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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. The α/β ratio for prostate cancer is postulated being in the range of 0.8 to 2.2 Gy, giving rise to the hypothesis that there may be a therapeutic advantage to hypofractionation. To do so, we carried out a random...

    Authors: Darius Norkus, Agata Karklelyte, Benedikt Engels, Harijati Versmessen, Romas Griskevicius, Mark De Ridder, Guy Storme, Eduardas Aleknavicius, Ernestas Janulionis and Konstantinas Povilas Valuckas

    Citation: Radiation Oncology 2013 8:206

    Content type: Research

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  2. Survival of patients with brain metastasis particularly from historically more radio-resistant malignancies remains dismal. A phase I study of concurrent bortezomib and whole brain radiotherapy was conducted t...

    Authors: Christopher D Lao, Judah Friedman, Christina I Tsien, Daniel P Normolle, Christopher Chapman, Yue Cao, Oliver Lee, Matt Schipper, Catherine Van Poznak, Daniel Hamstra, Theodore Lawrence, James Hayman and Bruce G Redman

    Citation: Radiation Oncology 2013 8:204

    Content type: Research

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  3. Accelerated hypofractionated radiotherapy can shorten total treatment time and overcome the accelerated repopulation of tumour cells during radiotherapy. This therapeutic approach has demonstrated good efficac...

    Authors: Qiang Lin, Yue-E Liu, Xiao-Cang Ren, Na Wang, Xue-Ji Chen, Dong-Ying Wang, Jie Zong, Yu Peng, Zhi-Jun Guo and Jing Hu

    Citation: Radiation Oncology 2013 8:201

    Content type: Research

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  4. The objective of this retrospective analysis is to systematically assess osseous lesions on the basis of a validated scoring system in terms of stability and fractures prior to and following radiotherapy in 33...

    Authors: Harald Rief, Marc Bischof, Thomas Bruckner, Thomas Welzel, Vasileios Askoxylakis, Stefan Rieken, Katja Lindel, Stephanie Combs and Jürgen Debus

    Citation: Radiation Oncology 2013 8:200

    Content type: Research

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  5. The role of adjuvant radiotherapy (RT) for patients with stage III thymoma after complete resection is not definite. Some authors have advocated postoperative RT after complete tumor resection, but some others...

    Authors: Chengcheng Fan, Qinfu Feng, Yidong Chen, Yirui Zhai, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Hongxing Zhang, Jian Li, Zhouguang Hui, Jun Liang, Jima Lv, Yousheng Mao, Luhua Wang and Jie He

    Citation: Radiation Oncology 2013 8:199

    Content type: Research

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  6. Increasing the radiotherapy dose can result in improved local control for non-small-cell lung cancer (NSCLC) and can thereby improve survival. Accelerated hypofractionated radiotherapy can expose tumors to a h...

    Authors: Yue-E Liu, Qiang Lin, Fan-Jie Meng, Xue-Ji Chen, Xiao-Cang Ren, Bin Cao, Na Wang, Jie Zong, Yu Peng, Ya-Jun Ku and Yan Chen

    Citation: Radiation Oncology 2013 8:198

    Content type: Research

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  7. Treating prostate cancer with SBRT could potentially minimize radiation proctitis by reducing high-dose rectal irradiation. In addition, it offers the potential radiobiologic benefits of hypofractionation. Thi...

    Authors: Sumit Sood, Andrew W Ju, Honkung Wang, Siyuan Lei, Sunghae Uhm, Guowei Zhang, Simeng Suy, John Carroll, John Lynch, Anatoly Dritschilo and Sean P Collins

    Citation: Radiation Oncology 2013 8:197

    Content type: Research

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  8. Radiologic response of brain tumors is traditionally assessed according to the Macdonald criteria 10 weeks from the start of therapy. Because glioblastoma (GB) responds in days rather than weeks after boron ne...

    Authors: Ryo Hiramatsu, Shinji Kawabata, Motomasa Furuse, Shin-Ichi Miyatake and Toshihiko Kuroiwa

    Citation: Radiation Oncology 2013 8:192

    Content type: Research

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  9. The Montpellier cancer institute phase II trial started in 2004 and evaluated the feasibility of intraoperative radiotherapy (IORT) technique given as a sole radiation treatment for patients with an excellent ...

    Authors: Claire Lemanski, David Azria, Sophie Gourgou-Bourgade, Norbert Ailleres, Aurelie Pastant, Philippe Rouanet, Pascal Fenoglietto, Jean-Bernard Dubois and Marian Gutowski

    Citation: Radiation Oncology 2013 8:191

    Content type: Study protocol

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  10. The prognosis of prostate cancer patients with lymph node metastases so small they can only be visualized by new imaging techniques as MR lymphography (MRL) is unknown. The purpose of this study was to investi...

    Authors: Hanneke JM Meijer, Oscar A Debats, Emile NJTh van Lin, Johannes Alfred Witjes, Johannes HAM Kaanders and Jelle O Barentsz

    Citation: Radiation Oncology 2013 8:190

    Content type: Research

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  11. The vascular endothelial cells are important targets of radiotherapy, which may be involved in the pathogenesis of radiation pneumonitis (RP). This study investigated the variations of circulating endothelial ...

    Authors: Yunfang Liu, Tingyi Xia, Wenjun Zhang, Yongjie Zhong, Luhua Zhang, Xuan Wang and Huiming Yu

    Citation: Radiation Oncology 2013 8:189

    Content type: Research

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  12. Increasing use of IMRT to treat breast and prostate cancers at high risk of regional nodal spread relies on accurate contouring of targets and organs at risk, which is subject to significant inter- and intra-o...

    Authors: Vikram M Velker, George B Rodrigues, Robert Dinniwell, Jeremiah Hwee and Alexander V Louie

    Citation: Radiation Oncology 2013 8:188

    Content type: Research

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  13. Neurocognitive decline observed after radiotherapy (RT) for brain tumors in long time survivors is attributed to radiation exposure of the hippocampus and the subventricular zone (SVZ). The potential of sparin...

    Authors: Julia Oehler, Tim Brachwitz, Thomas G Wendt, Nico Banz, Mario Walther and Tilo Wiezorek

    Citation: Radiation Oncology 2013 8:187

    Content type: Research

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  14. This study compared manually delineated gross tumour volume (GTV) and automatically generated biological tumour volume (BTV) based on fluoro-deoxy-glucose (FDG) positron emission tomography (PET)/CT to assess ...

    Authors: Maximilian Niyazi, Sonja Landrock, Andreas Elsner, Farkhad Manapov, Marcus Hacker, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2013 8:180

    Content type: Research

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  15. Low survival outcomes have been reported for the treatment of locally advanced non small cell lung cancer (LA-NSCLC) with the standard of care treatment of concurrent chemoradiation (cCRT). We present our expe...

    Authors: Sana D Karam, Zachary D Horne, Robert L Hong, Don McRae, David Duhamel and Nadim M Nasr

    Citation: Radiation Oncology 2013 8:179

    Content type: Research

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  16. To determine prostate volume (Pvol) changes at 3 different time points during the course of I125 permanent seed brachytherapy (PB). To assess the impact of these changes on acute urinary retention (AUR) and dosim...

    Authors: Ciprian Chira, Guila Delouya, Sandra Larrivée, Jean-Francois Carrier and Daniel Taussky

    Citation: Radiation Oncology 2013 8:177

    Content type: Research

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  17. Local ablative therapies such as stereotactically guided single-dose radiotherapy or helical intensity-modulated radiotherapy (tomotherapy) with high single-doses are successfully applied in many centers in pa...

    Authors: Daniel Habermehl, Klaus K Herfarth, Justo Lorenzo Bermejo, Holger Hof, Stefan Rieken, Sabine Kuhn, Thomas Welzel, Jürgen Debus and Stephanie E Combs

    Citation: Radiation Oncology 2013 8:175

    Content type: Research

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  18. Tumor human papillomavirus (HPV) status has emerged as one of the most powerful prognostic factors for disease control and survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). We reviewed o...

    Authors: Trevor J Bledsoe, Anisha R Noble, Grant K Hunter, Lisa A Rybicki, Aaron Hoschar, Deborah J Chute, Jerrold P Saxton, John F Greskovich, David J Adelstein and Shlomo A Koyfman

    Citation: Radiation Oncology 2013 8:174

    Content type: Research

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  19. To evaluate the feasibility and early side effects of a short course hypo-fractionated SBRT programme with Volumetric Modulated Arc Therapy (VMAT) and Flattening Filter Free (FFF) beams.

    Authors: Filippo Alongi, Luca Cozzi, Stefano Arcangeli, Cristina Iftode, Tiziana Comito, Elisa Villa, Francesca Lobefalo, Pierina Navarria, Giacomo Reggiori, Pietro Mancosu, Elena Clerici, Antonella Fogliata, Stefano Tomatis, Gianluigi Taverna, Pierpaolo Graziotti and Marta Scorsetti

    Citation: Radiation Oncology 2013 8:171

    Content type: Research

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  20. The ideal prostate-specific antigen (PSA) doubling time (PSADT) threshold for identifying patients at high-risk for poor clinical outcome following salvage radiation therapy (SRT) has not been well established...

    Authors: William C Jackson, Skyler B Johnson, Darren Li, Corey Foster, Benjamin Foster, Yeohan Song, Matthew Schipper, Mark Shilkrut, Howard M Sandler, Todd M Morgan, Ganesh S Palapattu, Daniel A Hamstra and Felix Y Feng

    Citation: Radiation Oncology 2013 8:170

    Content type: Research

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  21. To analyze the longitudinal length accuracy of gross tumor volume (GTV) delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma (SCC).

    Authors: Dong-Liang Hou, Gao-Feng Shi, Xian-Shu Gao, Junichi Asaumi, Xue-Ying Li, Hui Liu, Chen Yao and Joe Y Chang

    Citation: Radiation Oncology 2013 8:169

    Content type: Research

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  22. The purpose of this study was to analyze the efficacy and tolerability of palliative radiotherapy (RT) in patients with a poor performance status (PS) and to evaluate the relationship between the palliative ef...

    Authors: Shinsaku Yamaguchi, Takayuki Ohguri, Yuichi Matsuki, Katsuya Yahara, Hiroyuki Narisada, Hajime Imada and Yukunori Korogi

    Citation: Radiation Oncology 2013 8:166

    Content type: Research

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  23. Localization of the tumor bed of breast cancer is crucial for accurate planning of boost irradiation. Lumpectomy cavity and surgical clips provide localizing information about tumor bed. However, defining the ...

    Authors: Oyeon Cho, Mison Chun, Young Taek Oh, Mi Hwa Kim, Hae Jin Park, Jae Sung Heo and O Kyu Noh

    Citation: Radiation Oncology 2013 8:163

    Content type: Research

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  24. First, to evaluate outcome, the benefit of concurrent chemotherapy and prognostic factors in a cohort of sixty-four high-grade glioma patients who underwent a second course of radiation therapy at progression....

    Authors: Felix Scholtyssek, Isabella Zwiener, Annika Schlamann, Clemens Seidel, Jürgen Meixensberger, Manfred Bauer, Karl-Titus Hoffmann, Stephanie E Combs, André O von Bueren, Rolf-Dieter Kortmann and Klaus Müller

    Citation: Radiation Oncology 2013 8:161

    Content type: Research

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  25. Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes of chemoradiotherapy (C...

    Authors: Yeon-Joo Kim, Woo Jin Lee, Sang Myung Woo, Tae Hyun Kim, Sung Sik Han, Bo Hyun Kim, Sung Ho Moon, Sang Soo Kim, Young Hwan Koh, Sang Jae Park, Joo Young Kim, Dae Yong Kim and Joong Won Park

    Citation: Radiation Oncology 2013 8:160

    Content type: Research

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  26. To assess the efficacy and safety of stereotactic body radiotherapy (SBRT) in patients with either unresectable locally advanced pancreatic adenocarcinoma or by locally recurrent disease after surgery.

    Authors: Angelo Tozzi, Tiziana Comito, Filippo Alongi, Pierina Navarria, Cristina Iftode, Pietro Mancosu, Giacomo Reggiori, Elena Clerici, Lorenza Rimassa, Alessandro Zerbi, Antonella Fogliata, Luca Cozzi, Stefano Tomatis and Marta Scorsetti

    Citation: Radiation Oncology 2013 8:148

    Content type: Research

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  27. Primary cutaneous follicle center lymphoma is an indolent primary cutaneous B-cell lymphoma originating from the follicle center cells, composed of a combination of centrocytes (small and large cleaved cells) ...

    Authors: Romana Ceovic, Ivana Jovanovic, Kresimir Kostovic, Jaka Rados, Snjezana Dotlic, Ivo Radman, Sandra Marinovic Kulisic and Davorin Loncaric

    Citation: Radiation Oncology 2013 8:147

    Content type: Case report

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  28. In a previous report, we compared the conformity of robust intensity-modulated proton therapy (IMPT) plans with that of helical tomotherapy plans for re-irradiations of head and neck carcinomas using a fixed s...

    Authors: Martin Stuschke, Andreas Kaiser, Jehad Abu Jawad, Christoph Pöttgen, Sabine Levegrün and Jonathan Farr

    Citation: Radiation Oncology 2013 8:145

    Content type: Short report

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  29. To quantify the development of radiation neuropathy in corneal subbasal nerve plexus (SNP) after plaque brachytherapy, and the subsequent regeneration of SNP micromorphology and corneal sensation.

    Authors: Andrey Zhivov, Karsten Winter, Sabine Peschel, Oliver Stachs, Andreas Wree, Guido Hildebrandt and Rudolf Guthoff

    Citation: Radiation Oncology 2013 8:136

    Content type: Research

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  30. Neoadjuvant chemoradiation has become the standard treatment in locally advanced rectal cancer (LARC) and improves local control. This study explored the feasibility of an intensified chemoradiation treatment ...

    Authors: Ji Zhu, Weilie Gu, Peng Lian, Weiqi Sheng, Gang Cai, Debing Shi, Sanjun Cai and Zhen Zhang

    Citation: Radiation Oncology 2013 8:130

    Content type: Research

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  31. Several single institution phase I and phase II trials of stereotactic ablative body radiotherapy (SABR) for liver tumors have reported promising results and high local control rates of over 90%. However, ther...

    Authors: Takahisa Eriguchi, Atsuya Takeda, Yohei Oku, Satoshi Ishikura, Tomoki Kimura, Shuichi Ozawa, Takeo Nakashima, Yukinori Matsuo, Mitsuhiro Nakamura, Yasuo Matsumoto, Sadanori Yamazaki, Naoko Sanuki and Yoshinori Ito

    Citation: Radiation Oncology 2013 8:113

    Content type: Research

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  32. To analyze setup deviations using daily megavoltage computed tomography (MVCT) and to evaluate three MVCT frequency reducing protocols for gynecologic cancer patients treated with helical tomotherapy.

    Authors: Carmen Stromberger, Arne Gruen, Waldemar Wlodarczyk, Volker Budach, Christhardt Koehler and Simone Marnitz

    Citation: Radiation Oncology 2013 8:110

    Content type: Research

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  33. This study investigates the variation in segmentation of several pelvic anatomical structures on computed tomography (CT) between multiple observers and a commercial automatic segmentation method, in the conte...

    Authors: John P Geraghty, Garry Grogan and Martin A Ebert

    Citation: Radiation Oncology 2013 8:106

    Content type: Research

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  34. To test the hypothesis that the therapeutic ratio of intensity-modulated photon therapy using helical tomotherapy (HT) for retreatment of head and neck carcinomas can be improved by robust intensity-modulated ...

    Authors: Martin Stuschke, Andreas Kaiser, Jehad Abu-Jawad, Christoph Pöttgen, Sabine Levegrün and Jonathan Farr

    Citation: Radiation Oncology 2013 8:93

    Content type: Research

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