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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. Content type: Research

    Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...

    Authors: Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol and David Azria

    Citation: Radiation Oncology 2019 14:142

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  2. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber

    Citation: Radiation Oncology 2019 14:141

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  3. Content type: Research

    Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the sti...

    Authors: Sarah Hartfiel, Matthias Häfner, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Jürgen Debus, Peter E. Huber and Nils H. Nicolay

    Citation: Radiation Oncology 2019 14:119

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  4. Content type: Research

    Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolom...

    Authors: Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos and Ingeborg Goethals

    Citation: Radiation Oncology 2019 14:89

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  5. Content type: Research

    Breast cancer is the most common invasive tumor in women worldwide and the second cause of cancer-related deaths. After breast conserving surgery the tumor bed gets irradiated. Radiation-induced tumor cell dea...

    Authors: Anna Rothammer, Eva K. Sage, Caroline Werner, Stephanie E. Combs and Gabriele Multhoff

    Citation: Radiation Oncology 2019 14:78

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  6. Content type: Research

    Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation b...

    Authors: Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray and David Argyle

    Citation: Radiation Oncology 2019 14:64

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  7. Content type: Research

    Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might in...

    Authors: Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero and Irenäus A. Adamietz

    Citation: Radiation Oncology 2019 14:25

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  8. Content type: Research

    The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.

    Authors: Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Eduardo Tadashi Pinto Emi, Camila de Carvalho Almança Lopes, Flaviana Soares Rocha, Jonas Dantas Batista, Gustavo Davi Rabelo and Paula Dechichi

    Citation: Radiation Oncology 2019 14:15

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  9. Content type: Research

    The implementation of magnetic resonance imaging (MRI) guided radiotherapy (RT) continues to increase. Very limited in-vitro data on the interaction of ionizing radiation and magnetic fields (MF) have been pub...

    Authors: B. Yudhistiara, F. Zwicker, K. J. Weber, P. E. Huber, A. Ruehle, S. Brons, P. Haering, J. Debus and S. H. Hauswald

    Citation: Radiation Oncology 2019 14:11

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  10. Content type: Research

    Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this stud...

    Authors: Hui Lu, Qi Zhao, Jiang Guo, Binghui Zeng, Xinlin Yu, Dongsheng Yu and Wei Zhao

    Citation: Radiation Oncology 2019 14:5

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  11. Content type: Research

    Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently availab...

    Authors: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio and Panu M. Jaakkola

    Citation: Radiation Oncology 2018 13:220

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  12. Content type: Research

    HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.

    Authors: Ning Li, Dan-dan Meng, Ling Gao, Yue Xu, Pei-jie Liu, Yong-wei Tian, Zhen-ying Yi, Yan Zhang, Xiao-jing Tie and Zhi-qiao Xu

    Citation: Radiation Oncology 2018 13:210

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  13. Content type: Research

    Concomitant chemo-radiotherapy is the reference treatment for non-resectable locally-advanced Non-Small Cell Lung Cancer (NSCLC). Increasing radiotherapy total dose in the whole tumour volume has been shown to...

    Authors: Sébastien Thureau, Bernard Dubray, Romain Modzelewski, Pierre Bohn, Sébastien Hapdey, Sabine Vincent, Elodie Anger, David Gensanne, Nicolas Pirault, Gouel Pierrick and Pierre Vera

    Citation: Radiation Oncology 2018 13:208

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  14. Content type: Research

    Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, for non-inflammatory locally advanced breast cancer (LABC) patients, preoperative radiotherapy (pRT) ...

    Authors: Miljana Tanić, Ana Krivokuća, Milena Čavić, Jasmina Mladenović, Vesna Plesinac Karapandžić, Stephan Beck, Siniša Radulović, Snezana Susnjar and Radmila Janković

    Citation: Radiation Oncology 2018 13:193

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  15. Content type: Research

    Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular per...

    Authors: Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, Laura Marucci, Filomena Spasiano, Irene Terrenato and Giuseppe Sanguineti

    Citation: Radiation Oncology 2018 13:189

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  16. Content type: Research

    Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-i...

    Authors: Yue Zhou, Xiaowu Sheng, Feiyan Deng, Hui Wang, Liangfang Shen, Yong Zeng, Qianxi Ni, Shibin Zhan and Xiao Zhou

    Citation: Radiation Oncology 2018 13:160

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  17. Content type: Research

    Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways.

    Authors: Dasantha Jayamanne, Helen Wheeler, David Brazier, Allison Newey, Marina Kastelan, Linxin Guo and Michael Back

    Citation: Radiation Oncology 2018 13:133

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  18. Content type: Research

    Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain ...

    Authors: Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster and Eugene Wong

    Citation: Radiation Oncology 2018 13:104

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  19. Content type: Research

    Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administratio...

    Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue and G. Hildebrandt

    Citation: Radiation Oncology 2018 13:89

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  20. Content type: Research

    The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity of the disease and the lack of randomi...

    Authors: Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Tae Gyu Kim and Jin Ho Song

    Citation: Radiation Oncology 2018 13:85

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  21. Content type: Short Report

    Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235...

    Authors: Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti and Antonio Daga

    Citation: Radiation Oncology 2018 13:76

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  22. Content type: Research

    The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radi...

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe and Keiichi Nakagawa

    Citation: Radiation Oncology 2018 13:70

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  23. Content type: Research

    The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into t...

    Authors: Yushi Wakisaka, Masashi Yagi, Iori Sumida, Masaaki Takashina, Kazuhiko Ogawa and Masahiko Koizumi

    Citation: Radiation Oncology 2018 13:30

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  24. Content type: Research

    The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

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  25. Content type: Research

    As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Authors: Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt

    Citation: Radiation Oncology 2017 12:159

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  26. Content type: Research

    Radiotherapy plays a major role in the management of high grade glioma. However, the radioresistance of glioma cells limits its efficiency and drives recurrence inside the irradiated tumor volume leading to po...

    Authors: Julian Biau, Emmanuel Chautard, Leanne De Koning, Frank Court, Bruno Pereira, Pierre Verrelle and Marie Dutreix

    Citation: Radiation Oncology 2017 12:123

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  27. Content type: Research

    Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    Authors: P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Citation: Radiation Oncology 2017 12:120

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  28. Content type: Research

    Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Authors: Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto

    Citation: Radiation Oncology 2017 12:111

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  29. Content type: Review

    Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-sur...

    Authors: Shing Yau Tam, Vincent Wing Cheung Wu and Helen Ka Wai Law

    Citation: Radiation Oncology 2017 12:57

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  30. Content type: Research

    Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Authors: Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2017 12:26

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  31. Content type: Research

    In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Authors: Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki

    Citation: Radiation Oncology 2016 11:153

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  32. Content type: Research

    Hadron therapy is an innovative technique where cancer cells are precisely killed leaving surrounding healthy cells least affected by high linear energy transfer (LET) radiation like carbon ion beam. Anti-meta...

    Authors: Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh

    Citation: Radiation Oncology 2016 11:126

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  33. Content type: Research

    Intracavitary irradiation plays a pivotal role in definitive radiotherapy for cervical cancer, and the Ir-192 high dose-rate remote afterloading system (HDR-RALS) is often used for this purpose. Under this con...

    Authors: Taito Asahina, Atsushi Kaida, Tatsuaki Goto, Ryo-Ichi Yoshimura, Keisuke Sasai and Masahiko Miura

    Citation: Radiation Oncology 2016 11:99

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  34. Content type: Research

    Acquired and inherent radioresistance of tumor cells is related to tumor relapse and poor prognosis – not only in head and neck squamous cell carcinoma (HNSCC). The underlying molecular mechanisms are largely ...

    Authors: Agata Michna, Ulrike Schötz, Martin Selmansberger, Horst Zitzelsberger, Kirsten Lauber, Kristian Unger and Julia Hess

    Citation: Radiation Oncology 2016 11:94

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  35. Content type: Research

    Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and i...

    Authors: Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami and Akihiko Kondo

    Citation: Radiation Oncology 2016 11:91

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  36. Content type: Research

    O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and...

    Authors: Marc D. Piroth, Norbert Galldiks, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Johannes Ermert, Felix M. Mottaghy, N. Jon Shah, Karl-Josef Langen and Michael J. Eble

    Citation: Radiation Oncology 2016 11:87

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  37. Content type: Research

    Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is...

    Authors: Johann Matschke, Elisa Wiebeck, Sebastian Hurst, Justine Rudner and Verena Jendrossek

    Citation: Radiation Oncology 2016 11:75

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  38. Content type: Research

    To study the dose-response of stage I non-small-cell lung cancer (NSCLC) in terms of long-term local tumor control (LC) after conventional and hypofractionated photon radiotherapy, modeled with the linear-quad...

    Authors: Alina Santiago, Steffen Barczyk, Urszula Jelen, Rita Engenhart-Cabillic and Andrea Wittig

    Citation: Radiation Oncology 2016 11:67

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  39. Content type: Research

    Risk of normal tissue toxicity limits the amount of thoracic radiation therapy (RT) that can be routinely prescribed to treat non-small cell lung cancer (NSCLC). An early biomarker of response to thoracic RT m...

    Authors: Tru-Khang T. Dinh, Wojciech Fendler, Justyna Chałubińska-Fendler, Sanket S. Acharya, Colin O’Leary, Peter V. Deraska, Alan D. D’Andrea, Dipanjan Chowdhury and David Kozono

    Citation: Radiation Oncology 2016 11:61

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  40. Content type: Research

    This study investigates the implementation of a new intensity modulated arc therapy (IMAT) class solution in comparison to a 6-static beam step-and-shoot intensity modulated radiotherapy (s-IMRT) for three-pha...

    Authors: Dieter Berwouts, Luiza Ana Maria Olteanu, Bruno Speleers, Frédéric Duprez, Indira Madani, Tom Vercauteren, Wilfried De Neve and Werner De Gersem

    Citation: Radiation Oncology 2016 11:52

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  41. Content type: Research

    Glioblastomas progress rapidly making response evaluation using MRI insufficient since treatment effects are not detectable until months after initiation of treatment. Thus, there is a strong need for suppleme...

    Authors: Lina Mörén, Carl Wibom, Per Bergström, Mikael Johansson, Henrik Antti and A. Tommy Bergenheim

    Citation: Radiation Oncology 2016 11:51

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  42. Content type: Research

    Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to radiotherapy alone. In this study biological modelling is a...

    Authors: J. Crezee, C. M. van Leeuwen, A. L. Oei, L. E. van Heerden, A. Bel, L. J. A. Stalpers, P. Ghadjar, N. A. P. Franken and H. P. Kok

    Citation: Radiation Oncology 2016 11:14

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  43. Content type: Research

    The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of r...

    Authors: Yu-Zhe Song, Mei-Na Duan, Yu-Yu Zhang, Wei-Yan Shi, Cheng-Cheng Xia and Li-Hua Dong

    Citation: Radiation Oncology 2015 10:247

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  44. Content type: Research

    Tumour hypoxia promotes radioresistance and is associated with poor prognosis. The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor (HIF)-...

    Authors: Markus Mandl, Maria- Katharina Lieberum, Juergen Dunst and Reinhard Depping

    Citation: Radiation Oncology 2015 10:229

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  45. Content type: Research

    Local tumor control by standard fractionated radiotherapy (RT) remains poor because of tumor resistance to radiation (radioresistance). It has been suggested that cancer stem cells (CSCs) are more radioresista...

    Authors: Yuhchyau Chen, Fuquan Zhang, Ying Tsai, Xiadong Yang, Li Yang, Shanzhou Duan, Xin Wang, Peter Keng and Soo Ok Lee

    Citation: Radiation Oncology 2015 10:227

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  46. Content type: Research

    Our previous data demonstrated that targeting non-homologous end-joining repair (NHEJR) yields a higher radiosensitivity than targeting homologous recombination repair (HRR) to heavy ions using DNA repair gene...

    Authors: Hongyu Ma, Akihisa Takahashi, Yukari Yoshida, Akiko Adachi, Tatsuaki Kanai, Tatsuya Ohno and Takashi Nakano

    Citation: Radiation Oncology 2015 10:225

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