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  1. The OneDosePlusTM system, based on MOSFET solid-state radiation detectors and a handheld dosimetry reader, has been used to evaluate intra-fraction movements of patients with breast and prostate cancer.

    Authors: Maria Daniela Falco, Marco D’Andrea, Alessia Lo Bosco, Mauro Rebuzzi, Elisabetta Ponti, Barbara Tolu, Grazia Tortorelli, Rosaria Barbarino, Luana Di Murro and Riccardo Santoni
    Citation: Radiation Oncology 2012 7:97
  2. Artemis has a defined role in V(D)J recombination and has been implicated in the repair of radiation induced double-strand breaks. However the exact function(s) of Artemis in DNA repair and its preferred subst...

    Authors: Deepa M Sridharan, Mary K Whalen, Donna Almendrala, Francis A Cucinotta, Misako Kawahara, Steven M Yannone and Janice M Pluth
    Citation: Radiation Oncology 2012 7:96
  3. The optimal initial local treatment for patients with Graves’ ophthalmopathy (GO) is not fully characterized. The purpose of this retrospective study is to describe the clinical outcomes of RT as initial local...

    Authors: Roshan S Prabhu, Lang Liebman, Ted Wojno, Brent Hayek, William A Hall and Ian Crocker
    Citation: Radiation Oncology 2012 7:95
  4. Stereotactic brachytherapy (SBT) has been described in several publications as an effective, minimal invasive and safe highly focal treatment option in selected patients with well circumscribed brain tumors <4...

    Authors: Maximilian I Ruge, Philipp Kickingereder, Stefan Grau, Harald Treuer, Volker Sturm and Juergen Voges
    Citation: Radiation Oncology 2012 7:94
  5. Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive therapy option for inoperable liver oligometastases. Outcome and toxicity were retrospectively evaluated in a single-institution patient cohort ...

    Authors: Judit Boda-Heggemann, Dietmar Dinter, Christel Weiss, Anian Frauenfeld, Kerstin Siebenlist, Ulrike Attenberger, Martine Ottstadt, Frank Schneider, Ralf-Dieter Hofheinz, Frederik Wenz and Frank Lohr
    Citation: Radiation Oncology 2012 7:92
  6. The salivary mucin MUC5B, present in (sero)mucous secretions including submandibular gland (SMG) saliva, plays an important role in the lubrication of the oral mucosa and is thought to be related to the feelin...

    Authors: Tim Dijkema, Chris H J Terhaard, Judith M Roesink, Cornelis P J Raaijmakers, Petra A M van den Keijbus, Henk S Brand and Enno C I Veerman
    Citation: Radiation Oncology 2012 7:91
  7. Adaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan to maintain treatment objectives. This requires regions of interest (ROIs) to be defined ...

    Authors: Nicholas Hardcastle, Wolfgang A Tomé, Donald M Cannon, Charlotte L Brouwer, Paul WH Wittendorp, Nesrin Dogan, Matthias Guckenberger, Stéphane Allaire, Yogish Mallya, Prashant Kumar, Markus Oechsner, Anne Richter, Shiyu Song, Michael Myers, Bülent Polat and Karl Bzdusek
    Citation: Radiation Oncology 2012 7:90
  8. The aim of this study was to compare 64Cu-diacetyl-bis(N4-methylsemicarbazone) (64Cu-ATSM) and 18FDG PET uptake characteristics and 64Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous ca...

    Authors: Anders E Hansen, Annemarie T Kristensen, Jesper T Jørgensen, Fintan J McEvoy, Morten Busk, Albert J van der Kogel, Johan Bussink, Svend A Engelholm and Andreas Kjær
    Citation: Radiation Oncology 2012 7:89
  9. To investigate the prognostic value of survivin expression in pretreatment specimens from patients with anal cancer treated with concurrent 5-FU and mitomycin C-based chemoradiation (CRT).

    Authors: Ingeborg Fraunholz, Claus Rödel, Luitpold Distel, Marget Rave-Fränk, Daniela Kohler, Stefan Falk and Franz Rödel
    Citation: Radiation Oncology 2012 7:88
  10. Radiation proctitis after intensity-modulated radiation therapy (IMRT) differs from that seen after pelvic irradiation in that this adverse event is a result of high-dose radiation to a very small area in the ...

    Authors: Shinya Takemoto, Yuta Shibamoto, Shiho Ayakawa, Aiko Nagai, Akihiro Hayashi, Hiroyuki Ogino, Fumiya Baba, Takeshi Yanagi, Chikao Sugie, Hiromi Kataoka and Mikio Mimura
    Citation: Radiation Oncology 2012 7:87
  11. Radiotherapy (RT) is widely used in the treatment of pancreatic cancer. Currently, recommendation has been given for the delineation of the clinical target volume (CTV) in adjuvant RT. Based on recently review...

    Authors: Luciana Caravatta, Giuseppina Sallustio, Fabio Pacelli, Gilbert DA Padula, Francesco Deodato, Gabriella Macchia, Mariangela Massaccesi, Vincenzo Picardi, Savino Cilla, Alfonso Marinelli, Numa Cellini, Vincenzo Valentini and Alessio G Morganti
    Citation: Radiation Oncology 2012 7:86
  12. The aim of this study was to report the long-term clinical outcomes of patients who received stereotactic body radiotherapy (SBRT) as a boost treatment for head and neck cancer.

    Authors: Dong Soo Lee, Yeon Sil Kim, Jae Seok Cheon, Jin Ho Song, Seok Hyun Son, Ji Sun Jang, Young Nam Kang, Jing Hyoung Kang, So Lyoung Jung, Ie Ryung Yoo and Hong Seok Jang
    Citation: Radiation Oncology 2012 7:85
  13. Except for early stages (T1/2 N0), the prognosis for patients with oral cavity cancer (OCC) is known to be worse than for those with pharyngeal carcinoma. While definitive intensity modulated radiation therapy...

    Authors: Gabriela Studer, Michelle Brown, Marius Bredell, Klaus W Graetz, Gerhard Huber, Claudia Linsenmeier, Yousef Najafi, Oliver Riesterer, Tamara Rordorf, Stephan Schmid and Christoph Glanzmann
    Citation: Radiation Oncology 2012 7:84
  14. Local control appears to be an important treatment aim in patients with limited metastases (oligometastases) of colorectal cancer (CRC). Those patients show a favourable prognosis, if - in addition to the loca...

    Authors: Kathrin Dellas, Thomas Reese, Michael Richter, Dirk Arnold and Jürgen Dunst
    Citation: Radiation Oncology 2012 7:83
  15. Low-risk prostate cancer (PCa) patients have excellent outcomes, with treatment modality often selected by perceived effects on quality of life. Acute urinary symptoms are common during external beam radiother...

    Authors: Jeffrey Vainshtein, Eyad Abu-Isa, Karin B Olson, Michael E Ray, Howard M Sandler, Dan Normolle, Dale W Litzenberg, Kathryn Masi, Charlie Pan and Daniel A Hamstra
    Citation: Radiation Oncology 2012 7:82
  16. To analyze the accuracy and inter-observer variability of image-guidance (IG) using 3D or 4D cone-beam CT (CBCT) technology in stereotactic body radiotherapy (SBRT) for lung tumors.

    Authors: Reinhart A Sweeney, Benedikt Seubert, Silke Stark, Vanessa Homann, Gerd Müller, Michael Flentje and Matthias Guckenberger
    Citation: Radiation Oncology 2012 7:81
  17. TomoBreast is a unicenter, non-blinded randomized trial comparing conventional radiotherapy (CR) vs. hypofractionated Tomotherapy (TT) for post-operative treatment of breast cancer. The purpose of the trial is...

    Authors: Hilde Van Parijs, Geertje Miedema, Vincent Vinh-Hung, Sylvia Verbanck, Nele Adriaenssens, Dirk Kerkhove, Truus Reynders, Daniel Schuermans, Katrien Leysen, Shane Hanon, Guy Van Camp, Walter Vincken, Guy Storme, Dirk Verellen and Mark De Ridder
    Citation: Radiation Oncology 2012 7:80
  18. Stereotactic lung radiotherapy (SLRT) has emerged as a curative treatment for medically inoperable patients with early-stage non-small cell lung cancer (NSCLC) and the use of intensity-modulated radiotherapy (...

    Authors: Jan Seppala, Sami Suilamo, Jarmo Kulmala, Pekka Mali and Heikki Minn
    Citation: Radiation Oncology 2012 7:79
  19. Concurrent radiochemotherapy is a recommended treatment option for patients with locally advanced squamous cell head and neck carcinomas with recent data showing the most significant absolute overall and event...

    Authors: Valentina Krstevska, Igor Stojkovski and Beti Zafirova-Ivanovska
    Citation: Radiation Oncology 2012 7:78
  20. Whole brain radiation therapy (WBRT) is an effective treatment in brain metastases and, when combined with local treatments such as surgery and stereotactic radiosurgery, gives the best brain control. Nonethel...

    Authors: Agnes V Tallet, David Azria, Fabrice Barlesi, Jean-Philippe Spano, Antoine F Carpentier, Antony Gonçalves and Philippe Metellus
    Citation: Radiation Oncology 2012 7:77
  21. Our purpose was to report acute gastrointestinal (GI) and genitourinary (GU) toxicity rates for prostate cancer patients undergoing image-guided intensity modulated radiation therapy (IG-IMRT) with a daily end...

    Authors: Curtiland Deville, Stefan Both, Viet Bui, Wei-Ting Hwang, Kay-See Tan, Mattia Schaer, Zelig Tochner and Neha Vapiwala
    Citation: Radiation Oncology 2012 7:76
  22. Radiotherapy (RT) and androgen-deprivation therapy (ADT) are standard treatments for advanced prostate cancer (PC). Tumor vascularization is recognized as an important physiological feature likely to impact on...

    Authors: Kathrine Røe, Lars TG Mikalsen, Albert J van der Kogel, Johan Bussink, Heidi Lyng, Anne H Ree, Laure Marignol and Dag R Olsen
    Citation: Radiation Oncology 2012 7:75
  23. Local control rates are poor in the treatment of pancreatic cancer. We investigated the role of hypofractionated stereotactic body radiation therapy (SBRT) for salvage or boost treatment after conventional dos...

    Authors: Chris E Lominska, Keith Unger, Nadim M Nasr, Nadim Haddad and Greg Gagnon
    Citation: Radiation Oncology 2012 7:74
  24. The primary objective of this research was to assess the relationship between FPs’ knowledge of palliative radiotherapy (RT) and referral for palliative RT.

    Authors: Robert A Olson, Sonca Lengoc, Scott Tyldesley, John French, Colleen McGahan and Jenny Soo
    Citation: Radiation Oncology 2012 7:73
  25. Earlier, we showed that in cancer cells, AMP-activated kinase (AMPK) participates in a signal transduction pathway involving ATM-AMPK-p53/p21cip1 which is activated by ionizing radiation (IR) to mediate G2-M arre...

    Authors: Yaryna Storozhuk, Toran Sanli, Sarah N Hopmans, Carrie Schultz, Tom Farrell, Jean-Claude Cutz, Gregory R Steinberg, James Wright, Gurmit Singh and Theodoros Tsakiridis
    Citation: Radiation Oncology 2012 7:71
  26. Quantitative analysis of transcriptional regulation of genes is a prerequisite for a better understanding of the molecular mechanisms of action of different radiation qualities such as photon, proton or carbon...

    Authors: Geeta D Sharungbam, Christian Schwager, Sara Chiblak, Stephan Brons, Lynn Hlatky, Thomas Haberer, Jürgen Debus and Amir Abdollahi
    Citation: Radiation Oncology 2012 7:70
  27. Radiation-induced lung injury (RILI) is an important dose-limiting toxicity during thoracic radiotherapy. The purpose of this study is to investigate single photon emission computed tomography (SPECT) perfusio...

    Authors: Dongqing Wang, Jinbo Sun, Jingyu Zhu, Xiaohong Li, Yanbo Zhen and Songtao Sui
    Citation: Radiation Oncology 2012 7:69
  28. To describe a pilot study for a novel preclinical model used to test human tissue-based therapies in the setting of cutaneous radiation injury.

    Authors: Lucas H Rifkin, Strahinja Stojadinovic, Collin H Stewart, Kwang H Song, Michael C Maxted, Marcus H Bell, Natalie S Kashefi, Michael P Speiser, Michel Saint-Cyr, Michael D Story, Rod J Rohrich, Spencer A Brown and Timothy D Solberg
    Citation: Radiation Oncology 2012 7:68
  29. Androgens stimulate the production of hypoxia-inducible factor (HIF1α) and ultimately vascular endothelial growth factor (VEGF-A). Additionally, epithelial growth factor (EGF) mediates HIF1α production. Carbon...

    Authors: Damien C Weber, Jean-Christophe Tille, Christophe Combescure, Jean-François Egger, Mahomet Laouiti, Karim Hammad, Perrine Granger, Laura Rubbia-Brandt and Raymond Miralbell
    Citation: Radiation Oncology 2012 7:66
  30. To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position −509), XPD (codon 751), and XRCC1 (codon 399) with the risk of severe erythema after breast cons...

    Authors: Annette Raabe, Katharina Derda, Sebastian Reuther, Silke Szymczak, Kerstin Borgmann, Ulrike Hoeller, Andreas Ziegler, Cordula Petersen and Ekkehard Dikomey
    Citation: Radiation Oncology 2012 7:65
  31. Cytokines may be elevated in tumor and normal tissues following irradiation. Cytokine expression in these tissues may predict for toxicity or tumor control. The purpose of this pilot study was to determine the...

    Authors: Deborah E Citrin, Ying J Hitchcock, Eun Joo Chung, Jonathan Frandsen, Mary Ellen Urick, William Shield and David Gaffney
    Citation: Radiation Oncology 2012 7:64
  32. Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme involved in the repair of radiation-induced single-strand DNA breaks. PARP inhibitors such as olaparib (KU-0059436, AZD-2281) enhance tumor sensitivity t...

    Authors: Katsutoshi Miura, Koh-ichi Sakata, Masanori Someya, Yoshihisa Matsumoto, Hideki Matsumoto, Akihisa Takahashi and Masato Hareyama
    Citation: Radiation Oncology 2012 7:62
  33. To investigate whether different conditions of DNA structure and radiation treatment could modify heterogeneity of response. Additionally to study variance as a potential parameter of heterogeneity for radiose...

    Authors: Clemens Seidel, Christine Lautenschläger, Jürgen Dunst and Arndt-Christian Müller
    Citation: Radiation Oncology 2012 7:61
  34. Treatment options for oesophageal cancer have changed considerably over the last decades with the introduction of multimodal treatment concepts dominating the progress in the field. However, it remains unclear...

    Authors: Maria C Wolf, Franz Zehentmayr, Michael Schmidt, Dieter Hölzel and Claus Belka
    Citation: Radiation Oncology 2012 7:60
  35. Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive c...

    Authors: Turid Hellevik, Ingvild Pettersen, Vivian Berg, Jan Olof Winberg, Bjørn T Moe, Kristian Bartnes, Ruth H Paulssen, Lill-Tove Busund, Roy Bremnes, Anthony Chalmers and Iñigo Martinez-Zubiaurre
    Citation: Radiation Oncology 2012 7:59
  36. We report on a case of Waldenström’s macroglobulinemia (WM) treated with splenic re-irradiation. To the best of our knowledge this has not been reported before. A 69-year-old Asian female patient with WM recei...

    Authors: Zhou Wei, Yu Yanxia, Xu Ying, Wang Han and Jiang Yuhua
    Citation: Radiation Oncology 2012 7:58
  37. To evaluate efficacy and toxicity clinical in the intensified treatment of locally advanced squamous cell carcinoma of the head and neck (SCCHN) with the combination of chemotherapy, the EGFR antibody cetuxima...

    Authors: Alexandra D Jensen, Jürgen Krauss, Karin Potthoff, Christian Simon, Anna V Nikoghosyan, Karen Lossner, Jürgen Debus and Marc W Münter
    Citation: Radiation Oncology 2012 7:57
  38. Intensity-modulated radiotherapy (IMRT) enables a better conformality to the target while sparing the surrounding normal tissues and potentially allows to increase the dose to the target, if this is precisely ...

    Authors: Marcella Palombarini, Stefano Mengoli, Paola Fantazzini, Cecilia Cadioli, Claudio Degli Esposti and Giovanni Piero Frezza
    Citation: Radiation Oncology 2012 7:56
  39. To assess interfraction translational and rotational setup errors, in patients treated with image-guded hypofractionated stereotactic radiotherapy, immobilized by a thermoplastic mask and a bite-block and posi...

    Authors: Gianluca Ingrosso, Roberto Miceli, Dahlia Fedele, Elisabetta Ponti, Michaela Benassi, Rosaria Barbarino, Luana Di Murro, Emilia Giudice, Federico Santarelli and Riccardo Santoni
    Citation: Radiation Oncology 2012 7:54
  40. Brachytherapy as adjuvant treatment for early-stage breast cancer has become widely available and offers patients an expedited treatment schedule. Given this, many women are electing to undergo brachytherapy i...

    Authors: Daniel J Ferraro, Adam A Garsa, Todd A DeWees, Julie A Margenthaler, Michael Naughton, Rebecca Aft, William E Gillanders, Timothy Eberlein, Melissa A Matesa and Imran Zoberi
    Citation: Radiation Oncology 2012 7:53
  41. Histone deacetylase inhibitors are promising new substances in cancer therapy and have also been shown to sensitize different tumor cells to irradiation (XRT). We explored the effect as well as the radiosensit...

    Authors: Markus Thiemann, Susanne Oertel, Volker Ehemann, Wilko Weichert, Albrecht Stenzinger, Marc Bischof, Klaus-J Weber, Ramon Lopez Perez, Uwe Haberkorn, Andreas E Kulozik, Jürgen Debus, Peter E Huber and Claudia Battmann
    Citation: Radiation Oncology 2012 7:52
  42. To investigate repositioning accuracy in particle radiotherapy in 6 degrees of freedom (DOF) and intensity-modulated radiotherapy (IMRT, 3 DOF) for two immobilization devices (Scotchcast masks vs thermoplastic...

    Authors: Alexandra D Jensen, Marcus Winter, Sabine P Kuhn, Jürgen Debus, Olaf Nairz and Marc W Münter
    Citation: Radiation Oncology 2012 7:51
  43. Stereotactic body radiation therapy (SBRT) is a radiation technique used in patients with oligometastatic lung disease. Lung and chest wall toxicities have been described in the patients but pathological verte...

    Authors: María Esperanza Rodríguez-Ruiz, Iñigo San Miguel, Ignacio Gil-Bazo, Jose Luis Perez-Gracia, Leire Arbea, Marta Moreno-Jimenez and Javier Aristu
    Citation: Radiation Oncology 2012 7:50
  44. The radiation field on most megavoltage radiation therapy units are shown by a light field projected through the collimator by a light source mounted inside the collimator. The light field is traditionally use...

    Authors: Christopher F Njeh, Blas Caroprese and Pushkar Desai
    Citation: Radiation Oncology 2012 7:49
  45. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is activated in tumor cells and promotes tumor cell survival after radiation-induced DNA damage. Because the pathway may not be completely inhibited after b...

    Authors: Emmanouil Fokas, Michio Yoshimura, Remko Prevo, Geoff Higgins, Wolfgang Hackl, Sauveur-Michel Maira, Eric J Bernhard, WGillies McKenna and Ruth J Muschel
    Citation: Radiation Oncology 2012 7:48

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