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  1. The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is...

    Authors: Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko and Mohammad K. Khan

    Citation: Radiation Oncology 2021 16:31

    Content type: Research

    Published on:

  2. Radiation-induced brain injury is a common concern for survivors of adult and pediatric brain cancer. Pre-clinically, rodent models are the standard approach to evaluate mechanisms of injury and test new thera...

    Authors: Ilektra Athanasiadi, Whitney D. Perez, Jeannie M. Plantenga, Yava Jones-Hall and Carlos J. Perez-Torres

    Citation: Radiation Oncology 2021 16:30

    Content type: Methodology

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  3. To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academi...

    Authors: Mark J. Stevens, Simon West, Gregory Gard, Christopher Renaud, David Nevell, Stephanie Roderick and Andrew Le

    Citation: Radiation Oncology 2021 16:29

    Content type: Research

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  4. Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is a current pandemic. We initiated a program of systematic SARS-CoV-2 polymerase chain reaction (PCR) testing in all asymptomatic patients re...

    Authors: Roshan S. Prabhu, Reshika Dhakal, Amy S. Hicks, James McBride, Alicia L. Patrick, Christopher D. Corso, Tomain Murphy, Melissa Thonen, Edward H. Lipford, Derek Raghavan and Stuart H. Burri

    Citation: Radiation Oncology 2021 16:28

    Content type: Research

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  5. Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices...

    Authors: Stefanie Corradini, Maximilian Niyazi, Dirk Verellen, Vincenzo Valentini, Seán Walsh, Anca-L. Grosu, Kirsten Lauber, Amato Giaccia, Kristian Unger, Jürgen Debus, Bradley R. Pieters, Matthias Guckenberger, Suresh Senan, Wilfried Budach, Roland Rad, Julia Mayerle…

    Citation: Radiation Oncology 2021 16:27

    Content type: Review

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  6. Segmentation is a crucial step in treatment planning that directly impacts dose distribution and optimization. The aim of this study was to evaluate the inter-individual variability of common cranial organs at...

    Authors: Guillaume Vogin, Liza Hettal, Clarisse Bartau, Juliette Thariat, Marie-Virginie Claeys, Guillaume Peyraga, Paul Retif, Ulrike Schick, Delphine Antoni, Zsuzsa Bodgal, Frederic Dhermain and Loic Feuvret

    Citation: Radiation Oncology 2021 16:26

    Content type: Research

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  8. This meta-analysis evaluated the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

    Authors: Xiaoyong Xiang, Zhen Ding, Lingling Feng and Ning Li

    Citation: Radiation Oncology 2021 16:24

    Content type: Review

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  9. Radiation therapy and chemoradiation therapy play a major role in the definitive management of esophageal cancer. Survival in esophageal cancer patients is still relatively poor, mostly due to high rates of lo...

    Authors: J. Ristau, M. Thiel, S. Katayama, I. Schlampp, K. Lang, M. F. Häfner, K. Herfarth, J. Debus and S. A. Koerber

    Citation: Radiation Oncology 2021 16:23

    Content type: Research

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  10. For meningiomas, complete resection is recommended as first-line treatment while stereotactic radiosurgery (SRS) is established for meningiomas of smaller size considered inoperable. If the patient´s medical c...

    Authors: Maximilian I. Ruge, Juman Tutunji, Daniel Rueß, Eren Celik, Christian Baues, Harald Treuer, Martin Kocher and Stefan Grau

    Citation: Radiation Oncology 2021 16:22

    Content type: Research

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  11. Most previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and ...

    Authors: Yining Gong, Hongqing Zhuang, Shan Chong, Qianyu Shi, Feng Wei, Zhongjun Liu, Hanqiang Ouyang, Xiaoguang Liu and Liang Jiang

    Citation: Radiation Oncology 2021 16:21

    Content type: Research

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  13. Proton therapy is a promising advancement in radiation oncology especially in terms of reducing normal tissue toxicity, although it is currently expensive and of limited availability. Here we estimated the ind...

    Authors: N. Patrik Brodin, Rafi Kabarriti, Clyde B. Schechter, Mark Pankuch, Vinai Gondi, Shalom Kalnicki, Madhur K. Garg and Wolfgang A. Tomé

    Citation: Radiation Oncology 2021 16:19

    Content type: Research

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  14. To investigate maximum tolerated dose (MTD) of axitinib, a selective vascular endothelial growth factor receptor 1–3 inhibitor, in combination with radiotherapy (RT) for advanced hepatocellular carcinoma (HCC).

    Authors: Kai-Lin Yang, Mau-Shin Chi, Hui-Ling Ko, Yi-Ying Huang, Su-Chen Huang, Yu-Min Lin and Kwan-Hwa Chi

    Citation: Radiation Oncology 2021 16:18

    Content type: Research

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  15. Patients with locally advanced rectal cancer generally have different response rates to preoperative neoadjuvant chemo-radiotherapy. This study investigated the value of the apparent diffusion coefficient (ADC...

    Authors: Mengjing Zhao, Lihao Zhao, Han Yang, Yuxia Duan and Gang Li

    Citation: Radiation Oncology 2021 16:17

    Content type: Research

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  16. The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigat...

    Authors: Qiao-xuan Wang, Rong Zhang, Wei-wei Xiao, Shu Zhang, Ming-biao Wei, Yong-heng Li, Hui Chang, Wei-hao Xie, Li-ren Li, Pei-rong Ding, Gong Chen, Zhi-fan Zeng, Wei-hu Wang, Xiang-bo Wan and Yuan-hong Gao

    Citation: Radiation Oncology 2021 16:16

    Content type: Research

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  17. Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to live...

    Authors: Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo and Wen-Yen Huang

    Citation: Radiation Oncology 2021 16:15

    Content type: Research

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  18. Radiotherapy of gastric mucosa-associated lymphoid tissue (MALT) lymphoma should be delivered to the entire stomach with planning target volume (PTV) that accounts for variations in stomach volume, respiratory...

    Authors: Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Yumiko Kono, Yasuhiro Doi, Yoshiyuki Fukugawa, Takahiro Watakabe, Tadashi Matsumoto, Yudai Kai, Masato Maruyama and Natsuo Oya

    Citation: Radiation Oncology 2021 16:14

    Content type: Research

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  19. Surface-guided radiation therapy can be used to continuously monitor a patient’s surface motions during radiotherapy by a non-irradiating, noninvasive optical surface imaging technique. In this study, machine ...

    Authors: Guangyu Wang, Zhibin Li, Guangjun Li, Guyu Dai, Qing Xiao, Long Bai, Yisong He, Yaxin Liu and Sen Bai

    Citation: Radiation Oncology 2021 16:13

    Content type: Research

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  20. Whole brain radiotherapy (WBRT) can impair patients’ cognitive function. Hippocampal avoidance during WBRT can potentially prevent this side effect. However, manually delineating the target area is time-consum...

    Authors: Kaicheng Pan, Lei Zhao, Song Gu, Yi Tang, Jiahao Wang, Wen Yu, Lucheng Zhu, Qi Feng, Ruipeng Su, Zhiyong Xu, Xiadong Li, Zhongxiang Ding, Xiaolong Fu, Shenglin Ma, Jun Yan, Shigong Kang…

    Citation: Radiation Oncology 2021 16:12

    Content type: Research

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  21. Stereotactic ablative radiation therapy (SABR) is effective in treating inoperable stage I non-small cell lung cancer (NSCLC), but imaging assessment of response after SABR is difficult. This prospective study...

    Authors: Dae-Myoung Yang, David A. Palma, Keith Kwan, Alexander V. Louie, Richard Malthaner, Dalilah Fortin, George B. Rodrigues, Brian P. Yaremko, Joanna Laba, Stewart Gaede, Andrew Warner, Richard Inculet and Ting-Yim Lee

    Citation: Radiation Oncology 2021 16:11

    Content type: Research

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  23. An ever-growing body of evidence has linked the gut microbiome with both the effectiveness and the toxicity of cancer therapies. Radiotherapy is an effective way to treat tumors, although large variations exis...

    Authors: Jing Liu, Chao Liu and Jinbo Yue

    Citation: Radiation Oncology 2021 16:9

    Content type: Review

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  24. This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for the treatment outcomes of patients with oesophageal squamous cell carcino...

    Authors: Chengbing Zeng, Tiantian Zhai, Jianzhou Chen, Longjia Guo, Baotian Huang, Hong Guo, Guozhi Liu, Tingting Zhuang, Weitong Liu, Ting Luo, Yanxuan Wu, Guobo Peng, Derui Li and Chuangzhen Chen

    Citation: Radiation Oncology 2021 16:8

    Content type: Research

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  25. In a palliative situation like metastatic spinal cord compression (MSCC), overall treatment time of radiotherapy should be as short as possible. This study compared 5 × 5 Gy in 1 week to 10 × 3 Gy in 2 weeks i...

    Authors: Dirk Rades, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Darejan Lomidze, Raquel Ciervide, Niels H. Hollaender and Steven E. Schild

    Citation: Radiation Oncology 2021 16:7

    Content type: Short report

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  27. To investigate the potential benefit of cytoreductive radiotherapy (cRT) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving abiraterone.

    Authors: Yang Liu, Wen Long, Zitong Zhang, Lixin Mai, Sijuan Huang, Boji Liu, Wufei Cao, Jianhua Wu, Fangjian Zhou, Yonghong Li and Liru He

    Citation: Radiation Oncology 2021 16:5

    Content type: Research

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  28. Metastasis directed treatment (MDT) is increasingly performed with the attempt to improve outcome in non-small cell lung cancer (NSCLC) patients receiving targeted- or immunotherapy (TT/IT). This study aimed t...

    Authors: Stephanie G. C. Kroeze, Jana Schaule, Corinna Fritz, David Kaul, Oliver Blanck, Klaus H. Kahl, Falk Roeder, Shankar Siva, Joost J. C. Verhoeff, Sonja Adebahr, Markus M. Schymalla, Markus Glatzer, Marcella Szuecs, Michael Geier, Georgios Skazikis, Irina Sackerer…

    Citation: Radiation Oncology 2021 16:4

    Content type: Research

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  29. Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the clos...

    Authors: Dongha Lee, Shohei Komatsu, Kazuki Terashima, Hirochika Toyama, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Kentaro Tai, Masahiro Kido, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki and Takumi Fukumoto

    Citation: Radiation Oncology 2021 16:3

    Content type: Research

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  30. The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of ...

    Authors: Yasuo Kosugi, Terufumi Kawamoto, Masaki Oshima, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Naoto Shikama and Keisuke Sasai

    Citation: Radiation Oncology 2021 16:2

    Content type: Research

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  31. To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose–volume histogram (DVH) parameters.

    Authors: Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-ichi Nibu and Ryohei Sasaki

    Citation: Radiation Oncology 2021 16:1

    Content type: Research

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  32. Current guidelines for the treatment of anaplastic astrocytoma (AA) recommend maximal safe resection followed by radiotherapy and chemotherapy. Despite this multimodal treatment approach, patients have a limit...

    Authors: Helena C. W. Wahner, Malte Träger, Katja Bender, Leonille Schweizer, Julia Onken, Carolin Senger, Felix Ehret, Volker Budach and David Kaul

    Citation: Radiation Oncology 2020 15:282

    Content type: Research

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  33. Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitti...

    Authors: Beat Bojaxhiu, Binaya K. Shrestha, Pascal Luterbacher, Olgun Elicin, Mohamed Shelan, Andrew J. S. Macpherson, Benjamin Heimgartner, Roland Giger, Daniel M. Aebersold and Kathrin Zaugg

    Citation: Radiation Oncology 2020 15:281

    Content type: Research

    Published on:

  34. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…

    Citation: Radiation Oncology 2020 15:280

    Content type: Correction

    Published on:

    The original article was published in Radiation Oncology 2020 15:135

  35. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alfredo Conti, Carolin Senger, Güliz Acker, Anne Kluge, Antonio Pontoriero, Alberto Cacciola, Stefano Pergolizzi, Antonino Germanò, Harun Badakhshi, Markus Kufeld, Franziska Meinert, Phuong Nguyen, Franziska Loebel, Peter Vajkoczy, Volker Budach and David Kaul

    Citation: Radiation Oncology 2020 15:279

    Content type: Correction

    Published on:

    The original article was published in Radiation Oncology 2019 14:201

  36. Patients with locally advanced oropharynx squamous cell carcinoma have suboptimal outcomes with standard chemoradiation. Here, we evaluated toxicity and oncologic outcomes of dose escalation using radiosurgica...

    Authors: Prashant Vempati, Aditya N. Halthore, Sewit Teckie, Zaker Rana, Emile Gogineni, Jeffrey Antone, Honglai Zhang, Mihaela Marrero, Kristin Beadle, Douglas K. Frank, Mohamed Aziz, Doru Paul and Maged Ghaly

    Citation: Radiation Oncology 2020 15:278

    Content type: Research

    Published on:

  37. We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) ...

    Authors: Liwen Zhang, Weiwei Wang, Jiyi Hu, Jiade Lu and Lin Kong

    Citation: Radiation Oncology 2020 15:277

    Content type: Research

    Published on:

  38. Local hypofractionated stereotactic radiotherapy (HFSRT) of the resection cavity is emerging as the standard of care in the treatment of patients with a limited number of brain metastases as it warrants less n...

    Authors: Sophia Scharl, Kerstin A. Kessel, Christian Diehl, Jens Gempt, Bernhard Meyer, Claus Zimmer, Christoph Straube and Stephanie E. Combs

    Citation: Radiation Oncology 2020 15:276

    Content type: Research

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  39. This long-term retrospective analysis aimed to investigate the outcome and toxicity profile of stereotactic brachytherapy (SBT) in selected low-grade gliomas WHO grade II (LGGII) in a large patient series.

    Authors: Juliana Watson, Alexander Romagna, Hendrik Ballhausen, Maximilian Niyazi, Stefanie Lietke, Sebastian Siller, Claus Belka, Niklas Thon and Silke Birgit Nachbichler

    Citation: Radiation Oncology 2020 15:275

    Content type: Research

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  40. Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been ...

    Authors: Daniel Rueß, Vera Weyer, Juman Tutunji, Stefan Grau, Martin Kocher, Mauritius Hoevels, Harald Treuer, Christian Baues and Maximilian I. Ruge

    Citation: Radiation Oncology 2020 15:274

    Content type: Research

    Published on:

  41. An O-ring gantry-type linear accelerator (LINAC) with a 6-MV flattening filter-free (FFF) photon beam, Halcyon, includes a reference beam that contains representative information such as the percent depth dose...

    Authors: Min-Geon Choi, Martin Law, Do-Kun Yoon, Mikoto Tamura, Kenji Matsumoto, Masakazu Otsuka, Moo-Sub Kim, Shih-Kien Djeng, Hajime Monzen and Tae Suk Suh

    Citation: Radiation Oncology 2020 15:273

    Content type: Research

    Published on:

  42. Deep learning-based delineation of organs-at-risk for radiotherapy purposes has been investigated to reduce the time-intensiveness and inter-/intra-observer variability associated with manual delineation. We s...

    Authors: Ward van Rooij, Max Dahele, Hanne Nijhuis, Berend J. Slotman and Wilko F. Verbakel

    Citation: Radiation Oncology 2020 15:272

    Content type: Research

    Published on:

  43. To investigate predictors of cognitive decline after whole brain radiotherapy (WBRT) for brain metastases.

    Authors: Matthew Chan, David Ferguson, Elaine Ni Mhurchu, Ren Yuan, Lovedeep Gondara, Michael McKenzie, Robert Olson, Brian Thiessen, Nafisha Lalani, Roy Ma and Alan Nichol

    Citation: Radiation Oncology 2020 15:271

    Content type: Research

    Published on:

  44. To recommend a cranial border for level IIb in delineating clinical target volumes (CTV) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy and to help reach a consensus on ...

    Authors: Lijun Wang, Shengfu Huang, Lanfang Zhang, Xia He and Yatian Liu

    Citation: Radiation Oncology 2020 15:270

    Content type: Research

    Published on:

  45. Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of seconda...

    Authors: Javier Franco-Pérez, Sergio Montes, Josué Sánchez-Hernández and Paola Ballesteros-Zebadúa

    Citation: Radiation Oncology 2020 15:269

    Content type: Research

    Published on:

  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2020 15:268

    Content type: Correction

    Published on:

    The original article was published in Radiation Oncology 2019 14:240

  47. Metastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced malignancy, which can result in neurologic complications and significant deterioration in overall function and qual...

    Authors: Elysia K. Donovan, Jeffrey Greenspoon, Kara L. Schnarr, Timothy J. Whelan, James R. Wright, Crystal Hann, Anthony Whitton, Tom Chow, Sameer Parpia and Anand Swaminath

    Citation: Radiation Oncology 2020 15:267

    Content type: Study protocol

    Published on:

  48. Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patt...

    Authors: Lucas Basler, Robert Poel, Christina Schröder, Alessandra Bolsi, Antony Lomax, Stephanie Tanadini-Lang, Matthias Guckenberger and Damien C. Weber

    Citation: Radiation Oncology 2020 15:266

    Content type: Research

    Published on:

  49. Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome of cases treated outside clinica...

    Authors: Kumiko Karasawa, Tokuhiko Omatsu, Shintaro Shiba, Daisuke Irie, Masaru Wakatsuki and Shigekazu Fukuda

    Citation: Radiation Oncology 2020 15:265

    Content type: Research

    Published on:

  50. It is important to understand how elderly patients with locally advanced pancreatic carcinoma (LAPC) should be treated, since the number of elderly cancer patients will increase. However, the optimal treatment...

    Authors: Takahiro Iwai, Michio Yoshimura, Ryo Ashida, Yoko Goto, Takahiro Kishi, Satoshi Itasaka, Keiko Shibuya, Masashi Kanai, Toshihiko Masui, Akihisa Fukuda, Hiroyoshi Isoda, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2020 15:264

    Content type: Research

    Published on:

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