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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    Prophylactic cranial irradiation (PCI) is indicated for limited-stage small cell lung cancer (LS-SCLC) with good response to chemoradiotherapy (CRT). However, brain metastasis (BM) developed in LS-SCLC before ...

    Authors: Xiao Chu, Shuyan Li, Bingqing Xia, Li Chu, Xi Yang, Jianjiao Ni, Liqing Zou, Yida Li, Congying Xie, Jie Lin and Zhengfei Zhu

    Citation: Radiation Oncology 2019 14:171

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  2. Content type: Research

    Pathogenesis of brain metastases/meningeal cancer and the emotional and neurological outcomes are not yet well understood. The hypothesis of our study is that patients with leptomeningeal cancer show volumetri...

    Authors: Michael Mayinger, Antonia Reibelt, Kai Joachim Borm, Johannes Ettl, Jan J. Wilkens, Stephanie Elisabeth Combs, Markus Oechsner and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:170

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  3. Content type: Research

    Leptomeningeal metastasis (LM) is a devastating and terminal complication of advanced non-small-cell lung cancer (NSCLC), especially in patients harboring epidermal growth factor receptor (EGFR) mutations. The...

    Authors: Weiwei Yan, Yang Liu, Ji Li, Anqin Han, Li Kong, Jinming Yu and Hui Zhu

    Citation: Radiation Oncology 2019 14:168

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  4. Content type: Research

    The purpose of this study was to assess the feasibility, efficacy and toxicity of fiducial marker implantation and tracking in CyberKnife® stereotactic radiation therapy (SBRT) applied to extracranial locations.

    Authors: Nathaniel Scher, Marc Bollet, Gauthier Bouilhol, Remi Tannouri, Imane Khemiri, Aurelie Vouillaume, Noura Sellami, Rie Von Eyben, Jean-Michel Vannetzel, Ilan Darmon, Luc Rotenberg, Hanah Lamallem, Olivier Bauduceau, Denis Foster and Alain Toledano

    Citation: Radiation Oncology 2019 14:167

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  5. Content type: Research

    Sarcopenia, the critical depletion of skeletal muscle mass, is an independent prognostic factor in several tumor entities for treatment-related toxicity and survival. In esophageal cancer, there have been conf...

    Authors: Cédric M. Panje, Laura Höng, Stefanie Hayoz, Vickie E. Baracos, Evelyn Herrmann, Helena Garcia Schüler, Urs R. Meier, Guido Henke, Sabina Schacher, Hanne Hawle, Marie-Aline Gérard, Thomas Ruhstaller and Ludwig Plasswilm

    Citation: Radiation Oncology 2019 14:166

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  6. Content type: Research

    In prostate cancer patients, imaging of bone metastases is enhanced through the use of sodium fluoride positron emission tomography (18F-NaF PET/CT). This imaging technique shows areas of enhanced osteoblastic ac...

    Authors: Nicholas Hardcastle, Michael S. Hofman, Ching-Yu Lee, Jason Callahan, Lisa Selbie, Farshad Foroudi, Mark Shaw, Sarat Chander, Andrew Lim, Brent Chesson, Declan G. Murphy, Tomas Kron and Shankar Siva

    Citation: Radiation Oncology 2019 14:164

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  7. Content type: Research

    To determine the feasibility of PET/CT-based image-guided moderate hypofractionated thoracic irradiation (Hypo-IGRT) in locally advanced node-positive non-small cell lung cancer patients with highly compromise...

    Authors: Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Nina-Sophie Schmidt-Hegemann, Lukas Käsmann, Cherylina Wijaya, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2019 14:163

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  8. Content type: Research

    The prognosis of N categories for patients with non-surgical esophageal carcinoma based on the number of metastatic lymph nodes is controversial. The present study analyzes prognostic implications of the numbe...

    Authors: Zongxing Zhao, Yanan Zhang, Peiliang Wang, Xin Wang and Minghuan Li

    Citation: Radiation Oncology 2019 14:161

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  9. Content type: Research

    Meningiomas are the most common primary tumors of the central nervous system. In patients with WHO grade I meningiomas no adjuvant therapy is recommended after resection. In case of anaplastic meningiomas (WHO...

    Authors: Saman Moritz Hemmati, Pirus Ghadjar, Arne Grün, Harun Badakhshi, Sebastian Zschaeck, Carolin Senger, Güliz Acker, Martin Misch, Volker Budach and David Kaul

    Citation: Radiation Oncology 2019 14:160

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  10. Content type: Research

    This study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence (IBTR) based on our data on re-operative sentinel lymph node biopsy (re...

    Authors: Ayaka Sato, Takehiko Sakai, Takuji Iwase, Fumiko Kano, Kiyomi Kimura, Akiko Ogiya, Mitsuru Koizumi, Masahiko Tanabe, Rie Horii, Futoshi Akiyama, Takayuki Ueno and Shinji Ohno

    Citation: Radiation Oncology 2019 14:159

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  11. Content type: Research

    To report results from our phase I dose-escalation study of stereotactic body radiotherapy (SBRT) using 4 fractions for patients with localized prostate cancer.

    Authors: Takuro Kainuma, Shogo Kawakami, Hideyasu Tsumura, Takefumi Satoh, Ken-ichi Tabata, Masatsugu Iwamura, Kazushige Hayakawa and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:158

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  12. Content type: Research

    Radiotherapy is frequently used in the therapy of lymphoma. Since lymphoma, for example Hodgkin’s disease, frequently affect rather young patients, the induction of secondary cancer or other long-term adverse ...

    Authors: S. Lautenschlaeger, G. Iancu, V. Flatten, K. Baumann, M. Thiemer, C. Dumke, K. Zink, H. Hauswald, D. Vordermark, C. Mauz-Körholz, R. Engenhart-Cabillic and F. Eberle

    Citation: Radiation Oncology 2019 14:157

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  13. Content type: Research

    Adjuvant radiotherapy is the standard treatment after breast-conserving surgery. According to meta-analyses, adjuvant 3d-conventional irradiation reduces the risk of local recurrence and thereby improves long-...

    Authors: Daniel Karpf, Mazen Sakka, Martin Metzger and Gerhard G. Grabenbauer

    Citation: Radiation Oncology 2019 14:156

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  14. Content type: Research

    Transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are cytokines involved in fibrotic processes causing radiotherapy (RT)-induced cardiovascular changes. We aimed to investiga...

    Authors: Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: Radiation Oncology 2019 14:155

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  15. Content type: Research

    The heart and lungs are routinely exposed to incidental irradiation during adjuvant radiotherapy (RT) of breast cancer. We analyzed the impact of patient and treatment characteristics on heart and lung dose in...

    Authors: Tobias Finazzi, Van-Trinh Nguyen, Frank Zimmermann and Alexandros Papachristofilou

    Citation: Radiation Oncology 2019 14:153

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  16. Content type: Research

    Nutritional status and haematological parameters are related to the prognosis of patients treated with radiotherapy, but the correlation between adaptive radiotherapy (ART) and haematological indicators has ne...

    Authors: Ning Han, Xintong Lyu, Guang Li and Qiao Qiao

    Citation: Radiation Oncology 2019 14:151

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  17. Content type: Research

    The present prospective study evaluated the safety and efficacy of the rectum following KUSHEN Ningjiaos in cervical cancer. We compared rectal wall changes during brachytherapy with or without KUSHEN Ningjiaos i...

    Authors: Xiaojuan Li, Cheng Xiao, Yilin Kong, Weiwei Guo, Wenting Zhan, Gong Li, Xuetao Wang, Bailin Zhang and Lei Gao

    Citation: Radiation Oncology 2019 14:149

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  18. Content type: Methodology

    To evaluate and establish a digital workflow for the custom designing and 3D printing of mouth opening tongue-depressing (MOTD) stents for patients receiving radiotherapy for head and neck cancer.

    Authors: Mohamed Zaid, Nimit Bajaj, Hannah Burrows, Ryan Mathew, Annie Dai, Christopher T. Wilke, Stephen Palasi, Ryan Hergenrother, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David I. Rosenthal…

    Citation: Radiation Oncology 2019 14:148

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  19. Content type: Research

    There is continued debate regarding the optimal combinations of radiation therapy and chemotherapy in the preoperative treatment of locally advanced rectal adenocarcinomas. We report our single-institution exp...

    Authors: Angela Y. Jia, Amol Narang, Bashar Safar, Atif Zaheer, Adrian Murphy, Nilofer S. Azad, Susan Gearhart, Sandy Fang, Jonathan Efron, Tam Warczynski, Amy Hacker-Prietz and Jeffrey Meyer

    Citation: Radiation Oncology 2019 14:147

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  20. Content type: Review

    At present, the standard treatment approach for locally advanced cervical cancer is concurrent chemoradiotherapy (CCRT). An elevated pretreatment squamous cell carcinoma antigen (SCC Ag) level is associated wi...

    Authors: Jingxuan Fu, Weiping Wang, Yidan Wang, Chengeng Liu and Peichang Wang

    Citation: Radiation Oncology 2019 14:146

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  21. Content type: Research

    Comparing radiation treatment plans by using the same safety margins and dose objectives for all techniques, to ascertain the optimal radiation technique for the stereotactic body radiotherapy (SBRT) of low-ri...

    Authors: Sergiu Scobioala, Christopher Kittel, Khaled Elsayad, Kai Kroeger, Michael Oertel, Laith Samhouri, Uwe Haverkamp and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:143

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  22. Content type: Research

    To investigate the prognostic significance of positron emission tomography (PET) parameters from F-18 fluorodeoxyglucose (FDG) PET scans performed pre- and post- chemo-radiotherapy (CRT) for squamous cell carc...

    Authors: Michael Peter Jones, George Hruby, Ur Metser, Swetha Sridharan, Anne Capp, Mahesh Kumar, Sarah Gallagher, Natalie Rutherford, Carl Holder, Christopher Oldmeadow and Jarad Martin

    Citation: Radiation Oncology 2019 14:140

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  23. Content type: Research

    The aim of this study was to explore the impact of including or excluding the ischiorectal fossa (IRF) within the clinical target volume during neoadjuvant chemoradiotherapy (NCRT) using intensity modulated ra...

    Authors: Maxiaowei Song, Jianhao Geng, Lin Wang, Yongheng Li, Xianggao Zhu, Xiaofan Li, Lan Mi, Aiwen Wu, Yifan Peng, Yunfeng Yao, Yangzi Zhang, Hongzhi Wang, Chen Shi, Yong Cai and Weihu Wang

    Citation: Radiation Oncology 2019 14:138

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  24. Content type: Research

    We compared clinical outcomes of carbon ion radiotherapy and transarterial chemoembolization in the treatment of hepatocellular carcinoma.

    Authors: Shintaro Shiba, Kei Shibuya, Hiroyuki Katoh, Takuya Kaminuma, Masaya Miyazaki, Satoru Kakizaki, Ken Shirabe, Tatsuya Ohno and Takashi Nakano

    Citation: Radiation Oncology 2019 14:137

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  25. Content type: Research

    Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for the treatment of prostate cancer. However, few have reported outcomes for pros...

    Authors: Mark E. Hwang, Mark Mayeda, Maria Liz, Brenda Goode-Marshall, Lissette Gonzalez, Carl D. Elliston, Catherine S. Spina, Oscar A. Padilla, Sven Wenske and Israel Deutsch

    Citation: Radiation Oncology 2019 14:136

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  26. Content type: Research

    Along with breast-conserving surgery (BCS), adjuvant radiotherapy (RT) of patients with early breast cancer plays a crucial role in the oncologic treatment concept. Conventionally, irradiation is carried out w...

    Authors: Michael Mayinger, Kai Joachim Borm, Constantin Dreher, Hendrik Dapper, Marciana-Nona Duma, Markus Oechsner, Severin Kampfer, Stephanie Elisabeth Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:135

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  27. Content type: Research

    Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Authors: Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Felix Behling, Marco Skardelly, Benjamin Bender, Daniel Zips and Franziska Eckert

    Citation: Radiation Oncology 2019 14:132

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  28. Content type: Research

    Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

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  29. Content type: Case report

    The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

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  30. Content type: Research

    Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to...

    Authors: Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling and Andrew Ju

    Citation: Radiation Oncology 2019 14:124

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  31. Content type: Study protocol

    For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortene...

    Authors: Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus and Klaus Herfarth

    Citation: Radiation Oncology 2019 14:122

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  32. Content type: Research

    The boost irradiation to the tumor bed following whole-breast irradiation (WBI) reduced the risk of ipsilateral breast tumor recurrence (IBTR). However, in Japan, almost all patients with a margin ≤5 mm receiv...

    Authors: Yuka Ono, Michio Yoshimura, Kimiko Hirata, Chikako Yamauchi, Masakazu Toi, Eiji Suzuki, Masahiro Takada, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:121

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  33. Content type: Research

    Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline resectable, and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to the optim...

    Authors: Qiancheng Hu, Dan Wang, Ye Chen, Xiaofen Li, Peng Cao and Dan Cao

    Citation: Radiation Oncology 2019 14:120

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  34. Content type: Research

    Primary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting with unresectable tumors, severe comorbidities, or incomplete surgical resection,...

    Authors: Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl

    Citation: Radiation Oncology 2019 14:117

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  35. Content type: Research

    Systemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), er...

    Authors: Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung

    Citation: Radiation Oncology 2019 14:116

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  36. Content type: Research

    To investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally recurrent breast cancer (RBC) after mastectomy as primary treatment.

    Authors: Gang Cai, Lu Cao, Youlia M. Kirova, Yan Feng and Jia-Yi Chen

    Citation: Radiation Oncology 2019 14:115

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  37. Content type: Review

    Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman

    Citation: Radiation Oncology 2019 14:114

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  38. Content type: Research

    To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...

    Authors: Shichao Wang, Feng Wen, Pengfei Zhang, Xin Wang and Qiu Li

    Citation: Radiation Oncology 2019 14:113

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  39. Content type: Research

    Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...

    Authors: Elisabetta Parisi, Giovenzio Genestreti, Anna Sarnelli, Giulia Ghigi, Donatella Arpa, Marco Angelo Burgio, Giampaolo Gavelli, Alice Rossi, Emanuela Scarpi, Manuela Monti, Anna Tesei, Rolando Polico and Antonino Romeo

    Citation: Radiation Oncology 2019 14:112

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  40. Content type: Research

    Incurable inflammatory breast cancer (IBC) patients occasionally suffer from general symptoms such as breast pain, bleeding, ulceration, and discharge, and thus require palliative radiotherapy (RT). Hypofracti...

    Authors: Hoon Sik Choi, Hong Seok Jang, Ki Mun Kang and Byung-ock Choi

    Citation: Radiation Oncology 2019 14:110

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  41. Content type: Research

    The aim of this study was to compare dose-volume histogram (DVH) with dose-mass histogram (DMH) parameters for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (F...

    Authors: Markus Oechsner, Mathias Düsberg, Kai Joachim Borm, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:109

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  42. Content type: Research

    Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

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  43. Content type: Research

    Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

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  44. Content type: Research

    Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: br...

    Authors: Jan Haussmann, Wilfried Budach, Balint Tamaskovics, Edwin Bölke, Stefanie Corradini, Freddy-Joel Djiepmo-Njanang, Kai Kammers and Christiane Matuschek

    Citation: Radiation Oncology 2019 14:102

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  45. Content type: Research

    The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

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  46. Content type: Research

    The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cerv...

    Authors: Lina Yin, Saiquan Lu, Jun Zhu, Weiling Zhang and Guihao Ke

    Citation: Radiation Oncology 2019 14:100

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