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  1. Giant cell tumors are rare neoplasms, representing less than 5% of all bone tumors. The vast majority of giant cell tumors occurs in extremity sites and is treated by surgery alone. However, a small percentage...

    Authors: Falk Roeder, Carmen Timke, Felix Zwicker, Christian Thieke, Marc Bischof, Jürgen Debus and Peter E Huber

    Citation: Radiation Oncology 2010 5:18

    Content type: Research

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  2. To compare target dose distribution, comformality, normal tissue avoidance, and irradiated body volume (IBV) in 3DCRT using classic anatomical landmarks (c3DCRT), 3DCRT fitting the PTV (f3DCRT), and intensity-...

    Authors: Leire Arbea, Luis Isaac Ramos, Rafael Martínez-Monge, Marta Moreno and Javier Aristu

    Citation: Radiation Oncology 2010 5:17

    Content type: Methodology

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  3. The purpose of this pilot study was to detect a correlation between serum cytokine levels and severity of mucositis, necessitating installation of a percutaneous endoscopic gastrostomy tube (PEG) in head and n...

    Authors: Amichay Meirovitz, Michal Kuten, Salem Billan, Roxolyana Abdah-Bortnyak, Anat Sharon, Tamar Peretz, Mordechai Sela, Moshe Schaffer and Vivian Barak

    Citation: Radiation Oncology 2010 5:16

    Content type: Research

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  4. In recent years data from both mouse models and human tumors suggest that loss of one allele of genes involved in DNA repair pathways may play a central role in genomic instability and carcinogenesis. Addition...

    Authors: Fengtao Su, Lubomir B Smilenov, Thomas Ludwig, Libin Zhou, Jiayun Zhu, Guangming Zhou and Eric J Hall

    Citation: Radiation Oncology 2010 5:15

    Content type: Research

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  5. To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc® (RA) technology.

    Authors: Antonella Richetti, Antonella Fogliata, Alessandro Clivio, Giorgia Nicolini, Gianfranco Pesce, Emanuela Salati, Eugenio Vanetti and Luca Cozzi

    Citation: Radiation Oncology 2010 5:14

    Content type: Research

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  6. To determine the outcome of patients with brain metastasis (BM) from lung cancer treated with an external beam radiotherapy boost (RTB) after whole brain radiotherapy (WBRT).

    Authors: Nathalie Casanova, Zohra Mazouni, Sabine Bieri, Christophe Combescure, Alessia Pica and Damien C Weber

    Citation: Radiation Oncology 2010 5:13

    Content type: Research

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  7. Three-dimensional conformal radiation therapy (3DCRT)/intensity-modulated radiation therapy (IMRT) combined with or without transcatheter arterial chemoembolization (TACE) for locally advanced hepatocellular c...

    Authors: Jian-Dong Zhao, Jin Liu, Zhi-Gang Ren, Ke Gu, Zhen-Hua Zhou, Wen-Tao Li, Zhen Chen, Zhi-Yong Xu, Lu-Ming Liu and Guo-Liang Jiang

    Citation: Radiation Oncology 2010 5:12

    Content type: Study protocol

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  8. Instable and painful vertebral metastases in patients with progressive visceral metastases present a common therapeutic dilemma. We developed a novel approach to deliver intraoperative radiotherapy (IORT) duri...

    Authors: Frederik Wenz, Frank Schneider, Christian Neumaier, Uta Kraus-Tiefenbacher, Tina Reis, René Schmidt and Udo Obertacke

    Citation: Radiation Oncology 2010 5:11

    Content type: Methodology

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  9. FDG-PET/CT imaging has an emerging role in staging and treatment planning of various tumor locations and a number of literature studies show that also the carcinoma of the anal canal may benefit from this diag...

    Authors: Marco Krengli, Maria E Milia, Lucia Turri, Eleonora Mones, Maria C Bassi, Barbara Cannillo, Letizia Deantonio, Gianmauro Sacchetti, Marco Brambilla and Eugenio Inglese

    Citation: Radiation Oncology 2010 5:10

    Content type: Research

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  10. A fourteen years-old boy was treated post-operatively with proton therapy for a recurrent low-grade oligodendroglioma located in the tectal region. Six months after the end of irradiation (RT), a new enhancing...

    Authors: Candice Meyzer, Frédéric Dhermain, Denis Ducreux, Jean-Louis Habrand, Pascale Varlet, Christian Sainte-Rose, Christelle Dufour and Jacques Grill

    Citation: Radiation Oncology 2010 5:9

    Content type: Case report

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  11. The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the...

    Authors: Benjamin P Soule, Nicole L Simone, William G DeGraff, Rajani Choudhuri, John A Cook and James B Mitchell

    Citation: Radiation Oncology 2010 5:8

    Content type: Research

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  12. Castleman disease (CD) is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. The etiology of this disorder is unclear, although the...

    Authors: Iris AC de Vries, Marjolein MS van Acht, Thomas BJ Demeyere, Marnix LM Lybeert, Jean-Paul de Zoete and Grard AP Nieuwenhuijzen

    Citation: Radiation Oncology 2010 5:7

    Content type: Case report

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  13. Sublethal doses of whole brain irradiation (WBI) are commonly administered therapeutically and frequently result in late delayed radiation injuries, manifesting as severe and irreversible cognitive impairment....

    Authors: Kenneth A Jenrow, Stephen L Brown, Jianguo Liu, Andrew Kolozsvary, Karen Lapanowski and Jae Ho Kim

    Citation: Radiation Oncology 2010 5:6

    Content type: Research

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  14. FLAIR and T2 weighted MRIs are used based on institutional preference to delineate high grade gliomas and surrounding edema for radiation treatment planning. Although these sequences have inherent physical dif...

    Authors: Bronwyn Stall, Leor Zach, Holly Ning, John Ondos, Barbara Arora, Uma Shankavaram, Robert W Miller, Deborah Citrin and Kevin Camphausen

    Citation: Radiation Oncology 2010 5:5

    Content type: Research

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  15. Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictiv...

    Authors: Elisa Bordón, Luis Alberto Henríquez-Hernández, Pedro C Lara, Ana Ruíz, Beatriz Pinar, Carlos Rodríguez-Gallego and Marta Lloret

    Citation: Radiation Oncology 2010 5:4

    Content type: Short report

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  16. To assess the accuracy of fractionated stereotactic radiotherapy (FSRT) using a stereotactic mask fixation system.

    Authors: Giuseppe Minniti, Maurizio Valeriani, Enrico Clarke, Marco D'Arienzo, Michelangelo Ciotti, Roberto Montagnoli, Francesca Saporetti and Riccardo Maurizi Enrici

    Citation: Radiation Oncology 2010 5:1

    Content type: Methodology

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  17. The spine is the most common site for bone metastases. Radiation therapy is a common treatment for palliation of pain and for prevention or treatment of spinal cord compression. Helical tomotherapy (HT), a new...

    Authors: Pei-Wei Shueng, Shih-Chiang Lin, Hou-Tai Chang, Ngot-Swan Chong, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2009 4:71

    Content type: Case report

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  18. Accurate localisation of the lumpectomy cavity (LC) volume is one of the most critical points in 3D-conformal Partial breast irradiation (3D-APBI) treatment planning because the irradiated volume is restricted...

    Authors: Maia Dzhugashvili, Elodie Tournay, Charlotte Pichenot, Ariane Dunant, Eduardo Pessoa, Adel Khallel, Sébastien Gouy, Catherine Uzan, Jean-Rémy Garbay, Françoise Rimareix, Marc Spielmann, Philippe Vielh, Hugo Marsiglia and Céline Bourgier

    Citation: Radiation Oncology 2009 4:70

    Content type: Research

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  19. Glioblastoma multiforme (GBM) is resistant to current cytotoxic therapies, in part because of enhanced DNA repair. Activation of the receptor tyrosine kinase c-Met has been shown to protect cancer cells from D...

    Authors: James W Welsh, Daruka Mahadevan, Ron Ellsworth, Laurence Cooke, David Bearss and Baldassarre Stea

    Citation: Radiation Oncology 2009 4:69

    Content type: Research

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  20. To evaluate clinical outcome after preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy and adjuvant chemotherapy for pathological stage UICC ≥...

    Authors: Matthias Guckenberger, Joern Wulf, Andreas Thalheimer, Daniel Wehner, Arnulf Thiede, Gottfried Müller, Marco Sailer and Michael Flentje

    Citation: Radiation Oncology 2009 4:67

    Content type: Research

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  21. We have previously shown that small molecule PDGF receptor tyrosine kinase inhibitors (RTKI) can drastically attenuate radiation-induced pulmonary fibrosis if the drug administration starts at the time of radi...

    Authors: Minglun Li, Amir Abdollahi, Hermann-Josef Gröne, Kenneth E Lipson, Claus Belka and Peter E Huber

    Citation: Radiation Oncology 2009 4:66

    Content type: Research

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  22. We regret to report that a proofreading error caused an incorrect legend and description of the contents of table 6 to appear in our original publication of this work. The correct description of table 6 is: Un...

    Authors: Jarad M Martin, Andrew Bayley, Robert Bristow, Peter Chung, Mary Gospodarowicz, Cynthia Menard, Michael Milosevic, Tara Rosewall, Padraig R Warde and Charles N Catton

    Citation: Radiation Oncology 2009 4:65

    Content type: Erratum

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    The original article was published in Radiation Oncology 2009 4:50

  23. Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify...

    Authors: Yusei Fujita, Itsuro Kato, Soichi Iwai, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi and Yoshiaki Yura

    Citation: Radiation Oncology 2009 4:63

    Content type: Research

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  24. To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer.

    Authors: Chen-Hsi Hsieh, Ming-Chow Wei, Hsing-Yi Lee, Sheng-Mou Hsiao, Chien-An Chen, Li-Ying Wang, Yen-Ping Hsieh, Tung-Hu Tsai, Yu-Jen Chen and Pei-Wei Shueng

    Citation: Radiation Oncology 2009 4:62

    Content type: Research

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  25. In locally advanced rectal cancer, 5-Fluorouracil (5-FU)-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties...

    Authors: Adalsteinn Gunnlaugsson, Per Nilsson, Elisabeth Kjellén and Anders Johnsson

    Citation: Radiation Oncology 2009 4:61

    Content type: Research

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  26. Primary orbital lymphoma is a rare disease that accounts for 10% of all orbital tumors. Radiotherapy on the orbital cavity is the treatment of choice for this unusual presentation of localized non-Hodgkin's ly...

    Authors: Luigi De Cicco, Laura Cella, Raffaele Liuzzi, Raffaele Solla, Antonio Farella, Giorgio Punzo, Fausto Tranfa, Diego Strianese, Manuel Conson, Giulio Bonavolontà, Marco Salvatore and Roberto Pacelli

    Citation: Radiation Oncology 2009 4:60

    Content type: Research

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  27. The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understa...

    Authors: Ji-Yoon Kim, Yeon-Sil Kim, Young-Kyoon Kim, Hyun-Jin Park, Seung-Joon Kim, Jin-Hyoung Kang, Young-Pil Wang, Hong-Seok Jang, Sang-Nam Lee and Sei-Chul Yoon

    Citation: Radiation Oncology 2009 4:59

    Content type: Research

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  28. Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation is a limiting factor for treatment success. Determination of lymphocyte radiosensitivity by radio-induced apoptosis aris...

    Authors: Elisa Bordón, Luis Alberto Henríquez Hernández, Pedro C Lara, Beatriz Pinar, Fausto Fontes, Carlos Rodríguez Gallego and Marta Lloret

    Citation: Radiation Oncology 2009 4:58

    Content type: Research

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  29. Biological brain tumor imaging using O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET combined with inverse treatment planning for locally restricted dose escalation in patients with glioblastoma multiforme seems to b...

    Authors: Marc D Piroth, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Cengiz Demirel, Charbel Attieh, Hans J Kaiser, Karl J Langen and Michael J Eble

    Citation: Radiation Oncology 2009 4:57

    Content type: Research

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  30. The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful to improve target volume delineatio...

    Authors: Barbara Gehler, Frank Paulsen, Mehmet Ö Öksüz, Till-Karsten Hauser, Susanne M Eschmann, Roland Bares, Christina Pfannenberg, Michael Bamberg, Peter Bartenstein, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2009 4:56

    Content type: Research

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  31. Reirradiation to the abdomen could potentially play a role in palliation of symptoms or local control in patients with gastrointestinal malignancies. Our goal was to retrospectively determine rates of toxicity...

    Authors: Waqar Haque, Christopher H Crane, Sunil Krishnan, Marc E Delclos, Milind Javle, Christopher R Garrett, Robert A Wolff and Prajnan Das

    Citation: Radiation Oncology 2009 4:55

    Content type: Short report

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  32. In the present work we compared the spatial uncertainties associated with a MR-based workflow for external radiotherapy of prostate cancer to a standard CT-based workflow. The MR-based workflow relies on targe...

    Authors: Tufve Nyholm, Morgan Nyberg, Magnus G Karlsson and Mikael Karlsson

    Citation: Radiation Oncology 2009 4:54

    Content type: Research

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  33. To evaluate the functionality of the auditory system in patients who underwent radiotherapy and chemotherapy treatment with cisplatin to treat head and neck tumors.

    Authors: Ana Helena B Dell'Aringa, Myrian L Isaac, Gustavo V Arruda, Maria Carolina BN Esteves, Alfredo Rafael Dell'Aringa, José Luis S Júnior and Alexandre F Rodrigues

    Citation: Radiation Oncology 2009 4:53

    Content type: Review

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  34. To investigate the association between dose to various anatomical structures and dysphagia among patients with head and neck cancer treated by definitive intensity-modulated radiotherapy (IMRT) and concurrent ...

    Authors: Baoqing Li, Dan Li, Derick H Lau, D Gregory Farwell, Quang Luu, David M Rocke, Kathleen Newman, Jean Courquin, James A Purdy and Allen M Chen

    Citation: Radiation Oncology 2009 4:52

    Content type: Research

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  35. Prostate radiotherapy (RT) dose escalation has been reported to result in improved biochemical control at the cost of greater late toxicity. We report on the application of 79.8 Gy in 42 fractions of prostate ...

    Authors: Jarad M Martin, Andrew Bayley, Robert Bristow, Peter Chung, Mary Gospodarowicz, Cynthia Menard, Michael Milosevic, Tara Rosewall, Padraig R Warde and Charles N Catton

    Citation: Radiation Oncology 2009 4:50

    Content type: Research

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    The Erratum to this article has been published in Radiation Oncology 2009 4:65

  36. The combination of ionizing radiation with the pro-apoptotic TRAIL receptor antibody lexatumumab has been shown to exert considerable synergistic apoptotic effects in vitro and in short term growth delay assay...

    Authors: Patrizia Marini, Dorothea Junginger, Stefan Stickl, Wilfried Budach, Maximilian Niyazi and Claus Belka

    Citation: Radiation Oncology 2009 4:49

    Content type: Research

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  37. Radiotherapy (RT) volumes for anal cancer are large and of moderate complexity when organs at risk (OAR) such as testis, small bowel and bladder are at least partially to be shielded. Volumetric intensity modu...

    Authors: Florian Stieler, Dirk Wolff, Frank Lohr, Volker Steil, Yasser Abo-Madyan, Friedlieb Lorenz, Frederik Wenz and Sabine Mai

    Citation: Radiation Oncology 2009 4:48

    Content type: Research

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  38. Gossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enh...

    Authors: Shuraila F Zerp, Rianne Stoter, Gitta Kuipers, Dajun Yang, Marc E Lippman, Wim J van Blitterswijk, Harry Bartelink, Rogier Rooswinkel, Vincent Lafleur and Marcel Verheij

    Citation: Radiation Oncology 2009 4:47

    Content type: Research

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  39. Alkylphosphocholines represent promising antineoplastic drugs that induce cell death in tumor cells by primary interaction with the cell membrane. Recently we could show that a combination of radiotherapy with...

    Authors: Guido Henke, Lars H Lindner, Michael Vogeser, Hans-Jörg Eibl, Jürgen Wörner, Arndt C Müller, Michael Bamberg, Kirsten Wachholz, Claus Belka and Verena Jendrossek

    Citation: Radiation Oncology 2009 4:46

    Content type: Research

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  40. High grade gliomas (HGG) are typically treated with a combination of surgery, radiotherapy and chemotherapy. Three dimensional (3D) conformal radiotherapy treatment planning is still the main stay of treatment...

    Authors: Leor Zach, Bronwyn Stall, Holly Ning, John Ondos, Barbara Arora, Shankavaram Uma, Robert W Miller, Deborah Citrin and Kevin Camphausen

    Citation: Radiation Oncology 2009 4:45

    Content type: Research

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  41. Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal, but frequently at a cost of treatment rel...

    Authors: Giuseppe Minniti, Maurizio Amichetti and Riccardo Maurizi Enrici

    Citation: Radiation Oncology 2009 4:42

    Content type: Review

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  42. Programmed cell death (PCD) is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD). Bcl-2, a c...

    Authors: Andrea Deerberg, Justyna Sosna, Lutz Thon, Claus Belka and Dieter Adam

    Citation: Radiation Oncology 2009 4:41

    Content type: Research

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  43. The availability of alternative sources of information, e. g. the internet, may influence the quantity and quality of information cancer patients receive regarding their disease and treatment. The purpose of t...

    Authors: Johannes Adler, Yvonne Paelecke-Habermann, Patrick Jahn, Margarete Landenberger, Bernd Leplow and Dirk Vordermark

    Citation: Radiation Oncology 2009 4:40

    Content type: Research

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