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  1. Intensity-modulated radiation therapy (IMRT) and volume-modulated arc therapy (VMAT) are rather complex treatment techniques and require patient-specific quality assurance procedures. Electronic portal imaging...

    Authors: Jun Zhang, Xiuqing Li, Miaomiao Lu, Qilin Zhang, Xile Zhang, Ruijie Yang, Maria F. Chan and Junhai Wen

    Citation: Radiation Oncology 2021 16:232

    Content type: Research

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  2. Immunotherapy has been administered to many patients with non-small-cell lung cancer (NSCLC). However, only few studies have examined toxicity in patients receiving an immune checkpoint inhibitor (ICI) after c...

    Authors: Jeong Yun Jang, Su Ssan Kim, Si Yeol Song, Yeon Joo Kim, Sung-woo Kim and Eun Kyung Choi

    Citation: Radiation Oncology 2021 16:231

    Content type: Research

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  3. Authors: Catherine R. Hanna, Sean M. O’Cathail, Janet S. Graham, Mark Saunders, Leslie Samuel, Mark Harrison, Lynsey Devlin, Joanne Edwards, Daniel R. Gaya, Caroline A. Kelly, Liz-Anne Lewsley, Noori Maka, Paula Morrison, Louise Dinnett, Susan Dillon, Jacqueline Gourlay…

    Citation: Radiation Oncology 2021 16:230

    Content type: Correction

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    The original article was published in Radiation Oncology 2021 16:163

  4. To identify the subset of patients with de novo nasopharyngeal carcinoma (NPC) for whom [18F] fluorodeoxyglucose positron emission tomography and computed tomography (18F-FDG PET/CT) should be recommended, and to...

    Authors: Chuanben Chen, Ting Xu, Xiufang Qiu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Taojun Chen, Li Li, Jing Liu and Zhaodong Fei

    Citation: Radiation Oncology 2021 16:229

    Content type: Research

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  5. Neuroblastoma is a common extracranial malignant tumor in children. Its main treatment modality is a combination of chemotherapy, radiotherapy, and surgery. Given the advances in chemotherapy regimens and the ...

    Authors: Hongnan Zhen, Hui Guan, Jiabin Ma, Wenhui Wang, Shen Jing, Zheng Miao, Fuquan Zhang and Zhikai Liu

    Citation: Radiation Oncology 2021 16:228

    Content type: Research

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  6. As cancer is developing into a chronic disease due to longer survival, continuity and coordination of oncological care are becoming more important for patients. As radiation oncology departments are an integra...

    Authors: Sebastian M. Christ, Maiwand Ahmadsei, Annina Seiler, Eugenia Vlaskou Badra, Jonas Willmann, Caroline Hertler and Matthias Guckenberger

    Citation: Radiation Oncology 2021 16:227

    Content type: Research

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  7. This study presents patient-specific quality assurance (QA) results from the first 395 clinical cases for the new helical TomoTherapy® platform (Radixact) coupled with dedicated Precision TPS.

    Authors: Marco Fusella, Samuele Cavinato, Alessandra Germani, Marta Paiusco, Nicola Pivato, Marco Andrea Rossato, Anthony Scott and Alessandro Scaggion

    Citation: Radiation Oncology 2021 16:226

    Content type: Research

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  8. Over the past decades, remarkable advancements in systemic drug therapy have improved the prognosis of patients with bone metastases. Individualization is required in external beam radiotherapy (EBRT) for bone...

    Authors: Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Masaaki Kataoka, Shuhei Yamamoto, Kei Nagasaki, Hirofumi Ishikawa, Noriko Takata, Shintaro Tsuruoka, Kotaro Uwatsu and Teruhito Kido

    Citation: Radiation Oncology 2021 16:225

    Content type: Research

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  9. We aim to assess the risks associated with total body irradiation (TBI) delivered using a commercial dedicated Co-60 irradiator, and to evaluate inter-institutional and inter-professional variations in the est...

    Authors: Shahbaz Ahmed, Todd Bossenberger, Adrian Nalichowski, Jeremy S. Bredfeldt, Sarah Bartlett, Kristen Bertone, Michael Dominello, Mark Dziemianowicz, Melanie Komajda, G. Mike Makrigiorgos, Karen J. Marcus, Andrea Ng, Marvin Thomas and Jay Burmeister

    Citation: Radiation Oncology 2021 16:224

    Content type: Research

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  10. The purpose of this study was to compare the treatment efficacy and safety of re-irradiation (re-RT) using stereotactic ablative radiotherapy (SABR) and initial SABR for primary, recurrent lung cancer or metas...

    Authors: Tae Hoon Lee, Dong-Yun Kim, Hong-Gyun Wu, Joo Ho Lee and Hak Jae Kim

    Citation: Radiation Oncology 2021 16:222

    Content type: Research

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  11. To communicate our institutional experience with single isocenter radiosurgery treatments for multiple brain metastases, including challenges with determining planning target volume (PTV) margins and resulting...

    Authors: Nzhde Agazaryan, Steve Tenn, Chul Lee, Michael Steinberg, John Hegde, Robert Chin, Nader Pouratian, Isaac Yang, Won Kim and Tania Kaprealian

    Citation: Radiation Oncology 2021 16:221

    Content type: Research

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  12. The purpose of this study was to develop a model using dose volume histogram (DVH) and dosiomic features to predict the risk of radiation pneumonitis (RP) in the treatment of esophageal cancer with radiation t...

    Authors: Chanon Puttanawarut, Nat Sirirutbunkajorn, Suphalak Khachonkham, Poompis Pattaranutaporn and Yodchanan Wongsawat

    Citation: Radiation Oncology 2021 16:220

    Content type: Research

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  13. Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a standard treatment modality for locally-advanced esophageal cancer. However, patients who achieve clinical complete response (cCR) after nCRT have ...

    Authors: Jaehyeon Park, Ji Woon Yea, Se An Oh and Jae Won Park

    Citation: Radiation Oncology 2021 16:219

    Content type: Research

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  14. To determine the optimal volume of barium for oesophageal localisation on cone-beam CT (CBCT) for locally-advanced non-small cell lung cancers (NSCLC) and quantify the interfraction oesophageal movement relati...

    Authors: Katrina Woodford, Vanessa Panettieri, Jeremy D. Ruben, Sidney Davis, Trieumy Tran Le, Stephanie Miller and Sashendra Senthi

    Citation: Radiation Oncology 2021 16:218

    Content type: Research

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  15. Main purpose was to describe procedures and identify challenges in the implementation process of adaptive and non-adaptive MR-guided radiotherapy (MRgRT), especially new risks in workflow due to the new techni...

    Authors: Helena Isabel Garcia Schüler, Matea Pavic, Michael Mayinger, Nienke Weitkamp, Madalyne Chamberlain, Cäcilia Reiner, Claudia Linsenmeier, Panagiotis Balermpas, Jerome Krayenbühl, Matthias Guckenberger, Michael Baumgartl, Lotte Wilke, Stephanie Tanadini-Lang and Nicolaus Andratschke

    Citation: Radiation Oncology 2021 16:217

    Content type: Research

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  16. Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selecti...

    Authors: Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu and Junjie Wang

    Citation: Radiation Oncology 2021 16:216

    Content type: Review

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  17. To evaluate the efficacy of concurrent chemoradiotherapy (CCRT) in subgroups of stage III nasopharyngeal carcinoma (NPC) in the context of intensity-modulated radiotherapy (IMRT).

    Authors: Lei Wang, Zheng Wu, Wanqin Cheng, Dehuan Xie, Feifei Lin, Liangping Xia and Yong Su

    Citation: Radiation Oncology 2021 16:215

    Content type: Research

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  18. To implement a tangential treatment technique for whole breast irradiation using the Varian Halcyon and to compare it with Elekta Synergy Agility plans.

    Authors: Anne Richter, Sonja Wegener, Kathrin Breuer, Gary Razinskas, Stefan Weick, Florian Exner, Klaus Bratengeier, Michael Flentje, Otto Sauer and Bülent Polat

    Citation: Radiation Oncology 2021 16:213

    Content type: Research

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  19. Androgen deprivation therapy (ADT) used for prostate cancer (PCa) management is associated with metabolic and anthropometric toxicity. Metformin given concurrent to ADT is hypothesized to counteract these chan...

    Authors: Julian O. Kim, Megan O. McDonald, Aldrich Ong, Rashmi Koul, Arbind Dubey, William Hunter, Shahida Ahmed, Harvey Quon, Don Yee, Matthew Parliament, Gokulan Sivananthan, Brita Danielson, Lindsay Rowe, Sunita Ghosh and Nawaid Usmani

    Citation: Radiation Oncology 2021 16:212

    Content type: Short report

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  20. Radiotherapy may work synergistically with immunotherapy and targeted agents. We aimed to assess the safety and outcomes of stereotactic body radiotherapy (SBRT) plus non-first-line programmed death-1 (PD-1) i...

    Authors: Yang Liu, Zhiling Zhang, Ruiqi Liu, Wensu Wei, Zitong Zhang, Lixin Mai, Shengjie Guo, Hui Han, Fangjian Zhou, Liru He and Pei Dong

    Citation: Radiation Oncology 2021 16:211

    Content type: Research

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  21. Radiotherapy (RT) might lead to atherosclerotic plaque buildup and coronary artery stenosis of breast cancer (BC) survivors, and coronary artery calcium (CAC) might be a sign of preclinical atherosclerosis. Th...

    Authors: Yu-Hsuan Lai, Helen H. W. Chen and Yi-Shan Tsai

    Citation: Radiation Oncology 2021 16:210

    Content type: Research

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  22. In-vivo dosimetry (IVD) is a patient specific measure of quality control and safety during radiotherapy. With regard to current reporting thresholds for significant occurrences in radiotherapy defined by Germa...

    Authors: Sebastian Höfel, Matteo Gandalini, Michael K. Fix, Malte Drescher and Felix Zwicker

    Citation: Radiation Oncology 2021 16:209

    Content type: Research

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  23. Through recent advances in cancer care, the number of long-term survivors has continuously increased. As a result, repetitive use of local radiotherapy for curative or palliative indications might have increas...

    Authors: Sebastian M. Christ, Maiwand Ahmadsei, Lotte Wilke, Anja Kühnis, Matea Pavic, Stephanie Tanadini-Lang and Matthias Guckenberger

    Citation: Radiation Oncology 2021 16:208

    Content type: Research

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  24. There is still no definitely therapeutic evidence of a beneficial effect of chemotherapy with radiotherapy for older patients with esophageal squamous cell carcinoma (ESCC). We aim to determine the influence o...

    Authors: Haishan Wu, Yilin Yu, Qunhao Zheng, Tianxiu Liu, Yahua Wu, Zhiping Wang, Hongying Zheng, Lingyun Liu and Jiancheng Li

    Citation: Radiation Oncology 2021 16:207

    Content type: Research

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  25. In the existing application of beam-matched multiroom proton therapy system, the model based on the commissioning data from the leading treatment room was used as the shared model. The purpose of this study is...

    Authors: Yu-Hua Huang, Chunfeng Fang, Tao Yang, Lin Cao, Gaolong Zhang, Baolin Qu, Yihang Zhang, Zishen Wang and Shouping Xu

    Citation: Radiation Oncology 2021 16:206

    Content type: Research

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  26. Evaluation of delivered dose to the dominant intraprostatic lesion (DIL) for moderately hypofractionated radiotherapy of prostate cancer by cone beam computed tomography (CBCT)-based dose accumulation and targ...

    Authors: Jörg Tamihardja, Sinan Cirsi, Patrick Kessler, Gary Razinskas, Florian Exner, Anne Richter, Bülent Polat and Michael Flentje

    Citation: Radiation Oncology 2021 16:205

    Content type: Research

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  27. The COVID-19 pandemic has stripped many medical students worldwide of their right to quality education. In response, we developed hybrid courses involving aspects of both online and in-person teaching for radi...

    Authors: Tae Hyung Kim, Jin Sung Kim, Hong In Yoon, Joongyo Lee, Jason Joon Bock Lee, Hwa Kyung Byun, Yeona Cho, Yong Bae Kim, Ik Jae Lee, Kyung Hwan Kim and Jee Suk Chang

    Citation: Radiation Oncology 2021 16:204

    Content type: Research

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  28. To study the performance of a proposed deep learning-based autocontouring system in delineating organs at risk (OARs) in breast radiotherapy with a group of experts.

    Authors: Hwa Kyung Byun, Jee Suk Chang, Min Seo Choi, Jaehee Chun, Jinhong Jung, Chiyoung Jeong, Jin Sung Kim, Yongjin Chang, Seung Yeun Chung, Seungryul Lee and Yong Bae Kim

    Citation: Radiation Oncology 2021 16:203

    Content type: Research

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  29. To develop high-quality synthetic CT (sCT) generation method from low-dose cone-beam CT (CBCT) images by using attention-guided generative adversarial networks (AGGAN) and apply these images to dose calculatio...

    Authors: Liugang Gao, Kai Xie, Xiaojin Wu, Zhengda Lu, Chunying Li, Jiawei Sun, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2021 16:202

    Content type: Research

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  30. To develop a nomogram model for predicting local progress-free survival (LPFS) in esophageal squamous cell carcinoma (ESCC) patients treated with concurrent chemo-radiotherapy (CCRT).

    Authors: He-San Luo, Ying-Ying Chen, Wei-Zhen Huang, Sheng-Xi Wu, Shao-Fu Huang, Hong-Yao Xu, Ren-Liang Xue, Ze-Sen Du, Xu-Yuan Li, Lian-Xin Lin and He-Cheng Huang

    Citation: Radiation Oncology 2021 16:201

    Content type: Research

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  31. Hypoxia is known to be prevalent in solid tumors such as non-small cell lung cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET imaging can provide in-vivo hypoxia measurements...

    Authors: Andreas Köthe, Nicola Bizzocchi, Sairos Safai, Antony John Lomax, Damien Charles Weber and Giovanni Fattori

    Citation: Radiation Oncology 2021 16:199

    Content type: Research

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  32. Second head and neck neuroendocrine carcinoma (NEC) after radical radiotherapy for nasopharyngeal carcinoma (NPC) treatment is rarely reported. The prognosis of second cancer is poor, and our research focuses ...

    Authors: Ying-peng Peng, Qiao-dan Liu, Yu-jing Lin, Shun-li Peng, Rong Wang, Xi-wei Xu, Wei Wei, Gui-hua Zhong, Yu-ling Zhou, Ya-qin Zhang, Ye Liu, Si-yang Wang, Hai-yu Hong and Zhi-gang Liu

    Citation: Radiation Oncology 2021 16:198

    Content type: Research

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  33. Approximately one third of cancer patients will develop spinal metastases, that can be associated with back pain, neurological symptoms and deterioration in performance status. Stereotactic radiosurgery (SRS) ...

    Authors: Niccolò Giaj-Levra, Vanessa Figlia, Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attinà, Claudio Vitale, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Filippo Alongi

    Citation: Radiation Oncology 2021 16:197

    Content type: Research

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  34. Adjuvant therapy is a promising treatment to improve the prognosis of cancer patients, however, the evidence base driving recommendations for adjuvant radiotherapy (ART) or chemotherapy (ACT) in retroperitonea...

    Authors: Xiangji Li, Tong Wu, Mengmeng Xiao, Shanshan Wu, Li Min and Chenghua Luo

    Citation: Radiation Oncology 2021 16:196

    Content type: Research

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  35. Whether adjuvant chemotherapy (AC) after concurrent chemoradiotherapy (CCRT) could provide benefit to esophageal squamous cell carcinoma (ESCC) patients is controversial. Therefore, we decided to investigate t...

    Authors: Ao Liu, Yalin Wang, Xin Wang, Liqiong Zhu, Yu Nie and Minghuan Li

    Citation: Radiation Oncology 2021 16:195

    Content type: Research

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  36. Systemic response to local anticancer treatment is a phenomenon called ‘abscopal effect’. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, parti...

    Authors: Oliver Vilinovszki, Nicolaus Andratschke, Martin Huellner, Alessandra Curioni-Fontecedro and Stephanie G. C. Kroeze

    Citation: Radiation Oncology 2021 16:194

    Content type: Case report

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  37. Stereotactic body radiotherapy (SBRT) is increasingly used for treatment of liver tumors but the effect on metabolic liver function in surrounding tissue is largely unknown. Using 2-deoxy-2-[18F]fluoro-d-galactos...

    Authors: Michael Sørensen, Mette Marie Fode, Jørgen Baltzer Petersen, Marianne Ingerslev Holt and Morten Høyer

    Citation: Radiation Oncology 2021 16:192

    Content type: Research

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  38. To determine the most appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with maxillary sinus cancer (MSC).

    Authors: Yasuo Kosugi, Michimasa Suzuki, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Yoichi Muramoto, Terufumi Kawamoto, Masaki Oshima, Naoto Shikama and Keisuke Sasai

    Citation: Radiation Oncology 2021 16:190

    Content type: Research

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  39. MR-guided online adaptive stereotactic body radiation therapy (SBRT) for prostate cancer aims to reduce toxicity by full compensation of interfractional uncertainties. However, the process of online adaptation...

    Authors: J. Schaule, M. Chamberlain, L. Wilke, M. Baumgartl, J. Krayenbühl, M. Zamburlini, M. Mayinger, N. Andratschke, S. Tanadini-Lang and M. Guckenberger

    Citation: Radiation Oncology 2021 16:189

    Content type: Research

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  40. In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potenti...

    Authors: Duncan den Boer, Johannes K. Veldman, Geertjan van Tienhoven, Arjan Bel and Zdenko van Kesteren

    Citation: Radiation Oncology 2021 16:188

    Content type: Research

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  41. Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radia...

    Authors: Lina Wang, Xiaohu Wang, Guangwen Zhang, Yan Ma, Qiuning Zhang, Zheng Li, Juntao Ran, Xiaoming Hou, Yichao Geng, Zheng Yang, Shuangwu Feng, Chengcheng Li and Xueshan Zhao

    Citation: Radiation Oncology 2021 16:187

    Content type: Review

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  42. To develop a risk model based on dosimetric metrics to predict local recurrence in nasopharyngeal carcinoma (NPC) patients treated with intensive modulated radiation therapy (IMRT).

    Authors: Wenjun Liao, Jinlan He, Zijian Liu, Maolang Tian, Jiangping Yang, Jiaqi Han and Jianghong Xiao

    Citation: Radiation Oncology 2021 16:186

    Content type: Research

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  43. To investigate the relationship between radiotherapy (RT) and the risk of cerebrovascular mortality (CVM) in head and neck cancer (HNC) survivors aged ≥ 65 years.

    Authors: Qing-Song He, Zhen-Ping Wang, Zhao-Jun Li, Ping Zhou, Chen-Lu Lian, San-Gang Wu and Si-Fang Chen

    Citation: Radiation Oncology 2021 16:185

    Content type: Research

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  44. The role of postoperative radiotherapy (PORT) in cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected non-small cell lung cancer (NSCLC) remains uncertain. The purpose of this pop...

    Authors: Xia Wang, Jiaqi Song, Jie Long, Zhimin Zeng and Anwen Liu

    Citation: Radiation Oncology 2021 16:184

    Content type: Research

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  45. Hybrid magnetic resonance (MR)-guided linear accelerators represent a new horizon in the field of radiation oncology. By harnessing the favorable combination of on-board MR-imaging with the possibility to dail...

    Authors: Francesco Cuccia, Filippo Alongi, Claus Belka, Luca Boldrini, Juliane Hörner-Rieber, Helen McNair, Michele Rigo, Maartje Schoenmakers, Maximilian Niyazi, Judith Slagter, Claudio Votta and Stefanie Corradini

    Citation: Radiation Oncology 2021 16:183

    Content type: Review

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