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  1. This study evaluates various craniospinal irradiation (CSI) techniques used in Turkish centers to understand their advantages, disadvantages and overall effectiveness, with a focus on enhancing dose distribution.

    Authors: Öznur Şenkesen, Evrim Tezcanlı, Fadime Alkaya, Burçin İspir, Serap Çatlı, Abdullah Yeşil, Ebrar Bezirganoglu, Sezgi Turan, Canan Köksal, Gülay Güray, Emel Hacıislamoğlu, İsmail Faruk Durmuş, Şeyma Çavdar, Telat Aksu, Nurten Çolak, Esra Küçükmorkoç…
    Citation: Radiation Oncology 2024 19:49
  2. Tumor regression and organ movements indicate that a large margin is used to ensure target volume coverage during radiotherapy. This study aimed to quantify inter-fractional movements of the uterus and cervix ...

    Authors: Zheng Zeng, Jiawei Zhu, Zhiqun Wang, Guangyu Wang, Junfang Yan and Fuquan Zhang
    Citation: Radiation Oncology 2024 19:48
  3. Small cell lung cancer (SCLC) is highly invasive with poor prognosis, and its treatment has historically been hindered due to the absence of targetable driver genomic alterations. However, the high genomic ins...

    Authors: Jiuang Mao, Jianjiao Ni, Li Chu, Xiao Chu, Dayu Xu, Xi Yang and Zhengfei Zhu
    Citation: Radiation Oncology 2024 19:47
  4. To evaluate effects of bone marrow sparing (BMS) radiotherapy on decreasing the incidence of acute hematologic toxicity (HT) for locoregionally advanced cervical cancer (LACC) patients treated by pelvic irradi...

    Authors: Wen Li, Lan Ma, Fang Li, Kemin Li, Yang Zhang, Hongtao Ren, Xing Bao, Yuyan Guo, Ya Guo, Mincong Wang, Dan Li, Yuanqiong Duan, Xiulong Ma, Zhongwei Wang, Yali Wang and Rutie Yin
    Citation: Radiation Oncology 2024 19:46
  5. Current automated planning solutions are calibrated using trial and error or machine learning on historical datasets. Neither method allows for the intuitive exploration of differing trade-off options during c...

    Authors: Philip A Wheeler, Nicholas S West, Richard Powis, Rhydian Maggs, Michael Chu, Rachel A Pearson, Nick Willis, Bartlomiej Kurec, Katie L. Reed, David G. Lewis, John Staffurth, Emiliano Spezi and Anthony E. Millin
    Citation: Radiation Oncology 2024 19:45
  6. Fibroblast activation protein (FAP) is expressed in the tumor microenvironment (TME) of various cancers. In our analysis, we describe the impact of dual-tracer imaging with Gallium-68-radiolabeled inhibitors o...

    Authors: Simone Wegen, Karina Claus, Philipp Linde, Johannes Rosenbrock, Maike Trommer, Thomas Zander, Armin Tuchscherer, Christiane Bruns, Hans Anton Schlößer, Wolfgang Schröder, Marie-Lisa Eich, Thomas Fischer, Klaus Schomäcker, Alexander Drzezga, Carsten Kobe, Katrin Sabine Roth…
    Citation: Radiation Oncology 2024 19:44
  7. Solitary fibrous tumors (SFT) of the central nervous system are rare and treatment options are not well established. The aim of this study was to evaluate the clinical outcomes of radiotherapy (RT) and re-radi...

    Authors: Mike Ton, Maximilian Deng, Eva Meixner, Tanja Eichkorn, Anna Krämer, Katharina Seidensaal, Juliane Hörner-Rieber, Jonathan Lischalk, Klaus Herfarth, Jürgen Debus and Laila König
    Citation: Radiation Oncology 2024 19:42
  8. To assess a large panel of MR compatible detectors on the full range of measurements required for a 0.35 T MR-linac commissioning by using a specific statistical method represented as a continuum of comparison...

    Authors: Michel Chea, Mathilde Croisé, Christelle Huet, Céline Bassinet, Mohamed-Amine Benadjaoud and Catherine Jenny
    Citation: Radiation Oncology 2024 19:40
  9. At present, the implementation of intensity-modulated radiation therapy (IMRT) treatment planning for geometrically complex nasopharyngeal carcinoma (NPC) through manual trial-and-error fashion presents challe...

    Authors: Wenwen Cai, Shouliang Ding, Huali Li, Xuanru Zhou, Wen Dou, Linghong Zhou, Ting Song and Yongbao Li
    Citation: Radiation Oncology 2024 19:39
  10. The addition of radiation therapy (RT) to surgery in retroperitoneal sarcoma (RPS) remains controversial. We examined practice patterns in the use of RT for patients with RPS over time in a large, national coh...

    Authors: Samantha M. Ruff, Victor Heh, David J. Konieczkowski, Amblessed Onuma, Hayley M. Dunlop, Alex C. Kim, Valerie P. Grignol, Carlo M. Contreras, Timothy M. Pawlik, Raphael Pollock and Joal D. Beane
    Citation: Radiation Oncology 2024 19:38
  11. Magnetic resonance imaging (MRI) plays an increasingly important role in radiotherapy, enhancing the accuracy of target and organs at risk delineation, but the absence of electron density information limits it...

    Authors: Changfei Gong, Yuling Huang, Mingming Luo, Shunxiang Cao, Xiaochang Gong, Shenggou Ding, Xingxing Yuan, Wenheng Zheng and Yun Zhang
    Citation: Radiation Oncology 2024 19:37
  12. Treatment related lymphopenia is a known toxicity for glioblastoma (GBM) patients and several single-institution studies have linked lymphopenia with poor survival outcomes. We performed a systematic review an...

    Authors: A. M. Saeed, S. M. Bentzen, H. Ahmad, L. Pham, G. F. Woodworth and M. V. Mishra
    Citation: Radiation Oncology 2024 19:36
  13. Diffusion-weighted magnetic resonance imaging (DWI) provides a measurement of tumor cellularity. We evaluated the potential of apparent diffusion coefficient (ADC) values obtained from post-external beam radia...

    Authors: Elizabeth E. Dong, Junqian Xu, Joo-Won Kim, Jason Bryan, Jewel Appleton, Daniel A. Hamstra, Michelle S. Ludwig and Alexander N. Hanania
    Citation: Radiation Oncology 2024 19:35
  14. FLASH therapy is a treatment technique in which radiation is delivered at ultra-high dose rates ( 40 Gy/s). The first-in-human FAST-01 clinical trial demonstrated the clinical feasibility of proton FLASH in the ...

    Authors: EC Daugherty, Y Zhang, Z Xiao, AE Mascia, M Sertorio, J Woo, C McCann, KJ Russell, RA Sharma, D Khuntia, JD Bradley, CB Simone 2nd, JC Breneman and JP Perentesis
    Citation: Radiation Oncology 2024 19:34
  15. Radiotherapy (RT) is an important treatment modality for patients with brain malignancies. Traditionally, computed tomography (CT) images are used for RT treatment planning whereas magnetic resonance imaging (...

    Authors: Johanna Grigo, Juliane Szkitsak, Daniel Höfler, Rainer Fietkau, Florian Putz and Christoph Bert
    Citation: Radiation Oncology 2024 19:33
  16. Centrally located lung tumours present a challenge because of their tendency to exhibit symptoms such as airway obstruction, atelectasis, and bleeding. Surgical resection of these tumours often requires sacrif...

    Authors: Noriko Kishi, Masahiro Yoneyama, Hiroyuki Inoo, Minoru Inoue, Hiraku Iramina, Akiyoshi Nakakura, Tomohiro Ono, Hideaki Hirashima, Takanori Adachi, Norimasa Matsushita, Makoto Sasaki, Takahiro Fujimoto, Mitsuhiro Nakamura, Yukinori Matsuo and Takashi Mizowaki
    Citation: Radiation Oncology 2024 19:32
  17. Longitudinal assessments of apparent diffusion coefficients (ADCs) derived from diffusion-weighted imaging (DWI) during intracranial radiotherapy at magnetic resonance imaging-guided linear accelerators (MR-li...

    Authors: Moritz Rabe, Olaf Dietrich, Robert Forbrig, Maximilian Niyazi, Claus Belka, Stefanie Corradini, Guillaume Landry and Christopher Kurz
    Citation: Radiation Oncology 2024 19:31
  18. Intensity-modulated radiation therapy (IMRT) is considered standard of care for head and neck squamous cell carcinoma (HNSCC). Improved conformity of IMRT and smaller margins, however, have led to concerns of ...

    Authors: Paul-Henry Mackeprang, Katarina Bryjova, Astrid E. Heusel, Dominik Henzen, Melissa Scricciolo and Olgun Elicin
    Citation: Radiation Oncology 2024 19:30
  19. Percentage of positive cores involved on a systemic prostate biopsy has been established as a risk factor for adverse oncologic outcomes and is a National Comprehensive Cancer Network (NCCN) independent parame...

    Authors: Jonathan W. Lischalk, Astrid Sanchez, Vianca F. Santos, Christopher Mendez, Meredith Akerman, Todd Carpenter, Moses Tam, David Byun, David R. Wise, Anand Mahadevan, Andrew Evans, William Huang, Aaron Katz, Herbert Lepor and Jonathan A. Haas
    Citation: Radiation Oncology 2024 19:29
  20. To assess the tolerability and oncological results of chemoradiation in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction.

    Authors: Tilman Bostel, Eirini Nikolaidou, Daniel Wollschläger, Arnulf Mayer, Justus Kaufmann, Anne Hopprich, Alexander Rühle, Anca-Ligia Grosu, Jürgen Debus, Christian Fottner, Markus Moehler, Peter Grimminger, Heinz Schmidberger and Nils Henrik Nicolay
    Citation: Radiation Oncology 2024 19:28
  21. The incorporation of magnetic resonance (MR) imaging in radiotherapy (RT) workflows improves contouring precision, yet it introduces geometrical uncertainties when registered with computed tomography (CT) scan...

    Authors: Elia Rossi, Sevgi Emin, Michael Gubanski, Giovanna Gagliardi, Mattias Hedman and Fernanda Villegas
    Citation: Radiation Oncology 2024 19:27
  22. Xerostomia is one of the most common side effects in nasopharyngeal carcinoma (NPC) patients after chemoradiotherapy. To establish a Delta radiomics model for predicting xerostomia secondary to chemoradiothera...

    Authors: Mengze Wang, Yuzhen Xi, Luoyu Wang, Haonan Chen, Feng Jiang and Zhongxiang Ding
    Citation: Radiation Oncology 2024 19:26
  23. Platinum-etoposide chemotherapy combined with immune checkpoint inhibitors (ICIs) has been recommended as the first-line standard treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, the ef...

    Authors: Yueyuan Yao, Butuo Li, Ruiting Song, Linlin Yang, Bing Zou and Linlin Wang
    Citation: Radiation Oncology 2024 19:25
  24. Radioresistance is one of the barriers to developing more effective therapies against the most aggressive, triple-negative, breast cancer (TNBC) subtype. In our previous studies, we showed that inhibition of P...

    Authors: Sierra Pellizzari, Vasudeva Bhat, Harjot Athwal, David W. Cescon, Alison L. Allan and Armen Parsyan
    Citation: Radiation Oncology 2024 19:24
  25. Stereotactic ablative body radiotherapy (SABR) is an emerging treatment for patients with primary renal cell carcinoma (RCC). However, its impact on renal function is unclear. This study aimed to evaluate inci...

    Authors: Muhammad Ali, Kendrick Koo, David Chang, Phil Chan, Sheng F. Oon, Daniel Moon, Declan G. Murphy, Renu Eapen, Jeremy Goad, Nathan Lawrentschuk, Arun A. Azad, Sarat Chander, Mark Shaw, Nicholas Hardcastle and Shankar Siva
    Citation: Radiation Oncology 2024 19:23
  26. Characterizing the landscape of clinical trials including brachytherapy can provide an overview of the current status and research trends which may guide further areas of investigation.

    Authors: David Chen, Rod Parsa, Kabir Chauhan, Jelena Lukovic, Kathy Han, Amandeep Taggar and Srinivas Raman
    Citation: Radiation Oncology 2024 19:22
  27. The dosimetric effect of setup uncertainty and tissue deformations in left-sided whole-breast irradiation with complementary surface-guided radiotherapy (SGRT) and cone-beam computed tomography (CBCT) setup wa...

    Authors: M. Mankinen, T. Virén, J. Seppälä and T. Koivumäki
    Citation: Radiation Oncology 2024 19:21
  28. This study aimed to present a deep-learning network called contrastive learning-based cycle generative adversarial networks (CLCGAN) to mitigate streak artifacts and correct the CT value in four-dimensional co...

    Authors: Nannan Cao, Ziyi Wang, Jiangyi Ding, Heng Zhang, Sai Zhang, Liugang Gao, Jiawei Sun, Kai Xie and Xinye Ni
    Citation: Radiation Oncology 2024 19:20
  29. To compare the dosimetric quality of three widely used techniques for LINAC-based single-isocenter multi-target multi-fraction stereotactic radiosurgery (fSRS) with more than 20 targets: dynamic conformal arc ...

    Authors: Hyunuk Jung, Jihyung Yoon, Olga Dona Lemus, Sean Tanny, Yuwei Zhou, Michael Milano, Kenneth Usuki, Sara Hardy and Dandan Zheng
    Citation: Radiation Oncology 2024 19:19
  30. This study seeks to examine the influence of the heartbeat on the position, volume, and shape of the heart and its substructures during various breathing states. The findings of this study will serve as a valu...

    Authors: Benzhe Liang, Guanzhong Gong, Ying Tong, Lizhen Wang, Ya Su, Huadong Wang, Zhenkai Li, Hongyu Yan, Xiaohong Zhang and Yong Yin
    Citation: Radiation Oncology 2024 19:18
  31. Accelerated partial breast irradiation (APBI) is an alternative breast-conserving therapy approach where radiation is delivered in less time compared to whole breast irradiation (WBI), resulting in improved pa...

    Authors: Petr Burkon, Iveta Selingerova, Marek Slavik, Milos Holanek, Miroslav Vrzal, Oldrich Coufal, Katerina Polachova, Petr Muller, Pavel Slampa and Tomas Kazda
    Citation: Radiation Oncology 2024 19:17
  32. Ionotropic glutamate receptors α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) and N-methyl-D-aspartate receptor (NMDAR) modulate proliferation, invasion and radioresistance in glioblast...

    Authors: Thomas Büttner, Marielena K. E. Maerevoet, Frank A. Giordano, Marlon R. Veldwijk, Carsten Herskind and Arne Mathias Ruder
    Citation: Radiation Oncology 2024 19:16
  33. It is not unusual to see some parts of tissues are excluded in the field of view of CT simulation images. A typical mitigation is to avoid beams entering the missing body parts at the cost of sub-optimal plann...

    Authors: Sunmi Kim, Lulin Yuan, Siyong Kim and Tae Suk Suh
    Citation: Radiation Oncology 2024 19:15
  34. To assess the feasibility of CBCT-based adaptive intensity modulated proton therapy (IMPT) using automated planning for treatment of head and neck (HN) cancers.

    Authors: Yihang Xu, William Jin, Michael Butkus, Mariluz De Ornelas, Jonathan Cyriac, Matthew T. Studenski, Kyle Padgett, Garrett Simpson, Stuart Samuels, Michael Samuels and Nesrin Dogan
    Citation: Radiation Oncology 2024 19:13
  35. This study aimed to investigate the value of clinical, radiomic features extracted from gross tumor volumes (GTVs) delineated on CT images, dose distributions (Dosiomics), and fusion of CT and dose distributio...

    Authors: Zahra Mansouri, Yazdan Salimi, Mehdi Amini, Ghasem Hajianfar, Mehrdad Oveisi, Isaac Shiri and Habib Zaidi
    Citation: Radiation Oncology 2024 19:12
  36. Despite improvements in surgical as well as adjuvant therapies over the last decades, the prognosis for patients with glioblastoma remains poor. Five-Aminolevulinic acid (5-ALA) induced porphyrins are already ...

    Authors: Niklas Benedikt Pepper, Hans Theodor Eich, Michael Müther, Michael Oertel, Stephan Rehn, Dorothee Cäcilia Spille and Walter Stummer
    Citation: Radiation Oncology 2024 19:11
  37. Stereotactic body radiotherapy (SBRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are unfit for surgery. Some patients may experience distant metastasis. This study ...

    Authors: Lu Yu, Zhen Zhang, HeQing Yi, Jin Wang, Junyi Li, Xiaofeng Wang, Hui Bai, Hong Ge, Xiaoli Zheng, Jianjiao Ni, Haoran Qi, Yong Guan, Wengui Xu, Zhengfei Zhu, Ligang Xing, Andre Dekker…
    Citation: Radiation Oncology 2024 19:10
  38. Previous studies have demonstrated conflicting findings regarding the initial MRI patterns of radiotherapy-induced temporal lobe injury (RTLI) and the evolution of different RTLI patterns. The aim of this stud...

    Authors: Jing Hou, Yun He, Handong Li, Zhaodong Ai, Qiang Lu, Biao Zeng, Chuanmiao Xie and Xiaoping Yu
    Citation: Radiation Oncology 2024 19:9

    The Correction to this article has been published in Radiation Oncology 2024 19:41

  39. An enhanced aerobic glycolysis (“Warburg effect”) associated with an increase in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and resistance to radiation and chemotherapy. We i...

    Authors: Melissa Schwab, Ali Bashiri Dezfouli, Mohammad Khosravi, Bayan Alkotub, Lisa Bauer, Mohammad Javed Tahmasebi Birgani and Gabriele Multhoff
    Citation: Radiation Oncology 2024 19:7
  40. Training senior radiation therapists as “adapters” to manage influencers and target editing is critical in daily online adaptive radiotherapy (oART) for cervical cancer. The purpose of this study was to evalua...

    Authors: Yu Zhang, Guangyu Wang, Yankui Chang, Zhiqun Wang, Xiansong Sun, Yuliang Sun, Zheng Zeng, Yining Chen, Ke Hu, Jie Qiu, Junfang Yan and Fuquan Zhang
    Citation: Radiation Oncology 2024 19:6
  41. The study aims to enhance the efficiency and accuracy of literature reviews on normal tissue complication probability (NTCP) in head and neck cancer patients using radiation therapy. It employs meta-analysis (...

    Authors: Tsair-Fwu Lee, Yang-Wei Hsieh, Pei-Ying Yang, Chi-Hung Tseng, Shen-Hao Lee, Jack Yang, Liyun Chang, Jia-Ming Wu, Chin-Dar Tseng and Pei-Ju Chao
    Citation: Radiation Oncology 2024 19:5
  42. The aim of the present study is to examine the impact of kV-CBCT-based online adaptive radiation therapy (ART) on dosimetric parameters in comparison to image-guided-radiotherapy (IGRT) in consecutive patients...

    Authors: Maja Guberina, Nika Guberina, C. Hoffmann, A. Gogishvili, F. Freisleben, A. Herz, J. Hlouschek, T. Gauler, S. Lang, K. Stähr, B. Höing, C. Pöttgen, F. Indenkämpen, A. Santiago, A. Khouya, S. Mattheis…
    Citation: Radiation Oncology 2024 19:4
  43. Deep learning-based auto-segmentation of head and neck cancer (HNC) tumors is expected to have better reproducibility than manual delineation. Positron emission tomography (PET) and computed tomography (CT) ar...

    Authors: Yiling Wang, Elia Lombardo, Lili Huang, Michele Avanzo, Giuseppe Fanetti, Giovanni Franchin, Sebastian Zschaeck, Julian Weingärtner, Claus Belka, Marco Riboldi, Christopher Kurz and Guillaume Landry
    Citation: Radiation Oncology 2024 19:3
  44. To determine the optimal planning target volume (PTV) margins for adequate coverage by daily iterative cone-beam computed tomography (iCBCT)-guided online adaptive radiotherapy (oART) in postoperative treatmen...

    Authors: Guangyu Wang, Zhiqun Wang, Yuping Guo, Yu Zhang, Jie Qiu, Ke Hu, Jing Li, JunFang Yan and Fuquan Zhang
    Citation: Radiation Oncology 2024 19:2
  45. SBRT is an effective local treatment for patients with early-stage non-small cell lung cancer (NSCLC). This treatment is currently used in patients who have poor lung function or who decline surgery. As SBRT u...

    Authors: Ashlesha Gill, Andrew L Hirst, Pejman Rowshanfarzad, Suki Gill, Nicholas Bucknell, Joshua Dass and Mahsheed Sabet
    Citation: Radiation Oncology 2024 19:1
  46. Significant bleeding of tumor sites is a dreaded complication in oncological diseases and often results in clinical emergencies. Besides basic local and interventional procedures, an urgent radiotherapeutic ap...

    Authors: Manuel Guhlich, Teresa Esther Maag, Leif Hendrik Dröge, Andrea Hille, Sandra Donath, Stephanie Bendrich, Markus Anton Schirmer, Friedemann Nauck, Martin Leu, Joachim Riggert, Julia Gallwas and Stefan Rieken
    Citation: Radiation Oncology 2023 18:203

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