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  1. Along with breast-conserving surgery (BCS), adjuvant radiotherapy (RT) of patients with early breast cancer plays a crucial role in the oncologic treatment concept. Conventionally, irradiation is carried out w...

    Authors: Michael Mayinger, Kai Joachim Borm, Constantin Dreher, Hendrik Dapper, Marciana-Nona Duma, Markus Oechsner, Severin Kampfer, Stephanie Elisabeth Combs and Daniel Habermehl

    Citation: Radiation Oncology 2019 14:135

    Content type: Research

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  2. Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is impor...

    Authors: Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams and Karen J. Kirkby

    Citation: Radiation Oncology 2019 14:134

    Content type: Review

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  3. The purpose of this study was to assess compliance with treatment planning in a dummy-run for a multicenter clinical trial involving patients with high-risk postoperative uterine cervical cancer using intensit...

    Authors: Hiroyuki Okamoto, Naoya Murakami, Fumiaki Isohashi, Takahiro Kasamatsu, Yoko Hasumi, Kotaro Iijima, Shie Nishioka, Satoshi Nakamura, Mitsuhiro Nakamura, Teiji Nishio, Hiroshi Igaki, Yuko Nakayama, Jun Itami, Satoshi Ishikura, Yasumasa Nishimura and Takafumi Toita

    Citation: Radiation Oncology 2019 14:133

    Content type: Research

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  4. Various prognostic factors have been suggested in meningioma patients including WHO grading, brain invasion and bone involvement, for instance. Brain invasion was included as an independent criterion in the re...

    Authors: Kerstin Zwirner, Frank Paulsen, Jens Schittenhelm, Irina Gepfner-Tuma, Ghazaleh Tabatabai, Felix Behling, Marco Skardelly, Benjamin Bender, Daniel Zips and Franziska Eckert

    Citation: Radiation Oncology 2019 14:132

    Content type: Research

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  5. To analyze baseline CT/MR-based image features of salivary glands to predict radiation-induced xerostomia 3-months after head-and-neck cancer (HNC) radiotherapy.

    Authors: Khadija Sheikh, Sang Ho Lee, Zhi Cheng, Pranav Lakshminarayanan, Luke Peng, Peijin Han, Todd R. McNutt, Harry Quon and Junghoon Lee

    Citation: Radiation Oncology 2019 14:131

    Content type: Research

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  6. To assess the worst-case robust optimization IMPT plans with setup and range uncertainties and to test the hypothesis that the worst-case robust optimization strategies could cover most possible setup and rang...

    Authors: Zhiyong Yang, Heng Li, Yupeng Li, Yuting Li, Yu Chang, Qin Li, Kunyu Yang, Gang Wu, Narayan Sahoo, Falk Poenisch, Michael Gillin, X. Ronald Zhu and Xiaodong Zhang

    Citation: Radiation Oncology 2019 14:129

    Content type: Research

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  7. Lacking quantitative evaluations of clinicopathological features and the risk factors for loco-regional recurrence (LRR) in gastric cancer after D2 gastrectomy, we aimed to develop a competing risk nomogram to...

    Authors: Shu-Bei Wang, Wei-Xiang Qi, Jia-Yi Chen, Cheng Xu, Youlia M. Kirova, Wei-Guo Cao, Rong Cai, Lu Cao, Min Yan and Gang Cai

    Citation: Radiation Oncology 2019 14:128

    Content type: Research

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  8. The role of local radiotherapy in the treatment of metastatic rhabdomyosarcoma is important. However, with peritoneal dissemination, the application of local therapy is challenging. Although there are few repo...

    Authors: Mariko Kawamura, Kuniyasu Okudaira, Yoshiyuki Itoh, Takeshi Kamomae, Eri Nishikawa, Hideki Muramatsu, Yoshiyuki Takahashi, Kazuki Yokota and Shinji Naganawa

    Citation: Radiation Oncology 2019 14:127

    Content type: Case report

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  9. Online magnetic resonance imaging (MRI)-guided radiotherapy of cervical cancer has the potential to further reduce dose to organs at risk (OAR) as compared to a library of plans (LOP) approach. This study pres...

    Authors: J. Visser, P. de Boer, K. F. Crama, Z. van Kesteren, C. R. N. Rasch, L. J. A. Stalpers and A. Bel

    Citation: Radiation Oncology 2019 14:126

    Content type: Research

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  10. To determine the accuracy of a surface guided radiotherapy (SGRT) system for positioning of breast cancer patients in breath-hold (BH) with respect to cone-beam computed tomography (CBCT). Secondly, to evaluat...

    Authors: Vincent C. Hamming, Christa Visser, Estelle Batin, Leah N. McDermott, Dianne M. Busz, Stefan Both, Johannes A. Langendijk and Nanna M. Sijtsema

    Citation: Radiation Oncology 2019 14:125

    Content type: Research

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  11. Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to...

    Authors: Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling and Andrew Ju

    Citation: Radiation Oncology 2019 14:124

    Content type: Research

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  12. Helium (4He) ion beam therapy provides favorable biophysical characteristics compared to currently administered particle therapies, i.e., reduced lateral scattering and enhanced biological damage to deep-seated t...

    Authors: Stewart Mein, Ivana Dokic, Carmen Klein, Thomas Tessonnier, Till Tobias Böhlen, Guiseppe Magro, Julia Bauer, Alfredo Ferrari, Katia Parodi, Thomas Haberer, Jürgen Debus, Amir Abdollahi and Andrea Mairani

    Citation: Radiation Oncology 2019 14:123

    Content type: Research

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  13. For patients with treatment-naïve carcinoma of the prostate, hypofractionated irradiation becomes more and more popular. Due to the low α/β value of prostate cancer, increased single dose leading to a shortene...

    Authors: Stefan A. Koerber, Sonja Katayama, Anja Sander, Cornelia Jaekel, Matthias F. Haefner, Juergen Debus and Klaus Herfarth

    Citation: Radiation Oncology 2019 14:122

    Content type: Study protocol

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  14. The boost irradiation to the tumor bed following whole-breast irradiation (WBI) reduced the risk of ipsilateral breast tumor recurrence (IBTR). However, in Japan, almost all patients with a margin ≤5 mm receiv...

    Authors: Yuka Ono, Michio Yoshimura, Kimiko Hirata, Chikako Yamauchi, Masakazu Toi, Eiji Suzuki, Masahiro Takada, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2019 14:121

    Content type: Research

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  15. Neoadjuvant chemoradiation or chemotherapy has improved the treatment efficacy of patients with resectable, borderline resectable, and locally advanced pancreatic ductal adenocarcinoma (PDAC). Due to the optim...

    Authors: Qiancheng Hu, Dan Wang, Ye Chen, Xiaofen Li, Peng Cao and Dan Cao

    Citation: Radiation Oncology 2019 14:120

    Content type: Research

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  16. Radiation therapy is a mainstay in the treatment of esophageal cancer (EC) patients, and photon radiotherapy has proved beneficial both in the neoadjuvant and the definitive setting. However, regarding the sti...

    Authors: Sarah Hartfiel, Matthias Häfner, Ramon Lopez Perez, Alexander Rühle, Thuy Trinh, Jürgen Debus, Peter E. Huber and Nils H. Nicolay

    Citation: Radiation Oncology 2019 14:119

    Content type: Research

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  17. Primary adenoid cystic carcinomas (ACCs) of the trachea are rare tumors of the central bronchial system. In patients presenting with unresectable tumors, severe comorbidities, or incomplete surgical resection,...

    Authors: Benjamin A. Högerle, Felix Lasitschka, Thomas Muley, Nina Bougatf, Klaus Herfarth, Sebastian Adeberg, Martin Eichhorn, Jürgen Debus, Hauke Winter, Stefan Rieken and Matthias Uhl

    Citation: Radiation Oncology 2019 14:117

    Content type: Research

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  18. Systemic inflammation plays a critical role in cancer progression and oncologic outcomes in cancer patients. We investigated whether preoperative inflammatory biomarkers, including C-reactive protein (CRP), er...

    Authors: Geumju Park, Si Yeol Song, Jin-Hee Ahn, Wan-lim Kim, Jong-seok Lee, Seong-Yun Jeong, Jae Won Park, Eun Kyung Choi, Wonsik Choi and In-Hye Jung

    Citation: Radiation Oncology 2019 14:116

    Content type: Research

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  19. To investigate the efficacy and toxicity of concurrent radiation therapy (RT) and paclitaxel in the treatment of unresectable locoregionally recurrent breast cancer (RBC) after mastectomy as primary treatment.

    Authors: Gang Cai, Lu Cao, Youlia M. Kirova, Yan Feng and Jia-Yi Chen

    Citation: Radiation Oncology 2019 14:115

    Content type: Research

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  20. Clinical outcomes for patients with pancreatic adenocarcinoma (PAC) remain dismal. Local recurrences, proportions of margin positive surgical resections, and overall survival outcomes remain inferior in PAC th...

    Authors: William A. Hall and Karyn A. Goodman

    Citation: Radiation Oncology 2019 14:114

    Content type: Review

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  21. To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...

    Authors: Shichao Wang, Feng Wen, Pengfei Zhang, Xin Wang and Qiu Li

    Citation: Radiation Oncology 2019 14:113

    Content type: Research

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  22. Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...

    Authors: Elisabetta Parisi, Giovenzio Genestreti, Anna Sarnelli, Giulia Ghigi, Donatella Arpa, Marco Angelo Burgio, Giampaolo Gavelli, Alice Rossi, Emanuela Scarpi, Manuela Monti, Anna Tesei, Rolando Polico and Antonino Romeo

    Citation: Radiation Oncology 2019 14:112

    Content type: Research

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  23. To calculate the individualized fraction regime (IFR) in stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) patients using the uncomplicated tumor control probability (UTCP, P+) function...

    Authors: Jia-Yang Lu, Pei-Xian Lin and Bao-Tian Huang

    Citation: Radiation Oncology 2019 14:111

    Content type: Research

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  24. Incurable inflammatory breast cancer (IBC) patients occasionally suffer from general symptoms such as breast pain, bleeding, ulceration, and discharge, and thus require palliative radiotherapy (RT). Hypofracti...

    Authors: Hoon Sik Choi, Hong Seok Jang, Ki Mun Kang and Byung-ock Choi

    Citation: Radiation Oncology 2019 14:110

    Content type: Research

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  25. The aim of this study was to compare dose-volume histogram (DVH) with dose-mass histogram (DMH) parameters for treatment of left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (F...

    Authors: Markus Oechsner, Mathias Düsberg, Kai Joachim Borm, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma

    Citation: Radiation Oncology 2019 14:109

    Content type: Research

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  26. The purpose of this study is to evaluate the impact of two methods of reporting planned dose distributions on the Gamma analysis pass rates for comparison with measured 2D film dose and simulated delivered 3D ...

    Authors: Yixiu Kang, Jiajian Shen, Wei Liu, Paige A. Taylor, Hunter S. Mehrens, Xiaoning Ding, Yanle Hu, Erik Tryggestad, Sameer R. Keole, Steven E. Schild, William W. Wong, Mirek Fatyga and Martin Bues

    Citation: Radiation Oncology 2019 14:108

    Content type: Methodology

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  27. Consistent results are lacking as regards the comparative effectiveness of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) versus conventional intensity-modulated radiotherapy in pati...

    Authors: Daquan Wang, Nan Bi, Tao Zhang, Zongmei Zhou, Zefen Xiao, Jun Liang, Dongfu Chen, Zhouguang Hui, Jima Lv, Xiaozhen Wang, Xin Wang, Lei Deng, Wenqing Wang, Jingbo Wang, Chunyu Wang, Xiaotong Lu…

    Citation: Radiation Oncology 2019 14:106

    Content type: Research

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  28. Despite recent advances in multimodal treatments, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. The aim of this study was to evaluate the efficacy of moderately hypofractionated si...

    Authors: Liangzhi Zhong, Lu Chen, Shengqing Lv, Qingrui Li, Guangpeng Chen, Wen Luo, Pu Zhou and Guanghui Li

    Citation: Radiation Oncology 2019 14:104

    Content type: Research

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  29. In this dosimetric study, a dedicated planning tool for single isocenter stereotactic radiosurgery for multiple brain metastases using dynamic conformal arc therapy (DCAT) was compared to standard volumetric m...

    Authors: Jan Hofmaier, Raphael Bodensohn, Sylvia Garny, Indrawati Hadi, Daniel F. Fleischmann, Michael Eder, Yavuz Dinc, Michael Reiner, Stefanie Corradini, Katia Parodi, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2019 14:103

    Content type: Research

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  30. Radiation treatment to the regional nodes results in an improvement in survival in breast cancer according to a meta-analysis of randomized trials. However, different volumes were targeted in these studies: br...

    Authors: Jan Haussmann, Wilfried Budach, Balint Tamaskovics, Edwin Bölke, Stefanie Corradini, Freddy-Joel Djiepmo-Njanang, Kai Kammers and Christiane Matuschek

    Citation: Radiation Oncology 2019 14:102

    Content type: Research

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  31. The functional outcome after the treatment of laryngeal cancer is tightly related to the quality of life of affected patients. The aim of this study is to describe the long-term morbidity and functional outcom...

    Authors: Lukas Anschuetz, Mohamed Shelan, Marco Dematté, Adrian D. Schubert, Roland Giger and Olgun Elicin

    Citation: Radiation Oncology 2019 14:101

    Content type: Research

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  32. The data regarding a transposed ovary in intensity-modulated radiotherapy (IMRT) are not sufficient. Here we aim to investigate the adequate dose constraint of ovarian transposition before radiotherapy in cerv...

    Authors: Lina Yin, Saiquan Lu, Jun Zhu, Weiling Zhang and Guihao Ke

    Citation: Radiation Oncology 2019 14:100

    Content type: Research

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  33. Determining the appropriate gross tumor volume is important for irradiation planning in addition to palliative radiation for bone metastases. While irradiation planning is commonly performed using simulation c...

    Authors: Yuki Wada, Akira Anbai, Satoshi Kumagai, Eriko Okuyama, Kento Hatakeyama, Noriko Takagi and Manabu Hashimoto

    Citation: Radiation Oncology 2019 14:98

    Content type: Research

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  34. The aim of this study was to assess the correlations between the levels of blood glucose (BG) and the dose of radiation therapy (RT) to the central gustatory system (GS) in glioblastoma multiforme (GBM) patients.

    Authors: Marciana N. Duma, Nadja I. Oszfolk, Tobias Boeckh-Behrens, Markus Oechsner, Claus Zimmer, Bernhard Meyer, Paul T. Pfluger and Stephanie E. Combs

    Citation: Radiation Oncology 2019 14:97

    Content type: Research

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  35. It is uncertain if whole-pelvic irradiation (WPRT) in addition to dose-escalated prostate bed irradiation (PBRT) improves biochemical progression-free survival (bPFS) after prostatectomy for locally advanced t...

    Authors: Carola Link, Patrick Honeck, Akiko Makabe, Frank Anton Giordano, Christian Bolenz, Joerg Schaefer, Markus Bohrer, Frank Lohr, Frederik Wenz and Daniel Buergy

    Citation: Radiation Oncology 2019 14:96

    Content type: Research

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  36. To assess toxicity and quality-of-life (QOL) after carbon ion radiotherapy (CIRT) at the Shanghai Proton and Heavy Ion Center (SPHIC) and identify clinical factors that correlate with urinary, bowel and sexual...

    Authors: Yafang Zhang, Ping Li, Qi Yu, Shuang Wu, Xue Chen, Qing Zhang and Shen Fu

    Citation: Radiation Oncology 2019 14:94

    Content type: Research

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  37. Liver tumors are subject to motion with respiration, which is typically accounted for by increasing the target volume. The prescription dose is often reduced to keep the mean liver dose under a threshold level...

    Authors: M. Gargett, C. Haddad, A. Kneebone, J. T. Booth and N. Hardcastle

    Citation: Radiation Oncology 2019 14:93

    Content type: Research

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  38. Magnetic Resonance-guided radiotherapy (MRgRT) marks the beginning of a new era. MR is a versatile and suitable imaging modality for radiotherapy, as it enables direct visualization of the tumor and the surrou...

    Authors: S. Corradini, F. Alongi, N. Andratschke, C. Belka, L. Boldrini, F. Cellini, J. Debus, M. Guckenberger, J. Hörner-Rieber, F. J. Lagerwaard, R. Mazzola, M. A. Palacios, M. E. P. Philippens, C. P. J. Raaijmakers, C. H. J. Terhaard, V. Valentini…

    Citation: Radiation Oncology 2019 14:92

    Content type: Review

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  39. Although circular collimator arcs (CCA) and dynamic conformal arcs (DCA) are commonly used linear accelerator-based treatment planning techniques for intracranial stereotactic radiosurgery (SRS) of a small sin...

    Authors: Yongsook C. Lee and Yongbok Kim

    Citation: Radiation Oncology 2019 14:91

    Content type: Research

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  40. To evaluate the practicality of NS-21 cream with regard to its skin-related toxicity in patients with head and neck cancer (HNC) who are undergoing concurrent chemoradiation therapy (CCRT) or radiotherapy (RT).

    Authors: Hsiu-Ling Chou, Pei-Wei Shueng, Li-Jen Liao, Chen-Xiong Hsu, Deng-Yu Kuo, Wu-Chia Lo, Pei-Yu Hou, Li-Ying Wang, San-Fang Chou and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2019 14:90

    Content type: Research

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  41. Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolom...

    Authors: Jeroen Verhoeven, Julie Bolcaen, Valerie De Meulenaere, Ken Kersemans, Benedicte Descamps, Sam Donche, Caroline Van den Broecke, Tom Boterberg, Jean-Pierre Kalala, Karel Deblaere, Christian Vanhove, Filip De Vos and Ingeborg Goethals

    Citation: Radiation Oncology 2019 14:89

    Content type: Research

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  42. Standard radiobiology theory of radiation response assumes a uniform innate radiosensitivity of tumors. However, experimental data show that there is significant intratumoral heterogeneity of radiosensitivity....

    Authors: J. C. L. Alfonso and L. Berk

    Citation: Radiation Oncology 2019 14:88

    Content type: Research

    Published on:

  43. This study set out to evaluate the effect of dose rate on normal tissues (the lung, in particular) and the variation in the treatment efficiency as determined by the monitor unit (MU) and energy applied in Lin...

    Authors: Jaeman Son, Noorie Choi, Jung-in Kim, Jong Min Park, Hong-Gyun Wu, Hyun-Cheol Kang and Chang Heon Choi

    Citation: Radiation Oncology 2019 14:87

    Content type: Research

    Published on:

  44. To investigate the potential impact of fractionation regimes and overall treatment time (OTT) on lymphopenia during definitive radiotherapy (RT) and its associations with patient outcomes in non-small cell lun...

    Authors: Qianqian Zhao, Gang Chen, Luxi Ye, Shiming Shi, Shisuo Du, Zhaochong Zeng and Jian He

    Citation: Radiation Oncology 2019 14:86

    Content type: Research

    Published on:

  45. The prognostic significance of radiation dose to the lung or heart is unknown in esophageal cancer patients receiving neoadjuvant chemoradiotherapy followed by surgery (trimodal therapy). This study aimed to d...

    Authors: Jhen-Bin Lin, Li-Chung Hung, Ching-Yuan Cheng, Yu-An Chien, Chou-Hsien Lee, Chia-Chun Huang, Tsai-Wei Chou, Ming-Huei Ko, Yuan-Chun Lai, Mu-Tai Liu, Tung-Hao Chang, Jie Lee and Yu-Jen Chen

    Citation: Radiation Oncology 2019 14:85

    Content type: Research

    Published on:

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