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  1. Research

    Quality assurance of the SCOPE 1 trial in oesophageal radiotherapy

    SCOPE 1 was the first UK based multi-centre trial involving radiotherapy of the oesophagus. A comprehensive radiotherapy trials quality assurance programme was launched with two main aims:


    Lucy Wills, Rhydian Maggs, Geraint Lewis, Gareth Jones, Lisette Nixon, John Staffurth and Tom Crosby

    Radiation Oncology 2017 12:179

    Published on: 15 November 2017

  2. Research

    Conventional fractionation should not be the standard of care for T2 glottic cancer

    The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorte...

    Lynne M. Dixon, Catriona M. Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J. Sykes, David Thomson and Nicholas J. Slevin

    Radiation Oncology 2017 12:178

    Published on: 14 November 2017

  3. Research

    Early motor function after local treatment of brain metastases in the motor cortex region with stereotactic radiotherapy/radiosurgery or microsurgical resection: a retrospective study of two consecutive cohorts

    We compared the functional outcome and influential factors of two standard treatment modalities for central cerebral metastases: electrophysiological-controlled microsurgical resection (MSR) and stereotactic r...

    Bogdan Pintea, Brigitta Baumert, Thomas Mehari Kinfe, Konstantinos Gousias, Yaroslav Parpaley and Jan Patrick Boström

    Radiation Oncology 2017 12:177

    Published on: 13 November 2017

  4. Research

    Detection level and pattern of positive lesions using PSMA PET/CT for staging prior to radiation therapy

    To determine the potential role of 68Ga-PSMA positron emission tomography/computed tomography (PET/CT) in radiotherapy (RT) planning for prostate cancer (PCa).

    Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Alexander Buchner, Christian Stief, Paul Rogowski, Maximilian Niyazi, Chukwuka Eze, Minglun Li, Peter Bartenstein, Claus Belka and Ute Ganswindt

    Radiation Oncology 2017 12:176

    Published on: 10 November 2017

  5. Research

    Potential dosimetric benefits of adaptive tumor tracking over the internal target volume concept for stereotactic body radiation therapy of pancreatic cancer

    Radiotherapy for pancreatic cancer has two major challenges: (I) the tumor is adjacent to several critical organs and, (II) the mobility of both, the tumor and its surrounding organs at risk (OARs). A treatmen...

    Konstantina Karava, Stefanie Ehrbar, Oliver Riesterer, Johannes Roesch, Stefan Glatz, Stephan Klöck, Matthias Guckenberger and Stephanie Tanadini-Lang

    Radiation Oncology 2017 12:175

    Published on: 9 November 2017

  6. Research

    Carbon ion radiotherapy: impact of tumor differentiation on local control in experimental prostate carcinomas

    To summarize the research activities of the “clinical research group heavy ion therapy”, funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypo...

    Christin Glowa, Peter Peschke, Stephan Brons, Oliver C. Neels, Klaus Kopka, Jürgen Debus and Christian P. Karger

    Radiation Oncology 2017 12:174

    Published on: 9 November 2017

  7. Correction

    Correction to: Improved plan quality with automated radiotherapy planning for whole brain with hippocampus sparing: a comparison to the RTOG 0933 trial

    In the original publication [1] figure legends 2 and 4 have been swapped. The original article was updated to rectify this error.

    J. Krayenbuehl, M. Di Martino, M. Guckenberger and N. Andratschke

    Radiation Oncology 2017 12:173

    Published on: 8 November 2017

    The original article was published in Radiation Oncology 2017 12:161

  8. Research

    Quantitative assessment of radiation dose and fractionation effects on normal tissue by utilizing a novel lung fibrosis index model

    Normal lung tissue tolerance constitutes a limiting factor in delivering the required dose of radiotherapy to cure thoracic and chest wall malignancies. Radiation-induced lung fibrosis (RILF) is considered a c...

    Cheng Zhou, Bleddyn Jones, Mahmoud Moustafa, Christian Schwager, Julia Bauer, Bing Yang, Liji Cao, Min Jia, Andrea Mairani, Ming Chen, Longhua Chen, Juergen Debus and Amir Abdollahi

    Radiation Oncology 2017 12:172

    Published on: 7 November 2017

  9. Research

    Normal lung sparing Tomotherapy technique in stage III lung cancer

    Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for s...

    Chae-Seon Hong, Sang Gyu Ju, Yong Chan Ahn, Gyu Sang Yoo, Jae Myoung Noh, Dongryul Oh, Kwangzoo Chung, Hongryull Pyo and Kwanghyun Jo

    Radiation Oncology 2017 12:167

    Published on: 6 November 2017

  10. Review

    Management of organ motion in scanned ion beam therapy

    Scanned ion beam therapy has special demands for treatment of intra-fractionally moving tumors such as lesions in lung or liver. Interplay effects between beam and organ motion can in those settings lead to un...

    Christoph Bert and Klaus Herfarth

    Radiation Oncology 2017 12:170

    Published on: 6 November 2017

  11. Research

    First intraindividual comparison of contrast-enhanced MRI, FET- and DOTATOC- PET in patients with intracranial meningiomas

    For irradiation treatment planning of meningiomas the use of PET-scans is well established. The most frequently used tracers are either based on amino acids or the somatostatin receptor ligand DOTATOC. Since u...

    Jan Oliver Dittmar, Clemens Kratochwil, Anne Dittmar, Thomas Welzel, Daniel Habermehl, Stefan Rieken, Frederik L. Giesel, Uwe Haberkorn, Jürgen Debus and Stephanie E. Combs

    Radiation Oncology 2017 12:169

    Published on: 6 November 2017

  12. Research

    An investigation into the range dependence of target delineation strategies for stereotactic lung radiotherapy

    The “gold standard” approach for defining an internal target volume (ITV) is using 10 gross tumor volume (GTV) phases delineated over the course of one respiratory cycle. However, different sites have adopted ...

    Dennis J. Mohatt, John M. Keim, Mathew C. Greene, Ami Patel-Yadav, Jorge A. Gomez and Harish K. Malhotra

    Radiation Oncology 2017 12:166

    Published on: 3 November 2017

  13. Research

    Temporal and spatial dose distribution of radiation pneumonitis after concurrent radiochemotherapy in stage III non-small cell cancer patients

    Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are...

    Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer and Christoph Henkenberens

    Radiation Oncology 2017 12:165

    Published on: 2 November 2017

  14. Research

    Stereotactic body radiation therapy (SBRT) for definitive treatment and as a bridge to liver transplantation in early stage inoperable Hepatocellular carcinoma

    Stereotactic body radiotherapy (SBRT) is an emerging modality for definitive treatment of Hepatocellular carcinoma (HCC).

    Assaf Moore, Michal Cohen-Naftaly, Anna Tobar, Yulia Kundel, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eytan Mor, Michal Sarfaty, Dimitri Bragilovski, Ran Ben Hur, Noa Gordon, Salomon M. Stemmer and Aaron M. Allen

    Radiation Oncology 2017 12:163

    Published on: 19 October 2017

  15. Research

    Five-fraction SBRT for ultra-central NSCLC in-field recurrences following high-dose conventional radiation

    Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body r...

    Michael C. Repka, Nima Aghdam, Shaan K. Kataria, Lloyd Campbell, Simeng Suy, Sean P. Collins, Eric Anderson, Jonathan W. Lischalk and Brian T. Collins

    Radiation Oncology 2017 12:162

    Published on: 19 October 2017

  16. Research

    Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis

    The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of...

    Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa and Yasutaka Nakano

    Radiation Oncology 2017 12:160

    Published on: 2 October 2017

  17. Research

    Improved plan quality with automated radiotherapy planning for whole brain with hippocampus sparing: a comparison to the RTOG 0933 trial

    Whole-brain radiation therapy (WBRT) with hippocampus sparing (HS) has been investigated by the radiation oncology working group (RTOG) 0933 trial for patients with multiple brain metastases. They showed a dec...

    J. Krayenbuehl, M. Di Martino, M. Guckenberger and N. Andratschke

    Radiation Oncology 2017 12:161

    Published on: 2 October 2017

    The Correction to this article has been published in Radiation Oncology 2017 12:173

  18. Research

    CT imaging features associated with recurrence in non-small cell lung cancer patients after stereotactic body radiotherapy

    Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investi...

    Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G. Moros, Matthew B. Schabath, Zhaoxiang Ye, Robert J. Gillies and Thomas J. Dilling

    Radiation Oncology 2017 12:158

    Published on: 25 September 2017

  19. Research

    Comparative study of the effects of different radiation qualities on normal human breast cells

    As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt

    Radiation Oncology 2017 12:159

    Published on: 25 September 2017

  20. Research

    Combined high dose radiation and pazopanib in metastatic renal cell carcinoma: a phase I dose escalation trial

    The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.

    Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer and Piet Ost

    Radiation Oncology 2017 12:157

    Published on: 22 September 2017

  21. Research

    Comparison of volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with conventional radiotherapy in preoperative chemoradiation for rectal cancers: a propensity score case-matched analysis

    The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy ...

    Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe and Keiichi Nakagawa

    Radiation Oncology 2017 12:156

    Published on: 21 September 2017

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