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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. Hypofractionated whole-breast irradiation is a standard adjuvant therapy for early-stage breast cancer. This study evaluates the plan quality and efficacy of an in-house-developed automated radiotherapy treatm...

    Authors: Ting-Chun Lin, Chih-Yuan Lin, Kai-Chiun Li, Jin-Huei Ji, Ji-An Liang, An-Cheng Shiau, Liang-Chih Liu and Ti-Hao Wang

    Citation: Radiation Oncology 2020 15:67

    Content type: Research

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  2. This work aims at clinically validating a graphical tool developed for treatment plan assessment, named SPIDERplan, by comparing the plan choices based on its scoring with the radiation oncologists (RO) clinic...

    Authors: Tiago Ventura, Joana Dias, Leila Khouri, Eduardo Netto, André Soares, Brigida da Costa Ferreira, Humberto Rocha and Maria do Carmo Lopes

    Citation: Radiation Oncology 2020 15:64

    Content type: Research

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  3. To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protoco...

    Authors: Anna Sophie Duque, Stefanie Corradini, Florian Kamp, Max Seidensticker, Florian Streitparth, Christopher Kurz, Franziska Walter, Katia Parodi, Frank Verhaegen, Jens Ricke, Claus Belka, Gabriel Paiva Fonseca and Guillaume Landry

    Citation: Radiation Oncology 2020 15:60

    Content type: Research

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  4. To quantify tumor anatomic change of non-small cell lung cancer (NSCLC) patients given passive-scattering proton therapy (PSPT) and intensity-modulated radiation therapy (IMRT) through 6–7 weeks of treatment, ...

    Authors: Mei Chen, Jinzhong Yang, Zhongxing Liao, Jiayi Chen, Cheng Xu, Xiaodong He, Xiaodong Zhang, Ronald X. Zhu and Heng Li

    Citation: Radiation Oncology 2020 15:55

    Content type: Research

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  5. The internal target volume (ITV) approach and the mid-ventilation (MidV) concept are the two main respiratory motion-management strategies under free breathing. The purpose of this work was to compare the actu...

    Authors: J. Bellec, F. Arab-Ceschia, J. Castelli, C. Lafond and E. Chajon

    Citation: Radiation Oncology 2020 15:54

    Content type: Research

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  6. Although whole brain radiation therapy (WBRT) provides palliation and prophylaxis, reduces local recurrence probability and improves overall survival, it is evident that WBRT is associated with neurocognitive ...

    Authors: Adams Hei Long Yuen, Po Man Wu, Alex Kai Leung Li and Philip Chung Yin Mak

    Citation: Radiation Oncology 2020 15:42

    Content type: Research

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  7. The STAR-TReC trial is an international multi-center, randomized, phase II study assessing the feasibility of short-course radiotherapy or long-course chemoradiotherapy as an alternative to total mesorectal ex...

    Authors: Roy P. J. van den Ende, Femke P. Peters, Ernst Harderwijk, Heidi Rütten, Liza Bouwmans, Maaike Berbee, Richard A. M. Canters, Georgiana Stoian, Kim Compagner, Tom Rozema, Mariska de Smet, Martijn P. W. Intven, Rob H. N. Tijssen, Jacqueline Theuws, Paul van Haaren, Baukelien van Triest…

    Citation: Radiation Oncology 2020 15:41

    Content type: Research

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  8. To ascertain the dosimetric performance of a new delivery system (the Halcyon system, H) equipped with dual-layer stacked multi-leaf collimator (MLC) for risk-adapted targets in cervix uteri cancer patients co...

    Authors: S. Panda, J. Swamidas, S. Chopra, A. Mangaj, A. Fogliata, P. Kupelian, J. P. Agarwal and L. Cozzi

    Citation: Radiation Oncology 2020 15:22

    Content type: Research

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  9. To explore the dosimetric improvement, delivery efficiency, and plan robustness for bilateral head and neck cancer (HNC) treatment utilizing a novel proton therapy technique – the spot-scanning proton arc (SPA...

    Authors: Gang Liu, Xiaoqiang Li, An Qin, Weili Zheng, Di Yan, Sheng Zhang, Craig Stevens, Peyman Kabolizadeh and Xuanfeng Ding

    Citation: Radiation Oncology 2020 15:21

    Content type: Research

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  10. To compare target coverage and dose to the organs at risk in two approaches to rectal cancer: a clinically implemented adaptive radiotherapy (ART) strategy using plan selection, and a non-adaptive (non-ART) st...

    Authors: R. de Jong, J. Visser, K. F. Crama, N. van Wieringen, J. Wiersma, E. D. Geijsen and A. Bel

    Citation: Radiation Oncology 2020 15:13

    Content type: Research

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  11. To investigate the role of intensity modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for advanced supradiaphragmatic Hodgkin’s lymphoma (HL) in young female patients by asse...

    Authors: Marta Scorsetti, Luca Cozzi, Pierina Navarria, Antonella Fogliata, Alexia Rossi, Davide Franceschini, Fiorenza De Rose, Ciro Franzese, Carmelo Carlo-Stella and Armando Santoro

    Citation: Radiation Oncology 2020 15:12

    Content type: Research

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  12. Intra-and inter-tumoral heterogeneity in growth dynamics and vascularity influence tumor response to radiation therapy. Quantitative imaging techniques capture these dynamics non-invasively, and these data can...

    Authors: David A. Hormuth II, Angela M. Jarrett and Thomas E. Yankeelov

    Citation: Radiation Oncology 2020 15:4

    Content type: Research

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  13. Cardiac activity could impact the accuracy of dose assessment for the heart, pericardium and left ventricular myocardium (LVM). The purpose of this study was to explore whether it is possible to perform dose a...

    Authors: Ying Tong, Guanzhong Gong, Ming Su and Yong Yin

    Citation: Radiation Oncology 2019 14:242

    Content type: Research

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  14. Helical tomotherapy has been applied to total marrow irradiation (HT-TMI). Our objective was to apply failure mode and effects analysis (FMEA) two times separated by 1 year to evaluate and improve the safety o...

    Authors: Jiuling Shen, Xiaoyong Wang, Di Deng, Jian Gong, Kang Tan, Hongli Zhao, Zhirong Bao, Jinping Xiao, An Liu, Yunfeng Zhou, Hui Liu and Conghua Xie

    Citation: Radiation Oncology 2019 14:238

    Content type: Research

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  15. In this study, a novel pelvic phantom was developed and used to assess the visibility and presence of artefacts from different types of commercial fiducial markers (FMs) on multi-modality imaging relevant to p...

    Authors: Sarah O. S. Osman, Emily Russell, Raymond B. King, Karen Crowther, Suneil Jain, Cormac McGrath, Alan R. Hounsell, Kevin M. Prise and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:237

    Content type: Research

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  16. Tomotherapy-based total body irradiation (TBI) is performed using the head-first position (HFP) and feet-first position (FFP) due to treatment length exceeding the 135 cm limit. To reduce the dosimetric variat...

    Authors: Chae-Seon Hong, Min-Joo Kim, Jihun Kim, Kyung Hwan Chang, Kwangwoo Park, Dong Wook Kim, Min Cheol Han, Hong In Yoon, Jin Sung Kim and Ho Lee

    Citation: Radiation Oncology 2019 14:233

    Content type: Research

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  17. To develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency a...

    Authors: Xiao Wang, Chi Ma, Rihan Davis, Rahul R. Parikh, Salma K. Jabbour, Bruce G. Haffty, Ning J. Yue, Ke Nie and Yin Zhang

    Citation: Radiation Oncology 2019 14:224

    Content type: Research

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  18. In order to locate an arteriovenous malformation, typically, a digital subtraction angiography (DSA) is carried out. To use the DSA for target definition an accurate image registration between CT and DSA is re...

    Authors: Daniel Schmidhalter, Dominik Henzen, Evelyn Herrmann, Werner Volken, Paul-Henry Mackeprang, Ekin Ermis, Hossein Hemmatazad, Jonas Honegger, Benjamin Haas, Michael K. Fix and Peter Manser

    Citation: Radiation Oncology 2019 14:217

    Content type: Research

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  19. PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characte...

    Authors: Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti and Stefano Tomatis

    Citation: Radiation Oncology 2019 14:216

    Content type: Research

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  20. The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spa...

    Authors: Masayoshi Yamada, Hiraku Sato, Yoshiro Ieko, Yuya Miyasaka, Takayuki Kanai, Natsuko Yano, Takashi Ono, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Yasushi Teranishi, Yasuhiro Kikuchi and Kenji Nemoto

    Citation: Radiation Oncology 2019 14:207

    Content type: Research

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  21. Stereotactic body radiation therapy (SBRT) was found effective in treating laryngeal cancer with only five treatment fractions by a recent clinical trial (NCT01984502, ClinicalTrials.gov). Nevertheless, this t...

    Authors: You Zhang, Tsuicheng Chiu, Jeffrey Dubas, Zhen Tian, Pam Lee, Xuejun Gu, Yulong Yan, David Sher, Robert Timmerman and Bo Zhao

    Citation: Radiation Oncology 2019 14:193

    Content type: Research

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  22. Patients treated with radiotherapy for head and neck (H&N) cancer often experience anatomical changes. The potential compromises to Planning Target Volume (PTV) coverage or Organ at Risk (OAR) sparing has prom...

    Authors: Louise Belshaw, Christina E. Agnew, Denise M. Irvine, Keith P. Rooney and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:189

    Content type: Research

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  23. To determine if the performance of a knowledge based RapidPlan (RP) planning model could be improved with an iterative learning process, i.e. if plans generated by an RP model could be used as new input to re-...

    Authors: A. Fogliata, L. Cozzi, G. Reggiori, A. Stravato, F. Lobefalo, C. Franzese, D. Franceschini, S. Tomatis and M. Scorsetti

    Citation: Radiation Oncology 2019 14:187

    Content type: Research

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  24. To quantify the effects of the Bragg peak degradation due to lung tissue on treatment plans of lung cancer patients with spot scanning proton therapy and to give a conservative approximation of these effects.

    Authors: Kilian-Simon Baumann, Veronika Flatten, Uli Weber, Stefan Lautenschläger, Fabian Eberle, Klemens Zink and Rita Engenhart-Cabillic

    Citation: Radiation Oncology 2019 14:183

    Content type: Research

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    The Correction to this article has been published in Radiation Oncology 2020 15:29

  25. Vendor-independent Monte Carlo (MC) dose calculation (IDC) for patient-specific quality assurance of multi-leaf collimator (MLC) based CyberKnife treatments is used to benchmark and validate the commercial MC ...

    Authors: P.-H. Mackeprang, D. Vuong, W. Volken, D. Henzen, D. Schmidhalter, M. Malthaner, S. Mueller, D. Frei, W. Kilby, D. M. Aebersold, M. K. Fix and P. Manser

    Citation: Radiation Oncology 2019 14:172

    Content type: Research

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  26. To provide fast and accurate dose calculation in voxelized geometries for proton radiation therapy by implementing an adaptive step size algorithm in the proton macro Monte Carlo (pMMC) method.

    Authors: Reto Kueng, Daniel Frei, Werner Volken, Fabian Stuermlin, Marco F. M. Stampanoni, Daniel M. Aebersold, Peter Manser and Michael K. Fix

    Citation: Radiation Oncology 2019 14:165

    Content type: Research

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  27. The treatment of lung lesions with stereotactic body radiation therapy calls for highly conformal dose, which is evaluated by a number of metrics. Lung stereotactic body radiation therapy clinical trials const...

    Authors: David Hoffman, Irena Dragojević, Jeremy Hoisak, David Hoopes and Ryan Manger

    Citation: Radiation Oncology 2019 14:162

    Content type: Research

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  28. Target localization in radiation therapy is affected by numerous sources of uncertainty. Despite measures to minimize the breathing motion, the treatment of hypofractionated liver radiation therapy is further ...

    Authors: Gye Won Choi, Yelin Suh, Prajnan Das, Joseph Herman, Emma Holliday, Eugene Koay, Albert C. Koong, Sunil Krishnan, Bruce D. Minsky, Grace L. Smith, Cullen M. Taniguchi and Sam Beddar

    Citation: Radiation Oncology 2019 14:154

    Content type: Research

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  29. Heterogeneous target doses are a common by-product from attempts to improve normal tissue sparing in radiosurgery treatment planning. These regions of escalated dose within the target may increase tumor contro...

    Authors: William T. Hrinivich, Todd R. McNutt and Jeffrey J. Meyer

    Citation: Radiation Oncology 2019 14:145

    Content type: Research

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  30. This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system.

    Authors: Jung-in Kim, Jong Min Park, Chang Heon Choi, Hyun Joon An, Yi-Jun Kim and Jin Ho Kim

    Citation: Radiation Oncology 2019 14:139

    Content type: Research

    Published on:

  31. To quantify the dosimetric parameters of different bone marrow sparing strategies and to determine the optimal strategy for cervical cancer patients undergoing postoperative intensity-modulated radiotherapy (I...

    Authors: Zhirong Bao, Dajiang Wang, Shupeng Chen, Min Chen, Dazhen Jiang, Chunxu Yang, Hui Liu, Jing Dai and Conghua Xie

    Citation: Radiation Oncology 2019 14:118

    Content type: Research

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  32. Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby

    Citation: Radiation Oncology 2019 14:134

    Content type: Review

    Published on:

  33. The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita

    Citation: Radiation Oncology 2019 14:133

    Content type: Research

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  34. To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee

    Citation: Radiation Oncology 2019 14:131

    Content type: Research

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  35. To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang

    Citation: Radiation Oncology 2019 14:129

    Content type: Research

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  36. Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study pres...

    Authors: J. Visser, P. de Boer, K. F. Crama, Z. van Kesteren, C. R. N. Rasch, L. J. A. Stalpers and A. Bel

    Citation: Radiation Oncology 2019 14:126

    Content type: Research

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  37. To determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Secondly, to evaluat...

    Authors: Vincent C. Hamming, Christa Visser, Estelle Batin, Leah N. McDermott, Dianne M. Busz, Stefan Both, Johannes A. Langendijk and Nanna M. Sijtsema

    Citation: Radiation Oncology 2019 14:125

    Content type: Research

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  38. Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated t...

    Authors: Stewart Mein, Ivana Dokic, Carmen Klein, Thomas Tessonnier, Till Tobias Böhlen, Guiseppe Magro, Julia Bauer, Alfredo Ferrari, Katia Parodi, Thomas Haberer, Jürgen Debus, Amir Abdollahi and Andrea Mairani

    Citation: Radiation Oncology 2019 14:123

    Content type: Research

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  39. To calculate the individualized fraction regime (IFR) in stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) patients using the uncomplicated tumor control probability (UTCP, P+) function...

    Authors: Jia-Yang Lu, Pei-Xian Lin and Bao-Tian Huang

    Citation: Radiation Oncology 2019 14:111

    Content type: Research

    Published on:

  40. The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues

    Citation: Radiation Oncology 2019 14:108

    Content type: Methodology

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  41. In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2019 14:103

    Content type: Research

    Published on:

  42. Liver tumors are subject to motion with respiration, which is typically accounted for by increasing the target volume. The prescription dose is often reduced to keep the mean liver dose under a threshold level...

    Authors: M. Gargett, C. Haddad, A. Kneebone, J. T. Booth and N. Hardcastle

    Citation: Radiation Oncology 2019 14:93

    Content type: Research

    Published on:

  43. Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity....

    Authors: J. C. L. Alfonso and L. Berk

    Citation: Radiation Oncology 2019 14:88

    Content type: Research

    Published on:

  44. Intrafraction motion is particularly problematic in case of small target volumes and narrow margins. Here we simulate the dose coverage of intraprostatic lesions (IPL) by simultaneous integrated boosts (SIB). ...

    Authors: Hendrik Ballhausen, Minglun Li, Michael Reiner and Claus Belka

    Citation: Radiation Oncology 2019 14:81

    Content type: Research

    Published on:

    The Data Descriptor to this article has been published in Scientific Data 2019 6:269

  45. To reduce radiation doses to the tongue, a patient-specific semi-customized tongue displacement device (SCTDD) was developed using a 3D printer (3DP) for head and neck (H&N) radiation therapy (RT). Dosimetric ...

    Authors: Chae-Seon Hong, Dongryul Oh, Sang Gyu Ju, Yong Chan Ahn, Cho Hee Na, Dong Yeol Kwon and Cheol Chong Kim

    Citation: Radiation Oncology 2019 14:79

    Content type: Research

    Published on:

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