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  1. Radiotherapy (RT) is applied in 45–60% of all cancer patients either alone or in multimodal therapy concepts comprising surgery, RT and chemotherapy. However, despite technical innovations approximately only 5...

    Authors: Kexu Xiang, Verena Jendrossek and Johann Matschke

    Citation: Radiation Oncology 2020 15:197

    Content type: Review

    Published on:

  2. Patients with resected oral cavity squamous cell carcinoma (OCSCC) are often treated with adjuvant radiation (RT) ± concomitant chemotherapy based on pathological findings. Standard RT volumes include all surg...

    Authors: Pencilla Lang, Jessika Contreras, Noah Kalman, Claire Paterson, Houda Bahig, Astrid Billfalk-Kelly, Sinead Brennan, Kathy Rock, Nancy Read, Varagur Venkatesan, Jinka Sathya, Lucas C. Mendez, S. Danielle MacNeil, Anthony C. Nichols, Kevin Fung, Adrian Mendez…

    Citation: Radiation Oncology 2020 15:196

    Content type: Study protocol

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  3. Hepatocellular carcinoma (HCC) involving a major branch of the portal or hepatic vein is in a locally advanced stage and remains difficult to cure. This study aimed to evaluate the clinical effects of carbon i...

    Authors: Shintaro Shiba, Kei Shibuya, Masahiko Okamoto, Shohei Okazaki, Shuichiro Komatsu, Yoshiki Kubota, Takashi Nakano and Tatsuya Ohno

    Citation: Radiation Oncology 2020 15:195

    Content type: Research

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  4. We sought to investigate the prognostic impact of missed RT sessions in patients who had undergone surgery for oral cavity squamous cell carcinoma (OCSCC).

    Authors: Yin-Yin Chiang, Yung-Chih Chou, Kai-Ping Chang, Chun-Ta Liao, Yao-Yu Wu, Wing-Keen Yap, Ping-Ching Pai, Joseph Tung-Chieh Chang, Chien-Yu Lin, Kang-Hsing Fan, Bing-Shen Huang, Tsung-Min Hung and Ngan-Ming Tsang

    Citation: Radiation Oncology 2020 15:194

    Content type: Research

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  5. This study was an open-label, 2-arms, monocentric, randomized clinical trial comparing Xonrid®, a topical medical device, versus standard of care (SOC) in preventing and treating acute radiation dermatitis (AR...

    Authors: Rossana Ingargiola, Maria Carmen De Santis, Nicola Alessandro Iacovelli, Nadia Facchinetti, Anna Cavallo, Eliana Ivaldi, Michela Dispinzieri, Marzia Franceschini, Carlotta Giandini, Domenico Attilio Romanello, Simona Di Biaso, Michela Sabetti, Laura Locati, Salvatore Alfieri, Paolo Bossi, Mauro Guglielmo…

    Citation: Radiation Oncology 2020 15:193

    Content type: Research

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  6. To develop a low-dose cone beam CT (LD-CBCT) reconstruction method named simultaneous algebraic reconstruction technique and dual-dictionary learning (SART-DDL) joint algorithm for image guided radiation thera...

    Authors: Ying Song, Weikang Zhang, Hong Zhang, Qiang Wang, Qing Xiao, Zhibing Li, Xing Wei, Jialu Lai, Xuetao Wang, Wan Li, Quan Zhong, Pan Gong, Renming Zhong and Jun Zhao

    Citation: Radiation Oncology 2020 15:192

    Content type: Research

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  7. Coronavirus Disease 2019 (COVID-19) pandemic had an overwhelming impact on healthcare worldwide. Outstandingly, the aftermath on neoplastic patients is still largely unknown, and only isolated cases of COVID-1...

    Authors: Michela Buglione, Luigi Spiazzi, Andrea Emanuele Guerini, Fernando Barbera, Nadia Pasinetti, Ludovica Pegurri, Luca Triggiani, Davide Tomasini, Diana Greco, Gianluca Costantino, Alessandra Bragaglio, Nadia Bonometti, Mara Liccioli, Lorella Mascaro, Filippo Alongi and Stefano Maria Magrini

    Citation: Radiation Oncology 2020 15:191

    Content type: Research

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  8. Intensity-modulated re-radiotherapy (reIMRT) has been established as a standard local treatment option in patients with non-resectable, recurrent head and neck cancer (rHNC). However, the clinical outcome is u...

    Authors: Thomas Held, Kristin Lang, Sebastian Regnery, Katharina Weusthof, Adriane Hommertgen, Cornelia Jäkel, Eric Tonndorf-Martini, Johannes Krisam, Peter Plinkert, Karim Zaoui, Christian Freudlsperger, Julius Moratin, Jürgen Krauss, Semi B. Harrabi, Klaus Herfarth, Jürgen Debus…

    Citation: Radiation Oncology 2020 15:190

    Content type: Study protocol

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  9. Pancreatic ductal adenocarcinoma (PDAC) is an extremely challenging disease with a high mortality rate and a short overall survival time. The poor prognosis can be explained by aggressive tumor growth, late di...

    Authors: Q. Li, S. H. Maier, P. Li, J. Peterhansl, C. Belka, J. Mayerle and U. M. Mahajan

    Citation: Radiation Oncology 2020 15:189

    Content type: Review

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  10. To investigate the feasibility of a knowledge-based automated intensity-modulated radiation therapy (IMRT) planning technique for locally advanced nasopharyngeal carcinoma (NPC) radiotherapy.

    Authors: Penggang Bai, Xing Weng, Kerun Quan, Jihong Chen, Yitao Dai, Yuanji Xu, Fasheng Lin, Jing Zhong, Tianming Wu and Chuanben Chen

    Citation: Radiation Oncology 2020 15:188

    Content type: Research

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  11. The growing acceptance and recognition of Surface Guided Radiation Therapy (SGRT) as a promising imaging technique has supported its recent spread in a large number of radiation oncology facilities. Although t...

    Authors: P. Freislederer, M. Kügele, M. Öllers, A. Swinnen, T.-O. Sauer, C. Bert, D. Giantsoudi, S. Corradini and V. Batista

    Citation: Radiation Oncology 2020 15:187

    Content type: Review

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    The Correction to this article has been published in Radiation Oncology 2020 15:244

  12. Leptomeningeal metastasis (LM) is a rare but detrimental complication in patients with non-small cell lung cancer (NSCLC). Although whole brain radiotherapy (WBRT) is used to eliminating cancer cells or micros...

    Authors: Junjie Zhen, Lei Wen, Mingyao Lai, Zhaoming Zhou, Changguo Shan, Shaoqun Li, Tao Lin, Jie Wu, Wensheng Wang, Shaoqiang Xu, Da Liu, Ming Lu, Dan Zhu, Longhua Chen, Linbo Cai and Cheng Zhou

    Citation: Radiation Oncology 2020 15:185

    Content type: Research

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  13. To identify the association between somatic ataxia-telangiectasia mutated (ATM) mutations and improved radio-sensitivity, we retrospectively reviewed next-generation sequencing data from patients diagnosed with i...

    Authors: Nalee Kim, Se Hoon Kim, Seok-Gu Kang, Ju Hyung Moon, Jaeho Cho, Chang-Ok Suh, Hong In Yoon and Jong Hee Chang

    Citation: Radiation Oncology 2020 15:184

    Content type: Research

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  14. We present a functional gene association network of the CLIP2 gene, generated by de-novo reconstruction from transcriptomic microarray data. CLIP2 was previously identified as a potential marker for radiation ind...

    Authors: Martin Selmansberger, Agata Michna, Herbert Braselmann, Ines Höfig, Kenji Schorpp, Peter Weber, Natasa Anastasov, Horst Zitzelsberger, Julia Hess and Kristian Unger

    Citation: Radiation Oncology 2020 15:182

    Content type: Research

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  15. Automatic tumor segmentation based on Convolutional Neural Networks (CNNs) has shown to be a valuable tool in treatment planning and clinical decision making. We investigate the influence of 7 MRI input channe...

    Authors: Lars Bielak, Nicole Wiedenmann, Arnie Berlin, Nils Henrik Nicolay, Deepa Darshini Gunashekar, Leonard Hägele, Thomas Lottner, Anca-Ligia Grosu and Michael Bock

    Citation: Radiation Oncology 2020 15:181

    Content type: Research

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  16. To test the efficacy and feasibility of pelvic bone marrow sparing intensity modulated radiotherapy (PBMS-IMRT) in reducing grade 2 or higher hematological toxicity (HT2+) for patients with cervical cancer tre...

    Authors: Jin Huang, Fei Gu, Tianlong Ji, Jing Zhao and Guang Li

    Citation: Radiation Oncology 2020 15:180

    Content type: Research

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  17. Locally recurrent rectal cancer (LRRC) after surgery or external beam radiotherapy (EBRT) is a serious challenge for which no standard treatment is defined. In the present study, we investigated the feasibilit...

    Authors: Lu Wang, Hao Wang, Yuliang Jiang, Zhe Ji, Fuxin Guo, Ping Jiang, Xuemin Li, Yi Chen, Haitao Sun, Jinghong Fan, Weiyan Li, Xu Li and Junjie Wang

    Citation: Radiation Oncology 2020 15:179

    Content type: Research

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  18. The assessment of organ motion is a crucial feature for prostate stereotactic body radiotherapy (SBRT). Rectal spacer may represent a helpful device in order to outdistance rectal wall from clinical target, bu...

    Authors: Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Vanessa Figlia, Niccolò Giaj-Levra, Francesco Ricchetti, Michele Rigo, Claudio Vitale, Beatrice Mantoan, Antonio De Simone, Gianluisa Sicignano, Ruggero Ruggieri, Stefano Cavalleri and Filippo Alongi

    Citation: Radiation Oncology 2020 15:178

    Content type: Research

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  19. Chronic encapsulated intracerebral hematomas (CEIHs) are a rare, late complication of radiosurgery for intracranial AVM. We present 5 cases treated mostly by surgical excision and review the literature.

    Authors: Stephanos Finitsis, Valerie Bernier, Isabelle Buccheit, Olivier Klein, Serge Bracard, Francois Zhu, Guillaume Gauchotte and René Anxionnat

    Citation: Radiation Oncology 2020 15:177

    Content type: Research

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  20. Impaired function of masticatory muscles will lead to trismus. Routine delineation of these muscles during planning may improve dose tracking and facilitate dose reduction resulting in decreased radiation-rela...

    Authors: Wen Chen, Yimin Li, Brandon A. Dyer, Xue Feng, Shyam Rao, Stanley H. Benedict, Quan Chen and Yi Rong

    Citation: Radiation Oncology 2020 15:176

    Content type: Research

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  21. Total scalp irradiation presents technical and dosimetric challenges. While reports suggest that HyperArc, a new stereotactic radiosurgery planning technique applied to non-coplanar volumetric-modulated arc th...

    Authors: Shoki Inui, Yoshihiro Ueda, Shingo Ohira, Haruhi Tsuru, Masaru Isono, Masayoshi Miyazaki, Masahiko Koizumi and Teruki Teshima

    Citation: Radiation Oncology 2020 15:175

    Content type: Research

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  22. Lentigo maligna (LM) is the most common subtype of in situ melanoma und occurs frequently in the sun-exposed head and neck region in elderly patients. The therapeutic “gold standard” is surgical excision, as t...

    Authors: Alexandra Hendrickx, Antonio Cozzio, Ludwig Plasswilm and Cédric M. Panje

    Citation: Radiation Oncology 2020 15:174

    Content type: Review

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  23. The use of stereotactic body radiotherapy (SBRT) as the primary treatment modality in clinically localized prostate cancer (PCa) is emerging. The aim of the study was to analyze the long-term results of PCa pa...

    Authors: Kristiina Vuolukka, Päivi Auvinen, Erno Tiainen, Jan-Erik Palmgren, Janne Heikkilä, Jan Seppälä, Sirpa Aaltomaa and Vesa Kataja

    Citation: Radiation Oncology 2020 15:173

    Content type: Research

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  24. This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework include...

    Authors: E. J. Her, A. Haworth, H. M. Reynolds, Y. Sun, A. Kennedy, V. Panettieri, M. Bangert, S. Williams and M. A. Ebert

    Citation: Radiation Oncology 2020 15:172

    Content type: Research

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  25. To date, only limited magnetic resonance imaging (MRI) data are available concerning tumor regression during neoadjuvant radiochemotherapy (RCT) of rectal cancer patients, which is a prerequisite for adaptive ...

    Authors: T. Bostel, C. Dreher, D. Wollschläger, A. Mayer, F. König, S. Bickelhaupt, H. P. Schlemmer, P. E. Huber, F. Sterzing, P. Bäumer, J. Debus and N. H. Nicolay

    Citation: Radiation Oncology 2020 15:171

    Content type: Research

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  26. Surface-guided radiation therapy (SGRT) employs a non-invasive real-time optical surface imaging (OSI) technique for patient surface motion monitoring during radiotherapy. The main purpose of this study is to ...

    Authors: Li Chen, Sen Bai, Guangjun Li, Zhibin Li, Qing Xiao, Long Bai, Changhu Li, Lixun Xian, Zhenyao Hu, Guyu Dai and Guangyu Wang

    Citation: Radiation Oncology 2020 15:170

    Content type: Research

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  27. Many dose calculation algorithms for radiotherapy planning need to be configured for each clinical beam using pre-defined measurements. An optimization process adjusts the physical parameters able to estimate ...

    Authors: A. Fogliata, E. Esposito, L. Paganini, G. Reggiori, S. Tomatis, M. Scorsetti and L. Cozzi

    Citation: Radiation Oncology 2020 15:169

    Content type: Research

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  28. The purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (M...

    Authors: Annika Mannerberg, Emilia Persson, Joakim Jonsson, Christian Jamtheim Gustafsson, Adalsteinn Gunnlaugsson, Lars E. Olsson and Sofie Ceberg

    Citation: Radiation Oncology 2020 15:168

    Content type: Research

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  29. Immune-checkpoint inhibitors (ICI) have dramatically changed the landscape of lung cancer treatment. Preclinical studies investigating combination of ICI with radiation show a synergistic improvement of tumor ...

    Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner, Olarn Roengvoraphoj, Maurice Dantes, Nina-Sophie Schmidt-Hegemann, Sanziana Schiopu, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:167

    Content type: Review

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  30. Starting in December 2019, the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confronts the world with an unprecedented challenge. With no vaccine or drug being cur...

    Authors: Sebastian Marschner, Stefanie Corradini, Josefine Rauch, Richard Zacharias, Ana Sujic, Julia Mayerle, Raluca Petru, Béatrice Grabein, Oliver T. Keppler, Edwin Boelke, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2020 15:165

    Content type: Research

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  31. To evaluate dosimetric differences of salvage irradiations using two commercially available volumetric modulated arc therapy (VMAT) stereotactic body radiation therapy (SBRT) techniques: RapidArc (RA) and Hype...

    Authors: Hsiu-Wen Ho, Steve P. Lee, Hisu-Man Lin, Hsiao-Yun Chen, Chun-Chiao Huang, Shih-Chang Wang, Ching-Chieh Yang and Yu-Wei Lin

    Citation: Radiation Oncology 2020 15:164

    Content type: Research

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  32. To explore the efficacy and sensitivity of 3D gamma analysis and bio-mathematical model for cervical cancer in detecting dose changes caused by dose-calculation-grid-size (DCGS).

    Authors: Han Bai, Sijin Zhu, Xingrao Wu, Xuhong Liu, Feihu Chen and Jiawen Yan

    Citation: Radiation Oncology 2020 15:161

    Content type: Research

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  33. Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton radiotherapy in treating hepatocellular carcinoma (HCC). However, cl...

    Authors: Jen-Yu Cheng, Chieh-Min Liu, Yu-Ming Wang, Hsuan-Chih Hsu, Eng-Yen Huang, Tzu-Ting Huang, Ching-Hsin Lee, Sheng-Ping Hung and Bing-Shen Huang

    Citation: Radiation Oncology 2020 15:159

    Content type: Research

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  34. Postoperative radiation therapy for soft tissue sarcomas demonstrated good local recurrence-free survival rates and survival outcomes. However, the results remained controversial. This study aimed to evaluate ...

    Authors: Xinmiao Yang, Lihua Zhang, Xiaojing Yang, Weiwei Yu and Jie Fu

    Citation: Radiation Oncology 2020 15:158

    Content type: Review

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  35. The purpose of this study was to determine the potential of escalated dose radiation (EDR) robust intensity-modulated proton radiotherapy (ro-IMPT) in reducing GI toxicity risk in locally advanced unresectable...

    Authors: Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano and Tetsuo Akimoto

    Citation: Radiation Oncology 2020 15:157

    Content type: Research

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  36. The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory o...

    Authors: Yun-Hsuan Lin, Shih-Ming Huang, Wing-Keen Yap, Ju-Wen Yang, Ling Yeung, Din-Li Tsan, Joseph Tung-Chieh Chang and Lung-Chien Chen

    Citation: Radiation Oncology 2020 15:156

    Content type: Research

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  37. The objectives of this study were to determine the objective effective response rate, survival, and safety of radiotherapy combined with gefitinib in patients with locally advanced non-small cell lung cancer (...

    Authors: Zhixue Fu, Xu Yang, Wenqing Wang, Lei Deng, Tao Zhang, Nan Bi, Xiaozhen Wang, Dongfu Chen, Zongmei Zhou, Luhua Wang and Jun Liang

    Citation: Radiation Oncology 2020 15:155

    Content type: Research

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  38. Healthcare workers occupationally exposed to 18F-FDG cannot wear protective equipment, such as lead aprons, since the interaction between high energy radiation (511 keV) and metal increases the dose of radiation ...

    Authors: Nilson Benedito Lopes, Igor Vivian Almeida, Pedro Henrique Silvestre Lopes and Veronica Elisa Pimenta Vicentini

    Citation: Radiation Oncology 2020 15:154

    Content type: Research

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  39. Even though frequent, it is not known how HIV infection and treatment impact in the consolidation by radiotherapy of non-Hodgkin diffuse large B-cell lymphomas (DBCL). This article aim to assess that differenc...

    Authors: Carolina Trindade Mello Medici, Geovanne Pedro Mauro, Lucas Coelho Casimiro and Eduardo Weltman

    Citation: Radiation Oncology 2020 15:153

    Content type: Research

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  40. Internal Target Volume (ITV) is one of the most common strategies to passively manage tumour motion in Radiotherapy (RT).

    Authors: Davide Cusumano, Jennifer Dhont, Luca Boldrini, Giuditta Chiloiro, Angela Romano, Claudio Votta, Silvia Longo, Lorenzo Placidi, Luigi Azario, Marco De Spirito, Dirk Verellen and Vincenzo Valentini

    Citation: Radiation Oncology 2020 15:152

    Content type: Research

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  41. Chemoradiotherapy remains the standard of care for locally advanced rectal cancer. Efforts to intensify treatment and increase response rates have yet to yield practice changing results due to increased toxici...

    Authors: Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan and Maria A. Hawkins

    Citation: Radiation Oncology 2020 15:151

    Content type: Study protocol

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  42. Retrospective analysis of volumetric modulated arc therapy treatment plans to investigate qualitative, possible, clinical consequences of the use of AAA versus AXB in nasopharyngeal cancer (NPC) cases.

    Authors: Antonella Bufacchi, Orietta Caspiani, Giulia Rambaldi, Luca Marmiroli, Giuseppe Giovinazzo and Mattia Polsoni

    Citation: Radiation Oncology 2020 15:150

    Content type: Research

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  43. Optimal alignment is of utmost importance when treating pediatric patients with craniospinal irradiation (CSI), especially with regards to field junctions and multiple isocenters and techniques applying high d...

    Authors: Daniel Gram, André Haraldsson, N. Patrik Brodin, Karsten Nysom, Thomas Björk-Eriksson and Per Munck af Rosenschöld

    Citation: Radiation Oncology 2020 15:149

    Content type: Research

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  44. Loco-regional and distant failure are common in inoperable stage III non small-cell lung cancer (NSCLC) after chemoradiotherapy (CRT). However, there is limited real-world data on failure pattern, patient prog...

    Authors: Julian Taugner, Chukwuka Eze, Lukas Käsmann, Olarn Roengvoraphoj, Kathrin Gennen, Monika Karin, Oleg Petrukhnov, Amanda Tufman, Claus Belka and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:148

    Content type: Research

    Published on:

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