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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. In unresectable hepatocellular carcinoma several local ablative treatments are available. Among others, radiation based treatments such as stereotactic body radiotherapy (SBRT) and high-dose rate interstitial ...

    Authors: Franziska Walter, Lukas Nierer, Maya Rottler, Anna Sophie Duque, Helmut Weingandt, Justus Well, Roel Shpani, Guillaume Landry, Max Seidensticker, Florian Streitparth, Jens Ricke, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2021 16:86

    Content type: Research

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  2. the aim of this study is to perform an external validation for the Candiolo nomogram, a predictive algorithm of biochemical and clinical recurrences in prostate cancer patients treated by radical Radiotherapy,...

    Authors: Domenico Gabriele, Alessia Guarneri, Sara Bartoncini, Fernando Munoz, Matteo Tamponi, Filippo Russo, Georgios Stamatakos, Caterina Guiot, Daniele Regge and Umberto Ricardi

    Citation: Radiation Oncology 2021 16:85

    Content type: Research

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  3. To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) of liver metastases based on a patient individual longitudinal dosimetric analysis.

    Authors: Michael Mayinger, Roman Ludwig, Sebastian M. Christ, Riccardo Dal Bello, Alex Ryu, Nienke Weitkamp, Matea Pavic, Helena Garcia Schüler, Lotte Wilke, Matthias Guckenberger, Jan Unkelbach, Stephanie Tanadini-Lang and Nicolaus Andratschke

    Citation: Radiation Oncology 2021 16:84

    Content type: Research

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  4. Positron emission tomography-(PET) has evolved as a powerful tool to guide treatment for prostate cancer (PC). The aim of this survey was to evaluate the acceptance and use of PET—especially with prostate-spec...

    Authors: Marco M. E. Vogel, Sabrina Dewes, Eva K. Sage, Michal Devecka, Jürgen E. Gschwend, Matthias Eiber, Stephanie E. Combs and Kilian Schiller

    Citation: Radiation Oncology 2021 16:82

    Content type: Research

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  5. The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the ...

    Authors: J-J Stelmes, E. Vu, V. Grégoire, C. Simon, E. Clementel, J. Kazmierska, W. Grant, M. Ozsahin, M. Tomsej, L. Vieillevigne, C. Fortpied, E. C. Hurkmans, A. Branquinho, N. Andratschke, F. Zimmermann and D.-C. Weber

    Citation: Radiation Oncology 2021 16:81

    Content type: Research

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  6. Radiomics is a new technology to noninvasively predict survival prognosis with quantitative features extracted from medical images. Most radiomics-based prognostic studies of non-small-cell lung cancer (NSCLC)...

    Authors: Yuto Sugai, Noriyuki Kadoya, Shohei Tanaka, Shunpei Tanabe, Mariko Umeda, Takaya Yamamoto, Kazuya Takeda, Suguru Dobashi, Haruna Ohashi, Ken Takeda and Keiichi Jingu

    Citation: Radiation Oncology 2021 16:80

    Content type: Research

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  7. The optimal dose and fractionation scheme of stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) remains unclear due to different tolerated liver volumes and degrees of cirrhosis. In ...

    Authors: Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng and Le-Qun Li

    Citation: Radiation Oncology 2021 16:79

    Content type: Research

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  8. Liver compresses are frequently used in integrative medicine as supportive therapy during cancer treatment in order to reduce fatigue. We performed a pilot study to test whether the external application of yar...

    Authors: Pirus Ghadjar, Wiebke Stritter, Irina von Mackensen, Felix Mehrhof, Clara Foucré, Vincent H. Ehrhardt, Marcus Beck, Pimrapat Gebert, Goda Kalinauskaite, Jacqueline S. Luchte, Carmen Stromberger, Volker Budach, Angelika Eggert and Georg Seifert

    Citation: Radiation Oncology 2021 16:76

    Content type: Research

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  9. Despite modern treatment techniques, radiotherapy (RT) in patients with head and neck cancer (HNC) may be associated with high rates of acute and late treatment-related toxicity. The most effective approach to...

    Authors: Thomas Held, Christopher Herpel, Franz Sebastian Schwindling, Leo Christ, Kristin Lang, Sebastian Regnery, Tanja Eichkorn, Adriane Hommertgen, Cornelia Jaekel, Johannes Krisam, Julius Moratin, Jan Mrosek, Karl Metzger, Karim Zaoui, Tracy Moutsis, Semi Harrabi…

    Citation: Radiation Oncology 2021 16:75

    Content type: Study protocol

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  10. To generate and validate state-of-the-art radiomics models for prediction of radiation-induced lung injury and oncologic outcome in non-small cell lung cancer (NSCLC) patients treated with robotic stereotactic...

    Authors: Khaled Bousabarah, Oliver Blanck, Susanne Temming, Maria-Lisa Wilhelm, Mauritius Hoevels, Wolfgang W. Baus, Daniel Ruess, Veerle Visser-Vandewalle, Maximilian I. Ruge, Harald Treuer and Martin Kocher

    Citation: Radiation Oncology 2021 16:74

    Content type: Research

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  11. Despite complete surgical resection brain metastases are at significant risk of local recurrence without additional radiation therapy. Traditionally, the addition of postoperative whole brain radiotherapy (WBR...

    Authors: Giuseppe Minniti, Maximilian Niyazi, Nicolaus Andratschke, Matthias Guckenberger, Joshua D. Palmer, Helen A. Shih, Simon S. Lo, Scott Soltys, Ivana Russo, Paul D. Brown and Claus Belka

    Citation: Radiation Oncology 2021 16:73

    Content type: Review

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  12. The study objective was to establish the local effect model (LEM) rectum constraints for 12-, 8-, and 4-fraction carbon-ion radiotherapy (CIRT) in patients with localized prostate carcinoma (PCA) using microdo...

    Authors: Weiwei Wang, Ping Li, Yinxiangzi Sheng, Zhijie Huang, Jingfang Zhao, Zhengshan Hong, Kambiz Shahnazi, Guo-Liang Jiang and Qing Zhang

    Citation: Radiation Oncology 2021 16:72

    Content type: Research

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  13. Clinical target volume (CTV) contouring guidelines are frequently developed through studies in which experts contour the CTV for a representative set of cases for a given treatment site and the consensus CTVs ...

    Authors: Liam S. P. Lawrence, Lee C. L. Chin, Rachel W. Chan, Timothy K. Nguyen, Arjun Sahgal, Chia-Lin Tseng and Angus Z. Lau

    Citation: Radiation Oncology 2021 16:71

    Content type: Methodology

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  14. Previous studies have found that patients with subclinical interstitial lung disease (ILD) are highly susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy. In the present study...

    Authors: Fangjuan Li, Hui Liu, Hongyu Wu, Shixiong Liang and Yaping Xu

    Citation: Radiation Oncology 2021 16:70

    Content type: Research

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  15. Patients with unresectable advanced cutaneous squamous cell carcinoma (cSCC) are generally treated with palliative intent. Immune checkpoint blockade has significant activity in the palliative setting in patie...

    Authors: Charles Lin, Trishna Ballah, Michelle Nottage, Karen Hay, Benjamin Chua, Lizbeth Kenny, Paul Thomas, Michele Teng, Jacqui Keller, Trang Le, Jennifer Edmunds and Brett Hughes

    Citation: Radiation Oncology 2021 16:69

    Content type: Study protocol

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  16. Stereotactic body radiotherapy (SBRT) is a promising ablative modality for hepatocellular carcinoma (HCC) especially for those with small-sized or early-stage tumors. This study aimed to synthesize available d...

    Authors: Yanyan Long, Yan Liang, Shujie Li, Jing Guo, Ying Wang, Yan Luo and Yongzhong Wu

    Citation: Radiation Oncology 2021 16:68

    Content type: Research

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  17. Definitive chemoradiotherapy (CRT) is standard of care for nasopharyngeal carcinoma. Due to the tumor localization and concomitant platinum-based chemotherapy, hearing impairment is a frequent complication, wi...

    Authors: Enkelejda Lamaj, Erwin Vu, Janita E. van Timmeren, Chiara Leonardi, Louise Marc, Izabela Pytko, Matthias Guckenberger and Panagiotis Balermpas

    Citation: Radiation Oncology 2021 16:64

    Content type: Research

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  18. There is a large lack of evidence for optimal treatment in oligometastatic head and neck cancer and it is especially unclear which patients benefit from radical local treatment of all tumour sites.

    Authors: Thomas Weissmann, Daniel Höfler, Markus Hecht, Sabine Semrau, Marlen Haderlein, Irina Filimonova, Benjamin Frey, Christoph Bert, Sebastian Lettmaier, Konstantinos Mantsopoulos, Heinrich Iro, Rainer Fietkau and Florian Putz

    Citation: Radiation Oncology 2021 16:62

    Content type: Research

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  19. Stereotactic radiosurgery (SRS) has been recognized as a first-line treatment option for small to moderate sized vestibular schwannoma (VS). Our aim is to evaluate the impact of SRS doses and other patient and...

    Authors: Ekin Ermiş, Lukas Anschuetz, Dominic Leiser, Robert Poel, Andreas Raabe, Peter Manser, Daniel M. Aebersold, Marco Caversaccio, Georgios Mantokoudis, Janine Abu-Isa, Franca Wagner and Evelyn Herrmann

    Citation: Radiation Oncology 2021 16:61

    Content type: Research

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  20. Primary cardiac tumors are an extremely rare disease with limited prognosis. The treatment of choice is surgery. Other treatment options include chemotherapy and radiation therapy, which historically represent...

    Authors: Stefanie Corradini, Rieke von Bestenbostel, Angela Romano, Adrian Curta, Dorit Di Gioia, Lorenzo Placidi, Maximilian Niyazi and Luca Boldrini

    Citation: Radiation Oncology 2021 16:60

    Content type: Case report

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  21. This prospective phase I/II trial assessed feasibility and efficacy of dose-escalated definitive chemoradiation after induction chemotherapy in locally advanced esophageal cancer. Primary study endpoint was lo...

    Authors: C. Pöttgen, E. Gkika, M. Stahl, J. Abu Jawad, T. Gauler, S. Kasper, T. Trarbach, K. Herrmann, N. Lehmann, K.-H. Jöckel, H. Lax and M. Stuschke

    Citation: Radiation Oncology 2021 16:59

    Content type: Research

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  22. To analyze the pattern of failure in relation to pre-treatment [18F] FDG-PET/CT uptake in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive radio-chemotherapy (RT-CHT).

    Authors: C. Pisani, L. Vigna, F. Mastroleo, G. Loi, V. Amisano, L. Masini, L. Deantonio, P. Aluffi Valletti, G. Sacchetti and M. Krengli

    Citation: Radiation Oncology 2021 16:57

    Content type: Research

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  23. The current status of German residency training in the field of radiation oncology is provided and compared to programmes in other countries. In particular, we present the DEGRO-Academy within the internationa...

    Authors: Marcel Büttner, Nils Cordes, Tobias Gauer, Daniel Habermehl, Gunther Klautke, Oliver Micke, Matthias Mäurer, Jan Sokoll, Esther Gera Cornelia Troost, Hans Christiansen and Maximilian Niyazi

    Citation: Radiation Oncology 2021 16:55

    Content type: Research

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  24. Systematic pelvic lymphadenectomy or whole pelvic irradiation is recommended for the patients with stage IB1 cervical cancer. However, the precise pattern of lymphatic tumor spread in cervical cancer is unknow...

    Authors: Jing Cai, Xiaoqi He, Hongbo Wang, Weihong Dong, Yuan Zhang, Jing Zhao, Kay C. Willborn, Bangxing Huang, Zehua Wang and Ping Jiang

    Citation: Radiation Oncology 2021 16:54

    Content type: Research

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  25. Patients with lung cancer and interstitial lung disease treated with radiotherapy are at risk of developing radiation pneumonitis. However, the association between interstitial lung abnormalities (ILAs) and ra...

    Authors: Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon and Toshiaki Takahashi

    Citation: Radiation Oncology 2021 16:52

    Content type: Research

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  26. Several radiotherapeutic approaches for patients with oligotopic malignant liver lesions unfit for surgical resection exist. The most advanced competitive techniques are high-dose-rate (HDR) brachytherapy, Cyb...

    Authors: Peter Wust, Marcus Beck, Robert Dabrowski, Oliver Neumann, Sebastian Zschaeck, David Kaul, Dominik P. Modest, Carmen Stromberger, Bernhard Gebauer and Pirus Ghadjar

    Citation: Radiation Oncology 2021 16:51

    Content type: Research

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  27. Due to improved imaging sensitivity, the term “oligometastatic” prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy (MDT). There are two types of r...

    Authors: Paul Rogowski, Mack Roach III, Nina-Sophie Schmidt-Hegemann, Christian Trapp, Rieke von Bestenbostel, Run Shi, Alexander Buchner, Christian Stief, Claus Belka and Minglun Li

    Citation: Radiation Oncology 2021 16:50

    Content type: Review

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  28. The purpose of this study was to assess whether thoracic radiotherapy (TRT) combined with chemotherapy (CHT) showed promising anti-tumour activity in extensive-stage small cell lung cancer (ES-SCLC), to explor...

    Authors: Jinmin Han, Chengrui Fu and Baosheng Li

    Citation: Radiation Oncology 2021 16:47

    Content type: Research

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  29. The value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET)-radiomics in the outcome assessment of patients with recurrent glioblastoma (rGBM) has not been evaluated until now. The...

    Authors: Montserrat Carles, Ilinca Popp, Michael Maximilian Starke, Michael Mix, Horst Urbach, Tanja Schimek-Jasch, Franziska Eckert, Maximilian Niyazi, Dimos Baltas and Anca L. Grosu

    Citation: Radiation Oncology 2021 16:46

    Content type: Research

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  30. In breast cancer patients receiving radiotherapy (RT), accurate target delineation and reduction of radiation doses to the nearby normal organs is important. However, manual clinical target volume (CTV) and or...

    Authors: Seung Yeun Chung, Jee Suk Chang, Min Seo Choi, Yongjin Chang, Byong Su Choi, Jaehee Chun, Ki Chang Keum, Jin Sung Kim and Yong Bae Kim

    Citation: Radiation Oncology 2021 16:44

    Content type: Research

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  31. To evaluate the effect of prophylactic irradiation of internal mammary lymph nodes in breast cancer patients.

    Authors: Sicong Jia, Zhikun Liu, Jun Zhang, Chenguang Zhao, Longyu Zhu, Jie Kong, Huina Han, Yuguang Shang, Dongxing Shen and Xuejuan Duan

    Citation: Radiation Oncology 2021 16:42

    Content type: Review

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  32. The exact rate and relevant risk factors of radiation pneumonitis (RP) for non-small-cell cancer (NSCLC) patients treated with the combination of epidermal growth factor receptor-tyrosine kinase inhibitors (EG...

    Authors: Wenxiao Jia, Qianqian Gao, Min Wang, Ji Li, Wang Jing, Jinming Yu and Hui Zhu

    Citation: Radiation Oncology 2021 16:41

    Content type: Research

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  33. Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) and additional salvage external beam radiotherapy (EBRT) after tumor rec...

    Authors: Indrawati Hadi, Daniel Reitz, Raphael Bodensohn, Olarn Roengvoraphoj, Stefanie Lietke, Maximilian Niyazi, Jörg-Christian Tonn, Claus Belka, Niklas Thon and Silke Birgit Nachbichler

    Citation: Radiation Oncology 2021 16:40

    Content type: Research

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  34. Stereotactic body radiation therapy (SBRT) is an established therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). Many elderly patients are medically inoperable owing to comorbiditi...

    Authors: Kenta Watanabe, Kuniaki Katsui, Soichiro Sugiyama, Kotaro Yoshio, Masahiro Kuroda, Takao Hiraki, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa

    Citation: Radiation Oncology 2021 16:39

    Content type: Research

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  35. Primary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in delayed presentation, and the therapeutic effects of multimodal treatment di...

    Authors: Juntao Ran, Guofeng Qu, Xiaohua Chen and Da Zhao

    Citation: Radiation Oncology 2021 16:38

    Content type: Review

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  36. The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2–3 mm. Nowadays, MRI is used for target delineati...

    Authors: Karin Goudschaal, F. Beeksma, M. Boon, M. Bijveld, J. Visser, K. Hinnen and Z. van Kesteren

    Citation: Radiation Oncology 2021 16:37

    Content type: Research

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  37. Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO...

    Authors: Giuseppe Minniti, Maximilian Niyazi, Filippo Alongi, Piera Navarria and Claus Belka

    Citation: Radiation Oncology 2021 16:36

    Content type: Review

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  38. The impact of adjuvant radiotherapy (RT) on atypical meningioma (AM) underwent a gross total resection (GTR) remains unclear, showing conflicting results from various studies. The objective of this study was t...

    Authors: Se-Woong Chun, Kyung Min Kim, Min-Sung Kim, Ho Kang, Yun-Sik Dho, Youngbeom Seo, Jin Wook Kim, Yong Hwy Kim and Chul-Kee Park

    Citation: Radiation Oncology 2021 16:34

    Content type: Review

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  39. Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate can...

    Authors: Lindsay S. Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E. Citrin, Peter Choyke and Baris Turkbey

    Citation: Radiation Oncology 2021 16:32

    Content type: Research

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  40. The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is...

    Authors: Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko and Mohammad K. Khan

    Citation: Radiation Oncology 2021 16:31

    Content type: Research

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  41. To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academi...

    Authors: Mark J. Stevens, Simon West, Gregory Gard, Christopher Renaud, David Nevell, Stephanie Roderick and Andrew Le

    Citation: Radiation Oncology 2021 16:29

    Content type: Research

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  42. Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is a current pandemic. We initiated a program of systematic SARS-CoV-2 polymerase chain reaction (PCR) testing in all asymptomatic patients re...

    Authors: Roshan S. Prabhu, Reshika Dhakal, Amy S. Hicks, James McBride, Alicia L. Patrick, Christopher D. Corso, Tomain Murphy, Melissa Thonen, Edward H. Lipford, Derek Raghavan and Stuart H. Burri

    Citation: Radiation Oncology 2021 16:28

    Content type: Research

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  43. Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices...

    Authors: Stefanie Corradini, Maximilian Niyazi, Dirk Verellen, Vincenzo Valentini, Seán Walsh, Anca-L. Grosu, Kirsten Lauber, Amato Giaccia, Kristian Unger, Jürgen Debus, Bradley R. Pieters, Matthias Guckenberger, Suresh Senan, Wilfried Budach, Roland Rad, Julia Mayerle…

    Citation: Radiation Oncology 2021 16:27

    Content type: Review

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  44. Segmentation is a crucial step in treatment planning that directly impacts dose distribution and optimization. The aim of this study was to evaluate the inter-individual variability of common cranial organs at...

    Authors: Guillaume Vogin, Liza Hettal, Clarisse Bartau, Juliette Thariat, Marie-Virginie Claeys, Guillaume Peyraga, Paul Retif, Ulrike Schick, Delphine Antoni, Zsuzsa Bodgal, Frederic Dhermain and Loic Feuvret

    Citation: Radiation Oncology 2021 16:26

    Content type: Research

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  45. This meta-analysis evaluated the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

    Authors: Xiaoyong Xiang, Zhen Ding, Lingling Feng and Ning Li

    Citation: Radiation Oncology 2021 16:24

    Content type: Review

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  46. Radiation therapy and chemoradiation therapy play a major role in the definitive management of esophageal cancer. Survival in esophageal cancer patients is still relatively poor, mostly due to high rates of lo...

    Authors: J. Ristau, M. Thiel, S. Katayama, I. Schlampp, K. Lang, M. F. Häfner, K. Herfarth, J. Debus and S. A. Koerber

    Citation: Radiation Oncology 2021 16:23

    Content type: Research

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  47. For meningiomas, complete resection is recommended as first-line treatment while stereotactic radiosurgery (SRS) is established for meningiomas of smaller size considered inoperable. If the patient´s medical c...

    Authors: Maximilian I. Ruge, Juman Tutunji, Daniel Rueß, Eren Celik, Christian Baues, Harald Treuer, Martin Kocher and Stefan Grau

    Citation: Radiation Oncology 2021 16:22

    Content type: Research

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