Skip to main content
Download PDF

Treatment outcomes of surgery followed by short-course every other day radiotherapy in keloid

Radiation Oncology volume 19, Article number: 91 (2024) Cite this article

Abstract

Background

Postoperative radiotherapy can significantly reduce keloid recurrence. However, consensus on the optimal radiotherapy dose and treatment schedule remains elusive. This study aims to evaluate the effectiveness of surgery followed by a short-course of radiotherapy administered every other day for keloid treatment.

Materials/Methods

We conducted a retrospective analysis of 498 patients with keloids treated at our institution between January 2010 and December 2017. All patients underwent electron beam irradiation at a dose of 16 Gy, delivered in four fractions every other day, starting within 24 h post-surgery. The primary endpoint of the study was the local control rate.

Results

A total of 130 (26.5%) keloids recurred after a median follow-up of 68.1months (42.6-129.9 months). The local control rates at 1 year, 3 years and 5 years for all patients were 89.5%, 82.5% and 81%, respectively. The highest recurrence rate was observed in keloids located in the chest region (50.8%), followed by the suprapubic (47.8%), head and neck (38.8%), limbs (33.3%) and ear (14%). Both multivariate and univariate analyses identified the presence of pain and or pruritus as an independently prognostic factor for keloid recurrence (p<0.0001). The local control rates at 1-year, 3-years and 5-years for patients with or without symptom of pain or pruritus were 45% vs. 98.8%, 12.5% vs. 95.9%, and 8.8% vs. 95%, respectively (HR:37.829, 95%CI: 24.385–58.686, p<0.001). In the ear keloid subgroup, the 1-year, 3-year and 5-year local control rates for patients with pruritus were significantly lower than those without pain or pruritus (60.0% vs. 97.9%, 26.7% vs. 94.7%, 26.7% vs. 94.3%, HR:30.209, 95% CI:14.793–61.69, p<0.001). The same results were found in other location(p<0.001). During treatment and follow-up, two patients experienced infections, and one patient developed a cutaneous fibroblastoma.

Conclusion

This study suggests that a combination of surgery followed by short-course, every-other-day radiotherapy can yield satisfactory local control rates for keloids. Pain and or pruritus symptom was an independently prognostic factors for recurrence of keloid. To further validate these results, a prospective randomized controlled trial is recommended.

Introduction

Keloids are pathological scar tissues that develop as a result of skin trauma or spontaneous formation and subsequent overgrowth. They typically occur due to burns, piercings, tattoos, surgery, or other forms of skin trauma. Keloid formation is characterized by an imbalance in collagen synthesis and extracellular matrix production, coupled with reduced degradation of these components. Inflammatory mediators are believed to play a role in influencing collagen synthesis and remodeling of the extracellular matrix during scar healing. Overactivation of keloid fibroblasts, driven by the overexpression of inflammatory mediators, is associated with increased collagen synthesis and extracellular matrix production [1]. Keloids are characterized by their raised, irregularly shaped, and invasive growth beyond the boundaries of the original wound or skin injury. They do not resolve spontaneously and often present with symptoms such as pain or pruritus. People with darker skin such as blacks and Asians individuals are more likely to develop keloids, with an incidence of about 5–16% [2]. The increasing incidence and recurrence of keloid can seriously impact patient’s physical and mental health [3].

Keloid can be treated with corticosteroid injection, compression therapy, surgery, physical therapy, radiation therapy and other methods [4]. Corticosteroid injections are most commonly used treatment, with recurrence rates ranging from 5 to 50%. However, injections are often painful for most patients [5, 6]. Compression therapy is an effective treatment for keloid, but patient compliance is often poor because it always takes at least half a year [7]. Surgery alone has a high recurrence rate ranging from 45 to 100%, and published data indicate that using surgery as a single treatment for keloids is insufficient [8, 9]. Radiotherapy is often conducted after surgical resection because it can effectively prevent keloid recurrence by inhibiting angiogenesis and inflammatory response [10, 11]. A recent meta-analysis, which included 72 studies, reported that surgery followed by radiotherapy could achieved a lower recurrences of 22%, indicating the potential effectiveness of this treatment modality for keloid [12]. Dose-effect studies suggest that a biological effective dose (BED) of 30 Gy is considered the optimal radiation dose. Higher BED doses do not further reduce the recurrence rate but increase side effects [10, 13, 14]. However, there is still a lack of consensus on optimal postoperative radiotherapy dose and fractions for keloid, especially based on different keloid regions and patient main complaints.

The aim of this study was to investigate the efficacy of surgery followed by a short-course radiotherapy administered every other day, a common protocol in our institute for treating keloids. Additionally, the study aimed to analyze prognostic factors associated with keloid recurrence.

Materials and methods

Patients

We conducted a retrospective review of clinical data from keloid patients who received postoperative radiotherapy at Xijing Hospital from January 2010 to December 2017. We collected the following patient characteristics for analysis: gender, age, cause, longest axis, keloid location, number of keloids, treatment history before radiotherapy, and accompanying symptoms such as pain, pruritus, and duration of symptoms. All patients provided consent for the treatment protocol, and the study was conducted in accordance with the principles of the Declaration of Helsinki.

Radiotherapy

Electron beam with energy of 4 MeV was used for radiotherapy. The target area of irradiation was 0.5–1 cm around the incision suture line, and the bolus with 0.5 cm was covered to increase the epidermal dose. At the same time, lead blocks were used to protect normal tissue. The total dose was 16 Gy with 4 fractions, administered once every other day. All patients received radiotherapy within 24 h after surgery.

Acute and late toxicities

Radiotherapy-related toxicity was evaluated according to the Acute and Late Radiation Morbidity Scoring Criteria of Radiation Therapy Oncology Group (RTOG). The toxicities were evaluated after radiotherapy every 3 months for the first year and every 3–6 months for the next two years.

Statistical analysis

The follow-up period was measured from the beginning of radiotherapy to the time of recurrence or the last follow-up before analysis. The primary endpoint was local control which was defined as any clinical evidence of a keloid developing at the incision site, regardless of the size, as determined with a focused physical examination by the treating radiation oncologist, dermatologist, plastic surgeon, or otolaryngologist in follow-up. Receiver operating characteristic (ROC) curves were used to convert the continuous variables into two subgroups at their cutoff values identified by recurrence. The Chi-square test was used to compare the categorical variables (expressed in frequency or percentage). The Kaplan–Meier curve was used to calculate estimated rates of the percent of local control. The differences in the time-to-event outcomes between groups were compared by log-rank tests. Univariate and multivariate Cox analyses were used to detect prognostic factors for local control. A two-tailed P value < 0.05 was considered as statistically significant difference. The SPSS (version 24.0, IBM, USA) was used for statistical analyses.

Results

Patient characteristics

Among the patients, there were 126 (25.3%) male and 372 female (74.7%). The median age was 25 years (range: 4–77 years). Of all patients, 32 (6.4%) had more than 2 keloids and 466 (93.4%) had a single keloid. The causes of keloids were 298(59.8%) piercing, 44(8.8%) scar, 63(12.7%) acne, 56(11.2%) trauma, and 37(7.4%) other respectively. The longest axis of keloids was less than 5 cm in 64.7% of cases, between 5 cm and less than 10 cm in 14.9% of cases, and greater than 10 cm in 20.5% of cases, respectively. Eighty-one patients (16.3%) experienced pain or pruritus as a symptom. Among these, 9 patients had pruritus for less than 6 months, 4 patients for 6 to 12 months, and 68 patients for more than 12 months. All patients received comprehensive surgical-based treatment before undergoing radiotherapy. This included 337 patients who had surgery alone, 18 who received surgery combined with compress therapy, 26 who had surgery combined with corticosteroid therapy, 82 who underwent surgery in addition to silicone treatment, and 35 who received more than three kinds of comprehensive treatments (Table 1). For patients who received surgery combined with other treatments, all previous treatments were administered before the new surgery plus radiotherapy, as these treatments were found to be ineffective.

Table 1 Baseline characteristics for patients
Full size table

Local control and prognostic factors

At the last follow-up, 130 (26.5%) keloids had recurred after a median follow-up of 68.1 months (range: 42.6-129.9 months). In the group that underwent surgery only followed by radiotherapy, 65 recurrences were observed. Meanwhile, in the group receiving combined treatments with surgery followed by radiotherapy, 65 recurrences were found. The local control rates at 1 year, 3 years and 5 years for all patients were 89.5%, 82.5% and 81%, respectively (Fig. 1). Keloids in chest region had the highest recurrence rate (50.8%) (Supplemental Fig. 1), followed by suprapubic (47.8%), head neck (38.8%), limbs (33.3%) and the lowest recurrence rate of ear (14%) (Supplemental Fig. 2). Multivariate analysis was conducted to identify independent prognostic factors using the following covariates: age, sex, cause, longest axis, number of keloids, location, pruritus, duration of pruritus, treatment before radiotherapy. Pain and or pruritus was an independent prognostic factors for keloid recurrence detected by multivariate analysis (HR:14.926, 95%CI:6.760-32.958, p<0.0001)(Table 2). The local control rates at 1-year, 3-years and 5-years in patients with or without pain and or pruritus were 45% vs. 98.8%, 12.5% vs. 95.9%, and 8.8% vs. 95%, respectively (HR:37.829, 95%CI:24.385–58.686, p<0.001) (Fig. 2).

Fig. 1
figure 1

Kaplan-Meier analysis of local control rate for all patients

Full size image
Fig. 2
figure 2

Kaplan-Meier analysis of local control rate for patients accompanied by pain and/or pruritus

Full size image

The 1-year, 3-year and 5-year local control rates of patients with pain and or pruritus were lower than those without symptom in ear keloid subgroup (60.0% vs. 97.9%, 26.7% vs. 94.7%, 26.7% vs. 94.3%, HR:30.209, 95%CI:14.793–61.69, p<0.001)(Fig. 3). The same results were found in other location (Supplemental Table 1).

Fig. 3
figure 3

Kaplan-Meier analysis of local control rate of patients with ear keloid accompanied by pain and/or pruritus

Full size image
Table 2 Univariable and multivariate Cox analysis of local control
Full size table

Toxicities

During the radiation course and follow-up period, two patient experienced wound infection, and there were no cases of grade ≥ 2 radiation dermatitis, bleeding, or poor wound healing. During follow-up, one patient developed fibroblastoma in the radiation field at the suprapubic site. (Table 3).

Table 3 Acute and late toxicity
Full size table

Discussion

It is widely accepted that surgical resection followed by radiotherapy is a rapid and effective method for treating keloids [11, 15, 16]. Many studies confirmed that surgery followed by radiotherapy could effectively reduce the recurrence rate of keloid and improve the quality of life of patients [9, 14, 17, 18]. However, in the past few years, there was no consensus on the dose and fraction of radiotherapy, and the treatment model varies from different institutes.

Studies have shown that postoperative radiation can significantly reduce the risk of keloid recurrence [7, 17, 19, 20]. A study included 124 patients with 250 keloid lesions reported that surgery followed by radiotherapy with 20 Gy in 5 fractions yielded an excellent local control rate of 94.4% [14]. Another study further verified the effectiveness of the radiotherapy regimen in keloid treatment, with a satisfactory local control rate of 84.8% [20]. Rei et al. reported adjusted radiotherapy regimens according to keloid locations achieved local control rate of 90%, such as 18 Gy radiation dose in 3 fractions to anterior chest wall and scapular region, 8 Gy radiation dose in 1 fraction to earlobes and 15 Gy in 2 fractions to other body site [10]. In this study, we reported comparable cumulative local control rates after a median follow-up of 68.1months. The local control rates of 1 year, 3 years and 5 years were 88.5%, 82.5% and 71%, respectively. This result was consistent with published data [14, 21]. Moreover, the correlation between local control and keloid location was established by our study. The keloid located on chest had the highest recurrence rate, while keloid located on ear had lowest recurrence rate. Similar results were also reported by other study [22]. The prescription BED was similar to other studies, and also achieved a satisfactory effect. But for high recurrence areas, such as the chest and abdomen, perineum, limbs and other high-tension areas, the prescribed BED in this study is slightly lower than some other studies, so this should be one of the reasons for the slightly higher recurrence rates in those areas in this study. It is still unclear why the lesion site can impact the recurrence of keloids. This may be explained by two reasons: ①the skin located on chest always has higher tension which is known to be a risk factor for keloid formation [23, 24]; ②the percentage of collagen, which is higher at chest and back, may contribute to keloid formation [25]. Therefore, the dose and fraction of radiotherapy should be delivered according to the keloid site.

In this study, we firstly reported that symptom of pain and or pruritus were independently prognostic factors for keloid recurrence regardless of keloid site. Although the exact reasons are not clear, these symptoms may be attributed to angiogenesis and fibroblast proliferation [26]. Compared keloid without pruritus symptom, keloid with pruritus always have increased number and density of dermal mast cells and their stored granules, which were considered as important factor to stimulate fibroblast activity and collagen formation [27]. Moreover, patients with high concentrations of inflammatory cells infiltration in keloid tissue were more susceptible to have pruritus symptom [28]. The factors mentioned above are closely associated with keloid formation. That may make it easier to understand why patients with pruritus have higher recurrence rate.

According to literature reports, the occurrence rates of radiotherapy related complications vary greatly and are related to multiple factors [29]. In our study, there were no patients with radiation induced dermatitis, bleeding, and poor wound healing. During treatment and follow-up, infection occurred in 2 patients and cutaneous fibroblastoma in 1 patient. The incidence of infection was significantly lower than that reported in the literature with 4.3-8% [9]. At present, there are few reports of cancer caused by radiation therapy for keloids. Biemans et al. reported a case of fibrosarcoma, which may be related to the carcinogenic effects of radiotherapy. In addition, Raghuvanci et al. reported 5 cases of keloid secondary malignancy after radiotherapy, but there is still no definite conclusion [13]. There were no patients developed cutaneous malignant in the radiotherapy field in this study. However, the cutaneous fibroblastoma was potentially associated with radiotherapy.

There are several limitations for this study. Firstly, the retrospective design of this study may result in bias that impact the accuracy of conclusion. Secondly, the single-center design makes it difficult to widely generalize the radiotherapy protocol. Therefore, a prospective, multicenter, randomized controlled trials are needed to confirm the result of this study.

Conclusion

This study suggested that surgery followed by short-course every other day radiotherapy could achieve a satisfactory local control rate for keloid. Pain and or pruritus symptom was an independently prognostic factors for recurrence of keloid. A prospective randomized controlled study is need to further confirm this result.

Data availability

No datasets were generated or analysed during the current study.

Abbreviations

BED:

Biological effective dose

CI:

Confidence intervals

HR:

Hazard ratios

ROC:

Receiver operating characteristic

RTOG:

Radiation therapy oncology group

References

  1. Udayan B, Travis WB, Keloids. A review of etiology, prevention, and treatment. J Clin Aesthet Dermatol. 2020;13(2):33–43.

    Google Scholar 

  2. Jones CD, Guiot L, Samy M, Gorman M, Tehrani H. The use of chemotherapeutics for the treatment of keloid scars. Dermatol Rep. 2015;7(2):5880.

    Article  Google Scholar 

  3. Bijlard E, Kouwenberg CA, Timman R, Hovius SE, Busschbach JJ, Mureau MA. Burden of keloid disease: a cross-sectional health-related quality of life assessment. Acta Derm Venereol. 2017;97(2):225–9.

    Article  PubMed  Google Scholar 

  4. Ogawa R, Akita S, Akaishi S, Aramaki-Hattori N, Dohi T, Hayashi T, Kishi K, Kono T, Matsumura H, Muneuchi G, et al. Diagnosis and treatment of keloids and hypertrophic scars-Japan Scar Workshop Consensus Document 2018. Burns Trauma. 2019;7:39.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Poetschke J, Gauglitz GG. Current options for the treatment of pathological scarring. J Dtsch Dermatol Ges. 2016;14(5):467–77.

    PubMed  Google Scholar 

  6. Berman B, Maderal A, Raphael B. Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg. 2017;43(Suppl 1):S3–18.

    Article  CAS  PubMed  Google Scholar 

  7. Kim SW. Management of keloid scars: noninvasive and invasive treatments. Arch Plast Surg. 2021;48(2):149–57.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, Stella M, Teot L, Wood FM, Ziegler UE, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110(2):560–71.

    Article  PubMed  Google Scholar 

  9. Dong W, Qiu B, Fan F. Adjuvant radiotherapy for keloids. Aesthetic Plast Surg. 2022;46(1):489–99.

    Article  PubMed  Google Scholar 

  10. Ogawa R, Tosa M, Dohi T, Akaishi S, Kuribayashi S. Surgical excision and postoperative radiotherapy for keloids. Scars Burn Heal. 2019;5:2059513119891113.

    PubMed  PubMed Central  Google Scholar 

  11. Ogawa R, Miyashita T, Hyakusoku H, Akaishi S, Kuribayashi S, Tateno A. Postoperative radiation protocol for keloids and hypertrophic scars. Ann Plast Surg. 2007;59(6):688–91.

    Article  CAS  PubMed  Google Scholar 

  12. Mankowski P, Kanevsky J, Tomlinson J, Dyachenko A, Luc M. Optimizing radiotherapy for keloids. Ann Plast Surg. 2017;78(4):403–11.

    Article  CAS  PubMed  Google Scholar 

  13. Ogawa R, Yoshitatsu S, Yoshida K, Miyashita T. Is radiation therapy for keloids acceptable? The risk of Radiation-Induced Carcinogenesis. Plast Reconstr Surg. 2009;124(4):1196–201.

    Article  CAS  PubMed  Google Scholar 

  14. Renz P, Hasan S, Gresswell S, Hajjar RT, Trombetta M, Fontanesi J. Dose effect in adjuvant radiation therapy for the treatment of resected keloids. Int J Radiat Oncol Biol Phys. 2018;102(1):149–54.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Flickinger JC. A radiobiological analysis of multicenter data for postoperative keloid radiotherapy. Int J Radiation Oncology*Biology*Physics. 2011;79(4):1164–70.

    Article  Google Scholar 

  16. Kal HB, Veen RE. Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Strahlenther Onkol. 2005;181(11):717–23.

    Article  PubMed  Google Scholar 

  17. Siotos C, Uzosike AC, Hong H, Seal SM, Rosson GD, Cooney CM, Cooney DS. Keloid excision and adjuvant treatments. Ann Plast Surg. 2019;83(2):154–62.

    Article  CAS  PubMed  Google Scholar 

  18. Ellis MM, Jones LR, Siddiqui F, Sunkara PR, Ozog DM. The efficacy of surgical excision plus adjuvant multimodal therapies in the treatment of keloids: a systematic review and meta-analysis. Dermatol Surg. 2020;46(8):1054–9.

    Article  CAS  PubMed  Google Scholar 

  19. Liu W, Shi M, Su H, et al. Effect of age as a continuous variable on survival outcomes and treatment selection in patients with extranodal nasal-type NK/T-cell lymphoma from the China Lymphoma Collaborative Group (CLCG). Aging. 2019;11:8463–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Wen P, Wang T, Zhou Y, Yu Y, Wu C. A retrospective study of hypofractionated radiotherapy for keloids in 100 cases. Sci Rep. 2021;11(1):3598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Sruthi K, Chelakkot PG, Madhavan R, Nair RR, Dinesh M. Single-fraction radiation. J Cancer Res Ther. 2018;14(6):1251–5.

    Article  CAS  PubMed  Google Scholar 

  22. Chen F, Kuo Y-R, Huang C-J, Tang J-Y, Chiang C-H, Huang M-Y. Lesion site is the key prognostic factor for keloid patients receiving surgery with adjuvant radiotherapy. Ann Plast Surg. 2022;89(6):626–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18(3).

  24. Akaishi S, Akimoto M, Ogawa R, Hyakusoku H. The relationship between keloid growth pattern and stretching tension. Ann Plast Surg. 2008;60(4):445–51.

    Article  CAS  PubMed  Google Scholar 

  25. Butzelaar L, Niessen FB, Talhout W, Schooneman DPM, Ulrich MM, Beelen RHJ, van der Mink AB. Different properties of skin of different body sites: the root of keloid formation? Wound Repair Regeneration. 2017;25(5):758–66.

    Article  PubMed  Google Scholar 

  26. Lee S-S, Yosipovitch G, Chan Y-H, Goh C-L. Pruritus, pain, and small nerve fiber function in keloids: a controlled study. J Am Acad Dermatol. 2004;51(6):1002–6.

    Article  PubMed  Google Scholar 

  27. Hawash AA, Ingrasci G, Nouri K, Yosipovitch G. Pruritus in keloid scars: mechanisms and treatments. Acta Dermato-Venereologica. 2021;101(10).

  28. Jumper N, Paus R, Bayat A. Functional histopathology of keloid disease. Histol Histopathol. 2015;30:1033–57.

    CAS  PubMed  Google Scholar 

  29. Sakamoto T, Oya N, Shibuya K, Nagata Y, Hiraoka M. Dose-response relationship and dose optimization in radiotherapy of postoperative keloids. Radiother Oncol. 2009;91(2):271–6.

    Article  PubMed  Google Scholar 

Download references

Funding

This work was supported by grants from the general key research and development projects in Shaanxi Province, China: 2022SF-027.

Author information

Author notes

  1. Wei Zhou is the fisrt author.

Authors and Affiliations

  1. Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi’an, China

    Wei Zhou, Yutian Yin, Lihua Zhang, Yan Zhou, Lin Xu, Jian Zang & Lina Zhao

  2. State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, China

    Lina Zhao

  3. Dermatology Department, Xijing Hospital, Fourth Military Medical University, Xi’an, China

    Bing Li

Authors
  1. Wei Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yutian Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lihua Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yan Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lin Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jian Zang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lina Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Wei Zhou: Conceptualization, Data curation, Investigation, Writing – original draft. Bing Li: Resources, Data curation, Investigation, Data curation. Yutian Yin: Formal analysis, Software, Methodology. Lihua Zhang: Resources, Visualization, Data curation. Yan Zhou: Resources, Data curation. Lin Xu: Visualization, Validation. Jian Zang: Supervision, Writing - review & editing, Funding acquisition. Lina Zhao: Project administration, Supervision, Writing - review & editing.

Corresponding authors

Correspondence to Jian Zang or Lina Zhao.

Ethics declarations

Ethical approval and consent to participate

Patient consent was waived by the Ethics Committee of Xijing Hospital, the Fourth Military Medical University; due to this study being retrospective, it was impossible to obtain informed consent.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary Material 1

Supplementary Material 2

Supplementary Material 3

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, W., Li, B., Yin, Y. et al. Treatment outcomes of surgery followed by short-course every other day radiotherapy in keloid. Radiat Oncol 19, 91 (2024). https://doi.org/10.1186/s13014-024-02488-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s13014-024-02488-5

Keywords

Radiation Oncology

ISSN: 1748-717X

Contact us