Skip to main content

Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

Page 6 of 25

  1. Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer.

    Authors: Yosuke Takakusagi, Hiroyuki Katoh, Kio Kano, Wataru Anno, Keisuke Tsuchida, Nobutaka Mizoguchi, Itsuko Serizawa, Daisaku Yoshida and Tadashi Kamada

    Citation: Radiation Oncology 2020 15:127

    Content type: Research

    Published on:

  2. To evaluate the impact of primary tumor radiotherapy on survival in patients with unresectable metastatic rectal or rectosigmoid cancer.

    Authors: Gang Wang, Wenling Wang, Haijie Jin, Hongmin Dong, Weiwei Chen, Xiaokai Li, Guodong Li and Leilei Li

    Citation: Radiation Oncology 2020 15:126

    Content type: Research

    Published on:

  3. Anal cancer is a rare disease, which might be the reason for the “one size fits all” approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contempo...

    Authors: Martin P. Nilsson, Erik D. Nilsson, Anders Johnsson, Otilia Leon, Adalsteinn Gunnlaugsson and Jonas Scherman

    Citation: Radiation Oncology 2020 15:125

    Content type: Research

    Published on:

  4. To investigate the loco-regional progression-free survival (LPFS) of intensity-modulated radiotherapy (IMRT) with different fraction sizes for locally advanced non-small-cell lung cancer (LANSCLC), and to appl...

    Authors: Bo Qiu, Qi Wen Li, Xin Lei Ai, Bin Wang, Jian Huan, Zheng Fei Zhu, Gen Hua Yu, Ming Ji, Hai Hang Jiang, Cheng Li, Jun Zhang, Li Chen, Jin Yu Guo, Yin Zhou and Hui Liu

    Citation: Radiation Oncology 2020 15:124

    Content type: Research

    Published on:

  5. To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).

    Authors: Ryo Toya, Tetsuo Saito, Kohsei Yamaguchi, Tomohiko Matsuyama, Takahiro Watakabe, Tadashi Matsumoto, Ryoji Yoshida, Akiyuki Hirosue, Daizo Murakami, Yorihisa Orita, Hideki Nakayama and Natsuo Oya

    Citation: Radiation Oncology 2020 15:123

    Content type: Research

    Published on:

  6. Patients with left-sided breast cancer frequently receive deep inspiration breath-hold (DIBH) radiotherapy to reduce the risk of cardiac side effects. The aim of the present study was to analyze intra-breath-h...

    Authors: D. Reitz, F. Walter, S. Schönecker, P. Freislederer, M. Pazos, M. Niyazi, G. Landry, F. Alongi, E. Bölke, C. Matuschek, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2020 15:121

    Content type: Research

    Published on:

  7. After esophagectomy, adjuvant chemotherapy (S + CT) and adjuvant chemoradiotherapy (S + CRT) can improve survival in patients with node-positive resectable esophageal cancer. However, we are not aware of any s...

    Authors: Qifeng Wang, Jinyi Lang, Tao Li, Lin Peng, Wei Dai, Yinchun Jiang, Tianpeng Xie, Qiang Fang, Yi Wang, Lei Wu, Bangrong Cao and Yongtao Han

    Citation: Radiation Oncology 2020 15:119

    Content type: Research

    Published on:

  8. Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Surgical resection is the standard treatment for localized ACC, but the local recurrence remains high. Adjuvant radiation (ART) has be...

    Authors: Jiawei Zhu, Ziye Zheng, Jing Shen, Xin Lian, Zheng Miao, Jie Shen and Fuquan Zhang

    Citation: Radiation Oncology 2020 15:118

    Content type: Research

    Published on:

  9. Patients with left-sided breast cancer have an increased risk of cardiovascular disease (CVD) after radiotherapy (RT). While the awareness of cardiac toxicity has increased enormously over the last decade, the...

    Authors: Aurélie Gaasch, Stephan Schönecker, Cristoforo Simonetto, Markus Eidemüller, Montserrat Pazos, Daniel Reitz, Maya Rottler, Philipp Freislederer, Michael Braun, Rachel Würstlein, Nadia Harbeck, Maximilian Niyazi, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:117

    Content type: Research

    Published on:

  10. Sarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including pati...

    Authors: Romain Mallet, Romain Modzelewski, Justine Lequesne, Sorina Mihailescu, Pierre Decazes, Hugues Auvray, Ahmed Benyoucef, Fréderic Di Fiore, Pierre Vera, Bernard Dubray and Sébastien Thureau

    Citation: Radiation Oncology 2020 15:116

    Content type: Research

    Published on:

  11. Stereotactic radiosurgery (SRS) is an effective treatment for trigeminal neuralgia (TN). Nevertheless, a proportion of patients will experience recurrence and treatment-related sensory disturbances. In order t...

    Authors: Alfredo Conti, Gueliz Acker, Antonio Pontoriero, Juliane Hardt, Anne Kluge, Alberto Cacciola, Giuseppe Iatì, Markus Kufeld, Volker Budach, Peter Vajkoczy, Giancarlo Beltramo, Stefano Pergolizzi, Achille Bergantin, Franziska Loebel, Silvana Parisi, Carolin Senger…

    Citation: Radiation Oncology 2020 15:115

    Content type: Research

    Published on:

  12. We evaluated whether pre- and mid-treatment metabolic tumor volume (MTV) predicts per lesion local recurrence (LR) in patients treated with definitive radiation therapy (RT, dose≥60 Gy) for locally advanced no...

    Authors: Michael S. Binkley, Julie L. Koenig, Mehr Kashyap, Michael Xiang, Yufei Liu, Quaovi Sodji, Peter G. Maxim, Maximilian Diehn, Billy W. Loo Jr and Michael F. Gensheimer

    Citation: Radiation Oncology 2020 15:114

    Content type: Research

    Published on:

  13. The number of nonagenarian cancer patients (≥ 90 years) is continuously increasing, and radiotherapy is performed in a relevant proportion of patients, as surgery and chemotherapy are often not feasible for th...

    Authors: Tanja Sprave, Alexander Rühle, Raluca Stoian, Alina Weber, Constantinos Zamboglou, Carsten Nieder, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:113

    Content type: Research

    Published on:

  14. To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.

    Authors: Hans Geinitz, Carsten Nieder, Lukas Kocik, Christine Track, Johann Feichtinger, Theresa Weingartner, Kurt Spiegl, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Dietmar H. Seewald, Reinhold Függer, Andreas Shamiyeh, Andreas L. Petzer, David Kiesl and Josef Hammer

    Citation: Radiation Oncology 2020 15:111

    Content type: Research

    Published on:

  15. Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-en...

    Authors: Gustavo R. Sarria, Vera Petrova, Frederik Wenz, Yasser Abo-Madyan, Elena Sperk and Frank A. Giordano

    Citation: Radiation Oncology 2020 15:110

    Content type: Research

    Published on:

  16. Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with ...

    Authors: Dan Wang, Chongshun Liu, Yuan Zhou, Tingyu Yan, Chenglong Li, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Cenap Güngör and Yuqiang Li

    Citation: Radiation Oncology 2020 15:107

    Content type: Research

    Published on:

  17. Structure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promis...

    Authors: Mark H. F. Savenije, Matteo Maspero, Gonda G. Sikkes, Jochem R. N. van der Voort van Zyp, Alexis N. T. J. Kotte, Gijsbert H. Bol and Cornelis A. T. van den Berg

    Citation: Radiation Oncology 2020 15:104

    Content type: Research

    Published on:

  18. Radiotherapy treatment of head and neck cancer affects local arteries and increases the risk of stroke. This study aimed at a closer characterization of this damage and its development in time with a longitudi...

    Authors: Cristoforo Simonetto, Michael Mayinger, Thamer Ahmed, Kai Borm, Pavel Kundrát, Steffi Pigorsch, Jan Christian Kaiser and Stephanie E. Combs

    Citation: Radiation Oncology 2020 15:102

    Content type: Research

    Published on:

  19. Although controversial, there are data suggesting that clinical parameters can predict the probability of sphincter preserving procedures in rectal cancer. The purpose of this study was to investigate the asso...

    Authors: Richard Partl, Marton Magyar, Eva Hassler, Tanja Langsenlehner and Karin Sigrid Kapp

    Citation: Radiation Oncology 2020 15:99

    Content type: Research

    Published on:

  20. Over the past years, several treatment regimens have been recommended for elderly patients with glioblastoma (GBM), ranging from ultrahypofractionated radiotherapy (RT) over monochemotherapy (ChT) to combined ...

    Authors: Christoph Straube, Kerstin A. Kessel, Stefanie Antoni, Jens Gempt, Bernhard Meyer, Juergen Schlegel, Friederike Schmidt-Graf and Stephanie E. Combs

    Citation: Radiation Oncology 2020 15:97

    Content type: Research

    Published on:

  21. Skull base chordomas are rare and heterogeneously behaving tumors. Though still classified as benign they can grow rapidly, are locally aggressive, and have the potential to metastasize. To adapt the treatment...

    Authors: Anna-Lena Hottinger, Beat Bojaxhiu, Frank Ahlhelm, Marc Walser, Barbara Bachtiary, Stefan Zepter, Tony Lomax, Alessia Pica and Damien C. Weber

    Citation: Radiation Oncology 2020 15:96

    Content type: Research

    Published on:

  22. To explore the efficacy and safety of Transcatheter rectal arterial chemoembolization with oxaliplatin and S-1 concurrent chemoradiotherapy as neoadjuvant therapy for locally advanced rectal cancer.

    Authors: Bo Yang, Jinlu Shan, Yan Feng, Nan Dai, Mengxia Li, Chuan Chen, Shengyong He, Ge Wang, Hualiang Xiao, Chunxue Li and Dong Wang

    Citation: Radiation Oncology 2020 15:94

    Content type: Research

    Published on:

  23. During these last years, new agents have dramatically improved the survival of the metastatic patients. Oligometastases represent a continuous field of interest in which the integration of metastases-directed ...

    Authors: Rosario Mazzola, Barbara Alicja Jereczek-Fossa, Davide Franceschini, Slavisa Tubin, Andrea Riccardo Filippi, Maria Tolia, Andrea Lancia, Giuseppe Minniti, Stefanie Corradini, Stefano Arcangeli, Marta Scorsetti and Filippo Alongi

    Citation: Radiation Oncology 2020 15:92

    Content type: Review

    Published on:

  24. Esophagitis influences quality of life and might cause treatment interruption and hospitalization. Previous studies of risk factors focused on curative treatment for non-small cell lung cancer (NSCLC), which o...

    Authors: Carsten Nieder, Kristian S. Imingen, Bård Mannsåker, Rosalba Yobuta and Ellinor Haukland

    Citation: Radiation Oncology 2020 15:91

    Content type: Research

    Published on:

  25. Prognostication tools for early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) are currently lacking. The purpose of this study was to develop and external...

    Authors: Sarah Baker, Katerina Bakunina, Marloes Duijm, Mischa S. Hoogeman, Robin Cornelissen, Imogeen Antonisse, John Praag, Wilma D. Heemsbergen and Joost Jan Nuyttens

    Citation: Radiation Oncology 2020 15:89

    Content type: Research

    Published on:

  26. Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are wi...

    Authors: M. Unterrainer, C. Eze, H. Ilhan, S. Marschner, O. Roengvoraphoj, N. S. Schmidt-Hegemann, F. Walter, W. G. Kunz, P. Munck af Rosenschöld, R. Jeraj, N. L. Albert, A. L. Grosu, M. Niyazi, P. Bartenstein and C. Belka

    Citation: Radiation Oncology 2020 15:88

    Content type: Review

    Published on:

  27. Deep learning-based algorithms have demonstrated enormous performance in segmentation of medical images. We collected a dataset of multiparametric MRI and contour data acquired for use in radiosurgery, to eval...

    Authors: Khaled Bousabarah, Maximilian Ruge, Julia-Sarita Brand, Mauritius Hoevels, Daniel Rueß, Jan Borggrefe, Nils Große Hokamp, Veerle Visser-Vandewalle, David Maintz, Harald Treuer and Martin Kocher

    Citation: Radiation Oncology 2020 15:87

    Content type: Research

    Published on:

  28. Current chemoradiation regimens for locally advanced cervical cancer are fairly uniform despite a profound diversity of treatment response and recurrence patterns. The wide range of treatment responses and pro...

    Authors: Shin-Hyung Park, Myong Hun Hahm, Bong Kyung Bae, Gun Oh Chong, Shin Young Jeong, Sungdae Na, Sungmoon Jeong and Jae-Chul Kim

    Citation: Radiation Oncology 2020 15:86

    Content type: Research

    Published on:

  29. To evaluate the longitudinal changes of quality of life (QoL) and survival in patients with nasopharyngeal carcinoma (NPC) treated by volumetric-modulated arc therapy (VMAT) versus intensity-modulated radiothe...

    Authors: Tai-Lin Huang, Ming-Hsien Tsai, Hui-Ching Chuang, Chih-Yen Chien, Yu-Tsai Lin, Wen-Ling Tsai and Fu-Min Fang

    Citation: Radiation Oncology 2020 15:84

    Content type: Research

    Published on:

  30. Glioblastoma is a rapidly proliferating tumor. Patients bear an inferior prognosis with a median survival time of 14-16 months. Proliferation and repopulation are a major resistance promoting factor for conven...

    Authors: N. Guberina, C. Pöttgen, S. Kebir, L. Lazaridis, C. Scharmberg, W. Lübcke, M. Niessen, M. Guberina, B. Scheffler, V. Jendrossek, R. Jabbarli, D. Pierscianek, U. Sure, T. Schmidt, C. Oster, P. Hau…

    Citation: Radiation Oncology 2020 15:83

    Content type: Research

    Published on:

  31. Hypofractionated stereotactic radiotherapy (HFSRT) is indicated for large brain metastases (BM) or proximity to critical organs (brainstem, chiasm, optic nerves, hippocampus). The primary aim of this study was...

    Authors: Laurence Mengue, Aurélie Bertaut, Louise Ngo Mbus, Mélanie Doré, Myriam Ayadi, Karen Clément-Colmou, Line Claude, Christian Carrie, Cécile Laude, Ronan Tanguy, Julie Blanc and Marie-Pierre Sunyach

    Citation: Radiation Oncology 2020 15:82

    Content type: Research

    Published on:

  32. Treatment for local and locoregional recurrence or second head-and-neck (H&N) cancers after previous radiotherapy is challenging, and re-irradiation carries a significantly increased risk for radiotherapy-rela...

    Authors: Alexander Rühle, Tanja Sprave, Tobias Kalckreuth, Raluca Stoian, Erik Haehl, Constantinos Zamboglou, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:81

    Content type: Research

    Published on:

  33. To analyze management and outcomes following (chemo)radiation therapy in patients with cervical lymph node metastases from an unknown primary site (CCUP) in a large single-center cohort.

    Authors: Tanja Sprave, Alexander Rühle, Katharina Hees, Tobias Kalckreuth, Vivek Verma, Raluca Stoian, Constantinos Zamboglou, Jens Pfeiffer, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:80

    Content type: Research

    Published on:

  34. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide biomarkers of the outcome of locally-advanced cervical carcinoma (LACC). There is, however, no agreement on how DCE-MR recordings shou...

    Authors: Kjersti V. Lund, Trude G. Simonsen, Gunnar B. Kristensen and Einar K. Rofstad

    Citation: Radiation Oncology 2020 15:79

    Content type: Research

    Published on:

  35. Several studies investigating the role of intraoperative radiotherapy (IORT) in the treatment of resectable pancreatic cancer (PC) have been published; however, their results remain inconsistent. By conducting...

    Authors: Liang Jin, Ning Shi, Shiye Ruan, Baohua Hou, Yiping Zou, Xiongfeng Zou, Haosheng Jin and Zhixiang Jian

    Citation: Radiation Oncology 2020 15:76

    Content type: Review

    Published on:

  36. The improvement of survival outcomes and the reduction of toxicities for esophageal squamous cell carcinoma (SCC) are still needed. We conducted a pilot study of concurrent chemoradiotherapy with weekly doceta...

    Authors: Qi Liu, Yi Xia, Yun Chen, Junhua Zhang, Jiaying Deng and Kuaile Zhao

    Citation: Radiation Oncology 2020 15:75

    Content type: Research

    Published on:

  37. The COVID-19 pandemic is challenging modern radiation oncology. At University Hospitals, we have a mandate to offer high-end treatments to all cancer patients. However, in times of crisis we must learn to prio...

    Authors: Stephanie E. Combs, Claus Belka, Maximilian Niyazi, Stefanie Corradini, Steffi Pigorsch, Jan Wilkens, Anca L. Grosu, Matthias Guckenberger, Ute Ganswindt and Denise Bernhardt

    Citation: Radiation Oncology 2020 15:74

    Content type: Review

    Published on:

  38. To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients.

    Authors: Lucas C. Mendez, Ananth Ravi, Kevin Martell, Hamid Raziee, Yasir Alayed, Matt Wronski, Moti Paudel, Elizabeth Barnes, Amandeep Taggar, C. S. Wong and Eric Leung

    Citation: Radiation Oncology 2020 15:73

    Content type: Research

    Published on:

  39. The optimal adjuvant treatment for stage III endometrial cancer in the era of modern radiotherapy remains undefined. We investigated the benefit of adjuvant radiotherapy for women who underwent optimal resecti...

    Authors: Jenny Ling-Yu Chen, Yu-Sen Huang, Chao-Yuan Huang, Che-Yu Hsu, Keng-Hsueh Lan, Wen-Fang Cheng and Sung-Hsin Kuo

    Citation: Radiation Oncology 2020 15:72

    Content type: Research

    Published on:

  40. Radiation therapy is an integral part of the multidisciplinary management of breast cancer. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in...

    Authors: Jan Haussmann, Stefanie Corradini, Carolin Nestle-Kraemling, Edwin Bölke, Freddy Joel Djiepmo Njanang, Bálint Tamaskovics, Klaus Orth, Eugen Ruckhaeberle, Tanja Fehm, Svjetlana Mohrmann, Ioannis Simiantonakis, Wilfried Budach and Christiane Matuschek

    Citation: Radiation Oncology 2020 15:71

    Content type: Review

    Published on:

  41. The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.

    Authors: Meng Ni, Aijun Jiang, Wenju Liu, Yanxing Sheng, Haiyan Zeng, Ning Liu, Qingxiao Gao, Yong Wang, Jinming Yu and Shuanghu Yuan

    Citation: Radiation Oncology 2020 15:70

    Content type: Research

    Published on:

  42. Unity Elekta is a unique magnetic resonance (MR)-linac that conjugates a 1.5 Tesla MR unit with a 7 MV flattening filter free accelerator.A prospective observational study for the clinical use of Elekta Unity ...

    Authors: Filippo Alongi, Michele Rigo, Vanessa Figlia, Francesco Cuccia, Niccolò Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Rosario Mazzola

    Citation: Radiation Oncology 2020 15:69

    Content type: Research

    Published on:

  43. We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and ...

    Authors: Ling Zhou, Jia Chen, Wei Shen, Zheng-Lu Chen, Shuang Huang, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu and Yuan-Yuan Chen

    Citation: Radiation Oncology 2020 15:68

    Content type: Research

    Published on:

Annual Journal Metrics