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  1. Content type: Research

    Interfractional organ position variation might differ for abdominal organs and this could have consequences for defining safety margins. Therefore, the purpose of this study is to quantify interfractional posi...

    Authors: Sophie C. Huijskens, Irma W. E. M. van Dijk, Jorrit Visser, Brian V. Balgobind, D. te Lindert, Coen R. N. Rasch, Tanja Alderliesten and Arjan Bel

    Citation: Radiation Oncology 2018 13:173

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  2. Content type: Research

    To evaluate clinical outcomes of simultaneous integrated boost (SIB) - intensity modulated radiotherapy (RT) in patients with non metastatic anal cancer compared to those of a set of patients treated with 3-di...

    Authors: Pierfrancesco Franco, Berardino De Bari, Francesca Arcadipane, Alexis Lepinoy, Manuela Ceccarelli, Gabriella Furfaro, Massimiliano Mistrangelo, Paola Cassoni, Martina Valgiusti, Alessandro Passardi, Andrea Casadei Gardini, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Andrea Evangelista, Umberto Ricardi…

    Citation: Radiation Oncology 2018 13:172

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  3. Content type: Research

    To investigate the treatment failure pattern and factors influencing locoregional recurrence of esophageal squamous cell carcinoma (ESCC) and examine patient survival with re-irradiation (re-RT) after primary ...

    Authors: Liang Hong, Yun-xia Huang, Qing-yang Zhuang, Xue-qing Zhang, Li-rui Tang, Kai-xin Du, Xiao-yi Lin, Bu-hong Zheng, Shao-li Cai, Jun-xin Wu and Jin-luan Li

    Citation: Radiation Oncology 2018 13:171

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  4. Content type: Research

    Automated treatment planning and/or optimization systems (ATPS) are in the process of broad clinical implementation aiming at reducing inter-planner variability, reducing the planning time allocated for the op...

    Authors: J. Krayenbuehl, M. Zamburlini, S. Ghandour, M. Pachoud, S. Tanadini-Lang, J. Tol, M. Guckenberger and W. F. A. R. Verbakel

    Citation: Radiation Oncology 2018 13:170

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    The Correction to this article has been published in Radiation Oncology 2018 13:225

  5. Content type: Research

    The cranial border of the target volume (TV) in rectal cancer patients treated with neoadjuvant chemoradiation (nCRT) is mostly defined at the level of L5/S1. However, current studies have shown that relapse c...

    Authors: Hendrik Dapper, Markus Oechsner, Stefan Münch, Kai Borm, Jan Peeken, Michael Mayinger, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:169

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  6. Content type: Research

    Daily image-guided radiotherapy (IGRT) can contribute to cover extended body volumes with low radiation dose. The effect of additional imaging dose on secondary cancer development is modelled for a collective ...

    Authors: Yvonne Dzierma, Katharina Mikulla, Patrick Richter, Katharina Bell, Patrick Melchior, Frank Nuesken and Christian Rübe

    Citation: Radiation Oncology 2018 13:168

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  7. Content type: Case report

    Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the cent...

    Authors: Jackson M. May, Mark R. Waddle, Daniel H. Miller, William C. Stross, Tasneem A. Kaleem, Byron C. May, Robert C. Miller, Liuyan Jiang, Gerald W. Strong, Daniel M. Trifiletti, Kaisorn L. Chaichana, Ronald Reimer, Han W. Tun and Jennifer L. Peterson

    Citation: Radiation Oncology 2018 13:167

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  8. Content type: Study protocol

    Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with localized prostate cancer. Promising results in terms of disease control and toxicity have been reported with 4 to 5...

    Authors: Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, Robert Förster, Niccolò Giaj-Levra, Nikolaos Koutsouvelis, Aurelie Bertaut, Michel Zimmermann, Giuseppe Roberto D’Agostino, Filippo Alongi, Matthias Guckenberger and Raymond Miralbell

    Citation: Radiation Oncology 2018 13:166

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    The Correction to this article has been published in Radiation Oncology 2018 13:182

  9. Content type: Research

    Stereotactic Body Radiotherapy (SBRT) is an ablative dose delivery technique which requires the highest levels of precision and accuracy. Modeling dose to a lung treatment volume has remained a complex and cha...

    Authors: Dennis J. Mohatt, Tianjun Ma, David B. Wiant, Naveed M. Islam, Jorge Gomez, Anurag K. Singh and Harish K. Malhotra

    Citation: Radiation Oncology 2018 13:165

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  10. Content type: Research

    A wide application of ultrasound for radiation therapy has been hindered by a few issues such as skin and target deformations due to probe pressure, optical tracking disabilities caused by irregular surfaces a...

    Authors: Heejung Kim, Ah Ram Chang, Sungwoo Cho and Sung-Joon Ye

    Citation: Radiation Oncology 2018 13:164

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  11. Content type: Research

    This study clarified the mechanical performance of volumetric modulated arc therapy (VMAT) plans for prostate cancer generated with a commercial knowledge-based treatment planning (KBP) and whether KBP system ...

    Authors: Mikoto Tamura, Hajime Monzen, Kenji Matsumoto, Kazuki Kubo, Masakazu Otsuka, Masahiro Inada, Hiroshi Doi, Kazuki Ishikawa, Kiyoshi Nakamatsu, Iori Sumida, Hirokazu Mizuno, Do-Kun Yoon and Yasumasa Nishimura

    Citation: Radiation Oncology 2018 13:163

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  12. Content type: Research

    Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validit...

    Authors: Georgia K. B. Halkett, Charles Adam Wigley, Samar M Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie McFadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel and Nigel Spry

    Citation: Radiation Oncology 2018 13:162

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  13. Content type: Short report

    The reporting of adverse effects is an integral aspect of a hospital quality improvement (QI) program with the goal of improving care for current and future patients. We report the results of our experience tr...

    Authors: Varun Chowdhry, Pamela Jangro, Saveli Goldberg, Nolan Gagne, Shelley Chabot, Gary Proulx and Cocav Rauwerdink

    Citation: Radiation Oncology 2018 13:161

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  14. Content type: Research

    Lack of animal model of radiation induced muscle fibrosis, this study aimed to establish such a model by using 90 Gy single dose irradiation to mimic clinical relevance and also to explore the potential post-i...

    Authors: Yue Zhou, Xiaowu Sheng, Feiyan Deng, Hui Wang, Liangfang Shen, Yong Zeng, Qianxi Ni, Shibin Zhan and Xiao Zhou

    Citation: Radiation Oncology 2018 13:160

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  15. Content type: Research

    To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeo...

    Authors: Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock…

    Citation: Radiation Oncology 2018 13:159

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    The Correction to this article has been published in Radiation Oncology 2018 13:183

  16. Content type: Research

    Radiotherapy is one of the standard treatments for cutaneous lymphoma and Total Skin Electrons Beam Irradiation (TSEBI) is generally used to treat diffuse cutaneous lymphoma and some cases of localized disease...

    Authors: Michela Buglione, Luigi Spiazzi, Mauro Urpis, Liliana Baushi, Rossella Avitabile, Nadia Pasinetti, Paolo Borghetti, Luca Triggiani, Sara Pedretti, Federica Saiani, Alfredo Fiume, Diana Greco, Stefano Ciccarelli, Alessia Polonini, Renzo Moretti and Stefano Maria Magrini

    Citation: Radiation Oncology 2018 13:158

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  18. Content type: Research

    The demand for dose verification during treatment has risen with the increasing use of intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in modern radiation therapy. This...

    Authors: So-Yeon Park, Jong Min Park, Jung-in Kim, Sungyoung Lee and Chang Heon Choi

    Citation: Radiation Oncology 2018 13:156

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  19. Content type: Research

    A recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in...

    Authors: Wei Ge, Huilin Xu, Yafei Yan and Dedong Cao

    Citation: Radiation Oncology 2018 13:155

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  20. Content type: Research

    This study aimed to analyse the frequency and clinical relevance of sacral insufficiency fractures (SIFs) after high-dose carbon-ion based irradiation of sacral chordomas.

    Authors: Tilman Bostel, Nils Henrik Nicolay, Thomas Welzel, Thomas Bruckner, Matthias Mattke, Sati Akbaba, Tanja Sprave, Jürgen Debus and Matthias Uhl

    Citation: Radiation Oncology 2018 13:154

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  21. Content type: Research

    In this pooled 2-center series LINAC radiosurgery (SRS) has been applied as a treatment option for a subset of refractory trigeminal neuralgia (TN) patients. This study approached to retrospectively assess the...

    Authors: Ali Rashid, Bogdan Pintea, Thomas M. Kinfe, Gunnar Surber, Klaus Hamm and Jan P. Boström

    Citation: Radiation Oncology 2018 13:153

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  22. Content type: Study protocol

    In an oligometastatic setting, metastasis-directed treatment could render patients disease free, possibly for a protracted interval. Stereotactic ablative radiotherapy (SABR) is one of the treatment modalities...

    Authors: Carole Mercier, Piet Dirix, Paul Meijnders, Peter Vermeulen, Steven Van Laere, Hilde Debois, Philippe Huget and Dirk Verellen

    Citation: Radiation Oncology 2018 13:152

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  23. Content type: Research

    Emerging hypofractionated prostate radiotherapy regimens require solutions for accurate target tracking during beam delivery. The goal of this study is to evaluate the performance of the Clarity ultrasound mon...

    Authors: Bin Han, Mohammad Najafi, David T. Cooper, Martin Lachaine, Rie von Eyben, Steven Hancock and Dimitre Hristov

    Citation: Radiation Oncology 2018 13:151

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  24. Content type: Research

    The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).

    Authors: Mingqiu Chen, Minmin Shen, Yu Lin, Pingping Liu, Xiaohong Liu, Xiqing Li, Anchuan Li, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Benhua Xu, Jianhua Lin, Junqiang Chen and Ye Tian

    Citation: Radiation Oncology 2018 13:150

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  25. Content type: Research

    Patient-specific distortions, particularly near tissue/air interfaces, require assessment for magnetic resonance (MR) only radiation treatment planning (RTP). However, patients are dynamic due to changes in ph...

    Authors: Carri Glide-Hurst, Siamak Nejad-Davarani, Steffen Weiss, Weili Zheng, Indrin J. Chetty and Steffen Renisch

    Citation: Radiation Oncology 2018 13:149

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  26. Content type: Research

    In the era of intensity-modulated radiotherapy (IMRT), the role of additional concurrent chemotherapy (CC) to radiotherapy (RT) after induction chemotherapy (IC) compared to IC followed by RT alone remains unc...

    Authors: Linger Liu, Zhenghua Fei, Mengfeng Chen, Lihao Zhao, Huafang Su, Dianna Gu, Baochai Lin, Xiaona Cai, Lihuai Lu, Mengdan Gao, Xuxue Ye, Xiance Jin and Congying Xie

    Citation: Radiation Oncology 2018 13:148

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  27. Content type: Research

    We aimed to evaluate the toxicity, loco-regional control (LRC) and overall survival (OS) associated with accelerated intensity-modulated radiotherapy (IMRT) for locally advanced lung cancer.

    Authors: Nicolas Jaksic, Enrique Chajon, Julien Bellec, Romain Corre, Charles Ricordel, Bertrand de Latour, Hervé Lena, Ulrike Schick, Renaud de Crevoisier and Joël Castelli

    Citation: Radiation Oncology 2018 13:147

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  28. Content type: Commentary

    For 2018, the American Cancer Society estimated that there would be approximately 1.7 million new diagnoses of cancer and about 609,640 cancer-related deaths in the United States. By 2030 these numbers are ant...

    Authors: Paul Russell Roberts, Ashesh B. Jani, Satyaseelan Packianathan, Ashley Albert, Rahul Bhandari and Srinivasan Vijayakumar

    Citation: Radiation Oncology 2018 13:146

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  29. Content type: Research

    The deformable image registration (DIR) technique has the potential to realize the dose accumulation during radiotherapy. This study will analyze the feasibility of evaluating dose-volume parameters for the he...

    Authors: Ying Tong, Yong Yin, Pinjing Cheng and Guanzhong Gong

    Citation: Radiation Oncology 2018 13:145

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  30. Content type: Research

    The software PRIMO for the Monte Carlo simulation of radiotherapy linacs could potentially act as a independent calculation system to verify the calculations of treatment planning systems. We investigated the ...

    Authors: Marcelino Hermida–López, David Sánchez–Artuñedo and Juan Francisco Calvo–Ortega

    Citation: Radiation Oncology 2018 13:144

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  31. Content type: Research

    We sought to determine the role of abdominal reirradiation for patients presenting with recurrent or new primary gastrointestinal (GI) malignancies. At our institution, we have established a hyperfractionated,...

    Authors: Andrew Hunt, Prajnan Das, Bruce D. Minsky, Eugene J. Koay, Sunil Krishnan, Joseph M. Herman, Cullen Taniguchi, Albert Koong, Grace L. Smith and Emma B. Holliday

    Citation: Radiation Oncology 2018 13:143

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  32. Content type: Case report

    Development of primary lung cancer in donor lung post-lung transplantation is very rare, with few described cases. The safety of stereotactic ablative radiotherapy (SABR) for early-stage lung cancer arising fr...

    Authors: Hanbo Chen, Jussi Tikkanen, R. Gabriel Boldt and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:142

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  33. Content type: Research

    To compare the efficacy of ipsilateral lower neck sparing irradiation (ILNSI) versus ipsilateral lower neck prophylactic irradiation (ILNPI) for unilateral or bilateral neck node-negative nasopharyngeal cancer...

    Authors: Cheng-Long Huang, Cheng Xu, Yuan Zhang, Guan-Qun Zhou, Yan-Ping Mao, Qing Liu, Ying Sun, Jun Ma and Ling-Long Tang

    Citation: Radiation Oncology 2018 13:141

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  34. Content type: Research

    The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal mel...

    Authors: Sati Akbaba, Robert Foerster, Nils Henrik Nicolay, Nathalie Arians, Tilman Bostel, Juergen Debus and Henrik Hauswald

    Citation: Radiation Oncology 2018 13:140

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  35. Content type: Research

    While neoadjuvant chemoradiation therapy (nCRT) with subsequent surgery is the treatment of choice for patients with locally advanced or node-positive squamous cell carcinoma of the esophagus (SCC) suitable fo...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Wilko Weichert, Helmut Friess, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl

    Citation: Radiation Oncology 2018 13:139

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  36. Content type: Research

    Until 50% of patients with renal cancer or melanoma, develop brain metastases during the course of their disease. Stereotactic radiotherapy has become a standard of care for patients with a limited number of b...

    Authors: Paul Lesueur, Justine Lequesne, Victor Barraux, William Kao, Julien Geffrelot, Jean-Michel Grellard, Jean-Louis Habrand, Evelyne Emery, Brigitte Marie, Juliette Thariat and Dinu Stefan

    Citation: Radiation Oncology 2018 13:138

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  37. Content type: Research

    To evaluate the difference of absorbed doses calculated to medium and to water by a Monte Carlo (MC) algorithm based treatment planning system (TPS), and to assess the potential clinical impact to dose prescri...

    Authors: Li Chen, Botian Huang, Xiaoyan Huang, Wufei Cao, Wenzhao Sun and Xiaowu Deng

    Citation: Radiation Oncology 2018 13:137

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  38. Content type: Research

    This study evaluated the safety and efficacy of repeat SBRT for local recurrence of stage I non-small-cell lung cancer (NSCLC) and solitary lung metastasis.

    Authors: Yasutaka Ogawa, Yuta Shibamoto, Chisa Hashizume, Takuhito Kondo, Hiromitsu Iwata, Natsuo Tomita and Hiroyuki Ogino

    Citation: Radiation Oncology 2018 13:136

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  39. Content type: Research

    To evaluate the clinical outcomes of patients treated with 3D conformal Hypo-fractionated, deep Inspiratory breath-hold (DIBH), Partial breast radiotherapy, termed “HIP.” HIP was implemented to merge the schedule...

    Authors: Roman O. Kowalchuk, Kara D. Romano, Daniel M. Trifiletti, Sunil W. Dutta, Timothy N. Showalter and Monica M. Morris

    Citation: Radiation Oncology 2018 13:135

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  40. Content type: Research

    The effect of radiotherapy, in particular the application of different multi-fraction schedules in the management of unstable spinal bone metastases (SBM), is incompletely understood. This study aims to compar...

    Authors: Tanja Sprave, Katharina Hees, Thomas Bruckner, Robert Foerster, Tilman Bostel, Ingmar Schlampp, Rami El Shafie, Nils Henrik Nicolay, Juergen Debus and Harald Rief

    Citation: Radiation Oncology 2018 13:134

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  41. Content type: Research

    Characterise patterns of failure of Temporal Lobe (TL) Glioblastoma (GBM) following treatment with relation to normal temporal lobe anatomy and neural pathways.

    Authors: Dasantha Jayamanne, Helen Wheeler, David Brazier, Allison Newey, Marina Kastelan, Linxin Guo and Michael Back

    Citation: Radiation Oncology 2018 13:133

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  42. Content type: Research

    Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 – WBRT-Mel) evaluates the role of adjuvant whole brain rad...

    Authors: Geoffrey Martinage, Angela M. Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo and Gerald Fogarty

    Citation: Radiation Oncology 2018 13:132

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  43. Content type: Research

    Gene expression of specific therapeutic targets in non-malignant lung tissue might play an important role in optimizing targeted therapies. This study aims to identify different expression patterns of fifteen ...

    Authors: Kobe Reynders, Els Wauters, Matthieu Moisse, Herbert Decaluwé, Paul De Leyn, Stéphanie Peeters, Maarten Lambrecht, Kristiaan Nackaerts, Christophe Dooms, Wim Janssens, Johan Vansteenkiste, Diether Lambrechts and Dirk De Ruysscher

    Citation: Radiation Oncology 2018 13:131

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  44. Content type: Research

    To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated ...

    Authors: Li Ma, Bo Qiu, QiWen Li, Li Chen, Bin Wang, YongHong Hu, MengZhong Liu, Li Zhang, Yan Huang, XiaoWu Deng, YunFei Xia, MaoSheng Lin and Hui Liu

    Citation: Radiation Oncology 2018 13:130

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  45. Content type: Research

    Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended d...

    Authors: Kara D. Romano, Colin Hill, Daniel M. Trifiletti, M. Sean Peach, Bethany J. Horton, Neil Shah, Dylan Campbell, Bruce Libby and Timothy N. Showalter

    Citation: Radiation Oncology 2018 13:129

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  46. Content type: Research

    Intra-fraction motion represents a crucial issue in the era of precise radiotherapy in several settings, including breast irradiation. To date, only few data exist on real-time measured intra-fraction motion i...

    Authors: D. Reitz, G. Carl, S. Schönecker, M. Pazos, P. Freislederer, M. Niyazi, U. Ganswindt, F. Alongi, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2018 13:128

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  47. Content type: Research

    Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer.

    Authors: Yeon Joo Kim, Su Ssan Kim, Si Yeol Song and Eun Kyung Choi

    Citation: Radiation Oncology 2018 13:127

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  48. Content type: Research

    Linac output as a function of field sizes has a phantom and a head scatter component. This last term can be measured in-air with appropriate build-up ensuring a complete electron equilibrium and the absence of...

    Authors: A. Fogliata, A. Stravato, G. Reggiori, S. Tomatis, J. Würfel, M. Scorsetti and L. Cozzi

    Citation: Radiation Oncology 2018 13:126

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  49. Content type: Research

    Better knowledge of the dose-toxicity relationship is essential for safe dose escalation to improve local control in cervical cancer radiotherapy. The conventional dose-toxicity model is based on the dose volu...

    Authors: Jiawei Chen, Haibin Chen, Zichun Zhong, Zhuoyu Wang, Brian Hrycushko, Linghong Zhou, Steve Jiang, Kevin Albuquerque, Xuejun Gu and Xin Zhen

    Citation: Radiation Oncology 2018 13:125

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  50. Content type: Research

    Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the nee...

    Authors: Lucas C. Mendez, Alexander V. Louie, Carolina Moreno, Matt Wronski, Andrew Warner, Eric Leung, Roberto Sakuraba, Juliana K. Helito, Ana Rezende, Icaro T. Carvalho and Eduardo Weltman

    Citation: Radiation Oncology 2018 13:124

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