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  1. Esophagitis influences quality of life and might cause treatment interruption and hospitalization. Previous studies of risk factors focused on curative treatment for non-small cell lung cancer (NSCLC), which o...

    Authors: Carsten Nieder, Kristian S. Imingen, Bård Mannsåker, Rosalba Yobuta and Ellinor Haukland

    Citation: Radiation Oncology 2020 15:91

    Content type: Research

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  2. Prognostication tools for early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) are currently lacking. The purpose of this study was to develop and external...

    Authors: Sarah Baker, Katerina Bakunina, Marloes Duijm, Mischa S. Hoogeman, Robin Cornelissen, Imogeen Antonisse, John Praag, Wilma D. Heemsbergen and Joost Jan Nuyttens

    Citation: Radiation Oncology 2020 15:89

    Content type: Research

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  3. Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are wi...

    Authors: M. Unterrainer, C. Eze, H. Ilhan, S. Marschner, O. Roengvoraphoj, N. S. Schmidt-Hegemann, F. Walter, W. G. Kunz, P. Munck af Rosenschöld, R. Jeraj, N. L. Albert, A. L. Grosu, M. Niyazi, P. Bartenstein and C. Belka

    Citation: Radiation Oncology 2020 15:88

    Content type: Review

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  4. Deep learning-based algorithms have demonstrated enormous performance in segmentation of medical images. We collected a dataset of multiparametric MRI and contour data acquired for use in radiosurgery, to eval...

    Authors: Khaled Bousabarah, Maximilian Ruge, Julia-Sarita Brand, Mauritius Hoevels, Daniel Rueß, Jan Borggrefe, Nils Große Hokamp, Veerle Visser-Vandewalle, David Maintz, Harald Treuer and Martin Kocher

    Citation: Radiation Oncology 2020 15:87

    Content type: Research

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  5. Current chemoradiation regimens for locally advanced cervical cancer are fairly uniform despite a profound diversity of treatment response and recurrence patterns. The wide range of treatment responses and pro...

    Authors: Shin-Hyung Park, Myong Hun Hahm, Bong Kyung Bae, Gun Oh Chong, Shin Young Jeong, Sungdae Na, Sungmoon Jeong and Jae-Chul Kim

    Citation: Radiation Oncology 2020 15:86

    Content type: Research

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  6. In most clinical trials, gold fiducial markers are implanted in the prostate to tune the table position before each radiation beam. Yet, it is unclear if a cone-beam computed tomography (CBCT) should be perfor...

    Authors: Omar Jmour, Marouan Benna, Pierre Champagnol, Majed Ben Mrad, Anis Hamrouni, Layal Obeid, Chaimaa Lahmamssi, Amal Bousarsar, Nicolas Vial, Amel Rehailia-Blanchard, Sandrine Sotton, Meiling Lan, Julien Langrand-Escure, Alexis Vallard and Nicolas Magné

    Citation: Radiation Oncology 2020 15:85

    Content type: Short report

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  7. To evaluate the longitudinal changes of quality of life (QoL) and survival in patients with nasopharyngeal carcinoma (NPC) treated by volumetric-modulated arc therapy (VMAT) versus intensity-modulated radiothe...

    Authors: Tai-Lin Huang, Ming-Hsien Tsai, Hui-Ching Chuang, Chih-Yen Chien, Yu-Tsai Lin, Wen-Ling Tsai and Fu-Min Fang

    Citation: Radiation Oncology 2020 15:84

    Content type: Research

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  8. Glioblastoma is a rapidly proliferating tumor. Patients bear an inferior prognosis with a median survival time of 14-16 months. Proliferation and repopulation are a major resistance promoting factor for conven...

    Authors: N. Guberina, C. Pöttgen, S. Kebir, L. Lazaridis, C. Scharmberg, W. Lübcke, M. Niessen, M. Guberina, B. Scheffler, V. Jendrossek, R. Jabbarli, D. Pierscianek, U. Sure, T. Schmidt, C. Oster, P. Hau…

    Citation: Radiation Oncology 2020 15:83

    Content type: Research

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  9. Hypofractionated stereotactic radiotherapy (HFSRT) is indicated for large brain metastases (BM) or proximity to critical organs (brainstem, chiasm, optic nerves, hippocampus). The primary aim of this study was...

    Authors: Laurence Mengue, Aurélie Bertaut, Louise Ngo Mbus, Mélanie Doré, Myriam Ayadi, Karen Clément-Colmou, Line Claude, Christian Carrie, Cécile Laude, Ronan Tanguy, Julie Blanc and Marie-Pierre Sunyach

    Citation: Radiation Oncology 2020 15:82

    Content type: Research

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  10. Treatment for local and locoregional recurrence or second head-and-neck (H&N) cancers after previous radiotherapy is challenging, and re-irradiation carries a significantly increased risk for radiotherapy-rela...

    Authors: Alexander Rühle, Tanja Sprave, Tobias Kalckreuth, Raluca Stoian, Erik Haehl, Constantinos Zamboglou, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:81

    Content type: Research

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  11. To analyze management and outcomes following (chemo)radiation therapy in patients with cervical lymph node metastases from an unknown primary site (CCUP) in a large single-center cohort.

    Authors: Tanja Sprave, Alexander Rühle, Katharina Hees, Tobias Kalckreuth, Vivek Verma, Raluca Stoian, Constantinos Zamboglou, Jens Pfeiffer, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:80

    Content type: Research

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  12. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide biomarkers of the outcome of locally-advanced cervical carcinoma (LACC). There is, however, no agreement on how DCE-MR recordings shou...

    Authors: Kjersti V. Lund, Trude G. Simonsen, Gunnar B. Kristensen and Einar K. Rofstad

    Citation: Radiation Oncology 2020 15:79

    Content type: Research

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  13. The aim of this study was to characterize changes in hippocampal inflammasomes, pyroptosis and apoptosis in juvenile rats after brain irradiation and to assess whether manganese-enhanced magnetic resonance ima...

    Authors: Jun Yang, Jingyan Gao, Dan Han, Qinqing Li, Chengde Liao, Jindan Li, Rui Wang and Yueyuan Luo

    Citation: Radiation Oncology 2020 15:78

    Content type: Research

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  14. Retrospective studies on MRI-only radiotherapy have been presented. Widespread clinical implementations of MRI-only workflows are however limited by the absence of guidelines. The MR-PROTECT trial presents an ...

    Authors: Emilia Persson, Christian Jamtheim Gustafsson, Petra Ambolt, Silke Engelholm, Sofie Ceberg, Sven Bäck, Lars E. Olsson and Adalsteinn Gunnlaugsson

    Citation: Radiation Oncology 2020 15:77

    Content type: Research

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  15. Several studies investigating the role of intraoperative radiotherapy (IORT) in the treatment of resectable pancreatic cancer (PC) have been published; however, their results remain inconsistent. By conducting...

    Authors: Liang Jin, Ning Shi, Shiye Ruan, Baohua Hou, Yiping Zou, Xiongfeng Zou, Haosheng Jin and Zhixiang Jian

    Citation: Radiation Oncology 2020 15:76

    Content type: Review

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  16. The improvement of survival outcomes and the reduction of toxicities for esophageal squamous cell carcinoma (SCC) are still needed. We conducted a pilot study of concurrent chemoradiotherapy with weekly doceta...

    Authors: Qi Liu, Yi Xia, Yun Chen, Junhua Zhang, Jiaying Deng and Kuaile Zhao

    Citation: Radiation Oncology 2020 15:75

    Content type: Research

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  17. The COVID-19 pandemic is challenging modern radiation oncology. At University Hospitals, we have a mandate to offer high-end treatments to all cancer patients. However, in times of crisis we must learn to prio...

    Authors: Stephanie E. Combs, Claus Belka, Maximilian Niyazi, Stefanie Corradini, Steffi Pigorsch, Jan Wilkens, Anca L. Grosu, Matthias Guckenberger, Ute Ganswindt and Denise Bernhardt

    Citation: Radiation Oncology 2020 15:74

    Content type: Review

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  18. To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients.

    Authors: Lucas C. Mendez, Ananth Ravi, Kevin Martell, Hamid Raziee, Yasir Alayed, Matt Wronski, Moti Paudel, Elizabeth Barnes, Amandeep Taggar, C. S. Wong and Eric Leung

    Citation: Radiation Oncology 2020 15:73

    Content type: Research

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  19. The optimal adjuvant treatment for stage III endometrial cancer in the era of modern radiotherapy remains undefined. We investigated the benefit of adjuvant radiotherapy for women who underwent optimal resecti...

    Authors: Jenny Ling-Yu Chen, Yu-Sen Huang, Chao-Yuan Huang, Che-Yu Hsu, Keng-Hsueh Lan, Wen-Fang Cheng and Sung-Hsin Kuo

    Citation: Radiation Oncology 2020 15:72

    Content type: Research

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  20. Radiation therapy is an integral part of the multidisciplinary management of breast cancer. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in...

    Authors: Jan Haussmann, Stefanie Corradini, Carolin Nestle-Kraemling, Edwin Bölke, Freddy Joel Djiepmo Njanang, Bálint Tamaskovics, Klaus Orth, Eugen Ruckhaeberle, Tanja Fehm, Svjetlana Mohrmann, Ioannis Simiantonakis, Wilfried Budach and Christiane Matuschek

    Citation: Radiation Oncology 2020 15:71

    Content type: Review

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  21. The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.

    Authors: Meng Ni, Aijun Jiang, Wenju Liu, Yanxing Sheng, Haiyan Zeng, Ning Liu, Qingxiao Gao, Yong Wang, Jinming Yu and Shuanghu Yuan

    Citation: Radiation Oncology 2020 15:70

    Content type: Research

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  22. Unity Elekta is a unique magnetic resonance (MR)-linac that conjugates a 1.5 Tesla MR unit with a 7 MV flattening filter free accelerator.A prospective observational study for the clinical use of Elekta Unity ...

    Authors: Filippo Alongi, Michele Rigo, Vanessa Figlia, Francesco Cuccia, Niccolò Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Rosario Mazzola

    Citation: Radiation Oncology 2020 15:69

    Content type: Research

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  23. We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and ...

    Authors: Ling Zhou, Jia Chen, Wei Shen, Zheng-Lu Chen, Shuang Huang, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu and Yuan-Yuan Chen

    Citation: Radiation Oncology 2020 15:68

    Content type: Research

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  24. Hypofractionated whole-breast irradiation is a standard adjuvant therapy for early-stage breast cancer. This study evaluates the plan quality and efficacy of an in-house-developed automated radiotherapy treatm...

    Authors: Ting-Chun Lin, Chih-Yuan Lin, Kai-Chiun Li, Jin-Huei Ji, Ji-An Liang, An-Cheng Shiau, Liang-Chih Liu and Ti-Hao Wang

    Citation: Radiation Oncology 2020 15:67

    Content type: Research

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  25. This study directs to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone versus IMRT plus chemotherapy in intermediate-risk NPC (stage II and T3N0M0).

    Authors: Omer Aftab, Shufang Liao, Rongjun Zhang, Nan Tang, Meiqing Luo, Bin Zhang, Sanjeev Shahi, Raju Rai, Jazib Ali and Wei Jiang

    Citation: Radiation Oncology 2020 15:66

    Content type: Research

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  26. We evaluated the relationship between patient-, tumor-, and treatment-related features and radiation-induced lymphopenia (RIL) and evaluated the correlation between RIL and survival outcome in NPC patients to ...

    Authors: Xiaoxue Xie, Shenglan Gong, Hekun Jin, Pei Yang, Ting Xu, Yilong Cai, Chengxian Guo, Rong Zhang, Fan Lou, Wenjuan Yang and Hui Wang

    Citation: Radiation Oncology 2020 15:65

    Content type: Research

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  27. This work aims at clinically validating a graphical tool developed for treatment plan assessment, named SPIDERplan, by comparing the plan choices based on its scoring with the radiation oncologists (RO) clinic...

    Authors: Tiago Ventura, Joana Dias, Leila Khouri, Eduardo Netto, André Soares, Brigida da Costa Ferreira, Humberto Rocha and Maria do Carmo Lopes

    Citation: Radiation Oncology 2020 15:64

    Content type: Research

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  28. To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs).

    Authors: Jianmin Liu, Rafael Rojas, Fred C. Lam, Farhan A. Mirza, Anand Mahadevan and Ekkehard M. Kasper

    Citation: Radiation Oncology 2020 15:63

    Content type: Research

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  29. Advances in therapy have resulted in improved cure rates and an increasing number of long-term Hodgkin's lymphoma (HL) survivors. However, radiotherapy (RT)-related late effects are still a significant issue, ...

    Authors: Andrea Riccardo Filippi, Sofia Meregalli, Anna DI Russo, Mario Levis, Patrizia Ciammella, Michela Buglione, Andrea Emanuele Guerini, Giuseppina De Marco, Vitaliana De Sanctis, Stefano Vagge, Umberto Ricardi and Gabriele Simontacchi

    Citation: Radiation Oncology 2020 15:62

    Content type: Review

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  30. To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protoco...

    Authors: Anna Sophie Duque, Stefanie Corradini, Florian Kamp, Max Seidensticker, Florian Streitparth, Christopher Kurz, Franziska Walter, Katia Parodi, Frank Verhaegen, Jens Ricke, Claus Belka, Gabriel Paiva Fonseca and Guillaume Landry

    Citation: Radiation Oncology 2020 15:60

    Content type: Research

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  31. Limiting the heart dose in left sided breast cancer radiotherapy is critical. We sought to study the effect of using CPAP (continuous positive airway pressure) as an aid in reducing heart dose in breast cancer...

    Authors: Aaron M. Allen, Yasmin Korzets Ceder, Tzippy Shochat, Eyal Fenig, Aron Popovtzer, Dimitry Bragilofsky, Adi Alfassy and Helena Allon

    Citation: Radiation Oncology 2020 15:59

    Content type: Research

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  32. Sublethal radiation induces matrix metalloproteinase 9 (MMP-9)-mediated radioresistance in Lewis lung carcinoma (LLC) cells and their metastatic dissemination. We aim to determine if EGFR/HER2 activation assoc...

    Authors: Yun Tien, Chiao-Ling Tsai, Wei-Hsien Hou, Yun Chiang, Feng-Ming Hsu, Yu-Chieh Tsai and Jason Chia-Hsien Cheng

    Citation: Radiation Oncology 2020 15:58

    Content type: Research

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  33. To quantify tumor anatomic change of non-small cell lung cancer (NSCLC) patients given passive-scattering proton therapy (PSPT) and intensity-modulated radiation therapy (IMRT) through 6–7 weeks of treatment, ...

    Authors: Mei Chen, Jinzhong Yang, Zhongxing Liao, Jiayi Chen, Cheng Xu, Xiaodong He, Xiaodong Zhang, Ronald X. Zhu and Heng Li

    Citation: Radiation Oncology 2020 15:55

    Content type: Research

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  34. The internal target volume (ITV) approach and the mid-ventilation (MidV) concept are the two main respiratory motion-management strategies under free breathing. The purpose of this work was to compare the actu...

    Authors: J. Bellec, F. Arab-Ceschia, J. Castelli, C. Lafond and E. Chajon

    Citation: Radiation Oncology 2020 15:54

    Content type: Research

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  35. The aim of the present study was to evaluate MRI response rate and clinical outcome of short-course radiotherapy (SCRT) on rectal cancer as an alternative to chemoradiotherapy in patients where downstaging is ...

    Authors: T. Koëter, S. G. C. van Elderen, G. F. A. J. B. van Tilborg, J. H. W. de Wilt, D. K. Wasowicz, T. Rozema and D. D. E. Zimmerman

    Citation: Radiation Oncology 2020 15:53

    Content type: Research

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  36. Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we ar...

    Authors: Konstantin Christoph Koban, Lucas Etzel, Zhouxiao Li, Montserrat Pazos, Stephan Schönecker, Claus Belka, Riccardo Enzo Giunta, Thilo Ludwig Schenck and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:52

    Content type: Research

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  37. For stereotactic body radiotherapy (SBRT) to central (C) and ultracentral (UC) lung tumors, our provincial practice has been to prioritize organs at risk (OARs) constraints by compromising target volume covera...

    Authors: Yizhou Zhao, Eman Khawandanh, Steven Thomas, Susan Zhang, Emma M. Dunne, Mitchell Liu and Devin Schellenberg

    Citation: Radiation Oncology 2020 15:61

    Content type: Research

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  38. Neoadjuvant radiotherapy (RT) has been shown to improve local control; however, whether it can improve overall survival (OS) in locally advanced rectal cancer (LARC) patients remains controversial. We therefor...

    Authors: Feng Zhao, Jili Wang, Hao Yu, Xiaofei Cheng, Xinke Li, Xuan Zhu, Xiangming Xu, Jianjiang Lin, Xin Chen and Senxiang Yan

    Citation: Radiation Oncology 2020 15:49

    Content type: Research

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  39. The literature regarding pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy (IMRT) for esophageal cancer was lacking. This study aimed to investigate the risk fa...

    Authors: Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng and Forn-Chia Lin

    Citation: Radiation Oncology 2020 15:48

    Content type: Research

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  40. To investigate the consequences of residual setup error on target dose distribution using various image registration strategies for breast cancer treated with intensity-modulated proton therapy (IMPT).

    Authors: Xiaoying Liang, Raymond B. Mailhot Vega, Zuofeng Li, Dandan Zheng, Nancy Mendenhall and Julie A. Bradley

    Citation: Radiation Oncology 2020 15:47

    Content type: Research

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  41. To analyze patterns of failure in patients with LA-NSCLC who received definitive chemoradiotherapy (CRT) and to build a nomogram for predicting the failure patterns in this population of patients.

    Authors: Xueru Zhu, Runping Hou, Xiaoyang Li, Chang Jiang, Wuyan Xia and Xiaolong Fu

    Citation: Radiation Oncology 2020 15:43

    Content type: Research

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  42. Although whole brain radiation therapy (WBRT) provides palliation and prophylaxis, reduces local recurrence probability and improves overall survival, it is evident that WBRT is associated with neurocognitive ...

    Authors: Adams Hei Long Yuen, Po Man Wu, Alex Kai Leung Li and Philip Chung Yin Mak

    Citation: Radiation Oncology 2020 15:42

    Content type: Research

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  43. The STAR-TReC trial is an international multi-center, randomized, phase II study assessing the feasibility of short-course radiotherapy or long-course chemoradiotherapy as an alternative to total mesorectal ex...

    Authors: Roy P. J. van den Ende, Femke P. Peters, Ernst Harderwijk, Heidi Rütten, Liza Bouwmans, Maaike Berbee, Richard A. M. Canters, Georgiana Stoian, Kim Compagner, Tom Rozema, Mariska de Smet, Martijn P. W. Intven, Rob H. N. Tijssen, Jacqueline Theuws, Paul van Haaren, Baukelien van Triest…

    Citation: Radiation Oncology 2020 15:41

    Content type: Research

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  44. On the elastic profiles of human teeth after radiotherapy for head and neck cancers, generation of dental complications, which may bring several side effects preventing the quality of life, has not well clarif...

    Authors: Irem Demirkan, Gokhan Yaprak, Cemile Ceylan, Emriye Algul, Ceyda Ozcakir Tomruk, Bukem Bilen and Mehmet Burcin Unlu

    Citation: Radiation Oncology 2020 15:38

    Content type: Research

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  45. There is limited data on the use of targeted or immunotherapy (TT/IT) in combination with single fraction stereotactic radiosurgery (SRS) in patients with melanoma brain metastasis (MBM). Therefore, we analyze...

    Authors: Indrawati Hadi, Olarn Roengvoraphoj, Raphael Bodensohn, Jan Hofmaier, Maximilian Niyazi, Claus Belka and Silke Birgit Nachbichler

    Citation: Radiation Oncology 2020 15:37

    Content type: Research

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  46. The development of radiation pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT) is known to be associated with many different factors, although historical analyses of RP have commonly utilized hetero...

    Authors: Jeffrey M. Ryckman, Michael Baine, Joseph Carmicheal, Ferdinand Osayande, Richard Sleightholm, Kaeli Samson, Dandan Zheng, Weining Zhen, Chi Lin and Chi Zhang

    Citation: Radiation Oncology 2020 15:33

    Content type: Research

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