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  1. Content type: Research

    Local recurrences after breast conserving treatment are mainly close to the original tumor site, and as such shorter fractionation strategies focused on and nearest mammary gland, i.e. accelerated partial brea...

    Authors: Laura Lozza, Laura Fariselli, Marco Sandri, Mario Rampa, Valentina Pinzi, Maria Carmen De Santis, Marzia Franceschini, Giovanna Trecate, Ilaria Maugeri, Luisa Fumagalli, Francesca Bonfantini, Giulia Bianchi, Emanuele Pignoli, Elena De Martin and Roberto Agresti

    Citation: Radiation Oncology 2018 13:49

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  2. Content type: Research

    To investigate the feasibility and geometric accuracy of carina-based registration for CBCT-guided setup verification in esophageal cancer IGRT, compared with current practice bony anatomy-based registration.

    Authors: Mélanie Machiels, Peng Jin, Christianne H. van Gurp, Jeanin E. van Hooft, Tanja Alderliesten and Maarten C. C. M. Hulshof

    Citation: Radiation Oncology 2018 13:48

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  3. Content type: Research

    To scrutinize the pretreatment prognosticators on survival and late toxicities in a homogenous cohort of nasopharyngeal carcinoma (NPC) patients treated by simultaneous integrated boost intensity-modulated rad...

    Authors: Yun-Hsuan Lin, Tai-Lin Huang, Chih-Yen Chien, Hui-Chun Chen, Hsuan-Chih Hsu, Eng-Yen Huang, Chong-Jong Wang, Yu-Jie Huang, Yu-Ming Wang, Chun-Chieh Huang, Shang-Yu Chou, Kuan-Cho Liao and Fu-Min Fang

    Citation: Radiation Oncology 2018 13:45

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  4. Content type: Research

    Cytoreductive nephrectomy is thought to improve survival in metastatic renal cell carcinoma (mRCC). As many patients are ineligible for major surgery, we hypothesized that SABR could be a safe alternative.

    Authors: Rohann J. M. Correa, Belal Ahmad, Andrew Warner, Craig Johnson, Mary J. MacKenzie, Stephen E. Pautler, Glenn S. Bauman, George B. Rodrigues and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:47

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  5. Content type: Research

    The aim of this study was to evaluate the performance of a commercial knowledge-based planning system, in volumetric modulated arc therapy for prostate cancer at multiple radiation therapy departments.

    Authors: Yoshihiro Ueda, Jun-ichi Fukunaga, Tatsuya Kamima, Yumiko Adachi, Kiyoshi Nakamatsu and Hajime Monzen

    Citation: Radiation Oncology 2018 13:46

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  6. Content type: Research

    Clinical pathways outline criteria for dose homogeneity and critical organ dosimetry. Based upon an internal audit showing suboptimal compliance with dosimetric parameters in whole breast irradiation (WBI), we...

    Authors: Katherine S. Chen, Scott M. Glaser, Allison E. Garda, John A. Vargo, M. Saiful Huq, Dwight E. Heron and Sushil Beriwal

    Citation: Radiation Oncology 2018 13:44

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  7. Content type: Research

    Cancer patients frequently search the Internet for treatment options, and hospital websites are seen as reliable sources of knowledge. Guidelines support the use of proton radiotherapy in specific disease site...

    Authors: Mark T. Corkum, Wei Liu, David A. Palma, Glenn S. Bauman, Robert E. Dinniwell, Andrew Warner, Mark V. Mishra and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:43

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  8. Content type: Research

    Conventional phantom-based planar dosimetry (2D-PBD) quality assurance (QA) using gamma pass rate (GP (%)) is inadequate to reflect clinically relevant dose error in intensity-modulated radiation therapy (IMRT...

    Authors: Wen-zhao Sun, Dan-dan Zhang, Ying-lin Peng, li Chen, De-hua Kang, Bin Wang and Xiao-wu Deng

    Citation: Radiation Oncology 2018 13:42

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    The Correction to this article has been published in Radiation Oncology 2018 13:117

  9. Content type: Research

    To appraise the dosimetric features and the quality of the treatment plan for radiosurgery of multiple brain metastases optimized with a novel automated engine and to compare with plans optimized for robotic-b...

    Authors: Krzysztof Slosarek, Barbara Bekman, Jacek Wendykier, Aleksandra Grządziel, Antonella Fogliata and Luca Cozzi

    Citation: Radiation Oncology 2018 13:41

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  10. Content type: Research

    Esophageal cancer is an aggressive disease with poor survival rates. A more patient-tailored approach based on predictive biomarkers could improve outcome. We aimed to predict radiotherapy (RT) response by ima...

    Authors: Elodie Melsens, Elly De Vlieghere, Benedicte Descamps, Christian Vanhove, Ken Kersemans, Filip De Vos, Ingeborg Goethals, Boudewijn Brans, Olivier De Wever, Wim Ceelen and Piet Pattyn

    Citation: Radiation Oncology 2018 13:39

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  11. Content type: Research

    Linac-based stereotactic radiosurgery or fractionated stereotactic radiotherapy (SRS/FSRT) of multiple brain lesions using volumetric modulated arc therapy (VMAT) is typically performed by a multiple-isocenter...

    Authors: Ruggero Ruggieri, Stefania Naccarato, Rosario Mazzola, Francesco Ricchetti, Stefanie Corradini, Alba Fiorentino and Filippo Alongi

    Citation: Radiation Oncology 2018 13:38

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  12. Content type: Research

    PSMA PET/CT visualises prostate cancer residual disease or recurrence at lower PSA levels compared to conventional imaging and results in a change of treatment in a remarkable high number of patients. Radiothe...

    Authors: Nina-Sophie Schmidt-Hegemann, Wolfgang Peter Fendler, Harun Ilhan, Annika Herlemann, Alexander Buchner, Christian Stief, Chukwuka Eze, Paul Rogowski, Minglun Li, Peter Bartenstein, Ute Ganswindt and Claus Belka

    Citation: Radiation Oncology 2018 13:37

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  13. Content type: Research

    68Ga-PSMA-PET-imaging has proven to be a highly sensitive and specific diagnostic element for patients with prostate cancer (PC). Does the standard clinical target volume (CTV) cover the majority of 68Ga-PSMA-PET...

    Authors: K. Schiller, M. Devecka, T. Maurer, M. Eiber, J. Gschwend, M. Schwaiger, S. E. Combs and G. Habl

    Citation: Radiation Oncology 2018 13:36

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  14. Content type: Study protocol

    Concurrent chemoradiotherapy is a standard modality for locally advanced esophageal squamous cell carcinoma (ESCC) patients. Cisplatin combined with 5-fluorouracil continuous infusion (PF) remains the standard...

    Authors: Yun Chen, Zhengfei Zhu, Weixin Zhao, Ling Li, Jinjun Ye, Chaoyang Wu, Huarong Tang, Qin Lin, Jiancheng Li, Yi Xia, Yunhai Li, Jialiang Zhou and Kuaile Zhao

    Citation: Radiation Oncology 2018 13:33

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  15. Content type: Research

    To evaluate spot-scanning proton arc therapy (SPArc) and multi-field robust optimized intensity modulated proton therapy (RO-IMPT) in treating stage III non-small-cell lung cancer (NSCLC) patients.

    Authors: Xiaoqiang Li, Peyman Kabolizadeh, Di Yan, An Qin, Jun Zhou, Ye Hong, Thomas Guerrero, Inga Grills, Craig Stevens and Xuanfeng Ding

    Citation: Radiation Oncology 2018 13:35

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  16. Content type: Research

    The purpose of this study was to evaluate the prognostic impact of Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) and Response Evaluation Criteria in Solid Tumors (RECIST) and of pre-...

    Authors: Cory Pierson, Taras Grinchak, Casey Sokolovic, Brandi Holland, Teresa Parent, Mark Bowling, Hyder Arastu, Paul Walker and Andrew Ju

    Citation: Radiation Oncology 2018 13:34

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  17. Content type: Research

    Tumor-Treating Fields (TTFields) are a novel treatment strategy for glioblastoma (GBM) that is approved for the use concomitantly to adjuvant chemotherapy. Preclinical data suggest a synergistic interaction of...

    Authors: Christoph Straube, Markus Oechsner, Severin Kampfer, Sophia Scharl, Friederike Schmidt-Graf, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:31

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  18. Content type: Research

    The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into t...

    Authors: Yushi Wakisaka, Masashi Yagi, Iori Sumida, Masaaki Takashina, Kazuhiko Ogawa and Masahiko Koizumi

    Citation: Radiation Oncology 2018 13:30

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  19. Content type: Case report

    Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment op...

    Authors: Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu and Thomas Brunner

    Citation: Radiation Oncology 2018 13:28

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  20. Content type: Research

    We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy.

    Authors: Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, Jin-Beom Chung, Keun-Yong Eom, Jae-Sung Kim, Chae-Yong Kim, Young Ho Park, Yu Jung Kim and In Ah Kim

    Citation: Radiation Oncology 2018 13:29

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  21. Content type: Research

    Volumetric-modulated Dynamic WaveArc therapy (VMDWAT) is a non-coplanar continuous volumetric modulated radiation therapy (VMAT) delivery technique. Here, we monitored mechanical errors and their impact on dos...

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Megumi Uto, Kiyonao Nakamura and Takashi Mizowaki

    Citation: Radiation Oncology 2018 13:27

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  22. Content type: Research

    Stereotactic body radiotherapy (SBRT) is an emerging treatment option for liver metastases in patients unsuitable for surgery. We investigated factors associated with clinical outcomes for liver metastases tre...

    Authors: Anand Mahadevan, Oliver Blanck, Rachelle Lanciano, Anuj Peddada, Srinath Sundararaman, David D’Ambrosio, Sanjeev Sharma, David Perry, James Kolker and Joanne Davis

    Citation: Radiation Oncology 2018 13:26

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  23. Content type: Research

    To derive and exploit the optimal prescription isodose level (PIL) in inverse optimization of volumetric modulated arc radiotherapy (VMAT) as a potential approach to dose de–escalation in stereotactic body rad...

    Authors: Mark Chan, Matthew Wong, Ronnie Leung, Steven Cheung and Oliver Blanck

    Citation: Radiation Oncology 2018 13:24

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  24. Content type: Research

    The objective of the present study was to evaluate the effectiveness of postoperative radiotherapy after breast conserving surgery (BCS) in DCIS in a large patient population treated in clinical practice.

    Authors: Stefanie Corradini, Montserrat Pazos, Stephan Schönecker, Daniel Reitz, Maximilian Niyazi, Ute Ganswindt, Simone Schrodi, Michael Braun, Martin Pölcher, Sven Mahner, Nadia Harbeck, Jutta Engel and Claus Belka

    Citation: Radiation Oncology 2018 13:25

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  25. Content type: Research

    The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who w...

    Authors: Yasuhiro Hirano, Masakatsu Onozawa, Hidehiro Hojo, Atsushi Motegi, Sadatomo Zenda, Kenji Hotta, Shunsuke Moriya, Hidenobu Tachibana, Naoki Nakamura, Takashi Kojima and Tetsuo Akimoto

    Citation: Radiation Oncology 2018 13:23

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  26. Content type: Research

    Radiation-induced parotid damage is a common complication in patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy to head and neck region, which severely reduce the life quality of those pati...

    Authors: Nan Zhou, Chen Chu, Xin Dou, Weibo Chen, Jian He, Jing Yan, Zhengyang Zhou and Xiaofeng Yang

    Citation: Radiation Oncology 2018 13:22

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  27. Content type: Research

    This study provides separate comparisons of 1 × 8 Gy to 5 × 4 Gy for metastatic epidural spinal cord compression (MESCC) in patients with poor, intermediate and favorable survival prognoses.

    Authors: Dirk Rades, Antonio J. Conde-Moreno, Jon Cacicedo, Theo Veninga, Barbara Segedin, Karmen Stanic, Volker Rudat and Steven E. Schild

    Citation: Radiation Oncology 2018 13:21

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  28. Content type: Research

    To date, patients with glioblastoma still have a bad median overall survival rate despite radiation dose-escalation and combined modality treatment. Neurocognitive decline is a crucial adverse event which may ...

    Authors: Ann-Katrin Exeli, Daniel Kellner, Lukas Exeli, Phil Steininger, Frank Wolf, Felix Sedlmayer and Heinz Deutschmann

    Citation: Radiation Oncology 2018 13:20

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  29. Content type: Research

    The purpose of the present study was to evaluate retrospectively the efficacy and safety of proton beam therapy for elderly patients (≥80 years of age) with non-small cell lung cancer.

    Authors: Takashi Ono, Tatsuya Nakamura, Hisashi Yamaguchi, Yusuke Azami, Kanako Takayama, Motohisa Suzuki, Hitoshi Wada, Yasuhiro Kikuchi, Masao Murakami and Kenji Nemoto

    Citation: Radiation Oncology 2018 13:19

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  30. Content type: Research

    For the recurrence of head and neck cancer after operation and radiotherapy, the local control of radioactive seed implantation is good, and it has a certain palliative effect. This study aims to investigate t...

    Authors: Yuliang Jiang, Zhe Ji, Fuxin Guo, Ran Peng, Haitao Sun, Jinghong Fan, Shuhua Wei, Weiyan Li, Kai Liu, Jinghua Lei and Junjie Wang

    Citation: Radiation Oncology 2018 13:18

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  31. Content type: Research

    To estimate the radiobiological parameters of three popular normal tissue complication probability (NTCP) models, which describe the dose-response relations of bladder regarding different acute urinary symptom...

    Authors: Panayiotis Mavroidis, Kevin A. Pearlstein, John Dooley, Jasmine Sun, Srinivas Saripalli, Shiva K. Das, Andrew Z. Wang and Ronald C. Chen

    Citation: Radiation Oncology 2018 13:17

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  32. Content type: Research

    Despite screening campaigns, cervical cancers remain among the most prevalent malignancies and carry significant mortality, especially in developing countries. Most studies report outcomes of patients receivin...

    Authors: Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta and Nicolas Magné

    Citation: Radiation Oncology 2018 13:16

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    The Correction to this article has been published in Radiation Oncology 2018 13:50

  33. Content type: Research

    The purpose of this study is to evaluate the tumor movement and accuracy of patient immobilization in stereotactic body radiotherapy of liver tumors with low pressure foil or abdominal compression.

    Authors: Constantin Dreher, Markus Oechsner, Michael Mayinger, Stefanie Beierl, Marciana-Nona Duma, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:15

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  34. Content type: Research

    The HyperArc VMAT (HA-VMAT) planning approach was newly developed to fulfill the demands of dose delivery for brain metastases stereotactic radiosurgery. We compared the dosimetric parameters of the HA-VMAT pl...

    Authors: Shingo Ohira, Yoshihiro Ueda, Yuichi Akino, Misaki Hashimoto, Akira Masaoka, Takero Hirata, Masayoshi Miyazaki, Masahiko Koizumi and Teruki Teshima

    Citation: Radiation Oncology 2018 13:13

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  35. Content type: Research

    Endoscopic submucosal dissection (ESD) can be used as a less invasive treatment option for superficial esophageal cancer involving the muscularis mucosae (T1a-MM) or upper third of the submucosa (T1b-SM1). Add...

    Authors: Osamu Hisano, Takeshi Nonoshita, Hidenari Hirata, Tomonari Sasaki, Hideyuki Watanabe, Hiroaki Wakiyama, Minoru Ono, Saiji Ohga and Hiroshi Honda

    Citation: Radiation Oncology 2018 13:14

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  36. Content type: Research

    Children can experience distress when undergoing radiotherapy as a reaction to being scared of and unfamiliar with the procedure. The aim was to evaluate children’s experiences and responses towards an interve...

    Authors: Gunn Engvall, Viveca Lindh, Tara Mullaney, Tufve Nyholm, Jack Lindh and Charlotte Ångström-Brännström

    Citation: Radiation Oncology 2018 13:9

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  37. Content type: Research

    Tumor immune-evasion and associated failure of immunotherapy can potentially be overcome by radiotherapy, which however also has detrimental effects on tumor-infiltrating and circulating lymphocytes (CL). We t...

    Authors: L. Basler, N. Andratschke, S. Ehrbar, M. Guckenberger and S. Tanadini-Lang

    Citation: Radiation Oncology 2018 13:10

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  38. Content type: Research

    Some Chinese patients with esophageal squamous cell carcinomaare often treated with single-agent concurrent chemoradiotherapy. However, no results have been reported from randomized controlled clinical trials ...

    Authors: Jie Li, Youling Gong, Peng Diao, Qingmei Huang, Yixue Wen, Binwei Lin, Hongwei Cai, Honggang Tian, Bing He, Lanlan Ji, Ping Guo, Jidong Miao and Xiaobo Du

    Citation: Radiation Oncology 2018 13:12

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  39. Content type: Research

    To identify optimization of dose distributions of target volumes and decrease of radiation doses to normal tissues during stereotactic body radiation therapy (SBRT) for pancreatic cancer with dose-limiting aut...

    Authors: Yangsen Cao, Xiaofei Zhu, Xiaoping Ju, Yongming Liu, Chunshan Yu, Yongjian Sun, Zhitao Dai, Xueling Guo and Huojun Zhang

    Citation: Radiation Oncology 2018 13:11

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  40. Content type: Research

    The aim of this study was to identify the long-term clinical outcome of definitive radiotherapy using three-dimensional conformal radiotherapy (3DCRT) for cervical esophageal squamous cell carcinoma (CESCC).

    Authors: Katsuyuki Sakanaka, Yuichi Ishida, Kota Fujii, Satoshi Itasaka, Shin’ichi Miyamoto, Takahiro Horimatsu, Manabu Muto and Takashi Mizowaki

    Citation: Radiation Oncology 2018 13:7

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  41. Content type: Correction

    In the original publication [1] two author names were missing the middle names. The corrected versions can be found in this Erratum.

    Authors: Andra V. Krauze, Albert Attia, Steve Braunstein, Michael Chan, Stephanie E. Combs, Rainer Fietkau, John Fiveash, John Flickinger, Anca Grosu, Steven Howard, Carsten Nieder, Maximilian Niyazi, Lindsay Rowe, Dee Dee Smart, Christina Tsien and Kevin Camphausen

    Citation: Radiation Oncology 2018 13:8

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    The original article was published in Radiation Oncology 2017 12:194

  42. Content type: Research

    The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2018 13:5

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  43. Content type: Research

    We evaluated dynamic changes in 18F–borono-L-phenylalanine (18F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neut...

    Authors: Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai and Jun Itami

    Citation: Radiation Oncology 2018 13:4

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  44. Content type: Research

    Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melano...

    Authors: Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck and David Kaul

    Citation: Radiation Oncology 2018 13:3

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  45. Content type: Research

    Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico ...

    Authors: Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus and Katia Parodi

    Citation: Radiation Oncology 2018 13:2

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  46. Content type: Research

    Patients with Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) positive lung cancer are sensitive to ALK-kinase inhibitors. TAE684 is a potent second generation ALK inhi...

    Authors: Ying Dai, Quanxiang Wei, Christian Schwager, Janina Hanne, Cheng Zhou, Klaus Herfarth, Stefan Rieken, Kenneth E. Lipson, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2018 13:1

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  47. Content type: Research

    Hypoxia-induced radioresistance constitutes a major obstacle for a curative treatment of cancer. The aim of this study was to investigate effects of photon and carbon ion irradiation in combination with inhibi...

    Authors: Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus and Amir Abdollahi

    Citation: Radiation Oncology 2017 12:208

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