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  1. Brainstem metastases (BSM) are associated with a poor prognosis and their management represents a therapeutic challenge. BSM are often inoperable and, in absence of randomized trials, the optimal radiation tre...

    Authors: Luca Nicosia, Piera Navarria, Valentina Pinzi, Martina Giraffa, Ivana Russo, Paolo Tini, Niccolò Giaj-Levra, Filippo Alongi and Giuseppe Minniti
    Citation: Radiation Oncology 2022 17:140
  2. Standard treatment of soft tissue sarcoma (STS) of the extremities includes limb-sparing surgery combined with pre- or postoperative radiotherapy (RT). The role of perioperative chemotherapy (CTX) remains unce...

    Authors: Marta Kobus, Siyer Roohani, Felix Ehret, Anne Flörcken, Jana Käthe Striefler, Franziska Brandes, Sven Märdian, Daniel Rau, Silvan Wittenberg, Robert Öllinger and David Kaul
    Citation: Radiation Oncology 2022 17:139
  3. Using real-world evidence, this study aimed to identify elderly nasopharyngeal carcinoma (NPC) patients who would benefit from chemotherapy.

    Authors: Yan-Ling Wu, Kai-Bin Yang, Ying Huang, Jing-Rong Shi, Qing-Shui He, Lei Chen, Wen-Fei Li, Xiao-Dan Huang, Li Lin, Yu-Pei Chen, Yan-Ping Mao, Ling-Long Tang and Jun Ma
    Citation: Radiation Oncology 2022 17:138
  4. Langerhans cell histiocytosis (LCH) is a rare haematological neoplasm characterized by the accumulation of CD1a+, CD207/Langerin+ histiocytes within inflammatory lesions. LCH can involve any organ, but osteolytic...

    Authors: Wilmar Ghuijs, Paul G. Kemps, Marta E. Capala, Robert M. Verdijk, Astrid G. S. van Halteren, Robert J. P. van der Wal and Jan A. M. van Laar
    Citation: Radiation Oncology 2022 17:137
  5. In clinical practice, the organs at risk (OARs) should be carefully determined when performing pancreatic stereotactic body radiotherapy (SBRT). We conducted a simulation study to examine the effect of the sto...

    Authors: Osamu Tanaka, Takuya Taniguchi, Kousei Adachi, Shuto Nakaya, Takuji Kiryu, Akira Ukai, Chiyoko Makita and Masayuki Matsuo
    Citation: Radiation Oncology 2022 17:136
  6. To retrospectively analyze the efficacy and safety of concurrent chemoradiotherapy (CCRT) plus recombinant human endostatin (Endostar, CCRT + E) versus CCRT alone in locally advanced nasopharyngeal carcinoma (...

    Authors: Yuanxiu Yin, Ziyan Zhou, Zhiru Li, Mingjun Shen, Yating Qin, Chaolin Yang, Rensheng Wang and Min Kang
    Citation: Radiation Oncology 2022 17:135
  7. Definitive chemoradiotherapy has established the standard non-surgical treatment for locally advanced esophageal cancer. The standard dose of 50–50.4 Gy has been established decades ago and been confirmed in m...

    Authors: Hongcheng Zhu, Qiufang Liu, Hao Xu, Miao Mo, Zezhou Wang, Kui Lu, Jialiang Zhou, Junqiang Chen, Xiangpeng Zheng, Jinjun Ye, Xiaolin Ge, Honglei Luo, Qi Liu, Jiaying Deng, Dashan Ai, Shengnan Hao…
    Citation: Radiation Oncology 2022 17:134
  8. JCOG1015A1 is an ancillary research study to determine the organ-specific dose constraints in head and neck carcinoma treated with intensity-modulated radiation therapy (IMRT) using data from JCOG1015.

    Authors: Masahiro Inada, Yasumasa Nishimura, Satoshi Ishikura, Kazuki Ishikawa, Naoya Murakami, Takeshi Kodaira, Yoshinori Ito, Kazuhiko Tsuchiya, Yuji Murakami, Junichi Saito, Tetsuo Akimoto, Kensei Nakata, Michio Yoshimura, Teruki Teshima, Takashi Toshiyasu, Yosuke Ota…
    Citation: Radiation Oncology 2022 17:133
  9. To evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain radiotherapy (WBRT) in patients with brain metastases (BMs).

    Authors: Xue-Yi Xie, Hong-Hua Peng, Xi Zhang, Yu-Liang Pan, Zhen Zhang and Pei-Guo Cao
    Citation: Radiation Oncology 2022 17:132
  10. Dose-escalation to above 80 Gy during external beam radiotherapy for localised prostate cancer leads to improved oncological outcomes but also substantially increased rectal toxicity. The aim of this study was...

    Authors: Andrew W. See, Patrick Bowden, Geoffrey Wells, Sree Appu, Nathan Lawrentschuk, Peter Liodakis, Chloe Pandeli, Yolanda Aarons, Lloyd M. L. Smyth and Dean P. McKenzie
    Citation: Radiation Oncology 2022 17:131
  11. Increased head and neck cancer (HNC) survival requires attention to long-term treatment sequelae. Irradiated HNC survivors have a higher ischemic stroke risk. However, the pathophysiology of radiation-induced ...

    Authors: Judith T. Pruijssen, Joyce Wilbers, Frederick J. A. Meijer, Sjoert A. H. Pegge, Jacqueline J. Loonen, Chris L. de Korte, Johannes H. A. M. Kaanders and Hendrik H. G. Hansen
    Citation: Radiation Oncology 2022 17:130
  12. We describe and evaluate a deep network algorithm which automatically contours organs at risk in the thorax and pelvis on computed tomography (CT) images for radiation treatment planning.

    Authors: Sebastian Marschner, Manasi Datarb, Aurélie Gaasch, Zhoubing Xu, Sasa Grbic, Guillaume Chabin, Bernhard Geiger, Julian Rosenman, Stefanie Corradini, Maximilian Niyazi, Tobias Heimann, Christian Möhler, Fernando Vega, Claus Belka and Christian Thieke
    Citation: Radiation Oncology 2022 17:129
  13. This retrospective study was performed to evaluate the efficacy and toxicity of high-dose stereotactic body radiotherapy (SBRT) using a CyberKnife® for patients with stage I peripheral non-small cell lung canc...

    Authors: Yasuhiro Ryuno, Takanori Abe, Misaki Iino, Satoshi Saito, Tomomi Aoshika, Tomohiro Oota, Mitsunobu Igari, Ryuta Hirai, Yu Kumazaki, Kyoichi Kaira, Hiroshi Kagamu, Hironori Ishida, Shin-ei Noda and Shingo Kato
    Citation: Radiation Oncology 2022 17:128
  14. Tumor-infiltrating lymphocytes (TILs), investigated using routine hematoxylin and eosin (H&E)-stained section slides (H&E-sTILs), provide a robust prognostic biomarker in various types of solid cancer. The pur...

    Authors: Guangrun Zhou, Jifang Zheng, Zhiwei Chen, Dan Hu, Suyu Li, Wu Zhuang, Zhiyong He, Gen Lin, Biao Wu, Wei Zhang, Weimin Fang, Fei Zheng, Jiezhong Wang, Gang Chen and Mingqiu Chen
    Citation: Radiation Oncology 2022 17:127
  15. To examine long-term-survival of cT4 cN0/1 cM0 non-small-cell lung carcinoma (NSCLC) patients undergoing definitive radiochemotherapy (ccRTx/CTx) in comparison to the trimodality treatment, neoadjuvant radiochemo...

    Authors: Nika Guberina, Christoph Pöttgen, Martin Schuler, Maja Guberina, Georgios Stamatis, Till Plönes, Martin Metzenmacher, Dirk Theegarten, Thomas Gauler, Kaid Darwiche, Clemens Aigner, Wilfried E. E. Eberhardt and Martin Stuschke
    Citation: Radiation Oncology 2022 17:126
  16. tumor recurrence after NSCLC surgical resection is the most common cause of treatment failure that sharply reduces the patient’s life expectancy. The optimal treatment strategy for loco-regional recurrences de...

    Authors: Paolo Borghetti, Jessica Imbrescia, Giulia Volpi, Vieri Scotti, Michele Aquilano, Alessio Bruni, Davide Franceschini, Stefano Ursino, Patrizia Ciammella, Gaia Piperno, Maria Taraborrelli and Stefano Maria Magrini
    Citation: Radiation Oncology 2022 17:124
  17. The study evaluated the differences in leaf positioning deviations by the log files of three advanced accelerators with two delivery techniques, and established specific assessment parameters of leaf positioni...

    Authors: Xiutong Lin, Tao Sun, Xiao Liu, Guifang Zhang and Yong Yin
    Citation: Radiation Oncology 2022 17:123
  18. Dynamic trajectory radiotherapy (DTRT) extends volumetric modulated arc therapy (VMAT) with dynamic table and collimator rotation during beam-on. The aim of the study is to establish DTRT path-finding strategi...

    Authors: Jenny Bertholet, Paul-Henry Mackeprang, Silvan Mueller, Gian Guyer, Hannes A. Loebner, Yanick Wyss, Daniel Frei, Werner Volken, Olgun Elicin, Daniel M. Aebersold, Michael K. Fix and Peter Manser
    Citation: Radiation Oncology 2022 17:122
  19. Carbon ion radiotherapy (CIRT) yields biophysical advantages compared to photons but randomized studies for the reirradiation setting are pending. The aim of the current project was to evaluate potential clini...

    Authors: Thomas Held, Thomas Tessonnier, Henrik Franke, Sebastian Regnery, Lukas Bauer, Katharina Weusthof, Semi Harrabi, Klaus Herfarth, Andrea Mairani, Jürgen Debus and Sebastian Adeberg
    Citation: Radiation Oncology 2022 17:121
  20. In radiation treatment of locally advanced non-small cell lung cancer (LA-NSCLC), ‘margins’ from internal target volumes to planning target volumes in the range of 12 to 23 mm are reported, and avoiding exposu...

    Authors: Karl Wurstbauer, Margit Kazil, Marco Meinschad, Raoul Pinter, Catharina De Vries, Patrick Clemens, Christof Kreuter, Tamara Hernler, Wolfgang Hitzl, Peter Cerkl, Thomas Künzler and Alexander De Vries
    Citation: Radiation Oncology 2022 17:120
  21. Pure mucinous breast cancer is a rare subtype of invasive breast cancer with favorable prognosis, in which the effect of postoperative radiotherapy remains unclear. We aimed to investigate the prognostic value...

    Authors: Qiuping Mo, Yongzhen Wang, JinLan Shan and Xiaochen Wang
    Citation: Radiation Oncology 2022 17:119
  22. Gallbladder cancer (GBC) is an uncommon malignancy with high recurrent rate and poor prognosis. This study investigates the recurrent patterns of postoperative GBC, with the aim to guide the adjuvant treatment...

    Authors: Zhijun Yuan, Yongjie Shui, Lihong Liu, Yinglu Guo and Qichun Wei
    Citation: Radiation Oncology 2022 17:118
  23. Emerging evidence shows that immune checkpoint inhibitors lead to durable responses in a variety of cancers, including nasopharyngeal carcinoma (NPC), however, combination approaches (i.e., stereotactic body r...

    Authors: Jing Lin, Qiaojuan Guo, Zengqing Guo, Tianzhu Lu, Gang Chen, Shaojun Lin, Mei Chen, Chuanben Chen, Jianping Lu, Jingfeng Zong, Lina Tang, Yu Chen and Jianji Pan
    Citation: Radiation Oncology 2022 17:117
  24. Automated treatment planning systems are available for linear accelerator (linac)-based single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS) of brain metastases. In this study, we compared plan...

    Authors: Giorgio Hamid Raza, Luca Capone, Paolo Tini, Martina Giraffa, Piercarlo Gentile and Giuseppe Minniti
    Citation: Radiation Oncology 2022 17:116
  25. To report our experience with image guided pencil beam proton beam therapy (PBT) for craniospinal irradiation (CSI).

    Authors: Utpal Gaikwad, M. P. Noufal, Jacinthlyn Sylvia, Ashok K. Reddy, Pankaj Kumar Panda, Srinivas Chilukuri, Dayananda Sharma and Rakesh Jalali
    Citation: Radiation Oncology 2022 17:115
  26. Delineation of organs at risk (OAR) for anal cancer radiation therapy treatment planning is a manual and time-consuming process. Deep learning-based methods can accelerate and partially automate this task. The...

    Authors: Michael Lempart, Martin P. Nilsson, Jonas Scherman, Christian Jamtheim Gustafsson, Mikael Nilsson, Sara Alkner, Jens Engleson, Gabriel Adrian, Per Munck af Rosenschöld and Lars E. Olsson
    Citation: Radiation Oncology 2022 17:114
  27. To validate tumor volume-based imaging markers for predicting local recurrence-free survival (LRFS) in locoregionally advanced nasopharyngeal carcinoma patients, who underwent induction chemotherapy followed b...

    Authors: Ge Yan, Yan Feng, Mingyao Wu, Chao Li, Yiran Wei, Li Hua, Guoqi Zhao, Zhekai Hu, Shengyu Yao, Lingtong Hou, Xuming Chen, Qianqian Liu and Qian Huang
    Citation: Radiation Oncology 2022 17:111
  28. To determine PTV margins for intrafraction motion in MRI-guided online adaptive radiotherapy for rectal cancer and the potential benefit of performing a 2nd adaptation prior to irradiation.

    Authors: Chavelli M. Kensen, Tomas M. Janssen, Anja Betgen, Lisa Wiersema, Femke P. Peters, Peter Remeijer, Corrie A. M. Marijnen and Uulke A. van der Heide
    Citation: Radiation Oncology 2022 17:110
  29. To analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union Hospital Cancer Center.

    Authors: Meng-Lan Zhai, Fang-Yuan Zhang, Jin-Ru Yang, Sheng Zhang, Lei Zhao, Zhen-Yu Lin, Jing Wang, Dan-Dan Yu and Tao Zhang
    Citation: Radiation Oncology 2022 17:109
  30. Up to 30% of pancreatic cancer patients initially present locally advanced (LAPC). Stereotactic body radiation therapy (SBRT) may be an additional palliative treatment option when curative resection is no long...

    Authors: Marlies Vornhülz, Sofia Anton, Balint Eross, Zsolt Szakács, Peter Hegyi, Ivonne Regel, Claus Belka, Maximilian Niyazi, Julia Mayerle and Georg Beyer
    Citation: Radiation Oncology 2022 17:108
  31. The prescribed radiation dose to patients with oropharyngeal squamous cell carcinoma (OPSCC) is standardized, even if the prognosis for individual patients may differ. Easy-at-hand pre-treatment risk stratific...

    Authors: Gabriel Adrian, Henrik Carlsson, Elisabeth Kjellén, Johanna Sjövall, Björn Zackrisson, Per Nilsson and Maria Gebre-Medhin
    Citation: Radiation Oncology 2022 17:107
  32. The combination of transcatheter arterial chemoembolization (TACE) plus sorafenib prolonged progression-free survival (PFS) and overall survival (OS) than sorafenib or TACE monotherapy for patients with hepato...

    Authors: Jian-Xu Li, Wen-Xiang Deng, Shi-Ting Huang, Xiao-Feng Lin, Mei-Ying Long, Jie Zhang, Ting-Shi Su, Li-Qing Li, Ya-Dan Pang, Chun-Feng Liang, Hong-Mei Zhou, Hai-Yan Lu, Shi-Xiong Liang and Bang-De Xiang
    Citation: Radiation Oncology 2022 17:106
  33. This trial aims to explore the efficacy and safety of involved-field irradiation (IFI) combined with paclitaxel plus cisplatin as concurrent chemoradiotherapy for locally advanced esophageal squamous cell carc...

    Authors: Hui Li, Ying Fang, Dayong Gu, Mingyu Du, Zhi Zhang, Lei Sun, Guoren Zhou and Jinjun Ye
    Citation: Radiation Oncology 2022 17:105
  34. To propose a specific surface guided stereotactic radiotherapy (SRT) treatment procedure with open-face mask immobilization and evaluate the initial clinical experience in improving setup accuracy.

    Authors: Shun Zhou, Junyu Li, Xianggao Zhu, Yi Du, Songmao Yu, Meijiao Wang, Kaining Yao, Hao Wu and Haizhen Yue
    Citation: Radiation Oncology 2022 17:104
  35. Surgical resection with adjuvant concurrent radiochemotherapy is the standard of care for stage III–IV oral cavity cancer. In some cases, the dynamic course of the disease is out of the prepared schedule of tr...

    Authors: Paweł Polanowski, Agnieszka Pietruszka, Dorota Księżniak-Baran, Aleksandra Grządziel, Ewa Chmielik, Marek Kentnowski, Natalia Amrogowicz, Krzysztof Składowski and Katarzyna Polanowska
    Citation: Radiation Oncology 2022 17:103
  36. Stereotactic Body Radiotherapy (SBRT) is a standard treatment for inoperable primary and secondary lung tumors. In case of ultracentral tumor location, defined as tumor contact with vulnerable mediastinal stru...

    Authors: Sebastian Regnery, Jonas Ristau, Fabian Weykamp, Philipp Hoegen, Simon David Sprengel, Katharina Maria Paul, Carolin Buchele, Sebastian Klüter, Carolin Rippke, Claudia Katharina Renkamp, Moritz Pohl, Jan Meis, Thomas Welzel, Sebastian Adeberg, Stefan Alexander Koerber, Jürgen Debus…
    Citation: Radiation Oncology 2022 17:102
  37. We investigated the prognostic impact of the neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced rectal cancer (LARC) and whether modifiable factors in radiotherapy (RT) influenced the NLR.

    Authors: Gowoon Yang, Jee Suk Chang, Jeong Eun Choi, Eun Sil Baek, Seung-Seob Kim, Hwa Kyung Byun, Yeona Cho, Woong Sub Koom, Seung Yoon Yang, Byung Soh Min and Sang Joon Shin
    Citation: Radiation Oncology 2022 17:100
  38. Due to respiratory motion, accurate radiotherapy delivery to thoracic and abdominal tumors is challenging. We aimed to quantify the ability of mechanical ventilation to reduce respiratory motion, by measuring ...

    Authors: Z. van Kesteren, J. K. Veldman, M. J. Parkes, M. F. Stevens, P. Balasupramaniam, J. G. van den Aardweg, G. van Tienhoven, A. Bel and I. W. E. M. van Dijk
    Citation: Radiation Oncology 2022 17:99

    The Correction to this article has been published in Radiation Oncology 2022 17:113

  39. High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rare...

    Authors: Qiao-Xuan Wang, Shu Zhang, Wei-Wei Xiao, Cheng-Jing Zhou, Hui Chang, Zhi-Fan Zeng, Pei-Qiang Cai, Zhen-Hai Lu, Gong Chen, Pei-Rong Ding, Zhi-Zhong Pan, Xiao-Jun Wu and Yuan-Hong Gao
    Citation: Radiation Oncology 2022 17:98
  40. Radium-223 is used for the treatment of osseous metastases in castrate-resistant prostate cancer, and has been shown to increase time to the first skeletal-related event, reduce the rate of hospitalization, an...

    Authors: Julie R. Bloom, Alexandra G. Castillejos, Brianna Jones, Nimesh Patel, Barry S. Rosenstein and Richard G. Stock
    Citation: Radiation Oncology 2022 17:97
  41. This study aimed to explore the pattern of locoregional recurrence after surgery in patients with non-metastatic stage pT4 sigmoid colon cancer and the role of adjuvant radiotherapy on survival.

    Authors: Yaobin Lin, Shan Liu, Liang Hong, Lingdong Shao and Junxin Wu
    Citation: Radiation Oncology 2022 17:95
  42. To assess the feasibility of postoperative stereotactic body radiation therapy (SBRT) for patients with hybrid implants consisting of carbon fiber reinforced polyetheretherketone and titanium (CFP-T) using Cyb...

    Authors: Dominik Henzen, Daniel Schmidhalter, Gian Guyer, Anna Stenger-Weisser, Ekin Ermiş, Robert Poel, Moritz Caspar Deml, Michael Karl Fix, Peter Manser, Daniel Matthias Aebersold and Hossein Hemmatazad
    Citation: Radiation Oncology 2022 17:94
  43. In most of the views, rectal stenosis after anterior resection for rectal cancer results from pelvic radiotherapy. However, patients without receiving radiotherapy also suffer stenosis. In this study, we evalu...

    Authors: Hui Zhang, Shanshan Li, Xin Jin, Xian Wu, Zhiyuan Zhang, Lijun Shen, Juefeng Wan, Yan Wang, Yaqi Wang, Wang Yang, Menglong Zhou, Jing Zhang, Tao Lv, Yun Deng, Fan Xia and Zhen Zhang
    Citation: Radiation Oncology 2022 17:93
  44. To analyze the prognostic factors associated with stage IB-IVA cervical cancer in patients who underwent concurrent chemoradiation therapy (CCRT) and to compare the clinical toxicities and dosimetric parameter...

    Authors: Yuan-Kai Cheng, Shih-Hsun Kuo, Heng-Hsuan Yen, Jing-Hu Wu, Yu-Chieh Chen and Ming-Yii Huang
    Citation: Radiation Oncology 2022 17:91
  45. Prostate cancer is the second most common malignancy worldwide, and the majority of patients are diagnosed with localized disease. We examined patients’ quality of life after stereotactic body radiation therap...

    Authors: Hideomi Yamashita, Mami Ogita, Subaru Sawayanagi, Yuki Nozawa and Osamu Abe
    Citation: Radiation Oncology 2022 17:90

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