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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. To compare the efficacy and toxicity of hypofractionated radiotherapy versus conventional fractionated radiotherapy in postmastectomy breast cancer using meta-analysis.

    Authors: Lei Liu, Yongqiang Yang, Qi Guo, Bixin Ren, Qiliang Peng, Li Zou, Yaqun Zhu and Ye Tian

    Citation: Radiation Oncology 2020 15:17

    Content type: Review

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  2. The benefit of adjuvant radiotherapy (ART) for extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma (GBC) is unclear, with conflicting results from nonrandomized studies. We reported a meta-analysi...

    Authors: Bixin Ren, Qi Guo, Yongqiang Yang, Lei Liu, Shaohua Wei, Wei Chen and Ye Tian

    Citation: Radiation Oncology 2020 15:15

    Content type: Review

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  3. Limited stage small cell lung cancer (LS-SCLC) has a poor prognosis. Additional prognostic markers are needed for risk-stratification and treatment intensification. This study compares quantitative CT-based vo...

    Authors: Sophia C. Kamran, Thibaud Coroller, Nastaran Milani, Vishesh Agrawal, Elizabeth H. Baldini, Aileen B. Chen, Bruce E. Johnson, David Kozono, Idalid Franco, Nitish Chopra, Roman Zeleznik, Hugo J. W. L. Aerts and Raymond Mak

    Citation: Radiation Oncology 2020 15:14

    Content type: Research

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  4. Neoadjuvant external-beam radiotherapy (EBRT) with concomitant chemotherapy is the current standard-of-care for locally-advanced rectal cancer. Intraoperative radiotherapy (IORT) is to date only recommended fo...

    Authors: Sergey Potemin, Jens Kübler, Ivan Uvarov, Frederik Wenz and Frank Giordano

    Citation: Radiation Oncology 2020 15:11

    Content type: Research

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  5. Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, prolifera...

    Authors: Yang Tang, Li Yang, Wan Qin, Min’ Xiao Yi, Bo Liu and Xiang’Lin Yuan

    Citation: Radiation Oncology 2020 15:9

    Content type: Research

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  6. Definitive chemoradiotherapy (dCRT) is a standard treatment for patients with locally advanced head and neck cancer. There is a clinical need for a stratification of this prognostically heterogeneous group of ...

    Authors: Lars Schüttrumpf, Sebastian Marschner, Katrin Scheu, Julia Hess, Sibylle Rietzler, Axel Walch, Philipp Baumeister, Thomas Kirchner, Ute Ganswindt, Horst Zitzelsberger, Claus Belka and Cornelius Maihoefer

    Citation: Radiation Oncology 2020 15:7

    Content type: Research

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  7. mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tum...

    Authors: Kathrin Gennen, Lukas Käsmann, Julian Taugner, Chukwuka Eze, Monika Karin, Olarn Roengvoraphoj, Jens Neumann, Amanda Tufman, Michael Orth, Simone Reu, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:5

    Content type: Research

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  8. The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose o...

    Authors: Lihao Zhao, Xiaona Cai, Didi Chen, Xuxue Ye, Mengdan Gao, Lihuai Lu, Huafang Su, Meng Su, Meng Hou and Congying Xie

    Citation: Radiation Oncology 2019 15:3

    Content type: Research

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  9. Iodine seed implant brachytherapy is indicated for low risk and selected favorable intermediate risk prostate cancers. A percentage of positive biopsies > 50% is usually considered as a contra-indication, and ...

    Authors: Claire Meynard, Andres Huertas, Charles Dariane, Sandra Toublanc, Quentin Dubourg, Saik Urien, Marc-Olivier Timsit, Arnaud Méjean, Nicolas Thiounn and Philippe Giraud

    Citation: Radiation Oncology 2019 15:1

    Content type: Research

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  10. Volumetric Modulated Arc Therapy (VMAT) techniques have recently been implemented in clinical practice for total-body irradiation (TBI). To date, most techniques still use special couches, translational tables...

    Authors: Christoph Losert, Roel Shpani, Robert Kießling, Philipp Freislederer, Minglun Li, Franziska Walter, Maximilian Niyazi, Michael Reiner, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2019 14:244

    Content type: Research

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  11. Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative...

    Authors: Yolanda D. Tseng, Shadonna M. Maes, Gregory Kicska, Patricia Sponsellor, Erik Traneus, Tony Wong, Robert D. Stewart and Jatinder Saini

    Citation: Radiation Oncology 2019 14:243

    Content type: Research

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  12. The effectiveness of proton beam therapy (PBT) as initial treatment for patients with unresectable intrahepatic cholangiocarcinoma (ICC) is unclear, particularly as related to ICC histological subtypes. We per...

    Authors: Shosei Shimizu, Toshiyuki Okumura, Yoshiko Oshiro, Nobuyoshi Fukumitsu, Kuniaki Fukuda, Kazunori Ishige, Naoyuki Hasegawa, Haruko Numajiri, Keiko Murofushi, Kayoko Ohnishi, Masashi Mizumoto, Tetsuo Nonaka, Hitoshi Ishikawa and Hideyuki Sakurai

    Citation: Radiation Oncology 2019 14:241

    Content type: Research

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  13. As optic nerve sheath meningiomas (ONSM) are rare, there are no prospective studies. Our retrospective analysis focusses on a cohort of patients with uniform disease characteristics all treated with the same r...

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2019 14:240

    Content type: Research

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  14. conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

    Authors: Juliette Thariat, Julia Salleron, Celia Maschi, Edouard Fevrier, Sandra Lassalle, Lauris Gastaud, Stephanie Baillif, Audrey Claren, Florent Baumard, Joel Herault and Jean Pierre Caujolle

    Citation: Radiation Oncology 2019 14:239

    Content type: Research

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  15. Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence.

    Authors: Hikaru Kubota, Kayoko Tsujino, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Satoshi Yamaguchi and Ryohei Sasaki

    Citation: Radiation Oncology 2019 14:236

    Content type: Research

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  16. To update the clinical outcome of an elderly women cohort with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interst...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi

    Citation: Radiation Oncology 2019 14:234

    Content type: Short report

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  17. The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head m...

    Authors: Julian Mangesius, Thomas Seppi, Rocco Weigel, Christoph Reinhold Arnold, Danijela Vasiljevic, Georg Goebel, Peter Lukas, Ute Ganswindt and Meinhard Nevinny-Stickel

    Citation: Radiation Oncology 2019 14:231

    Content type: Research

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  18. How to protect the ovarian function during radiotherapy is uncertain. The purpose of this study was to explore the association between the location of the transposed ovary and the ovarian dose in patients with...

    Authors: Xiao-juan Lv, Xiao-long Cheng, Ye-qiang Tu, Ding-ding Yan and Qiu Tang

    Citation: Radiation Oncology 2019 14:230

    Content type: Research

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  19. The new staging system of cervical cancer issued in 2018 by the International Federation of Gynecology and Obstetrics (FIGO), calls for a new evaluation of the efficacy of prophylactic extended field irradiati...

    Authors: Qingyu Meng, Xiaoliang Liu, Weiping Wang, Xiaorong Hou, Xin Lian, Shuai Sun, Junfang Yan, Zhikai Liu, Zheng Miao, Fuquan Zhang and Ke Hu

    Citation: Radiation Oncology 2019 14:228

    Content type: Research

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  20. Current standard of treatment for newly diagnosed patients with glioblastoma (GBM) is surgical resection with adjuvant normofractionated radiotherapy (NFRT) combined with temozolomide (TMZ) chemotherapy. Hyper...

    Authors: Victor Lewitzki, Rainer J. Klement, Rebekka Kosmala, Dominik Lisowski, Michael Flentje and Bülent Polat

    Citation: Radiation Oncology 2019 14:227

    Content type: Research

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  21. To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-w...

    Authors: Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M. Ito, Nobuo Shinohara, Hiroki Shirato and Shinichi Shimizu

    Citation: Radiation Oncology 2019 14:226

    Content type: Research

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  22. The purpose of this study was to determine the associations between pathological complete remission (pCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) w...

    Authors: Kai Wang, Junlin Yi, Xiaodong Huang, Yuan Qu, Jingwei Luo, Jianping Xiao, Shiping Zhang, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Zhengang Xu, Shaoyan Liu and Xiaolei Wang

    Citation: Radiation Oncology 2019 14:225

    Content type: Research

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  23. The addition of regional nodal radiation (RNI) to whole breast irradiation for high risk breast cancer improves metastases free survival and new data suggests it contributes additional benefit to overall survi...

    Authors: Chloe Pandeli, Lloyd M. L. Smyth, Steven David and Andrew W. See

    Citation: Radiation Oncology 2019 14:223

    Content type: Research

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  24. Mast Cell Activation Syndrome (MCAS) is classified as an idiopathic mast cell disorder where inconsistent or unknown triggers release inflammatory mediators and cause a constellation of symptoms. Studies demon...

    Authors: Robin E. Landy, William C. Stross, Jackson M. May, Tasneem A. Kaleem, Timothy D. Malouff, Mark R. Waddle and Laura A. Vallow

    Citation: Radiation Oncology 2019 14:222

    Content type: Case report

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  25. The aim of this study was to explore the relationships between dosimetric parameters of organs at risk and patient-reported outcomes (PRO) after radiotherapy of patients with head and neck cancer.

    Authors: Toyokazu Hayakawa, Shogo Kawakami, Itaru Soda, Takuro Kainuma, Marika Nozawa, Akane Sekiguchi, Shunsuke Miyamoto, Taku Yamashita and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:221

    Content type: Research

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  26. A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translatin...

    Authors: Slavisa Tubin, Martin Ashdown and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:220

    Content type: Short report

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  27. The microscopic tumor spread (MS) beyond the macroscopic tumor borders of esophageal tumors is crucial for determining the clinical target volume (CTV) in radiotherapy. The question arises whether current volu...

    Authors: Melanie Machiels, Maurits L. van Montfoort, Nikki B. Thuijs, Mark I. van Berge Henegouwen, Tanja Alderliesten, Sybren L. Meijer, Jeanin E. van Hooft and Maarten C. C. M. Hulshof

    Citation: Radiation Oncology 2019 14:219

    Content type: Research

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  28. This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer.

    Authors: Jingwen Wang, Yun Guan, Weilie Gu, Senxiang Yan, Juying Zhou, Dan Huang, Tong Tong, Chao Li, Sanjun Cai, Zhen Zhang and Ji Zhu

    Citation: Radiation Oncology 2019 14:215

    Content type: Research

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  29. Accurate and standardized descriptions of organs at risk (OARs) are essential in radiation therapy for treatment planning and evaluation. Traditionally, physicians have contoured patient images manually, which...

    Authors: Sang Hee Ahn, Adam Unjin Yeo, Kwang Hyeon Kim, Chankyu Kim, Youngmoon Goh, Shinhaeng Cho, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Taeyoon Kim, Tae Hyun Kim, Sang Hee Youn, Eun Sang Oh and Jong Hwi Jeong

    Citation: Radiation Oncology 2019 14:213

    Content type: Research

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  30. Radiotherapy-induced lymphopenia may be limiting the success of therapy and could also negatively affect the ability of immune system in mediating the bystander (BE) and abscopal effects (AE). A novel SBRT-bas...

    Authors: Slavisa Tubin, Mohammad K. Khan, Gerardo Salerno, Waleed F. Mourad, Weisi Yan and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:212

    Content type: Methodology

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  31. To report dosimetry and early adverse effects, aesthetic, and patient-reported outcomes of a prospective study of 3-fraction pencil-beam scanning (PBS) proton accelerated partial irradiation (APBI).

    Authors: Robert W. Mutter, Krishan R. Jethwa, Karthik Gonuguntla, Nicholas B. Remmes, Thomas J. Whitaker, Tina J. Hieken, Kathryn J. Ruddy, Lisa A. McGee, Kimberly S. Corbin and Sean S. Park

    Citation: Radiation Oncology 2019 14:211

    Content type: Research

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  32. Small cell carcinoma of the esophagus (SCCE) is characterized by its progressive feature and poor prognosis. There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to charac...

    Authors: Baoqing Chen, Han Yang, Huali Ma, Qiaoqiao Li, Bo Qiu, Yonghong Hu and Yujia Zhu

    Citation: Radiation Oncology 2019 14:210

    Content type: Research

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  33. Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also be...

    Authors: Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki and Susumu Kanazawa

    Citation: Radiation Oncology 2019 14:209

    Content type: Research

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  34. Despite increasing clinical data suggest that internal mammary node (IMN) irradiation would improve local-regional control and overall survival in breast cancer, its role remains controversial due to increased...

    Authors: Yujie Wang, Weixiang Qi, Haoping Xu, Miao Zhang, Yimin Han, Jiayi Chen and Cheng Xu

    Citation: Radiation Oncology 2019 14:208

    Content type: Research

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  35. To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiat...

    Authors: Xiyin Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, Lin Kong and Jiade J. Lu

    Citation: Radiation Oncology 2019 14:206

    Content type: Research

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  36. Some patients experience oligo-progression during androgen receptor targeted therapy (ARTT) treatments. This progression might not indicate a real systemic drug resistance, but a selective monoclonal resistanc...

    Authors: Maurizio Valeriani, Luca Marinelli, Serena Macrini, Chiara Reverberi, Anna Maria Aschelter, Vitaliana De Sanctis, Paolo Marchetti, Lidia Tronnolone and Mattia Falchetto Osti

    Citation: Radiation Oncology 2019 14:205

    Content type: Research

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  37. Breast cancer (BC) radiotherapy (RT) can induce cardiotoxicity, with adverse events often observed many years after BC RT. Subclinical left ventricular (LV) dysfunction can be detected early after BC RT with g...

    Authors: Valentin Walker, Olivier Lairez, Olivier Fondard, Atul Pathak, Baptiste Pinel, Christian Chevelle, Denis Franck, Gaëlle Jimenez, Jérémy Camilleri, Loïc Panh, David Broggio, Sylvie Derreumaux, Marie-Odile Bernier, Dominique Laurier, Jean Ferrières and Sophie Jacob

    Citation: Radiation Oncology 2019 14:204

    Content type: Research

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  38. To determine the prognostic effect of adjuvant radiation and clinicopathological variables in surgically treated patients with small cell carcinoma of the cervix (SCCC).

    Authors: Ting Shen, Yan-hui Jiang, Yao-yao Zou, Fang-fang Qiu, Xing-sheng Qiu and Kai-yun You

    Citation: Radiation Oncology 2019 14:203

    Content type: Research

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  39. The objective of this investigation is to evaluate the outcomes and toxicity of carbon-ion re-irradiation (CIR) in patients with rare head and neck cancers (HNC). There is a paucity of data regarding treatment...

    Authors: Thomas Held, Paul Windisch, Sati Akbaba, Kristin Lang, Benjamin Farnia, Jakob Liermann, Denise Bernhardt, Peter Plinkert, Christian Freudlsperger, Stefan Rieken, Klaus Herfarth, Jürgen Debus and Sebastian Adeberg

    Citation: Radiation Oncology 2019 14:202

    Content type: Research

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  40. This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hF...

    Authors: Conti Alfredo, Senger Carolin, Acker Güliz, Kluge Anne, Pontoriero Antonio, Cacciola Alberto, Pergolizzi Stefano, Germanò Antonino, Badakhshi Harun, Kufeld Markus, Meinert Franziska, Nguyen Phuong, Loebel Franziska, Vajkoczy Peter, Budach Volker and Kaul David

    Citation: Radiation Oncology 2019 14:201

    Content type: Research

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  41. The purpose of this study was to evaluate the outcomes of elderly patients (aged ≥75 years) with newly diagnosed glioblastoma (GBM), who were treated with hypofractionated radiotherapy comprising 45 Gy in 15 f...

    Authors: Makoto Ohno, Yasuji Miyakita, Masamichi Takahashi, Hiroshi Igaki, Yuko Matsushita, Koichi Ichimura and Yoshitaka Narita

    Citation: Radiation Oncology 2019 14:200

    Content type: Research

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  42. Postradiogenic wound healing disorders are an important clinical problem. While a variety of treatment modalities are available, there is no strategy to objectively judge treatment success. The aim of this stu...

    Authors: Steffen Auerswald, Stephan Schreml, Robert Meier, Alexandra Blancke Soares, Maximilian Niyazi, Sebastian Marschner, Claus Belka, Martin Canis and Frank Haubner

    Citation: Radiation Oncology 2019 14:199

    Content type: Research

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  43. Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART ...

    Authors: Marco M. E. Vogel, Kerstin A. Kessel, Kilian Schiller, Michal Devecka, Jürgen E. Gschwend, Wilko Weichert, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:198

    Content type: Research

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  44. The appropriate timing of radiotherapy (RT) for patients after radical prostatectomy (RP) with adverse pathological features (APFs) remains controversial. This systematic review was conducted to compare the ef...

    Authors: Ronggui Tao, Jindong Dai, Yunjin Bai, Jiyu Yang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Hao Zeng and Pengfei Shen

    Citation: Radiation Oncology 2019 14:197

    Content type: Review

    Published on:

  45. To compare irradiation dose to the second and third portions of duodenum (Duo2 and Duo3) with a new refined and old delineation method of para-aortic region for patients with locally advanced cervical cancer (...

    Authors: Bo Yang, Xiaoliang Liu, Ke Hu, Jie Qiu, Fuquan Zhang, Xiaorong Hou, Junfang Yan, Qingyu Meng, Weiping Wang, Lang Yu and Yijun Wang

    Citation: Radiation Oncology 2019 14:196

    Content type: Research

    Published on:

  46. The optimal treatment for elderly patients with early-stage non-small cell lung cancer (NSCLC) remains inconclusive. Previous studies have shown that stereotactic body radiotherapy (SBRT) provides encouraging ...

    Authors: Baiqiang Dong, Jin Wang, Xuan Zhu, Yuanyuan Chen, Yujin Xu, Kainan Shao, Lei Zheng, Hangjie Ying, Ming Chen and Jianping Cao

    Citation: Radiation Oncology 2019 14:195

    Content type: Research

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  47. We aimed to ascertain population-based practice patterns and survival outcomes of postoperative radiotherapy following breast conserving-surgery (BCS) in elderly women (aged ≥65 years) with early-stage pure mu...

    Authors: San-Gang Wu, Feng-Yan Li, Jun Wang, Chen-Lu Lian, Juan Zhou and Zhen-Yu He

    Citation: Radiation Oncology 2019 14:190

    Content type: Research

    Published on:

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