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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...

    Authors: T. Bostel, C. Dreher, D. Wollschläger, A. Mayer, F. König, S. Bickelhaupt, H. P. Schlemmer, P. E. Huber, F. Sterzing, P. Bäumer, J. Debus and N. H. Nicolay

    Citation: Radiation Oncology 2020 15:171

    Content type: Research

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  2. Immune-checkpoint inhibitors (ICI) have dramatically changed the landscape of lung cancer treatment. Preclinical studies investigating combination of ICI with radiation show a synergistic improvement of tumor ...

    Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Maurice Dantes, Nina-Sophie Schmidt-Hegemann, Sanziana Schiopu, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:167

    Content type: Review

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  3. Starting in December 2019, the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confronts the world with an unprecedented challenge. With no vaccine or drug being cur...

    Authors: Sebastian Marschner, Stefanie Corradini, Josefine Rauch, Richard Zacharias, Ana Sujic, Julia Mayerle, Raluca Petru, Béatrice Grabein, Oliver T. Keppler, Edwin Boelke, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2020 15:165

    Content type: Research

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  4. Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton radiotherapy in treating hepatocellular carcinoma (HCC). However, cl...

    Authors: Jen-Yu Cheng, Chieh-Min Liu, Yu-Ming Wang, Hsuan-Chih Hsu, Eng-Yen Huang, Tzu-Ting Huang, Ching-Hsin Lee, Sheng-Ping Hung and Bing-Shen Huang

    Citation: Radiation Oncology 2020 15:159

    Content type: Research

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  5. Postoperative radiation therapy for soft tissue sarcomas demonstrated good local recurrence-free survival rates and survival outcomes. However, the results remained controversial. This study aimed to evaluate ...

    Authors: Xinmiao Yang, Lihua Zhang, Xiaojing Yang, Weiwei Yu and Jie Fu

    Citation: Radiation Oncology 2020 15:158

    Content type: Review

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  6. The purpose of this study was to determine the potential of escalated dose radiation (EDR) robust intensity-modulated proton radiotherapy (ro-IMPT) in reducing GI toxicity risk in locally advanced unresectable...

    Authors: Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano and Tetsuo Akimoto

    Citation: Radiation Oncology 2020 15:157

    Content type: Research

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  7. The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory o...

    Authors: Yun-Hsuan Lin, Shih-Ming Huang, Wing-Keen Yap, Ju-Wen Yang, Ling Yeung, Din-Li Tsan, Joseph Tung-Chieh Chang and Lung-Chien Chen

    Citation: Radiation Oncology 2020 15:156

    Content type: Research

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  8. The objectives of this study were to determine the objective effective response rate, survival, and safety of radiotherapy combined with gefitinib in patients with locally advanced non-small cell lung cancer (...

    Authors: Zhixue Fu, Xu Yang, Wenqing Wang, Lei Deng, Tao Zhang, Nan Bi, Xiaozhen Wang, Dongfu Chen, Zongmei Zhou, Luhua Wang and Jun Liang

    Citation: Radiation Oncology 2020 15:155

    Content type: Research

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  9. Even though frequent, it is not known how HIV infection and treatment impact in the consolidation by radiotherapy of non-Hodgkin diffuse large B-cell lymphomas (DBCL). This article aim to assess that differenc...

    Authors: Carolina Trindade Mello Medici, Geovanne Pedro Mauro, Lucas Coelho Casimiro and Eduardo Weltman

    Citation: Radiation Oncology 2020 15:153

    Content type: Research

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  10. Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT).

    Authors: Davide Cusumano, Jennifer Dhont, Luca Boldrini, Giuditta Chiloiro, Angela Romano, Claudio Votta, Silvia Longo, Lorenzo Placidi, Luigi Azario, Marco De Spirito, Dirk Verellen and Vincenzo Valentini

    Citation: Radiation Oncology 2020 15:152

    Content type: Research

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  11. Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxici...

    Authors: Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan and Maria A. Hawkins

    Citation: Radiation Oncology 2020 15:151

    Content type: Study protocol

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  12. Retrospective analysis of volumetric modulated arc therapy treatment plans to investigate qualitative, possible, clinical consequences of the use of AAA versus AXB in nasopharyngeal cancer (NPC) cases.

    Authors: Antonella Bufacchi, Orietta Caspiani, Giulia Rambaldi, Luca Marmiroli, Giuseppe Giovinazzo and Mattia Polsoni

    Citation: Radiation Oncology 2020 15:150

    Content type: Research

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  13. Loco-regional and distant failure are common in inoperable stage III non small-cell lung cancer (NSCLC) after chemoradiotherapy (CRT). However, there is limited real-world data on failure pattern, patient prog...

    Authors: Julian Taugner, Chukwuka Eze, Lukas Käsmann, Olarn Roengvoraphoj, Kathrin Gennen, Monika Karin, Oleg Petrukhnov, Amanda Tufman, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:148

    Content type: Research

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  14. There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the r...

    Authors: Anna Embring, Eva Onjukka, Claes Mercke, Ingmar Lax, Anders Berglund, Sara Bornedal, Berit Wennberg and Signe Friesland

    Citation: Radiation Oncology 2020 15:147

    Content type: Research

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  15. At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide 125I seed implantation f...

    Authors: Xiangmeng He, Ming Liu, Menglong Zhang, Roberto Blanco Sequeiros, Yujun Xu, Ligang Wang, Chao Liu, Qingwen Wang, Kai Zhang and Chengli Li

    Citation: Radiation Oncology 2020 15:146

    Content type: Research

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  16. Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been test...

    Authors: Jane-Chloe Trone, Alexis Vallard, Sandrine Sotton, Majed Ben Mrad, Omar Jmour, Nicolas Magné, Benjamin Pommier, Silvy Laporte and Edouard Ollier

    Citation: Radiation Oncology 2020 15:145

    Content type: Review

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  17. Desmoid-type fibromatosis is a rare, potentially locally aggressive disease. Herein we present our experience in the treatment with radiotherapy.

    Authors: K. Seidensaal, S. B. Harrabi, F. Weykamp, K. Herfarth, T. Welzel, G. Mechtersheimer, B. Lehner, M. Schneider, S. Fröhling, G. Egerer, J. Debus and M. Uhl

    Citation: Radiation Oncology 2020 15:143

    Content type: Research

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  18. Radiation-induced choanal stenosis (RICS) severely decreases life quality of patients with nasopharyngeal carcinoma (NPC) and originates from nasal mucositis, which depends on radiation dose. This self-control...

    Authors: Hui Chang, Kai Chen, Ya-lan Tao, Fei Han, Wei-jun Ye and Yuan-hong Gao

    Citation: Radiation Oncology 2020 15:142

    Content type: Research

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  19. To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on th...

    Authors: Dirk Vordermark

    Citation: Radiation Oncology 2020 15:140

    Content type: Short report

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  20. Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma (PDAC), and its therapeutic role remains unclear. The objective of t...

    Authors: Saber Amin, Michael Baine, Jane Meza, Morshed Alam and Chi Lin

    Citation: Radiation Oncology 2020 15:139

    Content type: Research

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  21. Developments in the field of proton beam therapy (PBT) have recently crossed the tipping point wherein the modality is now more versatile than ever before, with possibilities and likely indications expanding r...

    Authors: Srinivas Chilukuri, Pankaj Kumar Panda and Rakesh Jalali

    Citation: Radiation Oncology 2020 15:138

    Content type: Commentary

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  22. Circulating tumor cells (CTCs) are an established prognostic marker in castration-resistant prostate cancer but have received little attention in localized high-risk disease. We studied the detection rate of C...

    Authors: Almudena Zapatero, Antonio Gómez-Caamaño, María Ángeles Cabeza Rodriguez, Laura Muinelo-Romay, Carmen Martin de Vidales, Alicia Abalo, Patricia Calvo Crespo, Luis Leon Mateos, Carlos Olivier and Lorena Vega Vega Piris

    Citation: Radiation Oncology 2020 15:137

    Content type: Research

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  23. To validate the Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast cancer nodal clinical target volumes (CTVs) and to investigate the Radiotherapy Compara...

    Authors: Laura Beaton, Luminita Nica, Scott Tyldesley, Kenny Sek, Gareth Ayre, Maria Aparicio, Lovedeep Gondara, Caroline Speers and Alan Nichol

    Citation: Radiation Oncology 2020 15:136

    Content type: Research

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  24. Melanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed treatment of stereotactic radiotherapy (SRT) and whole brain radiotherapy (W...

    Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…

    Citation: Radiation Oncology 2020 15:135

    Content type: Research

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  25. Fatigue is one of the most common and distressing side-effects of breast cancer radiotherapy. According to current guidelines, accelerated partial breast irradiation (APBI) may be considered as an alternative ...

    Authors: Tobias Forster, Cornelia Jäkel, Sati Akbaba, David Krug, Robert Krempien, Matthias Uhl, Matthias Felix Häfner, Laila König, Stefan Alexander Koerber, Semi Harrabi, Denise Bernhardt, Rouven Behnisch, Johannes Krisam, Andre Hennigs, Christof Sohn, Jörg Heil…

    Citation: Radiation Oncology 2020 15:134

    Content type: Study protocol

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  26. Endoscopic resection is widely used as an effective treatment for superficial esophageal cancer. However, the risk of lymph node metastasis increases in cases of muscularis mucosae or deeper invasion, for whic...

    Authors: Ikuno Nishibuchi, Yuji Murakami, Yoshinori Adachi, Nobuki Imano, Yuki Takeuchi, Ippei Tkahashi, Tomoki Kimura, Yuji Urabe, Shiro Oka, Shinji Tanaka and Yasushi Nagata

    Citation: Radiation Oncology 2020 15:133

    Content type: Research

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  27. Hypofractionated-SRS (HF-SRS) may allow for improved local control and a reduced risk of radiation necrosis compared to single-fraction-SRS (SF-SRS). However, data comparing these two treatment approaches are ...

    Authors: Jill S. Remick, Emily Kowalski, Rahul Khairnar, Kai Sun, Emily Morse, Hua-Ren R. Cherng, Yannick Poirier, Narottam Lamichhane, Stewart J. Becker, Shifeng Chen, Akshar N. Patel, Young Kwok, Elizabeth Nichols, Pranshu Mohindra, Graeme F. Woodworth, William F. Regine…

    Citation: Radiation Oncology 2020 15:128

    Content type: Research

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  28. Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer.

    Authors: Yosuke Takakusagi, Hiroyuki Katoh, Kio Kano, Wataru Anno, Keisuke Tsuchida, Nobutaka Mizoguchi, Itsuko Serizawa, Daisaku Yoshida and Tadashi Kamada

    Citation: Radiation Oncology 2020 15:127

    Content type: Research

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  29. To evaluate the impact of primary tumor radiotherapy on survival in patients with unresectable metastatic rectal or rectosigmoid cancer.

    Authors: Gang Wang, Wenling Wang, Haijie Jin, Hongmin Dong, Weiwei Chen, Xiaokai Li, Guodong Li and Leilei Li

    Citation: Radiation Oncology 2020 15:126

    Content type: Research

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  30. Anal cancer is a rare disease, which might be the reason for the “one size fits all” approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contempo...

    Authors: Martin P. Nilsson, Erik D. Nilsson, Anders Johnsson, Otilia Leon, Adalsteinn Gunnlaugsson and Jonas Scherman

    Citation: Radiation Oncology 2020 15:125

    Content type: Research

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  31. To investigate the loco-regional progression-free survival (LPFS) of intensity-modulated radiotherapy (IMRT) with different fraction sizes for locally advanced non-small-cell lung cancer (LANSCLC), and to appl...

    Authors: Bo Qiu, Qi Wen Li, Xin Lei Ai, Bin Wang, Jian Huan, Zheng Fei Zhu, Gen Hua Yu, Ming Ji, Hai Hang Jiang, Cheng Li, Jun Zhang, Li Chen, Jin Yu Guo, Yin Zhou and Hui Liu

    Citation: Radiation Oncology 2020 15:124

    Content type: Research

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  32. To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).

    Authors: Ryo Toya, Tetsuo Saito, Kohsei Yamaguchi, Tomohiko Matsuyama, Takahiro Watakabe, Tadashi Matsumoto, Ryoji Yoshida, Akiyuki Hirosue, Daizo Murakami, Yorihisa Orita, Hideki Nakayama and Natsuo Oya

    Citation: Radiation Oncology 2020 15:123

    Content type: Research

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  33. Patients with left-sided breast cancer frequently receive deep inspiration breath-hold (DIBH) radiotherapy to reduce the risk of cardiac side effects. The aim of the present study was to analyze intra-breath-h...

    Authors: D. Reitz, F. Walter, S. Schönecker, P. Freislederer, M. Pazos, M. Niyazi, G. Landry, F. Alongi, E. Bölke, C. Matuschek, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2020 15:121

    Content type: Research

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  34. After esophagectomy, adjuvant chemotherapy (S + CT) and adjuvant chemoradiotherapy (S + CRT) can improve survival in patients with node-positive resectable esophageal cancer. However, we are not aware of any s...

    Authors: Qifeng Wang, Jinyi Lang, Tao Li, Lin Peng, Wei Dai, Yinchun Jiang, Tianpeng Xie, Qiang Fang, Yi Wang, Lei Wu, Bangrong Cao and Yongtao Han

    Citation: Radiation Oncology 2020 15:119

    Content type: Research

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  35. Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Surgical resection is the standard treatment for localized ACC, but the local recurrence remains high. Adjuvant radiation (ART) has be...

    Authors: Jiawei Zhu, Ziye Zheng, Jing Shen, Xin Lian, Zheng Miao, Jie Shen and Fuquan Zhang

    Citation: Radiation Oncology 2020 15:118

    Content type: Research

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  36. Patients with left-sided breast cancer have an increased risk of cardiovascular disease (CVD) after radiotherapy (RT). While the awareness of cardiac toxicity has increased enormously over the last decade, the...

    Authors: Aurélie Gaasch, Stephan Schönecker, Cristoforo Simonetto, Markus Eidemüller, Montserrat Pazos, Daniel Reitz, Maya Rottler, Philipp Freislederer, Michael Braun, Rachel Würstlein, Nadia Harbeck, Maximilian Niyazi, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:117

    Content type: Research

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  37. Sarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including pati...

    Authors: Romain Mallet, Romain Modzelewski, Justine Lequesne, Sorina Mihailescu, Pierre Decazes, Hugues Auvray, Ahmed Benyoucef, Fréderic Di Fiore, Pierre Vera, Bernard Dubray and Sébastien Thureau

    Citation: Radiation Oncology 2020 15:116

    Content type: Research

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  38. Stereotactic radiosurgery (SRS) is an effective treatment for trigeminal neuralgia (TN). Nevertheless, a proportion of patients will experience recurrence and treatment-related sensory disturbances. In order t...

    Authors: Alfredo Conti, Gueliz Acker, Antonio Pontoriero, Juliane Hardt, Anne Kluge, Alberto Cacciola, Giuseppe Iatì, Markus Kufeld, Volker Budach, Peter Vajkoczy, Giancarlo Beltramo, Stefano Pergolizzi, Achille Bergantin, Franziska Loebel, Silvana Parisi, Carolin Senger…

    Citation: Radiation Oncology 2020 15:115

    Content type: Research

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  39. We evaluated whether pre- and mid-treatment metabolic tumor volume (MTV) predicts per lesion local recurrence (LR) in patients treated with definitive radiation therapy (RT, dose≥60 Gy) for locally advanced no...

    Authors: Michael S. Binkley, Julie L. Koenig, Mehr Kashyap, Michael Xiang, Yufei Liu, Quaovi Sodji, Peter G. Maxim, Maximilian Diehn, Billy W. Loo Jr and Michael F. Gensheimer

    Citation: Radiation Oncology 2020 15:114

    Content type: Research

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  40. The number of nonagenarian cancer patients (≥ 90 years) is continuously increasing, and radiotherapy is performed in a relevant proportion of patients, as surgery and chemotherapy are often not feasible for th...

    Authors: Tanja Sprave, Alexander Rühle, Raluca Stoian, Alina Weber, Constantinos Zamboglou, Carsten Nieder, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:113

    Content type: Research

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  41. To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.

    Authors: Hans Geinitz, Carsten Nieder, Lukas Kocik, Christine Track, Johann Feichtinger, Theresa Weingartner, Kurt Spiegl, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Dietmar H. Seewald, Reinhold Függer, Andreas Shamiyeh, Andreas L. Petzer, David Kiesl and Josef Hammer

    Citation: Radiation Oncology 2020 15:111

    Content type: Research

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  42. Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-en...

    Authors: Gustavo R. Sarria, Vera Petrova, Frederik Wenz, Yasser Abo-Madyan, Elena Sperk and Frank A. Giordano

    Citation: Radiation Oncology 2020 15:110

    Content type: Research

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  43. Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with ...

    Authors: Dan Wang, Chongshun Liu, Yuan Zhou, Tingyu Yan, Chenglong Li, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Cenap Güngör and Yuqiang Li

    Citation: Radiation Oncology 2020 15:107

    Content type: Research

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