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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Stereotactic radiosurgery (SRS) is an effective treatment for trigeminal neuralgia (TN). Nevertheless, a proportion of patients will experience recurrence and treatment-related sensory disturbances. In order t...

    Authors: Alfredo Conti, Gueliz Acker, Antonio Pontoriero, Juliane Hardt, Anne Kluge, Alberto Cacciola, Giuseppe Iatì, Markus Kufeld, Volker Budach, Peter Vajkoczy, Giancarlo Beltramo, Stefano Pergolizzi, Achille Bergantin, Franziska Loebel, Silvana Parisi, Carolin Senger…
    Citation: Radiation Oncology 2020 15:115
    Content type: Research Published on:

  2. We evaluated whether pre- and mid-treatment metabolic tumor volume (MTV) predicts per lesion local recurrence (LR) in patients treated with definitive radiation therapy (RT, dose≥60 Gy) for locally advanced no...

    Authors: Michael S. Binkley, Julie L. Koenig, Mehr Kashyap, Michael Xiang, Yufei Liu, Quaovi Sodji, Peter G. Maxim, Maximilian Diehn, Billy W. Loo Jr and Michael F. Gensheimer
    Citation: Radiation Oncology 2020 15:114
    Content type: Research Published on:

  3. The number of nonagenarian cancer patients (≥ 90 years) is continuously increasing, and radiotherapy is performed in a relevant proportion of patients, as surgery and chemotherapy are often not feasible for th...

    Authors: Tanja Sprave, Alexander Rühle, Raluca Stoian, Alina Weber, Constantinos Zamboglou, Carsten Nieder, Anca-Ligia Grosu and Nils H. Nicolay
    Citation: Radiation Oncology 2020 15:113
    Content type: Research Published on:

  5. To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.

    Authors: Hans Geinitz, Carsten Nieder, Lukas Kocik, Christine Track, Johann Feichtinger, Theresa Weingartner, Kurt Spiegl, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Dietmar H. Seewald, Reinhold Függer, Andreas Shamiyeh, Andreas L. Petzer, David Kiesl and Josef Hammer
    Citation: Radiation Oncology 2020 15:111
    Content type: Research Published on:

  6. Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-en...

    Authors: Gustavo R. Sarria, Vera Petrova, Frederik Wenz, Yasser Abo-Madyan, Elena Sperk and Frank A. Giordano
    Citation: Radiation Oncology 2020 15:110
    Content type: Research Published on:

  8. Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with ...

    Authors: Dan Wang, Chongshun Liu, Yuan Zhou, Tingyu Yan, Chenglong Li, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Cenap Güngör and Yuqiang Li
    Citation: Radiation Oncology 2020 15:107
    Content type: Research Published on:

  10. Structure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promis...

    Authors: Mark H. F. Savenije, Matteo Maspero, Gonda G. Sikkes, Jochem R. N. van der Voort van Zyp, Alexis N. T. J. Kotte, Gijsbert H. Bol and Cornelis A. T. van den Berg
    Citation: Radiation Oncology 2020 15:104
    Content type: Research Published on:

  11. Radiotherapy treatment of head and neck cancer affects local arteries and increases the risk of stroke. This study aimed at a closer characterization of this damage and its development in time with a longitudi...

    Authors: Cristoforo Simonetto, Michael Mayinger, Thamer Ahmed, Kai Borm, Pavel Kundrát, Steffi Pigorsch, Jan Christian Kaiser and Stephanie E. Combs
    Citation: Radiation Oncology 2020 15:102
    Content type: Research Published on:

  13. Although controversial, there are data suggesting that clinical parameters can predict the probability of sphincter preserving procedures in rectal cancer. The purpose of this study was to investigate the asso...

    Authors: Richard Partl, Marton Magyar, Eva Hassler, Tanja Langsenlehner and Karin Sigrid Kapp
    Citation: Radiation Oncology 2020 15:99
    Content type: Research Published on:

  15. Over the past years, several treatment regimens have been recommended for elderly patients with glioblastoma (GBM), ranging from ultrahypofractionated radiotherapy (RT) over monochemotherapy (ChT) to combined ...

    Authors: Christoph Straube, Kerstin A. Kessel, Stefanie Antoni, Jens Gempt, Bernhard Meyer, Juergen Schlegel, Friederike Schmidt-Graf and Stephanie E. Combs
    Citation: Radiation Oncology 2020 15:97
    Content type: Research Published on:

  16. Skull base chordomas are rare and heterogeneously behaving tumors. Though still classified as benign they can grow rapidly, are locally aggressive, and have the potential to metastasize. To adapt the treatment...

    Authors: Anna-Lena Hottinger, Beat Bojaxhiu, Frank Ahlhelm, Marc Walser, Barbara Bachtiary, Stefan Zepter, Tony Lomax, Alessia Pica and Damien C. Weber
    Citation: Radiation Oncology 2020 15:96
    Content type: Research Published on:

  17. To explore the efficacy and safety of Transcatheter rectal arterial chemoembolization with oxaliplatin and S-1 concurrent chemoradiotherapy as neoadjuvant therapy for locally advanced rectal cancer.

    Authors: Bo Yang, Jinlu Shan, Yan Feng, Nan Dai, Mengxia Li, Chuan Chen, Shengyong He, Ge Wang, Hualiang Xiao, Chunxue Li and Dong Wang
    Citation: Radiation Oncology 2020 15:94
    Content type: Research Published on:

  18. During these last years, new agents have dramatically improved the survival of the metastatic patients. Oligometastases represent a continuous field of interest in which the integration of metastases-directed ...

    Authors: Rosario Mazzola, Barbara Alicja Jereczek-Fossa, Davide Franceschini, Slavisa Tubin, Andrea Riccardo Filippi, Maria Tolia, Andrea Lancia, Giuseppe Minniti, Stefanie Corradini, Stefano Arcangeli, Marta Scorsetti and Filippo Alongi
    Citation: Radiation Oncology 2020 15:92
    Content type: Review Published on:

  19. Esophagitis influences quality of life and might cause treatment interruption and hospitalization. Previous studies of risk factors focused on curative treatment for non-small cell lung cancer (NSCLC), which o...

    Authors: Carsten Nieder, Kristian S. Imingen, Bård Mannsåker, Rosalba Yobuta and Ellinor Haukland
    Citation: Radiation Oncology 2020 15:91
    Content type: Research Published on:

  21. Prognostication tools for early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) are currently lacking. The purpose of this study was to develop and external...

    Authors: Sarah Baker, Katerina Bakunina, Marloes Duijm, Mischa S. Hoogeman, Robin Cornelissen, Imogeen Antonisse, John Praag, Wilma D. Heemsbergen and Joost Jan Nuyttens
    Citation: Radiation Oncology 2020 15:89
    Content type: Research Published on:

  22. Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are wi...

    Authors: M. Unterrainer, C. Eze, H. Ilhan, S. Marschner, O. Roengvoraphoj, N. S. Schmidt-Hegemann, F. Walter, W. G. Kunz, P. Munck af Rosenschöld, R. Jeraj, N. L. Albert, A. L. Grosu, M. Niyazi, P. Bartenstein and C. Belka
    Citation: Radiation Oncology 2020 15:88
    Content type: Review Published on:

  23. Deep learning-based algorithms have demonstrated enormous performance in segmentation of medical images. We collected a dataset of multiparametric MRI and contour data acquired for use in radiosurgery, to eval...

    Authors: Khaled Bousabarah, Maximilian Ruge, Julia-Sarita Brand, Mauritius Hoevels, Daniel Rueß, Jan Borggrefe, Nils Große Hokamp, Veerle Visser-Vandewalle, David Maintz, Harald Treuer and Martin Kocher
    Citation: Radiation Oncology 2020 15:87
    Content type: Research Published on:

  24. Current chemoradiation regimens for locally advanced cervical cancer are fairly uniform despite a profound diversity of treatment response and recurrence patterns. The wide range of treatment responses and pro...

    Authors: Shin-Hyung Park, Myong Hun Hahm, Bong Kyung Bae, Gun Oh Chong, Shin Young Jeong, Sungdae Na, Sungmoon Jeong and Jae-Chul Kim
    Citation: Radiation Oncology 2020 15:86
    Content type: Research Published on:

  25. To evaluate the longitudinal changes of quality of life (QoL) and survival in patients with nasopharyngeal carcinoma (NPC) treated by volumetric-modulated arc therapy (VMAT) versus intensity-modulated radiothe...

    Authors: Tai-Lin Huang, Ming-Hsien Tsai, Hui-Ching Chuang, Chih-Yen Chien, Yu-Tsai Lin, Wen-Ling Tsai and Fu-Min Fang
    Citation: Radiation Oncology 2020 15:84
    Content type: Research Published on:

  26. Glioblastoma is a rapidly proliferating tumor. Patients bear an inferior prognosis with a median survival time of 14-16 months. Proliferation and repopulation are a major resistance promoting factor for conven...

    Authors: N. Guberina, C. Pöttgen, S. Kebir, L. Lazaridis, C. Scharmberg, W. Lübcke, M. Niessen, M. Guberina, B. Scheffler, V. Jendrossek, R. Jabbarli, D. Pierscianek, U. Sure, T. Schmidt, C. Oster, P. Hau…
    Citation: Radiation Oncology 2020 15:83
    Content type: Research Published on:

  27. Hypofractionated stereotactic radiotherapy (HFSRT) is indicated for large brain metastases (BM) or proximity to critical organs (brainstem, chiasm, optic nerves, hippocampus). The primary aim of this study was...

    Authors: Laurence Mengue, Aurélie Bertaut, Louise Ngo Mbus, Mélanie Doré, Myriam Ayadi, Karen Clément-Colmou, Line Claude, Christian Carrie, Cécile Laude, Ronan Tanguy, Julie Blanc and Marie-Pierre Sunyach
    Citation: Radiation Oncology 2020 15:82
    Content type: Research Published on:

  28. Treatment for local and locoregional recurrence or second head-and-neck (H&N) cancers after previous radiotherapy is challenging, and re-irradiation carries a significantly increased risk for radiotherapy-rela...

    Authors: Alexander Rühle, Tanja Sprave, Tobias Kalckreuth, Raluca Stoian, Erik Haehl, Constantinos Zamboglou, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay
    Citation: Radiation Oncology 2020 15:81
    Content type: Research Published on:

  29. To analyze management and outcomes following (chemo)radiation therapy in patients with cervical lymph node metastases from an unknown primary site (CCUP) in a large single-center cohort.

    Authors: Tanja Sprave, Alexander Rühle, Katharina Hees, Tobias Kalckreuth, Vivek Verma, Raluca Stoian, Constantinos Zamboglou, Jens Pfeiffer, Roland Laszig, Andreas Knopf, Anca-Ligia Grosu and Nils H. Nicolay
    Citation: Radiation Oncology 2020 15:80
    Content type: Research Published on:

  30. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) may provide biomarkers of the outcome of locally-advanced cervical carcinoma (LACC). There is, however, no agreement on how DCE-MR recordings shou...

    Authors: Kjersti V. Lund, Trude G. Simonsen, Gunnar B. Kristensen and Einar K. Rofstad
    Citation: Radiation Oncology 2020 15:79
    Content type: Research Published on:

  31. Several studies investigating the role of intraoperative radiotherapy (IORT) in the treatment of resectable pancreatic cancer (PC) have been published; however, their results remain inconsistent. By conducting...

    Authors: Liang Jin, Ning Shi, Shiye Ruan, Baohua Hou, Yiping Zou, Xiongfeng Zou, Haosheng Jin and Zhixiang Jian
    Citation: Radiation Oncology 2020 15:76
    Content type: Review Published on:

  32. The improvement of survival outcomes and the reduction of toxicities for esophageal squamous cell carcinoma (SCC) are still needed. We conducted a pilot study of concurrent chemoradiotherapy with weekly doceta...

    Authors: Qi Liu, Yi Xia, Yun Chen, Junhua Zhang, Jiaying Deng and Kuaile Zhao
    Citation: Radiation Oncology 2020 15:75
    Content type: Research Published on:

  33. The COVID-19 pandemic is challenging modern radiation oncology. At University Hospitals, we have a mandate to offer high-end treatments to all cancer patients. However, in times of crisis we must learn to prio...

    Authors: Stephanie E. Combs, Claus Belka, Maximilian Niyazi, Stefanie Corradini, Steffi Pigorsch, Jan Wilkens, Anca L. Grosu, Matthias Guckenberger, Ute Ganswindt and Denise Bernhardt
    Citation: Radiation Oncology 2020 15:74
    Content type: Review Published on:

  34. To compare CTVHR and OAR dimensions and inter-rater agreement between magnetic resonance (MR) and trans-rectal ultrasound (TRUS) images in IB cervical cancer patients.

    Authors: Lucas C. Mendez, Ananth Ravi, Kevin Martell, Hamid Raziee, Yasir Alayed, Matt Wronski, Moti Paudel, Elizabeth Barnes, Amandeep Taggar, C. S. Wong and Eric Leung
    Citation: Radiation Oncology 2020 15:73
    Content type: Research Published on:

  35. The optimal adjuvant treatment for stage III endometrial cancer in the era of modern radiotherapy remains undefined. We investigated the benefit of adjuvant radiotherapy for women who underwent optimal resecti...

    Authors: Jenny Ling-Yu Chen, Yu-Sen Huang, Chao-Yuan Huang, Che-Yu Hsu, Keng-Hsueh Lan, Wen-Fang Cheng and Sung-Hsin Kuo
    Citation: Radiation Oncology 2020 15:72
    Content type: Research Published on:

  36. Radiation therapy is an integral part of the multidisciplinary management of breast cancer. Regional lymph node irradiation in younger trials seems to provide superior target coverage as well as a reduction in...

    Authors: Jan Haussmann, Stefanie Corradini, Carolin Nestle-Kraemling, Edwin Bölke, Freddy Joel Djiepmo Njanang, Bálint Tamaskovics, Klaus Orth, Eugen Ruckhaeberle, Tanja Fehm, Svjetlana Mohrmann, Ioannis Simiantonakis, Wilfried Budach and Christiane Matuschek
    Citation: Radiation Oncology 2020 15:71
    Content type: Review Published on:

  37. The treatment for brain metastases in small cell lung cancer (SCLC) is still controversial. The purpose of this study was to compare different brain radiotherapy treatments on SCLC patients with brain metastases.

    Authors: Meng Ni, Aijun Jiang, Wenju Liu, Yanxing Sheng, Haiyan Zeng, Ning Liu, Qingxiao Gao, Yong Wang, Jinming Yu and Shuanghu Yuan
    Citation: Radiation Oncology 2020 15:70
    Content type: Research Published on:

  38. Unity Elekta is a unique magnetic resonance (MR)-linac that conjugates a 1.5 Tesla MR unit with a 7 MV flattening filter free accelerator.A prospective observational study for the clinical use of Elekta Unity ...

    Authors: Filippo Alongi, Michele Rigo, Vanessa Figlia, Francesco Cuccia, Niccolò Giaj-Levra, Luca Nicosia, Francesco Ricchetti, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Rosario Mazzola
    Citation: Radiation Oncology 2020 15:69
    Content type: Research Published on:

  39. We investigated the risk factors of radiation-induced thyroid dysfunction, then combined the clinical factors and optimum thyroid dosimetric parameters to predict the incidence rate of hypothyroidism (HT) and ...

    Authors: Ling Zhou, Jia Chen, Wei Shen, Zheng-Lu Chen, Shuang Huang, Chang-Juan Tao, Ming Chen, Zhong-Hua Yu and Yuan-Yuan Chen
    Citation: Radiation Oncology 2020 15:68
    Content type: Research Published on:

  40. This study directs to evaluate the efficacy and safety of intensity-modulated radiotherapy (IMRT) alone versus IMRT plus chemotherapy in intermediate-risk NPC (stage II and T3N0M0).

    Authors: Omer Aftab, Shufang Liao, Rongjun Zhang, Nan Tang, Meiqing Luo, Bin Zhang, Sanjeev Shahi, Raju Rai, Jazib Ali and Wei Jiang
    Citation: Radiation Oncology 2020 15:66
    Content type: Research Published on:

  41. We evaluated the relationship between patient-, tumor-, and treatment-related features and radiation-induced lymphopenia (RIL) and evaluated the correlation between RIL and survival outcome in NPC patients to ...

    Authors: Xiaoxue Xie, Shenglan Gong, Hekun Jin, Pei Yang, Ting Xu, Yilong Cai, Chengxian Guo, Rong Zhang, Fan Lou, Wenjuan Yang and Hui Wang
    Citation: Radiation Oncology 2020 15:65
    Content type: Research Published on:

  42. To assess the safety and efficacy of CyberKnife® radiotherapy (CKRT) for the treatment of olfactory groove meningiomas (OGMs).

    Authors: Jianmin Liu, Rafael Rojas, Fred C. Lam, Farhan A. Mirza, Anand Mahadevan and Ekkehard M. Kasper
    Citation: Radiation Oncology 2020 15:63
    Content type: Research Published on:

  43. Advances in therapy have resulted in improved cure rates and an increasing number of long-term Hodgkin's lymphoma (HL) survivors. However, radiotherapy (RT)-related late effects are still a significant issue, ...

    Authors: Andrea Riccardo Filippi, Sofia Meregalli, Anna DI Russo, Mario Levis, Patrizia Ciammella, Michela Buglione, Andrea Emanuele Guerini, Giuseppina De Marco, Vitaliana De Sanctis, Stefano Vagge, Umberto Ricardi and Gabriele Simontacchi
    Citation: Radiation Oncology 2020 15:62
    Content type: Review Published on:

  44. Limiting the heart dose in left sided breast cancer radiotherapy is critical. We sought to study the effect of using CPAP (continuous positive airway pressure) as an aid in reducing heart dose in breast cancer...

    Authors: Aaron M. Allen, Yasmin Korzets Ceder, Tzippy Shochat, Eyal Fenig, Aron Popovtzer, Dimitry Bragilofsky, Adi Alfassy and Helena Allon
    Citation: Radiation Oncology 2020 15:59
    Content type: Research Published on:

  46. The aim of the present study was to evaluate MRI response rate and clinical outcome of short-course radiotherapy (SCRT) on rectal cancer as an alternative to chemoradiotherapy in patients where downstaging is ...

    Authors: T. Koëter, S. G. C. van Elderen, G. F. A. J. B. van Tilborg, J. H. W. de Wilt, D. K. Wasowicz, T. Rozema and D. D. E. Zimmerman
    Citation: Radiation Oncology 2020 15:53
    Content type: Research Published on:

  47. Three-dimensional Surface Imaging (3DSI) is a well-established method to objectively monitor morphological changes in the female breast in the field of plastic surgery. In contrast, in radiation oncology we ar...

    Authors: Konstantin Christoph Koban, Lucas Etzel, Zhouxiao Li, Montserrat Pazos, Stephan Schönecker, Claus Belka, Riccardo Enzo Giunta, Thilo Ludwig Schenck and Stefanie Corradini
    Citation: Radiation Oncology 2020 15:52
    Content type: Research Published on:

  48. For stereotactic body radiotherapy (SBRT) to central (C) and ultracentral (UC) lung tumors, our provincial practice has been to prioritize organs at risk (OARs) constraints by compromising target volume covera...

    Authors: Yizhou Zhao, Eman Khawandanh, Steven Thomas, Susan Zhang, Emma M. Dunne, Mitchell Liu and Devin Schellenberg
    Citation: Radiation Oncology 2020 15:61
    Content type: Research Published on:

  49. The literature regarding pericardial effusion after definitive concurrent chemotherapy and intensity modulated radiotherapy (IMRT) for esophageal cancer was lacking. This study aimed to investigate the risk fa...

    Authors: Tzu-Hui Pao, Wei-Lun Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng and Forn-Chia Lin
    Citation: Radiation Oncology 2020 15:48
    Content type: Research Published on:

  50. To investigate the consequences of residual setup error on target dose distribution using various image registration strategies for breast cancer treated with intensity-modulated proton therapy (IMPT).

    Authors: Xiaoying Liang, Raymond B. Mailhot Vega, Zuofeng Li, Dandan Zheng, Nancy Mendenhall and Julie A. Bradley
    Citation: Radiation Oncology 2020 15:47
    Content type: Research Published on:
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Radiation Oncology

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