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  1. Radiation caries is a complication of radiotherapy characterized by enamel erosion and dentin exposure. The mechanisms of characteristic radiation caries formation are not well-understood. The aim of this stud...

    Authors: Hui Lu, Qi Zhao, Jiang Guo, Binghui Zeng, Xinlin Yu, Dongsheng Yu and Wei Zhao

    Citation: Radiation Oncology 2019 14:5

    Content type: Research

    Published on:

  2. We performed a prospective phase II study to compare acute toxicity among five different hypofractionated schedules using proton therapy. This study was an exploratory analysis to investigate the secondary end...

    Authors: Boram Ha, Kwan Ho Cho, Kang Hyun Lee, Jae Young Joung, Yeon-Joo Kim, Sung Uk Lee, Hyunjung Kim, Yang-Gun Suh, Sung Ho Moon, Young Kyung Lim, Jong Hwi Jeong, Haksoo Kim, Weon Seo Park and Sun Ho Kim

    Citation: Radiation Oncology 2019 14:4

    Content type: Research

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  3. This study was conducted to investigate a new short-course radiotherapy regimen for patients with metastatic hormone refractory prostate cancer (HRPC) presenting with a dominant debilitating symptom.

    Authors: Jesper Carl, Dirk Rades, Claudia Doemer, Cornelia Setter, Jürgen Dunst and Niels Henrik Holländer

    Citation: Radiation Oncology 2019 14:3

    Content type: Study protocol

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  4. Advanced radiotherapy (RT) techniques allow normal tissue to be spared in patients with extremity soft tissue sarcoma (STS). This work aims to evaluate toxicity and outcome after neoadjuvant image-guided radio...

    Authors: Jan C. Peeken, Christoph Knie, Kerstin A. Kessel, Daniel Habermehl, Severin Kampfer, Hendrik Dapper, Michal Devecka, Rüdiger von Eisenhart-Rothe, Katja Specht, Wilko Weichert, Klaus Wörtler, Carolin Knebel, Jan J. Wilkens and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:2

    Content type: Research

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  5. Due to the heterogeneity of patient’s individual respiratory motion pattern in lung stereotactic body radiotherapy (SBRT), treatment planning dose assessment using a traditional four-dimensional computed tomog...

    Authors: Gang Liu, Fala Hu, Xuanfeng Ding, Xiaoqiang Li, Qihong Shao, Yuenan Wang, Jing Yang and Hong Quan

    Citation: Radiation Oncology 2019 14:1

    Content type: Research

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  6. Small cell lung cancer (SCLC) can recur in the brain after whole-brain irradiation (WBI). We documented outcomes after treatment of such recurrences and sought predictors of local control and overall survival ...

    Authors: Ryoko Suzuki, Xiong Wei, Pamela K. Allen, James W. Welsh, James D. Cox, Ritsuko Komaki and Steven H. Lin

    Citation: Radiation Oncology 2018 13:258

    Content type: Research

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  7. Local progression-free survival (LPFS = stable or improved motor function/resolution of paraplegia during RT without in-field recurrence following RT) is important when treating metastatic spinal cord compress...

    Authors: Dirk Rades, Antonio J. Conde-Moreno, Jon Cacicedo, Theo Veninga, Barbara Segedin, Karmen Stanic and Steven E. Schild

    Citation: Radiation Oncology 2018 13:257

    Content type: Research

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  8. PRIMO is a dose verification system based on the general-purpose Monte Carlo radiation transport code penelope, which implements an accurate physics model of the interaction cross sections and the radiation trans...

    Authors: Miguel Rodriguez, Josep Sempau, Christian Bäumer, Beate Timmermann and Lorenzo Brualla

    Citation: Radiation Oncology 2018 13:256

    Content type: Research

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  9. Elective use of radiation therapy to treat regionally involved lymph nodes (LNs) after radical surgery for esophageal squamous cell carcinoma (ESCC) is controversial. We studied metastasis patterns through a p...

    Authors: Xiaofei Zhang, Xi Yang, Jianjiao Ni, Yida Li, Liqing Zou, Li Chu, Xiao Chu, Fan Xia and Zhengfei Zhu

    Citation: Radiation Oncology 2018 13:255

    Content type: Research

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  10. This study aimed to evaluate the inter-fraction set-up error and intra-fraction motion during reverse semi-decubitus (RSD) breast radiotherapy, and to determine a planning target volume (PTV) margin.

    Authors: Jie Lee, Shih-Hua Liu, Jhen-Bin Lin, Meng-Hao Wu, Chieh-Ju Wu, Hung-Chi Tai, Shih-Ming Hsu, Yin-Ju Chen, Jo-Chiao Tai and Yu-Jen Chen

    Citation: Radiation Oncology 2018 13:254

    Content type: Research

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  11. Although stereotactic radiotherapy (SRT) for vestibular schwannoma has demonstrated excellent local control rates, hearing deterioration is often reported after treatment. We therefore wished to assess the cha...

    Authors: A. van Linge, R. van Os, N. Hoekstra, B. Heijmen, L. Stienstra, A. Dallenga, J. Wolbers and A. Mendez Romero

    Citation: Radiation Oncology 2018 13:253

    Content type: Research

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  12. Stereotactic radiosurgery (SRS) has emerged as a common adjuvant modality used with surgery for resectable brain metastases (BMs). However, the optimal sequence of the multi-modality therapy has not been estab...

    Authors: Wei X. Huff, Namita Agrawal, Scott Shapiro, James Miller, Charles Kulwin, Mitesh Shah, Jesse J. Savage, Troy Payner, Alexander Vortmeyer, Gordon Watson and Mahua Dey

    Citation: Radiation Oncology 2018 13:252

    Content type: Study protocol

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  13. The dismal overall survival (OS) prognosis of glioblastoma, even after trimodal therapy, can be attributed mainly to the frequent incidence of intracranial relapse (ICR), which tends to present as an in-field ...

    Authors: Sebastian Zschaeck, Peter Wust, Reinhold Graf, Martin Misch, Julia Onken, Pirus Ghadjar, Harun Badakhshi, Julian Florange, Volker Budach and David Kaul

    Citation: Radiation Oncology 2018 13:251

    Content type: Research

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  14. The role of the dose escalation strategy in brain radiotherapy for small cell lung cancer (SCLC) patients with brain metastases (BMs) has not been identified. This study aims to determine whether an additional...

    Authors: Han Sun, Liming Xu, Youyou Wang, Junhua Zhao, Kunpeng Xu, Jing Qi, Zhiyong Yuan, Lujun Zhao and Ping Wang

    Citation: Radiation Oncology 2018 13:250

    Content type: Research

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  15. Concurrent chemoradiotherapy (CCRT) is effective in the treatment of locally advanced cervical squamous cell carcinoma (SCC). However, whether treatment outcomes of cervical adenocarcinoma are equivalent to SC...

    Authors: Ke Hu, Weiping Wang, Xiaoliang Liu, Qingyu Meng and Fuquan Zhang

    Citation: Radiation Oncology 2018 13:249

    Content type: Research

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  16. To report our experience in planning and delivering total marrow irradiation (TMI) and total marrow and lymphatic irradiation (TMLI) in patients with hematologic malignancies.

    Authors: Zhirong Bao, Hongli Zhao, Dajiang Wang, Jian Gong, Yahua Zhong, Yu Xiong, Di Deng, Conghua Xie, An Liu, Xiaoyong Wang and Hui Liu

    Citation: Radiation Oncology 2018 13:248

    Content type: Research

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  17. The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and af...

    Authors: Yu Yang Soon, Huili Zheng, Shaun Zhirui Ho, Wee Yao Koh, Cheng Nang Leong, Jeremy Chee Seong Tey, Balamurugan Vellayappan, Swee Peng Yap, Ivan Weng Keong Tham and Kam Weng Fong

    Citation: Radiation Oncology 2018 13:247

    Content type: Research

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  18. The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with e...

    Authors: Gen Suzuki, Hideya Yamazaki, Norihiro Aibe, Koji Masui, Naomi Sasaki, Daisuke Shimizu, Takuya Kimoto, Atsushi Shiozaki, Osamu Dohi, Hitoshi Fujiwara, Takeshi Ishikawa, Hirotaka Konishi, Yuji Naito, Eigo Otsuji and Kei Yamada

    Citation: Radiation Oncology 2018 13:246

    Content type: Research

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  19. Oesophageal cancer with airway invasion presents a challenge for therapy and often has serious complications. We analysed the clinical outcomes of radiation therapy (RT) in patients with clinical T4b oesophage...

    Authors: Hakyoung Kim, Dongryul Oh, Yong Chan Ahn, Keunchil Park, Myung-Ju Ahn, Se-Hoon Lee, Jong-Mu Sun, Young Mog Shim, Jae Ill Zo, Yong Soo Choi, Hong Kwan Kim and Jong Ho Cho

    Citation: Radiation Oncology 2018 13:245

    Content type: Research

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  20. Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, ...

    Authors: Verónica García-Vázquez, Begoña Sesé-Lucio, Felipe A. Calvo, Juan J. Vaquero, Manuel Desco and Javier Pascau

    Citation: Radiation Oncology 2018 13:243

    Content type: Research

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  21. Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers...

    Authors: Marc Ziegler, Tobias Brandt, Sebastian Lettmaier, Rainer Fietkau and Christoph Bert

    Citation: Radiation Oncology 2018 13:242

    Content type: Research

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  22. Automatic multi-criteria optimization is necessary for intensity modulated radiation therapy (IMRT) because of low planning efficiency and large plan quality uncertainty in current clinical practice. Most stud...

    Authors: Yanhua Mai, Fantu Kong, Yiwei Yang, Linghong Zhou, Yongbao Li and Ting Song

    Citation: Radiation Oncology 2018 13:241

    Content type: Research

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  23. Advanced clinical applications, such as dose accumulation and adaptive radiation therapy, require deformable image registration (DIR) algorithms capable of voxel-wise accurate mapping of treatment dose or func...

    Authors: An Qin, Dan Ionascu, Jian Liang, Xiao Han, Nicolette O’Connell and Di Yan

    Citation: Radiation Oncology 2018 13:240

    Content type: Research

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  24. Peer review systems within radiation oncology are important to ensure quality radiation care. Several individualized methods for radiation oncology peer review have been described. However, despite the importa...

    Authors: Ashley A. Albert, William N. Duggar, Rahul P. Bhandari, Toms Vengaloor Thomas, Satyaseelan Packianathan, Robert M. Allbright, Madhava R. Kanakamedala, Divyang Mehta, Chunli Claus Yang and Srinivasan Vijayakumar

    Citation: Radiation Oncology 2018 13:239

    Content type: Research

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  25. Volumetric shrinkage of normal tissues such as salivary glands, kidneys, hippocampus are observed after radiotherapy. We aimed to assess the alterations in pancreatic volume of patients who received abdominal ...

    Authors: Cengiz Gemici, Gokhan Yaprak, Sevim Ozdemir, Tamer Baysal, Ozgur Ozan Seseogullari and Hazan Ozyurt

    Citation: Radiation Oncology 2018 13:238

    Content type: Research

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  26. Neoadjuvant radio- or chemoradiation (nIRT) therapy is the standard treatment for loco-regional advanced rectal cancer patients of the lower or middle third. Currently, intensity modulated radiation therapy (I...

    Authors: Hendrik Dapper, Iván Rodríguez, Stefan Münch, Jan C. Peeken, Kai Borm, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:237

    Content type: Research

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  27. To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advance...

    Authors: Pei-Chieh Yu, Ching-Jung Wu, Hsin-Hua Nien, Louis Tak Lui, Suzun Shaw and Yu-Lun Tsai

    Citation: Radiation Oncology 2018 13:236

    Content type: Research

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  28. To compare the clinical outcome in prostate cancer patients treated with radiotherapy using two forms of image guidance: bone-based (BB) or fiducial-based (FB).

    Authors: Aleksandra Napieralska, Wojciech Majewski, Roland Kulik, Grzegorz Głowacki and Leszek Miszczyk

    Citation: Radiation Oncology 2018 13:235

    Content type: Research

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  29. The aim of this study was to evaluate long-term efficacy and survival prognostic factors of stereotactic body radiation therapy (SBRT) for un-resectable liver metastases in patients enrolled in a prospective p...

    Authors: Marta Scorsetti, Tiziana Comito, Elena Clerici, Ciro Franzese, Angelo Tozzi, Cristina Iftode, Lucia Di Brina, Pierina Navarria, Pietro Mancosu, Giacomo Reggiori, Antonella Fogliata, Stefano Tomatis, Guido Torzilli and Luca Cozzi

    Citation: Radiation Oncology 2018 13:234

    Content type: Research

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  30. The purpose of this study is to compare the efficacy and safety of concurrent chemoradiotherapy (CCRT) versus chemotherapy alone for patients with stage IV esophageal squamous cell carcinoma (ESCC).

    Authors: Jiahua Lyu, Tao Li, Qifeng Wang, Fang Li, Peng Diao, Li Liu, Churong Li and Jinyi Lang

    Citation: Radiation Oncology 2018 13:233

    Content type: Research

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  31. The usefulness of particle therapy for skull base chordoma has not been established. The aim of this retrospective study was to analyse the treatment outcomes of proton therapy (PT) and carbon ion therapy (CIT...

    Authors: Masaru Takagi, Yusuke Demizu, Fumiko Nagano, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Masayuki Mima, Yasue Niwa, Kuniaki Katsui, Masaki Suga, Tomohiro Yamashita, Takashi Akagi, Koh-ichi Sakata, Nobukazu Fuwa and Tomoaki Okimoto

    Citation: Radiation Oncology 2018 13:232

    Content type: Research

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  32. Tangent-based intensity modulated radiation therapy (TIMRT) is a common adjuvant radiotherapy strategy for breast cancer patients. This study compared the dosimetric characteristics of tangent-based volumetric...

    Authors: Pei-Chieh Yu, Ching-Jung Wu, Yu-Lun Tsai, Suzun Shaw, Shih-Yu Sung, Louis Tak Lui and Hsin-Hua Nien

    Citation: Radiation Oncology 2018 13:231

    Content type: Research

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  33. To evaluate the treatment outcome and prostate-specific antigen (PSA) change after stereotactic body radiotherapy (SBRT) for localized prostate cancer.

    Authors: Younghee Park, Hae Jin Park, Won Il Jang, Bae Kwon Jeong, Hun-Jung Kim and Ah Ram Chang

    Citation: Radiation Oncology 2018 13:230

    Content type: Research

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  34. A new strategy is introduced combining the use of Multi-Criteria Optimization-based Trade-Off Exploration (TO) and RapidPlan™ (RP) for the selection of optimisation parameters that improve the trade-off betwee...

    Authors: Eliane Miguel-Chumacero, Garry Currie, Abigail Johnston and Suzanne Currie

    Citation: Radiation Oncology 2018 13:229

    Content type: Research

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  35. Neoadjuvant radio(chemo)therapy of non-metastasized, borderline resectable or unresectable locally advanced pancreatic cancer is complex and prone to cause side-effects, e.g., in gastrointestinal organs. Inten...

    Authors: Sarah Stefanowicz, Kristin Stützer, Sebastian Zschaeck, Annika Jakobi and Esther G. C. Troost

    Citation: Radiation Oncology 2018 13:228

    Content type: Research

    Published on:

  36. The ano-inguinal lymphatic drainage (AILD) is located in the subcutaneous adipose tissue of the proximal medial thigh. Currently, there are no recommendations for an inclusion of the ‘true’ AILD in the clinica...

    Authors: Hendrik Dapper, Markus Oechsner, Christoph Hirche, Stefan Münch, Christina Sauter, Kai Borm, Jan C. Peeken, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:227

    Content type: Research

    Published on:

  37. Following publication of the original article [1], the authors reported that one of the authors’ names was processed incorrectly.

    Authors: J. Krayenbuehl, M. Zamburlini, S. Ghandour, M. Pachoud, S. Tanadini-Lang, J. Tol, M. Guckenberger and W. F. A. R. Verbakel

    Citation: Radiation Oncology 2018 13:225

    Content type: Correction

    Published on:

    The original article was published in Radiation Oncology 2018 13:170

  38. Patients with recurrent retroperitoneal and pelvic region tumors often require multimodal therapies. Intraoperative radiation therapy (IORT) can deliver high-dose radiation to tumor beds, even if first-line ex...

    Authors: Tharcisio Machado Coelho, Ricardo César Fogaroli, Antonio Cassio Assis Pellizzon, Douglas Guedes De Castro, Guilherme Rocha Melo Gondim, Maria Leticia Gobo Silva, Michael Jenwei Chen and Henderson Ramos

    Citation: Radiation Oncology 2018 13:224

    Content type: Research

    Published on:

  39. Currently, the standard treatment for locally advanced cervical cancer patients is concurrent chemoradiotherapy. Here we aim to evaluate therapeutic efficacy, treatment failure, toxicity and prognostic factors...

    Authors: Qingyu Meng, Weiping Wang, Xiaoliang Liu, Xiaorong Hou, Xin Lian, Shuai Sun, Junfang Yan, Zhikai Liu, Zheng Miao, Ke Hu and Fuquan Zhang

    Citation: Radiation Oncology 2018 13:223

    Content type: Research

    Published on:

  40. The dosimetric leaf gap (DLG) and multileaf collimator (MLC) transmission are two important systematic parameters used to model the rounded MLC leaf ends effect when commissioning an Eclipse treatment planning...

    Authors: Chih-Yuan Lin, An-Cheng Shiau, Jin-Huei Ji, Chia-Jung Lee, Ti-Hao Wang, Shu-Hui Hsu and Ji-An Liang

    Citation: Radiation Oncology 2018 13:222

    Content type: Research

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  41. It has been reported that proximity of the tumor to the optic disc and macula, and radiation dose to the critical structures are substantial risk factors for vision loss following plaque brachytherapy. However...

    Authors: Yongsook C. Lee, Shih-Chi Lin and Yongbok Kim

    Citation: Radiation Oncology 2018 13:221

    Content type: Research

    Published on:

  42. Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently availab...

    Authors: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio and Panu M. Jaakkola

    Citation: Radiation Oncology 2018 13:220

    Content type: Research

    Published on:

  43. To propose an easily applicable segmentation method (perPET-RT) for delineation of tumour volume during radiotherapy on interim fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomogr...

    Authors: J. Ganem, S. Thureau, I. Gardin, R. Modzelewski, S. Hapdey and P. Vera

    Citation: Radiation Oncology 2018 13:219

    Content type: Research

    Published on:

  44. This study was performed to evaluate skin toxicity during modern three-dimensional conformal radiotherapy (3D-CRT) and to evaluate the importance of dose distribution and patient related factors.

    Authors: Kai J. Borm, Maximilian Loos, Markus Oechsner, Michael C. Mayinger, Daniela Paepke, Marion B. Kiechle, Stephanie E. Combs and Marciana N. Duma

    Citation: Radiation Oncology 2018 13:218

    Content type: Research

    Published on:

  45. A high neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and together with the platelet-to-lymphocyte ratio (PLR) is associated with worse outcomes in several solid tumors. We investiga...

    Authors: Beat Bojaxhiu, Arnoud J. Templeton, Olgun Elicin, Mohamed Shelan, Kathrin Zaugg, Marc Walser, Roland Giger, Daniel M. Aebersold and Alan Dal Pra

    Citation: Radiation Oncology 2018 13:216

    Content type: Research

    Published on:

  46. Cancer cachexia is a prevalent symptom of head and neck neoplasms. The reduction in skeletal muscle mass is one of the main characteristics which can lead to poor physical functioning. The purposes of this pil...

    Authors: Manuel Grote, Cornelius Maihöfer, Martin Weigl, Patricia Davies-Knorr and Claus Belka

    Citation: Radiation Oncology 2018 13:215

    Content type: Research

    Published on:

  47. Dose escalation of conventionally fractionated radiation therapy (CFRT) above 45–54 Gy has an unclear survival benefit. Prior National Cancer Database (NCDB) analyses have shown improved overall survival with ...

    Authors: Sung Jun Ma, Kavitha M. Prezzano, Gregory M. Hermann and Anurag K. Singh

    Citation: Radiation Oncology 2018 13:214

    Content type: Research

    Published on:

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