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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. To report dosimetry and early adverse effects, aesthetic, and patient-reported outcomes of a prospective study of 3-fraction pencil-beam scanning (PBS) proton accelerated partial irradiation (APBI).

    Authors: Robert W. Mutter, Krishan R. Jethwa, Karthik Gonuguntla, Nicholas B. Remmes, Thomas J. Whitaker, Tina J. Hieken, Kathryn J. Ruddy, Lisa A. McGee, Kimberly S. Corbin and Sean S. Park

    Citation: Radiation Oncology 2019 14:211

    Content type: Research

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  2. Small cell carcinoma of the esophagus (SCCE) is characterized by its progressive feature and poor prognosis. There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to charac...

    Authors: Baoqing Chen, Han Yang, Huali Ma, Qiaoqiao Li, Bo Qiu, Yonghong Hu and Yujia Zhu

    Citation: Radiation Oncology 2019 14:210

    Content type: Research

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  3. Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also be...

    Authors: Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki and Susumu Kanazawa

    Citation: Radiation Oncology 2019 14:209

    Content type: Research

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  4. Despite increasing clinical data suggest that internal mammary node (IMN) irradiation would improve local-regional control and overall survival in breast cancer, its role remains controversial due to increased...

    Authors: Yujie Wang, Weixiang Qi, Haoping Xu, Miao Zhang, Yimin Han, Jiayi Chen and Cheng Xu

    Citation: Radiation Oncology 2019 14:208

    Content type: Research

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  5. To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiat...

    Authors: Xiyin Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, Lin Kong and Jiade J. Lu

    Citation: Radiation Oncology 2019 14:206

    Content type: Research

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  6. Some patients experience oligo-progression during androgen receptor targeted therapy (ARTT) treatments. This progression might not indicate a real systemic drug resistance, but a selective monoclonal resistanc...

    Authors: Maurizio Valeriani, Luca Marinelli, Serena Macrini, Chiara Reverberi, Anna Maria Aschelter, Vitaliana De Sanctis, Paolo Marchetti, Lidia Tronnolone and Mattia Falchetto Osti

    Citation: Radiation Oncology 2019 14:205

    Content type: Research

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  7. Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction can be detected early after BC RT with g...

    Authors: Valentin Walker, Olivier Lairez, Olivier Fondard, Atul Pathak, Baptiste Pinel, Christian Chevelle, Denis Franck, Gaëlle Jimenez, Jérémy Camilleri, Loïc Panh, David Broggio, Sylvie Derreumaux, Marie-Odile Bernier, Dominique Laurier, Jean Ferrières and Sophie Jacob

    Citation: Radiation Oncology 2019 14:204

    Content type: Research

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  8. To determine the prognostic effect of adjuvant radiation and clinicopathological variables in surgically treated patients with small cell carcinoma of the cervix (SCCC).

    Authors: Ting Shen, Yan-hui Jiang, Yao-yao Zou, Fang-fang Qiu, Xing-sheng Qiu and Kai-yun You

    Citation: Radiation Oncology 2019 14:203

    Content type: Research

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  9. The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment...

    Authors: Thomas Held, Paul Windisch, Sati Akbaba, Kristin Lang, Benjamin Farnia, Jakob Liermann, Denise Bernhardt, Peter Plinkert, Christian Freudlsperger, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg

    Citation: Radiation Oncology 2019 14:202

    Content type: Research

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  10. This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hF...

    Authors: Conti Alfredo, Senger Carolin, Acker Güliz, Kluge Anne, Pontoriero Antonio, Cacciola Alberto, Pergolizzi Stefano, Germanò Antonino, Badakhshi Harun, Kufeld Markus, Meinert Franziska, Nguyen Phuong, Loebel Franziska, Vajkoczy Peter, Budach Volker and Kaul David

    Citation: Radiation Oncology 2019 14:201

    Content type: Research

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  11. The purpose of this study was to evaluate the outcomes of elderly patients (aged ≥75 years) with newly diagnosed glioblastoma (GBM), who were treated with hypofractionated radiotherapy comprising 45 Gy in 15 f...

    Authors: Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura and Yoshitaka Narita

    Citation: Radiation Oncology 2019 14:200

    Content type: Research

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  12. Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this stu...

    Authors: Steffen Auerswald, Stephan Schreml, Robert Meier, Alexandra Blancke Soares, Maximilian Niyazi, Sebastian Marschner, Claus Belka, Martin Canis and Frank Haubner

    Citation: Radiation Oncology 2019 14:199

    Content type: Research

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  13. Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...

    Authors: Marco M. E. Vogel, Kerstin A. Kessel, Kilian Schiller, Michal Devecka, Jürgen E. Gschwend, Wilko Weichert, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:198

    Content type: Research

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  14. The appropriate timing of radiotherapy (RT) for patients after radical prostatectomy (RP) with adverse pathological features (APFs) remains controversial. This systematic review was conducted to compare the ef...

    Authors: Ronggui Tao, Jindong Dai, Yunjin Bai, Jiyu Yang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Hao Zeng and Pengfei Shen

    Citation: Radiation Oncology 2019 14:197

    Content type: Review

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  15. To compare irradiation dose to the second and third portions of duodenum (Duo2 and Duo3) with a new refined and old delineation method of para-aortic region for patients with locally advanced cervical cancer (...

    Authors: Bo Yang, Xiaoliang Liu, Ke Hu, Jie Qiu, Fuquan Zhang, Xiaorong Hou, Junfang Yan, Qingyu Meng, Weiping Wang, Lang Yu and Yijun Wang

    Citation: Radiation Oncology 2019 14:196

    Content type: Research

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  16. The optimal treatment for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains inconclusive. Previous studies have shown that stereotactic body radiotherapy (SBRT) provides encouraging ...

    Authors: Baiqiang Dong, Jin Wang, Xuan Zhu, Yuanyuan Chen, Yujin Xu, Kainan Shao, Lei Zheng, Hangjie Ying, Ming Chen and Jianping Cao

    Citation: Radiation Oncology 2019 14:195

    Content type: Research

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  17. To determine the biological correlation between apparent diffusion coefficient (ADC) values and Sirtuin1 (SIRT1) levels of tumour tissues in patients with esophageal carcinoma (EC), and to ascertain the treatm...

    Authors: Ying Chen, Tieming Xie, Zhimin Ye, Fangzheng Wang, Dan Long, Mingxiang Jiang, Jun Fang, Qingren Lin, Kai Li, Zhun Wang and Zhenfu Fu

    Citation: Radiation Oncology 2019 14:192

    Content type: Research

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  18. Re-irradiation (re-RT) has the active effect of relieving clinical symptoms and prolonging the survival of patients with recurrent esophageal squamous cell carcinoma (ESCC). However, the optimal re-RT dose is ...

    Authors: Xiujuan Xu, Zhongming Wang, Shunian Jiang, Yuping Shang and Yan Wu

    Citation: Radiation Oncology 2019 14:191

    Content type: Research

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  19. We aimed to ascertain population-based practice patterns and survival outcomes of postoperative radiotherapy following breast conserving-surgery (BCS) in elderly women (aged ≥65 years) with early-stage pure mu...

    Authors: San-Gang Wu, Feng-Yan Li, Jun Wang, Chen-Lu Lian, Juan Zhou and Zhen-Yu He

    Citation: Radiation Oncology 2019 14:190

    Content type: Research

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  20. Thoracic and head and neck cancer radiation therapy (RT) can cause damage to nearby healthy organs such as the esophagus, causing acute radiation-induced esophageal damage (ARIED). A non-invasive method to det...

    Authors: Pouya Jelvehgaran, Jeffrey D. Steinberg, Artem Khmelinskii, Gerben Borst, Ji-Ying Song, Niels de Wit, Daniel M. de Bruin and Marcel van Herk

    Citation: Radiation Oncology 2019 14:188

    Content type: Research

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  21. Tumor motion may compromise the accuracy of liver stereotactic radiotherapy. In order to carry out a precise planning, estimating liver tumor motion during radiotherapy has received a lot of attention. Previou...

    Authors: Wu-zhou Li, Zhi-wen Liang, Yi Cao, Ting-ting Cao, Hong Quan, Zhi-yong Yang, Qin Li and Zhi-tao Dai

    Citation: Radiation Oncology 2019 14:185

    Content type: Research

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  22. Stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) are well established local treatment approaches in several cancer settings. Although SBRT is still under investigation for spinal metas...

    Authors: Niccolò Giaj-Levra, Maximilian Niyazi, Vanessa Figlia, Giuseppe Napoli, Rosario Mazzola, Luca Nicosia, Stefanie Corradini, Ruggero Ruggieri, Giuseppe Minniti and Filippo Alongi

    Citation: Radiation Oncology 2019 14:184

    Content type: Research

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  23. Patients with N3 stage nasopharyngeal carcinoma (NPC) are at high risk for treatment failure. This study aims to assess the efficacy of maintenance chemotherapy (MC) using S-1 (MC-S1), a novel oral fluoropyrim...

    Authors: Jingfeng Zong, Hanchuan Xu, Bijuan Chen, Qiaojuan Guo, Yun Xu, Chuanben Chen, Youliang Weng, Wei Zheng, Jianji Pan and Shaojun Lin

    Citation: Radiation Oncology 2019 14:182

    Content type: Research

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  24. We aimed to identify the risk factors and provide a nomogram for the prediction of radiotherapy-related esophageal fistula in patients with esophageal cancer (EC) using a case-control study.

    Authors: Yiyue Xu, Linlin Wang, Bo He, Wanlong Li, Qiang Wen, Shijiang Wang, Xindong Sun, Xue Meng and Jinming Yu

    Citation: Radiation Oncology 2019 14:181

    Content type: Research

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  25. This study aimed to compare the clinical outcomes of stereotactic ablative radiotherapy (SABR) and conventionally fractionated radiotherapy (CFRT) in hepatocellular carcinoma (HCC) patients with portal vein in...

    Authors: Jen-Fu Yang, Cheng-Hsiang Lo, Meei-Shyuan Lee, Chun-Shu Lin, Yang-Hong Dai, Po-Chien Shen, Hsing-Lung Chao and Wen-Yen Huang

    Citation: Radiation Oncology 2019 14:180

    Content type: Research

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  26. To assess late toxicity, quality of life and oncological outcome after consolidative whole abdominal radiotherapy (WART) following cytoreductive surgery and carboplatin/paclitaxel chemotherapy in high risk pat...

    Authors: Nathalie Arians, Meinhard Kieser, Laura Benner, Nathalie Rochet, Lars Schröder, Sonja Katayama, Klaus Herfarth, Kai Schubert, Andreas Schneeweiss, Christof Sohn, Katja Lindel and Jürgen Debus

    Citation: Radiation Oncology 2019 14:179

    Content type: Research

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  27. Radiation Therapy Oncology Group (RTOG) 94–05 has demonstrated that higher dose radiation didn’t improve outcome of patients with esophageal cancer (EC). However, several retrospective studies showed that a hi...

    Authors: He-San Luo, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:178

    Content type: Review

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  28. There is no general consensus on the optimal treatment for prostate cancer (PC) patients with intrapelvic nodal oligorecurrences after radical prostatectomy. Besides androgen deprivation therapy (ADT) as stand...

    Authors: Cedric Panje, Thomas Zilli, Alan Dal Pra, Winfried Arnold, Kathrin Brouwer, Helena I. Garcia Schüler, Silvia Gomez, Fernanda Herrera, Kaouthar Khanfir, Alexandros Papachristofilou, Gianfranco Pesce, Christiane Reuter, Hansjörg Vees, Daniel Zwahlen and Paul Martin Putora

    Citation: Radiation Oncology 2019 14:177

    Content type: Research

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  29. To assess the comparative efficacy and safety of elective nodal irradiation (ENI) and involved-field irradiation (IFI) in patients with esophageal cancer (EC) receiving neoadjuvant chemoradiotherapy plus surge...

    Authors: Tingting Liu, Silu Ding, Jun Dang, Hui Wang, Jun Chen and Guang Li

    Citation: Radiation Oncology 2019 14:176

    Content type: Research

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  30. We evaluated the long-term outcomes and late toxicity of conventional fractionated (CF) and hypofractionated (HF) postmastectomy radiotherapy (PMRT) in terms of locoregional recurrence-free survival (LRRFS), d...

    Authors: Imjai Chitapanarux, Pitchayaponne Klunklin, Attapol Pinitpatcharalert, Patumrat Sripan, Ekkasit Tharavichitkul, Wannapha Nobnop, Wimrak Onchan, Somvilai Chakrabandhu, Bongkot Jia-Mahasap, Juntima Euathrongchit, Yutthaphan Wannasopha and Tanop Srisuwan

    Citation: Radiation Oncology 2019 14:175

    Content type: Research

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  31. This study aimed to evaluate the clinical and dosimetric factors predictive of acute anal toxicity (AAT) after radiotherapy in prostate cancer (PCa) patients with or without hemorrhoids.

    Authors: Xingsi Peng, Sha Zhou, Shiliang Liu, Jibin Li, Sijuan Huang, Xiaobo Jiang, Maosheng Lin, Shaomin Huang, Chengguang Lin, Chaonan Qian, Mengzhong Liu and Liru He

    Citation: Radiation Oncology 2019 14:174

    Content type: Research

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  32. Ultrasound (US) imaging has been proved as an excellent diagnostic tool in gynecology and, due to its wide availability and limited cost, is under intense investigation as base for dose adaptation in cervical ...

    Authors: Mario Federico, Carmen Rosa Hernandez-Socorro, Ivone Ribeiro, Jesus Gonzalez Martin, Maria Dolores Rey-Baltar Oramas, Marta Lloret Saez-Bravo and Pedro Carlos Lara Jimenez

    Citation: Radiation Oncology 2019 14:173

    Content type: Research

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  33. Prophylactic cranial irradiation (PCI) is indicated for limited-stage small cell lung cancer (LS-SCLC) with good response to chemoradiotherapy (CRT). However, brain metastasis (BM) developed in LS-SCLC before ...

    Authors: Xiao Chu, Shuyan Li, Bingqing Xia, Li Chu, Xi Yang, Jianjiao Ni, Liqing Zou, Yida Li, Congying Xie, Jie Lin and Zhengfei Zhu

    Citation: Radiation Oncology 2019 14:171

    Content type: Research

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  34. Pathogenesis of brain metastases/meningeal cancer and the emotional and neurological outcomes are not yet well understood. The hypothesis of our study is that patients with leptomeningeal cancer show volumetri...

    Authors: Michael Mayinger, Antonia Reibelt, Kai Joachim Borm, Johannes Ettl, Jan J. Wilkens, Stephanie Elisabeth Combs, Markus Oechsner and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:170

    Content type: Research

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  35. Leptomeningeal metastasis (LM) is a devastating and terminal complication of advanced non-small-cell lung cancer (NSCLC), especially in patients harboring epidermal growth factor receptor (EGFR) mutations. The...

    Authors: Weiwei Yan, Yang Liu, Ji Li, Anqin Han, Li Kong, Jinming Yu and Hui Zhu

    Citation: Radiation Oncology 2019 14:168

    Content type: Research

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  36. The purpose of this study was to assess the feasibility, efficacy and toxicity of fiducial marker implantation and tracking in CyberKnife® stereotactic radiation therapy (SBRT) applied to extracranial locations.

    Authors: Nathaniel Scher, Marc Bollet, Gauthier Bouilhol, Remi Tannouri, Imane Khemiri, Aurelie Vouillaume, Noura Sellami, Rie Von Eyben, Jean-Michel Vannetzel, Ilan Darmon, Luc Rotenberg, Hanah Lamallem, Olivier Bauduceau, Denis Foster and Alain Toledano

    Citation: Radiation Oncology 2019 14:167

    Content type: Research

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  37. Sarcopenia, the critical depletion of skeletal muscle mass, is an independent prognostic factor in several tumor entities for treatment-related toxicity and survival. In esophageal cancer, there have been conf...

    Authors: Cédric M. Panje, Laura Höng, Stefanie Hayoz, Vickie E. Baracos, Evelyn Herrmann, Helena Garcia Schüler, Urs R. Meier, Guido Henke, Sabina Schacher, Hanne Hawle, Marie-Aline Gérard, Thomas Ruhstaller and Ludwig Plasswilm

    Citation: Radiation Oncology 2019 14:166

    Content type: Research

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  38. In prostate cancer patients, imaging of bone metastases is enhanced through the use of sodium fluoride positron emission tomography (18F-NaF PET/CT). This imaging technique shows areas of enhanced osteoblastic ac...

    Authors: Nicholas Hardcastle, Michael S. Hofman, Ching-Yu Lee, Jason Callahan, Lisa Selbie, Farshad Foroudi, Mark Shaw, Sarat Chander, Andrew Lim, Brent Chesson, Declan G. Murphy, Tomas Kron and Shankar Siva

    Citation: Radiation Oncology 2019 14:164

    Content type: Research

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  39. To determine the feasibility of PET/CT-based image-guided moderate hypofractionated thoracic irradiation (Hypo-IGRT) in locally advanced node-positive non-small cell lung cancer patients with highly compromise...

    Authors: Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Nina-Sophie Schmidt-Hegemann, Lukas Käsmann, Cherylina Wijaya, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2019 14:163

    Content type: Research

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  40. The prognosis of N categories for patients with non-surgical esophageal carcinoma based on the number of metastatic lymph nodes is controversial. The present study analyzes prognostic implications of the numbe...

    Authors: Zongxing Zhao, Yanan Zhang, Peiliang Wang, Xin Wang and Minghuan Li

    Citation: Radiation Oncology 2019 14:161

    Content type: Research

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  41. Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection. In case of anaplastic meningiomas (WHO...

    Authors: Saman Moritz Hemmati, Pirus Ghadjar, Arne Grün, Harun Badakhshi, Sebastian Zschaeck, Carolin Senger, Güliz Acker, Martin Misch, Volker Budach and David Kaul

    Citation: Radiation Oncology 2019 14:160

    Content type: Research

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  42. This study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence (IBTR) based on our data on re-operative sentinel lymph node biopsy (re...

    Authors: Ayaka Sato, Takehiko Sakai, Takuji Iwase, Fumiko Kano, Kiyomi Kimura, Akiko Ogiya, Mitsuru Koizumi, Masahiko Tanabe, Rie Horii, Futoshi Akiyama, Takayuki Ueno and Shinji Ohno

    Citation: Radiation Oncology 2019 14:159

    Content type: Research

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  43. To report results from our phase I dose-escalation study of stereotactic body radiotherapy (SBRT) using 4 fractions for patients with localized prostate cancer.

    Authors: Takuro Kainuma, Shogo Kawakami, Hideyasu Tsumura, Takefumi Satoh, Ken-ichi Tabata, Masatsugu Iwamura, Kazushige Hayakawa and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:158

    Content type: Research

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  44. Radiotherapy is frequently used in the therapy of lymphoma. Since lymphoma, for example Hodgkin’s disease, frequently affect rather young patients, the induction of secondary cancer or other long-term adverse ...

    Authors: S. Lautenschlaeger, G. Iancu, V. Flatten, K. Baumann, M. Thiemer, C. Dumke, K. Zink, H. Hauswald, D. Vordermark, C. Mauz-Körholz, R. Engenhart-Cabillic and F. Eberle

    Citation: Radiation Oncology 2019 14:157

    Content type: Research

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  45. Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-...

    Authors: Daniel Karpf, Mazen Sakka, Martin Metzger and Gerhard G. Grabenbauer

    Citation: Radiation Oncology 2019 14:156

    Content type: Research

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  46. Transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are cytokines involved in fibrotic processes causing radiotherapy (RT)-induced cardiovascular changes. We aimed to investiga...

    Authors: Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: Radiation Oncology 2019 14:155

    Content type: Research

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  47. The heart and lungs are routinely exposed to incidental irradiation during adjuvant radiotherapy (RT) of breast cancer. We analyzed the impact of patient and treatment characteristics on heart and lung dose in...

    Authors: Tobias Finazzi, Van-Trinh Nguyen, Frank Zimmermann and Alexandros Papachristofilou

    Citation: Radiation Oncology 2019 14:153

    Content type: Research

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