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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. To develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency a...

    Authors: Xiao Wang, Chi Ma, Rihan Davis, Rahul R. Parikh, Salma K. Jabbour, Bruce G. Haffty, Ning J. Yue, Ke Nie and Yin Zhang

    Citation: Radiation Oncology 2019 14:224

    Content type: Research

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  2. In order to locate an arteriovenous malformation, typically, a digital subtraction angiography (DSA) is carried out. To use the DSA for target definition an accurate image registration between CT and DSA is re...

    Authors: Daniel Schmidhalter, Dominik Henzen, Evelyn Herrmann, Werner Volken, Paul-Henry Mackeprang, Ekin Ermis, Hossein Hemmatazad, Jonas Honegger, Benjamin Haas, Michael K. Fix and Peter Manser

    Citation: Radiation Oncology 2019 14:217

    Content type: Research

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  3. PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characte...

    Authors: Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti and Stefano Tomatis

    Citation: Radiation Oncology 2019 14:216

    Content type: Research

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  4. The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spa...

    Authors: Masayoshi Yamada, Hiraku Sato, Yoshiro Ieko, Yuya Miyasaka, Takayuki Kanai, Natsuko Yano, Takashi Ono, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Yasushi Teranishi, Yasuhiro Kikuchi and Kenji Nemoto

    Citation: Radiation Oncology 2019 14:207

    Content type: Research

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  5. Stereotactic body radiation therapy (SBRT) was found effective in treating laryngeal cancer with only five treatment fractions by a recent clinical trial (NCT01984502, ClinicalTrials.gov). Nevertheless, this t...

    Authors: You Zhang, Tsuicheng Chiu, Jeffrey Dubas, Zhen Tian, Pam Lee, Xuejun Gu, Yulong Yan, David Sher, Robert Timmerman and Bo Zhao

    Citation: Radiation Oncology 2019 14:193

    Content type: Research

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  6. Patients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prom...

    Authors: Louise Belshaw, Christina E. Agnew, Denise M. Irvine, Keith P. Rooney and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:189

    Content type: Research

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  7. To determine if the performance of a knowledge based RapidPlan (RP) planning model could be improved with an iterative learning process, i.e. if plans generated by an RP model could be used as new input to re-...

    Authors: A. Fogliata, L. Cozzi, G. Reggiori, A. Stravato, F. Lobefalo, C. Franzese, D. Franceschini, S. Tomatis and M. Scorsetti

    Citation: Radiation Oncology 2019 14:187

    Content type: Research

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  8. To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects.

    Authors: Kilian-Simon Baumann, Veronika Flatten, Uli Weber, Stefan Lautenschläger, Fabian Eberle, Klemens Zink and Rita Engenhart-Cabillic

    Citation: Radiation Oncology 2019 14:183

    Content type: Research

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  9. Vendor-independent Monte Carlo (MC) dose calculation (IDC) for patient-specific quality assurance of multi-leaf collimator (MLC) based CyberKnife treatments is used to benchmark and validate the commercial MC ...

    Authors: P.-H. Mackeprang, D. Vuong, W. Volken, D. Henzen, D. Schmidhalter, M. Malthaner, S. Mueller, D. Frei, W. Kilby, D. M. Aebersold, M. K. Fix and P. Manser

    Citation: Radiation Oncology 2019 14:172

    Content type: Research

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  10. To provide fast and accurate dose calculation in voxelized geometries for proton radiation therapy by implementing an adaptive step size algorithm in the proton macro Monte Carlo (pMMC) method.

    Authors: Reto Kueng, Daniel Frei, Werner Volken, Fabian Stuermlin, Marco F. M. Stampanoni, Daniel M. Aebersold, Peter Manser and Michael K. Fix

    Citation: Radiation Oncology 2019 14:165

    Content type: Research

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  11. The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials const...

    Authors: David Hoffman, Irena Dragojević, Jeremy Hoisak, David Hoopes and Ryan Manger

    Citation: Radiation Oncology 2019 14:162

    Content type: Research

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  12. Target localization in radiation therapy is affected by numerous sources of uncertainty. Despite measures to minimize the breathing motion, the treatment of hypofractionated liver radiation therapy is further ...

    Authors: Gye Won Choi, Yelin Suh, Prajnan Das, Joseph Herman, Emma Holliday, Eugene Koay, Albert C. Koong, Sunil Krishnan, Bruce D. Minsky, Grace L. Smith, Cullen M. Taniguchi and Sam Beddar

    Citation: Radiation Oncology 2019 14:154

    Content type: Research

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  13. Heterogeneous target doses are a common by-product from attempts to improve normal tissue sparing in radiosurgery treatment planning. These regions of escalated dose within the target may increase tumor contro...

    Authors: William T. Hrinivich, Todd R. McNutt and Jeffrey J. Meyer

    Citation: Radiation Oncology 2019 14:145

    Content type: Research

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  14. This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system.

    Authors: Jung-in Kim, Jong Min Park, Chang Heon Choi, Hyun Joon An, Yi-Jun Kim and Jin Ho Kim

    Citation: Radiation Oncology 2019 14:139

    Content type: Research

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  15. To quantify the dosimetric parameters of different bone marrow sparing strategies and to determine the optimal strategy for cervical cancer patients undergoing postoperative intensity-modulated radiotherapy (I...

    Authors: Zhirong Bao, Dajiang Wang, Shupeng Chen, Min Chen, Dazhen Jiang, Chunxu Yang, Hui Liu, Jing Dai and Conghua Xie

    Citation: Radiation Oncology 2019 14:118

    Content type: Research

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  16. Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby

    Citation: Radiation Oncology 2019 14:134

    Content type: Review

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  17. The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita

    Citation: Radiation Oncology 2019 14:133

    Content type: Research

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  18. To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee

    Citation: Radiation Oncology 2019 14:131

    Content type: Research

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  19. To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang

    Citation: Radiation Oncology 2019 14:129

    Content type: Research

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  20. Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study pres...

    Authors: J. Visser, P. de Boer, K. F. Crama, Z. van Kesteren, C. R. N. Rasch, L. J. A. Stalpers and A. Bel

    Citation: Radiation Oncology 2019 14:126

    Content type: Research

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  21. To determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Secondly, to evaluat...

    Authors: Vincent C. Hamming, Christa Visser, Estelle Batin, Leah N. McDermott, Dianne M. Busz, Stefan Both, Johannes A. Langendijk and Nanna M. Sijtsema

    Citation: Radiation Oncology 2019 14:125

    Content type: Research

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  22. Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated t...

    Authors: Stewart Mein, Ivana Dokic, Carmen Klein, Thomas Tessonnier, Till Tobias Böhlen, Guiseppe Magro, Julia Bauer, Alfredo Ferrari, Katia Parodi, Thomas Haberer, Jürgen Debus, Amir Abdollahi and Andrea Mairani

    Citation: Radiation Oncology 2019 14:123

    Content type: Research

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  23. To calculate the individualized fraction regime (IFR) in stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) patients using the uncomplicated tumor control probability (UTCP, P+) function...

    Authors: Jia-Yang Lu, Pei-Xian Lin and Bao-Tian Huang

    Citation: Radiation Oncology 2019 14:111

    Content type: Research

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  24. The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues

    Citation: Radiation Oncology 2019 14:108

    Content type: Methodology

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  25. In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2019 14:103

    Content type: Research

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  26. Liver tumors are subject to motion with respiration, which is typically accounted for by increasing the target volume. The prescription dose is often reduced to keep the mean liver dose under a threshold level...

    Authors: M. Gargett, C. Haddad, A. Kneebone, J. T. Booth and N. Hardcastle

    Citation: Radiation Oncology 2019 14:93

    Content type: Research

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  27. Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity....

    Authors: J. C. L. Alfonso and L. Berk

    Citation: Radiation Oncology 2019 14:88

    Content type: Research

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  28. Intrafraction motion is particularly problematic in case of small target volumes and narrow margins. Here we simulate the dose coverage of intraprostatic lesions (IPL) by simultaneous integrated boosts (SIB). ...

    Authors: Hendrik Ballhausen, Minglun Li, Michael Reiner and Claus Belka

    Citation: Radiation Oncology 2019 14:81

    Content type: Research

    Published on:

    The Data Descriptor to this article has been published in Scientific Data 2019 6:269

  29. For radiotherapy of abdominal cancer, four-dimensional magnetic resonance imaging (4DMRI) is desirable for tumor definition and the assessment of tumor and organ motion. However, irregular breathing gives rise...

    Authors: Z. van Kesteren, A. van der Horst, O. J. Gurney-Champion, I. Bones, D. Tekelenburg, T. Alderliesten, G. van Tienhoven, R. Klaassen, H. W. M. van Laarhoven and A. Bel

    Citation: Radiation Oncology 2019 14:80

    Content type: Research

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  30. To reduce radiation doses to the tongue, a patient-specific semi-customized tongue displacement device (SCTDD) was developed using a 3D printer (3DP) for head and neck (H&N) radiation therapy (RT). Dosimetric ...

    Authors: Chae-Seon Hong, Dongryul Oh, Sang Gyu Ju, Yong Chan Ahn, Cho Hee Na, Dong Yeol Kwon and Cheol Chong Kim

    Citation: Radiation Oncology 2019 14:79

    Content type: Research

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  31. Commissioning of treatment planning systems (TPS) and beam delivery for scanned light ion beams is an important quality assurance task. This requires measurement of large sets of high quality dosimetric data i...

    Authors: O. Jäkel, B. Ackermann, S. Ecker, M. Ellerbrock, P. Heeg, K. Henkner and M. Winter

    Citation: Radiation Oncology 2019 14:77

    Content type: Methodology

    Published on:

  32. The radiation transmission through the multileaf collimators is undesired in modern techniques such as volumetric modulated arc therapy (VMAT). According to identical plans, in this study, we aim to investigat...

    Authors: Kai Xie, Hongfei Sun, Liugang Gao, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2019 14:75

    Content type: Research

    Published on:

  33. In this study, an external 8 mm thick aluminum target was installed on the upper accessory tray mount of a medical linear accelerator head. The purpose of this study was to determine the effects of the externa...

    Authors: Jonggeun Baek, Hyungdong Kim, Byungyong Kim, Youngkee Oh and Hyunsoo Jang

    Citation: Radiation Oncology 2019 14:70

    Content type: Research

    Published on:

  34. To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator.

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Tomohiro Ono, Hiraku Iramina and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:62

    Content type: Research

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  35. We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.

    Authors: Yeona Cho, Yoon Jin Cho, Won Suk Chang, Jun Won Kim, Won Hoon Choi and Ik Jae Lee

    Citation: Radiation Oncology 2019 14:56

    Content type: Research

    Published on:

  36. To perform a dosimetric evaluation of four different simultaneous integrated boost whole brain radiotherapy modalities with hippocampus and inner ear avoidance in the treatment of limited brain metastases.

    Authors: Aijun Jiang, Weipeng Sun, Fen Zhao, Zhenxuan Wu, Dongping Shang, Qingxi Yu, Suzhen Wang, Jian Zhu, Fengchang Yang and Shuanghu Yuan

    Citation: Radiation Oncology 2019 14:46

    Content type: Research

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  37. To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

    Authors: Jiazhou Wang, Yibing Miao, Xiaomin Ou, Xiaoshen Wang, Xiayun He, Chunying Shen, Hongmei Ying, Weigang Hu and Chaosu Hu

    Citation: Radiation Oncology 2019 14:42

    Content type: Research

    Published on:

  38. Measurement-guided dose reconstruction has lately attracted significant attention because it can predict the delivered patient dose distribution. Although the treatment planning system (TPS) uses sophisticated...

    Authors: Akari Kaneko, Iori Sumida, Hirokazu Mizuno, Fumiaki Isohashi, Osamu Suzuki, Yuji Seo, Keisuke Otani, Keisuke Tamari and Kazuhiko Ogawa

    Citation: Radiation Oncology 2019 14:36

    Content type: Research

    Published on:

  39. Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay e...

    Authors: Kai Dolde, Ye Zhang, Naved Chaudhri, Christian Dávid, Marc Kachelrieß, Antony John Lomax, Patrick Naumann, Nami Saito, Damien Charles Weber and Asja Pfaffenberger

    Citation: Radiation Oncology 2019 14:30

    Content type: Research

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  40. The purpose of this study was to compare automatically generated VMAT plans to find the superior beam configurations for Pinnacle3 Auto-Planning and share “best practices”.

    Authors: Anne Richter, Florian Exner, Klaus Bratengeier, Bülent Polat, Michael Flentje and Stefan Weick

    Citation: Radiation Oncology 2019 14:12

    Content type: Research

    Published on:

  41. Due to the heterogeneity of patient’s individual respiratory motion pattern in lung stereotactic body radiotherapy (SBRT), treatment planning dose assessment using a traditional four-dimensional computed tomog...

    Authors: Gang Liu, Fala Hu, Xuanfeng Ding, Xiaoqiang Li, Qihong Shao, Yuenan Wang, Jing Yang and Hong Quan

    Citation: Radiation Oncology 2019 14:1

    Content type: Research

    Published on:

  42. PRIMO is a dose verification system based on the general-purpose Monte Carlo radiation transport code penelope, which implements an accurate physics model of the interaction cross sections and the radiation trans...

    Authors: Miguel Rodriguez, Josep Sempau, Christian Bäumer, Beate Timmermann and Lorenzo Brualla

    Citation: Radiation Oncology 2018 13:256

    Content type: Research

    Published on:

  43. Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, ...

    Authors: Verónica García-Vázquez, Begoña Sesé-Lucio, Felipe A. Calvo, Juan J. Vaquero, Manuel Desco and Javier Pascau

    Citation: Radiation Oncology 2018 13:243

    Content type: Research

    Published on:

  44. Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers...

    Authors: Marc Ziegler, Tobias Brandt, Sebastian Lettmaier, Rainer Fietkau and Christoph Bert

    Citation: Radiation Oncology 2018 13:242

    Content type: Research

    Published on:

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