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  1. Total body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care in patients with acute myeloid leukemia (AML) but can cause long-term m...

    Authors: Isabella Gruber, Oliver Koelbl, Wolfgang Herr, Ernst Holler, Matthias Edinger and Daniel Wolff
    Citation: Radiation Oncology 2022 17:195
  2. Malignant melanoma constitutes an aggressive tumor of the skin, the pathogenesis of which is influenced by immunological processes. In this context, the influence of radiotherapy (RT) on inflammatory markers h...

    Authors: Michael Oertel, Katrin Borrmann, Andrea Baehr, Hans Theodor Eich and Burkhard Greve
    Citation: Radiation Oncology 2022 17:194
  3. Dose painting planning would be more complicated due to different levels of prescribed doses and more complex evaluation with conventional plan quality indices considering uniform dose prescription. Therefore,...

    Authors: Saman Moradi, Bijan Hashemi, Mohsen Bakhshandeh, Amin Banaei and Bahram Mofid
    Citation: Radiation Oncology 2022 17:193
  4. Authors: Johannes Kraft, Stefan Weick, Kathrin Breuer, Paul Lutyj, Klaus Bratengeier, Florian Exner, Anne Richter, Jörg Tamihardja, Dominik Lisowski, Bülent Polat and Michael Flentje
    Citation: Radiation Oncology 2022 17:192
  5. Esophagectomy is the standard adjuvant treatment for superficial esophageal squamous cell carcinoma (SESCC) following noncurative endoscopic submucosal dissection (ESD). However, recent reports have also shown...

    Authors: Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Takuya Kimoto, Shinsuke Nagasawa, Shou Watanabe, Shou Seri, Akito Asato, Atsushi Shiozaki, Hitoshi Fujiwara, Hirotaka Konishi, Osamu Dohi, Takeshi Ishikawa, Hany Elsaleh and Kei Yamada
    Citation: Radiation Oncology 2022 17:191
  6. Malignant peripheral nerve sheath tumors (MPNST) are sarcomas that arise from peripheral nerves. They generally have a poor prognosis which is exacerbated by high local recurrence rates. This case report discu...

    Authors: Edwin Chaharbakhshi, Joshua Hardham, Ramon Alfredo Siochi, Todd C. Tenenholz and Brock A. Lindsey
    Citation: Radiation Oncology 2022 17:190
  7. This study introduces innovative strategies, the doublet regimen of concurrent chemoradiotherapy, to ensure longer survival for locoregionally advanced nasopharyngeal carcinoma.

    Authors: Zhi-Qiang Wang, Xu-Dong Feng, Chun-Lei Ge, Yi Yang, Na Liang, Qing Ye, Yang Fu, Jian Wei, Yong Zhang and Rong-Qing Li
    Citation: Radiation Oncology 2022 17:189
  8. This study was designed to establish radiation pneumonitis (RP) prediction models using dosiomics and/or deep learning-based radiomics (DLR) features based on 3D dose distribution.

    Authors: Ying Huang, Aihui Feng, Yang Lin, Hengle Gu, Hua Chen, Hao Wang, Yan Shao, Yanhua Duan, Weihai Zhuo and Zhiyong Xu
    Citation: Radiation Oncology 2022 17:188
  9. Present studies on the efficacy and safety of curative chemoradiation therapy (CRT) with esophageal cancer reflect heterogenous results especially in elderly patients. The aim of this study was to evaluate the...

    Authors: Philipp Linde, Markus Mallmann, Anne Adams, Simone Wegen, Johannes Rosenbrock, Maike Trommer, Simone Marnitz, Christian Baues and Eren Celik
    Citation: Radiation Oncology 2022 17:187
  10. The Korean Radiation Oncology Group (KROG) 19 − 09 prospective cohort study aims to determine the effect of regional nodal irradiation on regional recurrence rates in ypN0 breast cancer patients. Dosimetric va...

    Authors: Myeongsoo Kim, Boram Park, Haksoo Kim, Yeon-Joo Kim, Dong Ju Choi, Weonkuu Chung, Yeon Joo Kim, Hyun Soo Shin, Jung Ho Im, Chang-Ok Suh, Jin Hee Kim, Boram Ha, Mi Young Kim, Jongmoo Park, Jeongshim Lee, Sung-Ja Ahn…
    Citation: Radiation Oncology 2022 17:186
  11. Monte Carlo simulation is considered as the most accurate method for dose calculation in radiotherapy. PRIMO is a Monte-Carlo program with a user-friendly graphical interface.

    Authors: Yang Li, Xingru Sun, Ying Liang, Yuchao Hu and Chenbin Liu
    Citation: Radiation Oncology 2022 17:185
  12. Definitive concurrent chemoradiotherapy (CCRT) is the standard treatment for locally advanced non-small cell lung cancer (LANSCLC) patients, but the treatment response and survival outcomes varied among these ...

    Authors: Nai-Bin Chen, Mai Xiong, Rui Zhou, Yin Zhou, Bo Qiu, Yi-Feng Luo, Su Zhou, Chu Chu, Qi-Wen Li, Bin Wang, Hai-Hang Jiang, Jin-Yu Guo, Kang-Qiang Peng, Chuan-Miao Xie and Hui Liu
    Citation: Radiation Oncology 2022 17:184
  13. The DNA damage response (DDR) is a mechanism that protects cells against radiation-induced oxidative DNA damage by causing cell cycle arrest and apoptosis. TP63 is a member of the tumour suppressor TP53 gene fami...

    Authors: Ken-ichi Kudo, Naohiro Tsuyama, Kento Nagata, Tatsuhiko Imaoka, Daisuke Iizuka, Misaki Sugai-Takahashi, Moe Muramatsu and Akira Sakai
    Citation: Radiation Oncology 2022 17:183
  14. Artificial intelligence (AI) algorithms are capable of automatically detecting contouring boundaries in medical images. However, the algorithms impact on clinical practice of cervical cancer are unclear. We ai...

    Authors: Shihong Nie, Yuanfeng Wei, Fen Zhao, Ya Dong, Yan Chen, Qiaoqi Li, Wei Du, Xin Li, Xi Yang and Zhiping Li
    Citation: Radiation Oncology 2022 17:182
  15. Tumor-infiltrating lymphocytes (TILs) are associated with locoregional control (LRC) in head-and-neck squamous cell carcinoma (HNSCC) patients undergoing (chemo)radiotherapy. As immunosenescence results in red...

    Authors: Alexander Rühle, Jovan Todorovic, Simon S. K. Spohn, Eleni Gkika, Christoph Becker, Andreas Knopf, Constantinos Zamboglou, Tanja Sprave, Martin Werner, Anca-Ligia Grosu, Gian Kayser and Nils H. Nicolay
    Citation: Radiation Oncology 2022 17:181
  16. The aim of this work was to determine whether patients with intermediate-risk head and neck squamous cell carcinoma (HNSCC) can benefit from postoperative chemoradiotherapy (POCRT).

    Authors: Zhi-Qiao Liu, Pu-Yun OuYang, Bao-Yu Zhang, En-Ni Chen, Su-Ming Xiao, Shan-Shan Yang, Zhong-Yuan Yang and Fang-Yun Xie
    Citation: Radiation Oncology 2022 17:180
  17. This systematic review aims to synthesise the outcomes of different strategies of incorporating functional biological markers in the radiation therapy plans of patients with glioblastoma to support clinicians ...

    Authors: John T Ryan, Masao Nakayama, Ian Gleeson, Liam Mannion, Moshi Geso, Jennifer Kelly, Sweet Ping Ng and Nicholas Hardcastle
    Citation: Radiation Oncology 2022 17:178
  18. Based on a previous study on the feasibility of TomoEQA, an exit detector-based patient-specific pre-treatment quality assurance (QA) method for helical tomotherapy, an in-depth clinical evaluation was conducted.

    Authors: Changhwan Kim, Min Cheol Han, Young Kyu Lee, Han-Back Shin, Hojin Kim and Jin Sung Kim
    Citation: Radiation Oncology 2022 17:177
  19. To assess the effectiveness and toxicity of radiation dose escalation for locally advanced nasopharyngeal carcinoma (LA-NPC) in patients with local and/or regional residual lesion(s) after standard treatment.

    Authors: Ting Jin, Nan-Fang Liu, Qi-Feng Jin, Yong-Hong Hua and Xiao-Zhong Chen
    Citation: Radiation Oncology 2022 17:176
  20. Radiotherapy is one of the effective ways to treat glioblastoma multiforme (GBM). We aimed to explore the prognostic difference between external beam radiotherapy (EBRT) and EBRT combined with brachytherapy (E...

    Authors: Kai Yang, Yan Ma, Guo Chen, Shaojie Zeng, Ting Guo and Zelong Yang
    Citation: Radiation Oncology 2022 17:174
  21. Localized pancreatic adenocarcinoma carries a poor prognosis even after aggressive therapy. Up to 40% of patients may develop locoregional disease as the first site of failure. As such, there may be a role for...

    Authors: Abhinav V. Reddy, Colin S. Hill, Lei Zheng, Jin He and Amol K. Narang
    Citation: Radiation Oncology 2022 17:173
  22. Primary central nervous system lymphoma (PCNSL) is a rare and aggressive malignancy. Although potentially curable, its prognosis remains dismal. Its treatment is based on high-doses of methotrexate (HD-MTX) an...

    Authors: Luís Alberto de Pádua Covas Lage, Vinícius Araújo Soares, Thales Dalessandro Meneguin, Hebert Fabrício Culler, Cadiele Oliana Reichert, Mayara D’Auria Jacomassi, Diego Gomes Cândido Reis, Maria Cláudia Nogueira Zerbini, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira
    Citation: Radiation Oncology 2022 17:171
  23. To save time and have more consistent contours, fully automatic segmentation of targets and organs at risk (OAR) is a valuable asset in radiotherapy. Though current deep learning (DL) based models are on par w...

    Authors: Robert Poel, Elias Rüfenacht, Ekin Ermis, Michael Müller, Michael K. Fix, Daniel M. Aebersold, Peter Manser and Mauricio Reyes
    Citation: Radiation Oncology 2022 17:170
  24. To introduce and compare multiple biological effectiveness guided (BG) proton plan optimization strategies minimizing variable relative biological effectiveness (RBE) induced dose burden in organs at risk (OAR...

    Authors: Christian Hahn, Lena Heuchel, Jakob Ödén, Erik Traneus, Jörg Wulff, Sandija Plaude, Beate Timmermann, Christian Bäumer and Armin Lühr
    Citation: Radiation Oncology 2022 17:169
  25. The ESTRO-ACROP Consensus Guideline (EACG) recommends implant excluded clinical target volume (CTVp) definitions for post-mastectomy radiation therapy after implant-based immediate breast reconstruction (IBR)....

    Authors: Evren Ozan Göksel, Evrim Tezcanli, Alptekin Arifoğlu, Halil Küçücük, Öznur Şenkesen, Ufuk Abacıoğlu, Işık Aslay and Meriç Şengöz
    Citation: Radiation Oncology 2022 17:168
  26. Dose escalation for positive node maybe improve the regional control of patients with node-positive cervical cancer, but the optimal dose for nodes of different sizes remains controversial. The purpose of this...

    Authors: Xiaojuan Lv, Huiting Rao, Tao Feng, Chufan Wu and Hanmei Lou
    Citation: Radiation Oncology 2022 17:167
  27. Script-based planning and knowledge-based planning are two kinds of automatic planning solutions. Hybrid automatic planning may integrate the advantages of both solutions and provide a more robust automatic pl...

    Authors: Jiyou Peng, Lei Yu, Fan Xia, Kang Zhang, Zhen Zhang, Jiazhou Wang and Weigang Hu
    Citation: Radiation Oncology 2022 17:166
  28. The first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new treatment (second surgical operation or salvage radiotherapy) in case of recurr...

    Authors: Thomas Charleux, Véronique Vendrely, Aymeri Huchet, Renaud Trouette, Amandine Ferrière, Antoine Tabarin, Vincent Jecko, Hugues Loiseau and Charles Dupin
    Citation: Radiation Oncology 2022 17:165
  29. The aim of this study was to investigate the result of hyperbaric oxygen therapy (HBOT) in women with treated gynaecological malignancies who suffer from late radiation-induced tissue toxicity (LRITT). Moreove...

    Authors: Nadine I. Geldof, Rob A. van Hulst, Milan L. Ridderikhof and David N. Teguh
    Citation: Radiation Oncology 2022 17:164
  30. Accurate surrogate parameters for radio resistance are warranted for individualized radiotherapy (RT) concepts in prostate cancer (PCa). The purpose of this study was to assess intertumoral heterogeneity in te...

    Authors: Ioana M. Marinescu, Manuel Rogg, Simon Spohn, Moritz von Büren, Marius Kamps, Cordula A. Jilg, Elena Fountzila, Kyriaki Papadopoulou, Lara Ceci, Alisa Bettermann, Juri Ruf, Matthias Benndorf, Sonja Adebahr, Daniel Zips, Anca L. Grosu, Christoph Schell…
    Citation: Radiation Oncology 2022 17:163
  31. To assess the impact of systematic setup and range uncertainties for robustly optimized (RO) intensity modulated proton therapy (IMPT) and volumetric modulated arc therapy (VMAT) plans in patients with localiz...

    Authors: Michael P. Butkus, Nellie Brovold, Tejan Diwanji, Yihang Xu, Mariluz De Ornelas, Alan Dal Pra, Matt Abramowitz, Alan Pollack and Nesrin Dogan
    Citation: Radiation Oncology 2022 17:162
  32. The standard therapy for brain metastasis was surgery combined with whole brain radiotherapy (WBRT). The latter is however, associated with important neurocognitive toxicity. To reduce this toxicity, postopera...

    Authors: Marie Cantaloube, Mohamed Boucekine, Anne Balossier, Xavier Muracciole, Mickael Meyer, Christine Delsanti, Romain Carron, Yassine Mohamed Beltaifa, Domnique Figarella-Branger, Jean Regis and Laetitia Padovani
    Citation: Radiation Oncology 2022 17:160
  33. Soft tissue sarcomas (STS) represent a diverse group of rare malignant tumors. Currently, five to six weeks of preoperative radiotherapy (RT) combined with surgery constitute the mainstay of therapy for local...

    Authors: Siyer Roohani, Felix Ehret, Marta Kobus, Anne Flörcken, Sven Märdian, Jana Käthe Striefler, Daniel Rau, Robert Öllinger, Armin Jarosch, Volker Budach and David Kaul
    Citation: Radiation Oncology 2022 17:159
  34. Many patients with incurable esophageal cancer (ECa) present with dysphagia as their predominant symptom. Currently there is no consensus on how best to initially manage this scenario with multiple therapeutic...

    Authors: Swetha Sridharan, Fiona Day, Jasmin Loh, James Lynam, Joanne Smart, Brandan Holt, Hiren Mandaliya, Anthony Bonaventura, Mahesh Kumar and Jarad Martin
    Citation: Radiation Oncology 2022 17:158
  35. Online adaptive stereotactic radiotherapy allows for improved target and organ at risk (OAR) delineation and inter-fraction motion management via daily adaptive planning. The use of adaptive SBRT for the treat...

    Authors: Minsol Kim, Joshua P. Schiff, Alex Price, Eric Laugeman, Pamela P. Samson, Hyun Kim, Shahed N. Badiyan and Lauren E. Henke
    Citation: Radiation Oncology 2022 17:157
  36. Stereotactic body radiotherapy (SBRT) is a promising approach in treating painful bone metastases. However, the superiority of SBRT over conventional external beam radiotherapy (cEBRT) remains controversial. T...

    Authors: Kei Ito, Tetsuo Saito, Naoki Nakamura, Nobuki Imano and Peter Hoskin
    Citation: Radiation Oncology 2022 17:156
  37. To compare the dosimetric profiles of volumetric modulated arc therapy (VMAT) plans using the fast-rotating O-ring linac (the Halcyon system) based on a dual-layer stacked multi-leaf collimator and helical tom...

    Authors: Sang Gyu Ju, Yong Chan Ahn, Yeong-bi Kim, Jin Man Kim, Dong Yeol Kwon, Byoung Suk Park and Kyungmi Yang
    Citation: Radiation Oncology 2022 17:155
  38. The CyberKnife Xsight lung-tracking system (XLTS) provides an alternative to fiducial-based target-tracking systems (FTTS) for non-small-cell lung cancer (NSCLC) patients without invasive fiducial insertion pr...

    Authors: Thomas J. Klein, Suki Gill, Martin A. Ebert, Garry Grogan, Warwick Smith, Zaid Alkhatib, John Geraghty, Alison J. D. Scott, Alan Brown and Pejman Rowshanfarzad
    Citation: Radiation Oncology 2022 17:154
  39. Accompanied by the demographic change, the number of octogenarian cancer patients with bone metastases will increase in the future. Palliative radiotherapy constitutes an effective analgesic treatment; however...

    Authors: Alexander Rühle, Verlaine Ange Nya Yompang, Simon K. B. Spohn, Raluca Stoian, Constantinos Zamboglou, Eleni Gkika, Anca-Ligia Grosu, Nils H. Nicolay and Tanja Sprave
    Citation: Radiation Oncology 2022 17:153
  40. Fast and accurate outlining of the organs at risk (OARs) and high-risk clinical tumor volume (HRCTV) is especially important in high-dose-rate brachytherapy due to the highly time-intensive online treatment pl...

    Authors: Zhen Li, Qingyuan Zhu, Lihua Zhang, Xiaojing Yang, Zhaobin Li and Jie Fu
    Citation: Radiation Oncology 2022 17:152
  41. We developed a novel concept, equivalent uniform length (EUL), to describe the relationship between the generalized equivalent uniform dose (EUD) and the geometric anatomy around a tumor target. By correlating...

    Authors: Cheng Tao, Bo Liu, Chengqiang Li, Jian Zhu, Yong Yin and Jie Lu
    Citation: Radiation Oncology 2022 17:151
  42. To investigate the performance of a narrow-scope knowledge-based RapidPlan (RP) model for optimisation of intensity-modulated proton therapy (IMPT) and volumetric modulated arc therapy (VMAT) plans applied to ...

    Authors: Davide Franceschini, Luca Cozzi, Antonella Fogliata, Beatrice Marini, Luciana Di Cristina, Luca Dominici, Ruggero Spoto, Ciro Franzese, Pierina Navarria, Tiziana Comito, Giacomo Reggiori, Stefano Tomatis and Marta Scorsetti
    Citation: Radiation Oncology 2022 17:150
  43. Authors: Sebastian Marschner, Manasi Datar, Aurélie Gaasch, Zhoubing Xu, Sasa Grbic, Guillaume Chabin, Bernhard Geiger, Julian Rosenman, Stefanie Corradini, Maximilian Niyazi, Tobias Heimann, Christian Möhler, Fernando Vega, Claus Belka and Christian Thieke
    Citation: Radiation Oncology 2022 17:149

    The original article was published in Radiation Oncology 2022 17:129

  44. The outcome of patients with T4 esophageal squamous cell carcinoma (ESCC) is extremely poor. Two distinct therapeutic options are currently available for T4 esophageal cancers: neochemoradiotherapy followed by...

    Authors: Tian Zhang, Zhoubo Guo, Xi Chen, Jie Dong, Hongjing Jiang, Peng Tang, Ping Wang, Dong Qian, Wencheng Zhang and Qingsong Pang
    Citation: Radiation Oncology 2022 17:148
  45. This study investigated whether radiomic features can improve the prediction accuracy for tumor recurrence over clinicopathological features and if these features can be used to identify high-risk patients req...

    Authors: Chae Jung Park, Seo Hee Choi, Jihwan Eom, Hwa Kyung Byun, Sung Soo Ahn, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee, Yae Won Park and Hong In Yoon
    Citation: Radiation Oncology 2022 17:147
  46. Magnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic t...

    Authors: Berend J. Slotman, Mary Ann Clark, Enis Özyar, Myungsoo Kim, Jun Itami, Agnès Tallet, Jürgen Debus, Raphael Pfeffer, PierCarlo Gentile, Yukihiro Hama, Nicolaus Andratschke, Olivier Riou, Philip Camilleri, Claus Belka, Magali Quivrin, BoKyong Kim…
    Citation: Radiation Oncology 2022 17:146

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