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  1. Content type: Research

    Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has ne...

    Authors: Ning Han, Xintong Lyu, Guang Li and Qiao Qiao

    Citation: Radiation Oncology 2019 14:151

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  2. Content type: Research

    The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos i...

    Authors: Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang and Lei Gao

    Citation: Radiation Oncology 2019 14:149

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  3. Content type: Methodology

    To evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.

    Authors: Mohamed Zaid, Nimit Bajaj, Hannah Burrows, Ryan Mathew, Annie Dai, Christopher T. Wilke, Stephen Palasi, Ryan Hergenrother, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David I. Rosenthal…

    Citation: Radiation Oncology 2019 14:148

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  4. Content type: Research

    There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution exp...

    Authors: Angela Y. Jia, Amol Narang, Bashar Safar, Atif Zaheer, Adrian Murphy, Nilofer S. Azad, Susan Gearhart, Sandy Fang, Jonathan Efron, Tam Warczynski, Amy Hacker-Prietz and Jeffrey Meyer

    Citation: Radiation Oncology 2019 14:147

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  5. Content type: Review

    At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated wi...

    Authors: Jingxuan Fu, Weiping Wang, Yidan Wang, Chengeng Liu and Peichang Wang

    Citation: Radiation Oncology 2019 14:146

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  6. Content type: Research

    Heterogeneous target doses are a common by-product from attempts to improve normal tissue sparing in radiosurgery treatment planning. These regions of escalated dose within the target may increase tumor contro...

    Authors: William T. Hrinivich, Todd R. McNutt and Jeffrey J. Meyer

    Citation: Radiation Oncology 2019 14:145

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  7. Content type: Research

    Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...

    Authors: Sergiu Scobioala, Christopher Kittel, Khaled Elsayad, Kai Kroeger, Michael Oertel, Laith Samhouri, Uwe Haverkamp and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:143

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  8. Content type: Research

    Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...

    Authors: Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol and David Azria

    Citation: Radiation Oncology 2019 14:142

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  9. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber

    Citation: Radiation Oncology 2019 14:141

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  10. Content type: Research

    To investigate the prognostic significance of positron emission tomography (PET) parameters from F-18 fluorodeoxyglucose (FDG) PET scans performed pre- and post- chemo-radiotherapy (CRT) for squamous cell carc...

    Authors: Michael Peter Jones, George Hruby, Ur Metser, Swetha Sridharan, Anne Capp, Mahesh Kumar, Sarah Gallagher, Natalie Rutherford, Carl Holder, Christopher Oldmeadow and Jarad Martin

    Citation: Radiation Oncology 2019 14:140

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  11. Content type: Research

    This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system.

    Authors: Jung-in Kim, Jong Min Park, Chang Heon Choi, Hyun Joon An, Yi-Jun Kim and Jin Ho Kim

    Citation: Radiation Oncology 2019 14:139

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  12. Content type: Research

    The aim of this study was to explore the impact of including or excluding the ischiorectal fossa (IRF) within the clinical target volume during neoadjuvant chemoradiotherapy (NCRT) using intensity modulated ra...

    Authors: Maxiaowei Song, Jianhao Geng, Lin Wang, Yongheng Li, Xianggao Zhu, Xiaofan Li, Lan Mi, Aiwen Wu, Yifan Peng, Yunfeng Yao, Yangzi Zhang, Hongzhi Wang, Chen Shi, Yong Cai and Weihu Wang

    Citation: Radiation Oncology 2019 14:138

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  13. Content type: Research

    To quantify the dosimetric parameters of different bone marrow sparing strategies and to determine the optimal strategy for cervical cancer patients undergoing postoperative intensity-modulated radiotherapy (I...

    Authors: Zhirong Bao, Dajiang Wang, Shupeng Chen, Min Chen, Dazhen Jiang, Chunxu Yang, Hui Liu, Jing Dai and Conghua Xie

    Citation: Radiation Oncology 2019 14:118

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  14. Content type: Research

    We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma.

    Authors: Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Takuya Kaminuma, Masaya Miyazaki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno and Takashi Nakano

    Citation: Radiation Oncology 2019 14:137

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  15. Content type: Research

    Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for the treatment of prostate cancer. However, few have reported outcomes for pros...

    Authors: Mark E. Hwang, Mark Mayeda, Maria Liz, Brenda Goode-Marshall, Lissette Gonzalez, Carl D. Elliston, Catherine S. Spina, Oscar A. Padilla, Sven Wenske and Israel Deutsch

    Citation: Radiation Oncology 2019 14:136

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  16. Content type: Research

    Along with breast-conserving surgery (BCS), adjuvant radiotherapy (RT) of patients with early breast cancer plays a crucial role in the oncologic treatment concept. Conventionally, irradiation is carried out w...

    Authors: Michael Mayinger, Kai Joachim Borm, Constantin Dreher, Hendrik Dapper, Marciana-Nona Duma, Markus Oechsner, Severin Kampfer, Stephanie Elisabeth Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:135

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  17. Content type: Review

    Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby

    Citation: Radiation Oncology 2019 14:134

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  18. Content type: Research

    The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita

    Citation: Radiation Oncology 2019 14:133

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  19. Content type: Research

    Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Authors: Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Felix Behling, Marco Skardelly, Benjamin Bender, Daniel Zips and Franziska Eckert

    Citation: Radiation Oncology 2019 14:132

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  20. Content type: Research

    To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee

    Citation: Radiation Oncology 2019 14:131

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  21. Content type: Research

    To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang

    Citation: Radiation Oncology 2019 14:129

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  22. Content type: Research

    Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

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  23. Content type: Case report

    The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

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  24. Content type: Research

    Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study pres...

    Authors: J. Visser, P. de Boer, K. F. Crama, Z. van Kesteren, C. R. N. Rasch, L. J. A. Stalpers and A. Bel

    Citation: Radiation Oncology 2019 14:126

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  25. Content type: Research

    To determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Secondly, to evaluat...

    Authors: Vincent C. Hamming, Christa Visser, Estelle Batin, Leah N. McDermott, Dianne M. Busz, Stefan Both, Johannes A. Langendijk and Nanna M. Sijtsema

    Citation: Radiation Oncology 2019 14:125

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  26. Content type: Research

    Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to...

    Authors: Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling and Andrew Ju

    Citation: Radiation Oncology 2019 14:124

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  27. Content type: Research

    Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated t...

    Authors: Stewart Mein, Ivana Dokic, Carmen Klein, Thomas Tessonnier, Till Tobias Böhlen, Guiseppe Magro, Julia Bauer, Alfredo Ferrari, Katia Parodi, Thomas Haberer, Jürgen Debus, Amir Abdollahi and Andrea Mairani

    Citation: Radiation Oncology 2019 14:123

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  28. Content type: Study protocol

    For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortene...

    Authors: Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus and Klaus Herfarth

    Citation: Radiation Oncology 2019 14:122

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  29. Content type: Research

    The boost irradiation to the tumor bed following whole-breast irradiation (WBI) reduced the risk of ipsilateral breast tumor recurrence (IBTR). However, in Japan, almost all patients with a margin ≤5 mm receiv...

    Authors: Yuka Ono, Michio Yoshimura, Kimiko Hirata, Chikako Yamauchi, Masakazu Toi, Eiji Suzuki, Masahiro Takada, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:121

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  30. Content type: Research

    Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline resectable, and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to the optim...

    Authors: Qiancheng Hu, Dan Wang, Ye Chen, Xiaofen Li, Peng Cao and Dan Cao

    Citation: Radiation Oncology 2019 14:120

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  31. Content type: Research

    Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the sti...

    Authors: Sarah Hartfiel, Matthias Häfner, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Jürgen Debus, Peter E. Huber and Nils H. Nicolay

    Citation: Radiation Oncology 2019 14:119

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  32. Content type: Research

    Primary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting with unresectable tumors, severe comorbidities, or incomplete surgical resection,...

    Authors: Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl

    Citation: Radiation Oncology 2019 14:117

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  33. Content type: Research

    Systemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), er...

    Authors: Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung

    Citation: Radiation Oncology 2019 14:116

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  34. Content type: Research

    To investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally recurrent breast cancer (RBC) after mastectomy as primary treatment.

    Authors: Gang Cai, Lu Cao, Youlia M. Kirova, Yan Feng and Jia-Yi Chen

    Citation: Radiation Oncology 2019 14:115

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  35. Content type: Review

    Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman

    Citation: Radiation Oncology 2019 14:114

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  36. Content type: Research

    To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...

    Authors: Shichao Wang, Feng Wen, Pengfei Zhang, Xin Wang and Qiu Li

    Citation: Radiation Oncology 2019 14:113

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  37. Content type: Research

    Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...

    Authors: Elisabetta Parisi, Giovenzio Genestreti, Anna Sarnelli, Giulia Ghigi, Donatella Arpa, Marco Angelo Burgio, Giampaolo Gavelli, Alice Rossi, Emanuela Scarpi, Manuela Monti, Anna Tesei, Rolando Polico and Antonino Romeo

    Citation: Radiation Oncology 2019 14:112

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  38. Content type: Research

    To calculate the individualized fraction regime (IFR) in stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) patients using the uncomplicated tumor control probability (UTCP, P+) function...

    Authors: Jia-Yang Lu, Pei-Xian Lin and Bao-Tian Huang

    Citation: Radiation Oncology 2019 14:111

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  39. Content type: Research

    Incurable inflammatory breast cancer (IBC) patients occasionally suffer from general symptoms such as breast pain, bleeding, ulceration, and discharge, and thus require palliative radiotherapy (RT). Hypofracti...

    Authors: Hoon Sik Choi, Hong Seok Jang, Ki Mun Kang and Byung-ock Choi

    Citation: Radiation Oncology 2019 14:110

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  40. Content type: Research

    The aim of this study was to compare dose-volume histogram (DVH) with dose-mass histogram (DMH) parameters for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (F...

    Authors: Markus Oechsner, Mathias Düsberg, Kai Joachim Borm, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:109

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  41. Content type: Methodology

    The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues

    Citation: Radiation Oncology 2019 14:108

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  42. Content type: Research

    Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

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  43. Content type: Research

    Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

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  44. Content type: Research

    In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2019 14:103

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  45. Content type: Research

    The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

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