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  1. We propose a planning method to design true 4-dimensional (4D) intensity-modulated radiotherapy (IMRT) plans, called the t4Dplan method, in which the planning target volume (PTV) of the individual phases of th...

    Authors: Xiaoqiang Li, Xiaochun Wang, Yupeng Li and Xiaodong Zhang
    Citation: Radiation Oncology 2011 6:83
  2. Preoperative radiotherapy and chemotherapy in patients with head and neck cancer result in changes to the vessels that are used to construct microsurgical anastomoses. The aim of the study was to investigate q...

    Authors: Frank Tavassol, Horst Kokemüller, Rüdiger Zimmerer, Nils-Claudius Gellrich and André Eckardt
    Citation: Radiation Oncology 2011 6:81
  3. Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemic chemotherapy and/or radiotherapy. Recent studies of patients with limited metastases treated with curative-intent...

    Authors: Praveena Cheruvu, Su K Metcalfe, Justin Metcalfe, Yuhchyau Chen, Paul Okunieff and Michael T Milano
    Citation: Radiation Oncology 2011 6:80
  4. To assess treatment toxicity and patients' survival/quality of life (QoL) after volumetric modulated arc therapy (VMAT) with simultaneous in-field boost (SIB) for cancer patients with 1 - 4 brain metastases (B...

    Authors: Damien C Weber, Francesca Caparrotti, Mohamed Laouiti and Karim Malek
    Citation: Radiation Oncology 2011 6:79
  5. Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy (RT). The optimal respiratory phase for beam-on may be assessed with a res...

    Authors: Nicolas Peguret, Jacqueline Vock, Vincent Vinh-Hung, Pascal Fenoglietto, David Azria, Habib Zaidi, Michael Wissmeyer, Osman Ratib and Raymond Miralbell
    Citation: Radiation Oncology 2011 6:78
  6. The first-line treatment of a pelvic recurrence in a previously irradiated area is surgery. Unfortunately, few patients are deemed operable, often due to the location of the recurrence, usually too close to th...

    Authors: Sylvain Dewas, Jean Emmanuel Bibault, Xavier Mirabel, Philippe Nickers, Bernard Castelain, Thomas Lacornerie, Hajer Jarraya and Eric Lartigau
    Citation: Radiation Oncology 2011 6:77
  7. To compare the RapidArc plan for primary hepatocellular carcinoma (HCC) with 3-D conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) plans using dosimetric analysis.

    Authors: Yu-Cheng Kuo, Ying-Ming Chiu, Wen-Pin Shih, Hsiao-Wei Yu, Chia-Wen Chen, Pei-Fong Wong, Wei-Chan Lin and Jeng-Jong Hwang
    Citation: Radiation Oncology 2011 6:76
  8. To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer.

    Authors: Chen-Hsi Hsieh, Shiu-Dong Chung, Pei-Hui Chan, Siu-Kai Lai, Hsiao-Chun Chang, Chi-Huang Hsiao, Le-Jung Wu, Ngot-Swan Chong, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh and Pei-Wei Shueng
    Citation: Radiation Oncology 2011 6:75
  9. Salivary gland function decreases after radiation doses of 39 Gy or higher. Currently, submandibular glands are not routinely spared. We implemented a technique for sparing contralateral submandibular glands (...

    Authors: Patricia Doornaert, Wilko FAR Verbakel, Derek HF Rietveld, Ben J Slotman and Suresh Senan
    Citation: Radiation Oncology 2011 6:74
  10. In recent years, there has been a considerable research effort concerning the integration of magnetic resonance imaging (MRI) into the external radiotherapy workflow motivated by the superior soft tissue contr...

    Authors: Joakim H Jonsson, Patrik Brynolfsson, Anders Garpebring, Mikael Karlsson, Karin Söderström and Tufve Nyholm
    Citation: Radiation Oncology 2011 6:73
  11. Stem-like tumor cells are regarded as highly resistant to ionizing radiation (IR). Previous studies have focused on apoptosis early after irradiation, and the apoptosis resistance observed has been attributed ...

    Authors: Elke Firat, Simone Gaedicke, Chizuko Tsurumi, Norbert Esser, Astrid Weyerbrock and Gabriele Niedermann
    Citation: Radiation Oncology 2011 6:71
  12. Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer.

    Authors: Uwe Schneider, Marcin Sumila, Judith Robotka, Günther Gruber, Andreas Mack and Jürgen Besserer
    Citation: Radiation Oncology 2011 6:67
  13. The combined treatment modality of ionizing radiation (IR) with inhibitors of angiogenesis (IoA) is a promising treatment modality based on preclinical in vivo studies using heterotopic xeno- and allograft tumor ...

    Authors: Oliver Riesterer, Christoph Oehler-Jänne, Wolfram Jochum, Angela Broggini-Tenzer, Van Vuong and Martin Pruschy
    Citation: Radiation Oncology 2011 6:66
  14. In modern cancer medicine, morphological magnetic resonance imaging (MRI) is routinely used in diagnostics, treatment planning and assessment of therapeutic efficacy. During the past decade, functional imaging...

    Authors: Kathrine Røe, Manish Kakar, Therese Seierstad, Anne H Ree and Dag R Olsen
    Citation: Radiation Oncology 2011 6:65
  15. Various types of radiation effects in mammalian cells have been studied with the aim to predict the radiosensitivity of tumours and normal tissues, e.g. DNA double strand breaks (DSB), chromosome aberrations a...

    Authors: Nicolaas AP Franken, Rosemarie ten Cate, Przemek M Krawczyk, Jan Stap, Jaap Haveman, Jacob Aten and Gerrit W Barendsen
    Citation: Radiation Oncology 2011 6:64
  16. A strong dose-volume relationship exists between the amount of small bowel receiving low- to intermediate-doses of radiation and the rates of acute, severe gastrointestinal toxicity, principally diarrhea. Ther...

    Authors: Henry Mok, Christopher H Crane, Matthew B Palmer, Tina M Briere, Sam Beddar, Marc E Delclos, Sunil Krishnan and Prajnan Das
    Citation: Radiation Oncology 2011 6:63
  17. Different radiation-techniques in treating local staged prostate cancer differ in their dose- distribution. Physical phantom measurements indicate that for 3D, less healthy tissue is exposed to a relatively hi...

    Authors: Felix Zwicker, Benedict Swartman, Florian Sterzing, Gerald Major, Klaus-Josef Weber, Peter E Huber, Christian Thieke, Jürgen Debus and Klaus Herfarth
    Citation: Radiation Oncology 2011 6:62
  18. Biological models are used to relate the outcome of radiation therapy to dose distribution. As use of biological models in treatment planning expands, uncertainties associated with the use of specific models f...

    Authors: Vitali Moiseenko, William Y Song, Loren K Mell and Niranjan Bhandare
    Citation: Radiation Oncology 2011 6:61
  19. Either higher levels of initial DNA damage or lower levels of radiation-induced apoptosis in peripheral blood lymphocytes have been associated to increased risk for develop late radiation-induced toxicity. It ...

    Authors: Luis Alberto Henríquez-Hernández, Ruth Carmona-Vigo, Beatriz Pinar, Elisa Bordón, Marta Lloret, María Isabel Núñez, Carlos Rodríguez-Gallego and Pedro C Lara
    Citation: Radiation Oncology 2011 6:60
  20. Radiotherapy and radiology have been indispensable components in cancer care for many years. The detection limit of small tumor foci as well as the development of radio-resistance and severe side effects towar...

    Authors: Thomas Efferth and Peter Langguth
    Citation: Radiation Oncology 2011 6:59
  21. Hearing loss is common following chemoradiotherapy for children with medulloblastoma. Compared to photons, proton radiotherapy reduces radiation dose to the cochlea for these patients. Here we examine whether ...

    Authors: Benjamin J Moeller, Murali Chintagumpala, Jimmy J Philip, David R Grosshans, Mary F McAleer, Shiao Y Woo, Paul W Gidley, Tribhawan S Vats and Anita Mahajan
    Citation: Radiation Oncology 2011 6:58
  22. This work aimed to investigate the effect of costunolide, a sesquiterpene lactone isolated from Michelia compressa, on cell cycle distribution and radiosensitivity of human hepatocellular carcinoma (HCC) cells.

    Authors: Chia-Yuan Liu, Hsun-Shuo Chang, Ih-Sheng Chen, Chih-Jen Chen, Ming-Ling Hsu, Shu-Ling Fu and Yu-Jen Chen
    Citation: Radiation Oncology 2011 6:56
  23. Since the 1980s major advances in surgery, radiotherapy and chemotherapy have established multimodal approaches as curative treatment options for oesophageal cancer. In addition the introduction of functional ...

    Authors: Maria C Wolf, Michael Stahl, Bernd J Krause, Luigi Bonavina, Christiane Bruns, Claus Belka and Franz Zehentmayr
    Citation: Radiation Oncology 2011 6:55
  24. To establish recurrence patterns among locally advanced head and neck non-nasopharyngeal squamous cell carcinoma (HNSCC) patients treated with radical (chemo-) radiotherapy and to correlate the sites of loco-r...

    Authors: Didem C Oksuz, Robin J Prestwich, Brendan Carey, Stuart Wilson, Mustafa S Senocak, Ananya Choudhury, Karen Dyker, Catherine Coyle and Mehmet Sen
    Citation: Radiation Oncology 2011 6:54
  25. To evaluate prognostic factors that may influence local control (LC) of T1N0 glottic cancer treated by primary radiotherapy (RT) with 6 MV photons.

    Authors: Chi-Chung Tong, Kwok-Hung Au, Roger KC Ngan, Sin-Ming Chow, Foon-Yiu Cheung, Yiu-Tung Fu, Joseph SK Au and Stephen CK Law
    Citation: Radiation Oncology 2011 6:53
  26. To evaluate the palliative role of radiotherapy (RT) and define the effectiveness of chemotherapy combined with palliative RT (CCRT) in patients with a symptomatic pelvic mass of metastatic colorectal cancer.

    Authors: Sun Hyun Bae, Won Park, Doo Ho Choi, Heerim Nam, Won Ki Kang, Young Suk Park, Joon Oh Park, Ho Kyung Chun, Woo Yong Lee, Seong Hyeon Yun and Hee Cheol Kim
    Citation: Radiation Oncology 2011 6:52
  27. To assess the clinical outcome of chemoradiotherapy with or without surgery for locally recurrent rectal cancer (LRRC) and to find useful and significant prognostic factors for a clinical situation.

    Authors: Joo Ho Lee, Dae Yong Kim, Sun Young Kim, Ji Won Park, Hyo Seong Choi, Jae Hwan Oh, Hee Jin Chang, Tae Hyun Kim and Suk Won Park
    Citation: Radiation Oncology 2011 6:51
  28. Although preoperative radiotherapy (RT) is widely used as the initial treatment for locally advanced rectal cancer (RC) in the neoadjuvant setting, factors determining clinical response have not been adequatel...

    Authors: Koji Yasuda, Takako Nirei, Eiji Sunami, Hirokazu Nagawa and Joji Kitayama
    Citation: Radiation Oncology 2011 6:49
  29. to investigate the factors affecting survival and toxicity in patients treated with stereotactic radiosurgery (SRS), with special attention to volumes of brain receiving a specific dose (V10 - V16 Gy) as predi...

    Authors: Giuseppe Minniti, Enrico Clarke, Gaetano Lanzetta, Mattia Falchetto Osti, Guido Trasimeni, Alessandro Bozzao, Andrea Romano and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2011 6:48
  30. Radiation enteritis is a significant complication of external beam radiotherapy (EBRT) to the pelvis, particularly in patients having high dose radiotherapy (>80 Gy) and in those with a low pelvic peritoneal r...

    Authors: Gary D McKay, Karen Wong and Daniel R Kozman
    Citation: Radiation Oncology 2011 6:47
  31. At present there is no consensus on irradiation treatment volumes for intermediate to high-risk primary cancers or recurrent disease. Conventional imaging modalities, such as CT, MRI and transrectal ultrasound...

    Authors: Florian Würschmidt, Cordula Petersen, Andreas Wahl, Jörg Dahle and Matthias Kretschmer
    Citation: Radiation Oncology 2011 6:44
  32. To assess the value of diffusion weighted imaging (DWI) as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction 192Ir-high-dose-rate brachytherapy (HD...

    Authors: Christian Wybranski, Martin Zeile, David Löwenthal, Frank Fischbach, Maciej Pech, Friedrich-Wilhelm Röhl, Günther Gademann, Jens Ricke and Oliver Dudeck
    Citation: Radiation Oncology 2011 6:43
  33. Gene expression profiling of the transcriptional response of human dermal fibroblasts to in vitro radiation has shown promise as a predictive test of radiosensitivity. This study tested if treatment with the radi...

    Authors: Charlotte B Westbury, Kristine Kleivi Sahlberg, Anne-Lise Borresen-Dale, Clare M Isacke and John R Yarnold
    Citation: Radiation Oncology 2011 6:42
  34. Olfactory Neuroblastoma is a rare malignant tumor of the olfactory tract. Reports in the literature comparing treatment modalities for this tumor are limited.

    Authors: Mary E Platek, Mihai Merzianu, Terry L Mashtare, Saurin R Popat, Nestor R Rigual, Graham W Warren and Anurag K Singh
    Citation: Radiation Oncology 2011 6:41
  35. Hepatic radiation toxicity restricts irradiation of liver malignancies. Better knowledge of hepatic tolerance dose is favourable to gain higher safety and to optimize radiation regimes in radiotherapy of the l...

    Authors: Max Seidensticker, Ricarda Seidensticker, Konrad Mohnike, Christian Wybranski, Thomas Kalinski, Sebastian Luess, Maciej Pech, Peter Wust and Jens Ricke
    Citation: Radiation Oncology 2011 6:40
  36. Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated ...

    Authors: Yuanhong Gao, Hiromichi Ishiyama, Mianen Sun, Kathryn L Brinkman, Xiaozhen Wang, Julie Zhu, Weiyuan Mai, Ying Huang, Daniel Floryk, Michael Ittmann, Timothy C Thompson, E Brian Butler, Bo Xu and Bin S Teh
    Citation: Radiation Oncology 2011 6:39
  37. The purpose of this study is to investigate intra-fraction setup variability in hypo-fractionated cranial and body radiotherapy; this is achieved by means of integrated infrared optical localization and stereo...

    Authors: Maria Francesca Spadea, Barbara Tagaste, Marco Riboldi, Eleonora Preve, Daniela Alterio, Gaia Piperno, Cristina Garibaldi, Roberto Orecchia, Antonio Pedotti and Guido Baroni
    Citation: Radiation Oncology 2011 6:38
  38. In the quest of a curative radiotherapy treatment for gliomas new delivery modes are being explored. At the Biomedical Beamline of the European Synchrotron Radiation Facility (ESRF), a new spatially-fractionat...

    Authors: Silvia Gil, Sukhéna Sarun, Albert Biete, Yolanda Prezado and Manel Sabés
    Citation: Radiation Oncology 2011 6:37
  39. Oxygen deficiency in tumor tissue is associated with a malign phenotype, characterized by high invasiveness, increased metastatic potential and poor prognosis. Hypoxia chambers are the established standard mod...

    Authors: Vasileios Askoxylakis, Gunda Millonig, Ute Wirkner, Christian Schwager, Shoaib Rana, Annette Altmann, Uwe Haberkorn, Jürgen Debus, Sebastian Mueller and Peter E Huber
    Citation: Radiation Oncology 2011 6:35
  40. Melanoma and renal cell carcinoma (RCC) are traditionally considered less radioresponsive than other histologies. Whereas stereotactic body radiation therapy (SBRT) involves radiation dose intensification via ...

    Authors: Michelle A Stinauer, Brian D Kavanagh, Tracey E Schefter, Rene Gonzalez, Thomas Flaig, Karl Lewis, William Robinson, Mark Chidel, Michael Glode and David Raben
    Citation: Radiation Oncology 2011 6:34
  41. In early-phase studies with targeted therapeutics and radiotherapy, it may be difficult to decide whether an adverse event should be considered a dose-limiting toxicity (DLT) of the investigational systemic ag...

    Authors: Åse Bratland, Svein Dueland, Donal Hollywood, Kjersti Flatmark and Anne H Ree
    Citation: Radiation Oncology 2011 6:33

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