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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

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  2. Content type: Case report

    The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

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  3. Content type: Research

    Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to...

    Authors: Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling and Andrew Ju

    Citation: Radiation Oncology 2019 14:124

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  4. Content type: Study protocol

    For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortene...

    Authors: Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus and Klaus Herfarth

    Citation: Radiation Oncology 2019 14:122

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  5. Content type: Research

    The boost irradiation to the tumor bed following whole-breast irradiation (WBI) reduced the risk of ipsilateral breast tumor recurrence (IBTR). However, in Japan, almost all patients with a margin ≤5 mm receiv...

    Authors: Yuka Ono, Michio Yoshimura, Kimiko Hirata, Chikako Yamauchi, Masakazu Toi, Eiji Suzuki, Masahiro Takada, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:121

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  6. Content type: Research

    Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline resectable, and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to the optim...

    Authors: Qiancheng Hu, Dan Wang, Ye Chen, Xiaofen Li, Peng Cao and Dan Cao

    Citation: Radiation Oncology 2019 14:120

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  7. Content type: Research

    Primary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting with unresectable tumors, severe comorbidities, or incomplete surgical resection,...

    Authors: Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl

    Citation: Radiation Oncology 2019 14:117

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  8. Content type: Research

    Systemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), er...

    Authors: Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung

    Citation: Radiation Oncology 2019 14:116

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  9. Content type: Research

    To investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally recurrent breast cancer (RBC) after mastectomy as primary treatment.

    Authors: Gang Cai, Lu Cao, Youlia M. Kirova, Yan Feng and Jia-Yi Chen

    Citation: Radiation Oncology 2019 14:115

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  10. Content type: Review

    Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman

    Citation: Radiation Oncology 2019 14:114

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  11. Content type: Research

    To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...

    Authors: Shichao Wang, Feng Wen, Pengfei Zhang, Xin Wang and Qiu Li

    Citation: Radiation Oncology 2019 14:113

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  12. Content type: Research

    Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...

    Authors: Elisabetta Parisi, Giovenzio Genestreti, Anna Sarnelli, Giulia Ghigi, Donatella Arpa, Marco Angelo Burgio, Giampaolo Gavelli, Alice Rossi, Emanuela Scarpi, Manuela Monti, Anna Tesei, Rolando Polico and Antonino Romeo

    Citation: Radiation Oncology 2019 14:112

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  13. Content type: Research

    Incurable inflammatory breast cancer (IBC) patients occasionally suffer from general symptoms such as breast pain, bleeding, ulceration, and discharge, and thus require palliative radiotherapy (RT). Hypofracti...

    Authors: Hoon Sik Choi, Hong Seok Jang, Ki Mun Kang and Byung-ock Choi

    Citation: Radiation Oncology 2019 14:110

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  14. Content type: Research

    The aim of this study was to compare dose-volume histogram (DVH) with dose-mass histogram (DMH) parameters for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (F...

    Authors: Markus Oechsner, Mathias Düsberg, Kai Joachim Borm, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:109

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  15. Content type: Research

    Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

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  16. Content type: Research

    Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

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  17. Content type: Research

    Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: br...

    Authors: Jan Haussmann, Wilfried Budach, Balint Tamaskovics, Edwin Bölke, Stefanie Corradini, Freddy-Joel Djiepmo-Njanang, Kai Kammers and Christiane Matuschek

    Citation: Radiation Oncology 2019 14:102

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  18. Content type: Research

    The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

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  19. Content type: Research

    The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cerv...

    Authors: Lina Yin, Saiquan Lu, Jun Zhu, Weiling Zhang and Guihao Ke

    Citation: Radiation Oncology 2019 14:100

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  20. Content type: Research

    Determining the appropriate gross tumor volume is important for irradiation planning in addition to palliative radiation for bone metastases. While irradiation planning is commonly performed using simulation c...

    Authors: Yuki Wada, Akira Anbai, Satoshi Kumagai, Eriko Okuyama, Kento Hatakeyama, Noriko Takagi and Manabu Hashimoto

    Citation: Radiation Oncology 2019 14:98

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  21. Content type: Research

    The aim of this study was to assess the correlations between the levels of blood glucose (BG) and the dose of radiation therapy (RT) to the central gustatory system (GS) in glioblastoma multiforme (GBM) patients.

    Authors: Marciana N. Duma, Nadja I. Oszfolk, Tobias Boeckh-Behrens, Markus Oechsner, Claus Zimmer, Bernhard Meyer, Paul T. Pfluger and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:97

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  22. Content type: Research

    It is uncertain if whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) improves biochemical progression-free survival (bPFS) after prostatectomy for locally advanced t...

    Authors: Carola Link, Patrick Honeck, Akiko Makabe, Frank Anton Giordano, Christian Bolenz, Joerg Schaefer, Markus Bohrer, Frank Lohr, Frederik Wenz and Daniel Buergy

    Citation: Radiation Oncology 2019 14:96

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  23. Content type: Research

    To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual...

    Authors: Yafang Zhang, Ping Li, Qi Yu, Shuang Wu, Xue Chen, Qing Zhang and Shen Fu

    Citation: Radiation Oncology 2019 14:94

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  24. Content type: Review

    Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrou...

    Authors: S. Corradini, F. Alongi, N. Andratschke, C. Belka, L. Boldrini, F. Cellini, J. Debus, M. Guckenberger, J. Hörner-Rieber, F. J. Lagerwaard, R. Mazzola, M. A. Palacios, M. E. P. Philippens, C. P. J. Raaijmakers, C. H. J. Terhaard, V. Valentini…

    Citation: Radiation Oncology 2019 14:92

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  25. Content type: Research

    Although circular collimator arcs (CCA) and dynamic conformal arcs (DCA) are commonly used linear accelerator-based treatment planning techniques for intracranial stereotactic radiosurgery (SRS) of a small sin...

    Authors: Yongsook C. Lee and Yongbok Kim

    Citation: Radiation Oncology 2019 14:91

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  26. Content type: Research

    To evaluate the practicality of NS-21 cream with regard to its skin-related toxicity in patients with head and neck cancer (HNC) who are undergoing concurrent chemoradiation therapy (CCRT) or radiotherapy (RT).

    Authors: Hsiu-Ling Chou, Pei-Wei Shueng, Li-Jen Liao, Chen-Xiong Hsu, Deng-Yu Kuo, Wu-Chia Lo, Pei-Yu Hou, Li-Ying Wang, San-Fang Chou and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2019 14:90

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  27. Content type: Research

    This study set out to evaluate the effect of dose rate on normal tissues (the lung, in particular) and the variation in the treatment efficiency as determined by the monitor unit (MU) and energy applied in Lin...

    Authors: Jaeman Son, Noorie Choi, Jung-in Kim, Jong Min Park, Hong-Gyun Wu, Hyun-Cheol Kang and Chang Heon Choi

    Citation: Radiation Oncology 2019 14:87

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  28. Content type: Research

    To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) and its associations with patient outcomes in non-small cell lun...

    Authors: Qianqian Zhao, Gang Chen, Luxi Ye, Shiming Shi, Shisuo Du, Zhaochong Zeng and Jian He

    Citation: Radiation Oncology 2019 14:86

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  29. Content type: Research

    The prognostic significance of radiation dose to the lung or heart is unknown in esophageal cancer patients receiving neoadjuvant chemoradiotherapy followed by surgery (trimodal therapy). This study aimed to d...

    Authors: Jhen-Bin Lin, Li-Chung Hung, Ching-Yuan Cheng, Yu-An Chien, Chou-Hsien Lee, Chia-Chun Huang, Tsai-Wei Chou, Ming-Huei Ko, Yuan-Chun Lai, Mu-Tai Liu, Tung-Hao Chang, Jie Lee and Yu-Jen Chen

    Citation: Radiation Oncology 2019 14:85

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  30. Content type: Review

    Radiation or radiochemotherapy is a common adjuvant therapy for gastric cancer. Intensity-modulated radiation therapy (IMRT) has been demonstrated to provide better dose conformity, allowing dose escalation an...

    Authors: Fang Ren, Shaodan Li, Yin Zhang, Zhifei Zhao, Haiming Wang, Yixin Cui and Maoyun Wang

    Citation: Radiation Oncology 2019 14:84

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  31. Content type: Research

    Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however rando...

    Authors: Florence Legouté, René-Jean Bensadoun, Valérie Seegers, Yoann Pointreau, Delphine Caron, Philippe Lang, Alain Prévost, Laurent Martin, Ulrike Schick, Benjamin Morvant, Olivier Capitain, Gilles Calais and Eric Jadaud

    Citation: Radiation Oncology 2019 14:83

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  32. Content type: Research

    The clinical efficacy of definitive pelvic radiotherapy for primary tumors in patients with newly diagnosed organ metastatic cervical cancer is unclear. Therefore, we conducted a retrospective study to evaluat...

    Authors: Zhuomin Yin, Hanmei Lou, Huarong Tang, Juan Ni, Qiong Zhou and Ming Chen

    Citation: Radiation Oncology 2019 14:82

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  33. Content type: Research

    The impact of sex on prognosis of patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. The present study aimed to determine the impact of sex on the prog...

    Authors: He-San Luo, Hong-Yao Xu, Ze-Sen Du, Xu-Yuan Li, Sheng-Xi Wu, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:74

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  34. Content type: Research

    To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol.

    Authors: Sotirios Katsigiannis, Boris Krischek, Stefanie Barleanu, Stefan Grau, Norbert Galldiks, Marco Timmer, Christoph Kabbasch, Roland Goldbrunner and Pantelis Stavrinou

    Citation: Radiation Oncology 2019 14:73

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  35. Content type: Research

    An objective way to qualify the effect of radiotherapy (RT) on lung tissue is the analysis of CT scans after RT. In this analysis we focused on the changes in Hounsfield units (ΔHU) and the correlation with th...

    Authors: Christina Schröder, Rita Engenhart-Cabillic, Sven Kirschner, Eyck Blank and André Buchali

    Citation: Radiation Oncology 2019 14:72

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  36. Content type: Review

    Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer.

    Authors: Luca Boldrini, Davide Cusumano, Francesco Cellini, Luigi Azario, Gian Carlo Mattiucci and Vincenzo Valentini

    Citation: Radiation Oncology 2019 14:71

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  37. Content type: Research

    Intraductal carcinoma of the prostate (IDC-P) is an independent biomarker of recurrence and survival with particular treatment response, yet no study has tested its response to radiotherapy. The aim of our pro...

    Authors: Vincent Q. Trinh, Nazim Benzerdjeb, Ségolène Chagnon-Monarque, Nicolas Dionne, Guila Delouya, André Kougioumoutzakis, Jennifer Sirois, Roula Albadine, Mathieu Latour, Anne-Marie Mes-Masson, Hélène Hovington, Alain Bergeron, Kevin C. Zorn, Yves Fradet, Fred Saad, Daniel Taussky…

    Citation: Radiation Oncology 2019 14:60

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  38. Content type: Research

    The aim was to evaluate the outcome, especially locoregional control of patients with locally advanced salivary gland carcinoma (SGC) with perineural spread (Pn1) and/or positive resection margins (R1/2) after...

    Authors: Marlen Haderlein, Claudia Scherl, Sabine Semrau, Sebastian Lettmaier, Markus Hecht, Florian Putz, Heinrich Iro, Abbas Agaimy and Rainer Fietkau

    Citation: Radiation Oncology 2019 14:68

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  39. Content type: Research

    Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Th...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Marcus Feith, Helmut Friess, Wilko Weichert, Moritz Jesinghaus, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:66

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  40. Content type: Research

    The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning.

    Authors: Rosa Morabito, Concetta Alafaci, Stefano Pergolizzi, Antonio Pontoriero, Giuseppe Iati’, Lilla Bonanno, Michele Gaeta, Francesco Maria Salpietro, Enricomaria Mormina, Marcello Longo and Francesca Granata

    Citation: Radiation Oncology 2019 14:65

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  41. Content type: Research

    Patients with plasma-cell neoplasia usually suffer from systemic disease, although a minority (< 5%) may present with solitary involvement of bone or soft tissue (extramedullary plasmacytoma (EMP)). Radiothera...

    Authors: Michael Oertel, Khaled Elsayad, Kai Jannes Kroeger, Uwe Haverkamp, Claudia Rudack, Georg Lenz and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:63

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  42. Content type: Research

    This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

    Authors: Chih-Jen Huang, Ming-Yii Huang, Ming-Chen Paul Shih, Kai-yuan Cheng, Ka-Wo Lee, Tzu-Ying Lu, Shyng-Shiou Yuan and Pen-Tzu Fang

    Citation: Radiation Oncology 2019 14:61

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  43. Content type: Research

    Although there have been many attempts to increase the therapeutic ratio of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), only a few planning studies have reported the efficacy...

    Authors: Seo Hee Choi, So Hyun Park, Jason Joon Bock Lee, Jong Geol Baek, Jin Sung Kim and Hong In Yoon

    Citation: Radiation Oncology 2019 14:59

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  44. Content type: Review

    Advanced pelvic radiotherapy techniques aim to reduce late bowel toxicity which can severely impact the lives of pelvic cancer survivors. Although advanced techniques have been largely adopted worldwide, to ac...

    Authors: Rashmi Jadon, Emma Higgins, Louise Hanna, Mererid Evans, Bernadette Coles and John Staffurth

    Citation: Radiation Oncology 2019 14:57

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  45. Content type: Research

    It remains unknown which is the most preferable regimen used concurrently with thoracic radiation for locally advanced non-small cell lung cancer (NSCLC). We performed a network meta-analysis to address this i...

    Authors: Tingting Liu, Zheng He, Jun Dang and Guang Li

    Citation: Radiation Oncology 2019 14:55

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  46. Content type: Research

    To validate and propose revision of the 8th edition American Joint Committee on Cancer (AJCC) clinical staging system for esophageal squamous cell cancer (ESCC) patients treated with definitive intensity-modul...

    Authors: Mingqiu Chen, Xiqing Li, Yuangui Chen, Pingping Liu, Zhiwei Chen, Minmin Shen, Xiaohong Liu, Yu Lin, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Ye Tian, Junqiang Chen and Lengxi Fu

    Citation: Radiation Oncology 2019 14:54

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