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Radiation Oncology

Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Case report

    Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment op...

    Authors: Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu and Thomas Brunner

    Citation: Radiation Oncology 2018 13:28

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  2. Content type: Research

    We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy.

    Authors: Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, Jin-Beom Chung, Keun-Yong Eom, Jae-Sung Kim, Chae-Yong Kim, Young Ho Park, Yu Jung Kim and In Ah Kim

    Citation: Radiation Oncology 2018 13:29

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  3. Content type: Research

    We evaluated dynamic changes in 18F–borono-L-phenylalanine (18F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neut...

    Authors: Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai and Jun Itami

    Citation: Radiation Oncology 2018 13:4

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  4. Content type: Research

    Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melano...

    Authors: Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck and David Kaul

    Citation: Radiation Oncology 2018 13:3

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  5. Content type: Research

    Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are...

    Authors: Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer and Christoph Henkenberens

    Citation: Radiation Oncology 2017 12:165

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  6. Content type: Research

    Stereotactic body radiotherapy (SBRT) is an emerging modality for definitive treatment of Hepatocellular carcinoma (HCC).

    Authors: Assaf Moore, Michal Cohen-Naftaly, Anna Tobar, Yulia Kundel, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eytan Mor, Michal Sarfaty, Dimitri Bragilovski, Ran Ben Hur, Noa Gordon, Salomon M. Stemmer and Aaron M. Allen

    Citation: Radiation Oncology 2017 12:163

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  7. Content type: Research

    Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body r...

    Authors: Michael C. Repka, Nima Aghdam, Shaan K. Kataria, Lloyd Campbell, Simeng Suy, Sean P. Collins, Eric Anderson, Jonathan W. Lischalk and Brian T. Collins

    Citation: Radiation Oncology 2017 12:162

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  8. Content type: Research

    The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of...

    Authors: Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa and Yasutaka Nakano

    Citation: Radiation Oncology 2017 12:160

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  9. Content type: Research

    Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investi...

    Authors: Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G. Moros, Matthew B. Schabath, Zhaoxiang Ye, Robert J. Gillies and Thomas J. Dilling

    Citation: Radiation Oncology 2017 12:158

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  10. Content type: Research

    The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.

    Authors: Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer and Piet Ost

    Citation: Radiation Oncology 2017 12:157

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  11. Content type: Research

    The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy ...

    Authors: Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe and Keiichi Nakagawa

    Citation: Radiation Oncology 2017 12:156

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  12. Content type: Review

    Since the discovery of X-rays at the end of the 19th century, medical imageology has progressed for 100 years, and medical imaging has become an important auxiliary tool for clinical diagnosis. With the launch of...

    Authors: Bojiang Chen, Rui Zhang, Yuncui Gan, Lan Yang and Weimin Li

    Citation: Radiation Oncology 2017 12:154

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  13. Content type: Research

    Stereotactic body radiotherapy (SBRT) for vertebral metastases has emerged as a promising technique, offering high rates of symptom relief and local control combined with low risk of toxicity. Nonetheless, loc...

    Authors: Johannes Roesch, John B.C. Cho, Daniel K. Fahim, Peter C. Gerszten, John C. Flickinger, Inga S. Grills, Maha Jawad, Ronald Kersh, Daniel Letourneau, Frederick Mantel, Arjun Sahgal, John H. Shin, Brian Winey and Matthias Guckenberger

    Citation: Radiation Oncology 2017 12:153

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  14. Content type: Research

    Efficacy of stereotactic body radiotherapy (SBRT) in stage I non–small-cell lung cancer (NSCLC) has almost been established. In Japan, the protocol of 48 Gy in 4 fractions over 4 days has been most often emplo...

    Authors: Akifumi Miyakawa, Yuta Shibamoto, Fumiya Baba, Yoshihiko Manabe, Taro Murai, Chikao Sugie, Takeshi Yanagi and Taiki Takaoka

    Citation: Radiation Oncology 2017 12:152

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  15. Content type: Research

    Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation thera...

    Authors: Salman A. Eraj, Mona K. Jomaa, Crosby D. Rock, Abdallah S. R. Mohamed, Blaine D. Smith, Joshua B. Smith, Theodora Browne, Luke C. Cooksey, Bowman Williams, Brandi Temple, Kathryn E. Preston, Jeremy M. Aymard, Neil D. Gross, Randal S. Weber, Amy C. Hessel, Renata Ferrarotto…

    Citation: Radiation Oncology 2017 12:150

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    The Correction to this article has been published in Radiation Oncology 2017 12:186

  16. Content type: Research

    The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high ris...

    Authors: Fady B. Geara, Muhammad Bulbul, Raja B. Khauli, Therese Y. Andraos, Mirna Abboud, Abdelatif Al Mousa, Nasim Sarhan, Ahmed Salem, Hamza Ghatasheh, Anoud Alnsour, Zeina Ayoub, Ibrahim Abu Gheida, Maya Charafeddine, Mohammed Shahait, Ali Shamseddine, Rami Abu Gheida…

    Citation: Radiation Oncology 2017 12:149

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  17. Content type: Research

    Hypoxic cancer cells are thought to be radioresistant and could impact local recurrence after radiotherapy (RT). One of the major hypoxic imaging modalities is [18F]fluoromisonidazole positron emission tomography...

    Authors: Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Yuji Kuge, Hao Peng, Nagara Tamaki and Hiroki Shirato

    Citation: Radiation Oncology 2017 12:148

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  18. Content type: Research

    To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer and inter-modality variability.

    Authors: Espen Rusten, Bernt Louni Rekstad, Christine Undseth, Ghazwan Al-Haidari, Bettina Hanekamp, Eivor Hernes, Taran Paulsen Hellebust, Eirik Malinen and Marianne Grønlie Guren

    Citation: Radiation Oncology 2017 12:147

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  19. Content type: Research

    Neoadjuvant chemoradiotherapy following surgery has recently become a standard therapy. The purpose of the present study was to determine the effectiveness and toxicity of re-irradiation for oligo-recurrence i...

    Authors: Keiichi Jingu, Yuzuru Niibe, Hideomi Yamashita, Kuniaki Katsui, Toshihiko Matsumoto, Tomohiro Nishina and Atsuro Terahara

    Citation: Radiation Oncology 2017 12:146

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  20. Content type: Research

    Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause ...

    Authors: Mio Nakajima, Naoyoshi Yamamoto, Kazuhiko Hayashi, Masataka Karube, Daniel K Ebner, Wataru Takahashi, Makoto Anzai, Kenji Tsushima, Yuji Tada, Koichiro Tatsumi, Tadaaiki Miyamoto, Hiroshi Tsuji, Takehiko Fujisawa and Tadashi Kamada

    Citation: Radiation Oncology 2017 12:144

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