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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. This study compared adaptive replanning and repositioning corrections based on soft-tissue matching for prostate cancer by using the magnetic resonance-guided radiation therapy (MRgRT) system.

    Authors: Jung-in Kim, Jong Min Park, Chang Heon Choi, Hyun Joon An, Yi-Jun Kim and Jin Ho Kim
    Citation: Radiation Oncology 2019 14:139
  2. To quantify the dosimetric parameters of different bone marrow sparing strategies and to determine the optimal strategy for cervical cancer patients undergoing postoperative intensity-modulated radiotherapy (I...

    Authors: Zhirong Bao, Dajiang Wang, Shupeng Chen, Min Chen, Dazhen Jiang, Chunxu Yang, Hui Liu, Jing Dai and Conghua Xie
    Citation: Radiation Oncology 2019 14:118
  3. Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby
    Citation: Radiation Oncology 2019 14:134
  4. The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita
    Citation: Radiation Oncology 2019 14:133
  5. To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee
    Citation: Radiation Oncology 2019 14:131
  6. To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang
    Citation: Radiation Oncology 2019 14:129
  7. Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study pres...

    Authors: J. Visser, P. de Boer, K. F. Crama, Z. van Kesteren, C. R. N. Rasch, L. J. A. Stalpers and A. Bel
    Citation: Radiation Oncology 2019 14:126
  8. To determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Secondly, to evaluat...

    Authors: Vincent C. Hamming, Christa Visser, Estelle Batin, Leah N. McDermott, Dianne M. Busz, Stefan Both, Johannes A. Langendijk and Nanna M. Sijtsema
    Citation: Radiation Oncology 2019 14:125
  9. Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated t...

    Authors: Stewart Mein, Ivana Dokic, Carmen Klein, Thomas Tessonnier, Till Tobias Böhlen, Guiseppe Magro, Julia Bauer, Alfredo Ferrari, Katia Parodi, Thomas Haberer, Jürgen Debus, Amir Abdollahi and Andrea Mairani
    Citation: Radiation Oncology 2019 14:123
  10. To calculate the individualized fraction regime (IFR) in stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) patients using the uncomplicated tumor control probability (UTCP, P+) function...

    Authors: Jia-Yang Lu, Pei-Xian Lin and Bao-Tian Huang
    Citation: Radiation Oncology 2019 14:111
  11. The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues
    Citation: Radiation Oncology 2019 14:108
  12. In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2019 14:103
  13. Liver tumors are subject to motion with respiration, which is typically accounted for by increasing the target volume. The prescription dose is often reduced to keep the mean liver dose under a threshold level...

    Authors: M. Gargett, C. Haddad, A. Kneebone, J. T. Booth and N. Hardcastle
    Citation: Radiation Oncology 2019 14:93
  14. Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity....

    Authors: J. C. L. Alfonso and L. Berk
    Citation: Radiation Oncology 2019 14:88
  15. Intrafraction motion is particularly problematic in case of small target volumes and narrow margins. Here we simulate the dose coverage of intraprostatic lesions (IPL) by simultaneous integrated boosts (SIB). ...

    Authors: Hendrik Ballhausen, Minglun Li, Michael Reiner and Claus Belka
    Citation: Radiation Oncology 2019 14:81

    The Data Descriptor to this article has been published in Scientific Data 2019 6:269

  16. For radiotherapy of abdominal cancer, four-dimensional magnetic resonance imaging (4DMRI) is desirable for tumor definition and the assessment of tumor and organ motion. However, irregular breathing gives rise...

    Authors: Z. van Kesteren, A. van der Horst, O. J. Gurney-Champion, I. Bones, D. Tekelenburg, T. Alderliesten, G. van Tienhoven, R. Klaassen, H. W. M. van Laarhoven and A. Bel
    Citation: Radiation Oncology 2019 14:80
  17. To reduce radiation doses to the tongue, a patient-specific semi-customized tongue displacement device (SCTDD) was developed using a 3D printer (3DP) for head and neck (H&N) radiation therapy (RT). Dosimetric ...

    Authors: Chae-Seon Hong, Dongryul Oh, Sang Gyu Ju, Yong Chan Ahn, Cho Hee Na, Dong Yeol Kwon and Cheol Chong Kim
    Citation: Radiation Oncology 2019 14:79
  18. Commissioning of treatment planning systems (TPS) and beam delivery for scanned light ion beams is an important quality assurance task. This requires measurement of large sets of high quality dosimetric data i...

    Authors: O. Jäkel, B. Ackermann, S. Ecker, M. Ellerbrock, P. Heeg, K. Henkner and M. Winter
    Citation: Radiation Oncology 2019 14:77
  19. The radiation transmission through the multileaf collimators is undesired in modern techniques such as volumetric modulated arc therapy (VMAT). According to identical plans, in this study, we aim to investigat...

    Authors: Kai Xie, Hongfei Sun, Liugang Gao, Tao Lin, Jianfeng Sui and Xinye Ni
    Citation: Radiation Oncology 2019 14:75
  20. In this study, an external 8 mm thick aluminum target was installed on the upper accessory tray mount of a medical linear accelerator head. The purpose of this study was to determine the effects of the externa...

    Authors: Jonggeun Baek, Hyungdong Kim, Byungyong Kim, Youngkee Oh and Hyunsoo Jang
    Citation: Radiation Oncology 2019 14:70
  21. To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator.

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Tomohiro Ono, Hiraku Iramina and Takashi Mizowaki
    Citation: Radiation Oncology 2019 14:62
  22. We evaluated the optimal radiotherapy (RT) plan for synchronous bilateral breast cancer (SBBC), especially treatment plans including the regional lymph node (LN) area.

    Authors: Yeona Cho, Yoon Jin Cho, Won Suk Chang, Jun Won Kim, Won Hoon Choi and Ik Jae Lee
    Citation: Radiation Oncology 2019 14:56
  23. To perform a dosimetric evaluation of four different simultaneous integrated boost whole brain radiotherapy modalities with hippocampus and inner ear avoidance in the treatment of limited brain metastases.

    Authors: Aijun Jiang, Weipeng Sun, Fen Zhao, Zhenxuan Wu, Dongping Shang, Qingxi Yu, Suzhen Wang, Jian Zhu, Fengchang Yang and Shuanghu Yuan
    Citation: Radiation Oncology 2019 14:46
  24. To develop and validate a quantitative complication model of temporal lobe necrosis (TLN). To analyze the effect of clinical and dosimetric factors on TLN.

    Authors: Jiazhou Wang, Yibing Miao, Xiaomin Ou, Xiaoshen Wang, Xiayun He, Chunying Shen, Hongmei Ying, Weigang Hu and Chaosu Hu
    Citation: Radiation Oncology 2019 14:42
  25. Measurement-guided dose reconstruction has lately attracted significant attention because it can predict the delivered patient dose distribution. Although the treatment planning system (TPS) uses sophisticated...

    Authors: Akari Kaneko, Iori Sumida, Hirokazu Mizuno, Fumiaki Isohashi, Osamu Suzuki, Yuji Seo, Keisuke Otani, Keisuke Tamari and Kazuhiko Ogawa
    Citation: Radiation Oncology 2019 14:36
  26. Time-resolved volumetric magnetic resonance imaging (4DMRI) offers the potential to analyze 3D motion with high soft-tissue contrast without additional imaging dose. We use 4DMRI to investigate the interplay e...

    Authors: Kai Dolde, Ye Zhang, Naved Chaudhri, Christian Dávid, Marc Kachelrieß, Antony John Lomax, Patrick Naumann, Nami Saito, Damien Charles Weber and Asja Pfaffenberger
    Citation: Radiation Oncology 2019 14:30
  27. The purpose of this study was to compare automatically generated VMAT plans to find the superior beam configurations for Pinnacle3 Auto-Planning and share “best practices”.

    Authors: Anne Richter, Florian Exner, Klaus Bratengeier, Bülent Polat, Michael Flentje and Stefan Weick
    Citation: Radiation Oncology 2019 14:12
  28. Due to the heterogeneity of patient’s individual respiratory motion pattern in lung stereotactic body radiotherapy (SBRT), treatment planning dose assessment using a traditional four-dimensional computed tomog...

    Authors: Gang Liu, Fala Hu, Xuanfeng Ding, Xiaoqiang Li, Qihong Shao, Yuenan Wang, Jing Yang and Hong Quan
    Citation: Radiation Oncology 2019 14:1
  29. PRIMO is a dose verification system based on the general-purpose Monte Carlo radiation transport code penelope, which implements an accurate physics model of the interaction cross sections and the radiation trans...

    Authors: Miguel Rodriguez, Josep Sempau, Christian Bäumer, Beate Timmermann and Lorenzo Brualla
    Citation: Radiation Oncology 2018 13:256
  30. Dose calculations in intraoperative electron radiation therapy (IOERT) rely on the conventional assumption of water-equivalent tissues at the applicator end, which defines a flat irradiation surface. However, ...

    Authors: Verónica García-Vázquez, Begoña Sesé-Lucio, Felipe A. Calvo, Juan J. Vaquero, Manuel Desco and Javier Pascau
    Citation: Radiation Oncology 2018 13:243
  31. Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers...

    Authors: Marc Ziegler, Tobias Brandt, Sebastian Lettmaier, Rainer Fietkau and Christoph Bert
    Citation: Radiation Oncology 2018 13:242
  32. Advanced clinical applications, such as dose accumulation and adaptive radiation therapy, require deformable image registration (DIR) algorithms capable of voxel-wise accurate mapping of treatment dose or func...

    Authors: An Qin, Dan Ionascu, Jian Liang, Xiao Han, Nicolette O’Connell and Di Yan
    Citation: Radiation Oncology 2018 13:240
  33. To introduce the benefits of tangent-based volumetric modulated arc therapy (TVMAT), an innovative radiotherapy planning technique, compared with traditional volumetric modulated arc therapy (VMAT) for advance...

    Authors: Pei-Chieh Yu, Ching-Jung Wu, Hsin-Hua Nien, Louis Tak Lui, Suzun Shaw and Yu-Lun Tsai
    Citation: Radiation Oncology 2018 13:236
  34. A new strategy is introduced combining the use of Multi-Criteria Optimization-based Trade-Off Exploration (TO) and RapidPlan™ (RP) for the selection of optimisation parameters that improve the trade-off betwee...

    Authors: Eliane Miguel-Chumacero, Garry Currie, Abigail Johnston and Suzanne Currie
    Citation: Radiation Oncology 2018 13:229
  35. Neoadjuvant radio(chemo)therapy of non-metastasized, borderline resectable or unresectable locally advanced pancreatic cancer is complex and prone to cause side-effects, e.g., in gastrointestinal organs. Inten...

    Authors: Sarah Stefanowicz, Kristin Stützer, Sebastian Zschaeck, Annika Jakobi and Esther G. C. Troost
    Citation: Radiation Oncology 2018 13:228
  36. The dosimetric leaf gap (DLG) and multileaf collimator (MLC) transmission are two important systematic parameters used to model the rounded MLC leaf ends effect when commissioning an Eclipse treatment planning...

    Authors: Chih-Yuan Lin, An-Cheng Shiau, Jin-Huei Ji, Chia-Jung Lee, Ti-Hao Wang, Shu-Hui Hsu and Ji-An Liang
    Citation: Radiation Oncology 2018 13:222
  37. Radiotherapy of liver metastases is commonly being performed with photon-beam based stereotactic body radiation therapy (SBRT). The high risk for radiation-induced liver disease (RILD) is a limiting factor in ...

    Authors: Gracinda Mondlane, Ana Ureba, Michael Gubanski, P A Lind and Albert Siegbahn
    Citation: Radiation Oncology 2018 13:206
  38. Computed tomography (CT) data used for patient radiotherapy planning can nowadays be used to create 3D-printed boluses. Nevertheless, this methodology requires a second CT scan and planning process when immobi...

    Authors: Giovanna Dipasquale, Alexis Poirier, Yannick Sprunger, Johannes Wilhelmus Edmond Uiterwijk and Raymond Miralbell
    Citation: Radiation Oncology 2018 13:203
  39. Technological advances in Hodgkin lymphoma (HL) radiation therapy (RT) by high conformal treatments potentially increase control over organs-at-risk (OARs) dose distribution. However, plan optimization remains...

    Authors: Stefania Clemente, Caterina Oliviero, Giuseppe Palma, Vittoria D’Avino, Raffaele Liuzzi, Manuel Conson, Roberto Pacelli and Laura Cella
    Citation: Radiation Oncology 2018 13:202
  40. In adults, a single pre-treatment four-dimensional CT (4D-CT) acquisition is often used to account for respiratory-induced target motion during radiotherapy. However, studies have indicated that a 4D-CT is not...

    Authors: Sophie C. Huijskens, Irma W. E. M. van Dijk, Jorrit Visser, Brian V. Balgobind, Coen R. N. Rasch, Tanja Alderliesten and Arjan Bel
    Citation: Radiation Oncology 2018 13:198
  41. Pancreatic ductal adenocarcinoma has dismal prognosis. Most patients receive radiation therapy (RT), which is complicated by respiration induced organ motion in upper abdomen. The purpose of this study is to r...

    Authors: Wensha Yang, Zhaoyang Fan, Zixin Deng, Jianing Pang, Xiaoming Bi, Benedick A Fraass, Howard Sandler, Debiao Li and Richard Tuli
    Citation: Radiation Oncology 2018 13:191
  42. Modern radiotherapy offers the possibility of highly accurate tumor treatment. To benefit from this precision at its best, regular positioning verification is necessary. By the use of image-guided radiotherapy...

    Authors: Katharina Bell, Norbert Licht, Christian Rübe and Yvonne Dzierma
    Citation: Radiation Oncology 2018 13:190

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