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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. Intensity-modulated radiation therapy (IMRT) and volume-modulated arc therapy (VMAT) are rather complex treatment techniques and require patient-specific quality assurance procedures. Electronic portal imaging...

    Authors: Jun Zhang, Xiuqing Li, Miaomiao Lu, Qilin Zhang, Xile Zhang, Ruijie Yang, Maria F. Chan and Junhai Wen

    Citation: Radiation Oncology 2021 16:232

    Content type: Research

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  2. This study presents patient-specific quality assurance (QA) results from the first 395 clinical cases for the new helical TomoTherapy® platform (Radixact) coupled with dedicated Precision TPS.

    Authors: Marco Fusella, Samuele Cavinato, Alessandra Germani, Marta Paiusco, Nicola Pivato, Marco Andrea Rossato, Anthony Scott and Alessandro Scaggion

    Citation: Radiation Oncology 2021 16:226

    Content type: Research

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  3. To communicate our institutional experience with single isocenter radiosurgery treatments for multiple brain metastases, including challenges with determining planning target volume (PTV) margins and resulting...

    Authors: Nzhde Agazaryan, Steve Tenn, Chul Lee, Michael Steinberg, John Hegde, Robert Chin, Nader Pouratian, Isaac Yang, Won Kim and Tania Kaprealian

    Citation: Radiation Oncology 2021 16:221

    Content type: Research

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  4. To implement a tangential treatment technique for whole breast irradiation using the Varian Halcyon and to compare it with Elekta Synergy Agility plans.

    Authors: Anne Richter, Sonja Wegener, Kathrin Breuer, Gary Razinskas, Stefan Weick, Florian Exner, Klaus Bratengeier, Michael Flentje, Otto Sauer and Bülent Polat

    Citation: Radiation Oncology 2021 16:213

    Content type: Research

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  5. In the existing application of beam-matched multiroom proton therapy system, the model based on the commissioning data from the leading treatment room was used as the shared model. The purpose of this study is...

    Authors: Yu-Hua Huang, Chunfeng Fang, Tao Yang, Lin Cao, Gaolong Zhang, Baolin Qu, Yihang Zhang, Zishen Wang and Shouping Xu

    Citation: Radiation Oncology 2021 16:206

    Content type: Research

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  6. Evaluation of delivered dose to the dominant intraprostatic lesion (DIL) for moderately hypofractionated radiotherapy of prostate cancer by cone beam computed tomography (CBCT)-based dose accumulation and targ...

    Authors: Jörg Tamihardja, Sinan Cirsi, Patrick Kessler, Gary Razinskas, Florian Exner, Anne Richter, Bülent Polat and Michael Flentje

    Citation: Radiation Oncology 2021 16:205

    Content type: Research

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  7. To develop high-quality synthetic CT (sCT) generation method from low-dose cone-beam CT (CBCT) images by using attention-guided generative adversarial networks (AGGAN) and apply these images to dose calculatio...

    Authors: Liugang Gao, Kai Xie, Xiaojin Wu, Zhengda Lu, Chunying Li, Jiawei Sun, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2021 16:202

    Content type: Research

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  8. Hypoxia is known to be prevalent in solid tumors such as non-small cell lung cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET imaging can provide in-vivo hypoxia measurements...

    Authors: Andreas Köthe, Nicola Bizzocchi, Sairos Safai, Antony John Lomax, Damien Charles Weber and Giovanni Fattori

    Citation: Radiation Oncology 2021 16:199

    Content type: Research

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  9. In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potenti...

    Authors: Duncan den Boer, Johannes K. Veldman, Geertjan van Tienhoven, Arjan Bel and Zdenko van Kesteren

    Citation: Radiation Oncology 2021 16:188

    Content type: Research

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  10. We aimed to assess the feasibility of a dose painting (DP) procedure, known as simultaneous integrated boost intensity modulated radiation Therapy (SIB-IMRT), for treating prostate cancer with dominant intrapr...

    Authors: Seyed Masoud Rezaeijo, Bijan Hashemi, Bahram Mofid, Mohsen Bakhshandeh, Arash Mahdavi and Mohammad Saber Hashemi

    Citation: Radiation Oncology 2021 16:182

    Content type: Research

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  11. Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been a critical issue in this process. An atlas-based automatic segmentation w...

    Authors: Yuka Urago, Hiroyuki Okamoto, Tomoya Kaneda, Naoya Murakami, Tairo Kashihara, Mihiro Takemori, Hiroki Nakayama, Kotaro Iijima, Takahito Chiba, Junichi Kuwahara, Shouichi Katsuta, Satoshi Nakamura, Weishan Chang, Hidetoshi Saitoh and Hiroshi Igaki

    Citation: Radiation Oncology 2021 16:175

    Content type: Research

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  12. To compare the dosimetric, normal tissue complication probability (NTCP), secondary cancer complication probabilities (SCCP), and excess absolute risk (EAR) differences of volumetric modulated arc therapy (VMA...

    Authors: Yun Zhang, Yuling Huang, Shenggou Ding, Xingxing Yuan, Yuxian Shu, Jinhui Liang, Qingfeng Mao, Chunling Jiang and Jingao Li

    Citation: Radiation Oncology 2021 16:171

    Content type: Research

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  13. To evaluate the combined effect of rotational error and dose gradient on target dose coverage in frameless stereotactic radiotherapy.

    Authors: Jai-Woong Yoon, Soah Park, Kwang-Ho Cheong, Sei-Kwon Kang and Tae Jin Han

    Citation: Radiation Oncology 2021 16:169

    Content type: Research

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  14. The objective of this study was to analyze the amplitude of translational and rotational movements occurring during stereotactic body radiotherapy (SBRT) of spinal metastases in two different positioning devic...

    Authors: Ahmed Hadj Henni, David Gensanne, Maximilien Roge, Chantal Hanzen, Guillaume Bulot, Elyse Colard and Sebastien Thureau

    Citation: Radiation Oncology 2021 16:168

    Content type: Research

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  15. To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

    Authors: Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu, Yanhua Duan, Aihui Feng and Zhiyong Xu

    Citation: Radiation Oncology 2021 16:158

    Content type: Research

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  16. Patient-specific dose prediction improves the efficiency and quality of radiation treatment planning and reduces the time required to find the optimal plan. In this study, a patient-specific dose prediction mo...

    Authors: Sang Hee Ahn, EunSook Kim, Chankyu Kim, Wonjoong Cheon, Myeongsoo Kim, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Dae Yong Kim and Jong Hwi Jeong

    Citation: Radiation Oncology 2021 16:154

    Content type: Research

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  17. Inter-modality image registration between computed tomography (CT) and magnetic resonance (MR) images is associated with systematic uncertainties and the magnitude of these uncertainties is not well documented...

    Authors: Emilia Persson, Sevgi Emin, Jonas Scherman, Christian Jamtheim Gustafsson, Patrik Brynolfsson, Sofie Ceberg, Adalsteinn Gunnlaugsson and Lars E. Olsson

    Citation: Radiation Oncology 2021 16:150

    Content type: Research

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  18. To compare the clinical outcomes of stereotactic body radiation therapy (SBRT) and fractionated radiation therapy (FRT) for primary liver cancer with portal vein tumor thrombus (PVTT).

    Authors: Sujing Zhang, Li He, Changwen Bo, Shufang Yang, Yonghui An, Na Li, Yingchun Zhao, Liping Zhao, Wenhua Ma and Zheng Zheng

    Citation: Radiation Oncology 2021 16:149

    Content type: Research

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  19. A range pull-back device, such as a machine-related range shifter (MRS) or a universal patient-related range shifter (UPRS), is needed in pencil beam scanning technique to treat shallow tumors.

    Authors: Haibo Lin, Chengyu Shi, Sheng Huang, Jiajian Shen, Minglei Kang, Qing Chen, Huifang Zhai, James McDonough, Zelig Tochner, Curtiland Deville, Charles B. Simone II and Stefan Both

    Citation: Radiation Oncology 2021 16:146

    Content type: Research

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  20. Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different ada...

    Authors: Miriam Eckl, Gustavo R. Sarria, Sandra Springer, Marvin Willam, Arne M. Ruder, Volker Steil, Michael Ehmann, Frederik Wenz and Jens Fleckenstein

    Citation: Radiation Oncology 2021 16:145

    Content type: Research

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  21. To use cone-beam computed tomography (CBCT) imaging to determine the impacts of patient characteristics on the magnitude of geometric setup errors and obtain patient-specific planning target volume (PTV) margi...

    Authors: Jurui Luo, Zhihai Yin, Zhen Zhang, Xiaomao Guo, Xiaoli Yu and Juanqi Wang

    Citation: Radiation Oncology 2021 16:143

    Content type: Research

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  22. Quality assurance (QA) of treatment plans in clinical trials improves protocol compliance and patient outcomes. Retrospective use of knowledge-based-planning (KBP) in clinical trials has demonstrated improved ...

    Authors: Nicholas Hardcastle, Olivia Cook, Xenia Ray, Alisha Moore, Kevin L. Moore, David Pryor, Alana Rossi, Farshad Foroudi, Tomas Kron and Shankar Siva

    Citation: Radiation Oncology 2021 16:142

    Content type: Research

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  23. Mega-voltage fan-beam Computed Tomography (MV-FBCT) holds potential in accurate determination of relative electron density (RED) and proton stopping power ratio (SPR) but is not widely available.

    Authors: Hao Gong, Shengzhen Tao, Justin D. Gagneur, Wei Liu, Jiajian Shen, Cynthia H. McCollough, Yanle Hu and Shuai Leng

    Citation: Radiation Oncology 2021 16:139

    Content type: Research

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  24. Online adaptive radiotherapy has the potential to reduce toxicity for patients treated for rectal cancer because smaller planning target volumes (PTV) margins around the entire clinical target volume (CTV) are...

    Authors: Rianne de Jong, Jorrit Visser, Niek van Wieringen, Jan Wiersma, Debby Geijsen and Arjan Bel

    Citation: Radiation Oncology 2021 16:136

    Content type: Research

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  25. This study aimed to (1) develop a fully residual deep convolutional neural network (CNN)-based segmentation software for computed tomography image segmentation of the male pelvic region and (2) demonstrate its...

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Pascal Baillehache, Yusuke Fujimoto, Shota Nakagawa, Yusuke Saruya, Tatsumasa Kabasawa and Takashi Mizowaki

    Citation: Radiation Oncology 2021 16:135

    Content type: Research

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  26. Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the corr...

    Authors: Zhengwen Shen, Xia Tan, Shi Li, Xiumei Tian, Huanli Luo, Ying Wang and Fu Jin

    Citation: Radiation Oncology 2021 16:134

    Content type: Research

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  27. The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac)...

    Authors: Vanessa Da Silva Mendes, Lukas Nierer, Minglun Li, Stefanie Corradini, Michael Reiner, Florian Kamp, Maximilian Niyazi, Christopher Kurz, Guillaume Landry and Claus Belka

    Citation: Radiation Oncology 2021 16:133

    Content type: Research

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  28. To establish regression models of physical and equivalent dose in 2 Gy per fraction (EQD2) plan parameters of two kinds of hybrid planning for stage III NSCLC.

    Authors: Hao Wang, Yongkang Zhou, Wutian Gan, Hua Chen, Ying Huang, Yanhua Duan, Aihui Feng, Yan Shao, Hengle Gu, Qing Kong and Zhiyong Xu

    Citation: Radiation Oncology 2021 16:119

    Content type: Research

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  29. The purpose of this study is to comprehensively evaluate the suitability of Gafchromic EBT3 and EBT-XD film for dosimetric quality assurance in 0.35 T MR-guided radiotherapy.

    Authors: Ilma Xhaferllari, Joshua P. Kim, Ruchira Liyanage, Chang Liu, Dongsu Du, Anthony Doemer, Indrin J. Chetty and Ning Wen

    Citation: Radiation Oncology 2021 16:117

    Content type: Research

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  30. 125I seed implantation has been found to show good therapeutic effects on tumors. Recent studies showed that three-dimensional (3D) print template-assisted 125I seed implantation can optimize radiation dose distr...

    Authors: Enli Chen, Yuwei Zhang, Hongtao Zhang, Chenfei Jia, Yansong Liang and Juan Wang

    Citation: Radiation Oncology 2021 16:115

    Content type: Review

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  31. Daily anatomical deviations may distort the dose distribution in carbon ion radiotherapy (CIRT), which may cause treatment failure. Therefore, this study aimed to perform re-planning to maintain the dose cover...

    Authors: Yang Li, Yoshiki Kubota, Masahiko Okamoto, Shintaro Shiba, Shohei Okazaki, Toshiaki Matsui, Mutsumi Tashiro, Takashi Nakano and Tatsuya Ohno

    Citation: Radiation Oncology 2021 16:111

    Content type: Research

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  32. To investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of vari...

    Authors: Luca Cozzi, Sushil Beriwal, Esa Kuusela, Supriya Chopra, Hester Burger, Nanette Joubert, Antonella Fogliata, Jai Prakash Agarwal and Pat Kupelian

    Citation: Radiation Oncology 2021 16:110

    Content type: Research

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  33. The purpose of this study is to develop a clinical application program that automatically calculates the effect for secondary cancer risk (SCR) of individual patient. The program was designed based on accurate...

    Authors: Dong-Jin Kang, Young-Joo Shin, Seonghoon Jeong, Jae-Yong Jung, Hakjae Lee and Boram Lee

    Citation: Radiation Oncology 2021 16:108

    Content type: Research

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  34. We investigated the geometric and dosimetric impact of three-dimensional (3D) generative adversarial network (GAN)-based metal artifact reduction (MAR) algorithms on volumetric-modulated arc therapy (VMAT) and...

    Authors: Mitsuhiro Nakamura, Megumi Nakao, Keiho Imanishi, Hideaki Hirashima and Yusuke Tsuruta

    Citation: Radiation Oncology 2021 16:96

    Content type: Research

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  35. The Polaris product line from Northern Digital Inc. is well known for accurate optical tracking measurements in research and medical environments. The Spectra position sensor, to date often found in image guid...

    Authors: Giovanni Fattori, Antony John Lomax, Damien Charles Weber and Sairos Safai

    Citation: Radiation Oncology 2021 16:87

    Content type: Short report

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  36. To improve split-VMAT technique by optimizing treatment delivery time for deep-inspiration breath hold (DIBH) radiotherapy in left-sided breast cancer patients, when automatic beam-interruption devices are not...

    Authors: Sara Poeta, Younes Jourani, Alex De Caluwé, Robbe Van den Begin, Dirk Van Gestel and Nick Reynaert

    Citation: Radiation Oncology 2021 16:77

    Content type: Research

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  37. Most studies on synthetic computed tomography (sCT) generation for brain rely on in-house developed methods. They often focus on performance rather than clinical feasibility. Therefore, the aim of this work wa...

    Authors: Minna Lerner, Joakim Medin, Christian Jamtheim Gustafsson, Sara Alkner, Carl Siversson and Lars E. Olsson

    Citation: Radiation Oncology 2021 16:66

    Content type: Research

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  38. This work addresses a basic inconsistency in the way dose is accumulated in radiotherapy when predicting the biological effect based on the linear quadratic model (LQM). To overcome this inconsistency, we intr...

    Authors: Nina I. Niebuhr, Mona Splinter, Tilman Bostel, Joao Seco, Clemens M. Hentschke, Ralf O. Floca, Juliane Hörner-Rieber, Markus Alber, Peter Huber, Nils H. Nicolay and Asja Pfaffenberger

    Citation: Radiation Oncology 2021 16:65

    Content type: Methodology

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  39. To explore whether a highly refined dose volume histograms (DVH) prediction model can improve the accuracy and reliability of knowledge-based volumetric modulated arc therapy (VMAT) planning for cervical cancer.

    Authors: Mingli Wang, Huikuan Gu, Jiang Hu, Jian Liang, Sisi Xu and Zhenyu Qi

    Citation: Radiation Oncology 2021 16:58

    Content type: Research

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  40. Whole brain radiation (WBRT) may lead to acute xerostomia and dry eye from incidental parotid and lacrimal exposure, respectively. We performed a prospective observational study to assess the incidence/severit...

    Authors: Panayiotis Mavroidis, Kevin A. Pearlstein, Dominic H. Moon, Victoria Xu, Trevor J. Royce, Ashley A. Weiner, Colette J. Shen, Lawrence B. Marks, Bhishamjit S. Chera, Shiva K. Das and Kyle Wang

    Citation: Radiation Oncology 2021 16:56

    Content type: Research

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  41. Variation in target positioning represents a challenge to set-up reproducibility and reliability of dose delivery with stereotactic body radiation therapy (SBRT) for pancreatic adenocarcinoma (PDAC). While on-...

    Authors: Colin S. Hill, Sarah Han-Oh, Zhi Cheng, Ken Kang-Hsin Wang, Jeffrey J. Meyer, Joseph M. Herman and Amol K. Narang

    Citation: Radiation Oncology 2021 16:53

    Content type: Research

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  42. This study aimed to quantify errors by using a cine electronic portal imaging device (cine EPID) during deep inspiration breath-hold (DIBH) for left-sided breast cancer and to estimate the planning target volu...

    Authors: Yuka Ono, Michio Yoshimura, Tomohiro Ono, Takahiro Fujimoto, Yuki Miyabe, Yukinori Matsuo and Takashi Mizowaki

    Citation: Radiation Oncology 2021 16:49

    Content type: Research

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  43. To compare linac-based mono-isocentric radiosurgery with Brainlab Elements Multiple Brain Mets (MBM) SRS and the Gamma Knife using a specific statistical method and to analyze the dosimetric impact of the targ...

    Authors: Michel Chea, Karen Fezzani, Julian Jacob, Marguerite Cuttat, Mathilde Croisé, Jean-Marc Simon, Loïc Feuvret, Charles-Ambroise Valery, Philippe Maingon, Mohamed-Amine Benadjaoud and Catherine Jenny

    Citation: Radiation Oncology 2021 16:45

    Content type: Research

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  44. The Halcyon is a new machine from the Varian company. The purpose of this study was to evaluate the dosimetry of the Halcyon in treatment of bilateral breast cancer with volumetric modulated arc therapy.

    Authors: Tao Sun, Xiutong Lin, Guifang Zhang, Qingtao Qiu, Chengqiang Li and Yong Yin

    Citation: Radiation Oncology 2021 16:35

    Content type: Research

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  45. Proton therapy is a promising advancement in radiation oncology especially in terms of reducing normal tissue toxicity, although it is currently expensive and of limited availability. Here we estimated the ind...

    Authors: N. Patrik Brodin, Rafi Kabarriti, Clyde B. Schechter, Mark Pankuch, Vinai Gondi, Shalom Kalnicki, Madhur K. Garg and Wolfgang A. Tomé

    Citation: Radiation Oncology 2021 16:19

    Content type: Research

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  46. Surface-guided radiation therapy can be used to continuously monitor a patient’s surface motions during radiotherapy by a non-irradiating, noninvasive optical surface imaging technique. In this study, machine ...

    Authors: Guangyu Wang, Zhibin Li, Guangjun Li, Guyu Dai, Qing Xiao, Long Bai, Yisong He, Yaxin Liu and Sen Bai

    Citation: Radiation Oncology 2021 16:13

    Content type: Research

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  47. Whole brain radiotherapy (WBRT) can impair patients’ cognitive function. Hippocampal avoidance during WBRT can potentially prevent this side effect. However, manually delineating the target area is time-consum...

    Authors: Kaicheng Pan, Lei Zhao, Song Gu, Yi Tang, Jiahao Wang, Wen Yu, Lucheng Zhu, Qi Feng, Ruipeng Su, Zhiyong Xu, Xiadong Li, Zhongxiang Ding, Xiaolong Fu, Shenglin Ma, Jun Yan, Shigong Kang…

    Citation: Radiation Oncology 2021 16:12

    Content type: Research

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  48. We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) ...

    Authors: Liwen Zhang, Weiwei Wang, Jiyi Hu, Jiade Lu and Lin Kong

    Citation: Radiation Oncology 2020 15:277

    Content type: Research

    Published on:

  49. An O-ring gantry-type linear accelerator (LINAC) with a 6-MV flattening filter-free (FFF) photon beam, Halcyon, includes a reference beam that contains representative information such as the percent depth dose...

    Authors: Min-Geon Choi, Martin Law, Do-Kun Yoon, Mikoto Tamura, Kenji Matsumoto, Masakazu Otsuka, Moo-Sub Kim, Shih-Kien Djeng, Hajime Monzen and Tae Suk Suh

    Citation: Radiation Oncology 2020 15:273

    Content type: Research

    Published on:

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