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  1. Content type: Research

    The radiation transmission through the multileaf collimators is undesired in modern techniques such as volumetric modulated arc therapy (VMAT). According to identical plans, in this study, we aim to investigat...

    Authors: Kai Xie, Hongfei Sun, Liugang Gao, Tao Lin, Jianfeng Sui and Xinye Ni

    Citation: Radiation Oncology 2019 14:75

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  2. Content type: Research

    The impact of sex on prognosis of patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. The present study aimed to determine the impact of sex on the prog...

    Authors: He-San Luo, Hong-Yao Xu, Ze-Sen Du, Xu-Yuan Li, Sheng-Xi Wu, He-Cheng Huang and Lian-Xing Lin

    Citation: Radiation Oncology 2019 14:74

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  3. Content type: Research

    To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol.

    Authors: Sotirios Katsigiannis, Boris Krischek, Stefanie Barleanu, Stefan Grau, Norbert Galldiks, Marco Timmer, Christoph Kabbasch, Roland Goldbrunner and Pantelis Stavrinou

    Citation: Radiation Oncology 2019 14:73

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  4. Content type: Research

    An objective way to qualify the effect of radiotherapy (RT) on lung tissue is the analysis of CT scans after RT. In this analysis we focused on the changes in Hounsfield units (ΔHU) and the correlation with th...

    Authors: Christina Schröder, Rita Engenhart-Cabillic, Sven Kirschner, Eyck Blank and André Buchali

    Citation: Radiation Oncology 2019 14:72

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  5. Content type: Review

    Different studies have proved in recent years that hypofractionated radiotherapy (RT) improves overall survival of patients affected by locally advanced, unresectable, pancreatic cancer.

    Authors: Luca Boldrini, Davide Cusumano, Francesco Cellini, Luigi Azario, Gian Carlo Mattiucci and Vincenzo Valentini

    Citation: Radiation Oncology 2019 14:71

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  6. Content type: Research

    In this study, an external 8 mm thick aluminum target was installed on the upper accessory tray mount of a medical linear accelerator head. The purpose of this study was to determine the effects of the externa...

    Authors: Jonggeun Baek, Hyungdong Kim, Byungyong Kim, Youngkee Oh and Hyunsoo Jang

    Citation: Radiation Oncology 2019 14:70

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  7. Content type: Research

    Intraductal carcinoma of the prostate (IDC-P) is an independent biomarker of recurrence and survival with particular treatment response, yet no study has tested its response to radiotherapy. The aim of our pro...

    Authors: Vincent Q. Trinh, Nazim Benzerdjeb, Ségolène Chagnon-Monarque, Nicolas Dionne, Guila Delouya, André Kougioumoutzakis, Jennifer Sirois, Roula Albadine, Mathieu Latour, Anne-Marie Mes-Masson, Hélène Hovington, Alain Bergeron, Kevin C. Zorn, Yves Fradet, Fred Saad, Daniel Taussky…

    Citation: Radiation Oncology 2019 14:60

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  8. Content type: Research

    The aim was to evaluate the outcome, especially locoregional control of patients with locally advanced salivary gland carcinoma (SGC) with perineural spread (Pn1) and/or positive resection margins (R1/2) after...

    Authors: Marlen Haderlein, Claudia Scherl, Sabine Semrau, Sebastian Lettmaier, Markus Hecht, Florian Putz, Heinrich Iro, Abbas Agaimy and Rainer Fietkau

    Citation: Radiation Oncology 2019 14:68

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  9. Content type: Research

    Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Th...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Marcus Feith, Helmut Friess, Wilko Weichert, Moritz Jesinghaus, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:66

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  10. Content type: Research

    The differential diagnosis between radiation necrosis, tumor recurrence and tumor progression is crucial for the evaluation of treatment response and treatment planning.

    Authors: Rosa Morabito, Concetta Alafaci, Stefano Pergolizzi, Antonio Pontoriero, Giuseppe Iati’, Lilla Bonanno, Michele Gaeta, Francesco Maria Salpietro, Enricomaria Mormina, Marcello Longo and Francesca Granata

    Citation: Radiation Oncology 2019 14:65

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  11. Content type: Research

    Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation b...

    Authors: Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray and David Argyle

    Citation: Radiation Oncology 2019 14:64

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  12. Content type: Research

    Patients with plasma-cell neoplasia usually suffer from systemic disease, although a minority (< 5%) may present with solitary involvement of bone or soft tissue (extramedullary plasmacytoma (EMP)). Radiothera...

    Authors: Michael Oertel, Khaled Elsayad, Kai Jannes Kroeger, Uwe Haverkamp, Claudia Rudack, Georg Lenz and Hans Theodor Eich

    Citation: Radiation Oncology 2019 14:63

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  13. Content type: Research

    To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator.

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Tomohiro Ono, Hiraku Iramina and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:62

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  14. Content type: Research

    This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

    Authors: Chih-Jen Huang, Ming-Yii Huang, Ming-Chen Paul Shih, Kai-yuan Cheng, Ka-Wo Lee, Tzu-Ying Lu, Shyng-Shiou Yuan and Pen-Tzu Fang

    Citation: Radiation Oncology 2019 14:61

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  15. Content type: Research

    Although there have been many attempts to increase the therapeutic ratio of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma (MALToma), only a few planning studies have reported the efficacy...

    Authors: Seo Hee Choi, So Hyun Park, Jason Joon Bock Lee, Jong Geol Baek, Jin Sung Kim and Hong In Yoon

    Citation: Radiation Oncology 2019 14:59

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  16. Content type: Review

    Advanced pelvic radiotherapy techniques aim to reduce late bowel toxicity which can severely impact the lives of pelvic cancer survivors. Although advanced techniques have been largely adopted worldwide, to ac...

    Authors: Rashmi Jadon, Emma Higgins, Louise Hanna, Mererid Evans, Bernadette Coles and John Staffurth

    Citation: Radiation Oncology 2019 14:57

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  17. Content type: Research

    We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.

    Authors: Yeona Cho, Yoon Jin Cho, Won Suk Chang, Jun Won Kim, Won Hoon Choi and Ik Jae Lee

    Citation: Radiation Oncology 2019 14:56

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  18. Content type: Research

    It remains unknown which is the most preferable regimen used concurrently with thoracic radiation for locally advanced non-small cell lung cancer (NSCLC). We performed a network meta-analysis to address this i...

    Authors: Tingting Liu, Zheng He, Jun Dang and Guang Li

    Citation: Radiation Oncology 2019 14:55

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  19. Content type: Research

    To validate and propose revision of the 8th edition American Joint Committee on Cancer (AJCC) clinical staging system for esophageal squamous cell cancer (ESCC) patients treated with definitive intensity-modul...

    Authors: Mingqiu Chen, Xiqing Li, Yuangui Chen, Pingping Liu, Zhiwei Chen, Minmin Shen, Xiaohong Liu, Yu Lin, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Ye Tian, Junqiang Chen and Lengxi Fu

    Citation: Radiation Oncology 2019 14:54

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  20. Content type: Research

    To clarify the short- and long-term outcomes of radical surgery after neoadjuvant chemoradiotherapy (NCRT) with TS-1 and irinotecan, which enhances radiosensitivity, in patients with locally advanced rectal ca...

    Authors: Takatoshi Nakamura, Takeo Sato, Kazushige Hayakawa, Wasaburou Koizumi, Yuji Kumagai and Masahiko Watanabe

    Citation: Radiation Oncology 2019 14:53

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  21. Content type: Study protocol

    Few patients with pancreatic cancer may be candidates for immediate surgical resection at the initial diagnosis. Even if patients with borderline resectable pancreatic cancer (BRPC), micrometastases may occur ...

    Authors: Suizhi Gao, Xiaofei Zhu, Xiaohan Shi, Kai Cao, Yun Bian, Hui Jiang, Kaixuan Wang, Shiwei Guo, Huojun Zhang and Gang Jin

    Citation: Radiation Oncology 2019 14:52

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  22. Content type: Research

    Immunotherapy is currently being examined as a treatment modality for glioblastoma. Maintaining an optimal total lymphocyte count (TLC) after radiotherapy (RT) and using temozolomide may be beneficial in optim...

    Authors: Hwa Kyung Byun, Nalee Kim, Hong In Yoon, Seok-Gu Kang, Se Hoon Kim, Jaeho Cho, Jong Geol Baek, Jong Hee Chang and Chang-Ok Suh

    Citation: Radiation Oncology 2019 14:51

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  23. Content type: Research

    Child-Turcotte-Pugh (CTP) score extensively used to assess hepatic function, predicting postoperative outcome of hepatocellular carcinoma (HCC) patients. Lately, the albumin–bilirubin (ALBI) grade has been ide...

    Authors: Ting-Shi Su, Hai-Ming Yang, Ying Zhou, Yong Huang, Ping Liang, Tao Cheng, Long Chen, Le-Qun Li and Shi-Xiong Liang

    Citation: Radiation Oncology 2019 14:50

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  24. Content type: Research

    Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

    Authors: Katarina G. Petras, Alfred W. Rademaker, Tamer Refaat, Mehee Choi, Tarita O. Thomas, Barbara R. Pauloski and Bharat B. Mittal

    Citation: Radiation Oncology 2019 14:49

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  25. Content type: Research

    To investigate the safety and tolerability of simultaneous integrated boost (SIB) technique concurrent with elective nodal irradiation (ENI) and dual-drug chemotherapy for patients with unresectable esophageal...

    Authors: Chen Li, Wenjie Ni, Xin Wang, Zongmei Zhou, Wei Deng, Xiao Chang, Dongfu Chen, Qinfu Feng, Jun Liang, Xiaozhen Wang, Lei Deng, Wenqing Wang, Nan Bi, Tao Zhang and Zefen Xiao

    Citation: Radiation Oncology 2019 14:48

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  26. Content type: Research

    Rectal spacers are used to limit dose to the anterior rectal wall in high dose external beam radiation therapy of the prostate and have been shown to reduce radiation induced toxicity. Here we report the compl...

    Authors: Andreas Schörghofer, Martin Drerup, Thomas Kunit, Lukas Lusuardi, Josef Holzinger, Josef Karner, Michael Groher, Christoph Zoubek, Rosemarie Forstner, Felix Sedlmayer and Frank Wolf

    Citation: Radiation Oncology 2019 14:47

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  27. Content type: Research

    To perform a dosimetric evaluation of four different simultaneous integrated boost whole brain radiotherapy modalities with hippocampus and inner ear avoidance in the treatment of limited brain metastases.

    Authors: Aijun Jiang, Weipeng Sun, Fen Zhao, Zhenxuan Wu, Dongping Shang, Qingxi Yu, Suzhen Wang, Jian Zhu, Fengchang Yang and Shuanghu Yuan

    Citation: Radiation Oncology 2019 14:46

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  28. Content type: Research

    Administering stereotactic radiotherapy to the surgical cavity and thus omitting postoperative whole brain radiotherapy (WBRT) is a favored strategy in limited metastatic brain disease. Little is known about t...

    Authors: N. Bachmann, D. Leiser, E. Ermis, S. Vulcu, P. Schucht, A. Raabe, D. M. Aebersold and E. Herrmann

    Citation: Radiation Oncology 2019 14:45

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  29. Content type: Research

    Despite development of several next-generation tyrosine kinase inhibitors (TKIs), crizotinib remains one of the first-line treatment options for advanced ALK-positive NSCLC and is widely used in situations where ...

    Authors: Jianjiao Ni, Guodong Li, Xi Yang, Li Chu, Jialei Wang, Yida Li, Liqing Zou, Yuan Li, Congying Xie and Zhengfei Zhu

    Citation: Radiation Oncology 2019 14:44

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  30. Content type: Research

    To develop and compare delta-radiomics signatures from 2- (2D) and 3-dimensional (3D) features that predict treatment outcomes following preoperative chemoradiotherapy (CCRT) and surgery for locally advanced r...

    Authors: Seung Hyuck Jeon, Changhoon Song, Eui Kyu Chie, Bohyoung Kim, Young Hoon Kim, Won Chang, Yoon Jin Lee, Joo-Hyun Chung, Jin Beom Chung, Keun-Wook Lee, Sung-Bum Kang and Jae-Sung Kim

    Citation: Radiation Oncology 2019 14:43

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  31. Content type: Research

    To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

    Authors: Jiazhou Wang, Yibing Miao, Xiaomin Ou, Xiaoshen Wang, Xiayun He, Chunying Shen, Hongmei Ying, Weigang Hu and Chaosu Hu

    Citation: Radiation Oncology 2019 14:42

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  32. Content type: Research

    Radiotherapy plays a major role in the management of brain metastases. This study aimed to identify the subset of patients with multiple brain metastases who may not benefit from whole brain irradiation (WBI) ...

    Authors: Rebecca Buecker, Zhen-Yu Hong, Xiao-Mei Liu, Gert Jaenke, Ping Lu and Ulrich Schaefer

    Citation: Radiation Oncology 2019 14:41

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  33. Content type: Research

    To assess the relationship between radiation doses to the coronary arteries (CAs) and location of a coronary stenosis that required intervention after three-dimensional conformal radiotherapy (3DCRT) for breas...

    Authors: Anna-Karin Wennstig, Hans Garmo, Ulf Isacsson, Giovanna Gagliardi, Niina Rintelä, Bo Lagerqvist, Lars Holmberg, Carl Blomqvist, Malin Sund and Greger Nilsson

    Citation: Radiation Oncology 2019 14:40

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  34. Content type: Research

    Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL ...

    Authors: Julia Rupp, Catarina Hadamitzky, Christoph Henkenberens, Hans Christiansen, Diana Steinmann and Frank Bruns

    Citation: Radiation Oncology 2019 14:39

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  35. Content type: Research

    To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation i...

    Authors: Ting Yu, Jian Bin Li, Wei Wang, Min Xu, Ying Jie Zhang, Qian Shao, Xi Jun Liu and Liang Xu

    Citation: Radiation Oncology 2019 14:38

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  36. Content type: Research

    Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time...

    Authors: Maciej Harat, Bogdan Małkowski and Krzysztof Roszkowski

    Citation: Radiation Oncology 2019 14:37

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  37. Content type: Research

    Measurement-guided dose reconstruction has lately attracted significant attention because it can predict the delivered patient dose distribution. Although the treatment planning system (TPS) uses sophisticated...

    Authors: Akari Kaneko, Iori Sumida, Hirokazu Mizuno, Fumiaki Isohashi, Osamu Suzuki, Yuji Seo, Keisuke Otani, Keisuke Tamari and Kazuhiko Ogawa

    Citation: Radiation Oncology 2019 14:36

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  38. Content type: Research

    To evaluate the prognostic value of metabolic parameters of pre-treatment and interim 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for overall survival (OS) of esophageal cancer(EC) patients...

    Authors: Yimin Li, Sebastian Zschaeck, Qin Lin, Sijia Chen, Lili Chen and Hua Wu

    Citation: Radiation Oncology 2019 14:35

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  39. Content type: Research

    Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has ...

    Authors: Sati Akbaba, Thomas Held, Kristin Lang, Juliane Hoerner-Rieber, Karim Zaoui, Tobias Forster, Stefan Rieken, Peter Plinkert, Juergen Debus and Sebastian Adeberg

    Citation: Radiation Oncology 2019 14:34

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  40. Content type: Research

    Different management options exist for patients with brain metastases from non-small cell lung cancer (NSCLC), patients whose treatment with whole brain radiotherapy (WBRT) has become more controversial over t...

    Authors: Carsten Nieder, Matthias Guckenberger, Laurie E. Gaspar, Chad G. Rusthoven, Dirk De Ruysscher, Arjun Sahgal, Timothy Nguyen, Anca L. Grosu and Minesh P. Mehta

    Citation: Radiation Oncology 2019 14:33

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  41. Content type: Research

    Concurrent chemoradiotherapy with cisplatin is standard for patients (pts) with loco-regionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) and for patients with resected SCCHN with high-r...

    Authors: Seth Helfenstein, Oliver Riesterer, Urs R. Meier, Alexandros Papachristofilou, Benjamin Kasenda, Miklos Pless and Sacha I. Rothschild

    Citation: Radiation Oncology 2019 14:32

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  42. Content type: Research

    In patients with T4 nasopharyngeal carcinoma (NPC), death may occur prior to the occurrence of temporal lobe injury (TLI). Because such competing risk death precludes the occurrence of TLI and thus the competi...

    Authors: Juan Huang, Fang-fang Kong, Ronald Wihal Oei, Rui-ping Zhai, Chao-su Hu and Hong-mei Ying

    Citation: Radiation Oncology 2019 14:31

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  43. Content type: Research

    Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay e...

    Authors: Kai Dolde, Ye Zhang, Naved Chaudhri, Christian Dávid, Marc Kachelrieß, Antony John Lomax, Patrick Naumann, Nami Saito, Damien Charles Weber and Asja Pfaffenberger

    Citation: Radiation Oncology 2019 14:30

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  44. Content type: Research

    Intra-individual heterogeneity of cardiac exposure is an issue in breast cancer (BC) radiotherapy that was poorly considered in previous cardiotoxicity studies mainly based on mean heart dose (MHD). This dosim...

    Authors: Sophie Jacob, Jérémy Camilleri, Sylvie Derreumaux, Valentin Walker, Olivier Lairez, Mathieu Lapeyre, Eric Bruguière, Atul Pathak, Marie-Odile Bernier, Dominique Laurier, Jean Ferrieres, Olivier Gallocher, Igor Latorzeff, Baptiste Pinel, Denis Franck, Christian Chevelle…

    Citation: Radiation Oncology 2019 14:29

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  45. Content type: Review

    This systematic review aims to elucidate the diagnostic accuracy of radiological examinations to distinguish between brain radiation necrosis (BRN) and tumor progression (TP).

    Authors: Motomasa Furuse, Naosuke Nonoguchi, Kei Yamada, Tohru Shiga, Jean-Damien Combes, Naokado Ikeda, Shinji Kawabata, Toshihiko Kuroiwa and Shin-Ichi Miyatake

    Citation: Radiation Oncology 2019 14:28

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  46. Content type: Research

    The SCOPE trials (SCOPE 1, NeoSCOPE and SCOPE 2) have been the backbone of oesophageal RT trials in the UK. Many changes in oesophageal RT techniques have taken place in this time. The SCOPE trials have, in ad...

    Authors: S. Gwynne, E. Higgins, A. Poon King, G. Radhakrishna, L. Wills, S. Mukherjee, Maria Hawkins, G. Jones, J. Staffurth and T. Crosby

    Citation: Radiation Oncology 2019 14:26

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