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Radiation Physics

Section edited by Christoph Bert and Katia Parodi

The Radiation Physics section aims at providing a platform for medical physics research and applications in radiation oncology. This includes innovative developments in the application of physical sciences to radiation oncology, spanning the broad range of advanced beam delivery and imaging, dosimetry, computation, modeling and data processing. Contributions proposing innovative methodological approaches or presenting original assessment on the clinical relevance of new technologies are welcome. Space is also given to review contributions on timely topics, as well as invited key reviews from renowned experts. Hence, the Radiation Physics section addresses contemporary cutting-edge research and methodological advancements for improved clinical practice, as well as reviews of relevant medical physics issues in radiation oncology, offering a fast review process and broad outreach.

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  1. Using radiobiological modelling to estimate normal tissue toxicity, this study investigates the effects of dose escalation for concurrent chemoradiation therapy (CRT) in lower third oesophageal tumours on the ...

    Authors: Rhys Carrington, John Staffurth, Samantha Warren, Mike Partridge, Chris Hurt, Emiliano Spezi, Sarah Gwynne, Maria A. Hawkins and Thomas Crosby
    Citation: Radiation Oncology 2015 10:236
  2. Treatment plan quality assurance (QA) is important for clinical studies and for institutions aiming to generate near-optimal individualized treatment plans. However, determining how good a given plan is for th...

    Authors: Jim P. Tol, Max Dahele, Alexander R. Delaney, Ben J. Slotman and Wilko F. A. R. Verbakel
    Citation: Radiation Oncology 2015 10:234
  3. Colony formation assay is the gold standard to determine cell reproductive death after treatment with ionizing radiation, applied for different cell lines or in combination with other treatment modalities. Ass...

    Authors: Herbert Braselmann, Agata Michna, Julia Heß and Kristian Unger
    Citation: Radiation Oncology 2015 10:223
  4. To evaluate the performance of a broad scope model-based optimisation process for volumetric modulated arc therapy applied to esophageal cancer.

    Authors: Antonella Fogliata, Giorgia Nicolini, Alessandro Clivio, Eugenio Vanetti, Sarbani Laksar, Angelo Tozzi, Marta Scorsetti and Luca Cozzi
    Citation: Radiation Oncology 2015 10:220
  5. Exploiting biologic imaging, studies have been performed to boost dose to gross intraprostatic tumor volumes (GTV) while reducing dose elsewhere in the prostate. Interest in proton beams has increased due to s...

    Authors: Inhwan Yeo, Prashanth Nookala, Ian Gordon, Reinhard Schulte, Stanley Barnes, Abiel Ghebremedhin, Ning Wang, Gary Yang, Ted Ling, David Bush, Jerry Slater and Baldev Patyal
    Citation: Radiation Oncology 2015 10:213
  6. Modulation factor (MF) and pitch have an impact on Helical TomoTherapy (HT) plan quality and HT users mostly use vendor-recommended settings. This study analyses the effect of these two parameters on both plan...

    Authors: Geert De Kerf, Dirk Van Gestel, Lobke Mommaerts, Danielle Van den Weyngaert and Dirk Verellen
    Citation: Radiation Oncology 2015 10:191
  7. Radiographic image guidance is routinely used for patient positioning in radiotherapy. All radiographic guidance techniques can give a significant radiation dose to the patient. The dose from diagnostic imagin...

    Authors: Uwe Schneider, Roger Hälg and Jürgen Besserer
    Citation: Radiation Oncology 2015 10:188
  8. The purpose of this study was to compare carbon ion radiotherapy (C-ion RT) and stereotactic radiotherapy (SBRT) with photon beams for the treatment of hepatocellular carcinoma (HCC), specifically with regard ...

    Authors: Takanori Abe, Jun-ichi Saitoh, Daijiro Kobayashi, Kei Shibuya, Yoshinori Koyama, Hirohumi Shimada, Katsuyuki Shirai, Tatsuya Ohno and Takashi Nakano
    Citation: Radiation Oncology 2015 10:187
  9. To investigate systematic changes in dose arising when treatment plans optimised using the Anisotropic Analytical Algorithm (AAA) are recalculated using Acuros XB (AXB) in patients treated with definitive chem...

    Authors: Sriram Padmanaban, Samantha Warren, Anthony Walsh, Mike Partridge and Maria A Hawkins
    Citation: Radiation Oncology 2014 9:286
  10. The purpose of this study is to describe a novel brachytherapy technique for lip Squamous Cell Carcinoma, utilizing a customized mold with embedded brachytherapy sleeves, which separates the lip from the mandi...

    Authors: Jon Feldman, Limor Appelbaum, Mordechay Sela, Ninel Voskoboinik, Sarit Kadouri, Jeffrey Weinberger, Itzhak Orion and Amichay Meirovitz
    Citation: Radiation Oncology 2014 9:271
  11. The purpose of the study was to evaluate the feasibility of deformable image registration (DIR) in assessing cumulative dose distributions of the combination of external beam radiotherapy (EBRT) and fractionat...

    Authors: Takanori Abe, Tomoaki Tamaki, Souichi Makino, Takeshi Ebara, Ryuuta Hirai, Kazunori Miyaura, Yu Kumazaki, Tatsuya Ohno, Naoto Shikama, Takashi Nakano and Shingo Kato
    Citation: Radiation Oncology 2014 9:293
  12. The accuracy of dose calculation is crucial to the quality of treatment planning and, consequently, to the dose delivered to patients undergoing radiation therapy. Current general calculation algorithms such a...

    Authors: Yanqun Zhao, Guohai Qi, Gang Yin, Xianliang Wang, Pei Wang, Jian Li, Mingyong Xiao, Jie Li, Shengwei Kang and Xiongfei Liao
    Citation: Radiation Oncology 2014 9:287
  13. In pulsed-dose rate prostate brachytherapy the dose is delivered during 48 hours after implantation, making the treatment sensitive to oedematic effects possibly affecting dose delivery. The aim was to study c...

    Authors: Anna M Dinkla, Bradley R Pieters, Kees Koedooder, Niek van Wieringen, Rob van der Laarse and Arjan Bel
    Citation: Radiation Oncology 2014 9:272
  14. It is expected that physical dose deposition properties render charged particle dose distributions sensitive to targeting uncertainties. Purpose of this work was to investigate the robustness of scanned-beam p...

    Authors: Filippo Ammazzalorso, Urszula Jelen, Rita Engenhart-Cabillic and Wolfgang Schlegel
    Citation: Radiation Oncology 2014 9:279
  15. The aim of this study is to evaluate the ability of transit dosimetry using commercial treatment planning system (TPS) and an electronic portal imaging device (EPID) with simple calibration method to verify th...

    Authors: Tae Seong Baek, Eun Ji Chung, Jaeman Son and Myonggeun Yoon
    Citation: Radiation Oncology 2014 9:273
  16. TomoTherapy (Accuray, USA) has an image-guided radiotherapy system with a megavoltage (MV) X-ray source and an on-board imaging device. This system allows one to acquire the delivery sinogram during the actual...

    Authors: Akihiro Haga, Keiichi Nakagawa, Calvin Maurer, Ken Ruchala, Edward Chao, Dylan Casey, Satoshi Kida, Dousatsu Sakata, Masahiro Nakano, Taiki Magome and Yoshitaka Masutani
    Citation: Radiation Oncology 2014 9:252
  17. There as yet exists no systematic planning study investigating the novel mARC rotational radiotherapy technique, which is conceptually different from VMAT. We therefore present a planning study for prostate ca...

    Authors: Yvonne Dzierma, Katharina Bell, Jan Palm, Frank Nuesken, Norbert Licht and Christian Rübe
    Citation: Radiation Oncology 2014 9:250
  18. In modern radiotherapy, it is crucial to monitor the performance of all linac components including gantry, collimation system and electronic portal imaging device (EPID) during arc deliveries. In this study, a...

    Authors: Pejman Rowshanfarzad, Conor K McGarry, Michael P Barnes, Mahsheed Sabet and Martin A Ebert
    Citation: Radiation Oncology 2014 9:249
  19. To evaluate and compare dosimetric parameters of volumetric modulated arctherapy (VMAT) and helical tomotherapy (HT) for non-anaplastic thyroid cancer adjuvant radiotherapy.

    Authors: Jonathan Khalifa, Laure Vieillevigne, Sabrina Boyrie, Monia Ouali, Thomas Filleron, Michel Rives and Anne Laprie
    Citation: Radiation Oncology 2014 9:247
  20. To precisely calculate skin dose and thus to evaluate the relationship between the skin dose and permanent alopecia for pediatric medulloblastoma patients treated with proton beams.

    Authors: Chul Hee Min, Harald Paganetti, Brian A Winey, Judith Adams, Shannon M MacDonald, Nancy J Tarbell and Torunn I Yock
    Citation: Radiation Oncology 2014 9:220
  21. To moving lung tumors, we applied a respiratory-gated strategy to carbon-ion pencil beam scanning with multiple phase-controlled rescanning (PCR). In this simulation study, we quantitatively evaluated dose dis...

    Authors: Wataru Takahashi, Shinichiro Mori, Mio Nakajima, Naoyoshi Yamamoto, Taku Inaniwa, Takuji Furukawa, Toshiyuki Shirai, Koji Noda, Keiichi Nakagawa and Tadashi Kamada
    Citation: Radiation Oncology 2014 9:238
  22. Glioblastoma multiforme (GBM) frequently recurs at the same location after radiotherapy. Further dose escalation using conventional methods is limited by normal tissue tolerance. 4π non-coplanar radiotherapy h...

    Authors: Dan Nguyen, Jean-Claude M Rwigema, Victoria Y Yu, Tania Kaprealian, Patrick Kupelian, Michael Selch, Percy Lee, Daniel A Low and Ke Sheng
    Citation: Radiation Oncology 2014 9:239
  23. To investigate the feasibility of constant dose rate volumetric modulated arc therapy (CDR-VMAT) in the treatment of nasopharyngeal cancer (NPC) patients and to introduce rotational arc radiotherapy for linacs...

    Authors: Wenliang Yu, Haijiao Shang, Congying Xie, Ce Han, Jinling Yi, Yongqiang Zhou and Xiance Jin
    Citation: Radiation Oncology 2014 9:235
  24. Intensity modulated arc therapy (IMAT) has been widely adopted for Stereotactic Body Radiotherapy (SBRT) for lung cancer. While treatment dose is optimized and calculated on a static Computed Tomography (CT) i...

    Authors: Wei Zou, Lingshu Yin, Jiajian Shen, Michael N Corradetti, Maura Kirk, Reshma Munbodh, Penny Fang, Salma K Jabbour, Charles B Simone, Ning J Yue, Ramesh Rengan and Boon-Keng Kevin Teo
    Citation: Radiation Oncology 2014 9:225
  25. To evaluate in-silico the performance of a model-based optimization process for volumetric modulated arc therapy (RapidArc) applied to hepatocellular cancer treatments.

    Authors: Antonella Fogliata, Po-Ming Wang, Francesca Belosi, Alessandro Clivio, Giorgia Nicolini, Eugenio Vanetti and Luca Cozzi
    Citation: Radiation Oncology 2014 9:236
  26. The aim of current study was to investigate the way dose is prescribed to lung lesions during SBRT using advanced dose calculation algorithms that take into account electron transport (type B algorithms). As t...

    Authors: Thomas Lacornerie, Albert Lisbona, Xavier Mirabel, Eric Lartigau and Nick Reynaert
    Citation: Radiation Oncology 2014 9:223
  27. To study the feasibility and the potential benefits of defining the internal gross tumor volume (IGTV) of hepatocellular carcinoma (HCC) using contrast-enhanced 4D CT images obtained by combining arterial-phas...

    Authors: Hua Xu, Guanzhong Gong, Hong Wei, Lusheng Chen, Jinhu Chen, Jie Lu, Tonghai Liu, Jian Zhu and Yong Yin
    Citation: Radiation Oncology 2014 9:221
  28. To compare the dosimetric differences among fixed field intensity-modulated radiation therapy (IMRT), single-arc volumetric-modulated arc therapy (SA-VMAT) and double-arc volumetric-modulated arc therapy (DA-V...

    Authors: Jun Shang, Wei Kong, Yan-yang Wang, Zhe Ding, Gang Yan and Hong Zhe
    Citation: Radiation Oncology 2014 9:219
  29. Gated Volumetric Modulated Arc Therapy (VMAT) is an emerging radiation therapy modality for treatment of tumors affected by respiratory motion. However, gating significantly prolongs the treatment time, as del...

    Authors: Benjamin Fahimian, Junqing Wu, Huanmei Wu, Sarah Geneser and Lei Xing
    Citation: Radiation Oncology 2014 9:209
  30. Novel irradiation techniques are continuously introduced in radiotherapy to optimize the accuracy, the security and the clinical outcome of treatments. These changes could raise the question of discontinuity i...

    Authors: Abdulhamid Chaikh, Jean-Yves Giraud, Emmanuel Perrin, Jean-Pierre Bresciani and Jacques Balosso
    Citation: Radiation Oncology 2014 9:205
  31. To compare conventional lateral photon-electron, fixed-beam intensity modulated radiation therapy (IMRT), coplanar and non-coplanar RapidArc for the treatment of a diffuse sebaceous gland carcinoma of the scalp.

    Authors: Jiang Hu, WeiWei Xiao, ZhiChun He, DeHua Kang, ALong Chen and ZhenYu Qi
    Citation: Radiation Oncology 2014 9:204
  32. Intensity modulated proton therapy (IMPT) plans are normally generated utilizing multiple field optimization (MFO) techniques. Similar to photon based IMRT, MFO allows for the utilization of a simultaneous int...

    Authors: Xiaorong Ronald Zhu, Falk Poenisch, Heng Li, Xiaodong Zhang, Narayan Sahoo, Richard Y Wu, Xiaoqiang Li, Andrew K Lee, Eric L Chang, Seungtaek Choi, Thomas Pugh, Steven J Frank, Michael T Gillin, Anita Mahajan and David R Grosshans
    Citation: Radiation Oncology 2014 9:202
  33. In this study, dosimetric aspects of TSEI consisting of a 4 MeV beam with no spoiler were investigated in comparison to a nominal 6 MeV beam with spoiler, and the potential for clinical applications was evalua...

    Authors: So-Yeon Park, Beom Seok Ahn, Jong Min Park, Sung-Joon Ye, Il han Kim and Jung-in Kim
    Citation: Radiation Oncology 2014 9:197
  34. To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned.

    Authors: Joep Stroom, Sandra Vieira, Dalila Mateus, Carlo Greco, Antonella Fogliata, Giorgia Nicolini, Alessandro Clivio, Eugenio Vanetti and Luca Cozzi
    Citation: Radiation Oncology 2014 9:196
  35. To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer with regard to the coverage of p...

    Authors: Yuri Jeong, Sang-wook Lee, Jungwon Kwak, Ilsung Cho, Sang Min Yoon, Jong Hoon Kim, Jin-hong Park, Eun Kyung Choi, Si Yeol Song, Young Seok Kim, Su Ssan Kim, Ji Hyeon Joo and Seung Do Ahn
    Citation: Radiation Oncology 2014 9:193
  36. The principal aim of this study was to evaluate the feasibility of incorporating four-dimensional (4D)-computed tomography (CT)-based functional information into treatment planning and to evaluate the potentia...

    Authors: Ruihao Wang, Shuxu Zhang, Hui Yu, Shengqu Lin, Guoqian Zhang, Rijie Tang and Bin Qi
    Citation: Radiation Oncology 2014 9:184
  37. To determine the optimal threshold of 18 F-fluorodexyglucose (18 F-FDG) positron emission tomography CT (PET/CT) images that generates the best volumetric match to internal gross target volume (IGTV) based on fou...

    Authors: Yi-Li Duan, Jian-Bin Li, Ying-Jie Zhang, Wei Wang, Feng-Xiang Li, Xiao-Rong Sun, Yan-Luan Guo and Dong-Ping Shang
    Citation: Radiation Oncology 2014 9:182
  38. To analyse the frequency of re-planning and its variability dependent on the IGRT correction strategy and on the modification of the dosimetric criteria for re-planning for the spinal cord in head and neck IG-...

    Authors: Markus Stoll, Kristina Giske, Jürgen Debus, Rolf Bendl and Eva Maria Stoiber
    Citation: Radiation Oncology 2014 9:175
  39. In radiotherapy treatment planning, intravenous administration of an iodine-based contrast agent during computed tomography (CT) improves the accuracy of delineating target volumes. However, increased tissue a...

    Authors: Sachiko Yamada, Takashi Ueguchi, Toshiyuki Ogata, Hirokazu Mizuno, Ryota Ogihara, Masahiko Koizumi, Takeshi Shimazu, Kenya Murase and Kazuhiko Ogawa
    Citation: Radiation Oncology 2014 9:168
  40. To investigate the sensitivity of various gamma criteria used in the gamma-index method for patient-specific volumetric modulated arc therapy (VMAT) quality assurance (QA) for stereotactic body radiation thera...

    Authors: Jung-in Kim, So-Yeon Park, Hak Jae Kim, Jin Ho Kim, Sung-Joon Ye and Jong Min Park
    Citation: Radiation Oncology 2014 9:167
  41. The newest release of the Eclipse (Varian) treatment planning system (TPS) includes an optimizing engine for Elekta volumetric-modulated arc therapy (VMAT) planning. The purpose of this study was to evaluate t...

    Authors: Samuel Peters, Hans Schiefer and Ludwig Plasswilm
    Citation: Radiation Oncology 2014 9:153
  42. Stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer (NSCLC) has led to promising local control and overall survival for fractionation schemes with increasingly high fractional doses. A point h...

    Authors: Emely Lindblom, Laura Antonovic, Alexandru Dasu, Ingmar Lax, Peter Wersäll and Iuliana Toma-Dasu
    Citation: Radiation Oncology 2014 9:149
  43. To evaluate and compare the risks of secondary cancers from therapeutic doses received by patients with hepatocellular carcinoma (HCC) during intensity-modulated radiotherapy (IMRT), volumetric arc therapy (VM...

    Authors: Dong Wook Kim, Kwangzoo Chung, Weon Kuu Chung, Sun Hyun Bae, Dong Oh Shin, Seongeon Hong, Sung Ho Park, Sung-Yong Park, Chae-Seon Hong, Young Kyung Lim, Dongho Shin, Se Byeong Lee, Hyun-ho Lee, Jiwon Sung and Myonggeun Yoon
    Citation: Radiation Oncology 2014 9:109
  44. To evaluate the volumetric and geometric differences in the ITVs generated by four-dimensional (4D) computed tomography (CT), a modified slow CT scan, and a combination of these CT methods in lung cancer patie...

    Authors: Seong Soon Jang, Gil Ja Huh, Suk Young Park, Po Song Yang, Hae Nam Chung, Jae Hyuk Seo, Ji Chan Park, Young Jun Yang and Eun Youn Cho
    Citation: Radiation Oncology 2014 9:106
  45. According to the latest amendment of the Medical Device Directive standalone software qualifies as a medical device when intended by the manufacturer to be used for medical purposes. In this context, the EN 62...

    Authors: Angelika Höss, Christian Lampe, Ralf Panse, Benjamin Ackermann, Jakob Naumann and Oliver Jäkel
    Citation: Radiation Oncology 2014 9:79

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