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  1. Neoadjuvant external-beam radiotherapy (EBRT) with concomitant chemotherapy is the current standard-of-care for locally-advanced rectal cancer. Intraoperative radiotherapy (IORT) is to date only recommended fo...

    Authors: Sergey Potemin, Jens Kübler, Ivan Uvarov, Frederik Wenz and Frank Giordano

    Citation: Radiation Oncology 2020 15:11

    Content type: Research

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  2. Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, prolifera...

    Authors: Yang Tang, Li Yang, Wan Qin, Min’ Xiao Yi, Bo Liu and Xiang’Lin Yuan

    Citation: Radiation Oncology 2020 15:9

    Content type: Research

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  3. Definitive chemoradiotherapy (dCRT) is a standard treatment for patients with locally advanced head and neck cancer. There is a clinical need for a stratification of this prognostically heterogeneous group of ...

    Authors: Lars Schüttrumpf, Sebastian Marschner, Katrin Scheu, Julia Hess, Sibylle Rietzler, Axel Walch, Philipp Baumeister, Thomas Kirchner, Ute Ganswindt, Horst Zitzelsberger, Claus Belka and Cornelius Maihoefer

    Citation: Radiation Oncology 2020 15:7

    Content type: Research

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  4. To determine the relative biological effectiveness (RBE) and α/β-values after fractionated carbon ion irradiations of the rat spinal cord with varying linear energy transfer (LET) to benchmark RBE-model calculati...

    Authors: Maria Saager, Christin Glowa, Peter Peschke, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger

    Citation: Radiation Oncology 2020 15:6

    Content type: Research

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  5. mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tum...

    Authors: Kathrin Gennen, Lukas Käsmann, Julian Taugner, Chukwuka Eze, Monika Karin, Olarn Roengvoraphoj, Jens Neumann, Amanda Tufman, Michael Orth, Simone Reu, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:5

    Content type: Research

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  6. Intra-and inter-tumoral heterogeneity in growth dynamics and vascularity influence tumor response to radiation therapy. Quantitative imaging techniques capture these dynamics non-invasively, and these data can...

    Authors: David A. Hormuth II, Angela M. Jarrett and Thomas E. Yankeelov

    Citation: Radiation Oncology 2020 15:4

    Content type: Research

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  7. The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose o...

    Authors: Lihao Zhao, Xiaona Cai, Didi Chen, Xuxue Ye, Mengdan Gao, Lihuai Lu, Huafang Su, Meng Su, Meng Hou and Congying Xie

    Citation: Radiation Oncology 2019 15:3

    Content type: Research

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  8. Individual radiosensitivity is influencing the outcome of radiation therapy. A general ex vivo testing is very work-intensive. It is of interest to see if a significant prediction concerning the sensitivity ca...

    Authors: Theresa Mayo, Marlen Haderlein, Barbara Schuster, Anna Wiesmüller, Christian Hummel, Maximilian Bachl, Manfred Schmidt, Rainer Fietkau and Luitpold Distel

    Citation: Radiation Oncology 2019 15:2

    Content type: Research

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  9. Iodine seed implant brachytherapy is indicated for low risk and selected favorable intermediate risk prostate cancers. A percentage of positive biopsies > 50% is usually considered as a contra-indication, and ...

    Authors: Claire Meynard, Andres Huertas, Charles Dariane, Sandra Toublanc, Quentin Dubourg, Saik Urien, Marc-Olivier Timsit, Arnaud Méjean, Nicolas Thiounn and Philippe Giraud

    Citation: Radiation Oncology 2019 15:1

    Content type: Research

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  10. Volumetric Modulated Arc Therapy (VMAT) techniques have recently been implemented in clinical practice for total-body irradiation (TBI). To date, most techniques still use special couches, translational tables...

    Authors: Christoph Losert, Roel Shpani, Robert Kießling, Philipp Freislederer, Minglun Li, Franziska Walter, Maximilian Niyazi, Michael Reiner, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2019 14:244

    Content type: Research

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  11. Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative...

    Authors: Yolanda D. Tseng, Shadonna M. Maes, Gregory Kicska, Patricia Sponsellor, Erik Traneus, Tony Wong, Robert D. Stewart and Jatinder Saini

    Citation: Radiation Oncology 2019 14:243

    Content type: Research

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  12. Cardiac activity could impact the accuracy of dose assessment for the heart, pericardium and left ventricular myocardium (LVM). The purpose of this study was to explore whether it is possible to perform dose a...

    Authors: Ying Tong, Guanzhong Gong, Ming Su and Yong Yin

    Citation: Radiation Oncology 2019 14:242

    Content type: Research

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  13. The effectiveness of proton beam therapy (PBT) as initial treatment for patients with unresectable intrahepatic cholangiocarcinoma (ICC) is unclear, particularly as related to ICC histological subtypes. We per...

    Authors: Shosei Shimizu, Toshiyuki Okumura, Yoshiko Oshiro, Nobuyoshi Fukumitsu, Kuniaki Fukuda, Kazunori Ishige, Naoyuki Hasegawa, Haruko Numajiri, Keiko Murofushi, Kayoko Ohnishi, Masashi Mizumoto, Tetsuo Nonaka, Hitoshi Ishikawa and Hideyuki Sakurai

    Citation: Radiation Oncology 2019 14:241

    Content type: Research

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  14. As optic nerve sheath meningiomas (ONSM) are rare, there are no prospective studies. Our retrospective analysis focusses on a cohort of patients with uniform disease characteristics all treated with the same r...

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2019 14:240

    Content type: Research

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  15. conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

    Authors: Juliette Thariat, Julia Salleron, Celia Maschi, Edouard Fevrier, Sandra Lassalle, Lauris Gastaud, Stephanie Baillif, Audrey Claren, Florent Baumard, Joel Herault and Jean Pierre Caujolle

    Citation: Radiation Oncology 2019 14:239

    Content type: Research

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  16. Helical tomotherapy has been applied to total marrow irradiation (HT-TMI). Our objective was to apply failure mode and effects analysis (FMEA) two times separated by 1 year to evaluate and improve the safety o...

    Authors: Jiuling Shen, Xiaoyong Wang, Di Deng, Jian Gong, Kang Tan, Hongli Zhao, Zhirong Bao, Jinping Xiao, An Liu, Yunfeng Zhou, Hui Liu and Conghua Xie

    Citation: Radiation Oncology 2019 14:238

    Content type: Research

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  17. In this study, a novel pelvic phantom was developed and used to assess the visibility and presence of artefacts from different types of commercial fiducial markers (FMs) on multi-modality imaging relevant to p...

    Authors: Sarah O. S. Osman, Emily Russell, Raymond B. King, Karen Crowther, Suneil Jain, Cormac McGrath, Alan R. Hounsell, Kevin M. Prise and Conor K. McGarry

    Citation: Radiation Oncology 2019 14:237

    Content type: Research

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  18. Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence.

    Authors: Hikaru Kubota, Kayoko Tsujino, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Satoshi Yamaguchi and Ryohei Sasaki

    Citation: Radiation Oncology 2019 14:236

    Content type: Research

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  19. To update the clinical outcome of an elderly women cohort with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interst...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi

    Citation: Radiation Oncology 2019 14:234

    Content type: Short report

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  20. Tomotherapy-based total body irradiation (TBI) is performed using the head-first position (HFP) and feet-first position (FFP) due to treatment length exceeding the 135 cm limit. To reduce the dosimetric variat...

    Authors: Chae-Seon Hong, Min-Joo Kim, Jihun Kim, Kyung Hwan Chang, Kwangwoo Park, Dong Wook Kim, Min Cheol Han, Hong In Yoon, Jin Sung Kim and Ho Lee

    Citation: Radiation Oncology 2019 14:233

    Content type: Research

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  21. The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head m...

    Authors: Julian Mangesius, Thomas Seppi, Rocco Weigel, Christoph Reinhold Arnold, Danijela Vasiljevic, Georg Goebel, Peter Lukas, Ute Ganswindt and Meinhard Nevinny-Stickel

    Citation: Radiation Oncology 2019 14:231

    Content type: Research

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  22. How to protect the ovarian function during radiotherapy is uncertain. The purpose of this study was to explore the association between the location of the transposed ovary and the ovarian dose in patients with...

    Authors: Xiao-juan Lv, Xiao-long Cheng, Ye-qiang Tu, Ding-ding Yan and Qiu Tang

    Citation: Radiation Oncology 2019 14:230

    Content type: Research

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  23. The new staging system of cervical cancer issued in 2018 by the International Federation of Gynecology and Obstetrics (FIGO), calls for a new evaluation of the efficacy of prophylactic extended field irradiati...

    Authors: Qingyu Meng, Xiaoliang Liu, Weiping Wang, Xiaorong Hou, Xin Lian, Shuai Sun, Junfang Yan, Zhikai Liu, Zheng Miao, Ke Hu and Fuquan Zhang

    Citation: Radiation Oncology 2019 14:228

    Content type: Research

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  24. Current standard of treatment for newly diagnosed patients with glioblastoma (GBM) is surgical resection with adjuvant normofractionated radiotherapy (NFRT) combined with temozolomide (TMZ) chemotherapy. Hyper...

    Authors: Victor Lewitzki, Rainer J. Klement, Rebekka Kosmala, Dominik Lisowski, Michael Flentje and Bülent Polat

    Citation: Radiation Oncology 2019 14:227

    Content type: Research

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  25. To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-w...

    Authors: Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M. Ito, Nobuo Shinohara, Hiroki Shirato and Shinichi Shimizu

    Citation: Radiation Oncology 2019 14:226

    Content type: Research

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  26. The purpose of this study was to determine the associations between pathological complete remission (pCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) w...

    Authors: Kai Wang, Junlin Yi, Xiaodong Huang, Yuan Qu, Jingwei Luo, Jianping Xiao, Shiping Zhang, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Zhengang Xu, Shaoyan Liu and Xiaolei Wang

    Citation: Radiation Oncology 2019 14:225

    Content type: Research

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  27. To develop a novel approach to accurately verify patient set up in proton radiotherapy, especially for the verification of the nozzle – body surface air gap and source-to-skin distance (SSD), the consistency a...

    Authors: Xiao Wang, Chi Ma, Rihan Davis, Rahul R. Parikh, Salma K. Jabbour, Bruce G. Haffty, Ning J. Yue, Ke Nie and Yin Zhang

    Citation: Radiation Oncology 2019 14:224

    Content type: Research

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  28. The addition of regional nodal radiation (RNI) to whole breast irradiation for high risk breast cancer improves metastases free survival and new data suggests it contributes additional benefit to overall survi...

    Authors: Chloe Pandeli, Lloyd M. L. Smyth, Steven David and Andrew W. See

    Citation: Radiation Oncology 2019 14:223

    Content type: Research

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  29. Mast Cell Activation Syndrome (MCAS) is classified as an idiopathic mast cell disorder where inconsistent or unknown triggers release inflammatory mediators and cause a constellation of symptoms. Studies demon...

    Authors: Robin E. Landy, William C. Stross, Jackson M. May, Tasneem A. Kaleem, Timothy D. Malouff, Mark R. Waddle and Laura A. Vallow

    Citation: Radiation Oncology 2019 14:222

    Content type: Case report

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  30. The aim of this study was to explore the relationships between dosimetric parameters of organs at risk and patient-reported outcomes (PRO) after radiotherapy of patients with head and neck cancer.

    Authors: Toyokazu Hayakawa, Shogo Kawakami, Itaru Soda, Takuro Kainuma, Marika Nozawa, Akane Sekiguchi, Shunsuke Miyamoto, Taku Yamashita and Hiromichi Ishiyama

    Citation: Radiation Oncology 2019 14:221

    Content type: Research

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  31. A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translatin...

    Authors: Slavisa Tubin, Martin Ashdown and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:220

    Content type: Short report

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  32. The microscopic tumor spread (MS) beyond the macroscopic tumor borders of esophageal tumors is crucial for determining the clinical target volume (CTV) in radiotherapy. The question arises whether current volu...

    Authors: Melanie Machiels, Maurits L. van Montfoort, Nikki B. Thuijs, Mark I. van Berge Henegouwen, Tanja Alderliesten, Sybren L. Meijer, Jeanin E. van Hooft and Maarten C. C. M. Hulshof

    Citation: Radiation Oncology 2019 14:219

    Content type: Research

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  33. In order to locate an arteriovenous malformation, typically, a digital subtraction angiography (DSA) is carried out. To use the DSA for target definition an accurate image registration between CT and DSA is re...

    Authors: Daniel Schmidhalter, Dominik Henzen, Evelyn Herrmann, Werner Volken, Paul-Henry Mackeprang, Ekin Ermis, Hossein Hemmatazad, Jonas Honegger, Benjamin Haas, Michael K. Fix and Peter Manser

    Citation: Radiation Oncology 2019 14:217

    Content type: Research

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  34. PRIMO is a graphical environment based on PENELOPE Monte Carlo (MC) simulation of radiotherapy beams able to compute dose distribution in patients, from plans with different techniques. The dosimetric characte...

    Authors: Lucia Paganini, Giacomo Reggiori, Antonella Stravato, Valentina Palumbo, Pietro Mancosu, Francesca Lobefalo, Anna Gaudino, Antonella Fogliata, Marta Scorsetti and Stefano Tomatis

    Citation: Radiation Oncology 2019 14:216

    Content type: Research

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  35. This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer.

    Authors: Jingwen Wang, Yun Guan, Weilie Gu, Senxiang Yan, Juying Zhou, Dan Huang, Tong Tong, Chao Li, Sanjun Cai, Zhen Zhang and Ji Zhu

    Citation: Radiation Oncology 2019 14:215

    Content type: Research

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  36. Treatment options for recurrent head and neck tumours in the previously irradiated area are limited, including re-irradiation due to radioresistance of the recurrent tumour and previous dose received by surrou...

    Authors: Vesna Todorovic, Ajda Prevc, Martina Niksic Zakelj, Monika Savarin, Andreja Brozic, Blaz Groselj, Primoz Strojan, Maja Cemazar and Gregor Sersa

    Citation: Radiation Oncology 2019 14:214

    Content type: Research

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  37. Accurate and standardized descriptions of organs at risk (OARs) are essential in radiation therapy for treatment planning and evaluation. Traditionally, physicians have contoured patient images manually, which...

    Authors: Sang Hee Ahn, Adam Unjin Yeo, Kwang Hyeon Kim, Chankyu Kim, Youngmoon Goh, Shinhaeng Cho, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Taeyoon Kim, Tae Hyun Kim, Sang Hee Youn, Eun Sang Oh and Jong Hwi Jeong

    Citation: Radiation Oncology 2019 14:213

    Content type: Research

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  38. Radiotherapy-induced lymphopenia may be limiting the success of therapy and could also negatively affect the ability of immune system in mediating the bystander (BE) and abscopal effects (AE). A novel SBRT-bas...

    Authors: Slavisa Tubin, Mohammad K. Khan, Gerardo Salerno, Waleed F. Mourad, Weisi Yan and Branislav Jeremic

    Citation: Radiation Oncology 2019 14:212

    Content type: Methodology

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  39. To report dosimetry and early adverse effects, aesthetic, and patient-reported outcomes of a prospective study of 3-fraction pencil-beam scanning (PBS) proton accelerated partial irradiation (APBI).

    Authors: Robert W. Mutter, Krishan R. Jethwa, Karthik Gonuguntla, Nicholas B. Remmes, Thomas J. Whitaker, Tina J. Hieken, Kathryn J. Ruddy, Lisa A. McGee, Kimberly S. Corbin and Sean S. Park

    Citation: Radiation Oncology 2019 14:211

    Content type: Research

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  40. Small cell carcinoma of the esophagus (SCCE) is characterized by its progressive feature and poor prognosis. There is no consensus on a standard therapeutic modality for SCCE. In this study, we aimed to charac...

    Authors: Baoqing Chen, Han Yang, Huali Ma, Qiaoqiao Li, Bo Qiu, Yonghong Hu and Yujia Zhu

    Citation: Radiation Oncology 2019 14:210

    Content type: Research

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  41. Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also be...

    Authors: Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki and Susumu Kanazawa

    Citation: Radiation Oncology 2019 14:209

    Content type: Research

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  42. Despite increasing clinical data suggest that internal mammary node (IMN) irradiation would improve local-regional control and overall survival in breast cancer, its role remains controversial due to increased...

    Authors: Yujie Wang, Weixiang Qi, Haoping Xu, Miao Zhang, Yimin Han, Jiayi Chen and Cheng Xu

    Citation: Radiation Oncology 2019 14:208

    Content type: Research

    Published on:

  43. The purpose of this study was to compare carbon-ion (C-ion), proton and photon radiotherapy (RT) plans with regard to dose reduction of the gastrointestinal (GI) tract by using a greater omentum spacer (GO spa...

    Authors: Masayoshi Yamada, Hiraku Sato, Yoshiro Ieko, Yuya Miyasaka, Takayuki Kanai, Natsuko Yano, Takashi Ono, Hiroko Akamatsu, Mayumi Harada, Mayumi Ichikawa, Yasushi Teranishi, Yasuhiro Kikuchi and Kenji Nemoto

    Citation: Radiation Oncology 2019 14:207

    Content type: Research

    Published on:

  44. To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiat...

    Authors: Xiyin Guan, Jing Gao, Jiyi Hu, Weixu Hu, Jing Yang, Xianxin Qiu, Chaosu Hu, Lin Kong and Jiade J. Lu

    Citation: Radiation Oncology 2019 14:206

    Content type: Research

    Published on:

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