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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Content type: Research

    The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursit...

    Authors: Oliver Micke, Eyup Ugrak, Stefan Bartmann, Irenaeus A. Adamietz, Ulrich Schaefer, Rebecca Bueker, Klaus Kisters, M. Heinrich Seegenschmiedt, Khashayar Fakhrian and Ralph Muecke

    Citation: Radiation Oncology 2018 13:71

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  2. Content type: Research

    Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictor...

    Authors: Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang and Guang Li

    Citation: Radiation Oncology 2018 13:69

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  3. Content type: Case report

    Total skin electron beam therapy (TSEBT) is an effective treatment in mycosis fungoides. Total skin helical tomotherapy (TSHT) may be an alternative to TSEBT and may offer several dosimetric and treatment adva...

    Authors: Eric M. Schaff, Stephen A. Rosenberg, Stephanie J. Olson, Steven P. Howard and Kristin A. Bradley

    Citation: Radiation Oncology 2018 13:67

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  4. Content type: Research

    We hypothesized that dominant intraprostatic lesions (DILs) could be depictured by multimodal imaging techniques (MRI and/or PSMA PET/CT) in patients with primary prostate cancer (PCa) and investigated possibl...

    Authors: Constantinos Zamboglou, Christina Marie Klein, Benedikt Thomann, Thomas Franz Fassbender, Hans C. Rischke, Simon Kirste, Karl Henne, Natalja Volegova-Neher, Michael Bock, Mathias Langer, Philipp T. Meyer, Dimos Baltas and Anca L. Grosu

    Citation: Radiation Oncology 2018 13:65

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  5. Content type: Research

    To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk...

    Authors: Per Munck af Rosenschold, Michael J. Zelefsky, Aditya P. Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke and Joseph O. Deasy

    Citation: Radiation Oncology 2018 13:64

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  6. Content type: Research

    Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial ...

    Authors: Donna H. Murrell, Joanna M. Laba, Abigail Erickson, Barbara Millman, David A. Palma and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:57

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  7. Content type: Research

    Meningiomas of the skull base account for 25–30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantia...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:54

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  8. Content type: Research

    68Ga-PSMA-PET-imaging has proven to be a highly sensitive and specific diagnostic element for patients with prostate cancer (PC). Does the standard clinical target volume (CTV) cover the majority of 68Ga-PSMA-PET...

    Authors: K. Schiller, M. Devecka, T. Maurer, M. Eiber, J. Gschwend, M. Schwaiger, S. E. Combs and G. Habl

    Citation: Radiation Oncology 2018 13:36

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  9. Content type: Study protocol

    Concurrent chemoradiotherapy is a standard modality for locally advanced esophageal squamous cell carcinoma (ESCC) patients. Cisplatin combined with 5-fluorouracil continuous infusion (PF) remains the standard...

    Authors: Yun Chen, Zhengfei Zhu, Weixin Zhao, Ling Li, Jinjun Ye, Chaoyang Wu, Huarong Tang, Qin Lin, Jiancheng Li, Yi Xia, Yunhai Li, Jialiang Zhou and Kuaile Zhao

    Citation: Radiation Oncology 2018 13:33

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  10. Content type: Research

    The purpose of this study was to evaluate the prognostic impact of Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) and Response Evaluation Criteria in Solid Tumors (RECIST) and of pre-...

    Authors: Cory Pierson, Taras Grinchak, Casey Sokolovic, Brandi Holland, Teresa Parent, Mark Bowling, Hyder Arastu, Paul Walker and Andrew Ju

    Citation: Radiation Oncology 2018 13:34

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  11. Content type: Case report

    Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment op...

    Authors: Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu and Thomas Brunner

    Citation: Radiation Oncology 2018 13:28

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  12. Content type: Research

    We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy.

    Authors: Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, Jin-Beom Chung, Keun-Yong Eom, Jae-Sung Kim, Chae-Yong Kim, Young Ho Park, Yu Jung Kim and In Ah Kim

    Citation: Radiation Oncology 2018 13:29

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  13. Content type: Research

    We evaluated dynamic changes in 18F–borono-L-phenylalanine (18F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neut...

    Authors: Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai and Jun Itami

    Citation: Radiation Oncology 2018 13:4

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  14. Content type: Research

    Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melano...

    Authors: Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck and David Kaul

    Citation: Radiation Oncology 2018 13:3

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  15. Content type: Research

    Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are...

    Authors: Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer and Christoph Henkenberens

    Citation: Radiation Oncology 2017 12:165

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  16. Content type: Research

    Stereotactic body radiotherapy (SBRT) is an emerging modality for definitive treatment of Hepatocellular carcinoma (HCC).

    Authors: Assaf Moore, Michal Cohen-Naftaly, Anna Tobar, Yulia Kundel, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eytan Mor, Michal Sarfaty, Dimitri Bragilovski, Ran Ben Hur, Noa Gordon, Salomon M. Stemmer and Aaron M. Allen

    Citation: Radiation Oncology 2017 12:163

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  17. Content type: Research

    Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body r...

    Authors: Michael C. Repka, Nima Aghdam, Shaan K. Kataria, Lloyd Campbell, Simeng Suy, Sean P. Collins, Eric Anderson, Jonathan W. Lischalk and Brian T. Collins

    Citation: Radiation Oncology 2017 12:162

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  18. Content type: Research

    The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of...

    Authors: Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa and Yasutaka Nakano

    Citation: Radiation Oncology 2017 12:160

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  19. Content type: Research

    Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investi...

    Authors: Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G. Moros, Matthew B. Schabath, Zhaoxiang Ye, Robert J. Gillies and Thomas J. Dilling

    Citation: Radiation Oncology 2017 12:158

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  20. Content type: Research

    The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.

    Authors: Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer and Piet Ost

    Citation: Radiation Oncology 2017 12:157

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