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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Neurocognitive decline observed after radiotherapy (RT) for brain tumors in long time survivors is attributed to radiation exposure of the hippocampus and the subventricular zone (SVZ). The potential of sparin...

    Authors: Julia Oehler, Tim Brachwitz, Thomas G Wendt, Nico Banz, Mario Walther and Tilo Wiezorek
    Citation: Radiation Oncology 2013 8:187
  2. This study compared manually delineated gross tumour volume (GTV) and automatically generated biological tumour volume (BTV) based on fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT to assess ...

    Authors: Maximilian Niyazi, Sonja Landrock, Andreas Elsner, Farkhad Manapov, Marcus Hacker, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2013 8:180
  3. Low survival outcomes have been reported for the treatment of locally advanced non small cell lung cancer (LA-NSCLC) with the standard of care treatment of concurrent chemoradiation (cCRT). We present our expe...

    Authors: Sana D Karam, Zachary D Horne, Robert L Hong, Don McRae, David Duhamel and Nadim M Nasr
    Citation: Radiation Oncology 2013 8:179
  4. To determine prostate volume (Pvol) changes at 3 different time points during the course of I125 permanent seed brachytherapy (PB). To assess the impact of these changes on acute urinary retention (AUR) and dosim...

    Authors: Ciprian Chira, Guila Delouya, Sandra Larrivée, Jean-Francois Carrier and Daniel Taussky
    Citation: Radiation Oncology 2013 8:177
  5. Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with high single-doses are successfully applied in many centers in pa...

    Authors: Daniel Habermehl, Klaus K Herfarth, Justo Lorenzo Bermejo, Holger Hof, Stefan Rieken, Sabine Kuhn, Thomas Welzel, Jürgen Debus and Stephanie E Combs
    Citation: Radiation Oncology 2013 8:175
  6. Tumor human papillomavirus (HPV) status has emerged as one of the most powerful prognostic factors for disease control and survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). We reviewed o...

    Authors: Trevor J Bledsoe, Anisha R Noble, Grant K Hunter, Lisa A Rybicki, Aaron Hoschar, Deborah J Chute, Jerrold P Saxton, John F Greskovich, David J Adelstein and Shlomo A Koyfman
    Citation: Radiation Oncology 2013 8:174
  7. To evaluate the feasibility and early side effects of a short course hypo-fractionated SBRT programme with Volumetric Modulated Arc Therapy (VMAT) and Flattening Filter Free (FFF) beams.

    Authors: Filippo Alongi, Luca Cozzi, Stefano Arcangeli, Cristina Iftode, Tiziana Comito, Elisa Villa, Francesca Lobefalo, Pierina Navarria, Giacomo Reggiori, Pietro Mancosu, Elena Clerici, Antonella Fogliata, Stefano Tomatis, Gianluigi Taverna, Pierpaolo Graziotti and Marta Scorsetti
    Citation: Radiation Oncology 2013 8:171
  8. The ideal prostate-specific antigen (PSA) doubling time (PSADT) threshold for identifying patients at high-risk for poor clinical outcome following salvage radiation therapy (SRT) has not been well established...

    Authors: William C Jackson, Skyler B Johnson, Darren Li, Corey Foster, Benjamin Foster, Yeohan Song, Matthew Schipper, Mark Shilkrut, Howard M Sandler, Todd M Morgan, Ganesh S Palapattu, Daniel A Hamstra and Felix Y Feng
    Citation: Radiation Oncology 2013 8:170
  9. To analyze the longitudinal length accuracy of gross tumor volume (GTV) delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma (SCC).

    Authors: Dong-Liang Hou, Gao-Feng Shi, Xian-Shu Gao, Junichi Asaumi, Xue-Ying Li, Hui Liu, Chen Yao and Joe Y Chang
    Citation: Radiation Oncology 2013 8:169
  10. The purpose of this study was to analyze the efficacy and tolerability of palliative radiotherapy (RT) in patients with a poor performance status (PS) and to evaluate the relationship between the palliative ef...

    Authors: Shinsaku Yamaguchi, Takayuki Ohguri, Yuichi Matsuki, Katsuya Yahara, Hiroyuki Narisada, Hajime Imada and Yukunori Korogi
    Citation: Radiation Oncology 2013 8:166
  11. Localization of the tumor bed of breast cancer is crucial for accurate planning of boost irradiation. Lumpectomy cavity and surgical clips provide localizing information about tumor bed. However, defining the ...

    Authors: Oyeon Cho, Mison Chun, Young Taek Oh, Mi Hwa Kim, Hae Jin Park, Jae Sung Heo and O Kyu Noh
    Citation: Radiation Oncology 2013 8:163
  12. First, to evaluate outcome, the benefit of concurrent chemotherapy and prognostic factors in a cohort of sixty-four high-grade glioma patients who underwent a second course of radiation therapy at progression....

    Authors: Felix Scholtyssek, Isabella Zwiener, Annika Schlamann, Clemens Seidel, Jürgen Meixensberger, Manfred Bauer, Karl-Titus Hoffmann, Stephanie E Combs, André O von Bueren, Rolf-Dieter Kortmann and Klaus Müller
    Citation: Radiation Oncology 2013 8:161
  13. Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes of chemoradiotherapy (C...

    Authors: Yeon-Joo Kim, Woo Jin Lee, Sang Myung Woo, Tae Hyun Kim, Sung Sik Han, Bo Hyun Kim, Sung Ho Moon, Sang Soo Kim, Young Hwan Koh, Sang Jae Park, Joo Young Kim, Dae Yong Kim and Joong Won Park
    Citation: Radiation Oncology 2013 8:160
  14. To assess the efficacy and safety of stereotactic body radiotherapy (SBRT) in patients with either unresectable locally advanced pancreatic adenocarcinoma or by locally recurrent disease after surgery.

    Authors: Angelo Tozzi, Tiziana Comito, Filippo Alongi, Pierina Navarria, Cristina Iftode, Pietro Mancosu, Giacomo Reggiori, Elena Clerici, Lorenza Rimassa, Alessandro Zerbi, Antonella Fogliata, Luca Cozzi, Stefano Tomatis and Marta Scorsetti
    Citation: Radiation Oncology 2013 8:148
  15. Primary cutaneous follicle center lymphoma is an indolent primary cutaneous B-cell lymphoma originating from the follicle center cells, composed of a combination of centrocytes (small and large cleaved cells) ...

    Authors: Romana Ceovic, Ivana Jovanovic, Kresimir Kostovic, Jaka Rados, Snjezana Dotlic, Ivo Radman, Sandra Marinovic Kulisic and Davorin Loncaric
    Citation: Radiation Oncology 2013 8:147
  16. In a previous report, we compared the conformity of robust intensity-modulated proton therapy (IMPT) plans with that of helical tomotherapy plans for re-irradiations of head and neck carcinomas using a fixed s...

    Authors: Martin Stuschke, Andreas Kaiser, Jehad Abu Jawad, Christoph Pöttgen, Sabine Levegrün and Jonathan Farr
    Citation: Radiation Oncology 2013 8:145
  17. To quantify the development of radiation neuropathy in corneal subbasal nerve plexus (SNP) after plaque brachytherapy, and the subsequent regeneration of SNP micromorphology and corneal sensation.

    Authors: Andrey Zhivov, Karsten Winter, Sabine Peschel, Oliver Stachs, Andreas Wree, Guido Hildebrandt and Rudolf Guthoff
    Citation: Radiation Oncology 2013 8:136
  18. Neoadjuvant chemoradiation has become the standard treatment in locally advanced rectal cancer (LARC) and improves local control. This study explored the feasibility of an intensified chemoradiation treatment ...

    Authors: Ji Zhu, Weilie Gu, Peng Lian, Weiqi Sheng, Gang Cai, Debing Shi, Sanjun Cai and Zhen Zhang
    Citation: Radiation Oncology 2013 8:130
  19. Several single institution phase I and phase II trials of stereotactic ablative body radiotherapy (SABR) for liver tumors have reported promising results and high local control rates of over 90%. However, ther...

    Authors: Takahisa Eriguchi, Atsuya Takeda, Yohei Oku, Satoshi Ishikura, Tomoki Kimura, Shuichi Ozawa, Takeo Nakashima, Yukinori Matsuo, Mitsuhiro Nakamura, Yasuo Matsumoto, Sadanori Yamazaki, Naoko Sanuki and Yoshinori Ito
    Citation: Radiation Oncology 2013 8:113
  20. To analyze setup deviations using daily megavoltage computed tomography (MVCT) and to evaluate three MVCT frequency reducing protocols for gynecologic cancer patients treated with helical tomotherapy.

    Authors: Carmen Stromberger, Arne Gruen, Waldemar Wlodarczyk, Volker Budach, Christhardt Koehler and Simone Marnitz
    Citation: Radiation Oncology 2013 8:110
  21. This study investigates the variation in segmentation of several pelvic anatomical structures on computed tomography (CT) between multiple observers and a commercial automatic segmentation method, in the conte...

    Authors: John P Geraghty, Garry Grogan and Martin A Ebert
    Citation: Radiation Oncology 2013 8:106
  22. To test the hypothesis that the therapeutic ratio of intensity-modulated photon therapy using helical tomotherapy (HT) for retreatment of head and neck carcinomas can be improved by robust intensity-modulated ...

    Authors: Martin Stuschke, Andreas Kaiser, Jehad Abu-Jawad, Christoph Pöttgen, Sabine Levegrün and Jonathan Farr
    Citation: Radiation Oncology 2013 8:93

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