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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. In previous experiments an enhanced anti-proliterative effect of the EGFR/ErbB tyrosine kinase inhibitor (TKI) BIBW 2992 with single dose irradiation was observed in FaDu tumour xenografts. Aim of the present ...

    Authors: Kristin Gurtner, Nadja Ebert, Dorothee Pfitzmann, Wolfgang Eicheler, Daniel Zips, Michael Baumann and Mechthild Krause
    Citation: Radiation Oncology 2014 9:261
    Content type: Research Published on:

  2. To evaluate patient selection criteria, methodology, safety and clinical outcomes of stereotactic body radiotherapy (SBRT) for treatment of vertebral metastases.

    Authors: Matthias Guckenberger, Frederick Mantel, Peter C Gerszten, John C Flickinger, Arjun Sahgal, Daniel Létourneau, Inga S Grills, Maha Jawad, Daniel K Fahim, John H Shin, Brian Winey, Jason Sheehan and Ron Kersh
    Citation: Radiation Oncology 2014 9:226
    Content type: Research Published on:

  3. The transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor of mitocho...

    Authors: Linda Helbig, Lydia Koi, Kerstin Brüchner, Kristin Gurtner, Holger Hess-Stumpp, Kerstin Unterschemmann, Michael Baumann, Daniel Zips and Ala Yaromina
    Citation: Radiation Oncology 2014 9:207
    Content type: Research Published on:

  4. Radiation induced bystander effects are an important component of the overall response of cells to irradiation and are associated with human health risks. The mechanism responsible includes intra-cellular and ...

    Authors: Shanaz A Ghandhi, Brian Ponnaiya, Sunil K Panigrahi, Kevin M Hopkins, Qingping Cui, Tom K Hei, Sally A Amundson and Howard B Lieberman
    Citation: Radiation Oncology 2014 9:206
    Content type: Research Published on:

  5. Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been implemented as a standard treatment strategy in locally advanced rectal cancer (LARC). However, there is a wide spectrum of response to nCRT....

    Authors: Xiangjiao Meng, Zhaoqin Huang, Renben Wang, Yuhong Jiao, Huijuan Li, Xiaoqing Xu, Rui Feng, Kunli Zhu, Shumei Jiang, Hongjiang Yan and Jinming Yu
    Citation: Radiation Oncology 2014 9:188
    Content type: Research Published on:

  7. B cell translocation gene 1 (BTG1) has long been recognized as a tumor suppressor gene. Recent reports demonstrated that BTG1 plays an important role in progression of cell cycle and is involved in cellular respo...

    Authors: Xin Wu, Nan Ding, Wentao Hu, Jinpeng He, Shuai Xu, Hailong Pei, Junrui Hua, Guangming Zhou and Jufang Wang
    Citation: Radiation Oncology 2014 9:179
    Content type: Research Published on:

  8. Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The purpose of this study was to assess the possibility of predicting in v...

    Authors: Julie Marill, Naeemunnisa Mohamed Anesary, Ping Zhang, Sonia Vivet, Elsa Borghi, Laurent Levy and Agnes Pottier
    Citation: Radiation Oncology 2014 9:150
    Content type: Research Published on:

  9. The aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injection...

    Authors: Chuan-Chao Li, Jun-Lin Chi, Yu Ma, Jian-Hong Li, Chuan-Qin Xia, Lin Li, Zhuo Chen and Xiao-Li Chen
    Citation: Radiation Oncology 2014 9:144
    Content type: Research Published on:

  10. Exposure to radiation provokes cellular responses, which are likely regulated by gene expression networks. MicroRNAs are small non-coding RNAs, which regulate gene expression by promoting mRNA degradation or i...

    Authors: Ling Xie, Jundong Zhou, Shuyu Zhang, Qing Chen, Rensheng Lai, Weiqun Ding, ChuanJun Song, XingJun Meng and Jinchang Wu
    Citation: Radiation Oncology 2014 9:111
    Content type: Research Published on:

  11. Radiation fibrosis is not easily measurable although clinical scores have been developed for this purpose. Biomarkers present an alternative more objective approach to quantification, and estimation in blood p...

    Authors: Charlotte B Westbury, Joanne Haviland, Sue Davies, Lone Gothard, Bahja Ahmed Abdi, Mark Sydenham, Jo Bowen, Richard Stratton, Susan C Short and John R Yarnold
    Citation: Radiation Oncology 2014 9:103
    Content type: Research Published on:

  12. Lymphocyte infiltration is a common feature of radiation-induced pneumonitis and fibrosis, but their contribution to the pathogenic processes is still unclear. Here, we addressed the impact of thorax irradiati...

    Authors: Florian Wirsdörfer, Federica Cappuccini, Muska Niazman, Simone de Leve, Astrid M Westendorf, Lutz Lüdemann, Martin Stuschke and Verena Jendrossek
    Citation: Radiation Oncology 2014 9:98
    Content type: Research Published on:

  13. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Despite a multimodal therapy consisting of resection followed by fractionated radiotherapy (RT) combined with the chemotherapeuti...

    Authors: Yvonne Rubner, Carolin Muth, Annedore Strnad, Anja Derer, Renate Sieber, Rolf Buslei, Benjamin Frey, Rainer Fietkau and Udo S Gaipl
    Citation: Radiation Oncology 2014 9:89
    Content type: Research Published on:

  14. Radiotherapy, administered in fractionated as well as ablative settings, is an essential treatment component for breast cancer. Besides the direct tumor cell death inducing effects, there is growing evidence t...

    Authors: Roman Hennel, Nikko Brix, Karin Seidl, Anne Ernst, Heike Scheithauer, Claus Belka and Kirsten Lauber
    Citation: Radiation Oncology 2014 9:85
    Content type: Research Published on:

  15. Cervical cancer is the third most common type of cancer in women worldwide and radiotherapy remains its predominant therapeutic treatment. Artesunate (ART), a derivative of artemisinin, has shown radiosensitiz...

    Authors: Judong Luo, Wei Zhu, Yiting Tang, Han Cao, Yuanyuan Zhou, Rong Ji, Xifa Zhou, Zhongkai Lu, Hongying Yang, Shuyu Zhang and Jianping Cao
    Citation: Radiation Oncology 2014 9:84
    Content type: Research Published on:

  16. A discontinuous dose response relationship is a major characteristic of the anti-inflammatory effects of low-dose X-irradiation therapy. Although recent data indicate an involvement of a variety of molecular m...

    Authors: Martin Large, Sebastian Reichert, Stephanie Hehlgans, Claudia Fournier, Claus Rödel and Franz Rödel
    Citation: Radiation Oncology 2014 9:80
    Content type: Research Published on:

  17. Brain radiation necrosis (RN) occurring after radiotherapy is a serious complication. We and others have performed several treatments for RN, using anticoagulants, corticosteroids, surgical resection and bevac...

    Authors: Tomo Miyata, Taichiro Toho, Naosuke Nonoguchi, Motomasa Furuse, Hiroko Kuwabara, Erina Yoritsune, Shinji Kawabata, Toshihiko Kuroiwa and Shin-Ichi Miyatake
    Citation: Radiation Oncology 2014 9:51
    Content type: Research Published on:

  18. The overexpression of histone deacetylase (HDAC) and a subsequent decrease in the acetylation levels of nuclear histones are frequently observed in cancer cells. Generally it was accepted that the deacetylatio...

    Authors: Cheol-Hun Son, Jin-Hee Keum, Kwangmo Yang, Jiho Nam, Mi-Ju Kim, Sun-Hee Kim, Chi-Dug Kang, Sae-Ock Oh, Chi-Dae Kim, You-Soo Park and Jaeho Bae
    Citation: Radiation Oncology 2014 9:49
    Content type: Research Published on:

  19. In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported...

    Authors: Weilian Yang, Rolf F Barth, Tianyao Huo, Robin J Nakkula, Michael Weldon, Nilendu Gupta, Lawrence Agius and John C Grecula
    Citation: Radiation Oncology 2014 9:25
    Content type: Research Published on:

  20. Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost param...

    Authors: Kristian Unger
    Citation: Radiation Oncology 2014 9:21
    Content type: Review Published on:

  21. Radiation-induced alterations in posttranslational histone modifications (PTMs) may affect the cellular response to radiation damage in the DNA. If not reverted appropriately, altered PTM patterns may cause lo...

    Authors: Belinda Maroschik, Anne Gürtler, Anne Krämer, Ute Rößler, Maria Gomolka, Sabine Hornhardt, Simone Mörtl and Anna A Friedl
    Citation: Radiation Oncology 2014 9:15
    Content type: Research Published on:

  22. Innovative strategies in cancer radiotherapy are stimulated by the growing knowledge on cellular and molecular tumor biology, tumor pathophysiology, and tumor microenvironment. In terms of tumor diagnostics an...

    Authors: Clemens C Cyran, Philipp M Paprottka, Michel Eisenblätter, Dirk A Clevert, Carsten Rist, Konstantin Nikolaou, Kirsten Lauber, Frederik Wenz, Daniel Hausmann, Maximilian F Reiser, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2014 9:3
    Content type: Review Published on:

  23. Circulating microRNAs (miRNAs) are easily accessible and have already proven to be useful as prognostic markers in cancer patients. However, their origin and function in the circulation is still under discussi...

    Authors: Isolde Summerer, Maximilian Niyazi, Kristian Unger, Adriana Pitea, Verena Zangen, Julia Hess, Michael J Atkinson, Claus Belka, Simone Moertl and Horst Zitzelsberger
    Citation: Radiation Oncology 2013 8:296
    Content type: Research Published on:

    The Erratum to this article has been published in Radiation Oncology 2015 10:102

  24. Boron neutron capture therapy (BNCT) is a selective radiotherapy that is dependent on the accumulation of 10B compound in tumors. Low-intensity ultrasound produces a transient pore on cell membranes, sonoporation...

    Authors: Naofumi Yamatomo, Takaki Iwagami, Itsuro Kato, Shin-Ichiro Masunaga, Yoshinori Sakurai, Soichi Iwai, Mitsuhiro Nakazawa, Koji Ono and Yoshiaki Yura
    Citation: Radiation Oncology 2013 8:280
    Content type: Research Published on:

  25. Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)...

    Authors: Malene M Clausen, Anders E Hansen, Per Munck af Rosenschold, Andreas Kjær, Annemarie T Kristensen, Fintan J McEvoy and Svend A Engelholm
    Citation: Radiation Oncology 2013 8:262
    Content type: Research Published on:

  27. Although two-dimensional (2-D) monolayer cell cultures provide important information on basic tumor biology and radiobiology, they are not representative of the complexity of three-dimensional (3-D) solid tumo...

    Authors: Anna Tesei, Anna Sarnelli, Chiara Arienti, Enrico Menghi, Laura Medri, Elisa Gabucci, Sara Pignatta, Mirella Falconi, Rosella Silvestrini, Wainer Zoli, Vincenzo D’Errico, Antonino Romeo, Elisabetta Parisi and Rolando Polico
    Citation: Radiation Oncology 2013 8:257
    Content type: Research Published on:

  28. Radiation-induced skin injury remains a serious concern during radiotherapy. Cu/Zn-superoxide dismutase (Cu/Zn-SOD, SOD1) is a conserved enzyme for scavenging superoxide radical in cells. Because of the integrity...

    Authors: Qing Gu, Tienan Feng, Han Cao, Yiting Tang, Xin Ge, Judong Luo, Jiao Xue, Jinyong Wu, Hongying Yang, Shuyu Zhang and Jianping Cao
    Citation: Radiation Oncology 2013 8:253
    Content type: Research Published on:

  29. Most childhood cancer survivors will develop ionizing radiation treatment-related health conditions that, in many instances, resemble age-associated pathologies. Treatment-induced premature senescence could be...

    Authors: Sophie Marcoux, Oanh NL Le, Chloé Langlois-Pelletier, Caroline Laverdière, Afshin Hatami, Philippe Robaey and Christian M Beauséjour
    Citation: Radiation Oncology 2013 8:252
    Content type: Short report Published on:

  30. Brain metastasis from breast cancer poses a major clinical challenge. Integrins play a role in regulating adhesion, growth, motility, and survival, and have been shown to be critical for metastatic growth in t...

    Authors: Tim Lautenschlaeger, James Perry, David Peereboom, Bin Li, Ahmed Ibrahim, Alexander Huebner, Wei Meng, Julia White and Arnab Chakravarti
    Citation: Radiation Oncology 2013 8:246
    Content type: Research Published on:

  31. MicroRNAs are non-coding RNAs involved in the regulation of gene expression including DNA damage responses. Low doses of low energy X-ray radiation, similar to those used in mammographic exams, has been descri...

    Authors: Luiza Stankevicins, Ana Paula Almeida da Silva, Flavia Ventura dos Passos, Evelin dos Santos Ferreira, Maria Cecilia Menks Ribeiro, Mariano G David, Evandro J Pires, Samara Cristina Ferreira-Machado, Yegor Vassetzky, Carlos Eduardo de Almeida and Claudia Vitoria de Moura Gallo
    Citation: Radiation Oncology 2013 8:231
    Content type: Research Published on:

  34. To determine the biological effectiveness of single, fractionated and continuous low dose rate irradiation on the human colorectal cancer cell line CL187 in vitro and explore the cellular mechanisms.

    Authors: Hao Wang, Jinna Li, Ang Qu, Jingjia Liu, Yong Zhao and Junjie Wang
    Citation: Radiation Oncology 2013 8:196
    Content type: Research Published on:

  35. Radioresistance is the common cause for radiotherapy failure in non-small cell lung cancer (NSCLC), and the degree of radiosensitivity of tumor cells is different during different cell cycle phases. The object...

    Authors: Rubo Cao, Qian Ding, Pindong Li, Jun Xue, Zhenwei Zou, Jing Huang and Gang Peng
    Citation: Radiation Oncology 2013 8:178
    Content type: Research Published on:

  36. To evaluate the role of γ-H2AX in peripheral blood lymphocytes (PBLs) as a predictive biomarker of the severity of oral mucositis (OM) in head and neck cancer (HNC) patients with receiving radiotherapy.

    Authors: Ping Li, Cheng-run Du, Wen-cai Xu, Ze-liang Shi, Qing Zhang, Zhao-bin Li and Shen Fu
    Citation: Radiation Oncology 2013 8:155
    Content type: Research Published on:
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Radiation Oncology

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