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  1. Radiotherapy (RT) volumes for anal cancer are large and of moderate complexity when organs at risk (OAR) such as testis, small bowel and bladder are at least partially to be shielded. Volumetric intensity modu...

    Authors: Florian Stieler, Dirk Wolff, Frank Lohr, Volker Steil, Yasser Abo-Madyan, Friedlieb Lorenz, Frederik Wenz and Sabine Mai
    Citation: Radiation Oncology 2009 4:48
  2. Gossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enh...

    Authors: Shuraila F Zerp, Rianne Stoter, Gitta Kuipers, Dajun Yang, Marc E Lippman, Wim J van Blitterswijk, Harry Bartelink, Rogier Rooswinkel, Vincent Lafleur and Marcel Verheij
    Citation: Radiation Oncology 2009 4:47
  3. Alkylphosphocholines represent promising antineoplastic drugs that induce cell death in tumor cells by primary interaction with the cell membrane. Recently we could show that a combination of radiotherapy with...

    Authors: Guido Henke, Lars H Lindner, Michael Vogeser, Hans-Jörg Eibl, Jürgen Wörner, Arndt C Müller, Michael Bamberg, Kirsten Wachholz, Claus Belka and Verena Jendrossek
    Citation: Radiation Oncology 2009 4:46
  4. High grade gliomas (HGG) are typically treated with a combination of surgery, radiotherapy and chemotherapy. Three dimensional (3D) conformal radiotherapy treatment planning is still the main stay of treatment...

    Authors: Leor Zach, Bronwyn Stall, Holly Ning, John Ondos, Barbara Arora, Shankavaram Uma, Robert W Miller, Deborah Citrin and Kevin Camphausen
    Citation: Radiation Oncology 2009 4:45
  5. Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal, but frequently at a cost of treatment rel...

    Authors: Giuseppe Minniti, Maurizio Amichetti and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2009 4:42
  6. Programmed cell death (PCD) is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD). Bcl-2, a c...

    Authors: Andrea Deerberg, Justyna Sosna, Lutz Thon, Claus Belka and Dieter Adam
    Citation: Radiation Oncology 2009 4:41
  7. The availability of alternative sources of information, e. g. the internet, may influence the quantity and quality of information cancer patients receive regarding their disease and treatment. The purpose of t...

    Authors: Johannes Adler, Yvonne Paelecke-Habermann, Patrick Jahn, Margarete Landenberger, Bernd Leplow and Dirk Vordermark
    Citation: Radiation Oncology 2009 4:40
  8. Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distri...

    Authors: Florian Stieler, Hui Yan, Frank Lohr, Frederik Wenz and Fang-Fang Yin
    Citation: Radiation Oncology 2009 4:39
  9. The purpose of this study was to determine the dosimetric effect of on-line position correction for bladder tumor irradiation and to find methods to predict and handle this effect.

    Authors: Dominique C van Rooijen, Jeroen B van de Kamer, René Pool, Maarten CCM Hulshof, Caro CE Koning and Arjan Bel
    Citation: Radiation Oncology 2009 4:38
  10. While IMRT is widely used in treating complex oncological cases in adults, it is not commonly used in pediatric radiation oncology for a variety of reasons. This report evaluates our 9 year experience using st...

    Authors: Florian Sterzing, Eva M Stoiber, Simeon Nill, Harald Bauer, Peter Huber, Jürgen Debus and Marc W Münter
    Citation: Radiation Oncology 2009 4:37
  11. The aim of the study was to evaluate self-assessed bowel toxicity after radiotherapy (RT) for prostate cancer. In contrast to rectal bleeding, information concerning irritative symptoms (rectal urgency, pain) ...

    Authors: Michael Pinkawa, Marc D Piroth, Karin Fischedick, Sandra Nussen, Jens Klotz, Richard Holy and Michael J Eble
    Citation: Radiation Oncology 2009 4:36
  12. When combined with adequate tumoricidal doses, accurate target volume delineation remains to be the one of the most important predictive factors for radiotherapy (RT) success in locally advanced or medically i...

    Authors: Berrin Pehlivan, Erkan Topkan, Cem Onal, Gul Nihal Nursal, Oznur Yuksel, Yemliha Dolek, Melek Nur Yavuz and Ali Aydin Yavuz
    Citation: Radiation Oncology 2009 4:35
  13. A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT.

    Authors: Damien C Weber, Hui Wang, Luca Cozzi, Giovanna Dipasquale, Haleem G Khan, Osman Ratib, Michel Rouzaud, Hansjoerg Vees, Habib Zaidi and Raymond Miralbell
    Citation: Radiation Oncology 2009 4:34
  14. In head and neck cancer, bilateral neck irradiation is the standard approach for many tumor locations and stages. Increasing knowledge on the pattern of nodal invasion leads to more precise targeting and norma...

    Authors: Laura Cerezo, Margarita Martín, Mario López, Alicia Marín and Alberto Gómez
    Citation: Radiation Oncology 2009 4:33
  15. To retrospectively evaluate the results after a regimen of surgery, IORT (intraoperative radiotherapy), and EBRT (external beam radiotherapy) for soft-tissue sarcomas

    Authors: Marcus Niewald, Jochen Fleckenstein, Norbert Licht, Caroline Bleuzen and Christian Ruebe
    Citation: Radiation Oncology 2009 4:32
  16. The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical i...

    Authors: Dane Avondoglio, Tamalee Scott, Whoon Jong Kil, Mary Sproull, Philip J Tofilon and Kevin Camphausen
    Citation: Radiation Oncology 2009 4:31
  17. Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair throu...

    Authors: Pedro C Lara, Marta Lloret, Bernardino Clavo, Rosa M Apolinario, Luis Alberto Henríquez-Hernández, Elisa Bordón, Fausto Fontes and Agustín Rey
    Citation: Radiation Oncology 2009 4:29
  18. Conformal external radiotherapy aims to improve tumor control by boosting tumor dose, reducing morbidity and sparing healthy tissues. To meet this objective careful visualization of the tumor and adjacent area...

    Authors: Chiang J Tyng, Rubens Chojniak, Paula NV Pinto, Marcelle A Borba, Almir GV Bitencourt, Ricardo C Fogaroli, Douglas G Castro and Paulo E Novaes
    Citation: Radiation Oncology 2009 4:28
  19. A study was performed comparing dosimetric characteristics of volumetric modulated arcs (RapidArc, RA) and fixed field intensity modulated therapy (IMRT) on patients with bilateral breast carcinoma.

    Authors: Giorgia Nicolini, Alessandro Clivio, Antonella Fogliata, Eugenio Vanetti and Luca Cozzi
    Citation: Radiation Oncology 2009 4:27
  20. To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer.

    Authors: Peter F Orio III, Gregory S Merrick, Zachariah A Allen, Wayne M Butler, Kent E Wallner, Brian S Kurko and Robert W Galbreath
    Citation: Radiation Oncology 2009 4:26
  21. DCQ (2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide), a synthetic quinoxaline 1,4-dioxide, enhances the cytotoxic effect of ionizing radiation (IR) in vivo and in vitro. We sought to clarify whether incre...

    Authors: Joelle Haykal, Fady Geara, Makhluf J Haddadin, Colin A Smith and Hala Gali-Muhtasib
    Citation: Radiation Oncology 2009 4:25
  22. Despite broad advances in multimodal treatment of locally advanced breast cancer (LABC), 30 to 40% of patients develop loco-regional relapse. The aim of this study was to analyze in a retrospective manner the ...

    Authors: Alberto Alvarado-Miranda, Oscar Arrieta, Carlos Gamboa-Vignolle, David Saavedra-Perez, Rafael Morales-Barrera, Enrique Bargallo-Rocha, Juan Zinser-Sierra, Victor Perez-Sanchez, Teresa Ramirez-Ugalde and Fernando Lara-Medina
    Citation: Radiation Oncology 2009 4:24
  23. Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our random...

    Authors: Susan Li Er Loong, Jacqueline Siok Gek Hwang, Hui Hua Li, Joseph Tien Seng Wee, Swee Peng Yap, Melvin Lee Kiang Chua, Kam Weng Fong and Terence Wee Kiat Tan
    Citation: Radiation Oncology 2009 4:23
  24. To assess the impact of two multileaf collimator (MLC) systems (2.5 and 5 mm leaf widths) on three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and dynamic conformal arc techniques for...

    Authors: James A Tanyi, Paige A Summers, Charles L McCracken, Yiyi Chen, Li-Chung Ku and Martin Fuss
    Citation: Radiation Oncology 2009 4:22
  25. survivors of non-Hodgkin's lymphoma (NHL) are well known to be at an increased risk of second malignancies. In this study, we evaluated the incidence and clinical features of head and neck cancer (HNC) occurri...

    Authors: Kazuma Toda, Hitoshi Shibuya, Keiji Hayashi and Fumio Ayukawa
    Citation: Radiation Oncology 2009 4:21
  26. Extracranial metastases from brain meningiomas is a rare, but well-documented entity. Metastases occur mostly in the lungs, pleura and liver, but may also affect lymph nodes and bones. We report here on a pati...

    Authors: Mirna Abboud, George Haddad, Mireille Kattar, Ibrahim Aburiziq and Fady B Geara
    Citation: Radiation Oncology 2009 4:20
  27. To evaluate the dosimetric differences between Superposition/Convolution (SC) and Monte Carlo (MC) calculated dose distributions for simultaneous integrated boost (SIB) prostate cancer intensity modulated radi...

    Authors: Nesrin Dogan, Ivaylo Mihaylov, Yan Wu, Paul J Keall, Jeffrey V Siebers and Michael P Hagan
    Citation: Radiation Oncology 2009 4:18
  28. Breast cancer patients show a wide variation in normal tissue reactions after radiotherapy. The individual sensitivity to x-rays limits the efficiency of the therapy. Prediction of individual sensitivity to ra...

    Authors: Luis Alberto Henríquez Hernández, Pedro Carlos Lara, Beatriz Pinar, Elisa Bordón, Carlos Rodríguez Gallego, Cristina Bilbao, Leandro Fernández Pérez and Amílcar Flores Morales
    Citation: Radiation Oncology 2009 4:17
  29. The purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial that required on-going RT QA review in t...

    Authors: Naoko Sanuki-Fujimoto, Satoshi Ishikura, Kazushige Hayakawa, Kaoru Kubota, Yutaka Nishiwaki and Tomohide Tamura
    Citation: Radiation Oncology 2009 4:16
  30. In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO2) levels, and prelimin...

    Authors: Fumiya Baba, Yuta Shibamoto, Natsuo Tomita, Chisa Ikeya-Hashizume, Kyota Oda, Shiho Ayakawa, Hiroyuki Ogino and Chikao Sugie
    Citation: Radiation Oncology 2009 4:15
  31. To evaluate the impact of four different rectum contouring techniques and rectal toxicities in patients with treated with 3D conformal radiotherapy (3DCRT).

    Authors: Cem Onal, Erkan Topkan, Esma Efe, Melek Yavuz, Serhat Sonmez and Aydin Yavuz
    Citation: Radiation Oncology 2009 4:14
  32. To evaluate the benefit of an on-line correction protocol based on implanted markers and weekly portal imaging in external beam radiotherapy of prostate cancer. To compare the use of bony anatomy versus implan...

    Authors: Reinhold Graf, Peter Wust, Volker Budach and Dirk Boehmer
    Citation: Radiation Oncology 2009 4:13
  33. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast c...

    Authors: Nabil Ismaili, Nawfel Mellas, Ouafae Masbah, Sanaa Elmajjaoui, Samia Arifi, Imane Bekkouch, Samir Ahid, Zakaria Bazid, Mohammed Adnane Tazi, Abdelouahed Erraki, Omar El Mesbahi, Noureddine Benjaafar, Brahim El Khalil El Gueddari, Mohammed Ismaili, Said Afqir and Hassan Errihani
    Citation: Radiation Oncology 2009 4:12
  34. This retrospective study was done to better understand the conditions for which stereotactic radiosurgery (SRS) for glioblastoma may be efficacious.

    Authors: Tithi Biswas, Paul Okunieff, Michael C Schell, Therese Smudzin, Webster H Pilcher, Robert S Bakos, G Edward Vates, Kevin A Walter, Andrew Wensel, David N Korones and Michael T Milano
    Citation: Radiation Oncology 2009 4:11
  35. The reproducibility of patient setup for radiotherapy is based on various methods including external markers, X-rays with planar or computerized image acquisition, and, more recently, surface matching imaging....

    Authors: Marco Krengli, Simone Gaiano, Eleonora Mones, Andrea Ballarè, Debora Beldì, Cesare Bolchini and Gianfranco Loi
    Citation: Radiation Oncology 2009 4:9
  36. The Script Concordance test (SCT) is a reliable and valid tool to evaluate clinical reasoning in complex situations where experts' opinions may be divided. Scores reflect the degree of concordance between the ...

    Authors: Carole Lambert, Robert Gagnon, David Nguyen and Bernard Charlin
    Citation: Radiation Oncology 2009 4:7
  37. Ongoing changes in cancer care cause an increase in the complexity of cases which is characterized by modern treatment techniques and a higher demand for patient information about the underlying disease and th...

    Authors: Susanne Sehlen, Dirk Vordermark, Christof Schäfer, Peter Herschbach, Anja Bayerl, Steffi Pigorsch, Jutta Rittweger, Claudia Dormin, Tobias Bölling, Hans Joachim Wypior, Franz Zehentmayr, Wolfgang Schulze and Hans Geinitz
    Citation: Radiation Oncology 2009 4:6
  38. Controversy still exists regarding the long-term outcome of patients whose uninvolved lymph node stations are not prophylactically irradiated for non-small cell lung cancer (NSCLC) treated with definitive radi...

    Authors: Erik P Sulman, Ritsuko Komaki, Ann H Klopp, James D Cox and Joe Y Chang
    Citation: Radiation Oncology 2009 4:5
  39. To determine the optimal approach to delineating patient-specific internal gross target volumes (IGTV) from four-dimensional (4-D) computed tomography (CT) image data sets used in the planning of radiation tre...

    Authors: Muthuveni Ezhil, Sastry Vedam, Peter Balter, Bum Choi, Dragan Mirkovic, George Starkschall and Joe Y Chang
    Citation: Radiation Oncology 2009 4:4
  40. This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors – spine tumors, brain tumors abutting the brainstem, and liv...

    Authors: Q Jackie Wu, Zhiheng Wang, John P Kirkpatrick, Zheng Chang, Jeffrey J Meyer, Mei Lu, Calvin Huntzinger and Fang-Fang Yin
    Citation: Radiation Oncology 2009 4:3
  41. A phase III multi-centre randomised trial (ROSEL) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer. Due to rapid changes in radiotherapy tech...

    Authors: Coen W Hurkmans, Johan P Cuijpers, Frank J Lagerwaard, Joachim Widder, Uulke A van der Heide, Danny Schuring and Suresh Senan
    Citation: Radiation Oncology 2009 4:1
  42. To compare morphological gross tumor volumes (GTVs), defined as pre- and postoperative gadolinium enhancement on T1-weighted magnetic resonance imaging to biological tumor volumes (BTVs), defined by the uptake of...

    Authors: Damien C Weber, Thomas Zilli, Franz Buchegger, Nathalie Casanova, Guy Haller, Michel Rouzaud, Philippe Nouet, Giovanna Dipasquale, Osman Ratib, Habib Zaidi, Hansjorg Vees and Raymond Miralbell
    Citation: Radiation Oncology 2008 3:44

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