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  1. Content type: Research

    Two prospective phase II trials were designed to assess the efficacy and safety of image-guided proton therapy (IGPT) for either medically inoperable or operable stage I non-small cell lung cancer (NSCLC). The...

    Authors: Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Yukiko Hattori, Shingo Hashimoto, Toshiyuki Toshito, Kensuke Hayashi, Kenji Akita, Fumiya Baba, Katsumi Nakamae, Jun-etsu Mizoe and Yuta Shibamoto

    Citation: Radiation Oncology 2018 13:199

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  2. Content type: Research

    In adults, a single pre-treatment four-dimensional CT (4D-CT) acquisition is often used to account for respiratory-induced target motion during radiotherapy. However, studies have indicated that a 4D-CT is not...

    Authors: Sophie C. Huijskens, Irma W. E. M. van Dijk, Jorrit Visser, Brian V. Balgobind, Coen R. N. Rasch, Tanja Alderliesten and Arjan Bel

    Citation: Radiation Oncology 2018 13:198

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  3. Content type: Research

    To compare patterns of care for elderly patients versus non-elderly patients with non-surgically treated stage III non-small cell lung cancer (NSCLC) using the National Cancer Database (NCDB). We hypothesize t...

    Authors: Eric D Miller, James L Fisher, Karl E Haglund, John C Grecula, Meng Xu-Welliver, Erin M Bertino, Kai He, Peter G Shields, David P Carbone, Terence M Williams, Gregory A Otterson and Jose G Bazan

    Citation: Radiation Oncology 2018 13:196

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  4. Content type: Research

    Adjuvant radiotherapy in advanced head and neck squamous cell cancer (HNSCC) reduces the risk of local-regional failure and most likely increases the survival rate. Patients at high risk for tumor recurrence m...

    Authors: Christiane Matuschek, Jan Haussmann, Edwin Bölke, Stephan Gripp, Patrick J. Schuler, Bálint Tamaskovics, Peter Arne Gerber, Freddy-Joel Djiepmo-Njanang, Kai Kammers, Christian Plettenberg, Bahar Anooshahr, Klaus Orth and Wilfried Budach

    Citation: Radiation Oncology 2018 13:195

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  5. Content type: Research

    Radiation therapy is the standard radical treatment for nasopharyngeal carcinoma (NPC) but also causes transient as well as long-term complications. Patients who develop severe radiation-induced brainstem inju...

    Authors: Cheng-Yun Yao, Guo-Ren Zhou, Li-Jun Wang, Jian-Hua Xu, Jin-jun Ye, Lan-Fang Zhang, Xia He, Zhen-Zhang Chen and Sheng-Fu Huang

    Citation: Radiation Oncology 2018 13:194

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  6. Content type: Research

    The SpaceOAR hydrogel is employed to limit rectal radiation dose during prostate radiotherapy. We identified a novel parameter – the product of angle θ and hydrogel volume – to quantify hydrogel placement. Thi...

    Authors: Mark E Hwang, Paul J Black, Carl D Elliston, Brian A Wolthuis, Deborah R Smith, Cheng-Chia Wu, Sven Wenske and Israel Deutsch

    Citation: Radiation Oncology 2018 13:192

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  7. Content type: Research

    Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular per...

    Authors: Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, Laura Marucci, Filomena Spasiano, Irene Terrenato and Giuseppe Sanguineti

    Citation: Radiation Oncology 2018 13:189

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  8. Content type: Research

    Modern radiotherapy offers the possibility of highly accurate tumor treatment. To benefit from this precision at its best, regular positioning verification is necessary. By the use of image-guided radiotherapy...

    Authors: Katharina Bell, Norbert Licht, Christian Rübe and Yvonne Dzierma

    Citation: Radiation Oncology 2018 13:190

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  9. Content type: Research

    Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, for non-inflammatory locally advanced breast cancer (LABC) patients, preoperative radiotherapy (pRT) ...

    Authors: Miljana Tanić, Ana Krivokuća, Milena Čavić, Jasmina Mladenović, Vesna Plesinac Karapandžić, Stephan Beck, Siniša Radulović, Snezana Susnjar and Radmila Janković

    Citation: Radiation Oncology 2018 13:193

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  10. Content type: Short report

    Pancreatic ductal adenocarcinoma has dismal prognosis. Most patients receive radiation therapy (RT), which is complicated by respiration induced organ motion in upper abdomen. The purpose of this study is to r...

    Authors: Wensha Yang, Zhaoyang Fan, Zixin Deng, Jianing Pang, Xiaoming Bi, Benedick A Fraass, Howard Sandler, Debiao Li and Richard Tuli

    Citation: Radiation Oncology 2018 13:191

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  11. Content type: Research

    There is currently no worldwide consensus for the management of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). We evaluated the efficacy of stereotactic body radiotherapy (SBRT) as the ...

    Authors: Yongjie Shui, Wei Yu, Xiaoqiu Ren, Yinglu Guo, Jing Xu, Tao Ma, Bicheng Zhang, Jianjun Wu, Qinghai Li, Qiongge Hu, Li Shen, Xueli Bai, Tingbo Liang and Qichun Wei

    Citation: Radiation Oncology 2018 13:188

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  12. Content type: Research

    Physicians and physicists are expected to contribute to patient safety and quality improvement (QI) in Radiation Oncology (RO), but prior studies suggest that training for this may be inadequate. RO and medica...

    Authors: Matthew B. Spraker, Matthew J. Nyflot, Kristi R. G. Hendrickson, Stephanie Terezakis, Shannon E. Fogh, Gabrielle M. Kane, Eric C. Ford and Jing Zeng

    Citation: Radiation Oncology 2018 13:186

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  13. Content type: Research

    Despite dosimetric benefits of volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation (RNI), low dose to the thoracic structures rema...

    Authors: Vishruta A. Dumane, Kitwadee Saksornchai, Ying Zhou, Linda Hong, Simon Powell and Alice Y. Ho

    Citation: Radiation Oncology 2018 13:187

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  14. Content type: Research

    The patterns of nodal relapse in submandibular gland carcinoma (SMGC) patients treated with postoperative radiotherapy (PORT) remain unclear. This study aims to investigate the nodal failure patterns and the u...

    Authors: Cheng-En Hsieh, Li-Yu Lee, Yung-Chih Chou, Kang-Hsing Fan, Ngan-Ming Tsang, Joseph Tung-Chieh Chang, Hung-Ming Wang, Shu-Hang Ng, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang and Chien-Yu Lin

    Citation: Radiation Oncology 2018 13:184

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  15. Content type: Research

    Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was...

    Authors: M. Oertel, S. Scobioala, K. Kroeger, A. Baehr, L. Stegger, U. Haverkamp, M. Schäfers and H.-T. Eich

    Citation: Radiation Oncology 2018 13:185

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  16. Content type: Correction

    Following the publication of this article [1], the authors noticed that figures 2, 3, 4 and 5 were in the incorrect order and thus had incorrect captions.

    Authors: Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock…

    Citation: Radiation Oncology 2018 13:183

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    The original article was published in Radiation Oncology 2018 13:159

  17. Content type: Correction

    Following publication of the original article [1], the authors reported that one of the authors’ names is spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original p...

    Authors: Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, Robert Förster, Niccolò Giaj-Levra, Nikolaos Koutsouvelis, Aurelie Bertaut, Michel Zimmermann, Giuseppe Roberto D’Agostino, Filippo Alongi, Matthias Guckenberger and Raymond Miralbell

    Citation: Radiation Oncology 2018 13:182

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    The original article was published in Radiation Oncology 2018 13:166

  18. Content type: Research

    Concurrent chemoradiotherapy is considered curative intent treatment for patients with non-operative esophageal cancer. Radiation-induced heart damage receives much attention. We performed repeated four-dimens...

    Authors: Xue Wang, Jin-Zhi Wang, Jian-Bin Li, Ying-Jie Zhang, Feng-Xiang Li, Wei Wang, Yan-Luan Guo, Qian Shao, Min Xu, Xi-Jun Liu and Yue Wang

    Citation: Radiation Oncology 2018 13:181

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  19. Content type: Research

    This study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transpla...

    Authors: Dong-Yun Kim, Il Han Kim, Sung-Soo Yoon, Hyoung Jin Kang, Hee Young Shin and Hyun-Cheol Kang

    Citation: Radiation Oncology 2018 13:180

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  20. Content type: Research

    We report prospectively captured clinical toxicity and patient reported outcomes in a single institutional cohort of patients treated for prostate cancer with proton beam therapy (PBT). This is the largest rep...

    Authors: Howard J. Lee Jr, Meghan W. Macomber, Matthew B. Spraker, Stephen R. Bowen, Daniel S. Hippe, Angela Fung, Kenneth J. Russell, George E. Laramore, Ramesh Rengan, Jay Liao, Smith Apisarnthanarax and Jing Zeng

    Citation: Radiation Oncology 2018 13:179

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  21. Content type: Research

    A novel remote method for external dosimetric TPS-planned auditing of intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for clinical trials using electronic portal imaging dev...

    Authors: Narges Miri, Kimberley Legge, Kim Colyvas, Joerg Lehmann, Philip Vial, Alisha Moore, Monica Harris and Peter B. Greer

    Citation: Radiation Oncology 2018 13:178

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  22. Content type: Research

    To compare the efficacies and toxicities of intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) or conventional two-dimensional radiotherapy (2D-RT) for definitive tr...

    Authors: Yanzhu Lin, Kai Chen, Zhiyuan Lu, Lei Zhao, Yalan Tao, Yi Ouyang and Xinping Cao

    Citation: Radiation Oncology 2018 13:177

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  23. Content type: Research

    To measure the absorbed dose rate to water and penumbra of a Gamma Knife® (GK) using a polymethyl metacrylate (PMMA) phantom.

    Authors: Jae Pil Chung, Young Min Seong, Tae Yeon Kim, Yona Choi, Tae Hoon Kim, Hyun Joon Choi, Chul Hee Min, Hamza Benmakhlouf, Kook Jin Chun and Hyun-Tai Chung

    Citation: Radiation Oncology 2018 13:176

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  24. Content type: Research

    Interfractional organ position variation might differ for abdominal organs and this could have consequences for defining safety margins. Therefore, the purpose of this study is to quantify interfractional posi...

    Authors: Sophie C. Huijskens, Irma W. E. M. van Dijk, Jorrit Visser, Brian V. Balgobind, D. te Lindert, Coen R. N. Rasch, Tanja Alderliesten and Arjan Bel

    Citation: Radiation Oncology 2018 13:173

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  25. Content type: Research

    To analyze the clinical outcome of elderly women with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interstitial hig...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Lucile Montagné, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi

    Citation: Radiation Oncology 2018 13:174

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  26. Content type: Research

    To evaluate clinical outcomes of simultaneous integrated boost (SIB) - intensity modulated radiotherapy (RT) in patients with non metastatic anal cancer compared to those of a set of patients treated with 3-di...

    Authors: Pierfrancesco Franco, Berardino De Bari, Francesca Arcadipane, Alexis Lepinoy, Manuela Ceccarelli, Gabriella Furfaro, Massimiliano Mistrangelo, Paola Cassoni, Martina Valgiusti, Alessandro Passardi, Andrea Casadei Gardini, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Andrea Evangelista, Umberto Ricardi…

    Citation: Radiation Oncology 2018 13:172

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  27. Content type: Research

    To investigate the treatment failure pattern and factors influencing locoregional recurrence of esophageal squamous cell carcinoma (ESCC) and examine patient survival with re-irradiation (re-RT) after primary ...

    Authors: Liang Hong, Yun-xia Huang, Qing-yang Zhuang, Xue-qing Zhang, Li-rui Tang, Kai-xin Du, Xiao-yi Lin, Bu-hong Zheng, Shao-li Cai, Jun-xin Wu and Jin-luan Li

    Citation: Radiation Oncology 2018 13:171

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  28. Content type: Research

    Automated treatment planning and/or optimization systems (ATPS) are in the process of broad clinical implementation aiming at reducing inter-planner variability, reducing the planning time allocated for the op...

    Authors: J. Krayenbuehl, M. Zamburlini, S. Ghandour, M. Pachoud, S. Tanadini-Lang, J. Tol, M. Guckenberger and W. F. A. R. Verbakel

    Citation: Radiation Oncology 2018 13:170

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    The Correction to this article has been published in Radiation Oncology 2018 13:225

  29. Content type: Research

    The cranial border of the target volume (TV) in rectal cancer patients treated with neoadjuvant chemoradiation (nCRT) is mostly defined at the level of L5/S1. However, current studies have shown that relapse c...

    Authors: Hendrik Dapper, Markus Oechsner, Stefan Münch, Kai Borm, Jan Peeken, Michael Mayinger, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:169

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  30. Content type: Research

    Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective ...

    Authors: Yvonne Dzierma, Katharina Mikulla, Patrick Richter, Katharina Bell, Patrick Melchior, Frank Nuesken and Christian Rübe

    Citation: Radiation Oncology 2018 13:168

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  31. Content type: Case report

    Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the cent...

    Authors: Jackson M. May, Mark R. Waddle, Daniel H. Miller, William C. Stross, Tasneem A. Kaleem, Byron C. May, Robert C. Miller, Liuyan Jiang, Gerald W. Strong, Daniel M. Trifiletti, Kaisorn L. Chaichana, Ronald Reimer, Han W. Tun and Jennifer L. Peterson

    Citation: Radiation Oncology 2018 13:167

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  32. Content type: Research

    Stereotactic Body Radiotherapy (SBRT) is an ablative dose delivery technique which requires the highest levels of precision and accuracy. Modeling dose to a lung treatment volume has remained a complex and cha...

    Authors: Dennis J. Mohatt, Tianjun Ma, David B. Wiant, Naveed M. Islam, Jorge Gomez, Anurag K. Singh and Harish K. Malhotra

    Citation: Radiation Oncology 2018 13:165

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  33. Content type: Study protocol

    Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with localized prostate cancer. Promising results in terms of disease control and toxicity have been reported with 4 to 5...

    Authors: Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, Robert Förster, Niccolò Giaj-Levra, Nikolaos Koutsouvelis, Aurelie Bertaut, Michel Zimmermann, Giuseppe Roberto D’Agostino, Filippo Alongi, Matthias Guckenberger and Raymond Miralbell

    Citation: Radiation Oncology 2018 13:166

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    The Correction to this article has been published in Radiation Oncology 2018 13:182

  34. Content type: Research

    A wide application of ultrasound for radiation therapy has been hindered by a few issues such as skin and target deformations due to probe pressure, optical tracking disabilities caused by irregular surfaces a...

    Authors: Heejung Kim, Ah Ram Chang, Sungwoo Cho and Sung-Joon Ye

    Citation: Radiation Oncology 2018 13:164

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  35. Content type: Research

    This study clarified the mechanical performance of volumetric modulated arc therapy (VMAT) plans for prostate cancer generated with a commercial knowledge-based treatment planning (KBP) and whether KBP system ...

    Authors: Mikoto Tamura, Hajime Monzen, Kenji Matsumoto, Kazuki Kubo, Masakazu Otsuka, Masahiro Inada, Hiroshi Doi, Kazuki Ishikawa, Kiyoshi Nakamatsu, Iori Sumida, Hirokazu Mizuno, Do-Kun Yoon and Yasumasa Nishimura

    Citation: Radiation Oncology 2018 13:163

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  36. Content type: Research

    To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeo...

    Authors: Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock…

    Citation: Radiation Oncology 2018 13:159

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    The Correction to this article has been published in Radiation Oncology 2018 13:183

  37. Content type: Research

    Radiotherapy is one of the standard treatments for cutaneous lymphoma and Total Skin Electrons Beam Irradiation (TSEBI) is generally used to treat diffuse cutaneous lymphoma and some cases of localized disease...

    Authors: Michela Buglione, Luigi Spiazzi, Mauro Urpis, Liliana Baushi, Rossella Avitabile, Nadia Pasinetti, Paolo Borghetti, Luca Triggiani, Sara Pedretti, Federica Saiani, Alfredo Fiume, Diana Greco, Stefano Ciccarelli, Alessia Polonini, Renzo Moretti and Stefano Maria Magrini

    Citation: Radiation Oncology 2018 13:158

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  38. Content type: Research

    Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validit...

    Authors: Georgia K. B. Halkett, Charles Adam Wigley, Samar M Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie McFadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel and Nigel Spry

    Citation: Radiation Oncology 2018 13:162

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  39. Content type: Research

    Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-i...

    Authors: Yue Zhou, Xiaowu Sheng, Feiyan Deng, Hui Wang, Liangfang Shen, Yong Zeng, Qianxi Ni, Shibin Zhan and Xiao Zhou

    Citation: Radiation Oncology 2018 13:160

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  40. Content type: Short report

    The reporting of adverse effects is an integral aspect of a hospital quality improvement (QI) program with the goal of improving care for current and future patients. We report the results of our experience tr...

    Authors: Varun Chowdhry, Pamela Jangro, Saveli Goldberg, Nolan Gagne, Shelley Chabot, Gary Proulx and Cocav Rauwerdink

    Citation: Radiation Oncology 2018 13:161

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  41. Content type: Research

    The demand for dose verification during treatment has risen with the increasing use of intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in modern radiation therapy. This...

    Authors: So-Yeon Park, Jong Min Park, Jung-in Kim, Sungyoung Lee and Chang Heon Choi

    Citation: Radiation Oncology 2018 13:156

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  42. Content type: Research

    A recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in...

    Authors: Wei Ge, Huilin Xu, Yafei Yan and Dedong Cao

    Citation: Radiation Oncology 2018 13:155

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  43. Content type: Research

    This study aimed to analyse the frequency and clinical relevance of sacral insufficiency fractures (SIFs) after high-dose carbon-ion based irradiation of sacral chordomas.

    Authors: Tilman Bostel, Nils Henrik Nicolay, Thomas Welzel, Thomas Bruckner, Matthias Mattke, Sati Akbaba, Tanja Sprave, Jürgen Debus and Matthias Uhl

    Citation: Radiation Oncology 2018 13:154

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  44. Content type: Research

    In this pooled 2-center series LINAC radiosurgery (SRS) has been applied as a treatment option for a subset of refractory trigeminal neuralgia (TN) patients. This study approached to retrospectively assess the...

    Authors: Ali Rashid, Bogdan Pintea, Thomas M. Kinfe, Gunnar Surber, Klaus Hamm and Jan P. Boström

    Citation: Radiation Oncology 2018 13:153

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  45. Content type: Study protocol

    In an oligometastatic setting, metastasis-directed treatment could render patients disease free, possibly for a protracted interval. Stereotactic ablative radiotherapy (SABR) is one of the treatment modalities...

    Authors: Carole Mercier, Piet Dirix, Paul Meijnders, Peter Vermeulen, Steven Van Laere, Hilde Debois, Philippe Huget and Dirk Verellen

    Citation: Radiation Oncology 2018 13:152

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  46. Content type: Research

    Emerging hypofractionated prostate radiotherapy regimens require solutions for accurate target tracking during beam delivery. The goal of this study is to evaluate the performance of the Clarity ultrasound mon...

    Authors: Bin Han, Mohammad Najafi, David T. Cooper, Martin Lachaine, Rie von Eyben, Steven Hancock and Dimitre Hristov

    Citation: Radiation Oncology 2018 13:151

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  47. Content type: Research

    Patient-specific distortions, particularly near tissue/air interfaces, require assessment for magnetic resonance (MR) only radiation treatment planning (RTP). However, patients are dynamic due to changes in ph...

    Authors: Carri Glide-Hurst, Siamak Nejad-Davarani, Steffen Weiss, Weili Zheng, Indrin J. Chetty and Steffen Renisch

    Citation: Radiation Oncology 2018 13:149

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