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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late di...

    Authors: Q. Li, S. H. Maier, P. Li, J. Peterhansl, C. Belka, J. Mayerle and U. M. Mahajan

    Citation: Radiation Oncology 2020 15:189

    Content type: Review

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  2. We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation ind...

    Authors: Martin Selmansberger, Agata Michna, Herbert Braselmann, Ines Höfig, Kenji Schorpp, Peter Weber, Natasa Anastasov, Horst Zitzelsberger, Julia Hess and Kristian Unger

    Citation: Radiation Oncology 2020 15:182

    Content type: Research

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  3. The evaluation of circulating tumour DNA (ctDNA) from clinical blood samples, liquid biopsy, offers several diagnostic advantages compared with traditional tissue biopsy, such as shorter processing time, reduc...

    Authors: G. M. Walls, L. McConnell, J. McAleese, P. Murray, T. B. Lynch, K. Savage, G. G. Hanna and D. Gonzalez de Castro

    Citation: Radiation Oncology 2020 15:132

    Content type: Research

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  4. Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) is upregulated in CC cells upon radia...

    Authors: Jing-Jie Zheng, Yue He, Yang Liu, Feng-Shuang Li, Zhen Cui, Xiao-Meng Du, Chun-Peng Wang and Yu-Mei Wu

    Citation: Radiation Oncology 2020 15:131

    Content type: Research

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  5. Prognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model de...

    Authors: Daniel Samaga, Roman Hornung, Herbert Braselmann, Julia Hess, Horst Zitzelsberger, Claus Belka, Anne-Laure Boulesteix and Kristian Unger

    Citation: Radiation Oncology 2020 15:109

    Content type: Research

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  6. Radiotherapy used in tumor treatment compromises vascularization of bone tissue. Hyperbaric oxygenation (HBO) increases oxygen availability and improves vascularization, minimizing the deleterious effects of i...

    Authors: Luiz Henrique Ferreira Júnior, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Paula Dechichi, Letícia de Souza Castro Filice, Paulo Sérgio Quagliatto and Flaviana Soares Rocha

    Citation: Radiation Oncology 2020 15:95

    Content type: Research

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  7. The aim of this study was to characterize changes in hippocampal inflammasomes, pyroptosis and apoptosis in juvenile rats after brain irradiation and to assess whether manganese-enhanced magnetic resonance ima...

    Authors: Jun Yang, Jingyan Gao, Dan Han, Qinqing Li, Chengde Liao, Jindan Li, Rui Wang and Yueyuan Luo

    Citation: Radiation Oncology 2020 15:78

    Content type: Research

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  8. Sublethal radiation induces matrix metalloproteinase 9 (MMP-9)-mediated radioresistance in Lewis lung carcinoma (LLC) cells and their metastatic dissemination. We aim to determine if EGFR/HER2 activation assoc...

    Authors: Yun Tien, Chiao-Ling Tsai, Wei-Hsien Hou, Yun Chiang, Feng-Ming Hsu, Yu-Chieh Tsai and Jason Chia-Hsien Cheng

    Citation: Radiation Oncology 2020 15:58

    Content type: Research

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  9. Despite aggressive treatment regimens comprising surgery and radiochemotherapy, glioblastoma (GBM) remains a cancer entity with very poor prognosis. The development of novel, combined modality approaches neces...

    Authors: Benjamin Stegen, Alexander Nieto, Valerie Albrecht, Jessica Maas, Michael Orth, Klement Neumaier, Sabine Reinhardt, Moritz Weick-Kleemann, Wilfried Goetz, Merle Reinhart, Katia Parodi, Claus Belka, Maximilian Niyazi and Kirsten Lauber

    Citation: Radiation Oncology 2020 15:19

    Content type: Research

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  10. To determine the relative biological effectiveness (RBE) and α/β-values after fractionated carbon ion irradiations of the rat spinal cord with varying linear energy transfer (LET) to benchmark RBE-model calculati...

    Authors: Maria Saager, Christin Glowa, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2020 15:6

    Content type: Research

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  11. Individual radiosensitivity is influencing the outcome of radiation therapy. A general ex vivo testing is very work-intensive. It is of interest to see if a significant prediction concerning the sensitivity ca...

    Authors: Theresa Mayo, Marlen Haderlein, Barbara Schuster, Anna Wiesmüller, Christian Hummel, Maximilian Bachl, Manfred Schmidt, Rainer Fietkau and Luitpold Distel

    Citation: Radiation Oncology 2019 15:2

    Content type: Research

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  12. Treatment options for recurrent head and neck tumours in the previously irradiated area are limited, including re-irradiation due to radioresistance of the recurrent tumour and previous dose received by surrou...

    Authors: Vesna Todorovic, Ajda Prevc, Martina Niksic Zakelj, Monika Savarin, Andreja Brozic, Blaz Groselj, Primoz Strojan, Maja Cemazar and Gregor Sersa

    Citation: Radiation Oncology 2019 14:214

    Content type: Research

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  13. Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...

    Authors: Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol and David Azria

    Citation: Radiation Oncology 2019 14:142

    Content type: Research

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  14. Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber

    Citation: Radiation Oncology 2019 14:141

    Content type: Review

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  15. Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the sti...

    Authors: Sarah Hartfiel, Matthias Häfner, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Jürgen Debus, Peter E. Huber and Nils H. Nicolay

    Citation: Radiation Oncology 2019 14:119

    Content type: Research

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  16. Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolom...

    Authors: Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos and Ingeborg Goethals

    Citation: Radiation Oncology 2019 14:89

    Content type: Research

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  17. Breast cancer is the most common invasive tumor in women worldwide and the second cause of cancer-related deaths. After breast conserving surgery the tumor bed gets irradiated. Radiation-induced tumor cell dea...

    Authors: Anna Rothammer, Eva K. Sage, Caroline Werner, Stephanie E. Combs and Gabriele Multhoff

    Citation: Radiation Oncology 2019 14:78

    Content type: Research

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  18. Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation b...

    Authors: Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray and David Argyle

    Citation: Radiation Oncology 2019 14:64

    Content type: Research

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  19. Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might in...

    Authors: Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero and Irenäus A. Adamietz

    Citation: Radiation Oncology 2019 14:25

    Content type: Research

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  20. The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.

    Authors: Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Eduardo Tadashi Pinto Emi, Camila de Carvalho Almança Lopes, Flaviana Soares Rocha, Jonas Dantas Batista, Gustavo Davi Rabelo and Paula Dechichi

    Citation: Radiation Oncology 2019 14:15

    Content type: Research

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  21. The implementation of magnetic resonance imaging (MRI) guided radiotherapy (RT) continues to increase. Very limited in-vitro data on the interaction of ionizing radiation and magnetic fields (MF) have been pub...

    Authors: B. Yudhistiara, F. Zwicker, K. J. Weber, P. E. Huber, A. Ruehle, S. Brons, P. Haering, J. Debus and S. H. Hauswald

    Citation: Radiation Oncology 2019 14:11

    Content type: Research

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  22. Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this stud...

    Authors: Hui Lu, Qi Zhao, Jiang Guo, Binghui Zeng, Xinlin Yu, Dongsheng Yu and Wei Zhao

    Citation: Radiation Oncology 2019 14:5

    Content type: Research

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  23. Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently availab...

    Authors: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio and Panu M. Jaakkola

    Citation: Radiation Oncology 2018 13:220

    Content type: Research

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  24. HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.

    Authors: Ning Li, Dan-dan Meng, Ling Gao, Yue Xu, Pei-jie Liu, Yong-wei Tian, Zhen-ying Yi, Yan Zhang, Xiao-jing Tie and Zhi-qiao Xu

    Citation: Radiation Oncology 2018 13:210

    Content type: Research

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  25. Concomitant chemo-radiotherapy is the reference treatment for non-resectable locally-advanced Non-Small Cell Lung Cancer (NSCLC). Increasing radiotherapy total dose in the whole tumour volume has been shown to...

    Authors: Sébastien Thureau, Bernard Dubray, Romain Modzelewski, Pierre Bohn, Sébastien Hapdey, Sabine Vincent, Elodie Anger, David Gensanne, Nicolas Pirault, Gouel Pierrick and Pierre Vera

    Citation: Radiation Oncology 2018 13:208

    Content type: Research

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  26. Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, for non-inflammatory locally advanced breast cancer (LABC) patients, preoperative radiotherapy (pRT) ...

    Authors: Miljana Tanić, Ana Krivokuća, Milena Čavić, Jasmina Mladenović, Vesna Plesinac Karapandžić, Stephan Beck, Siniša Radulović, Snezana Susnjar and Radmila Janković

    Citation: Radiation Oncology 2018 13:193

    Content type: Research

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  27. Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular per...

    Authors: Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, Laura Marucci, Filomena Spasiano, Irene Terrenato and Giuseppe Sanguineti

    Citation: Radiation Oncology 2018 13:189

    Content type: Research

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  28. Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-i...

    Authors: Yue Zhou, Xiaowu Sheng, Feiyan Deng, Hui Wang, Liangfang Shen, Yong Zeng, Qianxi Ni, Shibin Zhan and Xiao Zhou

    Citation: Radiation Oncology 2018 13:160

    Content type: Research

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  29. Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways.

    Authors: Dasantha Jayamanne, Helen Wheeler, David Brazier, Allison Newey, Marina Kastelan, Linxin Guo and Michael Back

    Citation: Radiation Oncology 2018 13:133

    Content type: Research

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  30. Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain ...

    Authors: Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster and Eugene Wong

    Citation: Radiation Oncology 2018 13:104

    Content type: Research

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  31. Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administratio...

    Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue and G. Hildebrandt

    Citation: Radiation Oncology 2018 13:89

    Content type: Research

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  32. The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity of the disease and the lack of randomi...

    Authors: Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Tae Gyu Kim and Jin Ho Song

    Citation: Radiation Oncology 2018 13:85

    Content type: Research

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  33. Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235...

    Authors: Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti and Antonio Daga

    Citation: Radiation Oncology 2018 13:76

    Content type: Short Report

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  34. The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radi...

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe and Keiichi Nakagawa

    Citation: Radiation Oncology 2018 13:70

    Content type: Research

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  35. The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into t...

    Authors: Yushi Wakisaka, Masashi Yagi, Iori Sumida, Masaaki Takashina, Kazuhiko Ogawa and Masahiko Koizumi

    Citation: Radiation Oncology 2018 13:30

    Content type: Research

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  36. The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

    Content type: Research

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  37. As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Authors: Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt

    Citation: Radiation Oncology 2017 12:159

    Content type: Research

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  38. Radiotherapy plays a major role in the management of high grade glioma. However, the radioresistance of glioma cells limits its efficiency and drives recurrence inside the irradiated tumor volume leading to po...

    Authors: Julian Biau, Emmanuel Chautard, Leanne De Koning, Frank Court, Bruno Pereira, Pierre Verrelle and Marie Dutreix

    Citation: Radiation Oncology 2017 12:123

    Content type: Research

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  39. Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    Authors: P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Citation: Radiation Oncology 2017 12:120

    Content type: Research

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  40. Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Authors: Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto

    Citation: Radiation Oncology 2017 12:111

    Content type: Research

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  41. Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-sur...

    Authors: Shing Yau Tam, Vincent Wing Cheung Wu and Helen Ka Wai Law

    Citation: Radiation Oncology 2017 12:57

    Content type: Review

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  42. Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Authors: Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2017 12:26

    Content type: Research

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  43. In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Authors: Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki

    Citation: Radiation Oncology 2016 11:153

    Content type: Research

    Published on:

  44. Hadron therapy is an innovative technique where cancer cells are precisely killed leaving surrounding healthy cells least affected by high linear energy transfer (LET) radiation like carbon ion beam. Anti-meta...

    Authors: Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh

    Citation: Radiation Oncology 2016 11:126

    Content type: Research

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