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  1. We aimed to explore the efficacy of orbital radiotherapy (RT) in patients with moderate-to-severe active Graves’ orbitopathy (GO), including long-lasting disease, and to determine the predictive factors associ...

    Authors: Jin Hwa Choi and Jeong Kyu Lee

    Citation: Radiation Oncology 2020 15:220

    Content type: Research

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  2. The aim of this study is to evaluate the efficacy of different treatment strategies and the potential prognostic factors of esthesioneuroblastoma (ENB).

    Authors: Meng Sun, Kai Wang, Yuan Qu, Jianghu Zhang, Shiping Zhang, Xuesong Chen, Jingbo Wang, Runye Wu, Ye Zhang, Junlin Yi, Jianping Xiao, Guozhen Xu, Xiaodong Huang and Jingwei Luo

    Citation: Radiation Oncology 2020 15:219

    Content type: Research

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  3. To compare long-term disease-related outcomes and late radiation morbidity between intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in head and neck squamous c...

    Authors: Tejpal Gupta, Shwetabh Sinha, Sarbani Ghosh-Laskar, Ashwini Budrukkar, Naveen Mummudi, Monali Swain, Reena Phurailatpam, Kumar Prabhash and Jai Prakash Agarwal

    Citation: Radiation Oncology 2020 15:218

    Content type: Research

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  4. Ultrahypofractionation using stereotactic body radiotherapy (SBRT) is an increasingly utilized technique for men with prostate cancer (PC). The comparative efficacy of SBRT plus androgen deprivation therapy (A...

    Authors: Sagar A. Patel, Jeffrey M. Switchenko, Ben Fischer-Valuck, Chao Zhang, Brent S. Rose, Ronald C. Chen, Ashesh B. Jani and Trevor J. Royce

    Citation: Radiation Oncology 2020 15:217

    Content type: Short report

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  5. In this study, we employed a gated recurrent unit (GRU)-based recurrent neural network (RNN) using dosimetric information induced by individual beam to predict the dose-volume histogram (DVH) and investigated ...

    Authors: Wufei Cao, Yongdong Zhuang, Lixin Chen and Xiaowei Liu

    Citation: Radiation Oncology 2020 15:216

    Content type: Research

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  6. To report on our clinical experience with a newly implemented workflow for radiotherapy (RT) emergency treatments, which allows for a fast treatment application outside the regular working-hours, and its clini...

    Authors: Lukas Nierer, Franziska Walter, Maximilian Niyazi, Roel Shpani, Guillaume Landry, Sebastian Marschner, Rieke von Bestenbostel, Dominika Dinkel, Gabriela Essenbach, Michael Reiner, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:215

    Content type: Research

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  7. Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-mo...

    Authors: Lukas Käsmann, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Jürgen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber and Claus Belka

    Citation: Radiation Oncology 2020 15:214

    Content type: Review

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  8. To analyze the patterns of locoregional recurrence in breast cancer patients after mastectomy.

    Authors: Xuran Zhao, Yu Tang, Shulian Wang, Yong Yang, Hui Fang, Jianyang Wang, Hao Jing, Jianghu Zhang, Guangyi Sun, Siye Chen, Jing Jin, Yongwen Song, Yueping Liu, Bo Chen, Shunan Qi, Ning Li…

    Citation: Radiation Oncology 2020 15:212

    Content type: Research

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  9. The goal of this study was to assess small bowel motion and explore the feasibility of using peritoneal space (PS) to replace bowel loops (BL) via the dose constraint method to spare the small bowel during int...

    Authors: Siyuan Li, Yanping Gong, Yongqiang Yang, Qi Guo, Jianjun Qian and Ye Tian

    Citation: Radiation Oncology 2020 15:211

    Content type: Research

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  10. Early-stage primary gastrointestinal (GI) low-grade B-cell lymphoma shows good therapeutic response to primary radiotherapy. However, there is no clear guideline for the evaluation of response to radiation the...

    Authors: Kyu Hye Choi, Han Hee Lee, Seung-Eun Jung, Kyung-Sin Park, Joo-Hyun O, Young-Woo Jeon, Byung-Ock Choi and Seok-Goo Cho

    Citation: Radiation Oncology 2020 15:210

    Content type: Research

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  11. Treatment for locally recurrent rectal cancer after surgery is still a challenge. With the physical and biological advantages, carbon-ion radiotherapy (CIRT) could be a choice for these patients. The purpose o...

    Authors: Xin Cai, Yueyao Du, Zheng Wang, Ping Li, Zhan Yu, Qing Zhang and Zhen Zhang

    Citation: Radiation Oncology 2020 15:209

    Content type: Research

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  12. To perform a clinical audit to assess adherence to standard clinical practice for the diagnosis, treatment, and follow-up of patients undergoing radiotherapy for rectal cancer treatment in four European countr...

    Authors: Magdalena Fundowicz, Artur Aguiar, Carla Lopes de Castro, Maria Glòria Torras, Letizia Deantonio, Ewelina Konstanty, Marta Kruszyna-Mochalska, Miquel Macia, Eugeni Canals, Monica Caro, Carla Pisani, Dorota Zwierzchowska, Jaume Molero, Arantxa Eraso, Joana Lencart, Carles Muñoz-Montplet…

    Citation: Radiation Oncology 2020 15:208

    Content type: Review

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  13. There was no study investigating real-world utilization and outcome of LCT in Osimertinib-treated NSCLC with oligo-residual disease. This study was to analyze the clinical value of local consolidative therapy ...

    Authors: Ya Zeng, Jianjiao Ni, Fan Yu, Yue Zhou, Yang Zhao, Shuyan Li, Tiantian Guo, Li Chu, Xi Yang, Xiao Chu, Xuwei Cai and Zhengfei Zhu

    Citation: Radiation Oncology 2020 15:207

    Content type: Research

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  14. This study aimed to analyze the oncological long-term results and late toxicity of carbon ion-based radiotherapy (RT) of patients with sacral chordoma and to identify potential prognostic factors for local con...

    Authors: Tilman Bostel, Matthias Mattke, Nils Henrik Nicolay, Thomas Welzel, Daniel Wollschläger, Sati Akbaba, Arnulf Mayer, Tanja Sprave, Jürgen Debus and Matthias Uhl

    Citation: Radiation Oncology 2020 15:206

    Content type: Research

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  15. To assess the efficacy and safety of recombinant human endostatin in combination with radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) in patients with locally advanced non-small cell lung cancer (LA-N...

    Authors: Shu-Ling Zhang, Cheng-Bo Han, Li Sun, Le-Tian Huang and Jie-Tao Ma

    Citation: Radiation Oncology 2020 15:205

    Content type: Research

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  16. To perform quantitative analysis on the efficacy of using relative cerebral blood flow (rCBF) in arterial spin labeling (ASL), relative cerebral blood volume (rCBV) in dynamic magnetic sensitivity contrast-enh...

    Authors: Jixin Luan, Mingzhen Wu, Xiaohui Wang, Lishan Qiao, Guifang Guo and Chuanchen Zhang

    Citation: Radiation Oncology 2020 15:204

    Content type: Research

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  17. Online adaptive radiotherapy is intended to prevent plan degradation caused by inter-fractional tumor volume and shape changes, but time limitations make online re-planning challenging. The aim of this study w...

    Authors: Janita E. van Timmeren, Madalyne Chamberlain, Jérôme Krayenbuehl, Lotte Wilke, Stefanie Ehrbar, Marta Bogowicz, Callum Hartley, Mariangela Zamburlini, Nicolaus Andratschke, Helena Garcia Schüler, Matea Pavic, Panagiotis Balermpas, Chaehee Ryu, Matthias Guckenberger and Stephanie Tanadini-Lang

    Citation: Radiation Oncology 2020 15:203

    Content type: Research

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  18. In head and neck cancer (HNC), the relationship between a delay in starting radiotherapy (RT) and the outcome is unclear. The aim of the present study was to determine the impact of the amount of time before t...

    Authors: Barbara Žumer, Maja Pohar Perme, Simona Jereb and Primož Strojan

    Citation: Radiation Oncology 2020 15:202

    Content type: Research

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  19. Radiotherapy for breast cancer (BC) and its resulting cardiac exposure are associated with subclinical left ventricular dysfunction characterized by early decrease of global longitudinal strain (LS) measuremen...

    Authors: Valentin Walker, Olivier Lairez, Olivier Fondard, Gaëlle Jimenez, Jérémy Camilleri, Loïc Panh, David Broggio, Marie-Odile Bernier, Dominique Laurier, Jean Ferrières and Sophie Jacob

    Citation: Radiation Oncology 2020 15:201

    Content type: Research

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  20. Immobilization devices are crucial to minimize patient positioning uncertainties in radiotherapy (RT) treatments. Accurate inter and intra-fraction motions is particularly important for intracranial and stereo...

    Authors: Chin Loon Ong, Niccolò Giaj-Levra, Luca Nicosia, Vanessa Figlia, Davide Tomasini, Eric M. Franken and Filippo Alongi

    Citation: Radiation Oncology 2020 15:200

    Content type: Research

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  21. We read the article entitled “Impact of hydrogel peri-rectal spacer insertion on prostate gland intra-fraction motion during 1.5 T MR-guided stereotactic body radiotherapy” with great interest. In that study, ...

    Authors: Hamed Ghaffari, Mahmoud Navaser and Soheila Refahi

    Citation: Radiation Oncology 2020 15:199

    Content type: Letter to the Editor

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  22. Although the 21-gene recurrence score (RS) assay is widely used to predict distant recurrence risk and benefit from adjuvant chemotherapy among women with hormone receptor-positive (HR+) breast cancer, the rel...

    Authors: David D. Yang, Daniela L. Buscariollo, Angel M. Cronin, Shicheng Weng, Melissa E. Hughes, Richard J. Bleicher, Adam L. Cohen, Sara H. Javid, Stephen B. Edge, Beverly Moy, Joyce C. Niland, Antonio C. Wolff, Michael J. Hassett and Rinaa S. Punglia

    Citation: Radiation Oncology 2020 15:198

    Content type: Research

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  23. Radiotherapy (RT) is applied in 45–60% of all cancer patients either alone or in multimodal therapy concepts comprising surgery, RT and chemotherapy. However, despite technical innovations approximately only 5...

    Authors: Kexu Xiang, Verena Jendrossek and Johann Matschke

    Citation: Radiation Oncology 2020 15:197

    Content type: Review

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  24. Patients with resected oral cavity squamous cell carcinoma (OCSCC) are often treated with adjuvant radiation (RT) ± concomitant chemotherapy based on pathological findings. Standard RT volumes include all surg...

    Authors: Pencilla Lang, Jessika Contreras, Noah Kalman, Claire Paterson, Houda Bahig, Astrid Billfalk-Kelly, Sinead Brennan, Kathy Rock, Nancy Read, Varagur Venkatesan, Jinka Sathya, Lucas C. Mendez, S. Danielle MacNeil, Anthony C. Nichols, Kevin Fung, Adrian Mendez…

    Citation: Radiation Oncology 2020 15:196

    Content type: Study protocol

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  25. Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon i...

    Authors: Shintaro Shiba, Kei Shibuya, Masahiko Okamoto, Shohei Okazaki, Shuichiro Komatsu, Yoshiki Kubota, Takashi Nakano and Tatsuya Ohno

    Citation: Radiation Oncology 2020 15:195

    Content type: Research

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  26. We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).

    Authors: Yin-Yin Chiang, Yung-Chih Chou, Kai-Ping Chang, Chun-Ta Liao, Yao-Yu Wu, Wing-Keen Yap, Ping-Ching Pai, Joseph Tung-Chieh Chang, Chien-Yu Lin, Kang-Hsing Fan, Bing-Shen Huang, Tsung-Min Hung and Ngan-Ming Tsang

    Citation: Radiation Oncology 2020 15:194

    Content type: Research

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  27. This study was an open-label, 2-arms, monocentric, randomized clinical trial comparing Xonrid®, a topical medical device, versus standard of care (SOC) in preventing and treating acute radiation dermatitis (AR...

    Authors: Rossana Ingargiola, Maria Carmen De Santis, Nicola Alessandro Iacovelli, Nadia Facchinetti, Anna Cavallo, Eliana Ivaldi, Michela Dispinzieri, Marzia Franceschini, Carlotta Giandini, Domenico Attilio Romanello, Simona Di Biaso, Michela Sabetti, Laura Locati, Salvatore Alfieri, Paolo Bossi, Mauro Guglielmo…

    Citation: Radiation Oncology 2020 15:193

    Content type: Research

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  28. To develop a low-dose cone beam CT (LD-CBCT) reconstruction method named simultaneous algebraic reconstruction technique and dual-dictionary learning (SART-DDL) joint algorithm for image guided radiation thera...

    Authors: Ying Song, Weikang Zhang, Hong Zhang, Qiang Wang, Qing Xiao, Zhibing Li, Xing Wei, Jialu Lai, Xuetao Wang, Wan Li, Quan Zhong, Pan Gong, Renming Zhong and Jun Zhao

    Citation: Radiation Oncology 2020 15:192

    Content type: Research

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  29. Coronavirus Disease 2019 (COVID-19) pandemic had an overwhelming impact on healthcare worldwide. Outstandingly, the aftermath on neoplastic patients is still largely unknown, and only isolated cases of COVID-1...

    Authors: Michela Buglione, Luigi Spiazzi, Andrea Emanuele Guerini, Fernando Barbera, Nadia Pasinetti, Ludovica Pegurri, Luca Triggiani, Davide Tomasini, Diana Greco, Gianluca Costantino, Alessandra Bragaglio, Nadia Bonometti, Mara Liccioli, Lorella Mascaro, Filippo Alongi and Stefano Maria Magrini

    Citation: Radiation Oncology 2020 15:191

    Content type: Research

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  30. Intensity-modulated re-radiotherapy (reIMRT) has been established as a standard local treatment option in patients with non-resectable, recurrent head and neck cancer (rHNC). However, the clinical outcome is u...

    Authors: Thomas Held, Kristin Lang, Sebastian Regnery, Katharina Weusthof, Adriane Hommertgen, Cornelia Jäkel, Eric Tonndorf-Martini, Johannes Krisam, Peter Plinkert, Karim Zaoui, Christian Freudlsperger, Julius Moratin, Jürgen Krauss, Semi B. Harrabi, Klaus Herfarth, Jürgen Debus…

    Citation: Radiation Oncology 2020 15:190

    Content type: Study protocol

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  31. Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late di...

    Authors: Q. Li, S. H. Maier, P. Li, J. Peterhansl, C. Belka, J. Mayerle and U. M. Mahajan

    Citation: Radiation Oncology 2020 15:189

    Content type: Review

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  32. To investigate the feasibility of a knowledge-based automated intensity-modulated radiation therapy (IMRT) planning technique for locally advanced nasopharyngeal carcinoma (NPC) radiotherapy.

    Authors: Penggang Bai, Xing Weng, Kerun Quan, Jihong Chen, Yitao Dai, Yuanji Xu, Fasheng Lin, Jing Zhong, Tianming Wu and Chuanben Chen

    Citation: Radiation Oncology 2020 15:188

    Content type: Research

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  33. The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. Although t...

    Authors: P. Freislederer, M. Kügele, M. Öllers, A. Swinnen, T.-O. Sauer, C. Bert, D. Giantsoudi, S. Corradini and V. Batista

    Citation: Radiation Oncology 2020 15:187

    Content type: Review

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  34. Leptomeningeal metastasis (LM) is a rare but detrimental complication in patients with non-small cell lung cancer (NSCLC). Although whole brain radiotherapy (WBRT) is used to eliminating cancer cells or micros...

    Authors: Junjie Zhen, Lei Wen, Mingyao Lai, Zhaoming Zhou, Changguo Shan, Shaoqun Li, Tao Lin, Jie Wu, Wensheng Wang, Shaoqiang Xu, Da Liu, Ming Lu, Dan Zhu, Longhua Chen, Linbo Cai and Cheng Zhou

    Citation: Radiation Oncology 2020 15:185

    Content type: Research

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  35. To identify the association between somatic ataxia-telangiectasia mutated (ATM) mutations and improved radio-sensitivity, we retrospectively reviewed next-generation sequencing data from patients diagnosed with i...

    Authors: Nalee Kim, Se Hoon Kim, Seok-Gu Kang, Ju Hyung Moon, Jaeho Cho, Chang-Ok Suh, Hong In Yoon and Jong Hee Chang

    Citation: Radiation Oncology 2020 15:184

    Content type: Research

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  36. We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation ind...

    Authors: Martin Selmansberger, Agata Michna, Herbert Braselmann, Ines Höfig, Kenji Schorpp, Peter Weber, Natasa Anastasov, Horst Zitzelsberger, Julia Hess and Kristian Unger

    Citation: Radiation Oncology 2020 15:182

    Content type: Research

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  37. Automatic tumor segmentation based on Convolutional Neural Networks (CNNs) has shown to be a valuable tool in treatment planning and clinical decision making. We investigate the influence of 7 MRI input channe...

    Authors: Lars Bielak, Nicole Wiedenmann, Arnie Berlin, Nils Henrik Nicolay, Deepa Darshini Gunashekar, Leonard Hägele, Thomas Lottner, Anca-Ligia Grosu and Michael Bock

    Citation: Radiation Oncology 2020 15:181

    Content type: Research

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  38. To test the efficacy and feasibility of pelvic bone marrow sparing intensity modulated radiotherapy (PBMS-IMRT) in reducing grade 2 or higher hematological toxicity (HT2+) for patients with cervical cancer tre...

    Authors: Jin Huang, Fei Gu, Tianlong Ji, Jing Zhao and Guang Li

    Citation: Radiation Oncology 2020 15:180

    Content type: Research

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  39. Locally recurrent rectal cancer (LRRC) after surgery or external beam radiotherapy (EBRT) is a serious challenge for which no standard treatment is defined. In the present study, we investigated the feasibilit...

    Authors: Lu Wang, Hao Wang, Yuliang Jiang, Zhe Ji, Fuxin Guo, Ping Jiang, Xuemin Li, Yi Chen, Haitao Sun, Jinghong Fan, Weiyan Li, Xu Li and Junjie Wang

    Citation: Radiation Oncology 2020 15:179

    Content type: Research

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  40. The assessment of organ motion is a crucial feature for prostate stereotactic body radiotherapy (SBRT). Rectal spacer may represent a helpful device in order to outdistance rectal wall from clinical target, bu...

    Authors: Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Vanessa Figlia, Niccolò Giaj-Levra, Francesco Ricchetti, Michele Rigo, Claudio Vitale, Beatrice Mantoan, Antonio De Simone, Gianluisa Sicignano, Ruggero Ruggieri, Stefano Cavalleri and Filippo Alongi

    Citation: Radiation Oncology 2020 15:178

    Content type: Research

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  41. Chronic encapsulated intracerebral hematomas (CEIHs) are a rare, late complication of radiosurgery for intracranial AVM. We present 5 cases treated mostly by surgical excision and review the literature.

    Authors: Stephanos Finitsis, Valerie Bernier, Isabelle Buccheit, Olivier Klein, Serge Bracard, Francois Zhu, Guillaume Gauchotte and René Anxionnat

    Citation: Radiation Oncology 2020 15:177

    Content type: Research

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  42. Impaired function of masticatory muscles will lead to trismus. Routine delineation of these muscles during planning may improve dose tracking and facilitate dose reduction resulting in decreased radiation-rela...

    Authors: Wen Chen, Yimin Li, Brandon A. Dyer, Xue Feng, Shyam Rao, Stanley H. Benedict, Quan Chen and Yi Rong

    Citation: Radiation Oncology 2020 15:176

    Content type: Research

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  43. Total scalp irradiation presents technical and dosimetric challenges. While reports suggest that HyperArc, a new stereotactic radiosurgery planning technique applied to non-coplanar volumetric-modulated arc th...

    Authors: Shoki Inui, Yoshihiro Ueda, Shingo Ohira, Haruhi Tsuru, Masaru Isono, Masayoshi Miyazaki, Masahiko Koizumi and Teruki Teshima

    Citation: Radiation Oncology 2020 15:175

    Content type: Research

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  44. Lentigo maligna (LM) is the most common subtype of in situ melanoma und occurs frequently in the sun-exposed head and neck region in elderly patients. The therapeutic “gold standard” is surgical excision, as t...

    Authors: Alexandra Hendrickx, Antonio Cozzio, Ludwig Plasswilm and Cédric M. Panje

    Citation: Radiation Oncology 2020 15:174

    Content type: Review

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  45. The use of stereotactic body radiotherapy (SBRT) as the primary treatment modality in clinically localized prostate cancer (PCa) is emerging. The aim of the study was to analyze the long-term results of PCa pa...

    Authors: Kristiina Vuolukka, Päivi Auvinen, Erno Tiainen, Jan-Erik Palmgren, Janne Heikkilä, Jan Seppälä, Sirpa Aaltomaa and Vesa Kataja

    Citation: Radiation Oncology 2020 15:173

    Content type: Research

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  46. This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework include...

    Authors: E. J. Her, A. Haworth, H. M. Reynolds, Y. Sun, A. Kennedy, V. Panettieri, M. Bangert, S. Williams and M. A. Ebert

    Citation: Radiation Oncology 2020 15:172

    Content type: Research

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  47. To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...

    Authors: T. Bostel, C. Dreher, D. Wollschläger, A. Mayer, F. König, S. Bickelhaupt, H. P. Schlemmer, P. E. Huber, F. Sterzing, P. Bäumer, J. Debus and N. H. Nicolay

    Citation: Radiation Oncology 2020 15:171

    Content type: Research

    Published on:

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