Skip to main content

Evaluation of inter- and intra-fraction 6D motion for stereotactic body radiation therapy of spinal metastases: influence of treatment time



The objective of this study was to analyze the amplitude of translational and rotational movements occurring during stereotactic body radiotherapy (SBRT) of spinal metastases in two different positioning devices. The relevance of intra-fractional imaging and the influence of treatment time were evaluated.


Twenty patients were treated in the supine position either (1) on a body vacuum cushion with arms raised and resting on a clegecel or (2) on an integrated SBRT solution consisting of a SBRT table top, an Orfit™ AIO system, and a vacuum cushion. Alignments between the cone beam computed tomography (CBCT) and the planning computed tomography allowed corrections of inter- and intra-fraction positional shifts using a 6D table. The absolute values of the translational and rotational setup errors obtained for 329 CBCT were recorded. The translational 3D vector, the maximum angle, and the characteristic times of the treatment fractions were calculated.


An improvement in the mean (SD) inter-fraction 3D vector (mm) from 7.8 (5.9) to 5.9 (3.8) was obtained by changing the fixation devices from (1) to (2) (p < 0.038). The maximum angles were less than 2° for a total of 87% for (1) and 96% for (2). The mean (SD) of the intra-fraction 3D vectors (mm) was lower for the new 1.1 (0.8) positioning fixation (2) compared to the old one (1) 1.7 (1.7) (p = 0.004). The angular corrections applied in the intra-fraction were on average very low (0.4°) and similar between the two systems. A strong correlation was found between the 3D displacement vector and the fraction time for (1) and (2) with regression coefficients of 0.408 (0.262–0.555, 95% CI) and 0.069 (0.010–0.128, 95% CI), respectively. An accuracy of 1 mm would require intra-fraction imaging every 5 min for both systems. If the expected accuracy was 2 mm, then only system (2) could avoid intra-fractional imaging.


This study allowed us to evaluate setup errors of two immobilization devices for spine SBRT. The association of inter- and intra-fraction imaging with 6D repositioning of a patient is inevitable. The correlation between treatment time and corrections to be applied encourages us to move toward imaging modalities which allow a reduction in fraction time.


Stereotactic body radiotherapy (SBRT) is a technique based on the concept of image-guided radiation therapy (IGRT) with very high precision that delivers high doses with a strong gradient associated with reduced margins. The objective is to obtain a high biological effective dose in a limited number of fractions. Stereotactic radiotherapy of spinal metastases can achieve (depending on the number of fractions and selected dose) local control at 1 year estimated to be between 80.6 and 92.7% according to a recent review of the literature including data from 38 studies [1].

The particular difficulty in this location is the millimetric proximity of the planning target volume (PTV) to nerve structures (spinal cord, cauda equina). Large dose gradients in the direction of these structures imply that greater precision must be guaranteed at all stages of patient management. A lack of precision can lead to serious side effects such as radiation myelopathy [2]. Spinal metastases SBRT fundamentally requires the use of accurate multimodal imaging [3], a ballistic using intensity modulation that can achieve a high degree of conformity in the irradiation of concave targets, and an image-guidance strategy associated with an immobilization system guaranteeing the accuracy of radiation delivery.

At the implementation of the technique in our center in 2018, several cone beam computed tomography (CBCT) scans were performed before and during treatment associated with a treatment table allowing submillimeter movements with six degrees of freedom. An initial vacuum cushion device was used (Pos_Old) and replaced in July 2019 with an integrated SBRT solution (Pos_New). This change was made to homogenize our immobilization practices to increase the comfort, accuracy and reproducibility of patient positioning. CBCT Imaging performed before and during treatment was acquired to minimize positioning errors.

The objective of this study was to quantify the amplitude of translational (vertical, longitudinal, and lateral) and rotational (pitch, yaw, and roll) movements in spinal metastasis SBRT using inter- and intra-fractional CBCT imaging. The relevance of intra-fraction imaging, which increases the time of treatment fraction, and the influence of this parameter on the offset errors were evaluated. This study also allowed the evaluation of two methods of immobilization, one based on the use of a half-body vacuum bag widely used in radiotherapy centers, and the other on a commercial solution completely integrated and indexed to the table, which is not yet studied in the literature to our knowledge. As our old positioning system (Pos_Old) was widely used for other treatment sites (e.g. lung) prior to the implementation of spinal SBRT, the radiotherapy technologists were therefore used to this type of positioning system. For the new device (Pos_New), the radiotherapy technologists received training from the vendor before use. It was also used for other treament sites. Therefore, the results have not been influenced by the users’ experience.

These results were compared with those of other studies to evaluate our practices and our level of positioning accuracy as recommended by learned societies such as the UK consortium [4].


Our retrospective study received the institutional consent necessary for its realization. The clinical data analyzed were from a cohort of 20 patients treated at our center with stereotactic radiotherapy for one or more spinal lesions. The period covered was from February 2018 to September 2020.

Patients and dosimetric planning

All 20 patients were in the supine position. Ten were placed in a half-body vacuum bag (VacQfix™; Qfix, Avondale, PA, USA) with their arms raised and resting on a clegecel (Pos_Old, Fig. 1a). The remaining ten were placed on an integrated SBRT solution consisting of an SBRT tabletop, an Orfit™ AIO system (Orfit Industries NV, Wijnegem, Belgium), and half-body vacuum bag (Pos_New, Fig. 1b).

Fig. 1

Patient positioning systems: a vacuum cushion, arms raised and resting on a clegecel and b AIO Orfit™ system and vacuum cushion

CT imaging was acquired with a slice thickness of 1.25 mm [3] centered on the secondary bone lesion. Spinal MRI in the treatment position was also performed according to a standardized protocol combining 3D T2 and T1 sequences with gadolinium injection with a 1 mm isotropic voxel size.

The gross target volume (GTV) was delineated by experienced radiation oncologists after registration of the different imaging modalities (CT, MRI and PET CT if available). The clinical target volume (CTV) was adapted according to the anatomical vertebral bone segment invaded by the GTV as specified in international recommendations [5,6,7]. A margin of 2 mm was applied from the CTV to obtain the PTV. This margin was reduced to 0 mm, closed to the spinal cord.

All treatments were performed with volumetric modulated arc therapy (VMAT) according to our dosimetric protocol based on three coplanar arcs in 6MV photons at 600 MU/min and collimator angles of 45°, 315° and 95°. All treatment plans were calculated using the same planning system (Eclipse AAA 13.6.23, 0.125 cm grid size; Varian Medical Systems).

Irradiation and imaging strategy during treatment

All patients were planned on a Truebeam Stx (Varian Medical Systems, Palo Alto, CA, USA) dedicated to stereotactic treatment and equipped with an MLC 120HD (high definition), an on-board imager (OBI) and a PerfectPitch table with six degrees of freedom. The quality controls performed on our linear accelerator were those recommended by learned societies with tolerance thresholds adapted to the level of requirements expected in stereotactic treatment [3].

To ensure optimal patient positioning, a pre-treatment CBCT (CBCTpTT) and CBCT between each of the three arcs (CBCT12 and CBCT23) were acquired corresponding to our intra-fraction imaging (CBCT12 + 23). CBCT scans were acquired with a gantry rotation of 360° (120 kV, 80 mA) with a slice spacing of 1.98 mm and pixel resolution of 0.91 mm and registered with a planning CT with a slice spacing of 1.25 mm and pixel resolution of 0.94 mm.

A senior radiation oncologist was present during treatment. The standardized approach was to first perform a manual bone registration on a large region of interest to avoid any possibility of vertebral error and then to automatically perform a registration on the volume of interest. Online automatic registration between the CBCT and planning CT was verified by a physician and manually adjusted when it was necessary and systematically applied using the 6D treatment table (accuracy of 0.1 mm/0.1°).

Analysis methodology

Positional errors were collected for each CBCT via the Aria Offline review module (ARIA 13.6; Varian Medical System, Palo Alto, CA) for the three translational (mm) lateral (X, LR), vertical (Y, AP), and longitudinal (Z, CC) and rotational (°) pitch (Rx), yaw (Ry) and roll (Rz) motions. The absolute values of the mean, standard deviation, and maximum value of each motion were calculated. A 3D displacement vector (3D Vect = \(\sqrt {{X^2} + {Y^2} + {Z^2}}\)) and the maximum angle of the rotations (Max Angle = Max(RX, Ry, Rz)) were deduced.

Typical treatment fraction times were also calculated using the Aria Offline Review tool. The total treatment time of a session was counted from the beginning of the CBCTpTT acquisition to the completion of the last arc (arc 3). The first characteristic intra-fraction time was calculated from the start of the CBCTpTT acquisition to the start of the CBCT12 acquisition. The second intra-fraction time recorded corresponded to the time between the start of CBCT12 and the start of CBCT23. These two times were related to the offsets given by CBCT12 and CBCT23.

Two groups of data were compared corresponding to the two immobilization systems used. The significance of this comparison was assessed using a non-parametric Mann–Whitney test. The results were associated with a p value with a threshold value of 0.05 below which the difference was considered significant. The evidence of a link between the treatment time and 3D translational deviation (3D Vect) was based on the results of Pearson (r, p value) and Spearman (rho, p value) correlation coefficients. All statistical tests were performed using the XLSTAT statistical software (version 2020.5).


Overview of a spine SBRT treatment

In our cohort of 20 patients, 22 vertebrae were treated with stereotactic radiotherapy. Of these patients, 35% (n = 7) were men and 65% (n = 13) were women with a median age of 66 years (range, 48–76 years). Breast cancer was the most common primary cancer (50%) followed by prostate cancer (25%), lung cancer (20%) and small bowel cancer (5%).

The most frequent histological types were adenocarcinoma (55%) for bronchial tumors and infiltrating ductal carcinomas (35%) for breast tumors. One patient (5%) had an infiltrating lobular carcinoma and one patient had a neuroendocrine tumor (5%).

Vertebral lesions were treated in thoracic spine cases (55%), lumbar spine cases (41%), and sacrum cases (4%). The series included only one adjuvant situation on a single vertebra (postoperative). All patients received treatment at a dose of 35 Gy in 5 fractions of 7 Gy, three times a week, on an average GTV of 9.96 cm3 and an average CTV of 32.35 cm3. Patient and treatment characteristics are summarized in Table 1.

Table 1 Patients and treatment characteristics

A total of 110 treatment fractions and 329 CBCT scans were retrospectively analyzed allowing us to evaluate our level of accuracy in the inter-fraction (110 CBCTpTT) and intra-fraction (110 CBCT12 and 109 CBCT23) for two different immobilization systems (179 Pos_Old and 150 Pos_New).

The mean (SD) characteristic data of the spinal stereotactic treatment fraction at our center were calculated. The number of MUs delivered per arc was 837 (198) MUs. When the old positioning device (Pos_Old) was used, the total treatment time (Imaging + irradiation) was 20.4 (3.7) min versus 17.1 (4.2) min for the new system (Pos_New) (p < 0.0001). The beam-on time (arc1 + arc2 + arc3) was 4.4 (0.8) min.

Inter and intra-fraction results

The mean absolute(SD) inter-fraction setup errors for six degrees of freedom are listed in Table 2. The results for the 3D translation vector and maximum rotation angle are presented in Table 3.

Table 2 Summary of translational and rotational deviation of each positioning system for each type of CBCT
Table 3. 3D vector (mm) and max angle (°) calculated for each positioning system for each CBCT type

Inter-fraction results

The absolute offsets from the CBCTpTT allowed us to evaluate the reproducibility of patient positioning in each immobilization devices. The means(SD) of the 3D vectors for the two immobilization systems Pos_Old and Pos_New were respectively 7.8 (5.9) mm and 5.9 (3.8) mm with a significant difference (p = 0.038). However, the difference observed between the means (SD) of the maximum angles, 1.5 (0.6)° for Pos_Old and 1.4 (0.5)° for Pos_New, was not statistically significant (p = 0.10). The results obtained for each of the translations and each of the rotations are detailed in the CBCTpTT section of Table 2.

The CBCTpTT(Pos_Old) and CBCTpTT(Pos_New) curves in Fig. 2 represent the proportion (%) of treatment fractions setup errors within given tolerance, translational (3D Vect on top) and rotational (MaxAngle at the bottom), measured on pre-treatment CBCTs. For translational movements the comparaison of the two immobilization systems was performed using a 3D tolerance equal to 3.5 mm corresponding to setup errors of 2 mm in the three axes. In terms of rotation, a value of 2° represented the threshold beyond which the dosimetric impact was considered significant [8].

Fig. 2

Proportion (%) of treatment fractions setup errors within given tolerance, translational (3D Vect on top) and rotational (MaxAngle at the bottom), measured on pre-treatment (CBCTpTT) and intra fractions (CBCT12 + 23) CBCTs. The thresholds denoted be a red line represent a 3D vector = 3.5 mm corresponding to a setup errors of 2 mm in the 3 directions and a maximum rotation angle of 2°

Intra-fraction results

The results (mean, SD, and maximum value) for each translational and rotational intra-fraction offset applied (CBCT12 + CBCT23) for both immobilization systems are summarized in Table 2.

The means (SD) of the 3D vectors were significantly lower for the new fixation device 1.1 (0.8) mm compared to the old positioning system 1.7 (1.7) mm (p = 0.004) (Table 3). Corresponding to our tolerance of 3.5 mm, 87.5% and 98.5% of the intra-fraction CBCT offsets for Pos_Old and Pos_New respectively were below this threshold.

No significant difference (p = 0.9) was observed in the mean (SD) of the maximum angle (°) applied during the treatment fraction between Pos_Old 0.4 (0.4)° and Pos_New 0.4 (0.3)°. Although these results showed a relatively small angular correction in the intra-fraction, the maximum value of this angle was 2.5° for Pos_Old but remained below 2° for Pos_New (1.9°). In terms of frequency, Fig. 2 shows a similar behavior of the two positioning systems; for example, 98% and 100% of the maximum rotational errors were less than 2° for Pos_Old and Pos_New respectively, showing identical accuracy for the 2 patient immobilization strategies.

Treatment time and intra-fraction translational movements

Figure 3 shows the relationship between the 3D intra-fraction vector recorded between each arc and the treatment time. The latter represents the interval between either the start of CBCTpTT and the start of CBCT12 or between the start of CBCT12 and the start of CBCT23. These two durations correspond to intra-fraction times.

Fig. 3

Relationship between intra-fraction 3D Vector (CBCT12 + 23) motion (mm) for Pos_Old (solid blue dots) and Pos_New (empty red dots) as a function of time (min) measured either between CBCTpTT start and CBCT12 start or between CBCT12 start and CBCT23 start. The linear fits are shown with their corresponding equations

Our statistical tests, Pearson correlation coefficient (r, p value) and Spearman rank correlation coefficient (rho, p value), showed an increasing linear correlation between the 3D displacement vectors and time for the old positioning device Pos_Old (r = 0. 454, p < 0.0001) and (rho = 0.391, p < 0.0001), and the new positioning device Pos_New (r = 0.228, p < 0.021) and (rho = 0.383, p < 0.0001). Linear fits for Pos_Old and Pos_New are also presented in Fig. 3, with regression coefficients of 0.408 (0.262–0.555, 95% CI) and 0.069 (0.010–0.128, 95% CI), respectively. An estimate of the times by solving the two equations that involved exceeding our 3D threshold by 3.5 mm yielded 11.28 min for the old immobilization system and a time outside the characteristics of our spine stereotactic treatment fractions (41.7 min) for the new one. However, an expected accuracy of 1 mm in all directions (Vect 3D = 1.7 mm) would require intra-fractional imaging approximately every 5 min for the Pos_Old (5.2 min) and Pos_New (5.4 min) fixation devices.


The analysis of CBCT data before the beginning of the treatment fraction (CBCTpTT) and during (CBCT12 + 23) allowed us to evaluate our patient positioning practices and, consequently, determine if our margins were sufficient. This approach is strongly recommended by learned societies [4]. In fact, for spinal SBRT in France in 2016 [9], 71% used imaging during treatment.

Our results and a literature review on the subject led us to make improvements in the management of our patients treated for spinal metastasis with stereotactic body radiation therapy.

The comparison between the two positioning systems confirms our choice in favor of the new immobilization device. The inter-fraction positioning (CBCTpTT) was improved by the change from Pos_Old to Pos_New, both in translation and rotation; however, only 19.5% and 33%, respectively, of the 3D translational motions were less than a 3D threshold of 3.5 mm. These offsets found, and applied, during initial patient positioning (CBCTpTT) are relatively large regardless of the immobilization devices (see Tables 2, 3). To take into account this result an additional verification imaging was added just prior to treatment. This verification CBCT allows to assess the residual setup error after the initial image registration. This methodology is similar to the practice of 76% of the centers in France [9] and has also been reported in international literature [10, 11].

Wang et al. [8] considered that a loss of target volume coverage greater than 5% and an increase greater than 25% in the maximum dose to the OARs leads to significant dosimetric effects. Their goal, based on their study conducted on patients and phantoms, was to achieve a positioning accuracy for treatment ≤ 1 mm in translation and ≤ 2° in rotation. For GuckenBerger et al. [12], the dosimetric impact on the spinal cord was acceptable for maximum errors ≤ 1 mm and ≤ 3.5° on average.

In terms of frequency, 87% and 96% of rotations were less than 2° for the two immobilization devices Pos_Old and Pos_New respectively, with maximum values not exceeding 3°. Nevertheless, to guarantee the optimal accuracy, achieved by the new positioning system, we will continue to use accelerators equipped with a 6D table. According to a survey by Pougnet et al. [8], 81% of French centers use a 6D table to correct their positioning errors.

Concerning intra-fraction imaging, a review of the literature allowed us to compare our two types of fixation devices to the results reported by different studies [10, 11, 13, 14]. To evaluate our level of intra-fraction accuracy, we based the comparison on the standard deviations of the positioning errors, which are common to all the articles cited (Table 4).

Table 4 Comparison of standard deviations (SD) in mm of intra-fraction positioning errors found in the literature as well as the Pos_Old and Pos_New positioning systems

The Pos_Old system had the highest SD in the cranio-caudal (CC) direction (1.5 mm) among the positioning devices described in Table 4. However, the results obtained by our commercial Pos_New immobilization system were comparable to more rigid ones (BodyFIX, Medical Intelligence, Elekta, Schwabmunchen, Germany) when compared to Hyde et al. [11] and even slightly better when compared to Li et al. [10]. The advantage of the Pos_New system is that it is much less restrictive than a system using a polyethylene sheet under vacuum and is less time-consuming for pretreament setup. In addition, in the case of VMAT, the position of the arms along the body of the BodyFix device [10, 11] can restrict the number of radiation beam entries in order to reduce low dose to this organ. It should be noted that a simple Posirest [14] positioning system provided results close to those obtained by Hyde et al. [11] and our new Pos_New system. From this result, we postulate that arm immobilization is a determining factor for improving positioning quality. This hypothesis could explain why the old immobilization strategy based on the use of a vacuum cushion is inferior to that reported by Li et al. [10] and Foster et al. [13] with similar materials. Moreover, the standard deviation in the cranio-caudal direction 1.5 mm greater than the other two directions may confirm this hypothesis. Immobilization based on the use of a thermoformed mask for cervical locations [10] is classified at the same level of precision as a vacuum cushion.

The intra-fraction accuracy of our Pos_New system in translation and rotation (98.5% of 3D Vect ≤ 3.5 mm and 100% of Max Angle ≤ 2°, Fig. 2) could allow us to dispense with CBCT between each arc for a gain in treatment time. However, the analysis of the maximum values (respectively for 3D Vect and Max Angle 5.7 mm and 1.9°) leads us to keep intra-fraction imaging. The imaging systems on Truebeam Stx (Varian Medical Systems, Palo Alto, CA, USA) have the capability to perform triggered imaging (depending on MU, time or degrees) during irradiation. However, this only allows visual verification by juxtaposing the target volume contour on the kV2D acquisition. Another possibility is to opt for non-embedded kV-2D systems whose image acquisition is fast and allow an automatic registration without interruption of the beam delivery. Chang et al. [15] for example validated phantoms and patients with the kV-2D Exactrac system from Brainlab (Brainlab AG, Munich, Germany) as an alternative to CBCT in spine SBRT. Oh et al. [16] and Wang et al. [17] conducted the same study for intracranial and head and neck stereotactic radiotherapy respectively, and validated this system. However, the authors pointed out that precautions must be taken if this type of imaging is used alone.

In contrast to the results presented by Dahele et al. [14] for a Posirest positioning system, we found a strong correlation between the magnitude of 3D translation errors and intra-fraction time. If the goal is to achieve an accuracy of ≤ 1 mm, imaging should be performed every 5 min regardless of the fixation devices studied. The rotational intra-fraction offsets were well below 1°. These results are consistent with those presented in 2009 by Ma et al. [18]. Ma et al. determined the time of realization of a control imaging to maintain an accuracy of ≤ 1 mm and ≤ 1° to be between 5 and 7 min. If the goal is a precision of 2 mm, then the new Pos_New system theoretically allows the discarding of intra-fraction imaging.

These results should encourage teams to focus on optimizing the workflow of their treatment fraction to minimize positioning errors and the loss of biological effectiveness highlighted by several publications [19, 20] beyond a treatment time of more than 30 min.

In a larger study aiming at calculating the margins to be used, it would be necessary to evaluate the inter and intra observer registration error as well as the impact of the CBCT image quality on the automatic image registration. This uncertainty is typically much larger [21,22,23] than the accuracy allowed by 6D table (0.1 mm/0.1°). We had a cohort of 20 patients for 22 vertebrae with a total of 329 CBCT analyzed (110 CBCTpTT + 219 CBCT12 + 23) that allowed us to obtain statistically significant conclusions. For comparison, Dahele et al. [14] used data from 249 intra-fraction CBCTs; Finnigan et al. [24] used 225 image registrations. Li et al. [10] used a total of 355 localizations, 333 verifications, and 248 mid- and 280 post-treatment CBCTs. Other studies have used larger statistics, Foster et al. [13] for example used SBRT data from 141 lung, 29 liver, 48 prostate and 45 spine tumors.

This study dealt mainly with lumbar and thoracic locations. Cervical lesions whose immobilization system was based on thermoformed masks were not included in the results. As other locations outside the vertebrae (scapula, humerus) where patient positioning can sometimes be complicated, even if the proximity of sensitive OARs is less important. Moreover, CBCT acquired during treatment does not provide the exact moment when a patient's movements occur. Studies that use real-time imaging to track patient motion during irradiation could answer this question more accurately [25]. The use of flattening filter free (FFF) beams is also a tool for improving the speed of delivery of radiation verified from doses per fraction of 4 Gy in X6FFF and 10 Gy in X10FFF while keeping dosimetric results equivalent to filtered beams [26,27,28].


In summary, this study evaluated setup errors of two immobilization devices used in the management of spinal stereotactic body radiation therapy. Improvements were made that increased the level of treatment accuracy. The correlation between treatment time and intra-fraction motion leads to the use of faster imaging modalities reducing the treatment time per fraction.

Availability of data and materials

All data and materials have been presented in the manuscript.



Stereotactic body radiation therapy


Computed tomography


Cone-beam computed tomography


Magnetic resonance imaging


Positron emission tomography


Gross target volume


Planning target volume


Clinical target volume


Volumetric modulated arc therapy


Analytical anisotropic algorithm


Standard deviation








  1. 1.

    Gong Y, Xu L, Zhuang H, Jiang L, Wei F, Liu Z, et al. Efficacy and safety of different fractions in stereotactic body radiotherapy for spinal metastases: a systematic review. Cancer Med. 2019;8(14):6176–84.

    Article  Google Scholar 

  2. 2.

    Khan M, Ambady P, Kimbrough D, Shoemaker T, Terezakis S, Blakeley J, et al. Radiation-induced myelitis: initial and follow-up MRI and clinical features in patients at a single tertiary care institution during 20 years. Am J Neuroradiol. 2018;39:1576–81.

    CAS  Article  Google Scholar 

  3. 3.

    Benedict SH, Yenice KM, Followill D, Galvin JM, Hinson W, Kavanagh B, Keall P, Lovelock M, et al. Stereotactic body radiation therapy: the report of AAPM Task Group 101. Med Phys. 2010;37:4078.

    Article  Google Scholar 

  4. 4.

    Lee J et al. Stereotactic ablative body radiation therapy (SABR): a resource SABR UK consortium. Endorsed by The Faculty of Clinical Oncology of the Royal College of Radiologists. Version 6.1, January 2019

  5. 5.

    Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, et al. International spine radiosurgery consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery. Int J Radiat Oncol. 2012;83(5):e597-605.

    Article  Google Scholar 

  6. 6.

    Dunne EM, Sahgal A, Lo SS, Bergman A, Kosztyla R, Dea N, et al. International consensus recommendations for target volume delineation specific to sacral metastases and spinal stereotactic body radiation therapy (SBRT). Radiother Oncol. 2020;145:21–9.

    Article  Google Scholar 

  7. 7.

    Redmond KJ, Lo SS, Soltys SG, Yamada Y, Barani IJ, Brown PD, et al. Consensus guidelines for postoperative stereotactic body radiation therapy for spinal metastases: results of an international survey. J Neurosurg Spine. 2017;26(3):299–306.

    Article  Google Scholar 

  8. 8.

    Wang H, Shiu A, Wang C, O’Daniel JC, Mahajan A, Woo S, et al. Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2008;71(4):1261–71.

    Article  Google Scholar 

  9. 9.

    Pougnet I, Jaegle E, Garcia R, Tessier F, Faivre JC, Louvel G, et al. Spinal stereotactic body radiotherapy: French assessment in 2016. Cancer/Radiothérapie xxx (2017)

  10. 10.

    Li W, Sahgal A, Foote M, Millar BA, Jaffray DA, Letourneau D, et al. Impact of immobilization on intrafraction motion for spine stereotactic body radiotherapy using cone beam computed tomography. Int J Radiat Oncol Biol Phys. 2012;84(2):520–6.

    Article  Google Scholar 

  11. 11.

    Hyde D, Lochray F, Korol R, Davidson M, Wong CS, Lijun M, et al. Spine stereotactic body radiotherapy utilizing cone beam CT image-guidance with a robotic couch: intrafraction motion analysis accounting for all six degrees of freedom. Int J Radiat Oncol Biol Phys. 2012;82(3):e555–62.

    Article  Google Scholar 

  12. 12.

    GuckenBerger M, Meyer J, Wilbert J, Baier K, Bratengeier K, Vordermark D, et al. Precision required for dose-escalated treatment of spinal metastases and implications for image-guided radiation therapy (IGRT). Radiother Oncol. 2007;84:56–63.

    Article  Google Scholar 

  13. 13.

    Foster R, Meyer J, Iyengar P, Pistenmaa D, Timmerman R, Choy H, et al. Localization accuracy and immobilization effectiveness of a stereotactic body frame for a variety of treatment sites. Int J Radiat Oncol Biol Phys. 2013;87(5):911–6.

    Article  Google Scholar 

  14. 14.

    Dahele M, Slotman B, Verbakel W. Stereotactic body radiotherapy for spine and bony pelvis using flattening filter free volumetric modulated arc therapy, 6D cone-beam CT and simple positioning techniques: Treatment time and patient stability. Acta Oncol. 2016;55(6):795–8.

    Article  Google Scholar 

  15. 15.

    Chang Z, Wang Z, Ma J, O’Daniel JC, Kirkpatrick J, Yin FF. 6D image guidance for spinal non invasive stereotactic body radiation therapy: comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT. Radiother Oncol. 2010;95:116–21.

    Article  Google Scholar 

  16. 16.

    Oh SA, Park JW, Yea JW, Kim SK. Evaluations of the setup discrepancy between BrainLAB 6D ExacTrac and cone-beam computed tomography used with the imaging guidance system Novalis-Tx for intracranial stereotactic radiosurgery. PLoS ONE. 2017;12(5):e0177798.

    Article  Google Scholar 

  17. 17.

    Wang H, Wang C, Tung S, Dimmitt AW, Wong PF, Edson MA, et al. Improved setup and positioning accuracy using a three-point customized cushion/mask/bite-block immobilization system for stereotactic reirradiation of head and neck cancer. J Appl Clin Med Phys. 2016;17(3):180–9.

    Article  Google Scholar 

  18. 18.

    Ma L, Sahgal A, Hossain S, Chuang C, Descovich M, Huang K, et al. Nonrandom intrafraction target motions and general strategy for correction of spine stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009;75(4):1261–5.

    Article  Google Scholar 

  19. 19.

    Fowler J, Welsh JS, Howard SP. Loss of biological effect in prolonged fraction delivery. Int J Radiat Oncol Biol Phys. 2004;59(1):242–9.

    Article  Google Scholar 

  20. 20.

    Joiner MC, Mogili N, Marples B, Burmeister J. Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations. Med Phys. 2010;37(6):2457–65.

    CAS  Article  Google Scholar 

  21. 21.

    Barber J, Sykes JR, Holloway L, Thwaites DI Automatic image registration performance for two different CBCT systems; variation with imaging dose. In : Journal of Physics: Conference Series, vol 489, p 012070 (2014)

  22. 22.

    Takei Y, Monzen H, Matsumoto K, Hanaoka K, Tamura M, Nishimura Y. Registration accuracy with the low dose kilovoltage cone-beam CT: a phantom study. BJR Open. 2019;1:20190028.

    PubMed  PubMed Central  Google Scholar 

  23. 23.

    Fox T, Huntzinger C, Johnstone P, Ogunleye T, Elder E. Performance evaluation of an automated image registration algorithm using an integrated kilovoltage imaging and guidance system. J Appl Clin Med Phys. 2006;7(1):97–104.

    Article  Google Scholar 

  24. 24.

    Finnigan R, Lamprecht B, Barry T, Jones K, Boyd J, Pullar A, et al. Inter- and intra-fraction motion in stereotactic body radiotherapy for spinal and paraspinal tumours using cone-beam CT and positional correction in six degrees of freedom. J Med Imaging Radiat Oncol. 2016;60:112–8.

    Article  Google Scholar 

  25. 25.

    Hazelaar C, Dahele M, Mostafavi H, Van der Weide L, Slotman BJ, Verbakel W. Subsecond and submillimeter resolution positional verification for stereotactic irradiation of spinal lesions. Int J Radiat Oncol Biol Phys. 2016;94(5):1154–62.

    Article  Google Scholar 

  26. 26.

    Vieillevigne L, Bessieres S, Ouali M, Lanaspeze C. Dosimetric comparison of flattened and unflattened beams for stereotactic body radiation therapy: impact of the size of the PTV on dynamic conformal arc and volumetric modulated arc therapy

  27. 27.

    Reggiori G, Mancosu P, Castiglioni S, Alongi F, Pellegrini C, Lobefalo F, et al. Can volumetric modulated arc therapy with flattening filter free beams play a role in stereotactic body radiotherapy for liver lesions? A volume-based analysis. Med Phys. 2012;39:1112.

    Article  Google Scholar 

  28. 28.

    Hrbacek J, Lang S, Graydon SN, Klöck S, Riesterer O. Dosimetric comparison of flattened and unflattened beams for stereotactic ablative radiotherapy of stage I non-small cell lung cancer. Med Phys. 2014;41:031709.

    Article  Google Scholar 

Download references


All authors in this study and many colleagues helped to collect and analyze data. Thanks for their assistance.


The authors have no funding to report.

Author information




Participation has included (1) substantial contributions to the conception and design of the work or the acquisition, analysis or interpretation of data; AND (2) drafting the article or revising it critically for important intellectual content; AND (3) final approval of the version to be published. AHH, DG, MR and ST contributed to (1) + (2) + (3). CH, contributed to (2) + (3), GB and EC to (1) + (2). All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ahmed Hadj Henni.

Ethics declarations

Ethics approval and consent to participate

Our retrospective study received the institutional consent necessary for its realization. Eligible patients were given written informed consent.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Hadj Henni, A., Gensanne, D., Roge, M. et al. Evaluation of inter- and intra-fraction 6D motion for stereotactic body radiation therapy of spinal metastases: influence of treatment time. Radiat Oncol 16, 168 (2021).

Download citation


  • SBRT
  • CBCT
  • Spinal
  • Inter-fraction
  • Intra-fraction
  • Treatment time