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  1. Research

    Comparison of photon volumetric modulated arc therapy, intensity-modulated proton therapy, and intensity-modulated carbon ion therapy for delivery of hypo-fractionated thoracic radiotherapy

    The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion th...

    Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan and Wen-Chien Hsi

    Radiation Oncology 2017 12:132

    Published on: 15 August 2017

  2. Research

    Patterns of locoregional failure following post-operative intensity-modulated radiotherapy to oral cavity cancer: quantitative spatial and dosimetric analysis using a deformable image registration workflow

    We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT).

    Abdallah S. R. Mohamed, Andrew J. Wong, Clifton D. Fuller, Mona Kamal, Gary B. Gunn, Jack Phan, William H. Morrison, Beth M. Beadle, Heath Skinner, Stephen Y. Lai, Sean R. Quinlan-Davidson, Abdelaziz M. Belal, Ahmed G. El-Gowily, Steven J. Frank, David I. Rosenthal and Adam S. Garden

    Radiation Oncology 2017 12:129

    Published on: 15 August 2017

  3. Research

    Understanding the potentiality of accelerator based-boron neutron capture therapy for osteosarcoma: dosimetry assessment based on the reported clinical experience

    Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adju...

    Silva Bortolussi, Ian Postuma, Nicoletta Protti, Lucas Provenzano, Cinzia Ferrari, Laura Cansolino, Paolo Dionigi, Olimpio Galasso, Giorgio Gasparini, Saverio Altieri, Shin-Ichi Miyatake and Sara J. González

    Radiation Oncology 2017 12:130

    Published on: 15 August 2017

  4. Research

    Neurocognitive sparing of desktop microbeam irradiation

    Normal tissue toxicity is the dose-limiting side effect of radiotherapy. Spatial fractionation irradiation techniques, like microbeam radiotherapy (MRT), have shown promising results in sparing the normal brai...

    Soha Bazyar, Christina R. Inscoe, Thad Benefield, Lei Zhang, Jianping Lu, Otto Zhou and Yueh Z. Lee

    Radiation Oncology 2017 12:127

    Published on: 11 August 2017

  5. Research

    Risk adapted dose-intensified postoperative radiation therapy in prostate cancer patients using a simultaneous integrated boost technique applied with helical Tomotherapy

    Postoperative adjuvant radiation therapy (ART) in T3 and R1 prostate cancer as well as salvage radiation therapy (SRT) in case of postoperative biochemical failure (BF) are established treatments. Dose-intensi...

    Marcus Beck, Peter Wust, Tomasz Barelkowski, David Kaul, Alexander-Henry Thieme, Sascha Wecker, Waldemar Wlodarczyk, Volker Budach and Pirus Ghadjar

    Radiation Oncology 2017 12:125

    Published on: 10 August 2017

  6. Research

    A novel CBCT-based method for derivation of CTV-PTV margins for prostate and pelvic lymph nodes treated with stereotactic ablative radiotherapy

    Traditional CTV-PTV margin recipes are not generally applicable in the situation of stereotactic ablative radiotherapy (SABR) treatments of multiple target volumes with a single isocentre. In this work, we pre...

    Ciara A. Lyons, Raymond B. King, Sarah O.S. Osman, Stephen J. McMahon, Joe M. O’Sullivan, Alan R. Hounsell, Suneil Jain and Conor K. McGarry

    Radiation Oncology 2017 12:124

    Published on: 4 August 2017

  7. Research

    Application of the new 8th TNM staging system for non-small cell lung cancer: treated with curative concurrent chemoradiotherapy

    The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were...

    Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Jin Ho Song and Ki Mun Kang

    Radiation Oncology 2017 12:122

    Published on: 21 July 2017

  8. Research

    Clinical workflow for MR-only simulation and planning in prostate

    To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients.

    Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos and Margie Hunt

    Radiation Oncology 2017 12:119

    Published on: 17 July 2017

  9. Research

    Biomarkers of resistance to radiation therapy: a prospective study in cervical carcinoma

    Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Radiation Oncology 2017 12:120

    Published on: 17 July 2017

  10. Research

    Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation

    This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).

    Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing LV, Jun Liu, Xu-Wei Cai and Xiao-Long Fu

    Radiation Oncology 2017 12:118

    Published on: 15 July 2017

  11. Research

    Investigation of irradiated volume in linac-based brain hypo-fractionated stereotactic radiotherapy

    Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to sta...

    Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss and Young Lee

    Radiation Oncology 2017 12:117

    Published on: 14 July 2017

  12. Research

    Excellent local control and tolerance profile after stereotactic body radiotherapy of advanced hepatocellular carcinoma

    To evaluate the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of advanced hepatocellular carcinoma (HCC).

    Eleni Gkika, Michael Schultheiss, Dominik Bettinger, Lars Maruschke, Hannes Philipp Neeff, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu and Thomas Baptist Brunner

    Radiation Oncology 2017 12:116

    Published on: 12 July 2017

  13. Research

    Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy

    This retrospective analysis aimed to analyse the stability of spinal bone metastases in colorectal cancer (CRC) patients following radiotherapy (RT) by use of a validated score and to assess prognostic factors...

    Tilman Bostel, Robert Förster, Ingmar Schlampp, Tania Sprave, Thomas Bruckner, Nils Henrik Nicolay, Stefan Ezechiel Welte, Jürgen Debus and Harald Rief

    Radiation Oncology 2017 12:115

    Published on: 11 July 2017

  14. Research

    Simultaneous integrated boost therapy of carcinoma of the hypopharynx/larynx with and without flattening filter - a treatment planning and dosimetry study

    The aim of this study was to investigate if the flattening filter free (FFF) irradiation mode of a linear accelerator (linac) is advantageous as compared to the flat beam (FF) irradiation mode in intensity mod...

    Barbara Dobler, Tina Obermeier, Matthias G. Hautmann, Amine Khemissi and Oliver Koelbl

    Radiation Oncology 2017 12:114

    Published on: 5 July 2017

  15. Research

    Correlation between delivered radiation doses to the brainstem or vestibular organ and nausea & vomiting toxicity in patients with head and neck cancers – an observational clinical trial

    Today intensity modulated radiation therapy (IMRT) can be considered the standard of care in patients with head and neck tumors. IMRT treatment plans are proven to reduce acute treatment related side effects b...

    Kilian Schiller, Hanno Martin Specht, Bernhard Haller, Daniela Hallqvist, Michal Devecka, Aaron Becker von Rose, Stephanie Elisabeth Combs and Steffi Pigorsch

    Radiation Oncology 2017 12:113

    Published on: 4 July 2017

  16. Research

    Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

    Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto

    Radiation Oncology 2017 12:111

    Published on: 3 July 2017

  17. Research

    Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old

    The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arte...

    Yuichiro Hayashi, Kenji Mitsudo, Kaname Sakuma, Masaki Iida, Toshinori Iwai, Hideyuki Nakashima, Yoshiyuki Okamoto, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Izumi Koike, Masaharu Hata and Iwai Tohnai

    Radiation Oncology 2017 12:112

    Published on: 3 July 2017

  18. Review

    Systematic review of patient reported quality of life following stereotactic ablative radiotherapy for primary and metastatic liver cancer

    Stereotactic ablative radiotherapy (SABR) is a safe and effective modality in patients with liver cancer who are ineligible for other local therapies. However SABR is not current standard of practice and requi...

    Adam Mutsaers, Jeffrey Greenspoon, Cindy Walker-Dilks and Anand Swaminath

    Radiation Oncology 2017 12:110

    Published on: 29 June 2017

  19. Research

    Idelalisib may have the potential to increase radiotherapy side effects

    Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin’s lymphoma and small lymphocytic lymphoma. It is a...

    Thomas Gryc, Florian Putz, Nicole Goerig, Sonia Ziegler, Rainer Fietkau, Luitpold V. Distel and Barbara Schuster

    Radiation Oncology 2017 12:109

    Published on: 28 June 2017

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