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  1. Content type: Research

    While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour va...

    Authors: Michael P. Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway and Michael Jameson

    Citation: Radiation Oncology 2018 13:97

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  2. Content type: Research

    A new strategy for making the appropriate choice of the representative optimization parameters in planning processes and accurate selection criteria during Pareto surface navigation for general multicriteria o...

    Authors: Juanqi Wang, Zhi Chen, Weiwei Li, Wei Qian, Xiaosheng Wang and Weigang Hu

    Citation: Radiation Oncology 2018 13:94

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  3. Content type: Research

    To analyse the outcome of elderly patients (≥70 years) with esophageal cancer treated with curative intent radio(chemo)therapy.

    Authors: Franziska Walter, David Böckle, Nina-Sophie Schmidt-Hegemann, Rebecca Köpple, Sabine Gerum, Stefan Boeck, Martin Angele, Claus Belka and Falk Roeder

    Citation: Radiation Oncology 2018 13:93

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  4. Content type: Review

    Prediction of radiobiological response is a major challenge in radiotherapy. Of several radiobiological models, the linear-quadratic (LQ) model has been best validated by experimental and clinical data. Clinic...

    Authors: C. M. van Leeuwen, A. L. Oei, J. Crezee, A. Bel, N. A. P. Franken, L. J. A. Stalpers and H. P. Kok

    Citation: Radiation Oncology 2018 13:96

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  5. Content type: Research

    IMRT provides higher dose conformation to the target and dose sparing to surrounding tissues than 3DCRT. Monte Carlo method in Medical Physics is not a novelty to approach dosimetric problems. A new PENELOPE b...

    Authors: Alessandro Esposito, Sofia Silva, Jorge Oliveira, Joana Lencart and João Santos

    Citation: Radiation Oncology 2018 13:91

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  6. Content type: Review

    68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative i....

    Authors: Sebastian Zschaeck, Fabian Lohaus, Marcus Beck, Gregor Habl, Stephanie Kroeze, Constantinos Zamboglou, Stefan Alexander Koerber, Jürgen Debus, Tobias Hölscher, Peter Wust, Ute Ganswindt, Alexander D. J. Baur, Klaus Zöphel, Nikola Cihoric, Matthias Guckenberger, Stephanie E. Combs…

    Citation: Radiation Oncology 2018 13:90

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  7. Content type: Research

    Resistance to radiotherapy is frequently encountered in patients with glioblastoma multiforme. It is caused at least partially by the high glutathione content in the tumour tissue. Therefore, the administratio...

    Authors: E. Schültke, E. Bräuer-Krisch, H. Blattmann, H. Requardt, J. A. Laissue and G. Hildebrandt

    Citation: Radiation Oncology 2018 13:89

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  8. Content type: Research

    With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor’s generally favorable outc...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:86

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  9. Content type: Research

    The loco regional relapse is frequent in the lung disease. The aim of this study was to evaluate the outcomes of re-irradiation by SBRT in terms of Local Control (LC) and toxicities.

    Authors: Donatella Caivano, Maurizio Valeriani, Sara De Matteis, Paolo Bonome, Ivana Russo, Vitaliana De Sanctis, Giuseppe Minniti and Mattia Falchetto Osti

    Citation: Radiation Oncology 2018 13:87

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  10. Content type: Research

    The role of adjuvant radiotherapy (RT) and setting proper RT target volumes have not been clearly demonstrated for extrahepatic bile duct (EHBD) cancer, due to the rarity of the disease and the lack of randomi...

    Authors: Hoon Sik Choi, Ki Mun Kang, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Tae Gyu Kim and Jin Ho Song

    Citation: Radiation Oncology 2018 13:85

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  11. Content type: Research

    L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high.

    Authors: Hannah M. Laidley, David J. Noble, Gill C. Barnett, Julia R. Forman, Amy M. Bates, Richard J. Benson, Sarah J. Jefferies, Rajesh Jena and Neil G. Burnet

    Citation: Radiation Oncology 2018 13:84

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  12. Content type: Research

    Focal radiation therapy has gained of interest in treatment of patients with primary prostate cancer (PCa). The question of how to define the intraprostatic boost volume is still open. Previous studies showed ...

    Authors: Constantinos Zamboglou, Benedikt Thomann, Khodor Koubar, Peter Bronsert, Tobias Krauss, Hans C. Rischke, Ilias Sachpazidis, Vanessa Drendel, Nasr Salman, Kathrin Reichel, Cordula A. Jilg, Martin Werner, Philipp T. Meyer, Michael Bock, Dimos Baltas and Anca L. Grosu

    Citation: Radiation Oncology 2018 13:81

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  13. Content type: Research

    Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT...

    Authors: Fangjuan Li, Ziyang Zhou, Ailu Wu, Yong Cai, Hongyu Wu, Ming Chen and Shixiong Liang

    Citation: Radiation Oncology 2018 13:82

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  14. Content type: Research

    Concurrent chemo-radiation (CT-RT) is a standard therapy for squamous cell carcinoma of anal canal. Different clinical and biological factors may potentially affect outcome. We investigated the prognostic role...

    Authors: Pierfrancesco Franco, Francesco Montagnani, Francesca Arcadipane, Chiara Casadei, Kalliopi Andrikou, Stefania Martini, Giuseppe Carlo Iorio, Mario Scartozzi, Massimiliano Mistrangelo, Lorenzo Fornaro, Paola Cassoni, Stefano Cascinu, Umberto Ricardi and Andrea Casadei Gardini

    Citation: Radiation Oncology 2018 13:83

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  15. Content type: Research

    To evaluate the effect of pretreatment megavoltage computed tomographic (MVCT) scan methodology on setup verification and adaptive dose calculation in helical TomoTherapy.

    Authors: Jian Zhu, Tong Bai, Jiabing Gu, Ziwen Sun, Yumei Wei, Baosheng Li and Yong Yin

    Citation: Radiation Oncology 2018 13:80

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  16. Content type: Retraction Note

    The authors are retracting this article [1] because the data have already been published in [2] making this a redundant publication. Ghazi Alsbeih, Najla Al-Harbi, Khaled Al-Hadyan, Mohamed Shoukri and Nasser ...

    Authors: Ghazi Alsbeih, Medhat El-Sebaie, Najla Al-Harbi, Khaled Al-Hadyan, Mohamed Shoukri and Nasser Al-Rajhi

    Citation: Radiation Oncology 2018 13:79

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    The original article was published in Radiation Oncology 2013 8:125

  17. Content type: Research

    The principle aim of this study is to incorporate 4DCT ventilation imaging into functional treatment planning that preserves high-functioning lung with both double scattering and scanning beam techniques in pr...

    Authors: Qijie Huang, Salma K. Jabbour, Zhiyan Xiao, Ning Yue, Xiao Wang, Hongbin Cao, Yu Kuang, Yin Zhang and Ke Nie

    Citation: Radiation Oncology 2018 13:78

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  18. Content type: Research

    SBRT is standard therapy for early stage lung cancer. Toxicity in central tumors has been a concern. RTOG 0813 showed that central SBRT is safe and effective. We report our experience with central SBRT.

    Authors: Yasmin Korzets ceder, Eyal Fenig, Aron Popvtzer, Nir Peled, Mordechai R. Kramer, Milton Saute, Dima Bragilovsky, Tzippy Schochat and Aaron M. Allen

    Citation: Radiation Oncology 2018 13:77

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  19. Content type: Research

    Postoperative/adjuvant radiotherapy of advanced gastric cancer involves a large planning target volume (PTV) with multi-concave shapes which presents a challenge for volumetric modulated arc therapy (VMAT) pla...

    Authors: Abdul Wahab M. Sharfo, Florian Stieler, Oskar Kupfer, Ben J. M. Heijmen, Maarten L. P. Dirkx, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann and Daniel Buergy

    Citation: Radiation Oncology 2018 13:74

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  20. Content type: Short Report

    Ataxia Telangiectasia and Rad3 related protein (ATR) is a central mediator of the response to DNA damage that may cause the quiescent resistance of cancer initiating cells to genotoxic radiotherapy. NVP-BEZ235...

    Authors: Guido Fròsina, Aldo Profumo, Daniela Marubbi, Diana Marcello, Jean Louis Ravetti and Antonio Daga

    Citation: Radiation Oncology 2018 13:76

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  21. Content type: Research

    Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or l...

    Authors: Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi and Hideki Nishimura

    Citation: Radiation Oncology 2018 13:75

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  22. Content type: Research

    During therapeutic beam irradiation, an unvisualized three-dimensional (3D) target position should be estimated using an external surrogate with an estimation model. Training periods for the developed model wi...

    Authors: Hiraku Iramina, Mitsuhiro Nakamura, Yusuke Iizuka, Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Mizowaki and Ikuo Kanno

    Citation: Radiation Oncology 2018 13:73

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  23. Content type: Research

    The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursit...

    Authors: Oliver Micke, Eyup Ugrak, Stefan Bartmann, Irenaeus A. Adamietz, Ulrich Schaefer, Rebecca Bueker, Klaus Kisters, M. Heinrich Seegenschmiedt, Khashayar Fakhrian and Ralph Muecke

    Citation: Radiation Oncology 2018 13:71

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  24. Content type: Research

    The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radi...

    Authors: Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe and Keiichi Nakagawa

    Citation: Radiation Oncology 2018 13:70

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  25. Content type: Research

    Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictor...

    Authors: Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang and Guang Li

    Citation: Radiation Oncology 2018 13:69

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  26. Content type: Research

    The purpose of this research was to assess agreement between four rating systems of cosmetic outcome measured in a subset of patients with early breast cancer participating in the randomised TARGIT-A trial. TA...

    Authors: Tammy Corica, Anna K. Nowak, Christobel M. Saunders, Max K. Bulsara, Mandy Taylor, Norman R. Williams, Mohammed Keshtgar, David J. Joseph and Jayant S. Vaidya

    Citation: Radiation Oncology 2018 13:68

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  27. Content type: Case report

    Total skin electron beam therapy (TSEBT) is an effective treatment in mycosis fungoides. Total skin helical tomotherapy (TSHT) may be an alternative to TSEBT and may offer several dosimetric and treatment adva...

    Authors: Eric M. Schaff, Stephen A. Rosenberg, Stephanie J. Olson, Steven P. Howard and Kristin A. Bradley

    Citation: Radiation Oncology 2018 13:67

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  28. Content type: Letter to the Editor

    In regard to our recently published paper entitled “Treatment planning comparison of IMPT, VMAT and 4π radiotherapy for prostate cases”, a question was raised whether “4π” was used appropriately to describe th...

    Authors: Ke Sheng

    Citation: Radiation Oncology 2018 13:66

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    The original article was published in Radiation Oncology 2018 13:63

  29. Content type: Research

    We hypothesized that dominant intraprostatic lesions (DILs) could be depictured by multimodal imaging techniques (MRI and/or PSMA PET/CT) in patients with primary prostate cancer (PCa) and investigated possibl...

    Authors: Constantinos Zamboglou, Christina Marie Klein, Benedikt Thomann, Thomas Franz Fassbender, Hans C. Rischke, Simon Kirste, Karl Henne, Natalja Volegova-Neher, Michael Bock, Mathias Langer, Philipp T. Meyer, Dimos Baltas and Anca L. Grosu

    Citation: Radiation Oncology 2018 13:65

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  30. Content type: Letter to the Editor

    This article describe the three dimensional geometrical incompetency of the term “4π radiotherapy”; frequently used in radiation oncology to establish the superiority (or rather complexity) of particular kind ...

    Authors: Biplab Sarkar

    Citation: Radiation Oncology 2018 13:63

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    The original article was published in Radiation Oncology 2017 12:10

    The Letter to the Editor to this article has been published in Radiation Oncology 2018 13:66

  31. Content type: Research

    To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk...

    Authors: Per Munck af Rosenschold, Michael J. Zelefsky, Aditya P. Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke and Joseph O. Deasy

    Citation: Radiation Oncology 2018 13:64

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  32. Content type: Research

    Intensity-modulated radiotherapy is useful for cervical oesophageal carcinoma (CEC); however, increasing low-dose exposure to the lung may lead to radiation pneumonitis. Nevertheless, an irradiation technique ...

    Authors: Makoto Ito, Hidetoshi Shimizu, Takahiro Aoyama, Hiroyuki Tachibana, Natsuo Tomita, Chiyoko Makita, Yutaro Koide, Daiki Kato, Tsuneo Ishiguchi and Takeshi Kodaira

    Citation: Radiation Oncology 2018 13:62

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  33. Content type: Research

    Rectal cancer patients that show a pathological complete response (pCR) after neo-adjuvant chemo-radiotherapy, have better prognosis. To increase pCR rates several studies escalate the tumor irradiation dose. ...

    Authors: Jean-Paul J. E. Kleijnen, Bram van Asselen, Martijn Intven, Johannes P. M. Burbach, Marielle E. P. Philippens, Jan J. W. Lagendijk and Bas W. Raaymakers

    Citation: Radiation Oncology 2018 13:61

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  34. Content type: Methodology

    For a given prescribed dose of radiotherapy, with the successive generations of dose calculation algorithms, more monitor units (MUs) are generally needed. This is due to the implementation of successive impro...

    Authors: Abdulhamid Chaikh, Jarkko Ojala, Catherine Khamphan, Robin Garcia, Jean Yves Giraud, Juliette Thariat and Jacques Balosso

    Citation: Radiation Oncology 2018 13:60

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  35. Content type: Research

    To analyze the respiratory-induced motion of each liver segment using helical computed tomography (helical CT) and 4-dimensional computed tomography (4DCT), and to establish the individual segment expansion ma...

    Authors: Yu-Lun Tsai, Ching-Jung Wu, Suzun Shaw, Pei-Chieh Yu, Hsin-Hua Nien and Louis Tak Lui

    Citation: Radiation Oncology 2018 13:59

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  36. Content type: Research

    Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial ...

    Authors: Donna H. Murrell, Joanna M. Laba, Abigail Erickson, Barbara Millman, David A. Palma and Alexander V. Louie

    Citation: Radiation Oncology 2018 13:57

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  37. Content type: Research

    To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons.

    Authors: Falk Stade, Jan-Oliver Dittmar, Oliver Jäkel, Clemens Kratochwil, Uwe Haberkorn, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:58

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  38. Content type: Research

    Meningiomas of the skull base account for 25–30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantia...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs

    Citation: Radiation Oncology 2018 13:54

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  39. Content type: Research

    We aimed to explore the efficacy and safety profile of preoperative neoadjuvant chemoradiation (NACRT) in locally advanced rectal cancer (LARC) in upper rectum versus middle/lower rectum.

    Authors: Ming-Yii Huang, Hsin-Hua Lee, Hsiang-Lin Tsai, Ching-Wen Huang, Yung-Sung Yeh, Cheng-Jen Ma, Chun-Ming Huang, Chiao-Yun Chen, Joh-Jong Huang and Jaw-Yuan Wang

    Citation: Radiation Oncology 2018 13:53

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  40. Content type: Methodology

    Peer review, especially prospective peer review, has been supported by professional organizations as an important element in optimal Radiation Oncology practice based on its demonstration of efficacy at detect...

    Authors: W Neil Duggar, Rahul Bhandari, Chunli Claus Yang and Srinivasan Vijayakumar

    Citation: Radiation Oncology 2018 13:55

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  41. Content type: Study protocol

    Radiotherapy (RT) delivered in deep inspiration breath-hold (DIBH) is a simple technique, in which changes in patient anatomy can significantly reduce the irradiation of the organs at risk (OARs) surrounding t...

    Authors: Anni Young Lundgaard, Lisa Lyngsie Hjalgrim, Laura Ann Rechner, Mirjana Josipovic, Morten Joergensen, Marianne Camille Aznar, Anne Kill Berthelsen, Lise Borgwardt, Christoffer Johansen, Annika Loft, Akmal Safwat, Leila Vaalavirta, Lena Specht and Maja Vestmoe Maraldo

    Citation: Radiation Oncology 2018 13:56

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  42. Content type: Research

    The purpose of this work is to benchmark RapidPlan against clinical plans for liver Intensity-modulated radiotherapy (IMRT) treatment of patients with special anatomical characteristics, and to investigate the...

    Authors: Gang Yu, Yang Li, Ziwei Feng, Cheng Tao, Zuyi Yu, Baosheng Li and Dengwang Li

    Citation: Radiation Oncology 2018 13:52

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  43. Content type: Research

    To simplify the adaptive treatment planning workflow while achieving the optimal tumor-dose coverage in pancreatic cancer patients undergoing daily adaptive magnetic resonance image guided radiation therapy (M...

    Authors: Sven Olberg, Olga Green, Bin Cai, Deshan Yang, Vivian Rodriguez, Hao Zhang, Jin Sung Kim, Parag J. Parikh, Sasa Mutic and Justin C. Park

    Citation: Radiation Oncology 2018 13:51

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  44. Content type: Correction

    In the original publication [1] one author name was spelled incorrect.

    Authors: Sophie Espenel, Max-Adrien Garcia, Jane-Chloé Trone, Elodie Guillaume, Annabelle Harris, Amel Rehailia-Blanchard, Ming Yuan He, Sarra Ouni, Alexis Vallard, Chloé Rancoule, Majed Ben Mrad, Céline Chauleur, Guy De Laroche, Jean-Baptiste Guy, Pablo Moreno-Acosta and Nicolas Magné

    Citation: Radiation Oncology 2018 13:50

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    The original article was published in Radiation Oncology 2018 13:16

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