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  1. Content type: Research

    The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).

    Authors: Mingqiu Chen, Minmin Shen, Yu Lin, Pingping Liu, Xiaohong Liu, Xiqing Li, Anchuan Li, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Benhua Xu, Jianhua Lin, Junqiang Chen and Ye Tian

    Citation: Radiation Oncology 2018 13:150

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  2. Content type: Commentary

    For 2018, the American Cancer Society estimated that there would be approximately 1.7 million new diagnoses of cancer and about 609,640 cancer-related deaths in the United States. By 2030 these numbers are ant...

    Authors: Paul Russell Roberts, Ashesh B. Jani, Satyaseelan Packianathan, Ashley Albert, Rahul Bhandari and Srinivasan Vijayakumar

    Citation: Radiation Oncology 2018 13:146

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  3. Content type: Research

    In the era of intensity-modulated radiotherapy (IMRT), the role of additional concurrent chemotherapy (CC) to radiotherapy (RT) after induction chemotherapy (IC) compared to IC followed by RT alone remains unc...

    Authors: Linger Liu, Zhenghua Fei, Mengfeng Chen, Lihao Zhao, Huafang Su, Dianna Gu, Baochai Lin, Xiaona Cai, Lihuai Lu, Mengdan Gao, Xuxue Ye, Xiance Jin and Congying Xie

    Citation: Radiation Oncology 2018 13:148

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  4. Content type: Research

    We aimed to evaluate the toxicity, loco-regional control (LRC) and overall survival (OS) associated with accelerated intensity-modulated radiotherapy (IMRT) for locally advanced lung cancer.

    Authors: Nicolas Jaksic, Enrique Chajon, Julien Bellec, Romain Corre, Charles Ricordel, Bertrand de Latour, Hervé Lena, Ulrike Schick, Renaud de Crevoisier and Joël Castelli

    Citation: Radiation Oncology 2018 13:147

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  5. Content type: Research

    The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the he...

    Authors: Ying Tong, Yong Yin, Pinjing Cheng and Guanzhong Gong

    Citation: Radiation Oncology 2018 13:145

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  6. Content type: Research

    The software PRIMO for the Monte Carlo simulation of radiotherapy linacs could potentially act as a independent calculation system to verify the calculations of treatment planning systems. We investigated the ...

    Authors: Marcelino Hermida–López, David Sánchez–Artuñedo and Juan Francisco Calvo–Ortega

    Citation: Radiation Oncology 2018 13:144

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  7. Content type: Research

    We sought to determine the role of abdominal reirradiation for patients presenting with recurrent or new primary gastrointestinal (GI) malignancies. At our institution, we have established a hyperfractionated,...

    Authors: Andrew Hunt, Prajnan Das, Bruce D. Minsky, Eugene J. Koay, Sunil Krishnan, Joseph M. Herman, Cullen Taniguchi, Albert Koong, Grace L. Smith and Emma B. Holliday

    Citation: Radiation Oncology 2018 13:143

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  8. Content type: Case report

    Development of primary lung cancer in donor lung post-lung transplantation is very rare, with few described cases. The safety of stereotactic ablative radiotherapy (SABR) for early-stage lung cancer arising fr...

    Authors: Hanbo Chen, Jussi Tikkanen, R. Gabriel Boldt and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:142

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  9. Content type: Research

    To compare the efficacy of ipsilateral lower neck sparing irradiation (ILNSI) versus ipsilateral lower neck prophylactic irradiation (ILNPI) for unilateral or bilateral neck node-negative nasopharyngeal cancer...

    Authors: Cheng-Long Huang, Cheng Xu, Yuan Zhang, Guan-Qun Zhou, Yan-Ping Mao, Qing Liu, Ying Sun, Jun Ma and Ling-Long Tang

    Citation: Radiation Oncology 2018 13:141

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  10. Content type: Research

    While neoadjuvant chemoradiation therapy (nCRT) with subsequent surgery is the treatment of choice for patients with locally advanced or node-positive squamous cell carcinoma of the esophagus (SCC) suitable fo...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Wilko Weichert, Helmut Friess, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:139

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  11. Content type: Research

    The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal mel...

    Authors: Sati Akbaba, Robert Foerster, Nils Henrik Nicolay, Nathalie Arians, Tilman Bostel, Juergen Debus and Henrik Hauswald

    Citation: Radiation Oncology 2018 13:140

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  12. Content type: Research

    Until 50% of patients with renal cancer or melanoma, develop brain metastases during the course of their disease. Stereotactic radiotherapy has become a standard of care for patients with a limited number of b...

    Authors: Paul Lesueur, Justine Lequesne, Victor Barraux, William Kao, Julien Geffrelot, Jean-Michel Grellard, Jean-Louis Habrand, Evelyne Emery, Brigitte Marie, Juliette Thariat and Dinu Stefan

    Citation: Radiation Oncology 2018 13:138

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  13. Content type: Research

    To evaluate the difference of absorbed doses calculated to medium and to water by a Monte Carlo (MC) algorithm based treatment planning system (TPS), and to assess the potential clinical impact to dose prescri...

    Authors: Li Chen, Botian Huang, Xiaoyan Huang, Wufei Cao, Wenzhao Sun and Xiaowu Deng

    Citation: Radiation Oncology 2018 13:137

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  14. Content type: Research

    This study evaluated the safety and efficacy of repeat SBRT for local recurrence of stage I non-small-cell lung cancer (NSCLC) and solitary lung metastasis.

    Authors: Yasutaka Ogawa, Yuta Shibamoto, Chisa Hashizume, Takuhito Kondo, Hiromitsu Iwata, Natsuo Tomita and Hiroyuki Ogino

    Citation: Radiation Oncology 2018 13:136

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  15. Content type: Research

    To evaluate the clinical outcomes of patients treated with 3D conformal Hypo-fractionated, deep Inspiratory breath-hold (DIBH), Partial breast radiotherapy, termed “HIP.” HIP was implemented to merge the schedule...

    Authors: Roman O. Kowalchuk, Kara D. Romano, Daniel M. Trifiletti, Sunil W. Dutta, Timothy N. Showalter and Monica M. Morris

    Citation: Radiation Oncology 2018 13:135

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  16. Content type: Research

    The effect of radiotherapy, in particular the application of different multi-fraction schedules in the management of unstable spinal bone metastases (SBM), is incompletely understood. This study aims to compar...

    Authors: Tanja Sprave, Katharina Hees, Thomas Bruckner, Robert Foerster, Tilman Bostel, Ingmar Schlampp, Rami El Shafie, Nils Henrik Nicolay, Juergen Debus and Harald Rief

    Citation: Radiation Oncology 2018 13:134

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  17. Content type: Research

    Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways.

    Authors: Dasantha Jayamanne, Helen Wheeler, David Brazier, Allison Newey, Marina Kastelan, Linxin Guo and Michael Back

    Citation: Radiation Oncology 2018 13:133

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  18. Content type: Research

    Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 – WBRT-Mel) evaluates the role of adjuvant whole brain rad...

    Authors: Geoffrey Martinage, Angela M. Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo and Gerald Fogarty

    Citation: Radiation Oncology 2018 13:132

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  19. Content type: Research

    Gene expression of specific therapeutic targets in non-malignant lung tissue might play an important role in optimizing targeted therapies. This study aims to identify different expression patterns of fifteen ...

    Authors: Kobe Reynders, Els Wauters, Matthieu Moisse, Herbert Decaluwé, Paul De Leyn, Stéphanie Peeters, Maarten Lambrecht, Kristiaan Nackaerts, Christophe Dooms, Wim Janssens, Johan Vansteenkiste, Diether Lambrechts and Dirk De Ruysscher

    Citation: Radiation Oncology 2018 13:131

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  20. Content type: Research

    To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated ...

    Authors: Li Ma, Bo Qiu, QiWen Li, Li Chen, Bin Wang, YongHong Hu, MengZhong Liu, Li Zhang, Yan Huang, XiaoWu Deng, YunFei Xia, MaoSheng Lin and Hui Liu

    Citation: Radiation Oncology 2018 13:130

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  21. Content type: Research

    Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended d...

    Authors: Kara D. Romano, Colin Hill, Daniel M. Trifiletti, M. Sean Peach, Bethany J. Horton, Neil Shah, Dylan Campbell, Bruce Libby and Timothy N. Showalter

    Citation: Radiation Oncology 2018 13:129

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  22. Content type: Research

    Intra-fraction motion represents a crucial issue in the era of precise radiotherapy in several settings, including breast irradiation. To date, only few data exist on real-time measured intra-fraction motion i...

    Authors: D. Reitz, G. Carl, S. Schönecker, M. Pazos, P. Freislederer, M. Niyazi, U. Ganswindt, F. Alongi, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2018 13:128

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  23. Content type: Research

    Linac output as a function of field sizes has a phantom and a head scatter component. This last term can be measured in-air with appropriate build-up ensuring a complete electron equilibrium and the absence of...

    Authors: A. Fogliata, A. Stravato, G. Reggiori, S. Tomatis, J. Würfel, M. Scorsetti and L. Cozzi

    Citation: Radiation Oncology 2018 13:126

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  24. Content type: Research

    Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer.

    Authors: Yeon Joo Kim, Su Ssan Kim, Si Yeol Song and Eun Kyung Choi

    Citation: Radiation Oncology 2018 13:127

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  25. Content type: Research

    Better knowledge of the dose-toxicity relationship is essential for safe dose escalation to improve local control in cervical cancer radiotherapy. The conventional dose-toxicity model is based on the dose volu...

    Authors: Jiawei Chen, Haibin Chen, Zichun Zhong, Zhuoyu Wang, Brian Hrycushko, Linghong Zhou, Steve Jiang, Kevin Albuquerque, Xuejun Gu and Xin Zhen

    Citation: Radiation Oncology 2018 13:125

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  26. Content type: Research

    Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the nee...

    Authors: Lucas C. Mendez, Alexander V. Louie, Carolina Moreno, Matt Wronski, Andrew Warner, Eric Leung, Roberto Sakuraba, Juliana K. Helito, Ana Rezende, Icaro T. Carvalho and Eduardo Weltman

    Citation: Radiation Oncology 2018 13:124

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  27. Content type: Research

    Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group “Personali...

    Authors: Cornelius Maihoefer, Lars Schüttrumpf, Corinna Macht, Ulrike Pflugradt, Julia Hess, Ludmila Schneider, Christine Woischke, Axel Walch, Philipp Baumeister, Thomas Kirchner, Horst Zitzelsberger, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2018 13:123

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  28. Content type: Research

    The benefits of proton therapy in the treatment of patients with Hodgkin lymphoma (HL) are controversially discussed. Therefore we compared intensitiy modulated proton therapy (IMPT) with intensity modulated r...

    Authors: Christian Baues, Simone Marnitz, Andreas Engert, Wolfgang Baus, Karolina Jablonska, Antonella Fogliata, Andrés Vásquez-Torres, Marta Scorsetti and Luca Cozzi

    Citation: Radiation Oncology 2018 13:122

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  29. Content type: Research

    A new implementation has been made on CloudMC, a cloud-based platform presented in a previous work, in order to provide services for radiotherapy treatment verification by means of Monte Carlo in a fast, easy ...

    Authors: Hector Miras, Rubén Jiménez, Álvaro Perales, José Antonio Terrón, Alejandro Bertolet, Antonio Ortiz and José Macías

    Citation: Radiation Oncology 2018 13:99

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  30. Content type: Review

    The use of the Monte Carlo (MC) method in radiotherapy dosimetry has increased almost exponentially in the last decades. Its widespread use in the field has converted this computer simulation technique in a co...

    Authors: Pedro Andreo

    Citation: Radiation Oncology 2018 13:121

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  31. Content type: Research

    Carbon-ion radiotherapy (C-ion RT) provides better dose distribution in cancer treatment compared to photons. Additionally, carbon-ion beams provide a higher biological effectiveness, and thus a higher tumor c...

    Authors: Noriyuki Okonogi, Mai Fukahori, Masaru Wakatsuki, Yu Ohkubo, Shingo Kato, Yuhei Miyasaka, Hiroshi Tsuji, Takashi Nakano and Tadashi Kamada

    Citation: Radiation Oncology 2018 13:119

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  32. Content type: Research

    Uncertainties associated with the delivery of treatment to moving organs might compromise the accuracy of treatment. This study explores the impact of intra-fractional anatomical changes in pancreatic patients...

    Authors: Vania Batista, Daniel Richter, Naved Chaudhri, Patrick Naumann, Klaus Herfarth and Oliver Jäkel

    Citation: Radiation Oncology 2018 13:120

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  33. Content type: Correction

    The original version of this article [1] unfortunately contained a mistake.

    Authors: Wen-zhao Sun, Dan-dan Zhang, Ying-lin Peng, Li Chen, De-hua Kang, Bin Wang and Xiao-wu Deng

    Citation: Radiation Oncology 2018 13:117

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    The original article was published in Radiation Oncology 2018 13:42

  34. Content type: Research

    The purpose was to retrospectively evaluate the effect of intensity-modulated radiotherapy (IMRT) on gastrointestinal (GI) toxicities and outcomes compared to three-dimensional conformal radiotherapy (3DCRT) f...

    Authors: Yoko Goto, Akira Nakamura, Ryo Ashida, Katsuyuki Sakanaka, Satoshi Itasaka, Keiko Shibuya, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Toshihiko Masui, Yuzo Kodama, Kyoichi Takaori, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2018 13:118

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  35. Content type: Research

    Deep inspiration breath hold (DIBH) can be performed using different breathing maneuvers, such as DIBH with a thoracic breathing maneuver (T-DIBH) and DIBH with an abdominal breathing maneuver (A-DIBH). Dosime...

    Authors: Feng Zhao, Jiayan Shen, Zhongjie Lu, Yongbiao Luo, Guorong Yao, Luyi Bu, Jia Ge, Xin Yang, Lihua Ning and Senxiang Yan

    Citation: Radiation Oncology 2018 13:116

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  36. Content type: Case report

    Granular cell or Abrikossoff’s tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional.

    Authors: C. Marchand Crety, C. Garbar, G. Madelis, F. Guillemin, P. Soibinet Oudot, J. C. Eymard and S. Servagi Vernat

    Citation: Radiation Oncology 2018 13:115

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  37. Content type: Research

    This is a dosimetric comparative study intended to establish appropriate low-to-intermediate dose-constraints for the rectal wall (Rwall) in the context of a randomized phase-II trial on urethra-sparing stereotac...

    Authors: Angèle Dubouloz, Michel Rouzaud, Lev Tsvang, Wilko Verbakel, Mikko Björkqvist, Nadine Linthout, Joana Lencart, Juan María Pérez-Moreno, Zeynep Ozen, Lluís Escude, Thomas Zilli and Raymond Miralbell

    Citation: Radiation Oncology 2018 13:114

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  38. Content type: Research

    The goal of this study is to evaluate the status and future perspectives of clinical trials on positron emission tomography in prostate cancer for diagnostic or therapeutic as well as for surveillance purposes.

    Authors: Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis, Vikas Prasad, Stephanie Kroeze, Ivan Igrutinovic, Branislav Jeremic, Marcus Beck, Sebastian Zschaeck, Peter Wust and Pirus Ghadjar

    Citation: Radiation Oncology 2018 13:113

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  39. Content type: Research

    In intensity modulated radiation therapy (IMRT) quality assurance (QA), evaluation of QA result using a pass/non-pass strategy under an acceptance criterion often suffers from lack of information on how good t...

    Authors: Dong-Su Kim, Siyong Kim, Seong-Hee Kang, Tae-Ho Kim, So-Hyun Park, Kyeong-Hyeon Kim, Min-Seok Cho, Dong-Seok Shin, Yu-Yun Noh, Jin-Beom Chung and Tae Suk Suh

    Citation: Radiation Oncology 2018 13:112

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  40. Content type: Research

    We investigated the effectiveness of one education course to lower the severity of anxiety and depression symptoms among breast cancer (BC) patients during radiotherapy (RT).

    Authors: Zhensheng Li, Wenhui Geng, Junpu Yin and Jun Zhang

    Citation: Radiation Oncology 2018 13:111

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  41. Content type: Research

    The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrenc...

    Authors: Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2018 13:110

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  42. Content type: Research

    Ion beam radiotherapy provides potential for increased dose conformation to the target volume. To translate it into a clinical advantage, it is necessary to guarantee a precise alignment of the actual internal...

    Authors: M. Martišíková, T. Gehrke, S. Berke, G. Aricò and O. Jäkel

    Citation: Radiation Oncology 2018 13:109

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  43. Content type: Research

    The purpose of this study was to evaluate the impact of markerless on-board kilovoltage (kV) cone-beam computed tomography (CBCT)-based positioning uncertainty on determination of the planning target volume (P...

    Authors: Katsumi Hirose, Mariko Sato, Yoshiomi Hatayama, Hideo Kawaguchi, Fumio Komai, Makoto Sohma, Hideki Obara, Masashi Suzuki, Mitsuki Tanaka, Ichitaro Fujioka, Koji Ichise, Yoshihiro Takai and Masahiko Aoki

    Citation: Radiation Oncology 2018 13:106

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  44. Content type: Research

    The use of intraprostatic gold fiducial markers (FMs) ensures highly accurate and precise image-guided radiation therapy for patients diagnosed with prostate cancer thanks to the ease of localising FMs on phot...

    Authors: Matteo Maspero, Peter R. Seevinck, Nicole J. W. Willems, Gonda G. Sikkes, Geja J. de Kogel, Hans C. J. de Boer, Jochem R. N. van der Voort van Zyp and Cornelis A. T. van den Berg

    Citation: Radiation Oncology 2018 13:105

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  45. Content type: Research

    Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain ...

    Authors: Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster and Eugene Wong

    Citation: Radiation Oncology 2018 13:104

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  46. Content type: Research

    While breast radiotherapy typically includes regional nodal basins, the treatment of the internal mammary nodes (IMN) has been controversial due to concern for long-term cardiac toxicity. For high risk patient...

    Authors: Macklin H. Nguyen, Myra Lavilla, Janice N. Kim and L. Christine Fang

    Citation: Radiation Oncology 2018 13:103

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  47. Content type: Case report

    The existence of abscopal effects has been suggested already a long time ago, but only recently with the advent of immune checkpoint inhibition in clinical oncology and modern imaging techniques has it become ...

    Authors: Christian Britschgi, Oliver Riesterer, Irene A. Burger, Matthias Guckenberger and Alessandra Curioni-Fontecedro

    Citation: Radiation Oncology 2018 13:102

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