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  1. Hybrid magnetic resonance (MR)-Linac systems have recently been introduced into clinical practice. The systems allow online adaption of the treatment plan with the aim of compensating for interfractional anato...

    Authors: Lukas Nierer, Chukwuka Eze, Vanessa da Silva Mendes, Juliane Braun, Patrick Thum, Rieke von Bestenbostel, Christopher Kurz, Guillaume Landry, Michael Reiner, Maximilian Niyazi, Claus Belka and Stefanie Corradini
    Citation: Radiation Oncology 2022 17:53
  2. Upper tract urothelial carcinoma (UTUC) is rare and the treatment for recurrent or metastatic UTUC is unclear. We evaluated the outcomes of salvage and palliative radiotherapy (RT) and prognostic factors in UT...

    Authors: Mi Sun Kim, Woong Sub Koom, Jae Ho Cho, Se-Young Kim and Ik Jae Lee
    Citation: Radiation Oncology 2022 17:51
  3. Variable relative biological effectiveness (vRBE) in proton therapy might significantly modify the prediction of RBE-weighted dose delivered to a patient during proton therapy. In this study we will present a ...

    Authors: Magdalena Garbacz, Jan Gajewski, Marco Durante, Kamil Kisielewicz, Nils Krah, Renata Kopeć, Paweł Olko, Vincenzo Patera, Ilaria Rinaldi, Marzena Rydygier, Angelo Schiavi, Emanuele Scifoni, Tomasz Skóra, Agata Skrzypek, Francesco Tommasino and Antoni Rucinski
    Citation: Radiation Oncology 2022 17:50
  4. In-field dermatitis is a severe and common adverse effect of radiation therapy, that can cause significant pain and treatment interruptions in patients with squamous cell anal carcinoma (SCAC) being treated wi...

    Authors: Fabiana Hottz, Daniel Herchenhorn, Juliana Lenzi, Juliana Andrade, Vinicius Freire and Pedro Pinho
    Citation: Radiation Oncology 2022 17:49
  5. To explore clinical and dosimetric predictors of acute hematologic toxicity (HT) in cervical cancer patients treated with concurrent chemotherapy and volumetric-modulated arc therapy (VMAT).

    Authors: Xiaoyong Xiang, Zhen Ding, Qi Zeng, Lingling Feng, Chunyan Qiu, Dongjie Chen, Jiawei Lu and Ning Li
    Citation: Radiation Oncology 2022 17:48
  6. To study lymphatic recurrence distribution after radical surgery in the real world and guide clinical tumor volume delineation for regional lymph nodes during postoperative radiotherapy for lower thoracic squa...

    Authors: Rongxu Du, Songqing Fan, Xiaobin Wang, Xia Hou, Cheng Zeng, Dan Guo, Rongrong Tian, Dan Yang, Leilei Jiang, Xin Dong, Rong Yu, Huiming Yu, Dongming Li, Shuchai Zhu, Jie Li and Anhui Shi
    Citation: Radiation Oncology 2022 17:47
  7. The interplay effect of respiratory motion on the planned dose in free-breathing right-sided whole-breast irradiation (WBI) were studied by simulating hypofractionated VMAT treatment courses.

    Authors: Mikko Mankinen, Tuomas Virén, Jan Seppälä, Heikki Hakkarainen and Tuomas Koivumäki
    Citation: Radiation Oncology 2022 17:46
  8. Multimodal therapies based on surgical resection have been recommended for the treatment of adenocarcinoma of the oesophagogastric junction (AEG). We aimed to evaluate prognostic factors in AEG patients receiv...

    Authors: Rongxu Du, Jiao Ming, Jianhao Geng, Xianggao Zhu, Yangzi Zhang, Shuai Li, Zhiyan Liu, Hongzhi Wang, Zhilong Wang, Lei Tang, Xiaotian Zhang, Aiwen Wu, Zhaode Bu, Yan Yan, Zhongwu Li, Yongheng Li…
    Citation: Radiation Oncology 2022 17:45
  9. Online MR-guided radiotherapy (MRgRT) is a relatively novel advancement in the field of radiation oncology, ensuring superior soft-tissue visualisation, allowing for online plan adaptation to anatomical and fu...

    Authors: Chukwuka Eze, Elia Lombardo, Lukas Nierer, Yuqing Xiong, Maximilian Niyazi, Claus Belka, Farkhad Manapov and Stefanie Corradini
    Citation: Radiation Oncology 2022 17:43
  10. In infrared reflective (IR) marker-based hybrid real-time tumor tracking (RTTT), the internal target position is predicted with the positions of IR markers attached on the patient’s body surface using a predic...

    Authors: Dejun Zhou, Mitsuhiro Nakamura, Nobutaka Mukumoto, Hiroaki Tanabe, Yusuke Iizuka, Michio Yoshimura, Masaki Kokubo, Yukinori Matsuo and Takashi Mizowaki
    Citation: Radiation Oncology 2022 17:42
  11. The aim of this study was to clarify the association between intrafractional prostate shift and hydrogel spacer.

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Ryosuke Takenaka, Yuki Nozawa, Yuichi Watanabe, Toshikazu Imae and Osamu Abe
    Citation: Radiation Oncology 2022 17:41
  12. Some patients have noted a foul odor during radiation therapy sessions, but the cause of the odor remains unknown. Since we suspected that this phenomenon is due to ozone generated by ionizing radiation, this ...

    Authors: N. Hara, J. Oobuchi, A. Isobe, S. Sugimoto, J. Takatsu and K. Sasai
    Citation: Radiation Oncology 2022 17:39
  13. Boosting dominant intra-prostatic lesions (DILs) has the potential to increase the therapeutic ratio in prostate cancer radiotherapy. In this study, employing 5-fraction stereotactic ablative radiotherapy (SAB...

    Authors: Sarah O. S. Osman, Ciaran Fairmichael, Glenn Whitten, Gavin S. Lundy, Rachel Wesselman, Melissa LaBonte Wilson, Alan R. Hounsell, Kevin M. Prise, Denise Irvine, Conor K. McGarry and Suneil Jain
    Citation: Radiation Oncology 2022 17:38
  14. The use of stereotactic body radiation therapy (SBRT) for tumor and pain control in patients with bone metastases is increasing. We report response assessment after bone SBRT using radiological changes through...

    Authors: Dora Correia, Barbara Moullet, Jennifer Cullmann, Rafael Heiss, Ekin Ermiş, Daniel M. Aebersold and Hossein Hemmatazad
    Citation: Radiation Oncology 2022 17:37
  15. The impact of radiotherapy interruption due to the Spring Festival holidays in China on the survival of patients with nasopharyngeal carcinoma (NPC) is unclear.

    Authors: Cheng Xu, Kai-Bin Yang, Rui-Jia Feng, Lei Chen, Xiao-Jing Du, Yan-Ping Mao, Wen-Fei Li, Qing Liu, Ying Sun and Jun Ma
    Citation: Radiation Oncology 2022 17:36
  16. This study aimed to investigate preoperative spirometry and BMI as early predictors of the mean heart and lung dose (MHD, MLD) in deep inspiration breath-hold (DIBH) radiotherapy.

    Authors: Yutaro Koide, Hidetoshi Shimizu, Takahiro Aoyama, Tomoki Kitagawa, Risei Miyauchi, Yui Watanabe, Hiroyuki Tachibana and Takeshi Kodaira
    Citation: Radiation Oncology 2022 17:35
  17. Vaginal bleeding (VB) is common in women with gynecologic (GYN) malignancies. Radiation therapy (RT) is used for the definitive treatment of GYN cancers and palliation of bleeding. The historical dogma is that...

    Authors: Luke A. Moradi, Craig S. Schneider, Alok S. Deshane, Richard A. Popple, Robert Y. Kim and Samuel R. Marcrom
    Citation: Radiation Oncology 2022 17:34
  18. To date, no data on the effect of adjuvant postmastectomy radiotherapy (PMRT) on oncologic outcomes, such as all-cause death, locoregional recurrence (LRR), and distant metastasis (DM), are available in women ...

    Authors: Jiaqiang Zhang, Shao-Yin Sum, Jeng-Guan Hsu, Ming-Feng Chiang, Tian-Shyug Lee and Szu-Yuan Wu
    Citation: Radiation Oncology 2022 17:33
  19. Factors associated with long-term survival in gemcitabine-concurrent proton radiotherapy (GPT) for non-metastatic, locally advanced pancreatic cancer (LAPC) remain unclear. This study aimed to determine the fa...

    Authors: Yuta Ogura, Kazuki Terashima, Yoshihide Nanno, SungChul Park, Masaki Suga, Daiki Takahashi, Yoshiro Matsuo, Nor Shazrina Sulaiman, Sunao Tokumaru, Tomoaki Okimoto, Hirochika Toyama and Takumi Fukumoto
    Citation: Radiation Oncology 2022 17:32
  20. This paper describes the development of a predicted electronic portal imaging device (EPID) transmission image (TI) using Monte Carlo (MC) and deep learning (DL). The measured and predicted TI were compared fo...

    Authors: Jun Zhang, Zhibiao Cheng, Ziting Fan, Qilin Zhang, Xile Zhang, Ruijie Yang and Junhai Wen
    Citation: Radiation Oncology 2022 17:31
  21. Several studies have reported patient-related risk factors for late rectal bleeding following conventionally fractionated radiotherapy for prostate cancer. We investigated patient-related risk factors for late...

    Authors: Tae Gyu Kim, Byungdo Park, Yun Gyu Song, Hyoun Wook Lee, Tae Hee Oh, Dong-Soo Ryu, Seung Chan Jeong, Daehyeon Cho, Jieun Oh, Kwang Min Kim, Jung Won Lee, Hyoun Soo Lee, Sung Min Kong, Jun Young Kim and Haeyoung Kim
    Citation: Radiation Oncology 2022 17:30
  22. Stage III non-small cell lung cancer (NSCLC) represents a highly heterogeneous disease and treatment burden. Advances in imaging modality show promising results for radiotherapy planning. In this multicentric ...

    Authors: Matthias Mäurer, Lukas Käsmann, Daniel F. Fleischmann, Michael Oertel, Danny Jazmati and Daniel Medenwald
    Citation: Radiation Oncology 2022 17:29
  23. With the rapid growth of deep learning research for medical applications comes the need for clinical personnel to be comfortable and familiar with these techniques. Taking a proven approach, we developed a str...

    Authors: John C. Asbach, Anurag K. Singh, L. Shawn Matott and Anh H. Le
    Citation: Radiation Oncology 2022 17:28
  24. Current literature lacks a comparison of lymph node metastases and non-pathological lymph nodes distribution in breast cancer patients. The aim of the current retrospective study was to generate a comprehensiv...

    Authors: Kai J. Borm, Lucia Ernst, Julia Voppichler, Markus Oechsner, Mathias Düsberg, Gabriel Buschner, Wolfgang Weber, Stephanie E. Combs and Marciana N. Duma
    Citation: Radiation Oncology 2022 17:27
  25. In the modern era of magnetic resonance imaging (MRI) staging, the benefit of prophylactic cranial irradiation (PCI) in patients with small-cell lung cancer (SCLC) has been controversial. This study evaluated ...

    Authors: Yu Jin Lim, Changhoon Song and Hak Jae Kim
    Citation: Radiation Oncology 2022 17:26
  26. Artificial intelligence (AI) shows great potential to streamline the treatment planning process. However, its clinical adoption is slow due to the limited number of clinical evaluation studies and because ofte...

    Authors: Esther Kneepkens, Nienke Bakx, Maurice van der Sangen, Jacqueline Theuws, Peter-Paul van der Toorn, Dorien Rijkaart, Jorien van der Leer, Thérèse van Nunen, Els Hagelaar, Hanneke Bluemink and Coen Hurkmans
    Citation: Radiation Oncology 2022 17:25
  27. To develop an auxiliary GPU-accelerated proton therapy (PT) dose and LETd engine for the IBA Proteus®ONE PT system. A pediatric low-grade glioma case study is reported using FRoG during clinical practice, highlig...

    Authors: Stewart Mein, Benedikt Kopp, Anthony Vela, Pauline Dutheil, Paul Lesueur, Dinu Stefan, Jürgen Debus, Thomas Haberer, Amir Abdollahi, Andrea Mairani and Thomas Tessonnier
    Citation: Radiation Oncology 2022 17:23
  28. Respiratory motion may introduce errors during radiotherapy. This study aims to assess and validate internal gross tumour volume (IGTV) margins in proximal and distal borders of gastroesophageal junction (GEJ)...

    Authors: Jinming Shi, Yuan Tang, Ning Li, Yongwen Song, Shulian Wang, Yueping Liu, Hui Fang, Ningning Lu, Yu Tang, Shunan Qi, Bo Chen, Yexiong Li, Wenyang Liu and Jing Jin
    Citation: Radiation Oncology 2022 17:22
  29. The evaluation of automatic segmentation algorithms is commonly performed using geometric metrics. An analysis based on dosimetric parameters might be more relevant in clinical practice but is often lacking in...

    Authors: Maria Kawula, Dinu Purice, Minglun Li, Gerome Vivar, Seyed-Ahmad Ahmadi, Katia Parodi, Claus Belka, Guillaume Landry and Christopher Kurz
    Citation: Radiation Oncology 2022 17:21
  30. Ultrahypofractionation can shorten the irradiation period. This study is the first dosimetric investigation comparing ultrahypofractionation using volumetric arc radiation therapy (VMAT) and intensity-modulate...

    Authors: Puntiwa Oonsiri, Chonnipa Nantavithya, Chawalit Lertbutsayanukul, Thanaporn Sarsitthithum, Mananchaya Vimolnoch, Tanawat Tawonwong and Kitwadee Saksornchai
    Citation: Radiation Oncology 2022 17:20
  31. Prostate cancer is the most common cancer among men, and its diagnosis and treatment are improving. Our study evaluated how PSMA-PET/CT prior to treatment planning might improve the optimal management of prost...

    Authors: Vasileios Karagiannis, Viktor Wichmann, Juha Saarinen, Natalja Eigeliene, Heidi Andersen and Antti Jekunen
    Citation: Radiation Oncology 2022 17:19
  32. Pain symptoms in the upper abdomen and back are prevalent in 80% of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC), where the current standard treatment is a systemic therapy consisting of a...

    Authors: M. Pavic, M. Niyazi, L. Wilke, S. Corradini, M. Vornhülz, U. Mansmann, A. Al Tawil, R. Fritsch, J. Hörner-Rieber, J. Debus, M. Guckenberger, C. Belka, J. Mayerle and G. Beyer
    Citation: Radiation Oncology 2022 17:18
  33. Radiotherapy (RT) is a mainstay of treatment for patients with glioblastoma (GB). Early clinical trials show that short course hypofractionation showed no survival benefit compared to conventional regimens wit...

    Authors: Kelly J. McKelvey, Amanda L. Hudson, Heather Donaghy, Shihani P. Stoner, Helen R. Wheeler, Connie I. Diakos and Viive M. Howell
    Citation: Radiation Oncology 2022 17:17
  34. The 106-Ruthenium contact plaque applicator is utilized for the treatment of intraocular tumor within a thickness of less than 6 mm. If anything obstructs the placement of the plaque applicator, the treatment ...

    Authors: Satoshi Nakamura, Naoya Murakami, Shigenobu Suzuki, Kimiteru Ito, Mihiro Takemori, Hiroki Nakayama, Keita Kaga, Takahito Chiba, Kotaro Iijima, Kana Takahashi, Tomonori Goka, Jun Itami, Hiroyuki Okamoto and Hiroshi Igaki
    Citation: Radiation Oncology 2022 17:16
  35. Although glioblastoma (GB) is associated with a devastating prognosis, a small proportion of patients achieve long-term survival rates. We herein present a matched-pair analysis of molecular factors found in l...

    Authors: Vivien N. Sommerlath, Daniel Buergy, Nima Etminan, Stefanie Brehmer, David Reuss, Gustavo R. Sarria, Marie-Christin Guiot, Daniel Hänggi, Frederik Wenz, Kevin Petrecca and Frank A. Giordano
    Citation: Radiation Oncology 2022 17:15
  36. The addition of consolidation chemotherapy to preoperative short-course radiotherapy during the prolonged interval between the completion of radiation and surgery in locally advanced rectal cancer (LARC) could...

    Authors: Haoyan Wu, Chuanwen Fan, Chao Fang, Libin Huang, Yuan Li and Zongguang Zhou
    Citation: Radiation Oncology 2022 17:14
  37. To define the clinical characteristics of irradiation-induced nasopharyngeal necrosis (INN) after intensity-modulated radiotherapy (IMRT) and identify the influence of treatment strategies on INN in primary na...

    Authors: Yi Xu, Yang Liu, Zekun Wang, Jingbo Wang, Jianghu Zhang, Xuesong Chen, Runye Wu, Qingfeng Liu, Yuan Qu, Kai Wang, Xiaodong Huang, Jingwei Luo, Li Gao, Guozhen Xu, Ye Zhang and Junlin Yi
    Citation: Radiation Oncology 2022 17:13
  38. To evaluate acute and late genitourinary and gastrointestinal toxicities and patient reported urinary and sexual function following accelerated, hypofractionated external beam radiotherapy to the prostate, sem...

    Authors: Christina Phuong, Jason W. Chan, Lisa Ni, Phillip Wall, Osama Mohamad, Anthony C. Wong, I.-Chow Hsu and Albert J. Chang
    Citation: Radiation Oncology 2022 17:12
  39. Although chemoradiotherapy (CRT) is one of the curative treatments for thoracic esophageal squamous cell carcinoma (ESCC) with submucosal invasion, the risk of local recurrence after CRT remains a clinical pro...

    Authors: Tomohiko Miyazaki, Miyako Myojin, Masao Hosokawa, Hidefumi Aoyama, Satoshi Okahara and Hiroaki Takahashi
    Citation: Radiation Oncology 2022 17:11
  40. Low dose radiotherapy (LDRT) of whole lungs with photon beams is a novel method for treating COVID-19 pneumonia. This study aimed to estimate cancer risks induced by lung LDRT for different radiotherapy delive...

    Authors: Amin Banaei, Bijan Hashemi and Mohsen Bakhshandeh
    Citation: Radiation Oncology 2022 17:10
  41. Chemoradiotherapy (CRT) followed by a brachytherapy (BT) boost is the standard of care for patients with locally advanced or recurrent gynecological cancer (LARGC). However, not every patient is suitable for B...

    Authors: Indrawati Hadi, Chukwuka Eze, Stephan Schönecker, Rieke von Bestenbostel, Paul Rogowski, Lukas Nierer, Raphael Bodensohn, Michael Reiner, Guillaume Landry, Claus Belka, Maximilian Niyazi and Stefanie Corradini
    Citation: Radiation Oncology 2022 17:8
  42. Concurrent chemoradiotherapy (CCRT) followed by durvalumab is the standard of care for unresectable locally-advanced non-small cell carcinoma (LA-NSCLC). However, a major concern about administration of durval...

    Authors: Hiroshi Mayahara, Kazuyuki Uehara, Aya Harada, Keiji Kitatani, Tomonori Yabuuchi, Shuichirou Miyazaki, Takeaki Ishihara, Hiroki Kawaguchi, Hikaru Kubota, Hideaki Okada, Taira Ninomaru, Chihiro Shindo and Akito Hata
    Citation: Radiation Oncology 2022 17:7
  43. To investigate the prognostic relevance of specific measurement parameters such as tumor diameter, tumor volume, tumor volume reduction rate (TVRR), and changes in the squamous cell carcinoma antigen (SCC-Ag) ...

    Authors: Wenjuan Chen, Siyi Xiu, Xingyun Xie, Huiming Guo, Yuanji Xu, Penggang Bai and Xiaoyi Xia
    Citation: Radiation Oncology 2022 17:6
  44. To characterise the motion of pulmonary tumours during stereotactic body radiation therapy (SBRT) and to evaluate different margins when creating the planning target volume (PTV) on a single 4D CT scan (4DCT).

    Authors: Pierre Trémolières, Ana Gonzalez-Moya, Amaury Paumier, Martine Mege, Julien Blanchecotte, Christelle Theotime, Damien Autret and Stéphane Dufreneix
    Citation: Radiation Oncology 2022 17:5
  45. Re-irradiation (re-RT) is a technically challenging task for which few standardized approaches exist. This is in part due to the lack of a common platform to assess dose tolerance in relation to toxicity in th...

    Authors: Eric D. Brooks, Xiaochun Wang, Brian De, Vivek Verma, Tyler D. Williamson, Rachel Hunter, Abdallah S. R. Mohamed, Matthew S. Ning, Xiaodong Zhang and Joe Y. Chang
    Citation: Radiation Oncology 2022 17:4
  46. High-quality radiotherapy (RT) planning for children and young adults with primary brain tumours is essential to minimize the risk of late treatment effects. The feasibility of using automated machine-learning...

    Authors: Derek S. Tsang, Grace Tsui, Chris McIntosh, Thomas Purdie, Glenn Bauman, Hitesh Dama, Normand Laperriere, Barbara-Ann Millar, David B. Shultz, Sameera Ahmed, Mohammad Khandwala and David C. Hodgson
    Citation: Radiation Oncology 2022 17:3

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