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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Neoadjuvant radiotherapy (RT) has been shown to improve local control; however, whether it can improve overall survival (OS) in locally advanced rectal cancer (LARC) patients remains controversial. We therefor...

    Authors: Feng Zhao, Jili Wang, Hao Yu, Xiaofei Cheng, Xinke Li, Xuan Zhu, Xiangming Xu, Jianjiang Lin, Xin Chen and Senxiang Yan
    Citation: Radiation Oncology 2020 15:49
    Content type: Research Published on:

  2. To analyze patterns of failure in patients with LA-NSCLC who received definitive chemoradiotherapy (CRT) and to build a nomogram for predicting the failure patterns in this population of patients.

    Authors: Xueru Zhu, Runping Hou, Xiaoyang Li, Chang Jiang, Wuyan Xia and Xiaolong Fu
    Citation: Radiation Oncology 2020 15:43
    Content type: Research Published on:

  3. On the elastic profiles of human teeth after radiotherapy for head and neck cancers, generation of dental complications, which may bring several side effects preventing the quality of life, has not well clarif...

    Authors: Irem Demirkan, Gokhan Yaprak, Cemile Ceylan, Emriye Algul, Ceyda Ozcakir Tomruk, Bukem Bilen and Mehmet Burcin Unlu
    Citation: Radiation Oncology 2020 15:38
    Content type: Research Published on:

  4. There is limited data on the use of targeted or immunotherapy (TT/IT) in combination with single fraction stereotactic radiosurgery (SRS) in patients with melanoma brain metastasis (MBM). Therefore, we analyze...

    Authors: Indrawati Hadi, Olarn Roengvoraphoj, Raphael Bodensohn, Jan Hofmaier, Maximilian Niyazi, Claus Belka and Silke Birgit Nachbichler
    Citation: Radiation Oncology 2020 15:37
    Content type: Research Published on:

  7. The development of radiation pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT) is known to be associated with many different factors, although historical analyses of RP have commonly utilized hetero...

    Authors: Jeffrey M. Ryckman, Michael Baine, Joseph Carmicheal, Ferdinand Osayande, Richard Sleightholm, Kaeli Samson, Dandan Zheng, Weining Zhen, Chi Lin and Chi Zhang
    Citation: Radiation Oncology 2020 15:33
    Content type: Research Published on:

    The Correction to this article has been published in Radiation Oncology 2021 16:67

  8. In this study we have evaluated the accuracy of automatic, deformable structure propagation from planning CT and MR scans for daily online plan adaptation for MR linac (MRL) treatment, which is an important el...

    Authors: Rasmus Lübeck Christiansen, Lars Dysager, Anders Smedegaard Bertelsen, Olfred Hansen, Carsten Brink and Uffe Bernchou
    Citation: Radiation Oncology 2020 15:32
    Content type: Research Published on:

  9. Head-and-neck squamous cell carcinoma (HNSCC) is one of the most common malignancies globally, and the number of elderly patients diagnosed with HNSCC is increasing. However, as elderly HNSCC patients are unde...

    Authors: Erik Haehl, Alexander Rühle, Hélène David, Tobias Kalckreuth, Tanja Sprave, Raluca Stoian, Christoph Becker, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay
    Citation: Radiation Oncology 2020 15:31
    Content type: Research Published on:

  10. Local ablative treatment strategies are frequently offered to patients diagnosed with oligometastatic disease. Stereotactic body radiotherapy (SBRT), as ablative treatment option, is well established for lung ...

    Authors: Laila König, Matthias F. Häfner, Sonja Katayama, Stefan A. Koerber, Eric Tonndorf-Martini, Denise Bernhardt, Bastian von Nettelbladt, Fabian Weykamp, Philipp Hoegen, Sebastian Klüter, Matthew S. Susko, Jürgen Debus and Juliane Hörner-Rieber
    Citation: Radiation Oncology 2020 15:30
    Content type: Research Published on:

  11. Colorectal cancer treatment requires a complex, multidisciplinary approach. Because of the potential variability, monitoring through clinical audits is advisable. This study assesses the effects of a quality i...

    Authors: M. G. Torras, E. Canals, C. Muñoz-Montplet, A. Vidal, D. Jurado, A. Eraso, S. Villà, M. Caro, J. Molero, M. Macià, M. Puigdemont, E. González-Muñoz, A. López, F. Guedea and J. M. Borras
    Citation: Radiation Oncology 2020 15:28
    Content type: Research Published on:

  12. Small inter- and intrafractional prostate motion was shown to be a prerequisite for precise radiotherapy (RT) of prostate cancer (PCa) to achieve good local control and low rectal toxicity. As rectal gas and r...

    Authors: Christian Schaefer, Constantinos Zamboglou, Natalja Volegova-Neher, Carmen Martini, Nils Henrik Nicolay, Nina-Sophie Schmidt-Hegemann, Paul Rogowski, Minglun Li, Claus Belka, Arndt-Christian Müller, Anca-Ligia Grosu and Thomas Brunner
    Citation: Radiation Oncology 2020 15:27
    Content type: Research Published on:

  13. Single session radiosurgery represents a widely accepted treatment for intracranial meningiomas. However, this approach could involve a high risk of treatment-related complications when applied to large volume...

    Authors: V. Pinzi, M. Marchetti, E. De Martin, V. Cuccarini, I. Tramacere, F. Ghielmetti, M. L. Fumagalli, C. Iezzoni and L. Fariselli
    Citation: Radiation Oncology 2020 15:26
    Content type: Study protocol Published on:

  14. To evaluate the long-term efficacy and toxicity of radiation therapy in patients with Stage IE primary ocular adnexal mucosa-associated lymphoid tissue lymphoma.

    Authors: Masanari Niwa, Satoshi Ishikura, Kotoha Tatekawa, Natsuko Takama, Akifumi Miyakawa, Toshinobu Kubota, Eriko Kato and Yuta Shibamoto
    Citation: Radiation Oncology 2020 15:25
    Content type: Research Published on:

  15. Stereotactic Ablative Radiotherapy (SABR) is an effective treatment that improves local control for many tumours. However, the role of SABR in gynecological cancers (GYN) has not been well-established. We hypo...

    Authors: E. Leung, A. Gladwish, A. Sahgal, S. S. Lo, C. A. Kunos, R. M. Lanciano, C. A. Mantz, M. Guckenberger, T. M. Zagar, N. A. Mayr, A. R. Chang, S. Jorcano, T. Biswas, A. Pontoriero and K. V. Albuquerque
    Citation: Radiation Oncology 2020 15:24
    Content type: Research Published on:

  16. Curative intent therapy of stage II NSCLC may include surgical resection or definitive radiotherapy. Primary management with surgery or radiotherapy may be influenced by patient and disease characteristics. We...

    Authors: Sara Moore, Bonnie Leung, Jonn Wu and Cheryl Ho
    Citation: Radiation Oncology 2020 15:23
    Content type: Research Published on:

  17. There is a lack of data on the biologically effective dose and the efficacy of stereotactic body radiotherapy in hepatocellular carcinoma patients, and this study was conducted to explore the relation between ...

    Authors: Jing Sun, Aimin Zhang, Wengang Li, Quan Wang, Dong Li, Dan Zhang and Xuezhang Duan
    Citation: Radiation Oncology 2020 15:20
    Content type: Study protocol Published on:

  18. Distant Metastases from Head and Neck Squamous cell carcinomas are uncommon (9–11%) and they are usually found in the lung and less frequently in the liver, kidney and adrenals.

    Authors: Agostino Cristaudo, Antonio Stefanelli, Stefano Ursino, Durim Delishaj, Davide Baldaccini, Alessandra Gonnelli and Fabiola Paiar
    Citation: Radiation Oncology 2020 15:18
    Content type: Case report Published on:

  19. To compare the efficacy and toxicity of hypofractionated radiotherapy versus conventional fractionated radiotherapy in postmastectomy breast cancer using meta-analysis.

    Authors: Lei Liu, Yongqiang Yang, Qi Guo, Bixin Ren, Qiliang Peng, Li Zou, Yaqun Zhu and Ye Tian
    Citation: Radiation Oncology 2020 15:17
    Content type: Review Published on:

  20. The benefit of adjuvant radiotherapy (ART) for extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma (GBC) is unclear, with conflicting results from nonrandomized studies. We reported a meta-analysi...

    Authors: Bixin Ren, Qi Guo, Yongqiang Yang, Lei Liu, Shaohua Wei, Wei Chen and Ye Tian
    Citation: Radiation Oncology 2020 15:15
    Content type: Review Published on:

  21. Limited stage small cell lung cancer (LS-SCLC) has a poor prognosis. Additional prognostic markers are needed for risk-stratification and treatment intensification. This study compares quantitative CT-based vo...

    Authors: Sophia C. Kamran, Thibaud Coroller, Nastaran Milani, Vishesh Agrawal, Elizabeth H. Baldini, Aileen B. Chen, Bruce E. Johnson, David Kozono, Idalid Franco, Nitish Chopra, Roman Zeleznik, Hugo J. W. L. Aerts and Raymond Mak
    Citation: Radiation Oncology 2020 15:14
    Content type: Research Published on:

  22. Neoadjuvant external-beam radiotherapy (EBRT) with concomitant chemotherapy is the current standard-of-care for locally-advanced rectal cancer. Intraoperative radiotherapy (IORT) is to date only recommended fo...

    Authors: Sergey Potemin, Jens Kübler, Ivan Uvarov, Frederik Wenz and Frank Giordano
    Citation: Radiation Oncology 2020 15:11
    Content type: Research Published on:

  24. Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, prolifera...

    Authors: Yang Tang, Li Yang, Wan Qin, Min’ Xiao Yi, Bo Liu and Xiang’Lin Yuan
    Citation: Radiation Oncology 2020 15:9
    Content type: Research Published on:

  25. Definitive chemoradiotherapy (dCRT) is a standard treatment for patients with locally advanced head and neck cancer. There is a clinical need for a stratification of this prognostically heterogeneous group of ...

    Authors: Lars Schüttrumpf, Sebastian Marschner, Katrin Scheu, Julia Hess, Sibylle Rietzler, Axel Walch, Philipp Baumeister, Thomas Kirchner, Ute Ganswindt, Horst Zitzelsberger, Claus Belka and Cornelius Maihoefer
    Citation: Radiation Oncology 2020 15:7
    Content type: Research Published on:

  26. mmune checkpoint inhibition (CPI) has an increasing impact in the multimodal treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Increasing evidence suggests treatment outcome depending on tum...

    Authors: Kathrin Gennen, Lukas Käsmann, Julian Taugner, Chukwuka Eze, Monika Karin, Olarn Roengvoraphoj, Jens Neumann, Amanda Tufman, Michael Orth, Simone Reu, Claus Belka and Farkhad Manapov
    Citation: Radiation Oncology 2020 15:5
    Content type: Research Published on:

  27. The development of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) has dramatically improved the prognosis of patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The purpose o...

    Authors: Lihao Zhao, Xiaona Cai, Didi Chen, Xuxue Ye, Mengdan Gao, Lihuai Lu, Huafang Su, Meng Su, Meng Hou and Congying Xie
    Citation: Radiation Oncology 2019 15:3
    Content type: Research Published on:

  28. Iodine seed implant brachytherapy is indicated for low risk and selected favorable intermediate risk prostate cancers. A percentage of positive biopsies > 50% is usually considered as a contra-indication, and ...

    Authors: Claire Meynard, Andres Huertas, Charles Dariane, Sandra Toublanc, Quentin Dubourg, Saik Urien, Marc-Olivier Timsit, Arnaud Méjean, Nicolas Thiounn and Philippe Giraud
    Citation: Radiation Oncology 2019 15:1
    Content type: Research Published on:

  29. Volumetric Modulated Arc Therapy (VMAT) techniques have recently been implemented in clinical practice for total-body irradiation (TBI). To date, most techniques still use special couches, translational tables...

    Authors: Christoph Losert, Roel Shpani, Robert Kießling, Philipp Freislederer, Minglun Li, Franziska Walter, Maximilian Niyazi, Michael Reiner, Claus Belka and Stefanie Corradini
    Citation: Radiation Oncology 2019 14:244
    Content type: Research Published on:

  30. Existing pencil beam analytical (PBA) algorithms for proton therapy treatment planning are not ideal for sites with heterogeneous tissue density and do not account for the spatial variations in proton relative...

    Authors: Yolanda D. Tseng, Shadonna M. Maes, Gregory Kicska, Patricia Sponsellor, Erik Traneus, Tony Wong, Robert D. Stewart and Jatinder Saini
    Citation: Radiation Oncology 2019 14:243
    Content type: Research Published on:

  31. The effectiveness of proton beam therapy (PBT) as initial treatment for patients with unresectable intrahepatic cholangiocarcinoma (ICC) is unclear, particularly as related to ICC histological subtypes. We per...

    Authors: Shosei Shimizu, Toshiyuki Okumura, Yoshiko Oshiro, Nobuyoshi Fukumitsu, Kuniaki Fukuda, Kazunori Ishige, Naoyuki Hasegawa, Haruko Numajiri, Keiko Murofushi, Kayoko Ohnishi, Masashi Mizumoto, Tetsuo Nonaka, Hitoshi Ishikawa and Hideyuki Sakurai
    Citation: Radiation Oncology 2019 14:241
    Content type: Research Published on:

  32. As optic nerve sheath meningiomas (ONSM) are rare, there are no prospective studies. Our retrospective analysis focusses on a cohort of patients with uniform disease characteristics all treated with the same r...

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen
    Citation: Radiation Oncology 2019 14:240
    Content type: Research Published on:

    The Correction to this article has been published in Radiation Oncology 2020 15:268

  33. conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

    Authors: Juliette Thariat, Julia Salleron, Celia Maschi, Edouard Fevrier, Sandra Lassalle, Lauris Gastaud, Stephanie Baillif, Audrey Claren, Florent Baumard, Joel Herault and Jean Pierre Caujolle
    Citation: Radiation Oncology 2019 14:239
    Content type: Research Published on:

  34. Some studies have demonstrated that concurrent chemo-radiotherapy is an effective salvage treatment for isolated para-aortic lymph node (PALN) recurrence.

    Authors: Hikaru Kubota, Kayoko Tsujino, Nor Shazrina Sulaiman, Shuhei Sekii, Yoko Matsumoto, Yosuke Ota, Toshinori Soejima, Satoshi Yamaguchi and Ryohei Sasaki
    Citation: Radiation Oncology 2019 14:236
    Content type: Research Published on:

  35. To update the clinical outcome of an elderly women cohort with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interst...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi
    Citation: Radiation Oncology 2019 14:234
    Content type: Short report Published on:

  36. The present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head m...

    Authors: Julian Mangesius, Thomas Seppi, Rocco Weigel, Christoph Reinhold Arnold, Danijela Vasiljevic, Georg Goebel, Peter Lukas, Ute Ganswindt and Meinhard Nevinny-Stickel
    Citation: Radiation Oncology 2019 14:231
    Content type: Research Published on:

  37. How to protect the ovarian function during radiotherapy is uncertain. The purpose of this study was to explore the association between the location of the transposed ovary and the ovarian dose in patients with...

    Authors: Xiao-juan Lv, Xiao-long Cheng, Ye-qiang Tu, Ding-ding Yan and Qiu Tang
    Citation: Radiation Oncology 2019 14:230
    Content type: Research Published on:

  39. The new staging system of cervical cancer issued in 2018 by the International Federation of Gynecology and Obstetrics (FIGO), calls for a new evaluation of the efficacy of prophylactic extended field irradiati...

    Authors: Qingyu Meng, Xiaoliang Liu, Weiping Wang, Xiaorong Hou, Xin Lian, Shuai Sun, Junfang Yan, Zhikai Liu, Zheng Miao, Ke Hu and Fuquan Zhang
    Citation: Radiation Oncology 2019 14:228
    Content type: Research Published on:

  40. Current standard of treatment for newly diagnosed patients with glioblastoma (GBM) is surgical resection with adjuvant normofractionated radiotherapy (NFRT) combined with temozolomide (TMZ) chemotherapy. Hyper...

    Authors: Victor Lewitzki, Rainer J. Klement, Rebekka Kosmala, Dominik Lisowski, Michael Flentje and Bülent Polat
    Citation: Radiation Oncology 2019 14:227
    Content type: Research Published on:

  41. To determine the best method to contour the planning organ at risk volume (PRV) for the urethra, this study aimed to investigate the displacement of a Foley catheter in the urethra with a soft and thin guide-w...

    Authors: Yasuhiro Dekura, Kentaro Nishioka, Takayuki Hashimoto, Naoki Miyamoto, Ryusuke Suzuki, Takaaki Yoshimura, Ryuji Matsumoto, Takahiro Osawa, Takashige Abe, Yoichi M. Ito, Nobuo Shinohara, Hiroki Shirato and Shinichi Shimizu
    Citation: Radiation Oncology 2019 14:226
    Content type: Research Published on:

  42. The purpose of this study was to determine the associations between pathological complete remission (pCR) and clinical outcomes in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) w...

    Authors: Kai Wang, Junlin Yi, Xiaodong Huang, Yuan Qu, Jingwei Luo, Jianping Xiao, Shiping Zhang, Yuan Tang, Weixin Liu, Guozhen Xu, Li Gao, Zhengang Xu, Shaoyan Liu and Xiaolei Wang
    Citation: Radiation Oncology 2019 14:225
    Content type: Research Published on:

  43. The addition of regional nodal radiation (RNI) to whole breast irradiation for high risk breast cancer improves metastases free survival and new data suggests it contributes additional benefit to overall survi...

    Authors: Chloe Pandeli, Lloyd M. L. Smyth, Steven David and Andrew W. See
    Citation: Radiation Oncology 2019 14:223
    Content type: Research Published on:

  44. Mast Cell Activation Syndrome (MCAS) is classified as an idiopathic mast cell disorder where inconsistent or unknown triggers release inflammatory mediators and cause a constellation of symptoms. Studies demon...

    Authors: Robin E. Landy, William C. Stross, Jackson M. May, Tasneem A. Kaleem, Timothy D. Malouff, Mark R. Waddle and Laura A. Vallow
    Citation: Radiation Oncology 2019 14:222
    Content type: Case report Published on:

  45. The aim of this study was to explore the relationships between dosimetric parameters of organs at risk and patient-reported outcomes (PRO) after radiotherapy of patients with head and neck cancer.

    Authors: Toyokazu Hayakawa, Shogo Kawakami, Itaru Soda, Takuro Kainuma, Marika Nozawa, Akane Sekiguchi, Shunsuke Miyamoto, Taku Yamashita and Hiromichi Ishiyama
    Citation: Radiation Oncology 2019 14:221
    Content type: Research Published on:

  46. A novel unconventional SBRT-based PArtial Tumor irradiation targeting HYpoxic clonogenic cells (SBRT-PATHY) for induction of the tumoricidal bystander (BE) and abscopal effects (AE) was developed by translatin...

    Authors: Slavisa Tubin, Martin Ashdown and Branislav Jeremic
    Citation: Radiation Oncology 2019 14:220
    Content type: Short report Published on:

  47. The microscopic tumor spread (MS) beyond the macroscopic tumor borders of esophageal tumors is crucial for determining the clinical target volume (CTV) in radiotherapy. The question arises whether current volu...

    Authors: Melanie Machiels, Maurits L. van Montfoort, Nikki B. Thuijs, Mark I. van Berge Henegouwen, Tanja Alderliesten, Sybren L. Meijer, Jeanin E. van Hooft and Maarten C. C. M. Hulshof
    Citation: Radiation Oncology 2019 14:219
    Content type: Research Published on:

  48. This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer.

    Authors: Jingwen Wang, Yun Guan, Weilie Gu, Senxiang Yan, Juying Zhou, Dan Huang, Tong Tong, Chao Li, Sanjun Cai, Zhen Zhang and Ji Zhu
    Citation: Radiation Oncology 2019 14:215
    Content type: Research Published on:

  49. Accurate and standardized descriptions of organs at risk (OARs) are essential in radiation therapy for treatment planning and evaluation. Traditionally, physicians have contoured patient images manually, which...

    Authors: Sang Hee Ahn, Adam Unjin Yeo, Kwang Hyeon Kim, Chankyu Kim, Youngmoon Goh, Shinhaeng Cho, Se Byeong Lee, Young Kyung Lim, Haksoo Kim, Dongho Shin, Taeyoon Kim, Tae Hyun Kim, Sang Hee Youn, Eun Sang Oh and Jong Hwi Jeong
    Citation: Radiation Oncology 2019 14:213
    Content type: Research Published on:

  50. Radiotherapy-induced lymphopenia may be limiting the success of therapy and could also negatively affect the ability of immune system in mediating the bystander (BE) and abscopal effects (AE). A novel SBRT-bas...

    Authors: Slavisa Tubin, Mohammad K. Khan, Gerardo Salerno, Waleed F. Mourad, Weisi Yan and Branislav Jeremic
    Citation: Radiation Oncology 2019 14:212
    Content type: Methodology Published on:
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Radiation Oncology

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