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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. To assess the feasibility of postoperative stereotactic body radiation therapy (SBRT) for patients with hybrid implants consisting of carbon fiber reinforced polyetheretherketone and titanium (CFP-T) using Cyb...

    Authors: Dominik Henzen, Daniel Schmidhalter, Gian Guyer, Anna Stenger-Weisser, Ekin Ermiş, Robert Poel, Moritz Caspar Deml, Michael Karl Fix, Peter Manser, Daniel Matthias Aebersold and Hossein Hemmatazad
    Citation: Radiation Oncology 2022 17:94
  2. Contact lens-type ocular in vivo dosimeters (CLODs) were recently developed as the first in vivo dosimeter that can be worn directly on the eye to measure the dose delivered to the lens during radiotherapy. Ho...

    Authors: Jaeman Son, Jin Dong Cho, Seongmoon Jung, Chang Heon Choi, Jong Min Park and Jung-in Kim
    Citation: Radiation Oncology 2022 17:88
  3. A new compact superconducting synchrocyclotron single-room proton solution delivers pulsed proton beams to each spot through several irradiation bursts calculated by an iterative layer delivery algorithm. Such...

    Authors: Lewei Zhao, Gang Liu, Shupeng Chen, Jiajian Shen, Weili Zheng, An Qin, Di Yan, Xiaoqiang Li and Xuanfeng Ding
    Citation: Radiation Oncology 2022 17:87
  4. This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 meta...

    Authors: Yuan Xu, Yingjie Xu, Kuo Men, Jianping Xiao and Jianrong Dai
    Citation: Radiation Oncology 2022 17:86
  5. Adjuvant radiation therapy improves the overall survival and loco-regional control in patients with breast cancer. However, radiation-induced heart disease, which occurs after treatment from incidental radiati...

    Authors: Jaehee Chun, Jee Suk Chang, Caleb Oh, InKyung Park, Min Seo Choi, Chae-Seon Hong, Hojin Kim, Gowoon Yang, Jin Young Moon, Seung Yeun Chung, Young Joo Suh and Jin Sung Kim
    Citation: Radiation Oncology 2022 17:83
  6. Robotic linac is ideally suited to deliver hypo-fractionated radiotherapy due to its compact head and flexible positioning. The non-coplanar treatment space improves the delivery versatility but the complexity...

    Authors: Bin Liang, Ran Wei, Jianghu Zhang, Yongbao Li, Tao Yang, Shouping Xu, Ke Zhang, Wenlong Xia, Bin Guo, Bo Liu, Fugen Zhou, Qiuwen Wu and Jianrong Dai
    Citation: Radiation Oncology 2022 17:82
  7. The irradiation of breast cancer patients with included internal mammary lymph nodes challenges radiation planning with regard to robustness and protection of OARs. In this publication, a feasible hybrid radia...

    Authors: Marina Hennet, Stephan Radonic, Uwe Schneider and Matthias Hartmann
    Citation: Radiation Oncology 2022 17:76
  8. Four-dimensional cone-beam computed tomography (4D-CBCT) can visualize moving tumors, thus adaptive radiation therapy (ART) could be improved if 4D-CBCT were used. However, 4D-CBCT images suffer from severe im...

    Authors: Keisuke Usui, Koichi Ogawa, Masami Goto, Yasuaki Sakano, Shinsuke Kyougoku and Hiroyuki Daida
    Citation: Radiation Oncology 2022 17:69
  9. To examine the dosimetric feasibility of hypofractionated/dose escalated radiation therapy in patients with localized prostate carcinoma using simultaneous integrated boost intensity-modulated proton beam ther...

    Authors: Dalia Ahmad Khalil, Danny Jazmati, Dirk Geismar, Jörg Wulff, Christian Bäumer, Paul Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleitthoff, Sandija Plaude, Martin Bischoff, Stephan Tschirdewahn, Boris Hadaschik and Beate Timmermann
    Citation: Radiation Oncology 2022 17:64
  10. Prostate alignment is subject to interobserver variability in cone-beam CT (CBCT)-based soft-tissue matching. This study aims to analyze the impact of possible interobserver variability in CBCT-based soft-tiss...

    Authors: Xiangbin Zhang, Xin Wang, Xiaoyu Li, Li Zhou, Shihong Nie, Changhu Li, Xuetao Wang, Guyu Dai, Zhonghua Deng and Renming Zhong
    Citation: Radiation Oncology 2022 17:62
  11. This study aimed at evaluating the clinical impact of full intensity-modulated radiotherapy (IMRT), hybrid IMRT (H-IMRT) and hybrid volumetric-modulated arc therapy (H-VMAT) for early-stage breast cancer with ...

    Authors: Suyan Bi, Rui Zhu and Zhitao Dai
    Citation: Radiation Oncology 2022 17:60
  12. Previous work on Magnetic Resonance Imaging (MRI) only planning has been applied to limited treatment regions with a focus on male anatomy. This research aimed to validate the use of a hybrid multi-atlas synth...

    Authors: Laura M. O’Connor, Jason A. Dowling, Jae Hyuk Choi, Jarad Martin, Helen Warren-Forward, Haylea Richardson, Leah Best, Kate Skehan, Mahesh Kumar, Geetha Govindarajulu, Swetha Sridharan and Peter B. Greer
    Citation: Radiation Oncology 2022 17:55
  13. Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a ...

    Authors: Magdalena Garbacz, Jan Gajewski, Marco Durante, Kamil Kisielewicz, Nils Krah, Renata Kopeć, Paweł Olko, Vincenzo Patera, Ilaria Rinaldi, Marzena Rydygier, Angelo Schiavi, Emanuele Scifoni, Tomasz Skóra, Agata Skrzypek, Francesco Tommasino and Antoni Rucinski
    Citation: Radiation Oncology 2022 17:50
  14. The interplay effect of respiratory motion on the planned dose in free-breathing right-sided whole-breast irradiation (WBI) were studied by simulating hypofractionated VMAT treatment courses.

    Authors: Mikko Mankinen, Tuomas Virén, Jan Seppälä, Heikki Hakkarainen and Tuomas Koivumäki
    Citation: Radiation Oncology 2022 17:46
  15. In infrared reflective (IR) marker-based hybrid real-time tumor tracking (RTTT), the internal target position is predicted with the positions of IR markers attached on the patient’s body surface using a predic...

    Authors: Dejun Zhou, Mitsuhiro Nakamura, Nobutaka Mukumoto, Hiroaki Tanabe, Yusuke Iizuka, Michio Yoshimura, Masaki Kokubo, Yukinori Matsuo and Takashi Mizowaki
    Citation: Radiation Oncology 2022 17:42
  16. The aim of this study was to clarify the association between intrafractional prostate shift and hydrogel spacer.

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Ryosuke Takenaka, Yuki Nozawa, Yuichi Watanabe, Toshikazu Imae and Osamu Abe
    Citation: Radiation Oncology 2022 17:41
  17. Boosting dominant intra-prostatic lesions (DILs) has the potential to increase the therapeutic ratio in prostate cancer radiotherapy. In this study, employing 5-fraction stereotactic ablative radiotherapy (SAB...

    Authors: Sarah O. S. Osman, Ciaran Fairmichael, Glenn Whitten, Gavin S. Lundy, Rachel Wesselman, Melissa LaBonte Wilson, Alan R. Hounsell, Kevin M. Prise, Denise Irvine, Conor K. McGarry and Suneil Jain
    Citation: Radiation Oncology 2022 17:38
  18. This paper describes the development of a predicted electronic portal imaging device (EPID) transmission image (TI) using Monte Carlo (MC) and deep learning (DL). The measured and predicted TI were compared fo...

    Authors: Jun Zhang, Zhibiao Cheng, Ziting Fan, Qilin Zhang, Xile Zhang, Ruijie Yang and Junhai Wen
    Citation: Radiation Oncology 2022 17:31
  19. With the rapid growth of deep learning research for medical applications comes the need for clinical personnel to be comfortable and familiar with these techniques. Taking a proven approach, we developed a str...

    Authors: John C. Asbach, Anurag K. Singh, L. Shawn Matott and Anh H. Le
    Citation: Radiation Oncology 2022 17:28
  20. To develop an auxiliary GPU-accelerated proton therapy (PT) dose and LETd engine for the IBA Proteus®ONE PT system. A pediatric low-grade glioma case study is reported using FRoG during clinical practice, highlig...

    Authors: Stewart Mein, Benedikt Kopp, Anthony Vela, Pauline Dutheil, Paul Lesueur, Dinu Stefan, Jürgen Debus, Thomas Haberer, Amir Abdollahi, Andrea Mairani and Thomas Tessonnier
    Citation: Radiation Oncology 2022 17:23
  21. The evaluation of automatic segmentation algorithms is commonly performed using geometric metrics. An analysis based on dosimetric parameters might be more relevant in clinical practice but is often lacking in...

    Authors: Maria Kawula, Dinu Purice, Minglun Li, Gerome Vivar, Seyed-Ahmad Ahmadi, Katia Parodi, Claus Belka, Guillaume Landry and Christopher Kurz
    Citation: Radiation Oncology 2022 17:21
  22. The 106-Ruthenium contact plaque applicator is utilized for the treatment of intraocular tumor within a thickness of less than 6 mm. If anything obstructs the placement of the plaque applicator, the treatment ...

    Authors: Satoshi Nakamura, Naoya Murakami, Shigenobu Suzuki, Kimiteru Ito, Mihiro Takemori, Hiroki Nakayama, Keita Kaga, Takahito Chiba, Kotaro Iijima, Kana Takahashi, Tomonori Goka, Jun Itami, Hiroyuki Okamoto and Hiroshi Igaki
    Citation: Radiation Oncology 2022 17:16
  23. To evaluate the sensitivity to set up the uncertainty of VMAT plans in Nasopharyngeal carcinoma (NPC) treatment by proposing a plan robustness evaluation method.

    Authors: Zhen Ding, Xiaoyong Xiang, Qi Zeng, Jun Ma, Zhitao Dai, Kailian Kang and Suyan Bi
    Citation: Radiation Oncology 2022 17:1
  24. Boron neutron capture therapy (BNCT) for the treatment of unresectable, locally advanced, and recurrent carcinoma of the head and neck cancer has been approved by the Japanese government for reimbursement unde...

    Authors: Naonori Hu, Hiroki Tanaka, Ryo Kakino, Syuushi Yoshikawa, Mamoru Miyao, Kazuhiko Akita, Kayako Isohashi, Teruhito Aihara, Keiji Nihei and Koji Ono
    Citation: Radiation Oncology 2021 16:243
  25. Magnetic Resonance Image guided Stereotactic body radiotherapy (MRgRT) is an emerging technology that is increasingly used in treatment of visceral cancers, such as pancreatic adenocarcinoma (PDAC). Given the ...

    Authors: M. R. Tomaszewski, K. Latifi, E. Boyer, R. F. Palm, I. El Naqa, E. G. Moros, S. E. Hoffe, S. A. Rosenberg, J. M. Frakes and R. J. Gillies
    Citation: Radiation Oncology 2021 16:237
  26. The use of total body irradiation (TBI) with linac-based volumetric modulated arc therapy (VMAT) has been steadily increasing. Helical tomotherapy has been applied in TBI and total marrow irradiation to reduce...

    Authors: Takuya Uehara, Hajime Monzen, Mikoto Tamura, Masahiro Inada, Masakazu Otsuka, Hiroshi Doi, Kenji Matsumoto and Yasumasa Nishimura
    Citation: Radiation Oncology 2021 16:236
  27. Intensity-modulated radiation therapy (IMRT) and volume-modulated arc therapy (VMAT) are rather complex treatment techniques and require patient-specific quality assurance procedures. Electronic portal imaging...

    Authors: Jun Zhang, Xiuqing Li, Miaomiao Lu, Qilin Zhang, Xile Zhang, Ruijie Yang, Maria F. Chan and Junhai Wen
    Citation: Radiation Oncology 2021 16:232
  28. This study presents patient-specific quality assurance (QA) results from the first 395 clinical cases for the new helical TomoTherapy® platform (Radixact) coupled with dedicated Precision TPS.

    Authors: Marco Fusella, Samuele Cavinato, Alessandra Germani, Marta Paiusco, Nicola Pivato, Marco Andrea Rossato, Anthony Scott and Alessandro Scaggion
    Citation: Radiation Oncology 2021 16:226
  29. To communicate our institutional experience with single isocenter radiosurgery treatments for multiple brain metastases, including challenges with determining planning target volume (PTV) margins and resulting...

    Authors: Nzhde Agazaryan, Steve Tenn, Chul Lee, Michael Steinberg, John Hegde, Robert Chin, Nader Pouratian, Isaac Yang, Won Kim and Tania Kaprealian
    Citation: Radiation Oncology 2021 16:221
  30. To implement a tangential treatment technique for whole breast irradiation using the Varian Halcyon and to compare it with Elekta Synergy Agility plans.

    Authors: Anne Richter, Sonja Wegener, Kathrin Breuer, Gary Razinskas, Stefan Weick, Florian Exner, Klaus Bratengeier, Michael Flentje, Otto Sauer and Bülent Polat
    Citation: Radiation Oncology 2021 16:213
  31. In the existing application of beam-matched multiroom proton therapy system, the model based on the commissioning data from the leading treatment room was used as the shared model. The purpose of this study is...

    Authors: Yu-Hua Huang, Chunfeng Fang, Tao Yang, Lin Cao, Gaolong Zhang, Baolin Qu, Yihang Zhang, Zishen Wang and Shouping Xu
    Citation: Radiation Oncology 2021 16:206
  32. Evaluation of delivered dose to the dominant intraprostatic lesion (DIL) for moderately hypofractionated radiotherapy of prostate cancer by cone beam computed tomography (CBCT)-based dose accumulation and targ...

    Authors: Jörg Tamihardja, Sinan Cirsi, Patrick Kessler, Gary Razinskas, Florian Exner, Anne Richter, Bülent Polat and Michael Flentje
    Citation: Radiation Oncology 2021 16:205
  33. To develop high-quality synthetic CT (sCT) generation method from low-dose cone-beam CT (CBCT) images by using attention-guided generative adversarial networks (AGGAN) and apply these images to dose calculatio...

    Authors: Liugang Gao, Kai Xie, Xiaojin Wu, Zhengda Lu, Chunying Li, Jiawei Sun, Tao Lin, Jianfeng Sui and Xinye Ni
    Citation: Radiation Oncology 2021 16:202
  34. Hypoxia is known to be prevalent in solid tumors such as non-small cell lung cancer (NSCLC) and reportedly correlates with poor prognostic clinical outcome. PET imaging can provide in-vivo hypoxia measurements...

    Authors: Andreas Köthe, Nicola Bizzocchi, Sairos Safai, Antony John Lomax, Damien Charles Weber and Giovanni Fattori
    Citation: Radiation Oncology 2021 16:199
  35. In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potenti...

    Authors: Duncan den Boer, Johannes K. Veldman, Geertjan van Tienhoven, Arjan Bel and Zdenko van Kesteren
    Citation: Radiation Oncology 2021 16:188
  36. We aimed to assess the feasibility of a dose painting (DP) procedure, known as simultaneous integrated boost intensity modulated radiation Therapy (SIB-IMRT), for treating prostate cancer with dominant intrapr...

    Authors: Seyed Masoud Rezaeijo, Bijan Hashemi, Bahram Mofid, Mohsen Bakhshandeh, Arash Mahdavi and Mohammad Saber Hashemi
    Citation: Radiation Oncology 2021 16:182
  37. Contour delineation, a crucial process in radiation oncology, is time-consuming and inaccurate due to inter-observer variation has been a critical issue in this process. An atlas-based automatic segmentation w...

    Authors: Yuka Urago, Hiroyuki Okamoto, Tomoya Kaneda, Naoya Murakami, Tairo Kashihara, Mihiro Takemori, Hiroki Nakayama, Kotaro Iijima, Takahito Chiba, Junichi Kuwahara, Shouichi Katsuta, Satoshi Nakamura, Weishan Chang, Hidetoshi Saitoh and Hiroshi Igaki
    Citation: Radiation Oncology 2021 16:175
  38. To compare the dosimetric, normal tissue complication probability (NTCP), secondary cancer complication probabilities (SCCP), and excess absolute risk (EAR) differences of volumetric modulated arc therapy (VMA...

    Authors: Yun Zhang, Yuling Huang, Shenggou Ding, Xingxing Yuan, Yuxian Shu, Jinhui Liang, Qingfeng Mao, Chunling Jiang and Jingao Li
    Citation: Radiation Oncology 2021 16:171
  39. To evaluate the combined effect of rotational error and dose gradient on target dose coverage in frameless stereotactic radiotherapy.

    Authors: Jai-Woong Yoon, Soah Park, Kwang-Ho Cheong, Sei-Kwon Kang and Tae Jin Han
    Citation: Radiation Oncology 2021 16:169
  40. The objective of this study was to analyze the amplitude of translational and rotational movements occurring during stereotactic body radiotherapy (SBRT) of spinal metastases in two different positioning devic...

    Authors: Ahmed Hadj Henni, David Gensanne, Maximilien Roge, Chantal Hanzen, Guillaume Bulot, Elyse Colard and Sebastien Thureau
    Citation: Radiation Oncology 2021 16:168
  41. To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

    Authors: Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu, Yanhua Duan, Aihui Feng and Zhiyong Xu
    Citation: Radiation Oncology 2021 16:158
  42. Patient-specific dose prediction improves the efficiency and quality of radiation treatment planning and reduces the time required to find the optimal plan. In this study, a patient-specific dose prediction mo...

    Authors: Sang Hee Ahn, EunSook Kim, Chankyu Kim, Wonjoong Cheon, Myeongsoo Kim, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Dae Yong Kim and Jong Hwi Jeong
    Citation: Radiation Oncology 2021 16:154
  43. Inter-modality image registration between computed tomography (CT) and magnetic resonance (MR) images is associated with systematic uncertainties and the magnitude of these uncertainties is not well documented...

    Authors: Emilia Persson, Sevgi Emin, Jonas Scherman, Christian Jamtheim Gustafsson, Patrik Brynolfsson, Sofie Ceberg, Adalsteinn Gunnlaugsson and Lars E. Olsson
    Citation: Radiation Oncology 2021 16:150
  44. To compare the clinical outcomes of stereotactic body radiation therapy (SBRT) and fractionated radiation therapy (FRT) for primary liver cancer with portal vein tumor thrombus (PVTT).

    Authors: Sujing Zhang, Li He, Changwen Bo, Shufang Yang, Yonghui An, Na Li, Yingchun Zhao, Liping Zhao, Wenhua Ma and Zheng Zheng
    Citation: Radiation Oncology 2021 16:149
  45. A range pull-back device, such as a machine-related range shifter (MRS) or a universal patient-related range shifter (UPRS), is needed in pencil beam scanning technique to treat shallow tumors.

    Authors: Haibo Lin, Chengyu Shi, Sheng Huang, Jiajian Shen, Minglei Kang, Qing Chen, Huifang Zhai, James McDonough, Zelig Tochner, Curtiland Deville, Charles B. Simone II and Stefan Both
    Citation: Radiation Oncology 2021 16:146
  46. Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different ada...

    Authors: Miriam Eckl, Gustavo R. Sarria, Sandra Springer, Marvin Willam, Arne M. Ruder, Volker Steil, Michael Ehmann, Frederik Wenz and Jens Fleckenstein
    Citation: Radiation Oncology 2021 16:145

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