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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Standard dose of external beam radiotherapy seems to be insufficient for satisfactory control of loco-regionally advanced cervical cancer. Aim of our study is to evaluate the outcome as well as early and chron...

    Authors: Nikola Cihoric, Alexandros Tsikkinis, Coya Tapia, Daniel M. Aebersold, Inti Zlobec and Kristina Lössl
    Citation: Radiation Oncology 2015 10:240
    Content type: Research Published on:

  2. Limited data describe the prognosis after stereotactic ablative radiotherapy for lung metastases arising from colorectal cancer. Thus, we evaluated treatment outcomes of stereotactic ablative radiotherapy for ...

    Authors: Jinhong Jung, Si Yeol Song, Jong Hoon Kim, Chang Sik Yu, Jin Cheon Kim, Tae Won Kim, Seong-Yun Jeong, Su Ssan Kim and Eun Kyung Choi
    Citation: Radiation Oncology 2015 10:238
    Content type: Research Published on:

  3. The purpose of this study was to investigate the role of beam collimator rotation in Volumetric Modulated Arc Therapy (VMAT) for craniospinal irradiation (CSI), and the impact on dose distribution in the beam ...

    Authors: Qilin Li, Wendong Gu, Jinming Mu, Wenming Yin, Min Gao, Juncong Mo and Honglei Pei
    Citation: Radiation Oncology 2015 10:235
    Content type: Methodology Published on:

  5. The most appropriate treatment for men with prostate cancer and positive pelvic nodes, N+, is an area of active controversy. We report our 5-years outcomes in men with locally advanced prostate cancer (T1-T4N0...

    Authors: Wolfgang Lilleby, Amol Narrang, Gunnar Tafjord, Ljiljana Vlatkovic, Kjell Magne Russnes, Andreas Stensvold, Knut HÃ¥kon Hole, Phuoc Tran and Karsten Eilertsen
    Citation: Radiation Oncology 2015 10:232
    Content type: Research Published on:

  6. This study compared VMAT and IMRT plans for intact breast radiotherapy for left sided breast cancer and evaluated the irradiated dose of planning target volume and OARs, especially focusing on heart and corona...

    Authors: Hongfu Zhao, Mingyuan He, Guanghui Cheng, Dongmei Han, Ning Wu, Dan Shi, Zhipeng Zhao and Jianxue Jin
    Citation: Radiation Oncology 2015 10:231
    Content type: Research Published on:

  8. The incidence and associated factors of loose seed migration were investigated in cohort 1 of the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS).

    Authors: Masahiro Nakano, Atsunori Yorozu, Shiro Saito, Akitomo Sugawara, Shinichiroh Maruo, Shinsuke Kojima, Takashi Kikuchi, Masanori Fukushima, Takushi Dokiya and Hidetoshi Yamanaka
    Citation: Radiation Oncology 2015 10:228
    Content type: Research Published on:

  9. This study evaluated an automated inverse treatment planning algorithm, Pinnacle Auto-Planning (AP), and compared automatically generated plans with historical plans in a large cohort of head and neck cancer p...

    Authors: Jerome Krayenbuehl, Ian Norton, Gabriela Studer and Matthias Guckenberger
    Citation: Radiation Oncology 2015 10:226
    Content type: Research Published on:

  10. Shortening the overall treatment time without increasing acute reactions is one of the major aims in radiotherapy for head and neck cancer (HNC). Volumetric modulated arc therapy (VMAT) with Simultaneous Integ...

    Authors: Ciro Franzese, Antonella Fogliata, Elena Clerici, Davide Franceschini, Elisa Villa, Giuseppe D’Agostino, Piera Navarria, Pietro Mancosu, Stefano Tomatis, Luca Cozzi and Marta Scorsetti
    Citation: Radiation Oncology 2015 10:224
    Content type: Research Published on:

  11. Dexamethasone (DXM) is commonly used in the management of cerebral edema in patients diagnosed with glioblastoma multiforme (GBM). Bevacizumab (BEV) is FDA-approved for the progression or recurrence of GBM but...

    Authors: Lisa B. E. Shields, Brent J. Shelton, Andrew J. Shearer, Li Chen, David A. Sun, Sarah Parsons, T. David Bourne, Renato LaRocca and Aaron C. Spalding
    Citation: Radiation Oncology 2015 10:222
    Content type: Research Published on:

  12. Stereotactic radiosurgery (SRS) is an alternative to post-operative whole brain radiation therapy (WBRT) following resection of brain metastases. At our institution, CyberKnife (CK) is considered for local tre...

    Authors: Jennifer Vogel, Eric Ojerholm, Andrew Hollander, Cynthia Briola, Rob Mooij, Michael Bieda, James Kolker, Suneel Nagda, Geoffrey Geiger, Jay Dorsey, Robert Lustig, Donald M. O’Rourke, Steven Brem, John Lee and Michelle Alonso-Basanta
    Citation: Radiation Oncology 2015 10:221
    Content type: Research Published on:

  13. Radiotherapy is associated with a risk of subsequent neoplasms (SN) in childhood cancer survivors. It has been shown that children’s thyroid glands are especially susceptible. The aim is to quantify the risk o...

    Authors: Isabelle Finke, Peter Scholz-Kreisel, Ulrike Hennewig, Maria Blettner and Claudia Spix
    Citation: Radiation Oncology 2015 10:219
    Content type: Research Published on:

  14. We report the radiographic response rate of SBRT compared to conventional fractionated radiotherapy (CF-EBRT) for thoracic, abdominal, skin and soft tissue RCC lesions treated at our institution.

    Authors: Basel Altoos, Arya Amini, Muthanna Yacoub, Maria T. Bourlon, Elizabeth E. Kessler, Thomas W. Flaig, Christine M. Fisher, Brian D. Kavanagh, Elaine T. Lam and Sana D. Karam
    Citation: Radiation Oncology 2015 10:218
    Content type: Research Published on:

  15. The patient positioning in pelvic radiotherapy (RT) should be decided based on both reproducibility and on which position that yields the lowest radiation dose to the organs at risk (OAR), and thereby less sid...

    Authors: Trude C. Frøseth, Trond Strickert, Kjersti S. Solli, Øyvind Salvesen, Gunilla Frykholm and Randi J. Reidunsdatter
    Citation: Radiation Oncology 2015 10:217
    Content type: Research Published on:

  16. Achieving durable local control while limiting normal tissue toxicity with definitive radiation therapy in the management of high-risk brain metastases remains a radiobiological challenge. The objective of thi...

    Authors: Jonathan W. Lischalk, Eric Oermann, Sean P. Collins, Mani N. Nair, Vikram V. Nayar, Richa Bhasin, Jean-Marc Voyadzis, Sonali Rudra, Keith Unger and Brian T. Collins
    Citation: Radiation Oncology 2015 10:216
    Content type: Research Published on:

  17. The use of a tissue expander (hydrogel) for sparing of the rectum from increased irradiation during prostate radiotherapy is becoming popular. The goal of this study is to investigate the effect of a tissue ex...

    Authors: Prabhjot Juneja, Andrew Kneebone, Jeremy T. Booth, David I. Thwaites, Ramandeep Kaur, Emma Colvill, Jin A. Ng, Paul J. Keall and Thomas Eade
    Citation: Radiation Oncology 2015 10:215
    Content type: Research Published on:

  18. We conducted a retrospective analysis on 884 patients who were diagnosed with esophageal squamous cell carcinoma (ESCC) and treated with either the neutron brachytherapy in combination with external beam radio...

    Authors: Qifeng Wang, Tao Li, Jinyi Lang, Jie Wang, Jian Wang, Huiming Liu, Xitang Jia, Bo Liu and C-K Chris Wang
    Citation: Radiation Oncology 2015 10:212
    Content type: Research Published on:

  19. The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspart...

    Authors: Petr Pospisil, Tomas Kazda, Martin Bulik, Marie Dobiaskova, Petr Burkon, Ludmila Hynkova, Pavel Slampa and Radim Jancalek
    Citation: Radiation Oncology 2015 10:211
    Content type: Research Published on:

  20. This study aimed to elucidate the influence of skin invasion in patients with recurrent head and neck cancer treated with re-irradiation using stereotactic radiotherapy.

    Authors: Hideya Yamazaki, Mikio Ogita, Kengo Himei, Satoaki Nakamura, Gen Suzuki, Tadayuki Kotsuma, Ken Yoshida and Yasuo Yoshioka
    Citation: Radiation Oncology 2015 10:210
    Content type: Research Published on:

  21. Accelerated partial breast irradiation (APBI) is an option for adjuvant radiotherapy according to ASTRO and ESTRO recommendations. Among the available techniques, volumetric-modulated arc therapy (VMAT) is att...

    Authors: Olivier Riou, Pascal Fenoglietto, Céline Bourgier, Olivier Lauche, Fatiha Boulbair, Marie Charissoux, Angélique Ducteil, Norbert Aillères, Claire Lemanski and David Azria
    Citation: Radiation Oncology 2015 10:209
    Content type: Research Published on:

  23. Glioblastoma multiforme is the most common and most aggressive malign brain tumor. The 5-year survival rate after tumor resection and adjuvant chemoradiation is only 10 %, with almost all recurrences occurring...

    Authors: Lukas Winter, Celal Oezerdem, Werner Hoffmann, Tessa van de Lindt, Joao Periquito, Yiyi Ji, Pirus Ghadjar, Volker Budach, Peter Wust and Thoralf Niendorf
    Citation: Radiation Oncology 2015 10:201
    Content type: Research Published on:

  24. Deep inspiration breath hold (DIBH) reduces heart and left anterior descending artery (LAD) dose during left-sided breast radiation therapy (RT); however there is limited information about which patients deriv...

    Authors: Rosanna Yeung, Leigh Conroy, Karen Long, Daphne Walrath, Haocheng Li, Wendy Smith, Alana Hudson and Tien Phan
    Citation: Radiation Oncology 2015 10:200
    Content type: Research Published on:

  25. In patients at high risk for regional node metastasis from squamous cell carcinoma (SCC) of the skin of the face, ear, or scalp, radiotherapy to the regional nodes is an alternative to parotid or neck surgery....

    Authors: Justin Wray, Robert J. Amdur, Christopher G. Morris, John Werning and William M. Mendenhall
    Citation: Radiation Oncology 2015 10:199
    Content type: Research Published on:

  26. Radiotherapy (RT) is one of the major non-operative treatment modalities for treating lung cancer. Tomotherapy is an advanced type of intensity-modulated radiotherapy (IMRT) in which radiation may be delivered...

    Authors: Xianglan Zhang, You Keun Shin, Zhenlong Zheng, Lianhua Zhu and Ik Jae Lee
    Citation: Radiation Oncology 2015 10:195
    Content type: Research Published on:

  27. Radiation-induced tinnitus is a side effect of radiotherapy in the inner ear for cancers of the head and neck. Effective dose constraints for protecting the cochlea are under-reported. The aim of this study is...

    Authors: Tsair-Fwu Lee, Shyh-An Yeh, Pei-Ju Chao, Liyun Chang, Chien-Liang Chiu, Hui-Min Ting, Hung-Yu Wang and Yu-Jie Huang
    Citation: Radiation Oncology 2015 10:194
    Content type: Research Published on:

  28. Frameless immobilization allows for planning and quality assurance of intensity-modulated radiosurgery (IM-SRS) plans. We tested the hypothesis that IM-SRS planning with uniform tissue density corrections resu...

    Authors: Lisa B. E. Shields, Cindy Bond, Aaron Odom, David A. Sun and Aaron C. Spalding
    Citation: Radiation Oncology 2015 10:193
    Content type: Research Published on:

  29. To determine appropriate timing of an adaptive radiation therapy (ART) replan by evaluating anatomic and dosimetric changes of target volumes and organs at risk (OARs) during intensity-modulated radiation ther...

    Authors: Huixian Huang, Heming Lu, Guosheng Feng, Hailan Jiang, Jiaxin Chen, Jinjian Cheng, Qiang Pang, Zhiping Lu, Junzhao Gu, Luxing Peng, Shan Deng, Ying Mo, Danling Wu and Yinglin Wei
    Citation: Radiation Oncology 2015 10:192
    Content type: Research Published on:

  30. The aim of this study was to evaluate the disease outcomes of patients treated with definitive and adjuvant radiotherapy for squamous cell carcinomas of the nasal cavity and paranasal sinuses in a single insti...

    Authors: Sumerya Duru Birgi, Mark Teo, Karen E. Dyker, Mehmet Sen and Robin J D Prestwich
    Citation: Radiation Oncology 2015 10:190
    Content type: Research Published on:

  31. This study assessed the survival outcomes and recurrent patterns in pelvic node-positive IB1-IIA2 cervical cancer patients treated with postoperative external beam irradiation with or without vaginal brachythe...

    Authors: Lei Li, XinXin Kou, XiaoJie Feng, MingChuan Zhang, HongTu Chao and LiYing Wang
    Citation: Radiation Oncology 2015 10:189
    Content type: Research Published on:

  32. To consolidate literature reports of serious late gastrointestinal toxicities after hypofractionated radiation treatment of pancreatic cancer and attempt to derive normal tissue complication probability (NTCP)...

    Authors: Adnan Elhammali, Mukund Patel, Benjamin Weinberg, Vivek Verma, Jingxia Liu, Jeffrey R. Olsen and Hiram A. Gay
    Citation: Radiation Oncology 2015 10:186
    Content type: Research Published on:

  33. To investigate the feasibility of DWI in evaluating early therapeutic response of uterine cervical cancer to concurrent chemoradiation (CCR) and establish optimal time window for early detection of treatment r...

    Authors: Ying Liu, Haoran Sun, Renju Bai and Zhaoxiang Ye
    Citation: Radiation Oncology 2015 10:185
    Content type: Research Published on:

  34. The impact of multileaf collimator (MLC) design and IMRT technique on plan quality and delivery improvements for head-and-neck and meningioma patients is compared in a planning study.

    Authors: Steffi Kantz, Matthias Söhn, Almut Troeller, Michael Reiner, Helmut Weingandt, Markus Alber, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2015 10:184
    Content type: Research Published on:

  35. Urinary symptoms and sexual dysfunction are the two most common complaints following prostate radiotherapy. The impact of hypofractionated treatment on sexual function, irritative symptoms, and voiding symptom...

    Authors: Zaker Rana, Robert L. Hong, Mustafa Abugideiri, Donald McRae, George Cernica, Robert Mordkin, Andrew B. Joel, Gregory Bernstein and Nadim M. Nasr
    Citation: Radiation Oncology 2015 10:182
    Content type: Research Published on:

  37. The purpose of this study is to report our clinical outcomes using intensity-modulated radiation therapy (IMRT) for adjuvant treatment of cervical cancer, compared with three-dimensional conformal radiation th...

    Authors: Fumiaki Isohashi, Seiji Mabuchi, Yasuo Yoshioka, Yuji Seo, Osamu Suzuki, Keisuke Tamari, Michiko Yamashita, Hikari Unno, Yasuto Kinose, Katsumi Kozasa, Iori Sumida, Yuki Otani, Tadashi Kimura and Kazuhiko Ogawa
    Citation: Radiation Oncology 2015 10:180
    Content type: Research Published on:

  38. Whole breast irradiation after conserving surgery for breast cancer requires precise definition of the target volume. The standard approach uses computed tomography (CT) images. However, since fatty breast and...

    Authors: Cynthia Aristei, Isabella Palumbo, Lorenzo Falcinelli, Rossana Crisci, Laura Cardinali, Barbara Palumbo, Valentina Lancellotta, Giampaolo Montesi, Gianni Gobbi, Claudio Zucchetti and Vittorio Bini
    Citation: Radiation Oncology 2015 10:179
    Content type: Research Published on:

  39. The aim of the present work was to analyse the impact of mild hypofractionated radiotherapy (RT) of infra-supraclavicular lymph nodes after axillary dissection on late toxicity.

    Authors: Marina Guenzi, Gladys Blandino, Maria Giuseppina Vidili, Deborah Aloi, Elena Configliacco, Elisa Verzanini, Elena Tornari, Francesca Cavagnetto and Renzo Corvò
    Citation: Radiation Oncology 2015 10:177
    Content type: Research Published on:

  40. To compare thermoplastic masks (TMP) and vacuum cushion system (VCS) to assess differences in interfraction set up accuracy in patients treated with stereotactic radiotherapy (SBRT) for oligometastatic lung ca...

    Authors: Arturo Navarro-Martin, Jon Cacicedo, Olwen Leaman, Ismael Sancho, Elvira García, Valentin Navarro and Ferran Guedea
    Citation: Radiation Oncology 2015 10:176
    Content type: Research Published on:

  41. Our first trial on radiotherapy for painful heel spur published in 2012 comparing the analgesic effect of a standard dose (6 × 1.0Gy within three weeks) to that of a very low one (6 × 0.1Gy within three weeks)...

    Authors: Marcus Niewald, Henrik Holtmann, Benjamin Prokein, Matthias G. Hautmann, Hans-Peter Rösler, Stefan Graeber, Yvonne Dzierma, Christian Ruebe and Jochen Fleckenstein
    Citation: Radiation Oncology 2015 10:174
    Content type: Research Published on:

  42. Elderly patients become more important in oncology. In this group, personalized treatment approaches taking into account survival prognoses and comorbidities play a major role. Predictive instruments are neces...

    Authors: Dirk Rades, Antonio J. Conde, Raquel Garcia, Jon Cacicedo, Barbara Segedin, Ana Perpar and Steven E. Schild
    Citation: Radiation Oncology 2015 10:173
    Content type: Research Published on:

  43. A time factor of radiooncological treatment has been demonstrated for several tumours, most prominently for head and neck squamous cell carcinoma and lung cancer. In glioblastoma multiforme studies of the impa...

    Authors: Annekatrin Seidlitz, Timo Siepmann, Steffen Löck, Tareq Juratli, Michael Baumann and Mechthild Krause
    Citation: Radiation Oncology 2015 10:172
    Content type: Research Published on:

  44. This retrospective study on early and locally advanced esophageal cancer was conducted to evaluate locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective ...

    Authors: Hideomi Yamashita, Ryousuke Takenaka, Mami Omori, Toshikazu Imae, Kae Okuma, Kuni Ohtomo and Keiichi Nakagawa
    Citation: Radiation Oncology 2015 10:171
    Content type: Research Published on:

  45. To assess feasibility and toxicity of Helical TomoTherapy® for treating anal cancer patients.

    Authors: V. Vendrely, B. Henriques de Figueiredo, E. Rio, J. Benech, S. Belhomme, A. Lisbona, E. Frison, A. Doussau, N. Nomikossoff, M. A. Mahé, G. Kantor and J. P. Maire
    Citation: Radiation Oncology 2015 10:170
    Content type: Research Published on:

  46. There is growing recognition for the consequences of rectal cancer treatment to maintain an adequate functional sphincter in the long-term rather than preserving the anal sphincter itself. This study aims to e...

    Authors: Zerrin Ozgen, Sevgi Ozden, Beste M Atasoy, Hazan Ozyurt, Rasim Gencosmanoglu and Nese Imeryuz
    Citation: Radiation Oncology 2015 10:168
    Content type: Research Published on:

  47. To investigate acute and late toxicities comparing sequential (SEQ-IMRT) versus simultaneous integrated boost intensity modulated radiotherapy (SIB-IMRT) in nasopharyngeal carcinoma (NPC) patients.

    Authors: Anussara P. Songthong, Danita Kannarunimit, Chakkapong Chakkabat and Chawalit Lertbutsayanukul
    Citation: Radiation Oncology 2015 10:166
    Content type: Research Published on:

  48. The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against ...

    Authors: Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken and Przemek M. Krawczyk
    Citation: Radiation Oncology 2015 10:165
    Content type: Research Published on:

  49. To identify dosimetric parameters associated with acute hematologic toxicity (HT) in rectal cancer patients undergoing concurrent chemotherapy and intensity-modulated pelvic radiotherapy.

    Authors: Juefeng Wan, Kaitai Liu, Kaixuan Li, Guichao Li and Zhen Zhang
    Citation: Radiation Oncology 2015 10:162
    Content type: Research Published on:

  50. Several randomized trials and meta-analyses confirmed a wide benefit of radiotherapy (RT), both after breast conserving surgery (BCS) and mastectomy. However, many elderly women don't receive RT. Hypofractiona...

    Authors: Mélanie Doré, Bruno Cutuli, Patrice Cellier, Loïc Campion and Magali Le Blanc
    Citation: Radiation Oncology 2015 10:161
    Content type: Research Published on:
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Radiation Oncology

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