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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Definitive radiotherapy is often used for chest wall desmoid tumours due to size or anatomical location. The delivery of radiotherapy is challenging due to the large size and constraints of normal surrounding ...

    Authors: Jia Liu, Diana Ng, James Lee, Paul Stalley and Angela Hong
    Citation: Radiation Oncology 2016 11:34
    Content type: Short report Published on:

  2. The aim of this study was to investigate the potential of the flattening filter free (FFF) mode of a linear accelerator for intensity modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VM...

    Authors: Barbara Dobler, Amine Khemissi, Tina Obermeier, Matthias G. Hautmann, Zaira Katsilieri and Oliver Kölbl
    Citation: Radiation Oncology 2016 11:33
    Content type: Research Published on:

  3. To evaluate acute toxicity endpoints in a cohort of patients receiving head and neck radiation with proton therapy or intensity modulated radiation therapy (IMRT).

    Authors: Mark W. McDonald, Yuan Liu, Michael G. Moore and Peter A. S. Johnstone
    Citation: Radiation Oncology 2016 11:32
    Content type: Research Published on:

  4. Salvage endoscopic therapy (SET), such as endoscopic mucosal resection (EMR) and photodynamic therapy (PDT), is a less-invasive treatment for local failure at the primary site after chemoradiotherapy (CRT) for...

    Authors: Ken Hatogai, Tomonori Yano, Takashi Kojima, Masakatsu Onozawa, Satoshi Fujii, Hiroyuki Daiko, Yusuke Yoda, Takuya Hombu, Toshihiko Doi, Kazuhiro Kaneko and Atsushi Ohtsu
    Citation: Radiation Oncology 2016 11:31
    Content type: Research Published on:

  5. Radiotherapy of central lung tumors carries a higher risk of treatment-related toxicity and local failure. In the era of aggressive oligometastic management the exploration of the proper dose-fractionation for...

    Authors: Jonathan W. Lischalk, Ryan M. Malik, Sean P. Collins, Brian T. Collins, Ismael A. Matus and Eric D. Anderson
    Citation: Radiation Oncology 2016 11:28
    Content type: Research Published on:

  6. To analyse and compare the costs of hepatic tumor ablation with computed tomography (CT)-guided high-dose rate brachytherapy (CT-HDRBT) and CT-guided radiofrequency ablation (CT-RFA) as two alternative minimal...

    Authors: D. Schnapauff, F. Collettini, I. Steffen, G. Wieners, B. Hamm, B. Gebauer and M. H. Maurer
    Citation: Radiation Oncology 2016 11:26
    Content type: Research Published on:

  7. To evaluate the efficacy of postoperative radiotherapy (RT) on local failure-free survival (LFFS), distant metastasis-free survival (DMFS) and overall survival (OS) in patients with localized primary soft tiss...

    Authors: Ru-Ping Zhao, Xiao-Li Yu, Zhen Zhang, Li-Juan Jia, Yan Feng, Zhao-Zhi Yang, Xing-Xing Chen, Jian Wang, Sheng-Lin Ma and Xiao-Mao Guo
    Citation: Radiation Oncology 2016 11:25
    Content type: Research Published on:

  8. Neoadjuvant CRT may lead to significant tumor regression in patients with rectal cancer. Different CRT regimens with consolidation chemotherapy may lead to increased rates of complete tumor regression. The pur...

    Authors: Angelita Habr-Gama, Rodrigo O. Perez, Guilherme P. São Julião, Igor Proscurshim, Laura M. Fernandez, Marleny N. Figueiredo, Joaquim Gama-Rodrigues and Carlos A. Buchpiguel
    Citation: Radiation Oncology 2016 11:24
    Content type: Research Published on:

  9. The aim of this work is to develop an algorithm to predict recurrence in prostate cancer patients treated with radical radiotherapy, getting up to a prognostic power higher than traditional D’Amico risk classi...

    Authors: Domenico Gabriele, Barbara A Jereczek-Fossa, Marco Krengli, Elisabetta Garibaldi, Maria Tessa, Gregorio Moro, Giuseppe Girelli and Pietro Gabriele
    Citation: Radiation Oncology 2016 11:23
    Content type: Research Published on:

  10. This study aimed to evaluate the effect of stereotactic ablative radiotherapy (SABR) after incomplete transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients.

    Authors: Eun Kyung Paik, Mi-Sook Kim, Won Il Jang, Young Seok Seo, Chul-Koo Cho, Hyung Jun Yoo, Chul Ju Han, Su Cheol Park, Sang Bum Kim and Young Han Kim
    Citation: Radiation Oncology 2016 11:22
    Content type: Research Published on:

  11. The benefit of hyperthermia as a potent modifier of radiotherapy has been well established and more recently also the combination with chemotherapy was shown beneficial. Also for head and neck cancer, the impa...

    Authors: Margarethus M. Paulides, Gerda M. Verduijn and Netteke Van Holthe
    Citation: Radiation Oncology 2016 11:21
    Content type: Review Published on:

  12. The relationship between oesophageal radiation dose volume metrics and dysphagia in patients having chemoradiation (CRT) for non-small cell lung cancer (NSCLC) is well established. There is also some evidence ...

    Authors: Sarah Everitt, Mary Duffy, Mathias Bressel, Belinda McInnes, Christine Russell, Tim Sevitt and David Ball
    Citation: Radiation Oncology 2016 11:20
    Content type: Research Published on:

  13. The first aim of this study was to assess plan quality using a conformity index (CI) and analyse its influence on patient outcome. The second aim was to identify whether clinical and technological factors incl...

    Authors: Rhys Carrington, Emiliano Spezi, Sarah Gwynne, Peter Dutton, Chris Hurt, John Staffurth and Thomas Crosby
    Citation: Radiation Oncology 2016 11:19
    Content type: Research Published on:

  15. Radiotherapy has a central role in the treatment of sinonasal malignancies, either as postoperative or as primary therapy. To study the efficacy and safety of intensity modulated radiotherapy (IMRT) for sinona...

    Authors: Vasileios Askoxylakis, Pia Hegenbarth, Carmen Timke, Ladan Saleh-Ebrahimi, Juergen Debus, Falk Röder and Peter E. Huber
    Citation: Radiation Oncology 2016 11:17
    Content type: Research Published on:

  18. To assess efficacy of our single-centre experience with inhalative steroids (IS) in lung cancer patients with symptomatic radiation pneumonitis (RP) grade II.

    Authors: C. Henkenberens, S. Janssen, M. Lavae-Mokhtari, K. Leni, A. Meyer, H. Christiansen, M. Bremer and N. Dickgreber
    Citation: Radiation Oncology 2016 11:12
    Content type: Research Published on:

  19. A new entity of patients with recurrent prostate cancer limited to a small number of active metastatic lesions is having growing interest: the oligometastatic patients. Patients with oligometastatic disease co...

    Authors: Francesco Pasqualetti, Marco Panichi, Aldo Sainato, Fabrizio Matteucci, Luca Galli, Paola Cocuzza, Patrizia Ferrazza, Gabriele Coraggio, Giuseppe Pasqualetti, Lisa Derosa, Martina Sollini, Lorenzo Mannelli, Simona Ortori, Fabio Monzani, Sergio Ricci, Carlo Greco…
    Citation: Radiation Oncology 2016 11:9
    Content type: Research Published on:

  20. Treatment of intermediate and high-risk prostate cancer with a high BED has been shown to increase recurrence free survival (RFS). While high dose rate (HDR) brachytherapy, given as a boost is effective in del...

    Authors: Mekhail Anwar, Vivian Weinberg, Zachary Seymour, I. Joe Hsu, Mack Roach III and Alex R. Gottschalk
    Citation: Radiation Oncology 2016 11:8
    Content type: Research Published on:

  21. The EORTC has launched a phase II trial to assess safety and efficacy of SBRT for centrally located NSCLC: The EORTC 22113-08113—Lungtech trial. Due to neighbouring critical structures, these tumours remain ch...

    Authors: Marie Lambrecht, Christos Melidis, Jan-Jakob Sonke, Sonja Adebahr, Ronald Boellaard, Marcel Verheij, Matthias Guckenberger, Ursula Nestle and Coen Hurkmans
    Citation: Radiation Oncology 2016 11:7
    Content type: Research Published on:

  22. After the failure of first-line treatment, the clinical prognosis in head and neck cancer (HNSCC) deteriorates. Effective therapeutic strategies are limited due to the toxicity of previous treatments and the d...

    Authors: M. Ritter, I. U. Teudt, J. E. Meyer, U. Schröder, G. Kovács and B. Wollenberg
    Citation: Radiation Oncology 2016 11:6
    Content type: Research Published on:

  23. To evaluate clinical outcomes of stereotactic body radiotherapy (SBRT) for localized primary and oligometastatic lung tumors by assessing efficacy and safety of 5 regimens of varying fraction size and number.

    Authors: Masahiko Aoki, Yoshiomi Hatayama, Hideo Kawaguchi, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Ichitaro Fujioka, Shuichi Ono, Eiki Tsushima and Yoshihiro Takai
    Citation: Radiation Oncology 2016 11:5
    Content type: Research Published on:

  24. Standard chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is an optional treatment for patients with stage II-III esophageal cancer. However, there are some demerits in this regimen bec...

    Authors: Hideomi Yamashita, Akihiro Haga, Ryousuke Takenaka, Tomoki Kiritoshi, Kae Okuma, Kuni Ohtomo and Keiichi Nakagawa
    Citation: Radiation Oncology 2016 11:4
    Content type: Research Published on:

  25. Hypofractionated three-dimensional conformal radiation therapy (3D-CRT) is a treatment option for patients with early-stage non-small cell lung cancer (NSCLC) who are medically unable to tolerate surgery and w...

    Authors: Masakuni Sakaguchi, Toshiya Maebayashi, Takuya Aizawa, Naoya Ishibashi, Shoko Fukushima, Osamu Abe and Tsutomu Saito
    Citation: Radiation Oncology 2016 11:3
    Content type: Research Published on:

  26. To verify the accuracy of volumetric arc therapy (VMAT) using the RapidArcâ„¢ device when switching patients from one single linear accelerator (linac) to a paired energy and mechanics "twin" linac without reopt...

    Authors: P. Fenoglietto, M. Khodri, D. Nguyen, F. Josserand-Pietri and N. Aillères
    Citation: Radiation Oncology 2016 11:2
    Content type: Research Published on:

  27. We investigated the clinical outcome and the toxicity of trimodal therapy of malignant pleural mesothelioma (MPM) treated with neoadjuvant chemotherapy, extrapleural pneumonectomy (EPP) and adjuvant intensity-...

    Authors: Christian Thieke, Nils H. Nicolay, Florian Sterzing, Hans Hoffmann, Falk Roeder, Seyer Safi, Juergen Debus and Peter E. Huber
    Citation: Radiation Oncology 2015 10:267
    Content type: Research Published on:

  28. Total body irradiation (TBI) has been part of standard conditioning regimens before allogeneic stem cell transplantation for many years. Its effect on normal tissue in these patients has not been studied exten...

    Authors: G. Massenkeil, P. Zschieschang, G. Thiel, P. G. Hemmati, V. Budach, B. Dörken, J. Pross and R. Arnold
    Citation: Radiation Oncology 2015 10:266
    Content type: Research Published on:

  29. Around 27,000 new cases of prostate cancer are diagnosed every year in Spain and 5400 die from this disease. Radiotherapy (RT), alone or combined, has proven to be effective as initial treatment in patients wi...

    Authors: José Expósito, Isabel Linares, Isabel Castillo, Miguel Martínez, Pilar Vargas, Ismael Herruzo, José Antonio Medina, Amalia Palacios, Eloísa Bayo, Francisco Peracaula, Javier Jaén, José Antonio Sánchez and María José Ortiz
    Citation: Radiation Oncology 2015 10:265
    Content type: Research Published on:

  30. Radiation therapy (RT) for a left-sided breast cancer often involves some incidental exposure of the heart and increase in the rate of major coronary events. One method to reduce the dose to the heart during a...

    Authors: Ji Hyeon Joo, Su Ssan Kim, Seung Do Ahn, Jungwon Kwak, Chiyoung Jeong, Sei-Hyun Ahn, Byung-Ho Son and Jong Won Lee
    Citation: Radiation Oncology 2015 10:264
    Content type: Research Published on:

  31. Little is known about the clinical impact of using multiparametric MRI to plan early salvage radiotherapy after radical prostatectomy. We aimed to evaluate the incidence and location of recurrence based on pel...

    Authors: D. Hernandez, D. Salas, D. Giménez, P. Buitrago, S. Esquena, J. Palou, P. de la Torre, J. Pernas, I. Gich, G. Gómez de Segura, J. Craven-Bartle and G. Sancho
    Citation: Radiation Oncology 2015 10:262
    Content type: Research Published on:

  32. The last few years, in radiotherapy there has been a growing focus on speed of treatment delivery (largely driven by economical and commercial interests). This study investigates the influence of treatment tim...

    Authors: Dirk Van Gestel, Geert De Kerf, Kristien Wouters, Wouter Crijns, Jan B. Vermorken, Vincent Gregoire and Dirk Verellen
    Citation: Radiation Oncology 2015 10:261
    Content type: Research Published on:

  33. The present study aimed to measure the effect of a morphometric atlas selection strategy on the accuracy of multi-atlas-based BP autosegmentation using the commercially available software package ADMIRE® and t...

    Authors: Joris Van de Velde, Johan Wouters, Tom Vercauteren, Werner De Gersem, Eric Achten, Wilfried De Neve and Tom Van Hoof
    Citation: Radiation Oncology 2015 10:260
    Content type: Research Published on:

  34. The results of treatment for malignant bone and soft-tissue tumors arising from the deep trunk and pelvis are still not acceptable due to the relatively high recurrence and low overall survival rates. Recently...

    Authors: Takashi Yanagawa, Kenichi Saito, Hiroki Kiyohara, Tatsuya Ohno, Takashi Nakano and Kenji Takagishi
    Citation: Radiation Oncology 2015 10:259
    Content type: Research Published on:

  35. Adjuvant radiotherapy (RT) of regional lymph nodes (LN) in early breast cancer is still a matter of debate. RT increases the Overall survival (OS) rate of breast cancer patients after breast conserving surgery...

    Authors: Wilfried Budach, Edwin Bölke, Kai Kammers, Peter Arne Gerber, Carolin Nestle-Krämling and Christiane Matuschek
    Citation: Radiation Oncology 2015 10:258
    Content type: Research Published on:

  36. The small bowel (SB) represents the most important dose-limiting structure in pelvic radiotherapy (RT). However, we observed that the majority of rectal cancer patients who received preoperative pelvic intensi...

    Authors: Benhua Xu, Yuyan Guo, Yuangui Chen, Haijie Lu, Tianlan Tang, Zhicao Yue, Guoxian Guan, Pan Chi and Chi Lin
    Citation: Radiation Oncology 2015 10:257
    Content type: Research Published on:

  37. Radio-chemotherapy is one of the steps of multidisciplinary management in locally advanced pancreatic cancer. The Epidermal Growth Factor Receptor (EGFR) plays an important role in the disease pathway. The pur...

    Authors: Michele Fiore, Lucio Trodella, Sergio Valeri, Domenico Borzomati, Barnaba Floreno, Edy Ippolito, Pasquale Trecca, Luca Eolo Trodella, Rolando Maria D’Angelillo, Sara Ramella and Roberto Coppola
    Citation: Radiation Oncology 2015 10:255
    Content type: Research Published on:

  38. Registering CTs for patients receiving external beam radiotherapy (EBRT) with a boost dose from high-dose-rate brachytherapy (HDR) can be challenging due to considerable image discrepancies (e.g. rectal fillin...

    Authors: Calyn R. Moulton, Michael J. House, Victoria Lye, Colin I. Tang, Michele Krawiec, David J. Joseph, James W. Denham and Martin A. Ebert
    Citation: Radiation Oncology 2015 10:254
    Content type: Research Published on:

  39. Whole brain radiotherapy (WBRT) has been the treatment of choice for patients with brain metastases. However, change/decline of neurocognitive functions (NCFs) resulting from impaired hippocampal neurogenesis ...

    Authors: Ping-Fang Tsai, Chi-Cheng Yang, Chi-Cheng Chuang, Ting-Yi Huang, Yi-Ming Wu, Ping-Ching Pai, Chen-Kan Tseng, Tung-Ho Wu, Yi-Liang Shen and Shinn-Yn Lin
    Citation: Radiation Oncology 2015 10:253
    Content type: Research Published on:

  40. Cervical cancer is associated with a high yearly mortality. The presence of persistent disease after radiotherapy is a significant predictor of patient survival.

    Authors: J. E. Mongula, B. F. M. Slangen, D. M. J. Lambregts, F. Cellini, F. C. H. Bakers, L. C. H. W. Lutgens, T. Van Gorp, A.J. Kruse, R. F. P. M. Kruitwagen and R. G. H. Beets-Tan
    Citation: Radiation Oncology 2015 10:252
    Content type: Research Published on:

  41. To report our long-term results with postoperative intensity-modulated radiation therapy (IMRT) in patients suffering from squamous-cell carcinoma (SCC) of the oral cavity or oropharynx.

    Authors: M. Hoffmann, L. Saleh-Ebrahimi, F. Zwicker, P. Haering, A. Schwahofer, J. Debus, P.E. Huber and F. Roeder
    Citation: Radiation Oncology 2015 10:251
    Content type: Research Published on:

  42. Elderly patients with non-small cell lung cancer (NSCLC) are frequently treated with radiation therapy (RT) alone, due to poor performance status or underlying disease. We investigated the effectiveness of RT ...

    Authors: Ji Hyeon Joo, Si Yeol Song, Su Ssan Kim, Yuri Jeong, Seong-Yun Jeong, Wonsik Choi and Eun Kyung Choi
    Citation: Radiation Oncology 2015 10:250
    Content type: Research Published on:

  43. Stereotactic radiosurgery (SRS) alone is an increasingly common treatment strategy for brain metastases. However, existing prognostic tools for overall survival (OS) were developed using cohorts of patients tr...

    Authors: Imran H. Chowdhury, Eric Ojerholm, Matthew T. McMillan, Denise Miller, James D. Kolker, Goldie Kurtz, Jay F. Dorsey, Suneel N. Nagda, Geoffrey A. Geiger, Steven Brem, Donald M. O’Rourke, Eric L. Zager, Tara Gangadhar, Lynn Schuchter, John Y. K. Lee and Michelle Alonso-Basanta
    Citation: Radiation Oncology 2015 10:248
    Content type: Research Published on:

  44. Plan adaptation during the course of (chemo)radiotherapy of H&N cancer requires repeat CT scanning to capture anatomy changes such as parotid gland shrinkage. Hydration, applied to prevent nephrotoxicity from ...

    Authors: Petronella M. Kager, Sanne C. C. van Weerdenburg, Simon R. van Kranen, Suzanne van Beek, Elisabeth A. Lamers-Kuijper, Wilma D. Heemsbergen, Olga Hamming-Vrieze and Peter Remeijer
    Citation: Radiation Oncology 2015 10:246
    Content type: Research Published on:

  45. Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiat...

    Authors: Anand Mahadevan, Carrie Sampson, Salvatore LaRosa, Scott R. Floyd, Eric T. Wong, Erik J. Uhlmann, Soma Sengupta and Ekkehard M. Kasper
    Citation: Radiation Oncology 2015 10:245
    Content type: Research Published on:

  46. Our purpose was to analyze the long-term clinical outcome and to identify prognostic factors after Linac-based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) on patients with ...

    Authors: David Kaul, Alexander Angelidis, Volker Budach, Pirus Ghadjar, Markus Kufeld and Harun Badakhshi
    Citation: Radiation Oncology 2015 10:244
    Content type: Research Published on:

  47. A prospective clinical trial was conducted to evaluate the feasibility of a novel approach to the treatment of patients with high risk prostate cancer (HRPC) through the use of a nomogram to tailor radiotherap...

    Authors: Raymond Wu, Hannah Woodford, Anne Capp, Perry Hunter, Gary Cowin, Keen-Hun Tai, Paul L. Nguyen, Peter Chong and Jarad Martin
    Citation: Radiation Oncology 2015 10:243
    Content type: Research Published on:

  49. To report on the acute toxicity in children with medulloblastoma undergoing intensity-modulated radiation therapy (IMRT) with daily intrafractionally modulated junctions.

    Authors: Maurice C. Cox, Johannes M. Kusters, Corrie E. Gidding, Jolanda H. Schieving, Erik J. van Lindert, Johannes H. Kaanders and Geert O. Janssens
    Citation: Radiation Oncology 2015 10:241
    Content type: Research Published on:

  50. Magnetic resonance imaging (MRI) has been incorporated as an adjunct to CT to take advantage of its excellent soft tissue contrast for contouring. MR-only treatment planning approaches have been developed to a...

    Authors: Joshua Kim, Kim Garbarino, Lonni Schultz, Kenneth Levin, Benjamin Movsas, M. Salim Siddiqui, Indrin J. Chetty and Carri Glide-Hurst
    Citation: Radiation Oncology 2015 10:239
    Content type: Research Published on:
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Radiation Oncology

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