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Radiation Biology and Molecular Radiation Oncology

Section edited by Kirsten Lauber and Horst Zitzelsberger

The Radiation Biology and Molecular Radiation Oncology section aims at providing a platform for biological research and its translation into clinical radiation oncology. This includes innovative studies on the cellular responses towards ionizing irradiation and their underlying mechanisms, technical approaches, identification of biomarkers, and experimental therapy approaches. Submission of studies involving animal models and/or primary, patient-derived samples/material is particularly encouraged. Space is also provided for review contributions on timely topics, as well as invited key reviews from renowned experts. Thus, the Radiation Biology and Molecular Radiation Oncology section addresses current, timely and cutting-edge research and reviews about biologically relevant issues in radiation oncology, while offering a fast review process and broad outreach.

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  1. Cells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently availab...

    Authors: Olli Metsälä, Joose Kreutzer, Heidi Högel, Petra Miikkulainen, Pasi Kallio and Panu M. Jaakkola
    Citation: Radiation Oncology 2018 13:220
  2. HOTAIR was known to enhance radioresistance in several cancers. However, the function of HOTAIR on radioresistance involving the regulation of HIF-1α in cervical cancer has not been reported.

    Authors: Ning Li, Dan-dan Meng, Ling Gao, Yue Xu, Pei-jie Liu, Yong-wei Tian, Zhen-ying Yi, Yan Zhang, Xiao-jing Tie and Zhi-qiao Xu
    Citation: Radiation Oncology 2018 13:210
  3. Concomitant chemo-radiotherapy is the reference treatment for non-resectable locally-advanced Non-Small Cell Lung Cancer (NSCLC). Increasing radiotherapy total dose in the whole tumour volume has been shown to...

    Authors: Sébastien Thureau, Bernard Dubray, Romain Modzelewski, Pierre Bohn, Sébastien Hapdey, Sabine Vincent, Elodie Anger, David Gensanne, Nicolas Pirault, Gouel Pierrick and Pierre Vera
    Citation: Radiation Oncology 2018 13:208
  4. Radiation therapy is an indispensable part of various treatment modalities for breast cancer. Specifically, for non-inflammatory locally advanced breast cancer (LABC) patients, preoperative radiotherapy (pRT) ...

    Authors: Miljana Tanić, Ana Krivokuća, Milena Čavić, Jasmina Mladenović, Vesna Plesinac Karapandžić, Stephan Beck, Siniša Radulović, Snezana Susnjar and Radmila Janković
    Citation: Radiation Oncology 2018 13:193
  5. Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular per...

    Authors: Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, Laura Marucci, Filomena Spasiano, Irene Terrenato and Giuseppe Sanguineti
    Citation: Radiation Oncology 2018 13:189
  6. Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-i...

    Authors: Yue Zhou, Xiaowu Sheng, Feiyan Deng, Hui Wang, Liangfang Shen, Yong Zeng, Qianxi Ni, Shibin Zhan and Xiao Zhou
    Citation: Radiation Oncology 2018 13:160
  7. Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways.

    Authors: Dasantha Jayamanne, Helen Wheeler, David Brazier, Allison Newey, Marina Kastelan, Linxin Guo and Michael Back
    Citation: Radiation Oncology 2018 13:133
  8. Brain metastasis is becoming increasingly prevalent in breast cancer due to improved extra-cranial disease control. With emerging availability of modern image-guided radiation platforms, mouse models of brain ...

    Authors: Niloufar Zarghami, Donna H. Murrell, Michael D. Jensen, Frederick A. Dick, Ann F. Chambers, Paula J. Foster and Eugene Wong
    Citation: Radiation Oncology 2018 13:104
  9. Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administratio...

    Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue and G. Hildebrandt
    Citation: Radiation Oncology 2018 13:89
  10. The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity of the disease and the lack of randomi...

    Authors: Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Tae Gyu Kim and Jin Ho Song
    Citation: Radiation Oncology 2018 13:85
  11. Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235...

    Authors: Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti and Antonio Daga
    Citation: Radiation Oncology 2018 13:76
  12. The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radi...

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe and Keiichi Nakagawa
    Citation: Radiation Oncology 2018 13:70
  13. The incomplete repair (IR) model expresses the cell repair effect from radiation-induced damage over time, which is given little consideration in actual treatment planning. By incorporating the IR model into t...

    Authors: Yushi Wakisaka, Masashi Yagi, Iori Sumida, Masaaki Takashina, Kazuhiko Ogawa and Masahiko Koizumi
    Citation: Radiation Oncology 2018 13:30
  14. The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foun...

    Authors: Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus and Christian P. Karger
    Citation: Radiation Oncology 2018 13:5
  15. As there is a growing number of long-term cancer survivors, the incidence of carcinogenesis as a late effect of radiotherapy is getting more and more into the focus. The risk for the development of secondary m...

    Authors: Dajana Juerß, Monique Zwar, Ulrich Giesen, Ralf Nolte, Stephan Kriesen, Giorgio Baiocco, Monika Puchalska, Marc-Jan van Goethem, Katrin Manda and Guido Hildebrandt
    Citation: Radiation Oncology 2017 12:159
  16. Radiotherapy plays a major role in the management of high grade glioma. However, the radioresistance of glioma cells limits its efficiency and drives recurrence inside the irradiated tumor volume leading to po...

    Authors: Julian Biau, Emmanuel Chautard, Leanne De Koning, Frank Court, Bruno Pereira, Pierre Verrelle and Marie Dutreix
    Citation: Radiation Oncology 2017 12:123
  17. Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    Authors: P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné
    Citation: Radiation Oncology 2017 12:120
  18. Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Authors: Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto
    Citation: Radiation Oncology 2017 12:111
  19. Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-sur...

    Authors: Shing Yau Tam, Vincent Wing Cheung Wu and Helen Ka Wai Law
    Citation: Radiation Oncology 2017 12:57
  20. Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Authors: Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake
    Citation: Radiation Oncology 2017 12:26
  21. In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Authors: Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki
    Citation: Radiation Oncology 2016 11:153
  22. Hadron therapy is an innovative technique where cancer cells are precisely killed leaving surrounding healthy cells least affected by high linear energy transfer (LET) radiation like carbon ion beam. Anti-meta...

    Authors: Atanu Ghorai, Asitikantha Sarma, Priyanka Chowdhury and Utpal Ghosh
    Citation: Radiation Oncology 2016 11:126
  23. Intracavitary irradiation plays a pivotal role in definitive radiotherapy for cervical cancer, and the Ir-192 high dose-rate remote afterloading system (HDR-RALS) is often used for this purpose. Under this con...

    Authors: Taito Asahina, Atsushi Kaida, Tatsuaki Goto, Ryo-Ichi Yoshimura, Keisuke Sasai and Masahiko Miura
    Citation: Radiation Oncology 2016 11:99
  24. Acquired and inherent radioresistance of tumor cells is related to tumor relapse and poor prognosis – not only in head and neck squamous cell carcinoma (HNSCC). The underlying molecular mechanisms are largely ...

    Authors: Agata Michna, Ulrike Schötz, Martin Selmansberger, Horst Zitzelsberger, Kirsten Lauber, Kristian Unger and Julia Hess
    Citation: Radiation Oncology 2016 11:94
  25. Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and i...

    Authors: Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami and Akihiko Kondo
    Citation: Radiation Oncology 2016 11:91
  26. O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and...

    Authors: Marc D. Piroth, Norbert Galldiks, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Johannes Ermert, Felix M. Mottaghy, N. Jon Shah, Karl-Josef Langen and Michael J. Eble
    Citation: Radiation Oncology 2016 11:87
  27. Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is...

    Authors: Johann Matschke, Elisa Wiebeck, Sebastian Hurst, Justine Rudner and Verena Jendrossek
    Citation: Radiation Oncology 2016 11:75
  28. To study the dose-response of stage I non-small-cell lung cancer (NSCLC) in terms of long-term local tumor control (LC) after conventional and hypofractionated photon radiotherapy, modeled with the linear-quad...

    Authors: Alina Santiago, Steffen Barczyk, Urszula Jelen, Rita Engenhart-Cabillic and Andrea Wittig
    Citation: Radiation Oncology 2016 11:67
  29. Risk of normal tissue toxicity limits the amount of thoracic radiation therapy (RT) that can be routinely prescribed to treat non-small cell lung cancer (NSCLC). An early biomarker of response to thoracic RT m...

    Authors: Tru-Khang T. Dinh, Wojciech Fendler, Justyna Chałubińska-Fendler, Sanket S. Acharya, Colin O’Leary, Peter V. Deraska, Alan D. D’Andrea, Dipanjan Chowdhury and David Kozono
    Citation: Radiation Oncology 2016 11:61
  30. This study investigates the implementation of a new intensity modulated arc therapy (IMAT) class solution in comparison to a 6-static beam step-and-shoot intensity modulated radiotherapy (s-IMRT) for three-pha...

    Authors: Dieter Berwouts, Luiza Ana Maria Olteanu, Bruno Speleers, Frédéric Duprez, Indira Madani, Tom Vercauteren, Wilfried De Neve and Werner De Gersem
    Citation: Radiation Oncology 2016 11:52
  31. Glioblastomas progress rapidly making response evaluation using MRI insufficient since treatment effects are not detectable until months after initiation of treatment. Thus, there is a strong need for suppleme...

    Authors: Lina Mörén, Carl Wibom, Per Bergström, Mikael Johansson, Henrik Antti and A. Tommy Bergenheim
    Citation: Radiation Oncology 2016 11:51
  32. Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to radiotherapy alone. In this study biological modelling is a...

    Authors: J. Crezee, C. M. van Leeuwen, A. L. Oei, L. E. van Heerden, A. Bel, L. J. A. Stalpers, P. Ghadjar, N. A. P. Franken and H. P. Kok
    Citation: Radiation Oncology 2016 11:14
  33. The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of r...

    Authors: Yu-Zhe Song, Mei-Na Duan, Yu-Yu Zhang, Wei-Yan Shi, Cheng-Cheng Xia and Li-Hua Dong
    Citation: Radiation Oncology 2015 10:247
  34. Tumour hypoxia promotes radioresistance and is associated with poor prognosis. The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor (HIF)-...

    Authors: Markus Mandl, Maria- Katharina Lieberum, Juergen Dunst and Reinhard Depping
    Citation: Radiation Oncology 2015 10:229
  35. Local tumor control by standard fractionated radiotherapy (RT) remains poor because of tumor resistance to radiation (radioresistance). It has been suggested that cancer stem cells (CSCs) are more radioresista...

    Authors: Yuhchyau Chen, Fuquan Zhang, Ying Tsai, Xiadong Yang, Li Yang, Shanzhou Duan, Xin Wang, Peter Keng and Soo Ok Lee
    Citation: Radiation Oncology 2015 10:227
  36. Our previous data demonstrated that targeting non-homologous end-joining repair (NHEJR) yields a higher radiosensitivity than targeting homologous recombination repair (HRR) to heavy ions using DNA repair gene...

    Authors: Hongyu Ma, Akihisa Takahashi, Yukari Yoshida, Akiko Adachi, Tatsuaki Kanai, Tatsuya Ohno and Takashi Nakano
    Citation: Radiation Oncology 2015 10:225
  37. Radiation-induced fibrosis (RIF) is one of the severe long-term side effects of radiation therapy (RT) with a crucial impact on the development of postoperative wound healing disorders (WHD). The grades of fib...

    Authors: Steffen Koerdt, Nils H. Rohleder, Niklas Rommel, Christopher Nobis, Mechthild Stoeckelhuber, Steffi Pigorsch, Marciana-Nona Duma, Klaus-Dietrich Wolff and Marco R. Kesting
    Citation: Radiation Oncology 2015 10:202
  38. The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel act...

    Authors: Ingeborg Tinhofer, Franziska Niehr, Robert Konschak, Sandra Liebs, Matthias Munz, Albrecht Stenzinger, Wilko Weichert, Ulrich Keilholz and Volker Budach
    Citation: Radiation Oncology 2015 10:183
  39. High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is ...

    Authors: Hiroshi Fujisawa, Nakako Izumi Nakajima, Shigeaki Sunada, Younghyun Lee, Hirokazu Hirakawa, Hirohiko Yajima, Akira Fujimori, Mitsuru Uesaka and Ryuichi Okayasu
    Citation: Radiation Oncology 2015 10:175
  40. Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluation of noninvasive methods for the detection of hypoxia is therefore of interest. Osteopontin (OPN) has been discussed as a...

    Authors: Gisela Wohlleben, Agmal Scherzad, Antje Güttler, Dirk Vordermark, Sebastian Kuger, Michael Flentje and Buelent Polat
    Citation: Radiation Oncology 2015 10:167
  41. Glioblastoma is a highly lethal neoplasm that frequently recurs locally after radiotherapy, and most of these recurrences originate from near the irradiated target field. In the present study, we identified th...

    Authors: Jian Pei, In-Ho Park, Hyang-Hwa Ryu, Song-Yuan Li, Chun-Hao Li, Sa-Hoe Lim, Min Wen, Woo-Youl Jang and Shin Jung
    Citation: Radiation Oncology 2015 10:164
  42. The quantitative analysis of foci plays an important role in many cell biological methods such as counting of colonies or cells, organelles or vesicles, or the number of protein complexes. In radiation biology...

    Authors: Sebastian Oeck, Nathalie M. Malewicz, Sebastian Hurst, Justine Rudner and Verena Jendrossek
    Citation: Radiation Oncology 2015 10:163
  43. Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apop...

    Authors: Shuraila F. Zerp, T. Rianne Stoter, Frank J. P. Hoebers, Michiel W. M. van den Brekel, Ria Dubbelman, Gitta K. Kuipers, M. Vincent M. Lafleur, Ben J. Slotman and Marcel Verheij
    Citation: Radiation Oncology 2015 10:158
  44. Radioresistance is the main limit to the efficacy of radiotherapy in nasopharyngeal carcinoma (NPC). SHP-1 is involved in cancer progression, but its role in radioresistance and senescence of NPC is not well u...

    Authors: Ziyi Sun, Xiaofen Pan, Zhenwei Zou, Qian Ding, Gang Wu and Gang Peng
    Citation: Radiation Oncology 2015 10:152
  45. The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal...

    Authors: Naoya Murakami, Annett Kühnel, Thomas E. Schmid, Katarina Ilicic, Stefan Stangl, Isabella S. Braun, Mathias Gehrmann, Michael Molls, Jun Itami and Gabriele Multhoff
    Citation: Radiation Oncology 2015 10:149
  46. Considering the review by Puspitasari and colleagues, an additional discussion of the endpoints of the Se supplementation studies described would be helpful. In our view, selenium can safely be given to seleni...

    Authors: Ralph Muecke, Oliver Micke, Lutz Schomburg, Klaus Kisters, Jens Buentzel, Jutta Huebner and Jan Kriz
    Citation: Radiation Oncology 2014 9:289
  47. It has been long recognized that cranial irradiation used for the treatment of primary and metastatic brain tumor often causes neurological side-effects such as intellectual impairment, memory loss and dementi...

    Authors: Liyuan Zhang, Kun Li, Rui Sun, Yuan Zhang, JianFeng Ji, Peigeng Huang, Hongying Yang and Ye Tian
    Citation: Radiation Oncology 2014 9:281

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