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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.

    Authors: Meng Ni, Aijun Jiang, Wenju Liu, Yanxing Sheng, Haiyan Zeng, Ning Liu, Qingxiao Gao, Yong Wang, Jinming Yu and Shuanghu Yuan

    Citation: Radiation Oncology 2020 15:70

    Content type: Research

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  2. Unity Elekta is a unique magnetic resonance (MR)-linac that conjugates a 1.5 Tesla MR unit with a 7 MV flattening filter free accelerator.A prospective observational study for the clinical use of Elekta Unity ...

    Authors: Filippo Alongi, Michele Rigo, Vanessa Figlia, Francesco Cuccia, Niccolò Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Rosario Mazzola

    Citation: Radiation Oncology 2020 15:69

    Content type: Research

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  3. We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and ...

    Authors: Ling Zhou, Jia Chen, Wei Shen, Zheng-Lu Chen, Shuang Huang, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu and Yuan-Yuan Chen

    Citation: Radiation Oncology 2020 15:68

    Content type: Research

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  4. This study directs to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone versus IMRT plus chemotherapy in intermediate-risk NPC (stage II and T3N0M0).

    Authors: Omer Aftab, Shufang Liao, Rongjun Zhang, Nan Tang, Meiqing Luo, Bin Zhang, Sanjeev Shahi, Raju Rai, Jazib Ali and Wei Jiang

    Citation: Radiation Oncology 2020 15:66

    Content type: Research

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  5. We evaluated the relationship between patient-, tumor-, and treatment-related features and radiation-induced lymphopenia (RIL) and evaluated the correlation between RIL and survival outcome in NPC patients to ...

    Authors: Xiaoxue Xie, Shenglan Gong, Hekun Jin, Pei Yang, Ting Xu, Yilong Cai, Chengxian Guo, Rong Zhang, Fan Lou, Wenjuan Yang and Hui Wang

    Citation: Radiation Oncology 2020 15:65

    Content type: Research

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  6. To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs).

    Authors: Jianmin Liu, Rafael Rojas, Fred C. Lam, Farhan A. Mirza, Anand Mahadevan and Ekkehard M. Kasper

    Citation: Radiation Oncology 2020 15:63

    Content type: Research

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  7. Advances in therapy have resulted in improved cure rates and an increasing number of long-term Hodgkin's lymphoma (HL) survivors. However, radiotherapy (RT)-related late effects are still a significant issue, ...

    Authors: Andrea Riccardo Filippi, Sofia Meregalli, Anna DI Russo, Mario Levis, Patrizia Ciammella, Michela Buglione, Andrea Emanuele Guerini, Giuseppina De Marco, Vitaliana De Sanctis, Stefano Vagge, Umberto Ricardi and Gabriele Simontacchi

    Citation: Radiation Oncology 2020 15:62

    Content type: Review

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  8. Limiting the heart dose in left sided breast cancer radiotherapy is critical. We sought to study the effect of using CPAP (continuous positive airway pressure) as an aid in reducing heart dose in breast cancer...

    Authors: Aaron M. Allen, Yasmin Korzets Ceder, Tzippy Shochat, Eyal Fenig, Aron Popovtzer, Dimitry Bragilofsky, Adi Alfassy and Helena Allon

    Citation: Radiation Oncology 2020 15:59

    Content type: Research

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  9. The aim of the present study was to evaluate MRI response rate and clinical outcome of short-course radiotherapy (SCRT) on rectal cancer as an alternative to chemoradiotherapy in patients where downstaging is ...

    Authors: T. Koëter, S. G. C. van Elderen, G. F. A. J. B. van Tilborg, J. H. W. de Wilt, D. K. Wasowicz, T. Rozema and D. D. E. Zimmerman

    Citation: Radiation Oncology 2020 15:53

    Content type: Research

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  10. Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we ar...

    Authors: Konstantin Christoph Koban, Lucas Etzel, Zhouxiao Li, Montserrat Pazos, Stephan Schönecker, Claus Belka, Riccardo Enzo Giunta, Thilo Ludwig Schenck and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:52

    Content type: Research

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  11. For stereotactic body radiotherapy (SBRT) to central (C) and ultracentral (UC) lung tumors, our provincial practice has been to prioritize organs at risk (OARs) constraints by compromising target volume covera...

    Authors: Yizhou Zhao, Eman Khawandanh, Steven Thomas, Susan Zhang, Emma M. Dunne, Mitchell Liu and Devin Schellenberg

    Citation: Radiation Oncology 2020 15:61

    Content type: Research

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  12. Neoadjuvant radiotherapy (RT) has been shown to improve local control; however, whether it can improve overall survival (OS) in locally advanced rectal cancer (LARC) patients remains controversial. We therefor...

    Authors: Feng Zhao, Jili Wang, Hao Yu, Xiaofei Cheng, Xinke Li, Xuan Zhu, Xiangming Xu, Jianjiang Lin, Xin Chen and Senxiang Yan

    Citation: Radiation Oncology 2020 15:49

    Content type: Research

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  13. The literature regarding pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy (IMRT) for esophageal cancer was lacking. This study aimed to investigate the risk fa...

    Authors: Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng and Forn-Chia Lin

    Citation: Radiation Oncology 2020 15:48

    Content type: Research

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  14. To investigate the consequences of residual setup error on target dose distribution using various image registration strategies for breast cancer treated with intensity-modulated proton therapy (IMPT).

    Authors: Xiaoying Liang, Raymond B. Mailhot Vega, Zuofeng Li, Dandan Zheng, Nancy Mendenhall and Julie A. Bradley

    Citation: Radiation Oncology 2020 15:47

    Content type: Research

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  15. To analyze patterns of failure in patients with LA-NSCLC who received definitive chemoradiotherapy (CRT) and to build a nomogram for predicting the failure patterns in this population of patients.

    Authors: Xueru Zhu, Runping Hou, Xiaoyang Li, Chang Jiang, Wuyan Xia and Xiaolong Fu

    Citation: Radiation Oncology 2020 15:43

    Content type: Research

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  16. On the elastic profiles of human teeth after radiotherapy for head and neck cancers, generation of dental complications, which may bring several side effects preventing the quality of life, has not well clarif...

    Authors: Irem Demirkan, Gokhan Yaprak, Cemile Ceylan, Emriye Algul, Ceyda Ozcakir Tomruk, Bukem Bilen and Mehmet Burcin Unlu

    Citation: Radiation Oncology 2020 15:38

    Content type: Research

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  17. There is limited data on the use of targeted or immunotherapy (TT/IT) in combination with single fraction stereotactic radiosurgery (SRS) in patients with melanoma brain metastasis (MBM). Therefore, we analyze...

    Authors: Indrawati Hadi, Olarn Roengvoraphoj, Raphael Bodensohn, Jan Hofmaier, Maximilian Niyazi, Claus Belka and Silke Birgit Nachbichler

    Citation: Radiation Oncology 2020 15:37

    Content type: Research

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  18. The development of radiation pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT) is known to be associated with many different factors, although historical analyses of RP have commonly utilized hetero...

    Authors: Jeffrey M. Ryckman, Michael Baine, Joseph Carmicheal, Ferdinand Osayande, Richard Sleightholm, Kaeli Samson, Dandan Zheng, Weining Zhen, Chi Lin and Chi Zhang

    Citation: Radiation Oncology 2020 15:33

    Content type: Research

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  19. In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important el...

    Authors: Rasmus Lübeck Christiansen, Lars Dysager, Anders Smedegaard Bertelsen, Olfred Hansen, Carsten Brink and Uffe Bernchou

    Citation: Radiation Oncology 2020 15:32

    Content type: Research

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  20. Head-and-neck squamous cell carcinoma (HNSCC) is one of the most common malignancies globally, and the number of elderly patients diagnosed with HNSCC is increasing. However, as elderly HNSCC patients are unde...

    Authors: Erik Haehl, Alexander Rühle, Hélène David, Tobias Kalckreuth, Tanja Sprave, Raluca Stoian, Christoph Becker, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:31

    Content type: Research

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  21. Local ablative treatment strategies are frequently offered to patients diagnosed with oligometastatic disease. Stereotactic body radiotherapy (SBRT), as ablative treatment option, is well established for lung ...

    Authors: Laila König, Matthias F. Häfner, Sonja Katayama, Stefan A. Koerber, Eric Tonndorf-Martini, Denise Bernhardt, Bastian von Nettelbladt, Fabian Weykamp, Philipp Hoegen, Sebastian Klüter, Matthew S. Susko, Jürgen Debus and Juliane Hörner-Rieber

    Citation: Radiation Oncology 2020 15:30

    Content type: Research

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  22. Colorectal cancer treatment requires a complex, multidisciplinary approach. Because of the potential variability, monitoring through clinical audits is advisable. This study assesses the effects of a quality i...

    Authors: M. G. Torras, E. Canals, C. Muñoz-Montplet, A. Vidal, D. Jurado, A. Eraso, S. Villà, M. Caro, J. Molero, M. Macià, M. Puigdemont, E. González-Muñoz, A. López, F. Guedea and J. M. Borras

    Citation: Radiation Oncology 2020 15:28

    Content type: Research

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  23. Small inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and r...

    Authors: Christian Schaefer, Constantinos Zamboglou, Natalja Volegova-Neher, Carmen Martini, Nils Henrik Nicolay, Nina-Sophie Schmidt-Hegemann, Paul Rogowski, Minglun Li, Claus Belka, Arndt-Christian Müller, Anca-Ligia Grosu and Thomas Brunner

    Citation: Radiation Oncology 2020 15:27

    Content type: Research

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  24. Single session radiosurgery represents a widely accepted treatment for intracranial meningiomas. However, this approach could involve a high risk of treatment-related complications when applied to large volume...

    Authors: V. Pinzi, M. Marchetti, E. De Martin, V. Cuccarini, I. Tramacere, F. Ghielmetti, M. L. Fumagalli, C. Iezzoni and L. Fariselli

    Citation: Radiation Oncology 2020 15:26

    Content type: Study protocol

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  25. To evaluate the long-term efficacy and toxicity of radiation therapy in patients with Stage IE primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.

    Authors: Masanari Niwa, Satoshi Ishikura, Kotoha Tatekawa, Natsuko Takama, Akifumi Miyakawa, Toshinobu Kubota, Eriko Kato and Yuta Shibamoto

    Citation: Radiation Oncology 2020 15:25

    Content type: Research

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  26. Stereotactic Ablative Radiotherapy (SABR) is an effective treatment that improves local control for many tumours. However, the role of SABR in gynecological cancers (GYN) has not been well-established. We hypo...

    Authors: E. Leung, A. Gladwish, A. Sahgal, S. S. Lo, C. A. Kunos, R. M. Lanciano, C. A. Mantz, M. Guckenberger, T. M. Zagar, N. A. Mayr, A. R. Chang, S. Jorcano, T. Biswas, A. Pontoriero and K. V. Albuquerque

    Citation: Radiation Oncology 2020 15:24

    Content type: Research

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  27. Curative intent therapy of stage II NSCLC may include surgical resection or definitive radiotherapy. Primary management with surgery or radiotherapy may be influenced by patient and disease characteristics. We...

    Authors: Sara Moore, Bonnie Leung, Jonn Wu and Cheryl Ho

    Citation: Radiation Oncology 2020 15:23

    Content type: Research

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  28. There is a lack of data on the biologically effective dose and the efficacy of stereotactic body radiotherapy in hepatocellular carcinoma patients, and this study was conducted to explore the relation between ...

    Authors: Jing Sun, Aimin Zhang, Wengang Li, Quan Wang, Dong Li, Dan Zhang and Xuezhang Duan

    Citation: Radiation Oncology 2020 15:20

    Content type: Study protocol

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  29. Distant Metastases from Head and Neck Squamous cell carcinomas are uncommon (9–11%) and they are usually found in the lung and less frequently in the liver, kidney and adrenals.

    Authors: Agostino Cristaudo, Antonio Stefanelli, Stefano Ursino, Durim Delishaj, Davide Baldaccini, Alessandra Gonnelli and Fabiola Paiar

    Citation: Radiation Oncology 2020 15:18

    Content type: Case report

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  30. To compare the efficacy and toxicity of hypofractionated radiotherapy versus conventional fractionated radiotherapy in postmastectomy breast cancer using meta-analysis.

    Authors: Lei Liu, Yongqiang Yang, Qi Guo, Bixin Ren, Qiliang Peng, Li Zou, Yaqun Zhu and Ye Tian

    Citation: Radiation Oncology 2020 15:17

    Content type: Review

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  31. The benefit of adjuvant radiotherapy (ART) for extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma (GBC) is unclear, with conflicting results from nonrandomized studies. We reported a meta-analysi...

    Authors: Bixin Ren, Qi Guo, Yongqiang Yang, Lei Liu, Shaohua Wei, Wei Chen and Ye Tian

    Citation: Radiation Oncology 2020 15:15

    Content type: Review

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  32. Limited stage small cell lung cancer (LS-SCLC) has a poor prognosis. Additional prognostic markers are needed for risk-stratification and treatment intensification. This study compares quantitative CT-based vo...

    Authors: Sophia C. Kamran, Thibaud Coroller, Nastaran Milani, Vishesh Agrawal, Elizabeth H. Baldini, Aileen B. Chen, Bruce E. Johnson, David Kozono, Idalid Franco, Nitish Chopra, Roman Zeleznik, Hugo J. W. L. Aerts and Raymond Mak

    Citation: Radiation Oncology 2020 15:14

    Content type: Research

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  33. Neoadjuvant external-beam radiotherapy (EBRT) with concomitant chemotherapy is the current standard-of-care for locally-advanced rectal cancer. Intraoperative radiotherapy (IORT) is to date only recommended fo...

    Authors: Sergey Potemin, Jens Kübler, Ivan Uvarov, Frederik Wenz and Frank Giordano

    Citation: Radiation Oncology 2020 15:11

    Content type: Research

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  34. Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, prolifera...

    Authors: Yang Tang, Li Yang, Wan Qin, Min’ Xiao Yi, Bo Liu and Xiang’Lin Yuan

    Citation: Radiation Oncology 2020 15:9

    Content type: Research

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  35. Definitive chemoradiotherapy (dCRT) is a standard treatment for patients with locally advanced head and neck cancer. There is a clinical need for a stratification of this prognostically heterogeneous group of ...

    Authors: Lars Schüttrumpf, Sebastian Marschner, Katrin Scheu, Julia Hess, Sibylle Rietzler, Axel Walch, Philipp Baumeister, Thomas Kirchner, Ute Ganswindt, Horst Zitzelsberger, Claus Belka and Cornelius Maihoefer

    Citation: Radiation Oncology 2020 15:7

    Content type: Research

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  36. mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tum...

    Authors: Kathrin Gennen, Lukas Käsmann, Julian Taugner, Chukwuka Eze, Monika Karin, Olarn Roengvoraphoj, Jens Neumann, Amanda Tufman, Michael Orth, Simone Reu, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:5

    Content type: Research

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  37. The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose o...

    Authors: Lihao Zhao, Xiaona Cai, Didi Chen, Xuxue Ye, Mengdan Gao, Lihuai Lu, Huafang Su, Meng Su, Meng Hou and Congying Xie

    Citation: Radiation Oncology 2019 15:3

    Content type: Research

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  38. Iodine seed implant brachytherapy is indicated for low risk and selected favorable intermediate risk prostate cancers. A percentage of positive biopsies > 50% is usually considered as a contra-indication, and ...

    Authors: Claire Meynard, Andres Huertas, Charles Dariane, Sandra Toublanc, Quentin Dubourg, Saik Urien, Marc-Olivier Timsit, Arnaud Méjean, Nicolas Thiounn and Philippe Giraud

    Citation: Radiation Oncology 2019 15:1

    Content type: Research

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  39. Volumetric Modulated Arc Therapy (VMAT) techniques have recently been implemented in clinical practice for total-body irradiation (TBI). To date, most techniques still use special couches, translational tables...

    Authors: Christoph Losert, Roel Shpani, Robert Kießling, Philipp Freislederer, Minglun Li, Franziska Walter, Maximilian Niyazi, Michael Reiner, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2019 14:244

    Content type: Research

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  40. Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative...

    Authors: Yolanda D. Tseng, Shadonna M. Maes, Gregory Kicska, Patricia Sponsellor, Erik Traneus, Tony Wong, Robert D. Stewart and Jatinder Saini

    Citation: Radiation Oncology 2019 14:243

    Content type: Research

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  41. The effectiveness of proton beam therapy (PBT) as initial treatment for patients with unresectable intrahepatic cholangiocarcinoma (ICC) is unclear, particularly as related to ICC histological subtypes. We per...

    Authors: Shosei Shimizu, Toshiyuki Okumura, Yoshiko Oshiro, Nobuyoshi Fukumitsu, Kuniaki Fukuda, Kazunori Ishige, Naoyuki Hasegawa, Haruko Numajiri, Keiko Murofushi, Kayoko Ohnishi, Masashi Mizumoto, Tetsuo Nonaka, Hitoshi Ishikawa and Hideyuki Sakurai

    Citation: Radiation Oncology 2019 14:241

    Content type: Research

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  42. As optic nerve sheath meningiomas (ONSM) are rare, there are no prospective studies. Our retrospective analysis focusses on a cohort of patients with uniform disease characteristics all treated with the same r...

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2019 14:240

    Content type: Research

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  43. conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

    Authors: Juliette Thariat, Julia Salleron, Celia Maschi, Edouard Fevrier, Sandra Lassalle, Lauris Gastaud, Stephanie Baillif, Audrey Claren, Florent Baumard, Joel Herault and Jean Pierre Caujolle

    Citation: Radiation Oncology 2019 14:239

    Content type: Research

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  44. Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence.

    Authors: Hikaru Kubota, Kayoko Tsujino, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Satoshi Yamaguchi and Ryohei Sasaki

    Citation: Radiation Oncology 2019 14:236

    Content type: Research

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  45. To update the clinical outcome of an elderly women cohort with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interst...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi

    Citation: Radiation Oncology 2019 14:234

    Content type: Short report

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  46. The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head m...

    Authors: Julian Mangesius, Thomas Seppi, Rocco Weigel, Christoph Reinhold Arnold, Danijela Vasiljevic, Georg Goebel, Peter Lukas, Ute Ganswindt and Meinhard Nevinny-Stickel

    Citation: Radiation Oncology 2019 14:231

    Content type: Research

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