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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. Despite dosimetric benefits of volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation (RNI), low dose to the thoracic structures rema...

    Authors: Vishruta A. Dumane, Kitwadee Saksornchai, Ying Zhou, Linda Hong, Simon Powell and Alice Y. Ho
    Citation: Radiation Oncology 2018 13:187
  2. A novel remote method for external dosimetric TPS-planned auditing of intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for clinical trials using electronic portal imaging dev...

    Authors: Narges Miri, Kimberley Legge, Kim Colyvas, Joerg Lehmann, Philip Vial, Alisha Moore, Monica Harris and Peter B. Greer
    Citation: Radiation Oncology 2018 13:178
  3. To measure the absorbed dose rate to water and penumbra of a Gamma Knife® (GK) using a polymethyl metacrylate (PMMA) phantom.

    Authors: Jae Pil Chung, Young Min Seong, Tae Yeon Kim, Yona Choi, Tae Hoon Kim, Hyun Joon Choi, Chul Hee Min, Hamza Benmakhlouf, Kook Jin Chun and Hyun-Tai Chung
    Citation: Radiation Oncology 2018 13:176
  4. Interfractional organ position variation might differ for abdominal organs and this could have consequences for defining safety margins. Therefore, the purpose of this study is to quantify interfractional posi...

    Authors: Sophie C. Huijskens, Irma W. E. M. van Dijk, Jorrit Visser, Brian V. Balgobind, D. te Lindert, Coen R. N. Rasch, Tanja Alderliesten and Arjan Bel
    Citation: Radiation Oncology 2018 13:173
  5. Automated treatment planning and/or optimization systems (ATPS) are in the process of broad clinical implementation aiming at reducing inter-planner variability, reducing the planning time allocated for the op...

    Authors: J. Krayenbuehl, M. Zamburlini, S. Ghandour, M. Pachoud, S. Tanadini-Lang, J. Tol, M. Guckenberger and W. F. A. R. Verbakel
    Citation: Radiation Oncology 2018 13:170

    The Correction to this article has been published in Radiation Oncology 2018 13:225

  6. Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective ...

    Authors: Yvonne Dzierma, Katharina Mikulla, Patrick Richter, Katharina Bell, Patrick Melchior, Frank Nuesken and Christian Rübe
    Citation: Radiation Oncology 2018 13:168
  7. Stereotactic Body Radiotherapy (SBRT) is an ablative dose delivery technique which requires the highest levels of precision and accuracy. Modeling dose to a lung treatment volume has remained a complex and cha...

    Authors: Dennis J. Mohatt, Tianjun Ma, David B. Wiant, Naveed M. Islam, Jorge Gomez, Anurag K. Singh and Harish K. Malhotra
    Citation: Radiation Oncology 2018 13:165
  8. A wide application of ultrasound for radiation therapy has been hindered by a few issues such as skin and target deformations due to probe pressure, optical tracking disabilities caused by irregular surfaces a...

    Authors: Heejung Kim, Ah Ram Chang, Sungwoo Cho and Sung-Joon Ye
    Citation: Radiation Oncology 2018 13:164
  9. This study clarified the mechanical performance of volumetric modulated arc therapy (VMAT) plans for prostate cancer generated with a commercial knowledge-based treatment planning (KBP) and whether KBP system ...

    Authors: Mikoto Tamura, Hajime Monzen, Kenji Matsumoto, Kazuki Kubo, Masakazu Otsuka, Masahiro Inada, Hiroshi Doi, Kazuki Ishikawa, Kiyoshi Nakamatsu, Iori Sumida, Hirokazu Mizuno, Do-Kun Yoon and Yasumasa Nishimura
    Citation: Radiation Oncology 2018 13:163
  10. The demand for dose verification during treatment has risen with the increasing use of intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in modern radiation therapy. This...

    Authors: So-Yeon Park, Jong Min Park, Jung-in Kim, Sungyoung Lee and Chang Heon Choi
    Citation: Radiation Oncology 2018 13:156
  11. Emerging hypofractionated prostate radiotherapy regimens require solutions for accurate target tracking during beam delivery. The goal of this study is to evaluate the performance of the Clarity ultrasound mon...

    Authors: Bin Han, Mohammad Najafi, David T. Cooper, Martin Lachaine, Rie von Eyben, Steven Hancock and Dimitre Hristov
    Citation: Radiation Oncology 2018 13:151
  12. Patient-specific distortions, particularly near tissue/air interfaces, require assessment for magnetic resonance (MR) only radiation treatment planning (RTP). However, patients are dynamic due to changes in ph...

    Authors: Carri Glide-Hurst, Siamak Nejad-Davarani, Steffen Weiss, Weili Zheng, Indrin J. Chetty and Steffen Renisch
    Citation: Radiation Oncology 2018 13:149
  13. The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the he...

    Authors: Ying Tong, Yong Yin, Pinjing Cheng and Guanzhong Gong
    Citation: Radiation Oncology 2018 13:145
  14. The software PRIMO for the Monte Carlo simulation of radiotherapy linacs could potentially act as a independent calculation system to verify the calculations of treatment planning systems. We investigated the ...

    Authors: Marcelino Hermida–López, David Sánchez–Artuñedo and Juan Francisco Calvo–Ortega
    Citation: Radiation Oncology 2018 13:144
  15. To evaluate the difference of absorbed doses calculated to medium and to water by a Monte Carlo (MC) algorithm based treatment planning system (TPS), and to assess the potential clinical impact to dose prescri...

    Authors: Li Chen, Botian Huang, Xiaoyan Huang, Wufei Cao, Wenzhao Sun and Xiaowu Deng
    Citation: Radiation Oncology 2018 13:137
  16. Linac output as a function of field sizes has a phantom and a head scatter component. This last term can be measured in-air with appropriate build-up ensuring a complete electron equilibrium and the absence of...

    Authors: A. Fogliata, A. Stravato, G. Reggiori, S. Tomatis, J. Würfel, M. Scorsetti and L. Cozzi
    Citation: Radiation Oncology 2018 13:126
  17. Better knowledge of the dose-toxicity relationship is essential for safe dose escalation to improve local control in cervical cancer radiotherapy. The conventional dose-toxicity model is based on the dose volu...

    Authors: Jiawei Chen, Haibin Chen, Zichun Zhong, Zhuoyu Wang, Brian Hrycushko, Linghong Zhou, Steve Jiang, Kevin Albuquerque, Xuejun Gu and Xin Zhen
    Citation: Radiation Oncology 2018 13:125
  18. The use of the Monte Carlo (MC) method in radiotherapy dosimetry has increased almost exponentially in the last decades. Its widespread use in the field has converted this computer simulation technique in a co...

    Authors: Pedro Andreo
    Citation: Radiation Oncology 2018 13:121
  19. Uncertainties associated with the delivery of treatment to moving organs might compromise the accuracy of treatment. This study explores the impact of intra-fractional anatomical changes in pancreatic patients...

    Authors: Vania Batista, Daniel Richter, Naved Chaudhri, Patrick Naumann, Klaus Herfarth and Oliver Jäkel
    Citation: Radiation Oncology 2018 13:120
  20. This is a dosimetric comparative study intended to establish appropriate low-to-intermediate dose-constraints for the rectal wall (Rwall) in the context of a randomized phase-II trial on urethra-sparing stereotac...

    Authors: Angèle Dubouloz, Michel Rouzaud, Lev Tsvang, Wilko Verbakel, Mikko Björkqvist, Nadine Linthout, Joana Lencart, Juan María Pérez-Moreno, Zeynep Ozen, Lluís Escude, Thomas Zilli and Raymond Miralbell
    Citation: Radiation Oncology 2018 13:114
  21. Ion beam radiotherapy provides potential for increased dose conformation to the target volume. To translate it into a clinical advantage, it is necessary to guarantee a precise alignment of the actual internal...

    Authors: M. Martišíková, T. Gehrke, S. Berke, G. Aricò and O. Jäkel
    Citation: Radiation Oncology 2018 13:109
  22. Prediction of radiobiological response is a major challenge in radiotherapy. Of several radiobiological models, the linear-quadratic (LQ) model has been best validated by experimental and clinical data. Clinic...

    Authors: C. M. van Leeuwen, A. L. Oei, J. Crezee, A. Bel, N. A. P. Franken, L. J. A. Stalpers and H. P. Kok
    Citation: Radiation Oncology 2018 13:96
  23. A new strategy for making the appropriate choice of the representative optimization parameters in planning processes and accurate selection criteria during Pareto surface navigation for general multicriteria o...

    Authors: Juanqi Wang, Zhi Chen, Weiwei Li, Wei Qian, Xiaosheng Wang and Weigang Hu
    Citation: Radiation Oncology 2018 13:94
  24. The principle aim of this study is to incorporate 4DCT ventilation imaging into functional treatment planning that preserves high-functioning lung with both double scattering and scanning beam techniques in pr...

    Authors: Qijie Huang, Salma K. Jabbour, Zhiyan Xiao, Ning Yue, Xiao Wang, Hongbin Cao, Yu Kuang, Yin Zhang and Ke Nie
    Citation: Radiation Oncology 2018 13:78
  25. Postoperative/adjuvant radiotherapy of advanced gastric cancer involves a large planning target volume (PTV) with multi-concave shapes which presents a challenge for volumetric modulated arc therapy (VMAT) pla...

    Authors: Abdul Wahab M. Sharfo, Florian Stieler, Oskar Kupfer, Ben J. M. Heijmen, Maarten L. P. Dirkx, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann and Daniel Buergy
    Citation: Radiation Oncology 2018 13:74
  26. During therapeutic beam irradiation, an unvisualized three-dimensional (3D) target position should be estimated using an external surrogate with an estimation model. Training periods for the developed model wi...

    Authors: Hiraku Iramina, Mitsuhiro Nakamura, Yusuke Iizuka, Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Mizowaki and Ikuo Kanno
    Citation: Radiation Oncology 2018 13:73
  27. To evaluate spot-scanning proton arc therapy (SPArc) and multi-field robust optimized intensity modulated proton therapy (RO-IMPT) in treating stage III non-small-cell lung cancer (NSCLC) patients.

    Authors: Xiaoqiang Li, Peyman Kabolizadeh, Di Yan, An Qin, Jun Zhou, Ye Hong, Thomas Guerrero, Inga Grills, Craig Stevens and Xuanfeng Ding
    Citation: Radiation Oncology 2018 13:35
  28. Tumor-Treating Fields (TTFields) are a novel treatment strategy for glioblastoma (GBM) that is approved for the use concomitantly to adjuvant chemotherapy. Preclinical data suggest a synergistic interaction of...

    Authors: Christoph Straube, Markus Oechsner, Severin Kampfer, Sophia Scharl, Friederike Schmidt-Graf, Jan J. Wilkens and Stephanie E. Combs
    Citation: Radiation Oncology 2018 13:31
  29. Volumetric-modulated Dynamic WaveArc therapy (VMDWAT) is a non-coplanar continuous volumetric modulated radiation therapy (VMAT) delivery technique. Here, we monitored mechanical errors and their impact on dos...

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Megumi Uto, Kiyonao Nakamura and Takashi Mizowaki
    Citation: Radiation Oncology 2018 13:27
  30. Whole-brain radiation therapy (WBRT) with hippocampus sparing (HS) has been investigated by the radiation oncology working group (RTOG) 0933 trial for patients with multiple brain metastases. They showed a dec...

    Authors: J. Krayenbuehl, M. Di Martino, M. Guckenberger and N. Andratschke
    Citation: Radiation Oncology 2017 12:161

    The Correction to this article has been published in Radiation Oncology 2017 12:173

  31. Recently developed stereotactic partial breast irradiation (S-PBI) allows delivery of a high biologically potent dose to the target while sparing adjacent critical organs and normal tissue. With S-PBI tumorici...

    Authors: Xin Zhen, Bo Zhao, Zhuoyu Wang, Robert Timmerman, Ann Spangler, Nathan Kim, Asal Rahimi and Xuejun Gu
    Citation: Radiation Oncology 2017 12:151
  32. The purpose of this study is to introduce the new concept of a four-dimensional (4D) cone-beam computed tomography (CBCT) reconstruction approach for non-periodic organ motion in cooperation with the time-orde...

    Authors: Masahiro Nakano, Akihiro Haga, Jun’ichi Kotoku, Taiki Magome, Yoshitaka Masutani, Shouhei Hanaoka, Satoshi Kida and Keiichi Nakagawa
    Citation: Radiation Oncology 2017 12:145
  33. The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion th...

    Authors: Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan and Wen-Chien Hsi
    Citation: Radiation Oncology 2017 12:132
  34. Osteosarcoma is the most frequent primary malignant bone tumour, and its incidence is higher in children and adolescents, for whom it represents more than 10% of solid cancers. Despite the introduction of adju...

    Authors: Silva Bortolussi, Ian Postuma, Nicoletta Protti, Lucas Provenzano, Cinzia Ferrari, Laura Cansolino, Paolo Dionigi, Olimpio Galasso, Giorgio Gasparini, Saverio Altieri, Shin-Ichi Miyatake and Sara J. González
    Citation: Radiation Oncology 2017 12:130
  35. Traditional CTV-PTV margin recipes are not generally applicable in the situation of stereotactic ablative radiotherapy (SABR) treatments of multiple target volumes with a single isocentre. In this work, we pre...

    Authors: Ciara A. Lyons, Raymond B. King, Sarah O.S. Osman, Stephen J. McMahon, Joe M. O’Sullivan, Alan R. Hounsell, Suneil Jain and Conor K. McGarry
    Citation: Radiation Oncology 2017 12:124
  36. To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients.

    Authors: Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos and Margie Hunt
    Citation: Radiation Oncology 2017 12:119
  37. Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to sta...

    Authors: Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss and Young Lee
    Citation: Radiation Oncology 2017 12:117
  38. The aim of this study was to investigate if the flattening filter free (FFF) irradiation mode of a linear accelerator (linac) is advantageous as compared to the flat beam (FF) irradiation mode in intensity mod...

    Authors: Barbara Dobler, Tina Obermeier, Matthias G. Hautmann, Amine Khemissi and Oliver Koelbl
    Citation: Radiation Oncology 2017 12:114
  39. In IGRT of deformable head-and-neck anatomy, patient setup corrections are derived by rigid registration methods. In practice, experienced radiation therapists often correct the resulting vectors, thus indicat...

    Authors: Eva Maria Stoiber, Nina Bougatf, Hendrik Teske, Christian Bierstedt, Dieter Oetzel, Jürgen Debus, Rolf Bendl and Kristina Giske
    Citation: Radiation Oncology 2017 12:104
  40. Respiration-correlated CT (4D CT) is the basis of radiotherapy treatment planning of thoracic and abdominal tumors. Current clinical 4D CT images suffer, however, from artifacts due to unfulfilled assumptions ...

    Authors: René Werner, Christian Hofmann, Eike Mücke and Tobias Gauer
    Citation: Radiation Oncology 2017 12:100
  41. Managing inter-fractional anatomy changes is a challenging task in radiotherapy of pancreatic tumors, especially in scanned carbon-ion delivery. This treatment planning study aims to focus on clinically feasib...

    Authors: Vania Batista, Daniel Richter, Stephanie E. Combs and Oliver Jäkel
    Citation: Radiation Oncology 2017 12:94
  42. The decrease in peripheral blood lymphocytes induced by radiation lessens the antitumour effect of the immune response, which might cause immunosuppression. We aimed to investigate the correlation between the ...

    Authors: Jing Liu, Qianqian Zhao, Weiye Deng, Jie Lu, Xiaoqing Xu, Renben Wang, Xia Li and Jinbo Yue
    Citation: Radiation Oncology 2017 12:90

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