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  1. There is a lack of consensus concerning the definition of re-irradiation and re-irradiation volumes in head and neck cancer (HNC). The aim of the present study is to introduce a more strict definition of the r...

    Authors: Anna Embring, Eva Onjukka, Claes Mercke, Ingmar Lax, Anders Berglund, Sara Bornedal, Berit Wennberg and Signe Friesland

    Citation: Radiation Oncology 2020 15:147

    Content type: Research

    Published on:

  2. At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide 125I seed implantation f...

    Authors: Xiangmeng He, Ming Liu, Menglong Zhang, Roberto Blanco Sequeiros, Yujun Xu, Ligang Wang, Chao Liu, Qingwen Wang, Kai Zhang and Chengli Li

    Citation: Radiation Oncology 2020 15:146

    Content type: Research

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  3. Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been test...

    Authors: Jane-Chloe Trone, Alexis Vallard, Sandrine Sotton, Majed Ben Mrad, Omar Jmour, Nicolas Magné, Benjamin Pommier, Silvy Laporte and Edouard Ollier

    Citation: Radiation Oncology 2020 15:145

    Content type: Review

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  5. Desmoid-type fibromatosis is a rare, potentially locally aggressive disease. Herein we present our experience in the treatment with radiotherapy.

    Authors: K. Seidensaal, S. B. Harrabi, F. Weykamp, K. Herfarth, T. Welzel, G. Mechtersheimer, B. Lehner, M. Schneider, S. Fröhling, G. Egerer, J. Debus and M. Uhl

    Citation: Radiation Oncology 2020 15:143

    Content type: Research

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  6. Radiation-induced choanal stenosis (RICS) severely decreases life quality of patients with nasopharyngeal carcinoma (NPC) and originates from nasal mucositis, which depends on radiation dose. This self-control...

    Authors: Hui Chang, Kai Chen, Ya-lan Tao, Fei Han, Wei-jun Ye and Yuan-hong Gao

    Citation: Radiation Oncology 2020 15:142

    Content type: Research

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  8. To examine, if a shift in indications for radiotherapy is to be expected in the context of the COVID-19 pandemic, the database Pubmed was searched for multidisciplinary or surgical expert recommendations on th...

    Authors: Dirk Vordermark

    Citation: Radiation Oncology 2020 15:140

    Content type: Short report

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  9. Immunotherapy has paved the way for new therapeutic opportunities in cancer but has failed to show any efficacy in Pancreatic Adenocarcinoma (PDAC), and its therapeutic role remains unclear. The objective of t...

    Authors: Saber Amin, Michael Baine, Jane Meza, Morshed Alam and Chi Lin

    Citation: Radiation Oncology 2020 15:139

    Content type: Research

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  10. Developments in the field of proton beam therapy (PBT) have recently crossed the tipping point wherein the modality is now more versatile than ever before, with possibilities and likely indications expanding r...

    Authors: Srinivas Chilukuri, Pankaj Kumar Panda and Rakesh Jalali

    Citation: Radiation Oncology 2020 15:138

    Content type: Commentary

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  11. Circulating tumor cells (CTCs) are an established prognostic marker in castration-resistant prostate cancer but have received little attention in localized high-risk disease. We studied the detection rate of C...

    Authors: Almudena Zapatero, Antonio Gómez-Caamaño, María Ángeles Cabeza Rodriguez, Laura Muinelo-Romay, Carmen Martin de Vidales, Alicia Abalo, Patricia Calvo Crespo, Luis Leon Mateos, Carlos Olivier and Lorena Vega Vega Piris

    Citation: Radiation Oncology 2020 15:137

    Content type: Research

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  12. To validate the Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast cancer nodal clinical target volumes (CTVs) and to investigate the Radiotherapy Compara...

    Authors: Laura Beaton, Luminita Nica, Scott Tyldesley, Kenny Sek, Gareth Ayre, Maria Aparicio, Lovedeep Gondara, Caroline Speers and Alan Nichol

    Citation: Radiation Oncology 2020 15:136

    Content type: Research

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  13. Melanoma patients frequently develop brain metastases. The most widely used score to predict survival is the molGPA based on a mixed treatment of stereotactic radiotherapy (SRT) and whole brain radiotherapy (W...

    Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…

    Citation: Radiation Oncology 2020 15:135

    Content type: Research

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    The Correction to this article has been published in Radiation Oncology 2020 15:280

  14. Fatigue is one of the most common and distressing side-effects of breast cancer radiotherapy. According to current guidelines, accelerated partial breast irradiation (APBI) may be considered as an alternative ...

    Authors: Tobias Forster, Cornelia Jäkel, Sati Akbaba, David Krug, Robert Krempien, Matthias Uhl, Matthias Felix Häfner, Laila König, Stefan Alexander Koerber, Semi Harrabi, Denise Bernhardt, Rouven Behnisch, Johannes Krisam, Andre Hennigs, Christof Sohn, Jörg Heil…

    Citation: Radiation Oncology 2020 15:134

    Content type: Study protocol

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  15. Endoscopic resection is widely used as an effective treatment for superficial esophageal cancer. However, the risk of lymph node metastasis increases in cases of muscularis mucosae or deeper invasion, for whic...

    Authors: Ikuno Nishibuchi, Yuji Murakami, Yoshinori Adachi, Nobuki Imano, Yuki Takeuchi, Ippei Tkahashi, Tomoki Kimura, Yuji Urabe, Shiro Oka, Shinji Tanaka and Yasushi Nagata

    Citation: Radiation Oncology 2020 15:133

    Content type: Research

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  16. The evaluation of circulating tumour DNA (ctDNA) from clinical blood samples, liquid biopsy, offers several diagnostic advantages compared with traditional tissue biopsy, such as shorter processing time, reduc...

    Authors: G. M. Walls, L. McConnell, J. McAleese, P. Murray, T. B. Lynch, K. Savage, G. G. Hanna and D. Gonzalez de Castro

    Citation: Radiation Oncology 2020 15:132

    Content type: Research

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  17. Radiosensitivity is limited in cervical cancer (CC) patients due to acquired radiation resistance. In our previous studies, we found that immediate-early response 5 (IER5) is upregulated in CC cells upon radia...

    Authors: Jing-Jie Zheng, Yue He, Yang Liu, Feng-Shuang Li, Zhen Cui, Xiao-Meng Du, Chun-Peng Wang and Yu-Mei Wu

    Citation: Radiation Oncology 2020 15:131

    Content type: Research

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  18. PTV concept is presumed to introduce excessive and inconsistent GTV dose in lung stereotactic body radiotherapy (SBRT). That GTV median dose prescription (D50) and robust optimization are viable PTV–free solution...

    Authors: Ronnie Wing King Leung, Mark Ka Heng Chan, Chi-Leung Chiang, Matthew Wong and Oliver Blanck

    Citation: Radiation Oncology 2020 15:130

    Content type: Research

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  19. The targeting accuracy of proton therapy (PT) for moving soft-tissue tumours is expected to greatly improve by real-time magnetic resonance imaging (MRI) guidance. The integration of MRI and PT at the treatmen...

    Authors: Aswin Hoffmann, Bradley Oborn, Maryam Moteabbed, Susu Yan, Thomas Bortfeld, Antje Knopf, Herman Fuchs, Dietmar Georg, Joao Seco, Maria Francesca Spadea, Oliver Jäkel, Christopher Kurz and Katia Parodi

    Citation: Radiation Oncology 2020 15:129

    Content type: Review

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  20. Hypofractionated-SRS (HF-SRS) may allow for improved local control and a reduced risk of radiation necrosis compared to single-fraction-SRS (SF-SRS). However, data comparing these two treatment approaches are ...

    Authors: Jill S. Remick, Emily Kowalski, Rahul Khairnar, Kai Sun, Emily Morse, Hua-Ren R. Cherng, Yannick Poirier, Narottam Lamichhane, Stewart J. Becker, Shifeng Chen, Akshar N. Patel, Young Kwok, Elizabeth Nichols, Pranshu Mohindra, Graeme F. Woodworth, William F. Regine…

    Citation: Radiation Oncology 2020 15:128

    Content type: Research

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  21. Carbon-ion radiotherapy (CIRT) for prostate cancer was initiated at Kanagawa Cancer Center in 2015. The present study analyzed the preliminary clinical outcomes of CIRT for prostate cancer.

    Authors: Yosuke Takakusagi, Hiroyuki Katoh, Kio Kano, Wataru Anno, Keisuke Tsuchida, Nobutaka Mizoguchi, Itsuko Serizawa, Daisaku Yoshida and Tadashi Kamada

    Citation: Radiation Oncology 2020 15:127

    Content type: Research

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  22. To evaluate the impact of primary tumor radiotherapy on survival in patients with unresectable metastatic rectal or rectosigmoid cancer.

    Authors: Gang Wang, Wenling Wang, Haijie Jin, Hongmin Dong, Weiwei Chen, Xiaokai Li, Guodong Li and Leilei Li

    Citation: Radiation Oncology 2020 15:126

    Content type: Research

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  23. Anal cancer is a rare disease, which might be the reason for the “one size fits all” approach still used for radiotherapy target contouring. To refine and individualize future guidelines, detailed and contempo...

    Authors: Martin P. Nilsson, Erik D. Nilsson, Anders Johnsson, Otilia Leon, Adalsteinn Gunnlaugsson and Jonas Scherman

    Citation: Radiation Oncology 2020 15:125

    Content type: Research

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  24. To investigate the loco-regional progression-free survival (LPFS) of intensity-modulated radiotherapy (IMRT) with different fraction sizes for locally advanced non-small-cell lung cancer (LANSCLC), and to appl...

    Authors: Bo Qiu, Qi Wen Li, Xin Lei Ai, Bin Wang, Jian Huan, Zheng Fei Zhu, Gen Hua Yu, Ming Ji, Hai Hang Jiang, Cheng Li, Jun Zhang, Li Chen, Jin Yu Guo, Yin Zhou and Hui Liu

    Citation: Radiation Oncology 2020 15:124

    Content type: Research

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  25. To review a single institutional experience of the Radiation Therapy Oncology Group (RTOG) 8502 “QUAD shot” regimen using volumetric modulated arc radiotherapy (VMAT) for incurable head and neck cancer (HNC).

    Authors: Ryo Toya, Tetsuo Saito, Kohsei Yamaguchi, Tomohiko Matsuyama, Takahiro Watakabe, Tadashi Matsumoto, Ryoji Yoshida, Akiyuki Hirosue, Daizo Murakami, Yorihisa Orita, Hideki Nakayama and Natsuo Oya

    Citation: Radiation Oncology 2020 15:123

    Content type: Research

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  27. Patients with left-sided breast cancer frequently receive deep inspiration breath-hold (DIBH) radiotherapy to reduce the risk of cardiac side effects. The aim of the present study was to analyze intra-breath-h...

    Authors: D. Reitz, F. Walter, S. Schönecker, P. Freislederer, M. Pazos, M. Niyazi, G. Landry, F. Alongi, E. Bölke, C. Matuschek, M. Reiner, C. Belka and S. Corradini

    Citation: Radiation Oncology 2020 15:121

    Content type: Research

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  28. To investigate the role of intensity-modulated proton therapy (IMPT) compared to volumetric modulated arc therapy (VMAT), realised with RapidArc and RapidPlan methods (RA_RP) for neoadjuvant radiotherapy in lo...

    Authors: Eren Celik, Wolfgang Baus, Christian Baues, Wolfgang Schröder, Alessandro Clivio, Antonella Fogliata, Marta Scorsetti, Simone Marnitz and Luca Cozzi

    Citation: Radiation Oncology 2020 15:120

    Content type: Research

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  29. After esophagectomy, adjuvant chemotherapy (S + CT) and adjuvant chemoradiotherapy (S + CRT) can improve survival in patients with node-positive resectable esophageal cancer. However, we are not aware of any s...

    Authors: Qifeng Wang, Jinyi Lang, Tao Li, Lin Peng, Wei Dai, Yinchun Jiang, Tianpeng Xie, Qiang Fang, Yi Wang, Lei Wu, Bangrong Cao and Yongtao Han

    Citation: Radiation Oncology 2020 15:119

    Content type: Research

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  30. Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. Surgical resection is the standard treatment for localized ACC, but the local recurrence remains high. Adjuvant radiation (ART) has be...

    Authors: Jiawei Zhu, Ziye Zheng, Jing Shen, Xin Lian, Zheng Miao, Jie Shen and Fuquan Zhang

    Citation: Radiation Oncology 2020 15:118

    Content type: Research

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  31. Patients with left-sided breast cancer have an increased risk of cardiovascular disease (CVD) after radiotherapy (RT). While the awareness of cardiac toxicity has increased enormously over the last decade, the...

    Authors: Aurélie Gaasch, Stephan Schönecker, Cristoforo Simonetto, Markus Eidemüller, Montserrat Pazos, Daniel Reitz, Maya Rottler, Philipp Freislederer, Michael Braun, Rachel Würstlein, Nadia Harbeck, Maximilian Niyazi, Claus Belka and Stefanie Corradini

    Citation: Radiation Oncology 2020 15:117

    Content type: Research

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  32. Sarcopenia is defined by a loss of skeletal muscle mass with or without loss of fat mass. Sarcopenia has been associated to reduced tolerance to treatment and worse prognosis in cancer patients, including pati...

    Authors: Romain Mallet, Romain Modzelewski, Justine Lequesne, Sorina Mihailescu, Pierre Decazes, Hugues Auvray, Ahmed Benyoucef, Fréderic Di Fiore, Pierre Vera, Bernard Dubray and Sébastien Thureau

    Citation: Radiation Oncology 2020 15:116

    Content type: Research

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  33. Stereotactic radiosurgery (SRS) is an effective treatment for trigeminal neuralgia (TN). Nevertheless, a proportion of patients will experience recurrence and treatment-related sensory disturbances. In order t...

    Authors: Alfredo Conti, Gueliz Acker, Antonio Pontoriero, Juliane Hardt, Anne Kluge, Alberto Cacciola, Giuseppe Iatì, Markus Kufeld, Volker Budach, Peter Vajkoczy, Giancarlo Beltramo, Stefano Pergolizzi, Achille Bergantin, Franziska Loebel, Silvana Parisi, Carolin Senger…

    Citation: Radiation Oncology 2020 15:115

    Content type: Research

    Published on:

  34. We evaluated whether pre- and mid-treatment metabolic tumor volume (MTV) predicts per lesion local recurrence (LR) in patients treated with definitive radiation therapy (RT, dose≥60 Gy) for locally advanced no...

    Authors: Michael S. Binkley, Julie L. Koenig, Mehr Kashyap, Michael Xiang, Yufei Liu, Quaovi Sodji, Peter G. Maxim, Maximilian Diehn, Billy W. Loo Jr and Michael F. Gensheimer

    Citation: Radiation Oncology 2020 15:114

    Content type: Research

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  35. The number of nonagenarian cancer patients (≥ 90 years) is continuously increasing, and radiotherapy is performed in a relevant proportion of patients, as surgery and chemotherapy are often not feasible for th...

    Authors: Tanja Sprave, Alexander Rühle, Raluca Stoian, Alina Weber, Constantinos Zamboglou, Carsten Nieder, Anca-Ligia Grosu and Nils H. Nicolay

    Citation: Radiation Oncology 2020 15:113

    Content type: Research

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  37. To report the long-term outcomes of neoadjuvant altered fractionation short-course radiotherapy in 271 consecutive patients with stage II-III rectal cancer.

    Authors: Hans Geinitz, Carsten Nieder, Lukas Kocik, Christine Track, Johann Feichtinger, Theresa Weingartner, Kurt Spiegl, Barbara Füreder-Kitzmüller, Johanna Kaufmann, Dietmar H. Seewald, Reinhold Függer, Andreas Shamiyeh, Andreas L. Petzer, David Kiesl and Josef Hammer

    Citation: Radiation Oncology 2020 15:111

    Content type: Research

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  38. Soft tissue sarcomas (STS) treatment remains a therapeutic challenge. Intraoperative radiotherapy (IORT) resembles a safe and efficient for STS treatment. The first data on electronic-IORT (eIORT) using low-en...

    Authors: Gustavo R. Sarria, Vera Petrova, Frederik Wenz, Yasser Abo-Madyan, Elena Sperk and Frank A. Giordano

    Citation: Radiation Oncology 2020 15:110

    Content type: Research

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  39. Prognostic models based on high-dimensional omics data generated from clinical patient samples, such as tumor tissues or biopsies, are increasingly used for prognosis of radio-therapeutic success. The model de...

    Authors: Daniel Samaga, Roman Hornung, Herbert Braselmann, Julia Hess, Horst Zitzelsberger, Claus Belka, Anne-Laure Boulesteix and Kristian Unger

    Citation: Radiation Oncology 2020 15:109

    Content type: Research

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  41. Neoadjuvant radiotherapy has been shown to improve marginal negative resection and local control of Pancreatic Ductal Adenocarcinoma (PDAC). However, whether it improves overall survival (OS) in patients with ...

    Authors: Dan Wang, Chongshun Liu, Yuan Zhou, Tingyu Yan, Chenglong Li, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Cenap Güngör and Yuqiang Li

    Citation: Radiation Oncology 2020 15:107

    Content type: Research

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  43. Photo-neutrons are produced at the head of the medical linear accelerators (linac) by the interaction of high-energy photons, and patients receive a whole-body-absorbed dose from these neutrons. The current st...

    Authors: Younes Afkham, Asghar Mesbahi, Abdolali Alemi, Farhad Zolfagharpour and Nasrollah Jabbari

    Citation: Radiation Oncology 2020 15:105

    Content type: Research

    Published on:

  44. Structure delineation is a necessary, yet time-consuming manual procedure in radiotherapy. Recently, convolutional neural networks have been proposed to speed-up and automatise this procedure, obtaining promis...

    Authors: Mark H. F. Savenije, Matteo Maspero, Gonda G. Sikkes, Jochem R. N. van der Voort van Zyp, Alexis N. T. J. Kotte, Gijsbert H. Bol and Cornelis A. T. van den Berg

    Citation: Radiation Oncology 2020 15:104

    Content type: Research

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  45. Volumetric modulated arc therapy (VMAT) adopted in post-mastectomy radiation therapy (PMRT) has the capacity to achieve highly conformal dose distributions. The research aims to evaluate the impact of position...

    Authors: Xiongfei Liao, Fan Wu, Junxiang Wu, Qian Peng, Xinghong Yao, Shengwei Kang, Yanqun Zhao and Lucia Clara Orlandini

    Citation: Radiation Oncology 2020 15:103

    Content type: Research

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  46. Radiotherapy treatment of head and neck cancer affects local arteries and increases the risk of stroke. This study aimed at a closer characterization of this damage and its development in time with a longitudi...

    Authors: Cristoforo Simonetto, Michael Mayinger, Thamer Ahmed, Kai Borm, Pavel Kundrát, Steffi Pigorsch, Jan Christian Kaiser and Stephanie E. Combs

    Citation: Radiation Oncology 2020 15:102

    Content type: Research

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  49. Skull base chordomas are rare and heterogeneously behaving tumors. Though still classified as benign they can grow rapidly, are locally aggressive, and have the potential to metastasize. To adapt the treatment...

    Authors: Anna-Lena Hottinger, Beat Bojaxhiu, Frank Ahlhelm, Marc Walser, Barbara Bachtiary, Stefan Zepter, Tony Lomax, Alessia Pica and Damien C. Weber

    Citation: Radiation Oncology 2020 15:96

    Content type: Research

    Published on:

  50. Radiotherapy used in tumor treatment compromises vascularization of bone tissue. Hyperbaric oxygenation (HBO) increases oxygen availability and improves vascularization, minimizing the deleterious effects of i...

    Authors: Luiz Henrique Ferreira Júnior, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Paula Dechichi, Letícia de Souza Castro Filice, Paulo Sérgio Quagliatto and Flaviana Soares Rocha

    Citation: Radiation Oncology 2020 15:95

    Content type: Research

    Published on:

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