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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. In this study, we employed a gated recurrent unit (GRU)-based recurrent neural network (RNN) using dosimetric information induced by individual beam to predict the dose-volume histogram (DVH) and investigated ...

    Authors: Wufei Cao, Yongdong Zhuang, Lixin Chen and Xiaowei Liu

    Citation: Radiation Oncology 2020 15:216

    Content type: Research

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  2. Online adaptive radiotherapy is intended to prevent plan degradation caused by inter-fractional tumor volume and shape changes, but time limitations make online re-planning challenging. The aim of this study w...

    Authors: Janita E. van Timmeren, Madalyne Chamberlain, Jérôme Krayenbuehl, Lotte Wilke, Stefanie Ehrbar, Marta Bogowicz, Callum Hartley, Mariangela Zamburlini, Nicolaus Andratschke, Helena Garcia Schüler, Matea Pavic, Panagiotis Balermpas, Chaehee Ryu, Matthias Guckenberger and Stephanie Tanadini-Lang

    Citation: Radiation Oncology 2020 15:203

    Content type: Research

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  3. To investigate the feasibility of a knowledge-based automated intensity-modulated radiation therapy (IMRT) planning technique for locally advanced nasopharyngeal carcinoma (NPC) radiotherapy.

    Authors: Penggang Bai, Xing Weng, Kerun Quan, Jihong Chen, Yitao Dai, Yuanji Xu, Fasheng Lin, Jing Zhong, Tianming Wu and Chuanben Chen

    Citation: Radiation Oncology 2020 15:188

    Content type: Research

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  4. The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. Although t...

    Authors: P. Freislederer, M. Kügele, M. Öllers, A. Swinnen, T.-O. Sauer, C. Bert, D. Giantsoudi, S. Corradini and V. Batista

    Citation: Radiation Oncology 2020 15:187

    Content type: Review

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  5. Automatic tumor segmentation based on Convolutional Neural Networks (CNNs) has shown to be a valuable tool in treatment planning and clinical decision making. We investigate the influence of 7 MRI input channe...

    Authors: Lars Bielak, Nicole Wiedenmann, Arnie Berlin, Nils Henrik Nicolay, Deepa Darshini Gunashekar, Leonard Hägele, Thomas Lottner, Anca-Ligia Grosu and Michael Bock

    Citation: Radiation Oncology 2020 15:181

    Content type: Research

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  6. Impaired function of masticatory muscles will lead to trismus. Routine delineation of these muscles during planning may improve dose tracking and facilitate dose reduction resulting in decreased radiation-rela...

    Authors: Wen Chen, Yimin Li, Brandon A. Dyer, Xue Feng, Shyam Rao, Stanley H. Benedict, Quan Chen and Yi Rong

    Citation: Radiation Oncology 2020 15:176

    Content type: Research

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  7. Total scalp irradiation presents technical and dosimetric challenges. While reports suggest that HyperArc, a new stereotactic radiosurgery planning technique applied to non-coplanar volumetric-modulated arc th...

    Authors: Shoki Inui, Yoshihiro Ueda, Shingo Ohira, Haruhi Tsuru, Masaru Isono, Masayoshi Miyazaki, Masahiko Koizumi and Teruki Teshima

    Citation: Radiation Oncology 2020 15:175

    Content type: Research

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  8. This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework include...

    Authors: E. J. Her, A. Haworth, H. M. Reynolds, Y. Sun, A. Kennedy, V. Panettieri, M. Bangert, S. Williams and M. A. Ebert

    Citation: Radiation Oncology 2020 15:172

    Content type: Research

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  9. Surface-guided radiation therapy (SGRT) employs a non-invasive real-time optical surface imaging (OSI) technique for patient surface motion monitoring during radiotherapy. The main purpose of this study is to ...

    Authors: Li Chen, Sen Bai, Guangjun Li, Zhibin Li, Qing Xiao, Long Bai, Changhu Li, Lixun Xian, Zhenyao Hu, Guyu Dai and Guangyu Wang

    Citation: Radiation Oncology 2020 15:170

    Content type: Research

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  10. Many dose calculation algorithms for radiotherapy planning need to be configured for each clinical beam using pre-defined measurements. An optimization process adjusts the physical parameters able to estimate ...

    Authors: A. Fogliata, E. Esposito, L. Paganini, G. Reggiori, S. Tomatis, M. Scorsetti and L. Cozzi

    Citation: Radiation Oncology 2020 15:169

    Content type: Research

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  11. The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (M...

    Authors: Annika Mannerberg, Emilia Persson, Joakim Jonsson, Christian Jamtheim Gustafsson, Adalsteinn Gunnlaugsson, Lars E. Olsson and Sofie Ceberg

    Citation: Radiation Oncology 2020 15:168

    Content type: Research

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  12. To evaluate dosimetric differences of salvage irradiations using two commercially available volumetric modulated arc therapy (VMAT) stereotactic body radiation therapy (SBRT) techniques: RapidArc (RA) and Hype...

    Authors: Hsiu-Wen Ho, Steve P. Lee, Hisu-Man Lin, Hsiao-Yun Chen, Chun-Chiao Huang, Shih-Chang Wang, Ching-Chieh Yang and Yu-Wei Lin

    Citation: Radiation Oncology 2020 15:164

    Content type: Research

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  13. To explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).

    Authors: Han Bai, Sijin Zhu, Xingrao Wu, Xuhong Liu, Feihu Chen and Jiawen Yan

    Citation: Radiation Oncology 2020 15:161

    Content type: Research

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  14. Healthcare workers occupationally exposed to 18F-FDG cannot wear protective equipment, such as lead aprons, since the interaction between high energy radiation (511 keV) and metal increases the dose of radiation ...

    Authors: Nilson Benedito Lopes, Igor Vivian Almeida, Pedro Henrique Silvestre Lopes and Veronica Elisa Pimenta Vicentini

    Citation: Radiation Oncology 2020 15:154

    Content type: Research

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  15. Optimal alignment is of utmost importance when treating pediatric patients with craniospinal irradiation (CSI), especially with regards to field junctions and multiple isocenters and techniques applying high d...

    Authors: Daniel Gram, André Haraldsson, N. Patrik Brodin, Karsten Nysom, Thomas Björk-Eriksson and Per Munck af Rosenschöld

    Citation: Radiation Oncology 2020 15:149

    Content type: Research

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  16. PTV concept is presumed to introduce excessive and inconsistent GTV dose in lung stereotactic body radiotherapy (SBRT). That GTV median dose prescription (D50) and robust optimization are viable PTV–free solution...

    Authors: Ronnie Wing King Leung, Mark Ka Heng Chan, Chi-Leung Chiang, Matthew Wong and Oliver Blanck

    Citation: Radiation Oncology 2020 15:130

    Content type: Research

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  17. The targeting accuracy of proton therapy (PT) for moving soft-tissue tumours is expected to greatly improve by real-time magnetic resonance imaging (MRI) guidance. The integration of MRI and PT at the treatmen...

    Authors: Aswin Hoffmann, Bradley Oborn, Maryam Moteabbed, Susu Yan, Thomas Bortfeld, Antje Knopf, Herman Fuchs, Dietmar Georg, Joao Seco, Maria Francesca Spadea, Oliver Jäkel, Christopher Kurz and Katia Parodi

    Citation: Radiation Oncology 2020 15:129

    Content type: Review

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  18. To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT), realised with RapidArc and RapidPlan methods (RA_RP) for neoadjuvant radiotherapy in lo...

    Authors: Eren Celik, Wolfgang Baus, Christian Baues, Wolfgang Schröder, Alessandro Clivio, Antonella Fogliata, Marta Scorsetti, Simone Marnitz and Luca Cozzi

    Citation: Radiation Oncology 2020 15:120

    Content type: Research

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  19. Photo-neutrons are produced at the head of the medical linear accelerators (linac) by the interaction of high-energy photons, and patients receive a whole-body-absorbed dose from these neutrons. The current st...

    Authors: Younes Afkham, Asghar Mesbahi, Abdolali Alemi, Farhad Zolfagharpour and Nasrollah Jabbari

    Citation: Radiation Oncology 2020 15:105

    Content type: Research

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  20. Volumetric modulated arc therapy (VMAT) adopted in post-mastectomy radiation therapy (PMRT) has the capacity to achieve highly conformal dose distributions. The research aims to evaluate the impact of position...

    Authors: Xiongfei Liao, Fan Wu, Junxiang Wu, Qian Peng, Xinghong Yao, Shengwei Kang, Yanqun Zhao and Lucia Clara Orlandini

    Citation: Radiation Oncology 2020 15:103

    Content type: Research

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  21. Automated brain tumor segmentation methods are computational algorithms that yield tumor delineation from, in this case, multimodal magnetic resonance imaging (MRI). We present an automated segmentation method...

    Authors: Ekin Ermiş, Alain Jungo, Robert Poel, Marcela Blatti-Moreno, Raphael Meier, Urspeter Knecht, Daniel M. Aebersold, Michael K. Fix, Peter Manser, Mauricio Reyes and Evelyn Herrmann

    Citation: Radiation Oncology 2020 15:100

    Content type: Research

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  22. The integration of magnetic resonance imaging (MRI) for guidance in external beam radiotherapy has faced significant research and development efforts in recent years. The current availability of linear acceler...

    Authors: Christopher Kurz, Giulia Buizza, Guillaume Landry, Florian Kamp, Moritz Rabe, Chiara Paganelli, Guido Baroni, Michael Reiner, Paul J. Keall, Cornelis A. T. van den Berg and Marco Riboldi

    Citation: Radiation Oncology 2020 15:93

    Content type: Review

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  23. In most clinical trials, gold fiducial markers are implanted in the prostate to tune the table position before each radiation beam. Yet, it is unclear if a cone-beam computed tomography (CBCT) should be perfor...

    Authors: Omar Jmour, Marouan Benna, Pierre Champagnol, Majed Ben Mrad, Anis Hamrouni, Layal Obeid, Chaimaa Lahmamssi, Amal Bousarsar, Nicolas Vial, Amel Rehailia-Blanchard, Sandrine Sotton, Meiling Lan, Julien Langrand-Escure, Alexis Vallard and Nicolas Magné

    Citation: Radiation Oncology 2020 15:85

    Content type: Short report

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  24. Retrospective studies on MRI-only radiotherapy have been presented. Widespread clinical implementations of MRI-only workflows are however limited by the absence of guidelines. The MR-PROTECT trial presents an ...

    Authors: Emilia Persson, Christian Jamtheim Gustafsson, Petra Ambolt, Silke Engelholm, Sofie Ceberg, Sven Bäck, Lars E. Olsson and Adalsteinn Gunnlaugsson

    Citation: Radiation Oncology 2020 15:77

    Content type: Research

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  25. Hypofractionated whole-breast irradiation is a standard adjuvant therapy for early-stage breast cancer. This study evaluates the plan quality and efficacy of an in-house-developed automated radiotherapy treatm...

    Authors: Ting-Chun Lin, Chih-Yuan Lin, Kai-Chiun Li, Jin-Huei Ji, Ji-An Liang, An-Cheng Shiau, Liang-Chih Liu and Ti-Hao Wang

    Citation: Radiation Oncology 2020 15:67

    Content type: Research

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  26. This work aims at clinically validating a graphical tool developed for treatment plan assessment, named SPIDERplan, by comparing the plan choices based on its scoring with the radiation oncologists (RO) clinic...

    Authors: Tiago Ventura, Joana Dias, Leila Khouri, Eduardo Netto, André Soares, Brigida da Costa Ferreira, Humberto Rocha and Maria do Carmo Lopes

    Citation: Radiation Oncology 2020 15:64

    Content type: Research

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  27. To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protoco...

    Authors: Anna Sophie Duque, Stefanie Corradini, Florian Kamp, Max Seidensticker, Florian Streitparth, Christopher Kurz, Franziska Walter, Katia Parodi, Frank Verhaegen, Jens Ricke, Claus Belka, Gabriel Paiva Fonseca and Guillaume Landry

    Citation: Radiation Oncology 2020 15:60

    Content type: Research

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  28. To quantify tumor anatomic change of non-small cell lung cancer (NSCLC) patients given passive-scattering proton therapy (PSPT) and intensity-modulated radiation therapy (IMRT) through 6–7 weeks of treatment, ...

    Authors: Mei Chen, Jinzhong Yang, Zhongxing Liao, Jiayi Chen, Cheng Xu, Xiaodong He, Xiaodong Zhang, Ronald X. Zhu and Heng Li

    Citation: Radiation Oncology 2020 15:55

    Content type: Research

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  29. The internal target volume (ITV) approach and the mid-ventilation (MidV) concept are the two main respiratory motion-management strategies under free breathing. The purpose of this work was to compare the actu...

    Authors: J. Bellec, F. Arab-Ceschia, J. Castelli, C. Lafond and E. Chajon

    Citation: Radiation Oncology 2020 15:54

    Content type: Research

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  30. Although whole brain radiation therapy (WBRT) provides palliation and prophylaxis, reduces local recurrence probability and improves overall survival, it is evident that WBRT is associated with neurocognitive ...

    Authors: Adams Hei Long Yuen, Po Man Wu, Alex Kai Leung Li and Philip Chung Yin Mak

    Citation: Radiation Oncology 2020 15:42

    Content type: Research

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  31. The STAR-TReC trial is an international multi-center, randomized, phase II study assessing the feasibility of short-course radiotherapy or long-course chemoradiotherapy as an alternative to total mesorectal ex...

    Authors: Roy P. J. van den Ende, Femke P. Peters, Ernst Harderwijk, Heidi Rütten, Liza Bouwmans, Maaike Berbee, Richard A. M. Canters, Georgiana Stoian, Kim Compagner, Tom Rozema, Mariska de Smet, Martijn P. W. Intven, Rob H. N. Tijssen, Jacqueline Theuws, Paul van Haaren, Baukelien van Triest…

    Citation: Radiation Oncology 2020 15:41

    Content type: Research

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  32. To ascertain the dosimetric performance of a new delivery system (the Halcyon system, H) equipped with dual-layer stacked multi-leaf collimator (MLC) for risk-adapted targets in cervix uteri cancer patients co...

    Authors: S. Panda, J. Swamidas, S. Chopra, A. Mangaj, A. Fogliata, P. Kupelian, J. P. Agarwal and L. Cozzi

    Citation: Radiation Oncology 2020 15:22

    Content type: Research

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  33. To explore the dosimetric improvement, delivery efficiency, and plan robustness for bilateral head and neck cancer (HNC) treatment utilizing a novel proton therapy technique – the spot-scanning proton arc (SPA...

    Authors: Gang Liu, Xiaoqiang Li, An Qin, Weili Zheng, Di Yan, Sheng Zhang, Craig Stevens, Peyman Kabolizadeh and Xuanfeng Ding

    Citation: Radiation Oncology 2020 15:21

    Content type: Research

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  34. To compare target coverage and dose to the organs at risk in two approaches to rectal cancer: a clinically implemented adaptive radiotherapy (ART) strategy using plan selection, and a non-adaptive (non-ART) st...

    Authors: R. de Jong, J. Visser, K. F. Crama, N. van Wieringen, J. Wiersma, E. D. Geijsen and A. Bel

    Citation: Radiation Oncology 2020 15:13

    Content type: Research

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  35. To investigate the role of intensity modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT) for advanced supradiaphragmatic Hodgkin’s lymphoma (HL) in young female patients by asse...

    Authors: Marta Scorsetti, Luca Cozzi, Pierina Navarria, Antonella Fogliata, Alexia Rossi, Davide Franceschini, Fiorenza De Rose, Ciro Franzese, Carmelo Carlo-Stella and Armando Santoro

    Citation: Radiation Oncology 2020 15:12

    Content type: Research

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  36. Intra-and inter-tumoral heterogeneity in growth dynamics and vascularity influence tumor response to radiation therapy. Quantitative imaging techniques capture these dynamics non-invasively, and these data can...

    Authors: David A. Hormuth II, Angela M. Jarrett and Thomas E. Yankeelov

    Citation: Radiation Oncology 2020 15:4

    Content type: Research

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  37. Cardiac activity could impact the accuracy of dose assessment for the heart, pericardium and left ventricular myocardium (LVM). The purpose of this study was to explore whether it is possible to perform dose a...

    Authors: Ying Tong, Guanzhong Gong, Ming Su and Yong Yin

    Citation: Radiation Oncology 2019 14:242

    Content type: Research

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  38. Helical tomotherapy has been applied to total marrow irradiation (HT-TMI). Our objective was to apply failure mode and effects analysis (FMEA) two times separated by 1 year to evaluate and improve the safety o...

    Authors: Jiuling Shen, Xiaoyong Wang, Di Deng, Jian Gong, Kang Tan, Hongli Zhao, Zhirong Bao, Jinping Xiao, An Liu, Yunfeng Zhou, Hui Liu and Conghua Xie

    Citation: Radiation Oncology 2019 14:238

    Content type: Research

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  39. In this study, a novel pelvic phantom was developed and used to assess the visibility and presence of artefacts from different types of commercial fiducial markers (FMs) on multi-modality imaging relevant to p...

    Authors: Sarah O. S. Osman, Emily Russell, Raymond B. King, Karen Crowther, Suneil Jain, Cormac McGrath, Alan R. Hounsell, Kevin M. Prise and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:237

    Content type: Research

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  40. Tomotherapy-based total body irradiation (TBI) is performed using the head-first position (HFP) and feet-first position (FFP) due to treatment length exceeding the 135 cm limit. To reduce the dosimetric variat...

    Authors: Chae-Seon Hong, Min-Joo Kim, Jihun Kim, Kyung Hwan Chang, Kwangwoo Park, Dong Wook Kim, Min Cheol Han, Hong In Yoon, Jin Sung Kim and Ho Lee

    Citation: Radiation Oncology 2019 14:233

    Content type: Research

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  41. To develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency a...

    Authors: Xiao Wang, Chi Ma, Rihan Davis, Rahul R. Parikh, Salma K. Jabbour, Bruce G. Haffty, Ning J. Yue, Ke Nie and Yin Zhang

    Citation: Radiation Oncology 2019 14:224

    Content type: Research

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  42. In order to locate an arteriovenous malformation, typically, a digital subtraction angiography (DSA) is carried out. To use the DSA for target definition an accurate image registration between CT and DSA is re...

    Authors: Daniel Schmidhalter, Dominik Henzen, Evelyn Herrmann, Werner Volken, Paul-Henry Mackeprang, Ekin Ermis, Hossein Hemmatazad, Jonas Honegger, Benjamin Haas, Michael K. Fix and Peter Manser

    Citation: Radiation Oncology 2019 14:217

    Content type: Research

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  43. PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characte...

    Authors: Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti and Stefano Tomatis

    Citation: Radiation Oncology 2019 14:216

    Content type: Research

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  44. The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spa...

    Authors: Masayoshi Yamada, Hiraku Sato, Yoshiro Ieko, Yuya Miyasaka, Takayuki Kanai, Natsuko Yano, Takashi Ono, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Yasushi Teranishi, Yasuhiro Kikuchi and Kenji Nemoto

    Citation: Radiation Oncology 2019 14:207

    Content type: Research

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  45. Stereotactic body radiation therapy (SBRT) was found effective in treating laryngeal cancer with only five treatment fractions by a recent clinical trial (NCT01984502, ClinicalTrials.gov). Nevertheless, this t...

    Authors: You Zhang, Tsuicheng Chiu, Jeffrey Dubas, Zhen Tian, Pam Lee, Xuejun Gu, Yulong Yan, David Sher, Robert Timmerman and Bo Zhao

    Citation: Radiation Oncology 2019 14:193

    Content type: Research

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