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  1. Established prognostic models, such as the diagnosis-specific graded prognostic assessment, were not designed to specifically address very short survival. Therefore, a brain metastases-specific 30-day mortalit...

    Authors: Carsten Nieder, Luka Stanisavljevic, Siv Gyda Aanes, Bård Mannsåker and Ellinor Christin Haukland
    Citation: Radiation Oncology 2022 17:92
  2. Recently, stereotacitc radiosurgery (SRS) has been in the spotlight as an alternative therapeutic option for jugular foramen schwannomas (JFS). While most reported studies focus on the long-term efficacy and s...

    Authors: Young Goo Kim, Chang Kyu Park, Na Young Jung, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang and Won Seok Chang
    Citation: Radiation Oncology 2022 17:89
  3. Contact lens-type ocular in vivo dosimeters (CLODs) were recently developed as the first in vivo dosimeter that can be worn directly on the eye to measure the dose delivered to the lens during radiotherapy. Ho...

    Authors: Jaeman Son, Jin Dong Cho, Seongmoon Jung, Chang Heon Choi, Jong Min Park and Jung-in Kim
    Citation: Radiation Oncology 2022 17:88
  4. A new compact superconducting synchrocyclotron single-room proton solution delivers pulsed proton beams to each spot through several irradiation bursts calculated by an iterative layer delivery algorithm. Such...

    Authors: Lewei Zhao, Gang Liu, Shupeng Chen, Jiajian Shen, Weili Zheng, An Qin, Di Yan, Xiaoqiang Li and Xuanfeng Ding
    Citation: Radiation Oncology 2022 17:87
  5. This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 meta...

    Authors: Yuan Xu, Yingjie Xu, Kuo Men, Jianping Xiao and Jianrong Dai
    Citation: Radiation Oncology 2022 17:86
  6. We sought to clarify the optimal follow-up, therapeutic strategy, especially the role of reirradiation, and the diagnostic impact of isocitrate dehydrogenase (IDH) 1 and 2 mutation status in patients with radiati...

    Authors: Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Shunsuke Yanagisawa, Yukie Tamura, Daisuke Kawauchi, Miyu Kikuchi, Hiroshi Igaki, Akihiko Yoshida, Kaishi Satomi, Yuko Matsushita, Koichi Ichimura and Yoshitaka Narita
    Citation: Radiation Oncology 2022 17:85
  7. To report on the discriminative ability of a simulation Computed Tomography (CT)-based radiomics signature for predicting response to treatment in patients undergoing neoadjuvant chemo-radiation for locally ad...

    Authors: Pierluigi Bonomo, Jairo Socarras Fernandez, Daniela Thorwarth, Marta Casati, Lorenzo Livi, Daniel Zips and Cihan Gani
    Citation: Radiation Oncology 2022 17:84
  8. Adjuvant radiation therapy improves the overall survival and loco-regional control in patients with breast cancer. However, radiation-induced heart disease, which occurs after treatment from incidental radiati...

    Authors: Jaehee Chun, Jee Suk Chang, Caleb Oh, InKyung Park, Min Seo Choi, Chae-Seon Hong, Hojin Kim, Gowoon Yang, Jin Young Moon, Seung Yeun Chung, Young Joo Suh and Jin Sung Kim
    Citation: Radiation Oncology 2022 17:83
  9. Robotic linac is ideally suited to deliver hypo-fractionated radiotherapy due to its compact head and flexible positioning. The non-coplanar treatment space improves the delivery versatility but the complexity...

    Authors: Bin Liang, Ran Wei, Jianghu Zhang, Yongbao Li, Tao Yang, Shouping Xu, Ke Zhang, Wenlong Xia, Bin Guo, Bo Liu, Fugen Zhou, Qiuwen Wu and Jianrong Dai
    Citation: Radiation Oncology 2022 17:82
  10. To gain insight into the treatment outcomes for anal cancer a retrospective analysis was performed with a special emphasis on trends in outcome and toxicities over time and on treatment of elderly patients.

    Authors: Karen J. Neelis, Django M. Kip, Frank M. Speetjens and Yvette M. van der Linden
    Citation: Radiation Oncology 2022 17:81
  11. Moderately hypofractionated whole-breast radiotherapy (HFRT) has proven to be as safe and efficient as normofractionated radiotherapy (NFRT) in randomized trials resulting in major changes in clinical practice...

    Authors: Irfane Issoufaly, Claire Petit, Sébastien Guihard, Rémi Eugène, Loic Jung, Jean Baptiste Clavier, Stéphanie Servagi Vernat, Sara Bellefqih, Benjamin Verret, Naïma Bonnet, Éric Deutsch and Sofia Rivera
    Citation: Radiation Oncology 2022 17:80
  12. Inherent resistance to radio/chemotherapy is one of the major reasons for early recurrence, treatment failure, and dismal prognosis of glioblastoma. Thus, the identification of resistance driving regulators as...

    Authors: Leon Emanuel Schnöller, Valerie Albrecht, Nikko Brix, Alexander Edward Nieto, Daniel Felix Fleischmann, Maximilian Niyazi, Julia Hess, Claus Belka, Kristian Unger, Kirsten Lauber and Michael Orth
    Citation: Radiation Oncology 2022 17:79
  13. Predicting pathological complete response (pCR) in patients affected by locally advanced rectal cancer (LARC) who undergo neoadjuvant chemoradiotherapy (nCRT) is a challenging field of investigation, but many ...

    Authors: Luca Boldrini, Jacopo Lenkowicz, Lucia Clara Orlandini, Gang Yin, Davide Cusumano, Giuditta Chiloiro, Nicola Dinapoli, Qian Peng, Calogero Casà, Maria Antonietta Gambacorta, Vincenzo Valentini and Jinyi Lang
    Citation: Radiation Oncology 2022 17:78
  14. There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect ob...

    Authors: Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar…
    Citation: Radiation Oncology 2022 17:77
  15. The irradiation of breast cancer patients with included internal mammary lymph nodes challenges radiation planning with regard to robustness and protection of OARs. In this publication, a feasible hybrid radia...

    Authors: Marina Hennet, Stephan Radonic, Uwe Schneider and Matthias Hartmann
    Citation: Radiation Oncology 2022 17:76
  16. Normofractionated radiation regimes for definitive prostate cancer treatment usually extend over 7–8 weeks. Recently, moderate hypofractionation with doses per fraction between 2.2 and 4 Gy has been shown to b...

    Authors: J. Ristau, J. Hörner-Rieber, C. Buchele, S. Klüter, C. Jäkel, L. Baumann, N. Andratschke, H. Garcia Schüler, M. Guckenberger, M. Li, M. Niyazi, C. Belka, K. Herfarth, J. Debus and S. A. Koerber
    Citation: Radiation Oncology 2022 17:75
  17. There are limited data on survival prediction models in contemporary inoperable non-small cell lung cancer (NSCLC) patients. The objective of this study was to develop and validate a survival prediction model ...

    Authors: Natalie Si-Yi Lee, Jesmin Shafiq, Matthew Field, Caroline Fiddler, Suganthy Varadarajan, Senthilkumar Gandhidasan, Eric Hau and Shalini Kavita Vinod
    Citation: Radiation Oncology 2022 17:74
  18. Radiotherapy (RT) is part of the curative treatment of approximately 70% of breast cancer (BC) patients. Wide practice variation has been reported in RT dose, fractionation and its treatment planning for BC. T...

    Authors: Nansi Maliko, Marcel R. Stam, Liesbeth J. Boersma, Marie-Jeanne T. F. D. Vrancken Peeters, Michel W. J. M. Wouters, Eline KleinJan, Maurice Mulder, Marion Essers, Coen W. Hurkmans and Nina Bijker
    Citation: Radiation Oncology 2022 17:73
  19. Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for...

    Authors: Simon Deycmar, Elisabeth Mara, Sylvia Kerschbaum-Gruber, Verena Waller, Dietmar Georg and Martin Pruschy
    Citation: Radiation Oncology 2022 17:72
  20. We compared the oncological outcomes of patients who received seed brachytherapy (SEED-BT) with those who received radical prostatectomy (RP) for intermediate-risk prostate cancer.

    Authors: Hideyasu Tsumura, Nobumichi Tanaka, Tomohiko Oguchi, Takuya Owari, Yasushi Nakai, Isao Asakawa, Kazuyoshi Iijima, Haruaki Kato, Iwao Hashida, Ken-ichi Tabata, Takefumi Satoh and Hiromichi Ishiyama
    Citation: Radiation Oncology 2022 17:71
  21. To quantify the pelvic bone marrow (PBM) fat content changes receiving different radiation doses of concurrent chemoradiotherapy for cervical cancer and to determine association with peripheral blood cell counts.

    Authors: Cong Wang, Xiaohang Qin, Guanzhong Gong, Lizhen Wang, Ya Su and Yong Yin
    Citation: Radiation Oncology 2022 17:70
  22. Four-dimensional cone-beam computed tomography (4D-CBCT) can visualize moving tumors, thus adaptive radiation therapy (ART) could be improved if 4D-CBCT were used. However, 4D-CBCT images suffer from severe im...

    Authors: Keisuke Usui, Koichi Ogawa, Masami Goto, Yasuaki Sakano, Shinsuke Kyougoku and Hiroyuki Daida
    Citation: Radiation Oncology 2022 17:69
  23. Curative treatment of inoperable post-irradiation sarcoma is often challenging, especially using radiotherapy, wherein curative dose administration is difficult because the organs around the tumor have already...

    Authors: Shintaro Shiba, Masahiko Okamoto, Takashi Yanagawa, Isaku Kohama, Kei Shibuya, Shohei Okazaki, Yuhei Miyasaka, Hirotaka Chikuda and Tatsuya Ohno
    Citation: Radiation Oncology 2022 17:68
  24. To report results from our phase II study of stereotactic body radiotherapy (SBRT) delivering 36 Gy in 4 fractions for patients with localized prostate cancer.

    Authors: S. Kawakami, H. Tsumura, T. Satoh, K. Tabata, A. Sekiguchi, T. Kainuma, M. Nakano, M. Iwamura and H. Ishiyama
    Citation: Radiation Oncology 2022 17:67
  25. The use of treatment planning prostate MRI for Stereotactic Body Radiation Therapy (SBRT) is largely a standard, yet not all patients can receive MRI for a variety of clinical reasons. Thus, we aim to investig...

    Authors: Katherine Amarell, Anna Jaysing, Christopher Mendez, Jonathan A. Haas, Seth R. Blacksburg, Aaron E. Katz, Astrid Sanchez, Angela Tong, Todd Carpenter, Matthew Witten, Sean P. Collins and Jonathan W. Lischalk
    Citation: Radiation Oncology 2022 17:66
  26. Automatic prostate tumor segmentation is often unable to identify the lesion even if multi-parametric MRI data is used as input, and the segmentation output is difficult to verify due to the lack of clinically...

    Authors: Deepa Darshini Gunashekar, Lars Bielak, Leonard Hägele, Benedict Oerther, Matthias Benndorf, Anca-L. Grosu, Thomas Brox, Constantinos Zamboglou and Michael Bock
    Citation: Radiation Oncology 2022 17:65
  27. To examine the dosimetric feasibility of hypofractionated/dose escalated radiation therapy in patients with localized prostate carcinoma using simultaneous integrated boost intensity-modulated proton beam ther...

    Authors: Dalia Ahmad Khalil, Danny Jazmati, Dirk Geismar, Jörg Wulff, Christian Bäumer, Paul Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleitthoff, Sandija Plaude, Martin Bischoff, Stephan Tschirdewahn, Boris Hadaschik and Beate Timmermann
    Citation: Radiation Oncology 2022 17:64
  28. Radiotherapy is an effective regimen for cancer treatment alone or combined with chemotherapy or immunotherapy. The direct effect of radiotherapy involves radiation-induced DNA damage, and most studies have fo...

    Authors: Lei Wang, Jizong Jiang, Yuan Chen, Qingzhu Jia and Qian Chu
    Citation: Radiation Oncology 2022 17:63
  29. Prostate alignment is subject to interobserver variability in cone-beam CT (CBCT)-based soft-tissue matching. This study aims to analyze the impact of possible interobserver variability in CBCT-based soft-tiss...

    Authors: Xiangbin Zhang, Xin Wang, Xiaoyu Li, Li Zhou, Shihong Nie, Changhu Li, Xuetao Wang, Guyu Dai, Zhonghua Deng and Renming Zhong
    Citation: Radiation Oncology 2022 17:62
  30. There is currently no standard treatment for locoregional recurrence of esophageal squamous cell carcinoma (ESCC) previously treated with radiotherapy. This study aimed to assess the efficacy and safety of re-...

    Authors: Kuntian Lan and Jiaohong Chen
    Citation: Radiation Oncology 2022 17:61
  31. This study aimed at evaluating the clinical impact of full intensity-modulated radiotherapy (IMRT), hybrid IMRT (H-IMRT) and hybrid volumetric-modulated arc therapy (H-VMAT) for early-stage breast cancer with ...

    Authors: Suyan Bi, Rui Zhu and Zhitao Dai
    Citation: Radiation Oncology 2022 17:60
  32. Stereotactic body radiotherapy (SBRT) is an established local treatment method for patients with hepatic oligometastasis or oligoprogression. Liver metastases often occur in close proximity to radiosensitive o...

    Authors: P. Hoegen, K. S. Zhang, E. Tonndorf-Martini, F. Weykamp, S. Regnery, P. Naumann, K. Lang, J. Ristau, S. A. Körber, C. Dreher, C. Buchele, C. Rippke, C. K. Renkamp, K. M. Paul, L. König, C. Büsch…
    Citation: Radiation Oncology 2022 17:59
  33. The low incidence of primary mediastinal seminomas has precluded the development of clinical trials on mediastinal seminomas. We investigated the clinicopathologic characteristics, prognosis of patients with p...

    Authors: Yirui Zhai, Bo Chen, Xiaoli Feng, Kan Liu, Shulian Wang, Zhouguang Hui, Qinfu Feng, Junling Li, Zefen Xiao, Jima Lv, Yushun Gao, Yueping Liu, Hui Fang, Jianyang Wang, Lei Deng, Wenyang Liu…
    Citation: Radiation Oncology 2022 17:58
  34. The aim of the study is to identify clinical and dosimetric factors that could predict the risk of hypothyroidism in nasopharyngeal carcinoma (NPC) patients following intensity-modulated radiotherapy (IMRT).

    Authors: Ruiping Zhai, Yingchen Lyu, Mengshan Ni, Fangfang Kong, Chengrun Du, Chaosu Hu and Hongmei Ying
    Citation: Radiation Oncology 2022 17:57
  35. Interstitial pneumonia (IP) is a disease with a poor prognosis. In addition, IP patients are more likely to develop lung cancer. Since IP patients frequently develop toxicities during cancer treatment, minimal...

    Authors: Shingo Hashimoto, Hiromitsu Iwata, Yukiko Hattori, Koichiro Nakajima, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Eiko Yamamori, Kenji Akita, Jun-etsu Mizoe, Hiroyuki Ogino and Yuta Shibamoto
    Citation: Radiation Oncology 2022 17:56
  36. Previous work on Magnetic Resonance Imaging (MRI) only planning has been applied to limited treatment regions with a focus on male anatomy. This research aimed to validate the use of a hybrid multi-atlas synth...

    Authors: Laura M. O’Connor, Jason A. Dowling, Jae Hyuk Choi, Jarad Martin, Helen Warren-Forward, Haylea Richardson, Leah Best, Kate Skehan, Mahesh Kumar, Geetha Govindarajulu, Swetha Sridharan and Peter B. Greer
    Citation: Radiation Oncology 2022 17:55
  37. Prostate cancer (PCa) is known to be suitable for hypofractionated radiotherapy due to the very low α/β ratio (about 1.5–3 Gy). However, several randomized controlled trials have not shown the superiority of h...

    Authors: Ming Cui, Xian-Shu Gao, Xiaoying Li, Mingwei Ma, Xin Qi and Yuta Shibamoto
    Citation: Radiation Oncology 2022 17:54
  38. Hybrid magnetic resonance (MR)-Linac systems have recently been introduced into clinical practice. The systems allow online adaption of the treatment plan with the aim of compensating for interfractional anato...

    Authors: Lukas Nierer, Chukwuka Eze, Vanessa da Silva Mendes, Juliane Braun, Patrick Thum, Rieke von Bestenbostel, Christopher Kurz, Guillaume Landry, Michael Reiner, Maximilian Niyazi, Claus Belka and Stefanie Corradini
    Citation: Radiation Oncology 2022 17:53
  39. To summarize the characteristics of local invasion and distribution of metastatic lymph nodes in unilateral nasopharyngeal carcinoma (NPC) by magnetic resonance imaging (MRI) to provide references for the opti...

    Authors: Zheng Wu, Lin Zhang, Qian He, Feiping Li, Hongzhi Ma, Yujuan Zhou, Hui Wang and Yaqian Han
    Citation: Radiation Oncology 2022 17:52
  40. Upper tract urothelial carcinoma (UTUC) is rare and the treatment for recurrent or metastatic UTUC is unclear. We evaluated the outcomes of salvage and palliative radiotherapy (RT) and prognostic factors in UT...

    Authors: Mi Sun Kim, Woong Sub Koom, Jae Ho Cho, Se-Young Kim and Ik Jae Lee
    Citation: Radiation Oncology 2022 17:51
  41. Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a ...

    Authors: Magdalena Garbacz, Jan Gajewski, Marco Durante, Kamil Kisielewicz, Nils Krah, Renata Kopeć, Paweł Olko, Vincenzo Patera, Ilaria Rinaldi, Marzena Rydygier, Angelo Schiavi, Emanuele Scifoni, Tomasz Skóra, Agata Skrzypek, Francesco Tommasino and Antoni Rucinski
    Citation: Radiation Oncology 2022 17:50
  42. In-field dermatitis is a severe and common adverse effect of radiation therapy, that can cause significant pain and treatment interruptions in patients with squamous cell anal carcinoma (SCAC) being treated wi...

    Authors: Fabiana Hottz, Daniel Herchenhorn, Juliana Lenzi, Juliana Andrade, Vinicius Freire and Pedro Pinho
    Citation: Radiation Oncology 2022 17:49
  43. To explore clinical and dosimetric predictors of acute hematologic toxicity (HT) in cervical cancer patients treated with concurrent chemotherapy and volumetric-modulated arc therapy (VMAT).

    Authors: Xiaoyong Xiang, Zhen Ding, Qi Zeng, Lingling Feng, Chunyan Qiu, Dongjie Chen, Jiawei Lu and Ning Li
    Citation: Radiation Oncology 2022 17:48
  44. To study lymphatic recurrence distribution after radical surgery in the real world and guide clinical tumor volume delineation for regional lymph nodes during postoperative radiotherapy for lower thoracic squa...

    Authors: Rongxu Du, Songqing Fan, Xiaobin Wang, Xia Hou, Cheng Zeng, Dan Guo, Rongrong Tian, Dan Yang, Leilei Jiang, Xin Dong, Rong Yu, Huiming Yu, Dongming Li, Shuchai Zhu, Jie Li and Anhui Shi
    Citation: Radiation Oncology 2022 17:47
  45. The interplay effect of respiratory motion on the planned dose in free-breathing right-sided whole-breast irradiation (WBI) were studied by simulating hypofractionated VMAT treatment courses.

    Authors: Mikko Mankinen, Tuomas Virén, Jan Seppälä, Heikki Hakkarainen and Tuomas Koivumäki
    Citation: Radiation Oncology 2022 17:46
  46. Multimodal therapies based on surgical resection have been recommended for the treatment of adenocarcinoma of the oesophagogastric junction (AEG). We aimed to evaluate prognostic factors in AEG patients receiv...

    Authors: Rongxu Du, Jiao Ming, Jianhao Geng, Xianggao Zhu, Yangzi Zhang, Shuai Li, Zhiyan Liu, Hongzhi Wang, Zhilong Wang, Lei Tang, Xiaotian Zhang, Aiwen Wu, Zhaode Bu, Yan Yan, Zhongwu Li, Yongheng Li…
    Citation: Radiation Oncology 2022 17:45
  47. Online MR-guided radiotherapy (MRgRT) is a relatively novel advancement in the field of radiation oncology, ensuring superior soft-tissue visualisation, allowing for online plan adaptation to anatomical and fu...

    Authors: Chukwuka Eze, Elia Lombardo, Lukas Nierer, Yuqing Xiong, Maximilian Niyazi, Claus Belka, Farkhad Manapov and Stefanie Corradini
    Citation: Radiation Oncology 2022 17:43
  48. In infrared reflective (IR) marker-based hybrid real-time tumor tracking (RTTT), the internal target position is predicted with the positions of IR markers attached on the patient’s body surface using a predic...

    Authors: Dejun Zhou, Mitsuhiro Nakamura, Nobutaka Mukumoto, Hiroaki Tanabe, Yusuke Iizuka, Michio Yoshimura, Masaki Kokubo, Yukinori Matsuo and Takashi Mizowaki
    Citation: Radiation Oncology 2022 17:42
  49. The aim of this study was to clarify the association between intrafractional prostate shift and hydrogel spacer.

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Ryosuke Takenaka, Yuki Nozawa, Yuichi Watanabe, Toshikazu Imae and Osamu Abe
    Citation: Radiation Oncology 2022 17:41

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