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  1. To evaluate the dosimetric and biological benefits of the fixed-jaw (FJ) intensity-modulated radiation therapy (IMRT) technique for patients with T-shaped esophageal cancer.

    Authors: Hua Chen, Ying Huang, Hao Wang, Yan Shao, Ning J. Yue, Hengle Gu, Yanhua Duan, Aihui Feng and Zhiyong Xu
    Citation: Radiation Oncology 2021 16:158
  2. To investigate the treatment outcomes of passive scattering proton beam therapy using stereotactic ablative radiotherapy (SABR) or hypofractionated radiation therapy (RT) for inoperable patients or those who r...

    Authors: Unurjargal Bayasgalan, Sung Ho Moon, Jong Hwi Jeong, Tae Hyun Kim, Kwan Ho Cho and Yang-Gun Suh
    Citation: Radiation Oncology 2021 16:155
  3. Patient-specific dose prediction improves the efficiency and quality of radiation treatment planning and reduces the time required to find the optimal plan. In this study, a patient-specific dose prediction mo...

    Authors: Sang Hee Ahn, EunSook Kim, Chankyu Kim, Wonjoong Cheon, Myeongsoo Kim, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Dae Yong Kim and Jong Hwi Jeong
    Citation: Radiation Oncology 2021 16:154
  4. Common symptoms of oesophageal cancer are dysphagia, pain, and bleeding. These symptoms can be relieved with palliative radiotherapy. The aim of this study was to analyse the outcome of two different palliativ...

    Authors: Halla Sif Ólafsdóttir, Fredrik Klevebro, Nelson Ndegwa and Gabriella Alexandersson von Döbeln
    Citation: Radiation Oncology 2021 16:153
  5. Treatment-related white blood cell (WBC) toxicity has been associated with an inferior prognosis in different malignancies, including anal cancer. The aim of the present study was to investigate predictors of ...

    Authors: Martin P. Nilsson, Anders Johnsson and Jonas Scherman
    Citation: Radiation Oncology 2021 16:152
  6. Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as 68 Ga-DOTATATE have been recently shown to aid in the imaging and identification of me...

    Authors: Emily S. Kowalski, Rahul Khairnar, Anton A. Gryaznov, Vivek Kesari, Antony Koroulakis, Prashant Raghavan, Wengen Chen, Graeme Woodworth and Mark Mishra
    Citation: Radiation Oncology 2021 16:151
  7. Inter-modality image registration between computed tomography (CT) and magnetic resonance (MR) images is associated with systematic uncertainties and the magnitude of these uncertainties is not well documented...

    Authors: Emilia Persson, Sevgi Emin, Jonas Scherman, Christian Jamtheim Gustafsson, Patrik Brynolfsson, Sofie Ceberg, Adalsteinn Gunnlaugsson and Lars E. Olsson
    Citation: Radiation Oncology 2021 16:150
  8. To compare the clinical outcomes of stereotactic body radiation therapy (SBRT) and fractionated radiation therapy (FRT) for primary liver cancer with portal vein tumor thrombus (PVTT).

    Authors: Sujing Zhang, Li He, Changwen Bo, Shufang Yang, Yonghui An, Na Li, Yingchun Zhao, Liping Zhao, Wenhua Ma and Zheng Zheng
    Citation: Radiation Oncology 2021 16:149
  9. The purpose of this study was to analyze the treatment efficacy and safety of stereotactic ablative body radiotherapy (SABR) boost for cervical cancer patients not amenable to brachytherapy.

    Authors: Tae Hoon Lee, Changhoon Song, In Ah Kim, Jae-Sung Kim, Yong Beom Kim, Kidong Kim, Jae Hong No, Dong Hoon Suh, Jin-Beom Chung and Keun-Yong Eom
    Citation: Radiation Oncology 2021 16:148
  10. Image guidance in radiation oncology has resulted in significant improvements in the accuracy and precision of radiation therapy (RT). Recently, the resolution and quality of cone beam computed tomography (CBC...

    Authors: Whitney Sumner, Sangwoo S. Kim, Lucas Vitzthum, Kevin Moore, Todd Atwood, James Murphy, Sayuri Miyauchi, Joseph A. Califano, Loren K. Mell, Arno J. Mundt and Andrew B. Sharabi
    Citation: Radiation Oncology 2021 16:147
  11. A range pull-back device, such as a machine-related range shifter (MRS) or a universal patient-related range shifter (UPRS), is needed in pencil beam scanning technique to treat shallow tumors.

    Authors: Haibo Lin, Chengyu Shi, Sheng Huang, Jiajian Shen, Minglei Kang, Qing Chen, Huifang Zhai, James McDonough, Zelig Tochner, Curtiland Deville, Charles B. Simone II and Stefan Both
    Citation: Radiation Oncology 2021 16:146
  12. Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different ada...

    Authors: Miriam Eckl, Gustavo R. Sarria, Sandra Springer, Marvin Willam, Arne M. Ruder, Volker Steil, Michael Ehmann, Frederik Wenz and Jens Fleckenstein
    Citation: Radiation Oncology 2021 16:145
  13. To use cone-beam computed tomography (CBCT) imaging to determine the impacts of patient characteristics on the magnitude of geometric setup errors and obtain patient-specific planning target volume (PTV) margi...

    Authors: Jurui Luo, Zhihai Yin, Zhen Zhang, Xiaomao Guo, Xiaoli Yu and Juanqi Wang
    Citation: Radiation Oncology 2021 16:143
  14. Quality assurance (QA) of treatment plans in clinical trials improves protocol compliance and patient outcomes. Retrospective use of knowledge-based-planning (KBP) in clinical trials has demonstrated improved ...

    Authors: Nicholas Hardcastle, Olivia Cook, Xenia Ray, Alisha Moore, Kevin L. Moore, David Pryor, Alana Rossi, Farshad Foroudi, Tomas Kron and Shankar Siva
    Citation: Radiation Oncology 2021 16:142
  15. Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of majo...

    Authors: Minli Niu, Stephanie E. Combs, Annett Linge, Mechthild Krause, Michael Baumann, Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu and Gabriele Multhoff
    Citation: Radiation Oncology 2021 16:141
  16. The risk for radiation necrosis is lower in fractionated stereotactic radiotherapy (SRT) than in conventional radiotherapy, and 13-fraction SRT is our method of choice for the treatment of brain metastases ≥ a...

    Authors: Megumi Uto, Kengo Ogura, Tomohiro Katagiri, Keiichi Takehana and Takashi Mizowaki
    Citation: Radiation Oncology 2021 16:140
  17. Mega-voltage fan-beam Computed Tomography (MV-FBCT) holds potential in accurate determination of relative electron density (RED) and proton stopping power ratio (SPR) but is not widely available.

    Authors: Hao Gong, Shengzhen Tao, Justin D. Gagneur, Wei Liu, Jiajian Shen, Cynthia H. McCollough, Yanle Hu and Shuai Leng
    Citation: Radiation Oncology 2021 16:139
  18. The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide ...

    Authors: Qing-Qing Xu, Yan-Zhen Lai, Zi-Lu Huang, Zi-Yi Zeng, Ya-Ni Zhang, Rui-Yao Ou, Wen-Min Wu, Lei Chen and Li-Xia Lu
    Citation: Radiation Oncology 2021 16:138
  19. Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuxim...

    Authors: Raik Schneider, Günther Gademann, Hans-Joachim Ochel, Karsten Neumann, Burkhard Jandrig, Peter Hass, Mathias Walke, Martin Schostak, Thomas Brunner and Frank Christoph
    Citation: Radiation Oncology 2021 16:137
  20. Online adaptive radiotherapy has the potential to reduce toxicity for patients treated for rectal cancer because smaller planning target volumes (PTV) margins around the entire clinical target volume (CTV) are...

    Authors: Rianne de Jong, Jorrit Visser, Niek van Wieringen, Jan Wiersma, Debby Geijsen and Arjan Bel
    Citation: Radiation Oncology 2021 16:136
  21. This study aimed to (1) develop a fully residual deep convolutional neural network (CNN)-based segmentation software for computed tomography image segmentation of the male pelvic region and (2) demonstrate its...

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Pascal Baillehache, Yusuke Fujimoto, Shota Nakagawa, Yusuke Saruya, Tatsumasa Kabasawa and Takashi Mizowaki
    Citation: Radiation Oncology 2021 16:135
  22. Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the corr...

    Authors: Zhengwen Shen, Xia Tan, Shi Li, Xiumei Tian, Huanli Luo, Ying Wang and Fu Jin
    Citation: Radiation Oncology 2021 16:134
  23. The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac)...

    Authors: Vanessa Da Silva Mendes, Lukas Nierer, Minglun Li, Stefanie Corradini, Michael Reiner, Florian Kamp, Maximilian Niyazi, Christopher Kurz, Guillaume Landry and Claus Belka
    Citation: Radiation Oncology 2021 16:133
  24. Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in ...

    Authors: Xin Xu, Zhi-Yong Sun, Hua-Wei Wu, Chen-Peng Zhang, Bin Hu, Ling Rong, Hai-Yan Chen, Hua-Ying Xie, Yu-Ming Wang, Hai-Ping Lin, Yong-Rui Bai, Qing Ye and Xiu-Mei Ma
    Citation: Radiation Oncology 2021 16:132
  25. Symptomatic radiation pneumonitis (RP) may be a serious complication after thoracic radiation therapy (RT) for non-small cell lung cancer (NSCLC). This prospective observational study sought to evaluate the ut...

    Authors: Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takács-Szabó, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bøgsted, Tine McCulloch, Jens Brøndum Frøkjær, Ursula Gerda Falkmer and Oluf Dimitri Røe
    Citation: Radiation Oncology 2021 16:131
  26. Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which...

    Authors: Szu Ching Khoo, Syed Nabil, Azizah Ahmad Fauzi, Siti Salmiah Mohd Yunus, Wei Cheong Ngeow and Roszalina Ramli
    Citation: Radiation Oncology 2021 16:130
  27. Pathological complete response (pathCR) in rectal cancer is beneficial, as up to 75% of patients do not experience regrowth of the primary tumour, but it is poorly understood. We hypothesised that the changes ...

    Authors: Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, Ian Geh, João D. Barros-Silva and Andrew D. Beggs
    Citation: Radiation Oncology 2021 16:129
  28. To map anatomic patterns of para-aortic lymph node (PALN) recurrence in cervical cancer patients and validate currently available guidelines on PA clinical target volumes (CTV).

    Authors: Bong Kyung Bae, Shin-Hyung Park, Shin Young Jeong, Gun Oh Chong, Mi Young Kim and Jae-Chul Kim
    Citation: Radiation Oncology 2021 16:128
  29. We read with great interest the recent review, entitled “Current status and recent advances in resection cavity irradiation of brain metastases”. It is a comprehensive summary of currently available techniques...

    Authors: Gustavo R. Sarria, Christopher P. Cifarelli, Henning Kahl and Frank A. Giordano
    Citation: Radiation Oncology 2021 16:127

    The original article was published in Radiation Oncology 2021 16:73

  30. Historically, IBD has been thought to increase the underlying risk of radiation related toxicity in the treatment of prostate cancer. In the modern era, contemporary radiation planning and delivery may mitigat...

    Authors: Jonathan W. Lischalk, Seth Blacksburg, Christopher Mendez, Michael Repka, Astrid Sanchez, Todd Carpenter, Matthew Witten, Jules E. Garbus, Andrew Evans, Sean P. Collins, Aaron Katz and Jonathan Haas
    Citation: Radiation Oncology 2021 16:126
  31. The aim of this work was to investigate the outcome of metastasis-directed radiotherapy (MDT) in prostate cancer patients with bone metastases following current ESTRO/EORTC subclassifications for oligometastat...

    Authors: Paul Rogowski, Christian Trapp, Rieke von Bestenbostel, Nina-Sophie Schmidt-Hegemann, Run Shi, Harun Ilhan, Alexander Kretschmer, Christian Stief, Ute Ganswindt, Claus Belka and Minglun Li
    Citation: Radiation Oncology 2021 16:125
  32. Any Monte Carlo simulation of dose delivery using medical accelerator-generated megavolt photon beams begins by simulating electrons of the primary electron beam interacting with a target. Because the electron...

    Authors: Zbisław Tabor, Damian Kabat and Michael P. R. Waligórski
    Citation: Radiation Oncology 2021 16:124

    The Correction to this article has been published in Radiation Oncology 2022 17:44

  33. Adjuvant hysterectomy following chemoradiation for bulky, early stage cervical cancer has been shown to decrease local relapse rate. The objective of this study is to compare complications and recurrences betw...

    Authors: Heather Miller, Koji Matsuo, Lynda D. Roman, Annie A. Yessaian, Huyen Q. Pham, Marianne Hom, Antonio Castaneda, Anthony Pham, Omar Ragab, Laila Muderspach, Marcia Ciccone and Laurie L. Brunette
    Citation: Radiation Oncology 2021 16:123

    The Correction to this article has been published in Radiation Oncology 2021 16:162

  34. We evaluated the efficiency and toxicity of stereotactic hypofractionated boost in combination with conventionally fractionated radiotherapy in the treatment of advanced floor of the mouth cancer.

    Authors: Tomáš Blažek, Zuzana Zděblová Čermáková, Lukáš Knybel, Pavel Hurník, Jan Štembírek, Kamila Resová, Tereza Paračková, Martin Formánek, Jakub Cvek and Renata Soumarová
    Citation: Radiation Oncology 2021 16:122
  35. Screening and management of venous thromboembolism (VTE) after surgery is important in preventing sublethal VTE. However, the risk factors for VTE during interstitial brachytherapy (ISBT) remain unknown, and a...

    Authors: Keiko Nemoto Murofushi, Tetsuya Tomita, Kayoko Ohnishi, Kei Nakai, Azusa Akiyama, Tsukasa Saida, Toshiyuki Okumura, Katsuyuki Karasawa, Toyomi Satoh and Hideyuki Sakurai
    Citation: Radiation Oncology 2021 16:121
  36. To establish regression models of physical and equivalent dose in 2 Gy per fraction (EQD2) plan parameters of two kinds of hybrid planning for stage III NSCLC.

    Authors: Hao Wang, Yongkang Zhou, Wutian Gan, Hua Chen, Ying Huang, Yanhua Duan, Aihui Feng, Yan Shao, Hengle Gu, Qing Kong and Zhiyong Xu
    Citation: Radiation Oncology 2021 16:119
  37. Cranial nerve (CN) palsy due to cancer involvement has been considered as an unfavorable prognostic factor for patients with nasopharyngeal carcinoma (NPC). We assessed the role of IMRT based treatment on the ...

    Authors: Jian Zang, Yan Li, Shanquan Luo, Jianhua Wang, Bingxin Hou, Min Yao, Lina Zhao and Mei Shi
    Citation: Radiation Oncology 2021 16:118
  38. The purpose of this study is to comprehensively evaluate the suitability of Gafchromic EBT3 and EBT-XD film for dosimetric quality assurance in 0.35 T MR-guided radiotherapy.

    Authors: Ilma Xhaferllari, Joshua P. Kim, Ruchira Liyanage, Chang Liu, Dongsu Du, Anthony Doemer, Indrin J. Chetty and Ning Wen
    Citation: Radiation Oncology 2021 16:117
  39. Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding recurrence patterns after additive radiotherapy is scarce but could improve radiotherapy p...

    Authors: Elgin Hoffmann, Kerstin Clasen, Bettina Frey, Jakob Ehlers, Felix Behling, Marco Skardelly, Benjamin Bender, Jens Schittenhelm, Matthias Reimold, Ghazaleh Tabatabai, Daniel Zips, Franziska Eckert and Frank Paulsen
    Citation: Radiation Oncology 2021 16:116
  40. 125I seed implantation has been found to show good therapeutic effects on tumors. Recent studies showed that three-dimensional (3D) print template-assisted 125I seed implantation can optimize radiation dose distr...

    Authors: Enli Chen, Yuwei Zhang, Hongtao Zhang, Chenfei Jia, Yansong Liang and Juan Wang
    Citation: Radiation Oncology 2021 16:115
  41. Advances in imaging, biomaterials and precision radiotherapy provide new opportunities to salvage locally recurrent prostate cancer (PC). This study evaluates the efficacy and safety of re-irradiation using st...

    Authors: Ron Lewin, Uri Amit, Menachem Laufer, Raanan Berger, Zohar Dotan, Liran Domachevsky, Tima Davidson, Orith Portnoy, Lev Tsvang, Maoz Ben-Ayun, Ilana Weiss and Zvi Symon
    Citation: Radiation Oncology 2021 16:114
  42. The hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.

    Authors: Clara Le Fèvre, Xue Cheng, Marie-Pierre Loit, Audrey Keller, Hélène Cebula, Delphine Antoni, Alicia Thiery, Jean-Marc Constans, François Proust and Georges Noel
    Citation: Radiation Oncology 2021 16:112
  43. Daily anatomical deviations may distort the dose distribution in carbon ion radiotherapy (CIRT), which may cause treatment failure. Therefore, this study aimed to perform re-planning to maintain the dose cover...

    Authors: Yang Li, Yoshiki Kubota, Masahiko Okamoto, Shintaro Shiba, Shohei Okazaki, Toshiaki Matsui, Mutsumi Tashiro, Takashi Nakano and Tatsuya Ohno
    Citation: Radiation Oncology 2021 16:111
  44. To investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of vari...

    Authors: Luca Cozzi, Sushil Beriwal, Esa Kuusela, Supriya Chopra, Hester Burger, Nanette Joubert, Antonella Fogliata, Jai Prakash Agarwal and Pat Kupelian
    Citation: Radiation Oncology 2021 16:110
  45. The present study aimed to propose a new foetal shielding device for pregnant cancer patients to reduce the foetal dose associated with treatment techniques using multiple gantry angles, such as intensity-modu...

    Authors: Seonghee Kang, Kyeong-Hyeon Kim, Sang-Won Kang, Dong-Seok Shin, Seungwan Lee and Jin-Beom Chung
    Citation: Radiation Oncology 2021 16:109
  46. The purpose of this study is to evaluate inter- and intra-fraction organ motion as well as to quantify clinical target volume (CTV) to planning target volume (PTV) margins to be adopted in the stereotactic tre...

    Authors: Annarita Perillo, Valeria Landoni, Alessia Farneti and Giuseppe Sanguineti
    Citation: Radiation Oncology 2021 16:106

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