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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  2. Image-guided radiotherapy (IGRT) facilitates the delivery of a very precise radiation dose. In this study we compare the toxicity and biochemical progression-free survival between patients treated with daily i...

    Authors: Joen Sveistrup, Per Munck af Rosenschöld, Joseph O Deasy, Jung Hun Oh, Tobias Pommer, Peter Meidahl Petersen and Svend Aage Engelholm
    Citation: Radiation Oncology 2014 9:44
    Content type: Research Published on:

  3. Patients with early stage prostate cancer have a variety of curative radiotherapy options, including conventionally-fractionated external beam radiotherapy (CF-EBRT) and hypofractionated stereotactic body radi...

    Authors: Mekhail Anwar, Vivian Weinberg, Albert J Chang, I-Chow Hsu, Mack Roach III and Alexander Gottschalk
    Citation: Radiation Oncology 2014 9:42
    Content type: Research Published on:

  4. This retrospective study aims to assess the usefulness of SUVmax from FDG-PET imaging as a prognosticator for primary biopsy-proven stage I NSCLC treated with SBRT.

    Authors: Zachary D Horne, David A Clump, John A Vargo, Samir Shah, Sushil Beriwal, Steven A Burton, Annette E Quinn, Matthew J Schuchert, Rodney J Landreneau, Neil A Christie, James D Luketich and Dwight E Heron
    Citation: Radiation Oncology 2014 9:41
    Content type: Research Published on:

  5. Anal canal carcinoma is a rare gastro-intestinal cancer. Radiochemotherapy is the recommended primary treatment for patients with non-metastatic carcinoma; surgery is generally reserved for persistent or recur...

    Authors: Daniela Musio, Francesca De Felice, Nicola Raffetto and Vincenzo Tombolini
    Citation: Radiation Oncology 2014 9:39
    Content type: Review Published on:

  6. While most meningiomas are benign, aggressive meningiomas are associated with high levels of recurrence and mortality. A single institution’s Gamma Knife radiosurgical experience with atypical and malignant me...

    Authors: Daniel J Ferraro, Ryan K Funk, John William Blackett, Michelle R Ju, Todd A DeWees, Michael R Chicoine, Joshua L Dowling, Keith M Rich, Robert E Drzymala, Imran Zoberi, Joseph R Simpson and Jerry J Jaboin
    Citation: Radiation Oncology 2014 9:38
    Content type: Research Published on:

  7. To study whether esophageal FDG activity changes by time of mid-course of fractionated radiotherapy (RT), and whether these changes are associated with radiation esophagitis in patients with non-small cell lun...

    Authors: Shuanghu Tiger Yuan, Richard KJ Brown, Lujun Zhao, Randall K Ten Haken, Milton Gross, Kemp B Cease, Matt Schipper, Paul Stanton, Jinming Yu and Feng-Ming Spring Kong
    Citation: Radiation Oncology 2014 9:37
    Content type: Research Published on:

  8. Today it is unclear which technique for delivery of an additional boost after whole breast radiotherapy for breast conserved patients should be state of the art. We present a dosimetric comparison of different...

    Authors: Hilde Van Parijs, Truus Reynders, Karina Heuninckx, Dirk Verellen, Guy Storme and Mark De Ridder
    Citation: Radiation Oncology 2014 9:36
    Content type: Research Published on:

  9. Three-dimensional ultrasound (3DUS) at simulation compared to 3DUS at treatment is an image guidance option for partial breast irradiation (PBI). This study assessed if user dependence in acquiring and contour...

    Authors: Anthony Landry, Tanya Berrang, Isabelle Gagne, Carmen Popescu, Tracy Mitchell, Hazel Vey, Letricia Sand, Siew Yan Soh, Jill Wark, Ivo Olivotto and Wayne Beckham
    Citation: Radiation Oncology 2014 9:35
    Content type: Research Published on:

  10. The randomized TARGIT trial comparing experimental intra-operative radiotherapy (IORT) to up to 7 weeks of daily conventional external beam radiotherapy (EBRT) recruited participants in Western Australia betwe...

    Authors: Tammy Corica, David Joseph, Christobel Saunders, Max Bulsara and Anna K Nowak
    Citation: Radiation Oncology 2014 9:33
    Content type: Research Published on:

  11. Radiotherapy (RT) is currently under investigation as part of a trimodality treatment of malignant pleural mesothelioma (MPM). The introduction of highly conformal radiotherapy (HCRT) technique improved dose d...

    Authors: Jérôme Krayenbuehl, Peter Dimmerling, I Frank Ciernik and Oliver Riesterer
    Citation: Radiation Oncology 2014 9:32
    Content type: Research Published on:

  12. Purpose of this study was to identify predictors of vaginal ulcer after CT based three-dimensional image-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for gynecologic malignancies.

    Authors: Naoya Murakami, Takahiro Kasamatsu, Minako Sumi, Ryoichi Yoshimura, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Kana Takahashi, Kotaro Yoshio, Koji Inaba, Madoka Morota, Yoshinori Ito and Jun Itami
    Citation: Radiation Oncology 2014 9:31
    Content type: Research Published on:

  13. To evaluate the effects of radiation therapy on deciduous teeth.

    Authors: Talitha de Siqueira Mellara, Regina Guenka Palma-Dibb, Harley Francisco de Oliveira, Francisco Wanderley Garcia Paula-Silva, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva, Léa Assed Bezerra da Silva and Alexandra Mussolino de Queiroz
    Citation: Radiation Oncology 2014 9:30
    Content type: Research Published on:

  14. The aim of this study was to evaluate the effects of radiotherapy plus concurrent weekly cisplatin chemotherapy on the postoperative recurrence of mediastinal lymph node metastases in esophageal cancer patients.

    Authors: Dai-yuan Ma, Bang-xian Tan, Mi Liu, Xian-fu Li, Ye-qin Zhou and You Lu
    Citation: Radiation Oncology 2014 9:28
    Content type: Research Published on:

  15. The tumor removal of Cavernous Sinus Meningiomas usually results in severe neurological deficits. Stereotactic radiosurgery (SRS) and fractionated Stereotactic radiotherapy (SRT) are advanced modalities of rad...

    Authors: Sebastião Francisco Miranda Correa, Gustavo Nader Marta and Manoel Jacobsen Teixeira
    Citation: Radiation Oncology 2014 9:27
    Content type: Research Published on:

  16. We examined the efficacy and toxicity of proton beam therapy (PBT) for treating advanced cholangiocarcinoma.

    Authors: Chiyoko Makita, Tatsuya Nakamura, Akinori Takada, Kanako Takayama, Motohisa Suzuki, Yojiro Ishikawa, Yusuke Azami, Takahiro Kato, Iwao Tsukiyama, Yasuhiro Kikuchi, Masato Hareyama, Masao Murakami, Nobukazu Fuwa, Masaharu Hata and Tomio Inoue
    Citation: Radiation Oncology 2014 9:26
    Content type: Research Published on:

  17. The optimal management of high-risk prostate cancer remains uncertain. In this study we assessed the safety and efficacy of a novel multimodal treatment paradigm for high-risk prostate cancer.

    Authors: Andrea Guttilla, Roberto Bortolus, Gianluca Giannarini, Pirus Ghadjar, Fabio Zattoni, Michele Gnech, Vito Palumbo, Francesca Valent, Antonio Garbeglio and Filiberto Zattoni
    Citation: Radiation Oncology 2014 9:24
    Content type: Study protocol Published on:

  19. Hypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension dur...

    Authors: Adalsteinn Gunnlaugsson, Elisabeth Kjellén, Oskar Hagberg, Camilla Thellenberg-Karlsson, Anders Widmark and Per Nilsson
    Citation: Radiation Oncology 2014 9:22
    Content type: Research Published on:

  21. To determine the impact of body-mass factors (BMF) before radiotherapy and changes during radiotherapy on the magnitude of setup displacement in patients with head and neck cancer (HNC).

    Authors: Yo-Liang Lai, Shih-Neng Yang, Ji-An Liang, Yao-Ching Wang, Chun-Yen Yu, Ching-Hsiung Su and Shang-Wen Chen
    Citation: Radiation Oncology 2014 9:19
    Content type: Research Published on:

  22. To report technical features, early outcome and toxicity of stereotactic body radiation therapy (SBRT) treatments with volumetric modulated arc therapy (RapidArc) for patients with hepatocellular carcinoma (HCC).

    Authors: Po-Ming Wang, Wei-Chung Hsu, Na-Na Chung, Feng-Ling Chang, Chin-Jyh Jang, Antonella Fogliata, Marta Scorsetti and Luca Cozzi
    Citation: Radiation Oncology 2014 9:18
    Content type: Research Published on:

  24. The aim of this study was to quantify the variation in doses to organs at risk (ipsilateral lung and heart) and the clinical target volume (CTV) in the presence of breast implants. In this retrospective cohort...

    Authors: Annelie Liljegren, Dmytro Unukovych, Giovanna Gagliardi, Judith Bjöhle, Marie Wickman, Hemming Johansson and Kerstin Sandelin
    Citation: Radiation Oncology 2014 9:14
    Content type: Research Published on:

  25. To report the outcomes of patients treated with combined iodine-125 (I-125) brachytherapy and external beam radiotherapy (EBRT) for high-risk prostate cancer.

    Authors: Toshio Ohashi, Atsunori Yorozu, Shiro Saito, Tetsuo Momma, Toru Nishiyama, Shoji Yamashita, Yutaka Shiraishi and Naoyuki Shigematsu
    Citation: Radiation Oncology 2014 9:13
    Content type: Research Published on:

  26. The purpose of this clinical study is to investigate the clinical feasibility and safety of a shuttle-based MR-linac connection to provide MR-guided radiotherapy.

    Authors: Tilman Bostel, Nils H Nicolay, Jörg G Grossmann, Angela Mohr, Stefan Delorme, Gernot Echner, Peter Häring, Jürgen Debus and Florian Sterzing
    Citation: Radiation Oncology 2014 9:12
    Content type: Study protocol Published on:

  27. To evaluate use of breath-hold CTs and implanted fiducials for definition of the internal target volume (ITV) margin for upper abdominal stereotactic body radiation therapy (SBRT). To study the statistics of i...

    Authors: Wensha Yang, Benedick A Fraass, Robert Reznik, Nicholas Nissen, Simon Lo, Laith H Jamil, Kapil Gupta, Howard Sandler and Richard Tuli
    Citation: Radiation Oncology 2014 9:11
    Content type: Research Published on:

  28. Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique singl...

    Authors: Judit Boda-Heggemann, Anian Frauenfeld, Christel Weiss, Anna Simeonova, Christian Neumaier, Kerstin Siebenlist, Ulrike Attenberger, Claus Peter Heußel, Frank Schneider, Frederik Wenz and Frank Lohr
    Citation: Radiation Oncology 2014 9:10
    Content type: Research Published on:

  29. In patients with highly advanced gastric cancer, the recurrence rate remains high and the prognosis disappointing. We previously reported a phase I study of a neoadjuvant chemoradiotherapy of S-1 plus weekly c...

    Authors: Satoru Matsuda, Tsunehiro Takahashi, Junichi Fukada, Kazumasa Fukuda, Hirofumi Kawakubo, Yoshiro Saikawa, Osamu Kawaguchi, Hiroya Takeuchi, Naoyuki Shigematsu and Yuko Kitagawa
    Citation: Radiation Oncology 2014 9:9
    Content type: Research Published on:

    The Erratum to this article has been published in Radiation Oncology 2014 9:140

  30. The overall treatment time of stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer is usually 3 to over 10 days. If it is longer than 7 days, tumor volume expansion during SBRT may jeopardize t...

    Authors: Kotoha Tatekawa, Hiromitsu Iwata, Takatsune Kawaguchi, Satoshi Ishikura, Fumiya Baba, Shinya Otsuka, Akifumi Miyakawa, Maho Iwana and Yuta Shibamoto
    Citation: Radiation Oncology 2014 9:8
    Content type: Research Published on:

  31. The N1 definition of 2010 UICC/AJCC staging system for nasopharyngeal carcinoma (NPC) covers quite a large range of nodal pattern. The objective of this research is to investigate prognostic value of lymph nod...

    Authors: Qi Shi, Chunying Shen, Lin Kong, Xiaoshen Wang, Jianhui Ding, Yunsheng Gao, Tingting Xu and Chaosu Hu
    Citation: Radiation Oncology 2014 9:7
    Content type: Research Published on:

  32. Recurrent malignant gliomas (RMGs) are very difficult to control, and no standard treatments have been established for them. We performed boron neutron capture therapy (BNCT) for patients with RMG. BNCT enable...

    Authors: Shin-Ichi Miyatake, Shinji Kawabata, Ryo Hiramatsu, Motomasa Furuse, Toshihiko Kuroiwa and Minoru Suzuki
    Citation: Radiation Oncology 2014 9:6
    Content type: Case report Published on:

  34. The increase in relative biological effectiveness (RBE) of proton beams at the distal edge of the spread out Bragg peak (SOBP) is a well-known phenomenon that is difficult to quantify accurately in vivo. For purp...

    Authors: Jeffrey C Buchsbaum, Mark W McDonald, Peter AS Johnstone, Ted Hoene, Marc Mendonca, Chee-Wei Cheng, Indra J Das, Kevin P McMullen and Mark R Wolanski
    Citation: Radiation Oncology 2014 9:2
    Content type: Research Published on:

  35. Stereotactic Body Radiotherapy (SBRT) has excellent control rates for low- and intermediate-risk prostate carcinoma.The role of SBRT for high-risk disease remains less studied. We present long-term results on ...

    Authors: Alan Katz and Josephine Kang
    Citation: Radiation Oncology 2014 9:1
    Content type: Research Published on:

  36. The aim of this trial was to investigate neurological outcome after emergency RT in MSCC of NSCLC patients with acute neurological deficit.

    Authors: Harald Rief, Rita C Heinhold, Lina C Petersen, Stefan Rieken, Thomas Bruckner, Arash Moghaddam-Alvandi, Jürgen Debus and Florian Sterzing
    Citation: Radiation Oncology 2013 8:297
    Content type: Research Published on:

  38. For treatment of the entire cranium using passive scattering proton therapy (PSPT) compensators are often employed in order to reduce lens and cochlear exposure. We sought to assess the advantages and conseque...

    Authors: Jeffrey Dinh, Joshua Stoker, Rola H Georges, Narayan Sahoo, X Ronald Zhu, Smruti Rath, Anita Mahajan and David R Grosshans
    Citation: Radiation Oncology 2013 8:289
    Content type: Methodology Published on:

  39. The purpose of the study is to evaluate the long-term clinical outcome through biochemical no evidence of disease (bNED) rates among men with low to intermediate risk prostate cancer treated with two different...

    Authors: Haim Matzkin, Juza Chen, Larissa German and Nicola J Mabjeesh
    Citation: Radiation Oncology 2013 8:288
    Content type: Research Published on:

  40. Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data is available allowing for a precise selec...

    Authors: Maximilian Niyazi, Ivan Karin, Matthias Söhn, Silke B Nachbichler, Peter Lang, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2013 8:287
    Content type: Research Published on:

  41. Meta-analysis of randomized trials has shown that postoperative radiotherapy (PORT) had a detrimental effect on overall survival (OS) in patients with resected N1 non–small cell lung cancer (NSCLC). Conversely...

    Authors: Chengcheng Fan, Shugeng Gao, Zhouguang Hui, Jun Liang, Jima Lv, Xiaozhen Wang, Jie He and Luhua Wang
    Citation: Radiation Oncology 2013 8:286
    Content type: Research Published on:

  42. Clinically localized prostate cancer may be treated by different approaches of radiation therapy. The aim of this study was to report the results of disease control and toxicity in patients with clinically loc...

    Authors: Rafael Gadia, Élton T Leite, Flavia G Gabrielli, Gustavo N Marta, Fernando F Arruda, Carlos V Abreu, Samir A Hanna, Cecilia K Haddad, João F Silva, Heloisa A Carvalho and Bernardo Garicochea
    Citation: Radiation Oncology 2013 8:285
    Content type: Research Published on:

  43. To analyze our experience with intraoperative electron radiation therapy (IOERT) followed by moderate doses of external beam radiation therapy (EBRT) in patients with locally recurrent renal cell carcinoma.

    Authors: Gregor Habl, Matthias Uhl, Frank Hensley, Sascha Pahernik, Juergen Debus and Falk Röder
    Citation: Radiation Oncology 2013 8:282
    Content type: Research Published on:

  45. To compare the accuracy of different imaging modalities, alone and in combination in predicting findings at surgery after preoperative chemoradiation for locally advanced rectal cancer.

    Authors: Ram Dickman, Yulia Kundel, Rachel Levy-Drummer, Ofer Purim, Nir Wasserberg, Eyal Fenig, Aaron Sulkes and Baruch Brenner
    Citation: Radiation Oncology 2013 8:278
    Content type: Research Published on:

  46. Evaluation of dose escalated salvage radiotherapy (SRT) in patients after radical prostatectomy (RP) who had never received antihormonal therapy. To investigate prognostic factors of the outcome of SRT and to ...

    Authors: Mohamed Shelan, Yasser Abo-Madyan, Grit Welzel, Christian Bolenz, Julia Kosakowski, Nadim Behnam, Frederik Wenz and Frank Lohr
    Citation: Radiation Oncology 2013 8:276
    Content type: Research Published on:

  47. The RSSearchâ„¢ Registry is a multi-institutional, observational, ongoing registry established to standardize data collection from patients treated with stereotactic radiosurgery (SRS) and/or stereotactic body r...

    Authors: Joanne N Davis, Clinton Medbery III, Sanjeev Sharma, Adnan Danish and Anand Mahadevan
    Citation: Radiation Oncology 2013 8:275
    Content type: Methodology Published on:

  49. Flattening filter-free (FFF) linear accelerators (linacs) are capable of delivering dose rates more than 4-times higher than conventional linacs during SBRT treatments, causing some to speculate whether the hi...

    Authors: Brendan M Prendergast, Michael C Dobelbower, James A Bonner, Richard A Popple, Craig J Baden, Douglas J Minnich, Robert J Cerfolio, Sharon A Spencer and John B Fiveash
    Citation: Radiation Oncology 2013 8:273
    Content type: Research Published on:

  50. The aim of the present study was to evaluate the prevalence and severity of lower limb lymphedema after pelvic lymphadenectomy and radiotherapy to the pelvic lymph nodes in patients with prostate cancer.

    Authors: Elisabeth Rasmusson, Adalsteinn Gunnlaugsson, René Blom, Thomas Björk-Eriksson, Per Nilsson, Göran Ahlgen, Charlotta Jönsson, Karin Johansson and Elisabeth Kjellén
    Citation: Radiation Oncology 2013 8:271
    Content type: Research Published on:
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Radiation Oncology

ISSN: 1748-717X

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