Srinivas Chilukuri, Sham C. Sundar, Kartikeswar Ch. Patro, Arjunan Manikandan, M. P. Noufal, Rangasamy Sivaraman, Jose Easow and Rakesh Jalali

    Citation: Radiation Oncology 2020 15:236

    Content type: Research

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  33. Intensity-modulated radiotherapy (IMRT) improves dose homogeneity and late toxicity compared to simple tangential techniques in adjuvant whole-breast radiotherapy for patients with breast cancer. Simultaneous-...

    Authors: David Krug, Christine Köder, Matthias F. Häfner, Nathalie Arians, Semi B. Harrabi, Stefan A. Koerber, Tobias Forster, Ingmar Schlampp, Christof Sohn, Joerg Heil, Holger Hof, Juliane Hörner-Rieber and Jürgen Debus

    Citation: Radiation Oncology 2020 15:235

    Content type: Research

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  34. To evaluate the clinical outcomes of combination of androgen deprivation therapy (ADT), whole pelvic radiotherapy (WPRT), and stereotactic body radiotherapy (SBRT) boost in high-risk prostate cancer patients.

    Authors: Yeon Joo Kim, Hanjong Ahn, Choung-Soo Kim and Young Seok Kim

    Citation: Radiation Oncology 2020 15:234

    Content type: Research

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  35. Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death...

    Authors: Ali Shamseddine, Youssef H. Zeidan, Ziad El Husseini, Malek Kreidieh, Monita Al Darazi, Rim Turfa, Joseph Kattan, Ibrahim Khalifeh, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al Awabdeh, Samer Deeba, Faek Jamali, Issa Mohamad…

    Citation: Radiation Oncology 2020 15:233

    Content type: Research

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  36. This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to...

    Authors: Sheng Chang, Gang Liu, Lewei Zhao, Joshua T. Dilworth, Weili Zheng, Saada Jawad, Di Yan, Peter Chen, Craig Stevens, Peyman Kabolizadeh, Xiaoqiang Li and Xuanfeng Ding

    Citation: Radiation Oncology 2020 15:232

    Content type: Research

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  37. There is an increasing application of moderately hypofractionated radiotherapy for prostate cancer. We presented our outcomes and treatment-related toxicities with moderately hypofractionated (67.5 Gy in 25 fr...

    Authors: Lihong Yao, Jianzhong Shou, Shulian Wang, Yongwen Song, Hui Fang, Ningning Lu, Yuan Tang, Bo Chen, Shunan Qi, Yong Yang, Hao Jing, Jing Jin, Zihao Yu, Yexiong Li and Yueping Liu

    Citation: Radiation Oncology 2020 15:231

    Content type: Research

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  38. This study aimed to assess the effectiveness and cost-effectiveness of nimotuzumab in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

    Authors: Zhaodong Fei, Ting Xu, Mengying Li, Taojun Chen, Li Li, Xiufang Qiu and Chuanben Chen

    Citation: Radiation Oncology 2020 15:230

    Content type: Research

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  39. Conservative surgery followed by breast and nodal irradiation is the standard loco-regional early breast cancer (BC) treatment for patients with four or more involved lymph nodes. However, the treatment strate...

    Authors: Manuel Algara López, Elvira Rodríguez García, Inmaculada Beato Tortajada, Francisco José Martínez Arcelus, Juan Salinas Ramos, José Reyes Rodríguez garrido, Xavier Sanz Latiesas, Ana Soler Rodríguez, Germán Juan Rijo and Amanda Flaquer García

    Citation: Radiation Oncology 2020 15:229

    Content type: Study protocol

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  40. Proton pencil beam scanning (PBS) represents an interesting option for the treatment of breast cancer (BC) patients with nodal involvement. Here we compare tangential 3D-CRT and VMAT to PBS proton therapy (PT)...

    Authors: Giorgio Cartechini, Francesco Fracchiolla, Loris Menegotti, Emanuele Scifoni, Chiara La Tessa, Marco Schwarz, Paolo Farace and Francesco Tommasino

    Citation: Radiation Oncology 2020 15:228

    Content type: Research

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  41. This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a...

    Authors: Lei Peng, Jinze Li, Chunyang Meng, Jinming Li, Chengyu You, Dandan Tang, Tangqiang Wei, Wei Xiong and Yunxiang Li

    Citation: Radiation Oncology 2020 15:227

    Content type: Research

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  42. COVID-19 in Italy has led to the need to reorganize hospital protocols with a significant risk of interruption to cancer treatment programs. In this report, we will focus on a management model covering the two...

    Authors: Luciana Caravatta, Consuelo Rosa, Maria Bernadette Di Sciascio, Andrea Tavella Scaringi, Angelo Di Pilla, Lucia Anna Ursini, Maria Taraborrelli, Annamaria Vinciguerra, Antonietta Augurio, Monica Di Tommaso, Marianna Trignani, Marianna Nuzzo, Maria Daniela Falco, Andrea De Nicola, Nico Adorante, Fabiola Patani…

    Citation: Radiation Oncology 2020 15:226

    Content type: Research

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  43. Stereotactic radiosurgery (SRS) has been increasingly applied for up to 10 brain metastases instead of whole brain radiation therapy (WBRT) to achieve local tumor control while reducing neurotoxicity. Furtherm...

    Authors: Gueliz Acker, Seyed-Morteza Hashemi, Josch Fuellhase, Anne Kluge, Alfredo Conti, Markus Kufeld, Anita Kreimeier, Franziska Loebel, Melina Kord, Diana Sladek, Carmen Stromberger, Volker Budach, Peter Vajkoczy and Carolin Senger

    Citation: Radiation Oncology 2020 15:225

    Content type: Research

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  44. Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to ac...

    Authors: Jihun Kim, Ki Chang Keum, Ho Lee, Chae-Seon Hong, Kwangwoo Park and Jin Sung Kim

    Citation: Radiation Oncology 2020 15:224

    Content type: Research

    Published on:

  45. In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers. ...

    Authors: Jie Zhang, Anting Xu, Tingting Niu, Chengcheng Liu, Yongju Zhang, Tao Li, Jihua Wang, Yongjing Wang and Dianshui Sun

    Citation: Radiation Oncology 2020 15:223

    Content type: Research

    Published on:

  46. Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the ...

    Authors: Hongming Huang, Kai Sen Tan, Suizi Zhou, Tian Yuan, Jing Liu, Hsiao Hui Ong, Qianmin Chen, Junxiao Gao, Minghong Xu, Zhenchao Zhu, Qianhui Qiu and De Yun Wang

    Citation: Radiation Oncology 2020 15:222

    Content type: Research

    Published on:

  47. The prognostic significance of cardiac radiation dose in esophageal cancer after definitive concurrent chemoradiotherapy (CCRT) remains largely unknown. We aimed to investigate the association between cardiac ...

    Authors: Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Jeffrey Shu-Ming Chang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung and Forn-Chia Lin

    Citation: Radiation Oncology 2020 15:221

    Content type: Research

    Published on:

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