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  1. Content type: Research

    Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over t...

    Authors: Carsten Nieder, Matthias Guckenberger, Laurie E. Gaspar, Chad G. Rusthoven, Dirk De Ruysscher, Arjun Sahgal, Timothy Nguyen, Anca L. Grosu and Minesh P. Mehta

    Citation: Radiation Oncology 2019 14:33

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  2. Content type: Research

    Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-r...

    Authors: Seth Helfenstein, Oliver Riesterer, Urs R. Meier, Alexandros Papachristofilou, Benjamin Kasenda, Miklos Pless and Sacha I. Rothschild

    Citation: Radiation Oncology 2019 14:32

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  3. Content type: Research

    In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competi...

    Authors: Juan Huang, Fang-fang Kong, Ronald Wihal Oei, Rui-ping Zhai, Chao-su Hu and Hong-mei Ying

    Citation: Radiation Oncology 2019 14:31

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  4. Content type: Research

    Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosim...

    Authors: Sophie Jacob, Jérémy Camilleri, Sylvie Derreumaux, Valentin Walker, Olivier Lairez, Mathieu Lapeyre, Eric Bruguière, Atul Pathak, Marie-Odile Bernier, Dominique Laurier, Jean Ferrieres, Olivier Gallocher, Igor Latorzeff, Baptiste Pinel, Denis Franck, Christian Chevelle…

    Citation: Radiation Oncology 2019 14:29

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  5. Content type: Research

    Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay e...

    Authors: Kai Dolde, Ye Zhang, Naved Chaudhri, Christian Dávid, Marc Kachelrieß, Antony John Lomax, Patrick Naumann, Nami Saito, Damien Charles Weber and Asja Pfaffenberger

    Citation: Radiation Oncology 2019 14:30

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  6. Content type: Review

    This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

    Authors: Motomasa Furuse, Naosuke Nonoguchi, Kei Yamada, Tohru Shiga, Jean-Damien Combes, Naokado Ikeda, Shinji Kawabata, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2019 14:28

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  7. Content type: Research

    Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might in...

    Authors: Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero and Irenäus A. Adamietz

    Citation: Radiation Oncology 2019 14:25

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  8. Content type: Research

    The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in ad...

    Authors: S. Gwynne, E. Higgins, A. Poon King, G. Radhakrishna, L. Wills, S. Mukherjee, Maria Hawkins, G. Jones, J. Staffurth and T. Crosby

    Citation: Radiation Oncology 2019 14:26

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  9. Content type: Research

    Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light...

    Authors: G. Vogin, A. Wambersie, M. Koto, T. Ohno, M. Uhl, P. Fossati and J. Balosso

    Citation: Radiation Oncology 2019 14:24

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  10. Content type: Research

    To compare WBC counts during treatment of localized prostate cancer with either conventionally fractionated (CF) or moderately hypofractionated (HYPO) radiotherapy.

    Authors: Giuseppe Sanguineti, Diana Giannarelli, Maria Grazia Petrongari, Stefano Arcangeli, Angelo Sangiovanni, Biancamaria Saracino, Alessia Farneti, Adriana Faiella, Mario Conte and Giorgio Arcangeli

    Citation: Radiation Oncology 2019 14:23

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  11. Content type: Methodology

    Despite the advances in oncology, patients with bulky tumors have worse prognosis and often receive only palliative treatments. Bulky disease represents an important challenging obstacle for all currently avai...

    Authors: Slavisa Tubin, Helmut H. Popper and Luka Brcic

    Citation: Radiation Oncology 2019 14:21

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  12. Content type: Research

    Three-dimensional ultrasound (3DUS) is an attractive option in image-guided radiotherapy (IGRT) for prostate cancer (PCa) patients. However, the potential factors influencing the accuracy of 3DUS in comparison...

    Authors: Sha Zhou, Liling Luo, Jibin Li, Maosheng Lin, Li Chen, Jianhui Shao, Shipei Lu, Yaru Ma, Yingting Zhang, Wenfen Chen, Mengzhong Liu, Shiliang Liu and Liru He

    Citation: Radiation Oncology 2019 14:22

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  13. Content type: Research

    This study aimed to evaluate the role of postoperative radiotherapy (RT) in dermatofibrosarcoma protuberans (DFSP) and identify the prognostic factors influencing the disease-free survival (DFS).

    Authors: Kaixin Du, Jinluan Li, Lirui Tang, Xiaoyi Lin, Xiangquan Kong, Xuehong Liao, Qingqin Peng, Yaping Dong, Junyan He, Yunxia Huang, Xueqing Zhang, Feifei Lin, Qingyang Zhuang and Junxin Wu

    Citation: Radiation Oncology 2019 14:20

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  14. Content type: Research

    Helical irradiation of the total skin (HITS) was modified as simultaneous integrated boost (SIB)-helical arc radiotherapy of total skin (HEARTS) technique and applied to an acute myeloid leukemia (AML) patient...

    Authors: Chen-Hsi Hsieh, Hui-Ju Tien, Yuan-Bin Yu, Yuan-Hung Wu, Pei-Wei Shueng, Yueh-Feng Lu, Shan-Ying Wang and Li-Ying Wang

    Citation: Radiation Oncology 2019 14:17

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  15. Content type: Research

    Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to im...

    Authors: Corey C. Foster, David J. Sher, Chad G. Rusthoven, Vivek Verma, Michael T. Spiotto, Ralph R. Weichselbaum and Matthew Koshy

    Citation: Radiation Oncology 2019 14:18

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  16. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening comp...

    Authors: Hakyoung Kim, Hongryull Pyo, Jae Myoung Noh, Woojin Lee, Byoungsuk Park, Hye Yun Park and Hongseok Yoo

    Citation: Radiation Oncology 2019 14:19

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  17. Content type: Research

    To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

    Authors: Jian Chen, Jiade J. Lu, Ningyi Ma, Jingfang Zhao, Chang Chen, Min Fan, Guoliang Jiang and Jingfang Mao

    Citation: Radiation Oncology 2019 14:16

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  18. Content type: Research

    The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.

    Authors: Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Eduardo Tadashi Pinto Emi, Camila de Carvalho Almança Lopes, Flaviana Soares Rocha, Jonas Dantas Batista, Gustavo Davi Rabelo and Paula Dechichi

    Citation: Radiation Oncology 2019 14:15

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  19. Content type: Research

    We created a scoring system incorporating dosimetric and clinical factors to assess the risk of severe, acute skin reactions in patients undergoing intensity-modulated radiation therapy (IMRT) to treat head an...

    Authors: Mitsue Kawamura, Michio Yoshimura, Hiromi Asada, Mitsuhiro Nakamura, Yukinori Matsuo and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:14

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  20. Content type: Research

    The purpose of this study was to compare automatically generated VMAT plans to find the superior beam configurations for Pinnacle3 Auto-Planning and share “best practices”.

    Authors: Anne Richter, Florian Exner, Klaus Bratengeier, Bülent Polat, Michael Flentje and Stefan Weick

    Citation: Radiation Oncology 2019 14:12

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  21. Content type: Research

    The selection of radiation therapy dose fractionation schedules for bone metastases is often based on the estimation of life expectancy. Therefore, accurate prognosis prediction is an important issue. It is re...

    Authors: Hikaru Kubota, Toshinori Soejima, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Kayoko Tsujino, Ikuo Fujita, Takuya Fujimoto, Masayuki Morishita, Junichi Ikegaki, Koji Matsumoto and Ryohei Sasaki

    Citation: Radiation Oncology 2019 14:13

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  22. Content type: Research

    Induction chemotherapy (IC) now is gaining recognition for the treatment of nasopharyngeal carcinoma (NPC). The current study was conducted to examine the association between prognosis and the interval between...

    Authors: Liang Peng, Jin-Qi Liu, Cheng Xu, Xiao-Dan Huang, Ling-Long Tang, Yu-Pei Chen, Ying Sun and Jun Ma

    Citation: Radiation Oncology 2019 14:9

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  23. Content type: Research

    The implementation of magnetic resonance imaging (MRI) guided radiotherapy (RT) continues to increase. Very limited in-vitro data on the interaction of ionizing radiation and magnetic fields (MF) have been pub...

    Authors: B. Yudhistiara, F. Zwicker, K. J. Weber, P. E. Huber, A. Ruehle, S. Brons, P. Haering, J. Debus and S. H. Hauswald

    Citation: Radiation Oncology 2019 14:11

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  24. Content type: Research

    The aim of this study is to evaluate the prognostic value of grading MRI–detected skull-base invasion in nasopharyngeal carcinoma (NPC) with skull-base invasion after intensity-modulated radiotherapy (IMRT).

    Authors: Yanru Feng, Caineng Cao, Qiaoying Hu and Xiaozhong Chen

    Citation: Radiation Oncology 2019 14:10

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  25. Content type: Research

    The optimal care for pT3N0 rectal cancer remains controversial. And whether tumor location can be used to guide the administration of adjuvant radiotherapy for pT3N0 rectal cancer is not fully confirmed. The c...

    Authors: Hai-hua Peng, Xin-hui Zhou, Tong-chong Zhou, Xing-sheng Qiu and Kai-yun You

    Citation: Radiation Oncology 2019 14:8

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  26. Content type: Research

    Lung dose-volume histogram (DVH) in radiotherapy could be calculated from multiple normal lung definitions. The lung dosimetric parameters generated from various approaches are significantly different. However...

    Authors: Yinnan Meng, Haihua Yang, Wei Wang, Xingni Tang, Caiping Jiang, Yichao Shen and Wei Luo

    Citation: Radiation Oncology 2019 14:7

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  27. Content type: Research

    Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this stud...

    Authors: Hui Lu, Qi Zhao, Jiang Guo, Binghui Zeng, Xinlin Yu, Dongsheng Yu and Wei Zhao

    Citation: Radiation Oncology 2019 14:5

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  28. Content type: Research

    We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end...

    Authors: Boram Ha, Kwan Ho Cho, Kang Hyun Lee, Jae Young Joung, Yeon-Joo Kim, Sung Uk Lee, Hyunjung Kim, Yang-Gun Suh, Sung Ho Moon, Young Kyung Lim, Jong Hwi Jeong, Haksoo Kim, Weon Seo Park and Sun Ho Kim

    Citation: Radiation Oncology 2019 14:4

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  29. Content type: Study protocol

    This study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate cancer (HRPC) presenting with a dominant debilitating symptom.

    Authors: Jesper Carl, Dirk Rades, Claudia Doemer, Cornelia Setter, Jürgen Dunst and Niels Henrik Holländer

    Citation: Radiation Oncology 2019 14:3

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  30. Content type: Research

    Advanced radiotherapy (RT) techniques allow normal tissue to be spared in patients with extremity soft tissue sarcoma (STS). This work aims to evaluate toxicity and outcome after neoadjuvant image-guided radio...

    Authors: Jan C. Peeken, Christoph Knie, Kerstin A. Kessel, Daniel Habermehl, Severin Kampfer, Hendrik Dapper, Michal Devecka, Rüdiger von Eisenhart-Rothe, Katja Specht, Wilko Weichert, Klaus Wörtler, Carolin Knebel, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:2

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  31. Content type: Research

    Due to the heterogeneity of patient’s individual respiratory motion pattern in lung stereotactic body radiotherapy (SBRT), treatment planning dose assessment using a traditional four-dimensional computed tomog...

    Authors: Gang Liu, Fala Hu, Xuanfeng Ding, Xiaoqiang Li, Qihong Shao, Yuenan Wang, Jing Yang and Hong Quan

    Citation: Radiation Oncology 2019 14:1

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  32. Content type: Research

    Small cell lung cancer (SCLC) can recur in the brain after whole-brain irradiation (WBI). We documented outcomes after treatment of such recurrences and sought predictors of local control and overall survival ...

    Authors: Ryoko Suzuki, Xiong Wei, Pamela K. Allen, James W. Welsh, James D. Cox, Ritsuko Komaki and Steven H. Lin

    Citation: Radiation Oncology 2018 13:258

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  33. Content type: Research

    Local progression-free survival (LPFS = stable or improved motor function/resolution of paraplegia during RT without in-field recurrence following RT) is important when treating metastatic spinal cord compress...

    Authors: Dirk Rades, Antonio J. Conde-Moreno, Jon Cacicedo, Theo Veninga, Barbara Segedin, Karmen Stanic and Steven E. Schild

    Citation: Radiation Oncology 2018 13:257

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  34. Content type: Research

    This study aimed to evaluate the inter-fraction set-up error and intra-fraction motion during reverse semi-decubitus (RSD) breast radiotherapy, and to determine a planning target volume (PTV) margin.

    Authors: Jie Lee, Shih-Hua Liu, Jhen-Bin Lin, Meng-Hao Wu, Chieh-Ju Wu, Hung-Chi Tai, Shih-Ming Hsu, Yin-Ju Chen, Jo-Chiao Tai and Yu-Jen Chen

    Citation: Radiation Oncology 2018 13:254

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  35. Content type: Research

    PRIMO is a dose verification system based on the general-purpose Monte Carlo radiation transport code penelope, which implements an accurate physics model of the interaction cross sections and the radiation trans...

    Authors: Miguel Rodriguez, Josep Sempau, Christian Bäumer, Beate Timmermann and Lorenzo Brualla

    Citation: Radiation Oncology 2018 13:256

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  36. Content type: Research

    Elective use of radiation therapy to treat regionally involved lymph nodes (LNs) after radical surgery for esophageal squamous cell carcinoma (ESCC) is controversial. We studied metastasis patterns through a p...

    Authors: Xiaofei Zhang, Xi Yang, Jianjiao Ni, Yida Li, Liqing Zou, Li Chu, Xiao Chu, Fan Xia and Zhengfei Zhu

    Citation: Radiation Oncology 2018 13:255

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  37. Content type: Research

    Although stereotactic radiotherapy (SRT) for vestibular schwannoma has demonstrated excellent local control rates, hearing deterioration is often reported after treatment. We therefore wished to assess the cha...

    Authors: A. van Linge, R. van Os, N. Hoekstra, B. Heijmen, L. Stienstra, A. Dallenga, J. Wolbers and A. Mendez Romero

    Citation: Radiation Oncology 2018 13:253

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  38. Content type: Study protocol

    Stereotactic radiosurgery (SRS) has emerged as a common adjuvant modality used with surgery for resectable brain metastases (BMs). However, the optimal sequence of the multi-modality therapy has not been estab...

    Authors: Wei X. Huff, Namita Agrawal, Scott Shapiro, James Miller, Charles Kulwin, Mitesh Shah, Jesse J. Savage, Troy Payner, Alexander Vortmeyer, Gordon Watson and Mahua Dey

    Citation: Radiation Oncology 2018 13:252

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  39. Content type: Research

    The dismal overall survival (OS) prognosis of glioblastoma, even after trimodal therapy, can be attributed mainly to the frequent incidence of intracranial relapse (ICR), which tends to present as an in-field ...

    Authors: Sebastian Zschaeck, Peter Wust, Reinhold Graf, Martin Misch, Julia Onken, Pirus Ghadjar, Harun Badakhshi, Julian Florange, Volker Budach and David Kaul

    Citation: Radiation Oncology 2018 13:251

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  40. Content type: Research

    The role of the dose escalation strategy in brain radiotherapy for small cell lung cancer (SCLC) patients with brain metastases (BMs) has not been identified. This study aims to determine whether an additional...

    Authors: Han Sun, Liming Xu, Youyou Wang, Junhua Zhao, Kunpeng Xu, Jing Qi, Zhiyong Yuan, Lujun Zhao and Ping Wang

    Citation: Radiation Oncology 2018 13:250

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  41. Content type: Research

    To report our experience in planning and delivering total marrow irradiation (TMI) and total marrow and lymphatic irradiation (TMLI) in patients with hematologic malignancies.

    Authors: Zhirong Bao, Hongli Zhao, Dajiang Wang, Jian Gong, Yahua Zhong, Yu Xiong, Di Deng, Conghua Xie, An Liu, Xiaoyong Wang and Hui Liu

    Citation: Radiation Oncology 2018 13:248

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  42. Content type: Research

    Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether treatment outcomes of cervical adenocarcinoma are equivalent to SC...

    Authors: Ke Hu, Weiping Wang, Xiaoliang Liu, Qingyu Meng and Fuquan Zhang

    Citation: Radiation Oncology 2018 13:249

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  43. Content type: Research

    The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with e...

    Authors: Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Daisuke Shimizu, Takuya Kimoto, Atsushi Shiozaki, Osamu Dohi, Hitoshi Fujiwara, Takeshi Ishikawa, Hirotaka Konishi, Yuji Naito, Eigo Otsuji and Kei Yamada

    Citation: Radiation Oncology 2018 13:246

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  44. Content type: Research

    The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and af...

    Authors: Yu Yang Soon, Huili Zheng, Shaun Zhirui Ho, Wee Yao Koh, Cheng Nang Leong, Jeremy Chee Seong Tey, Balamurugan Vellayappan, Swee Peng Yap, Ivan Weng Keong Tham and Kam Weng Fong

    Citation: Radiation Oncology 2018 13:247

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  45. Content type: Research

    Oesophageal cancer with airway invasion presents a challenge for therapy and often has serious complications. We analysed the clinical outcomes of radiation therapy (RT) in patients with clinical T4b oesophage...

    Authors: Hakyoung Kim, Dongryul Oh, Yong Chan Ahn, Keunchil Park, Myung-Ju Ahn, Se-Hoon Lee, Jong-Mu Sun, Young Mog Shim, Jae Ill Zo, Yong Soo Choi, Hong Kwan Kim and Jong Ho Cho

    Citation: Radiation Oncology 2018 13:245

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  46. Content type: Research

    Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, ...

    Authors: Verónica García-Vázquez, Begoña Sesé-Lucio, Felipe A. Calvo, Juan J. Vaquero, Manuel Desco and Javier Pascau

    Citation: Radiation Oncology 2018 13:243

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  47. Content type: Research

    Automatic multi-criteria optimization is necessary for intensity modulated radiation therapy (IMRT) because of low planning efficiency and large plan quality uncertainty in current clinical practice. Most stud...

    Authors: Yanhua Mai, Fantu Kong, Yiwei Yang, Linghong Zhou, Yongbao Li and Ting Song

    Citation: Radiation Oncology 2018 13:241

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