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  1. Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify...

    Authors: Yusei Fujita, Itsuro Kato, Soichi Iwai, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi and Yoshiaki Yura
    Citation: Radiation Oncology 2009 4:63
  2. To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer.

    Authors: Chen-Hsi Hsieh, Ming-Chow Wei, Hsing-Yi Lee, Sheng-Mou Hsiao, Chien-An Chen, Li-Ying Wang, Yen-Ping Hsieh, Tung-Hu Tsai, Yu-Jen Chen and Pei-Wei Shueng
    Citation: Radiation Oncology 2009 4:62
  3. In locally advanced rectal cancer, 5-Fluorouracil (5-FU)-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties...

    Authors: Adalsteinn Gunnlaugsson, Per Nilsson, Elisabeth Kjellén and Anders Johnsson
    Citation: Radiation Oncology 2009 4:61
  4. Primary orbital lymphoma is a rare disease that accounts for 10% of all orbital tumors. Radiotherapy on the orbital cavity is the treatment of choice for this unusual presentation of localized non-Hodgkin's ly...

    Authors: Luigi De Cicco, Laura Cella, Raffaele Liuzzi, Raffaele Solla, Antonio Farella, Giorgio Punzo, Fausto Tranfa, Diego Strianese, Manuel Conson, Giulio Bonavolontà, Marco Salvatore and Roberto Pacelli
    Citation: Radiation Oncology 2009 4:60
  5. The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understa...

    Authors: Ji-Yoon Kim, Yeon-Sil Kim, Young-Kyoon Kim, Hyun-Jin Park, Seung-Joon Kim, Jin-Hyoung Kang, Young-Pil Wang, Hong-Seok Jang, Sang-Nam Lee and Sei-Chul Yoon
    Citation: Radiation Oncology 2009 4:59
  6. Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation is a limiting factor for treatment success. Determination of lymphocyte radiosensitivity by radio-induced apoptosis aris...

    Authors: Elisa Bordón, Luis Alberto Henríquez Hernández, Pedro C Lara, Beatriz Pinar, Fausto Fontes, Carlos Rodríguez Gallego and Marta Lloret
    Citation: Radiation Oncology 2009 4:58
  7. Biological brain tumor imaging using O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET combined with inverse treatment planning for locally restricted dose escalation in patients with glioblastoma multiforme seems to b...

    Authors: Marc D Piroth, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Cengiz Demirel, Charbel Attieh, Hans J Kaiser, Karl J Langen and Michael J Eble
    Citation: Radiation Oncology 2009 4:57
  8. The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful to improve target volume delineatio...

    Authors: Barbara Gehler, Frank Paulsen, Mehmet Ö Öksüz, Till-Karsten Hauser, Susanne M Eschmann, Roland Bares, Christina Pfannenberg, Michael Bamberg, Peter Bartenstein, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2009 4:56
  9. Reirradiation to the abdomen could potentially play a role in palliation of symptoms or local control in patients with gastrointestinal malignancies. Our goal was to retrospectively determine rates of toxicity...

    Authors: Waqar Haque, Christopher H Crane, Sunil Krishnan, Marc E Delclos, Milind Javle, Christopher R Garrett, Robert A Wolff and Prajnan Das
    Citation: Radiation Oncology 2009 4:55
  10. In the present work we compared the spatial uncertainties associated with a MR-based workflow for external radiotherapy of prostate cancer to a standard CT-based workflow. The MR-based workflow relies on targe...

    Authors: Tufve Nyholm, Morgan Nyberg, Magnus G Karlsson and Mikael Karlsson
    Citation: Radiation Oncology 2009 4:54
  11. To evaluate the functionality of the auditory system in patients who underwent radiotherapy and chemotherapy treatment with cisplatin to treat head and neck tumors.

    Authors: Ana Helena B Dell'Aringa, Myrian L Isaac, Gustavo V Arruda, Maria Carolina BN Esteves, Alfredo Rafael Dell'Aringa, José Luis S Júnior and Alexandre F Rodrigues
    Citation: Radiation Oncology 2009 4:53
  12. To investigate the association between dose to various anatomical structures and dysphagia among patients with head and neck cancer treated by definitive intensity-modulated radiotherapy (IMRT) and concurrent ...

    Authors: Baoqing Li, Dan Li, Derick H Lau, D Gregory Farwell, Quang Luu, David M Rocke, Kathleen Newman, Jean Courquin, James A Purdy and Allen M Chen
    Citation: Radiation Oncology 2009 4:52
  13. Prostate radiotherapy (RT) dose escalation has been reported to result in improved biochemical control at the cost of greater late toxicity. We report on the application of 79.8 Gy in 42 fractions of prostate ...

    Authors: Jarad M Martin, Andrew Bayley, Robert Bristow, Peter Chung, Mary Gospodarowicz, Cynthia Menard, Michael Milosevic, Tara Rosewall, Padraig R Warde and Charles N Catton
    Citation: Radiation Oncology 2009 4:50

    The Erratum to this article has been published in Radiation Oncology 2009 4:65

  14. The combination of ionizing radiation with the pro-apoptotic TRAIL receptor antibody lexatumumab has been shown to exert considerable synergistic apoptotic effects in vitro and in short term growth delay assay...

    Authors: Patrizia Marini, Dorothea Junginger, Stefan Stickl, Wilfried Budach, Maximilian Niyazi and Claus Belka
    Citation: Radiation Oncology 2009 4:49
  15. Radiotherapy (RT) volumes for anal cancer are large and of moderate complexity when organs at risk (OAR) such as testis, small bowel and bladder are at least partially to be shielded. Volumetric intensity modu...

    Authors: Florian Stieler, Dirk Wolff, Frank Lohr, Volker Steil, Yasser Abo-Madyan, Friedlieb Lorenz, Frederik Wenz and Sabine Mai
    Citation: Radiation Oncology 2009 4:48
  16. Gossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enh...

    Authors: Shuraila F Zerp, Rianne Stoter, Gitta Kuipers, Dajun Yang, Marc E Lippman, Wim J van Blitterswijk, Harry Bartelink, Rogier Rooswinkel, Vincent Lafleur and Marcel Verheij
    Citation: Radiation Oncology 2009 4:47
  17. Alkylphosphocholines represent promising antineoplastic drugs that induce cell death in tumor cells by primary interaction with the cell membrane. Recently we could show that a combination of radiotherapy with...

    Authors: Guido Henke, Lars H Lindner, Michael Vogeser, Hans-Jörg Eibl, Jürgen Wörner, Arndt C Müller, Michael Bamberg, Kirsten Wachholz, Claus Belka and Verena Jendrossek
    Citation: Radiation Oncology 2009 4:46
  18. High grade gliomas (HGG) are typically treated with a combination of surgery, radiotherapy and chemotherapy. Three dimensional (3D) conformal radiotherapy treatment planning is still the main stay of treatment...

    Authors: Leor Zach, Bronwyn Stall, Holly Ning, John Ondos, Barbara Arora, Shankavaram Uma, Robert W Miller, Deborah Citrin and Kevin Camphausen
    Citation: Radiation Oncology 2009 4:45
  19. Meningiomas located in the region of the base of skull are difficult to access. Complex combined surgical approaches are more likely to achieve complete tumor removal, but frequently at a cost of treatment rel...

    Authors: Giuseppe Minniti, Maurizio Amichetti and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2009 4:42
  20. Programmed cell death (PCD) is essential for development and homeostasis of multicellular organisms and can occur by caspase-dependent apoptosis or alternatively, by caspase-independent PCD (ciPCD). Bcl-2, a c...

    Authors: Andrea Deerberg, Justyna Sosna, Lutz Thon, Claus Belka and Dieter Adam
    Citation: Radiation Oncology 2009 4:41
  21. The availability of alternative sources of information, e. g. the internet, may influence the quantity and quality of information cancer patients receive regarding their disease and treatment. The purpose of t...

    Authors: Johannes Adler, Yvonne Paelecke-Habermann, Patrick Jahn, Margarete Landenberger, Bernd Leplow and Dirk Vordermark
    Citation: Radiation Oncology 2009 4:40
  22. Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distri...

    Authors: Florian Stieler, Hui Yan, Frank Lohr, Frederik Wenz and Fang-Fang Yin
    Citation: Radiation Oncology 2009 4:39
  23. The purpose of this study was to determine the dosimetric effect of on-line position correction for bladder tumor irradiation and to find methods to predict and handle this effect.

    Authors: Dominique C van Rooijen, Jeroen B van de Kamer, René Pool, Maarten CCM Hulshof, Caro CE Koning and Arjan Bel
    Citation: Radiation Oncology 2009 4:38
  24. While IMRT is widely used in treating complex oncological cases in adults, it is not commonly used in pediatric radiation oncology for a variety of reasons. This report evaluates our 9 year experience using st...

    Authors: Florian Sterzing, Eva M Stoiber, Simeon Nill, Harald Bauer, Peter Huber, Jürgen Debus and Marc W Münter
    Citation: Radiation Oncology 2009 4:37
  25. The aim of the study was to evaluate self-assessed bowel toxicity after radiotherapy (RT) for prostate cancer. In contrast to rectal bleeding, information concerning irritative symptoms (rectal urgency, pain) ...

    Authors: Michael Pinkawa, Marc D Piroth, Karin Fischedick, Sandra Nussen, Jens Klotz, Richard Holy and Michael J Eble
    Citation: Radiation Oncology 2009 4:36
  26. When combined with adequate tumoricidal doses, accurate target volume delineation remains to be the one of the most important predictive factors for radiotherapy (RT) success in locally advanced or medically i...

    Authors: Berrin Pehlivan, Erkan Topkan, Cem Onal, Gul Nihal Nursal, Oznur Yuksel, Yemliha Dolek, Melek Nur Yavuz and Ali Aydin Yavuz
    Citation: Radiation Oncology 2009 4:35
  27. A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT.

    Authors: Damien C Weber, Hui Wang, Luca Cozzi, Giovanna Dipasquale, Haleem G Khan, Osman Ratib, Michel Rouzaud, Hansjoerg Vees, Habib Zaidi and Raymond Miralbell
    Citation: Radiation Oncology 2009 4:34
  28. In head and neck cancer, bilateral neck irradiation is the standard approach for many tumor locations and stages. Increasing knowledge on the pattern of nodal invasion leads to more precise targeting and norma...

    Authors: Laura Cerezo, Margarita Martín, Mario López, Alicia Marín and Alberto Gómez
    Citation: Radiation Oncology 2009 4:33
  29. To retrospectively evaluate the results after a regimen of surgery, IORT (intraoperative radiotherapy), and EBRT (external beam radiotherapy) for soft-tissue sarcomas

    Authors: Marcus Niewald, Jochen Fleckenstein, Norbert Licht, Caroline Bleuzen and Christian Ruebe
    Citation: Radiation Oncology 2009 4:32
  30. The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical i...

    Authors: Dane Avondoglio, Tamalee Scott, Whoon Jong Kil, Mary Sproull, Philip J Tofilon and Kevin Camphausen
    Citation: Radiation Oncology 2009 4:31
  31. Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair throu...

    Authors: Pedro C Lara, Marta Lloret, Bernardino Clavo, Rosa M Apolinario, Luis Alberto Henríquez-Hernández, Elisa Bordón, Fausto Fontes and Agustín Rey
    Citation: Radiation Oncology 2009 4:29
  32. Conformal external radiotherapy aims to improve tumor control by boosting tumor dose, reducing morbidity and sparing healthy tissues. To meet this objective careful visualization of the tumor and adjacent area...

    Authors: Chiang J Tyng, Rubens Chojniak, Paula NV Pinto, Marcelle A Borba, Almir GV Bitencourt, Ricardo C Fogaroli, Douglas G Castro and Paulo E Novaes
    Citation: Radiation Oncology 2009 4:28
  33. A study was performed comparing dosimetric characteristics of volumetric modulated arcs (RapidArc, RA) and fixed field intensity modulated therapy (IMRT) on patients with bilateral breast carcinoma.

    Authors: Giorgia Nicolini, Alessandro Clivio, Antonella Fogliata, Eugenio Vanetti and Luca Cozzi
    Citation: Radiation Oncology 2009 4:27
  34. To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer.

    Authors: Peter F Orio III, Gregory S Merrick, Zachariah A Allen, Wayne M Butler, Kent E Wallner, Brian S Kurko and Robert W Galbreath
    Citation: Radiation Oncology 2009 4:26
  35. DCQ (2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide), a synthetic quinoxaline 1,4-dioxide, enhances the cytotoxic effect of ionizing radiation (IR) in vivo and in vitro. We sought to clarify whether incre...

    Authors: Joelle Haykal, Fady Geara, Makhluf J Haddadin, Colin A Smith and Hala Gali-Muhtasib
    Citation: Radiation Oncology 2009 4:25
  36. Despite broad advances in multimodal treatment of locally advanced breast cancer (LABC), 30 to 40% of patients develop loco-regional relapse. The aim of this study was to analyze in a retrospective manner the ...

    Authors: Alberto Alvarado-Miranda, Oscar Arrieta, Carlos Gamboa-Vignolle, David Saavedra-Perez, Rafael Morales-Barrera, Enrique Bargallo-Rocha, Juan Zinser-Sierra, Victor Perez-Sanchez, Teresa Ramirez-Ugalde and Fernando Lara-Medina
    Citation: Radiation Oncology 2009 4:24
  37. Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our random...

    Authors: Susan Li Er Loong, Jacqueline Siok Gek Hwang, Hui Hua Li, Joseph Tien Seng Wee, Swee Peng Yap, Melvin Lee Kiang Chua, Kam Weng Fong and Terence Wee Kiat Tan
    Citation: Radiation Oncology 2009 4:23
  38. To assess the impact of two multileaf collimator (MLC) systems (2.5 and 5 mm leaf widths) on three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and dynamic conformal arc techniques for...

    Authors: James A Tanyi, Paige A Summers, Charles L McCracken, Yiyi Chen, Li-Chung Ku and Martin Fuss
    Citation: Radiation Oncology 2009 4:22
  39. survivors of non-Hodgkin's lymphoma (NHL) are well known to be at an increased risk of second malignancies. In this study, we evaluated the incidence and clinical features of head and neck cancer (HNC) occurri...

    Authors: Kazuma Toda, Hitoshi Shibuya, Keiji Hayashi and Fumio Ayukawa
    Citation: Radiation Oncology 2009 4:21
  40. Extracranial metastases from brain meningiomas is a rare, but well-documented entity. Metastases occur mostly in the lungs, pleura and liver, but may also affect lymph nodes and bones. We report here on a pati...

    Authors: Mirna Abboud, George Haddad, Mireille Kattar, Ibrahim Aburiziq and Fady B Geara
    Citation: Radiation Oncology 2009 4:20
  41. To evaluate the dosimetric differences between Superposition/Convolution (SC) and Monte Carlo (MC) calculated dose distributions for simultaneous integrated boost (SIB) prostate cancer intensity modulated radi...

    Authors: Nesrin Dogan, Ivaylo Mihaylov, Yan Wu, Paul J Keall, Jeffrey V Siebers and Michael P Hagan
    Citation: Radiation Oncology 2009 4:18
  42. Breast cancer patients show a wide variation in normal tissue reactions after radiotherapy. The individual sensitivity to x-rays limits the efficiency of the therapy. Prediction of individual sensitivity to ra...

    Authors: Luis Alberto Henríquez Hernández, Pedro Carlos Lara, Beatriz Pinar, Elisa Bordón, Carlos Rodríguez Gallego, Cristina Bilbao, Leandro Fernández Pérez and Amílcar Flores Morales
    Citation: Radiation Oncology 2009 4:17
  43. The purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial that required on-going RT QA review in t...

    Authors: Naoko Sanuki-Fujimoto, Satoshi Ishikura, Kazushige Hayakawa, Kaoru Kubota, Yutaka Nishiwaki and Tomohide Tamura
    Citation: Radiation Oncology 2009 4:16
  44. In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO2) levels, and prelimin...

    Authors: Fumiya Baba, Yuta Shibamoto, Natsuo Tomita, Chisa Ikeya-Hashizume, Kyota Oda, Shiho Ayakawa, Hiroyuki Ogino and Chikao Sugie
    Citation: Radiation Oncology 2009 4:15
  45. To evaluate the impact of four different rectum contouring techniques and rectal toxicities in patients with treated with 3D conformal radiotherapy (3DCRT).

    Authors: Cem Onal, Erkan Topkan, Esma Efe, Melek Yavuz, Serhat Sonmez and Aydin Yavuz
    Citation: Radiation Oncology 2009 4:14

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