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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. As one of the most common chromosomal causes, chromosome translocation leads to T-cell acute lymphoblastic leukemia (T-ALL). Ku70 is one of the key factors of error-prone DNA repair and it may end in transloca...

    Authors: Zhenbo Cheng, Yupeng Wang, Lihuang Guo, Jiancheng Li, Wei Zhang, Conghui Zhang, Yangxu Liu, Yue Huang and Keqian Xu
    Citation: Radiation Oncology 2022 17:144
  2. There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect ob...

    Authors: Pankaj Chaudhary, Deborah C. Gwynne, Boris Odlozilik, Aaron McMurray, Giuliana Milluzzo, Carla Maiorino, Domenico Doria, Hamad Ahmed, Lorenzo Romagnani, Aaron Alejo, Hersimerjit Padda, James Green, David Carroll, Nicola Booth, Paul McKenna, Satyabrata Kar…
    Citation: Radiation Oncology 2022 17:77
  3. Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for...

    Authors: Simon Deycmar, Elisabeth Mara, Sylvia Kerschbaum-Gruber, Verena Waller, Dietmar Georg and Martin Pruschy
    Citation: Radiation Oncology 2022 17:72
  4. Radiotherapy is an effective regimen for cancer treatment alone or combined with chemotherapy or immunotherapy. The direct effect of radiotherapy involves radiation-induced DNA damage, and most studies have fo...

    Authors: Lei Wang, Jizong Jiang, Yuan Chen, Qingzhu Jia and Qian Chu
    Citation: Radiation Oncology 2022 17:63
  5. Prostate cancer (PCa) is known to be suitable for hypofractionated radiotherapy due to the very low α/β ratio (about 1.5–3 Gy). However, several randomized controlled trials have not shown the superiority of h...

    Authors: Ming Cui, Xian-Shu Gao, Xiaoying Li, Mingwei Ma, Xin Qi and Yuta Shibamoto
    Citation: Radiation Oncology 2022 17:54
  6. Radiotherapy (RT) is a mainstay of treatment for patients with glioblastoma (GB). Early clinical trials show that short course hypofractionation showed no survival benefit compared to conventional regimens wit...

    Authors: Kelly J. McKelvey, Amanda L. Hudson, Heather Donaghy, Shihani P. Stoner, Helen R. Wheeler, Connie I. Diakos and Viive M. Howell
    Citation: Radiation Oncology 2022 17:17
  7. Stereotactic body radiotherapy (SBRT) is increasingly used for treatment of liver tumors but the effect on metabolic liver function in surrounding tissue is largely unknown. Using 2-deoxy-2-[18F]fluoro-d-galactos...

    Authors: Michael Sørensen, Mette Marie Fode, Jørgen Baltzer Petersen, Marianne Ingerslev Holt and Morten Høyer
    Citation: Radiation Oncology 2021 16:192
  8. Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radia...

    Authors: Lina Wang, Xiaohu Wang, Guangwen Zhang, Yan Ma, Qiuning Zhang, Zheng Li, Juntao Ran, Xiaoming Hou, Yichao Geng, Zheng Yang, Shuangwu Feng, Chengcheng Li and Xueshan Zhao
    Citation: Radiation Oncology 2021 16:187
  9. Invasiveness is a major factor contributing to metastasis of tumour cells. Given the broad variety and plasticity of invasion mechanisms, assessing potential metastasis-promoting effects of irradiation for spe...

    Authors: Jia Mei, Claudia Böhland, Anika Geiger, Iris Baur, Kristina Berner, Steffen Heuer, Xue Liu, Laura Mataite, M. Camila Melo-Narváez, Erdem Özkaya, Anna Rupp, Christian Siebenwirth, Felix Thoma, Matthias F. Kling and Anna A. Friedl
    Citation: Radiation Oncology 2021 16:159
  10. Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuxim...

    Authors: Raik Schneider, Günther Gademann, Hans-Joachim Ochel, Karsten Neumann, Burkhard Jandrig, Peter Hass, Mathias Walke, Martin Schostak, Thomas Brunner and Frank Christoph
    Citation: Radiation Oncology 2021 16:137
  11. Pathological complete response (pathCR) in rectal cancer is beneficial, as up to 75% of patients do not experience regrowth of the primary tumour, but it is poorly understood. We hypothesised that the changes ...

    Authors: Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, Ian Geh, João D. Barros-Silva and Andrew D. Beggs
    Citation: Radiation Oncology 2021 16:129
  12. The recent implementation of MR-Linacs has highlighted theranostic opportunities of contrast agents in both imaging and radiotherapy. There is a lack of data exploring the potential of superparamagnetic iron o...

    Authors: Emily Russell, Victoria Dunne, Ben Russell, Hibaaq Mohamud, Mihaela Ghita, Stephen J. McMahon, Karl T. Butterworth, Giuseppe Schettino, Conor K. McGarry and Kevin M. Prise
    Citation: Radiation Oncology 2021 16:104
  13. This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients.

    Authors: Lourdes Cruz-Garcia, Christophe Badie, Selvakumar Anbalagan, Jayne Moquet, Lone Gothard, Grainne O’Brien, Navita Somaiah and Elizabeth A. Ainsbury
    Citation: Radiation Oncology 2021 16:83
  14. Radiation-induced myelopathy is a severe and irreversible complication that occurs after a long symptom-free latency time if the spinal cord was exposed to a significant irradiation dose during tumor treatment...

    Authors: Thomas Welzel, Alina L. Bendinger, Christin Glowa, Inna Babushkina, Manfred Jugold, Peter Peschke, Jürgen Debus, Christian P. Karger and Maria Saager
    Citation: Radiation Oncology 2021 16:63
  15. Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/ne...

    Authors: Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda and Peigen Huang
    Citation: Radiation Oncology 2021 16:48
  16. Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor...

    Authors: Somayeh Sadat Mehrnia, Bijan Hashemi, Seyed Javad Mowla, Maryam Nikkhah and Azim Arbabi
    Citation: Radiation Oncology 2021 16:33
  17. Radiation-induced brain injury is a common concern for survivors of adult and pediatric brain cancer. Pre-clinically, rodent models are the standard approach to evaluate mechanisms of injury and test new thera...

    Authors: Ilektra Athanasiadi, Whitney D. Perez, Jeannie M. Plantenga, Yava Jones-Hall and Carlos J. Perez-Torres
    Citation: Radiation Oncology 2021 16:30
  18. Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of seconda...

    Authors: Javier Franco-Pérez, Sergio Montes, Josué Sánchez-Hernández and Paola Ballesteros-Zebadúa
    Citation: Radiation Oncology 2020 15:269
  19. Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50–60% of patients. It is part of therapy for around 40% of cancer patients who are cured of their disease. Until recently, the f...

    Authors: Madyson Colton, Eleanor J. Cheadle, Jamie Honeychurch and Tim M. Illidge
    Citation: Radiation Oncology 2020 15:254
  20. Methods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim se...

    Authors: Antonello E. Spinelli, Andrea Bresolin, Stefania Zuppone, Laura Perani, Giuseppe Fallara, Nadia Di Muzio, Riccardo Vago, Claudio Fiorino and Cesare Cozzarini
    Citation: Radiation Oncology 2020 15:240
  21. Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s...

    Authors: Qing Jin, Cunzhi Lin, Xinhong Zhu, Yiwei Cao, Caihong Guo and Lijun Wang
    Citation: Radiation Oncology 2020 15:238

    The Correction to this article has been published in Radiation Oncology 2021 16:214

  22. Radiotherapy (RT) is applied in 45–60% of all cancer patients either alone or in multimodal therapy concepts comprising surgery, RT and chemotherapy. However, despite technical innovations approximately only 5...

    Authors: Kexu Xiang, Verena Jendrossek and Johann Matschke
    Citation: Radiation Oncology 2020 15:197
  23. Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late di...

    Authors: Q. Li, S. H. Maier, P. Li, J. Peterhansl, C. Belka, J. Mayerle and U. M. Mahajan
    Citation: Radiation Oncology 2020 15:189
  24. We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation ind...

    Authors: Martin Selmansberger, Agata Michna, Herbert Braselmann, Ines Höfig, Kenji Schorpp, Peter Weber, Natasa Anastasov, Horst Zitzelsberger, Julia Hess and Kristian Unger
    Citation: Radiation Oncology 2020 15:182
  25. The evaluation of circulating tumour DNA (ctDNA) from clinical blood samples, liquid biopsy, offers several diagnostic advantages compared with traditional tissue biopsy, such as shorter processing time, reduc...

    Authors: G. M. Walls, L. McConnell, J. McAleese, P. Murray, T. B. Lynch, K. Savage, G. G. Hanna and D. Gonzalez de Castro
    Citation: Radiation Oncology 2020 15:132
  26. Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) is upregulated in CC cells upon radia...

    Authors: Jing-Jie Zheng, Yue He, Yang Liu, Feng-Shuang Li, Zhen Cui, Xiao-Meng Du, Chun-Peng Wang and Yu-Mei Wu
    Citation: Radiation Oncology 2020 15:131
  27. Prognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model de...

    Authors: Daniel Samaga, Roman Hornung, Herbert Braselmann, Julia Hess, Horst Zitzelsberger, Claus Belka, Anne-Laure Boulesteix and Kristian Unger
    Citation: Radiation Oncology 2020 15:109
  28. Radiotherapy used in tumor treatment compromises vascularization of bone tissue. Hyperbaric oxygenation (HBO) increases oxygen availability and improves vascularization, minimizing the deleterious effects of i...

    Authors: Luiz Henrique Ferreira Júnior, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Paula Dechichi, Letícia de Souza Castro Filice, Paulo Sérgio Quagliatto and Flaviana Soares Rocha
    Citation: Radiation Oncology 2020 15:95
  29. The aim of this study was to characterize changes in hippocampal inflammasomes, pyroptosis and apoptosis in juvenile rats after brain irradiation and to assess whether manganese-enhanced magnetic resonance ima...

    Authors: Jun Yang, Jingyan Gao, Dan Han, Qinqing Li, Chengde Liao, Jindan Li, Rui Wang and Yueyuan Luo
    Citation: Radiation Oncology 2020 15:78
  30. Sublethal radiation induces matrix metalloproteinase 9 (MMP-9)-mediated radioresistance in Lewis lung carcinoma (LLC) cells and their metastatic dissemination. We aim to determine if EGFR/HER2 activation assoc...

    Authors: Yun Tien, Chiao-Ling Tsai, Wei-Hsien Hou, Yun Chiang, Feng-Ming Hsu, Yu-Chieh Tsai and Jason Chia-Hsien Cheng
    Citation: Radiation Oncology 2020 15:58
  31. Despite aggressive treatment regimens comprising surgery and radiochemotherapy, glioblastoma (GBM) remains a cancer entity with very poor prognosis. The development of novel, combined modality approaches neces...

    Authors: Benjamin Stegen, Alexander Nieto, Valerie Albrecht, Jessica Maas, Michael Orth, Klement Neumaier, Sabine Reinhardt, Moritz Weick-Kleemann, Wilfried Goetz, Merle Reinhart, Katia Parodi, Claus Belka, Maximilian Niyazi and Kirsten Lauber
    Citation: Radiation Oncology 2020 15:19
  32. To determine the relative biological effectiveness (RBE) and α/β-values after fractionated carbon ion irradiations of the rat spinal cord with varying linear energy transfer (LET) to benchmark RBE-model calculati...

    Authors: Maria Saager, Christin Glowa, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger
    Citation: Radiation Oncology 2020 15:6
  33. Individual radiosensitivity is influencing the outcome of radiation therapy. A general ex vivo testing is very work-intensive. It is of interest to see if a significant prediction concerning the sensitivity ca...

    Authors: Theresa Mayo, Marlen Haderlein, Barbara Schuster, Anna Wiesmüller, Christian Hummel, Maximilian Bachl, Manfred Schmidt, Rainer Fietkau and Luitpold Distel
    Citation: Radiation Oncology 2019 15:2
  34. Treatment options for recurrent head and neck tumours in the previously irradiated area are limited, including re-irradiation due to radioresistance of the recurrent tumour and previous dose received by surrou...

    Authors: Vesna Todorovic, Ajda Prevc, Martina Niksic Zakelj, Monika Savarin, Andreja Brozic, Blaz Groselj, Primoz Strojan, Maja Cemazar and Gregor Sersa
    Citation: Radiation Oncology 2019 14:214
  35. Biomarkers for predicting late normal tissue toxicity to radiotherapy are necessary to personalize treatments and to optimize clinical benefit. Many radiogenomic studies have been published on this topic. Conv...

    Authors: Jérôme Lacombe, Muriel Brengues, Alain Mangé, Céline Bourgier, Sophie Gourgou, André Pèlegrin, Mahmut Ozsahin, Jérôme Solassol and David Azria
    Citation: Radiation Oncology 2019 14:142
  36. Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor prognosis and rising incidence. Late detection and a particularly aggressive biology are the major challenges which determine t...

    Authors: Michael Orth, Philipp Metzger, Sabine Gerum, Julia Mayerle, Günter Schneider, Claus Belka, Maximilian Schnurr and Kirsten Lauber
    Citation: Radiation Oncology 2019 14:141
  37. Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the sti...

    Authors: Sarah Hartfiel, Matthias Häfner, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Jürgen Debus, Peter E. Huber and Nils H. Nicolay
    Citation: Radiation Oncology 2019 14:119
  38. Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolom...

    Authors: Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos and Ingeborg Goethals
    Citation: Radiation Oncology 2019 14:89
  39. Breast cancer is the most common invasive tumor in women worldwide and the second cause of cancer-related deaths. After breast conserving surgery the tumor bed gets irradiated. Radiation-induced tumor cell dea...

    Authors: Anna Rothammer, Eva K. Sage, Caroline Werner, Stephanie E. Combs and Gabriele Multhoff
    Citation: Radiation Oncology 2019 14:78
  40. Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation b...

    Authors: Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray and David Argyle
    Citation: Radiation Oncology 2019 14:64
  41. Radiotherapy is administered in more than 60% of all solid tumors. Most patients are cured but a significant number develops local recurrences or distant metastases. The question arises if irradiation might in...

    Authors: Pascaline Nguemgo Kouam, Helmut Bühler, Thomas Hero and Irenäus A. Adamietz
    Citation: Radiation Oncology 2019 14:25
  42. The aim of this study was to evaluate the ionizing radiation (IR) effects on rat bone 30 and 60 days after irradiation.

    Authors: Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Eduardo Tadashi Pinto Emi, Camila de Carvalho Almança Lopes, Flaviana Soares Rocha, Jonas Dantas Batista, Gustavo Davi Rabelo and Paula Dechichi
    Citation: Radiation Oncology 2019 14:15
  43. The implementation of magnetic resonance imaging (MRI) guided radiotherapy (RT) continues to increase. Very limited in-vitro data on the interaction of ionizing radiation and magnetic fields (MF) have been pub...

    Authors: B. Yudhistiara, F. Zwicker, K. J. Weber, P. E. Huber, A. Ruehle, S. Brons, P. Haering, J. Debus and S. H. Hauswald
    Citation: Radiation Oncology 2019 14:11
  44. Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this stud...

    Authors: Hui Lu, Qi Zhao, Jiang Guo, Binghui Zeng, Xinlin Yu, Dongsheng Yu and Wei Zhao
    Citation: Radiation Oncology 2019 14:5

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