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  1. Research

    A phase II study of preoperative chemoradiation with tegafur-uracil plus leucovorin for locally advanced rectal cancer with pharmacogenetic analysis

    This study aimed to evaluate the efficacy of a high dose of oral tegafur-uracil (400 mg/m2) plus leucovorin with preoperative chemoradiation of locally advanced rectal cancer and to explore the impact of polymorp...

    Sun Young Kim, Ji Yeon Baek, Jae Hwan Oh, Sung Chan Park, Dae Kyung Sohn, Min Ju Kim, Hee Jin Chang, Sun-Young Kong and Dae Yong Kim

    Radiation Oncology 2017 12:62

    Published on: 27 March 2017

  2. Research

    Tumor motion changes in stereotactic body radiotherapy for liver tumors: an evaluation based on four-dimensional cone-beam computed tomography and fiducial markers

    For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning...

    Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya and Fujio Araki

    Radiation Oncology 2017 12:61

    Published on: 23 March 2017

  3. Research

    The benefit of adjuvant radiotherapy after breast conserving surgery in older patients with low risk breast cancer- a meta-analysis of randomized trials

    It is currently unclear whether patients with low risk breast cancer receiving adjuvant endocrine therapy need adjuvant radiation therapy after breast conserving surgery. The data of randomized trials are avai...

    Christiane Matuschek, Edwin Bölke, Jan Haussmann, Svjetlana Mohrmann, Carolin Nestle-Krämling, Peter Arne Gerber, Stefanie Corradini, Klaus Orth, Kai Kammers and Wilfried Budach

    Radiation Oncology 2017 12:60

    Published on: 23 March 2017

  4. Research

    Radiation dose escalation based on FDG-PET driven dose painting by numbers in oropharyngeal squamous cell carcinoma: a dosimetric comparison between TomoTherapy-HA and RapidArc

    Validation of dose escalation through FDG-PET dose painting (DP) for oropharyngeal squamous cell carcinoma (SCC) requires randomized clinical trials with large sample size, potentially involving different trea...

    Sarah Differding, Edmond Sterpin, Nicolas Hermand, Bianca Vanstraelen, Sandra Nuyts, Nathalie de Patoul, Jean-Marc Denis, John Aldo Lee and Vincent Grégoire

    Radiation Oncology 2017 12:59

    Published on: 23 March 2017

  5. Research

    Considerable interobserver variation in delineation of pancreatic cancer on 3DCT and 4DCT: a multi-institutional study

    The delineation of pancreatic tumors on CT is challenging. In this study, we quantified the interobserver variation for pancreatic tumor delineation on 3DCT as well as on 4DCT.

    Eva Versteijne, Oliver J. Gurney-Champion, Astrid van der Horst, Eelco Lens, M. Willemijn Kolff, Jeroen Buijsen, Gati Ebrahimi, Karen J. Neelis, Coen R. N. Rasch, Jaap Stoker, Marcel van Herk, Arjan Bel and Geertjan van Tienhoven

    Radiation Oncology 2017 12:58

    Published on: 23 March 2017

  6. Review

    Influence of autophagy on the efficacy of radiotherapy

    Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-sur...

    Shing Yau Tam, Vincent Wing Cheung Wu and Helen Ka Wai Law

    Radiation Oncology 2017 12:57

    Published on: 21 March 2017

  7. Research

    An appraisal of analytical tools used in predicting clinical outcomes following radiation therapy treatment of men with prostate cancer: a systematic review

    Prostate cancer can be treated with several different modalities, including radiation treatment. Various prognostic tools have been developed to aid decision making by providing estimates of the probability of...

    Elspeth Raymond, Michael E. O’Callaghan, Jared Campbell, Andrew D. Vincent, Kerri Beckmann, David Roder, Sue Evans, John McNeil, Jeremy Millar, John Zalcberg, Martin Borg and Kim Moretti

    Radiation Oncology 2017 12:56

    Published on: 21 March 2017

  8. Research

    A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy

    To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the ...

    Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin and An-Cheng Shiau

    Radiation Oncology 2017 12:55

    Published on: 20 March 2017

  9. Research

    Using field size factors to characterize the in-air fluence of a proton machine with a range shifter

    The range shifter (RS) is used to treat shallow tumors for a proton pencil beam scanning system (PBS). Adding RS certainly complicates the commissioning of the treatment planning system (TPS) because the spot ...

    Jiajian Shen, Jarrod M. Lentz, Yanle Hu, Wei Liu, Danairis Hernandez Morales, Joshua B. Stoker and Martin Bues

    Radiation Oncology 2017 12:52

    Published on: 14 March 2017

  10. Research

    Prostate cancer treated with brachytherapy; an exploratory study of dose-dependent biomarkers and quality of life

    Low-dose-rate permanent prostate brachytherapy (PPB) is an attractive treatment option for patients with localised prostate cancer with excellent outcomes. As standard CT-based post-implant dosimetry often cor...

    Sarah O. S. Osman, Simon Horn, Darren Brady, Stephen J. McMahon, Ahamed B. Mohamed Yoosuf, Darren Mitchell, Karen Crowther, Ciara A. Lyons, Alan R. Hounsell, Kevin M. Prise, Conor K. McGarry, Suneil Jain and Joe M. O’Sullivan

    Radiation Oncology 2017 12:53

    Published on: 14 March 2017

  11. Research

    Hypo- or conventionally fractionated radiotherapy combined with chemotherapy in patients with limited stage small cell lung cancer

    Previous data from our institution showed that hypofractionated thoracic radiotherapy (HypoTRT) with concurrent etoposide/platinum chemotherapy yielded favorable survival in patients with limited-stage small c...

    Jing Zhang, Min Fan, Di Liu, Kuai-Le Zhao, Kai-Liang Wu, Wei-Xin Zhao, Zheng-Fei Zhu and Xiao-Long Fu

    Radiation Oncology 2017 12:51

    Published on: 11 March 2017

  12. Research

    The effect of bowel preparation regime on interfraction rectal filling variation during image guided radiotherapy for prostate cancer

    This study aimed to investigate the tolerability and impact of milk of magnesia (MoM) on interfraction rectal filling during prostate cancer radiotherapy.

    Ali Hosni, Tara Rosewall, Timothy Craig, Vickie Kong, Andrew Bayley, Alejandro Berlin, Robert Bristow, Charles Catton, Padraig Warde and Peter Chung

    Radiation Oncology 2017 12:50

    Published on: 9 March 2017

  13. Research

    Salvage prostate re-irradiation using high-dose-rate brachytherapy or focal stereotactic body radiotherapy for local recurrence after definitive radiation therapy

    Optimal management of locally recurrent prostate cancer after definitive radiation therapy is still challenging. With the development of highly accurate radiotherapy devices, prostate salvage re-irradiation mi...

    Aurélie Mbeutcha, Laurent Chauveinc, Pierre-Yves Bondiau, Marie-Eve Chand, Matthieu Durand, Daniel Chevallier, Jean Amiel, Daniel Lam Cham Kee and Jean-Michel Hannoun-Lévi

    Radiation Oncology 2017 12:49

    Published on: 9 March 2017

  14. Research

    A phase II study of concurrent chemoradiotherapy combined with a weekly paclitaxel and 5-fluorouracil regimen to treat patients with advanced oesophageal carcinoma

    A phase II study was performed to investigate the safety and efficacy of weekly doses of combined paclitaxel and 5-fluorouracil (5-FU) with concurrent radiation therapy, followed by 2 cycles of consolidation c...

    Yi Xia, Yun-hai Li, Yun Chen, Jun-hua Zhang, Qi Liu, Jia-ying Deng, Ta-shan Ai, Han-ting Zhu, Jian-hong Fan, Harun Badakhshi and Kuai-le Zhao

    Radiation Oncology 2017 12:47

    Published on: 7 March 2017

  15. Research

    Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer

    Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy. This study investigated the treatment efficacy and toxicity of neoadjuva...

    Chun-Ming Huang, Ming-Yii Huang, Cheng-Jen Ma, Yung –Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Chih-Jen Huang and Jaw-Yuan Wang

    Radiation Oncology 2017 12:48

    Published on: 7 March 2017

  16. Research

    Reducing radiation dose to normal brain through a risk adapted dose reduction protocol for patients with favourable subtype anaplastic glioma

    In patients with isocitrate dehydrogenase (IDH) mutated anaplastic glioma determine the dosimetric benefits of delivering radiation therapy using a PET guided integrated boost IMRT technique (ib-IMRT) compared...

    M. Back, M. LeMottee, C. Crasta, D. Bailey, H. Wheeler, L. Guo and T. Eade

    Radiation Oncology 2017 12:46

    Published on: 2 March 2017

  17. Research

    Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers

    Current adaptive and dose escalating radiotherapy for muscle invasive bladder cancer requires knowledge of both inter-fractional and intra-fractional motion of the bladder wall involved. The purpose of this st...

    Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru and Hiroki Shirato

    Radiation Oncology 2017 12:44

    Published on: 1 March 2017

  18. Study protocol

    Do selective radiation dose escalation and tumour hypoxia status impact the loco-regional tumour control after radio-chemotherapy of head & neck tumours? The ESCALOX protocol

    Standard of care primary treatment of carcinoma of locally advanced squamous cell head and neck cancer (LAHNSCC) consists of platinum-based concomitant chemo-irradiation. Despite progress in the treatment of L...

    Steffi U. Pigorsch, Jan J. Wilkens, Severin Kampfer, Victoria Kehl, Alexander Hapfelmeier, Christian Schläger, Henning Bier, Markus Schwaiger and Stephanie E. Combs

    Radiation Oncology 2017 12:45

    Published on: 1 March 2017

  19. Research

    Clinical outcomes of gastrointestinal brain metastases treated with radiotherapy

    Brain metastases of gastrointestinal origin are a rare occurrence. Radiation therapy (RT) in the form of stereotactic radiosurgery (SRS) or whole brain radiation therapy (WBRT) is an effective established trea...

    Samrat M. Sanghvi, Jonathan W. Lischalk, Ling Cai, Sean Collins, Mani Nair, Brain Collins and Keith Unger

    Radiation Oncology 2017 12:43

    Published on: 28 February 2017

  20. Research

    Real-time in vivo rectal wall dosimetry using MOSkin detectors during linac based stereotactic radiotherapy with rectal displacement

    MOSFET dosimetry is a method that has been used to measure in-vivo doses during brachytherapy treatments and during linac based radiotherapy treatment. Rectal displacement devices (RDDs) allow for safe dose es...

    Kimberley Legge, Peter B. Greer, Daryl J. O’Connor, Lee Wilton, Matthew Richardson, Perry Hunter, Alex Wilfert, Jarad Martin, Anatoly Rosenfeld and Dean Cutajar

    Radiation Oncology 2017 12:41

    Published on: 27 February 2017

  21. Research

    A comparative study of dose distribution of PBT, 3D-CRT and IMRT for pediatric brain tumors

    It was reported that proton beam therapy (PBT) reduced the normal brain dose compared with X-ray therapy for pediatric brain tumors. We considered whether there was not the condition that PBT was more disadvan...

    Daichi Takizawa, Masashi Mizumoto, Tetsuya Yamamoto, Yoshiko Oshiro, Hiroko Fukushima, Takashi Fukushima, Toshiyuki Terunuma, Toshiyuki Okumura, Koji Tsuboi and Hideyuki Sakurai

    Radiation Oncology 2017 12:40

    Published on: 22 February 2017

  22. Research

    Definitive salvage radiation therapy and chemoradiation therapy for lymph node oligo-recurrence of esophageal cancer: a Japanese multi-institutional study of 237 patients

    This study evaluated the treatment results of lymph node (LN) oligo-recurrence in esophageal cancer patients treated with salvage radiotherapy (RT) in a multi-institutional retrospective study.

    Hideomi Yamashita, Keiichi Jingu, Yuzuru Niibe, Kuniaki Katsui, Toshihiko Matsumoto, Tomohiro Nishina and Atsuro Terahara

    Radiation Oncology 2017 12:38

    Published on: 20 February 2017

  23. Research

    Concurrent chemoradiotherapy with conventional fractionated radiotherapy and low-dose daily cisplatin plus weekly docetaxel for T2N0 glottic cancer

    To assess the efficacy of concurrent chemoradiotherapy (CCRT) with daily low-dose cisplatin (CDDP) plus weekly docetaxel (DTX) for patients with T2N0 glottic cancer.

    Jun-ichi Saitoh, Katsuyuki Shirai, Masumi Imaeda, Atsushi Musha, Takanori Abe, Masato Shino, Yukihiro Takayasu, Katsumasa Takahashi, Kazuaki Chikamatsu and Takashi Nakano

    Radiation Oncology 2017 12:39

    Published on: 20 February 2017

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