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  1. Lobular carcinomas in situ (LCIS) represent 1-2% of all breast cancers. Both significance and treatment remain widely debated, as well as the possible similarities with DCIS.

    Authors: Bruno Cutuli, Brigitte De Lafontan, Youlia Kirova, Hugues Auvray, Agnes Tallet, Sandrine Avigdor, Claire Brunaud and Catherine Delva
    Citation: Radiation Oncology 2015 10:110
  2. Rhabdomyosarcoma (RMS) is the most common sarcoma in paediatric patients. A perianal site is unusual and is associated with a low cure rate. The few cases of reported perianal RMS have been associated with seq...

    Authors: Charlotte Demoor-Goldschmidt, Sophie Dumoucel, Christine Haie-Meder, Nadège Corradini, Marc-André Mahé and Stéphane Supiot
    Citation: Radiation Oncology 2015 10:108
  3. The optimal fractionation schedule of radiotherapy (RT) for Glioblastoma multiforme (GBM) is yet to be determined. We aim to compare different fractionation regimens and identify prognostic factors to better t...

    Authors: Melissa Azoulay, Fabiano Santos, Luis Souhami, Valerie Panet-Raymond, Kevin Petrecca, Scott Owen, Marie-Christine Guiot, Mariia Patyka, Siham Sabri, George Shenouda and Bassam Abdulkarim
    Citation: Radiation Oncology 2015 10:106
  4. The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radio...

    Authors: Simone Fulda
    Citation: Radiation Oncology 2015 10:105
  5. To improve the delivery of radiotherapy in gynecologic malignancies and to minimize the irradiation of unaffected tissues by using daily kilovoltage cone beam computed tomography (kV-CBCT) to reduce setup errors.

    Authors: Lihong Yao, Lihong Zhu, Junjie Wang, Lu Liu, Shun Zhou, ShuKun Jiang, Qianqian Cao, Ang Qu and Suqing Tian
    Citation: Radiation Oncology 2015 10:104
  6. Radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome is a rarely observed phenomenon characterized by infiltration of the lungs outside of the radiation field, differentiating it fro...

    Authors: Keiko Nemoto Murofushi, Masahiko Oguchi, Masahiko Gosho, Takuyo Kozuka and Hideyuki Sakurai
    Citation: Radiation Oncology 2015 10:103
  7. Small cell carcinoma of the rectum is a rare neoplasm with scant literature to guide treatment. We used the Surveillance Epidemiology and End Results (SEER) database to investigate the role of radiation therap...

    Authors: Aram S Modrek, Howard C Hsu, Cynthia G Leichman and Kevin L Du
    Citation: Radiation Oncology 2015 10:101
  8. Textural features in FDG-PET have been shown to provide prognostic information in a variety of tumor entities. Here we evaluate their predictive value for recurrence and prognosis in NSCLC patients receiving p...

    Authors: Thomas Pyka, Ralph A Bundschuh, Nicolaus Andratschke, Benedikt Mayer, Hanno M Specht, Laszló Papp, Norbert Zsótér and Markus Essler
    Citation: Radiation Oncology 2015 10:100
  9. Radiation-induced rib fracture after stereotactic body radiotherapy (SBRT) for lung cancer has been recently reported. However, incidence of radiation-induced rib fracture after SBRT using moderate fraction si...

    Authors: Masahiko Aoki, Mariko Sato, Katsumi Hirose, Hiroyoshi Akimoto, Hideo Kawaguchi, Yoshiomi Hatayama, Shuichi Ono and Yoshihiro Takai
    Citation: Radiation Oncology 2015 10:99
  10. To determine the long-term impact of stereotactic radiotherapy (SRT) on the quality of life (QoL) of inoperable patients with early-stage non-small cell lung cancer (NSCLC).

    Authors: Rutger J Ubels, Sahar Mokhles, Eleni R Andrinopoulou, Cornelia Braat, Noëlle C van der Voort van Zyp, Shafak Aluwini, Joachim G J V Aerts and Joost J Nuyttens
    Citation: Radiation Oncology 2015 10:98
  11. Machine Performance Check (MPC) is an application to verify geometry and beam performances of TrueBeam Linacs, through automated checks based on their kV-MV imaging systems. In this study, preliminary tests wi...

    Authors: Alessandro Clivio, Eugenio Vanetti, Steven Rose, Giorgia Nicolini, Maria F Belosi, Luca Cozzi, Christof Baltes and Antonella Fogliata
    Citation: Radiation Oncology 2015 10:97
  12. To evaluate the dose-effect relations for myocardial metabolic disorders after mediastinal radiotherapy (RT) by performing iodine-123 β-methyl-iodophenyl pentadecanoic acid (I-123 BMIPP) scintigraphy.

    Authors: Rei Umezawa, Kentaro Takanami, Noriyuki Kadoya, Yujiro Nakajima, Masahide Saito, Hideki Ota, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Ken Takeda, Yasuyuki Taki, Kei Takase and Keiichi Jingu
    Citation: Radiation Oncology 2015 10:96
  13. This is the final report of a prospective phase I study which evaluated the feasibility, toxicities, and biochemical control in prostate cancer patients treated with a hypofractionated boost utilizing a fiduci...

    Authors: William Chu, D Andrew Loblaw, Kelvin Chan, Gerard Morton, Richard Choo, Ewa Szumacher, Cyril Danjoux, Jean-Philippe Pignol and Patrick Cheung
    Citation: Radiation Oncology 2015 10:95
  14. We aimed to study the radiation induced brachial plexopathy in patients with head and neck squamous cell carcinoma (HNSCC) treated with Sequential Intensity Modulated Radiation Therapy (S-IMRT).

    Authors: Tarita O Thomas, Tamer Refaat, Mehee Choi, Ian Bacchus, Sean Sachdev, Alfred W Rademaker, Vythialingam Sathiaseelan, Achilles Karagianis and Bharat B Mittal
    Citation: Radiation Oncology 2015 10:94
  15. A significant number of patients treated for head and neck squamous cell cancer (HNSCC) undergo enteral tube feeding. Data suggest that avoiding enteral feeding can prevent long-term tube dependence and disuse...

    Authors: Sean Sachdev, Tamer Refaat, Ian D Bacchus, Vythialinga Sathiaseelan and Bharat B Mittal
    Citation: Radiation Oncology 2015 10:93
  16. Intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) have been adopted for radiotherapy treatment of anal canal carcinoma (ACC) due to better conformality, dose homogeneity and normal-tissue sp...

    Authors: Rosanna Yeung, Yarrow McConnell, Heather Warkentin, Darren Graham, Brad Warkentin, Kurian Joseph and Corinne M Doll
    Citation: Radiation Oncology 2015 10:92
  17. To compare highly sophisticated intensity-modulated radiotherapy (IMRT) delivered by either helical tomotherapy (HT), RapidArc (RA), IMRT with protons (IMPT) in patients with locally advanced cervical cancer.

    Authors: Simone Marnitz, Waldemar Wlodarczyk, Oliver Neumann, Christhardt Koehler, Mirko Weihrauch, Volker Budach and Luca Cozzi
    Citation: Radiation Oncology 2015 10:91
  18. It is currently not possible to get an approval of our ethics committee for a randomized trial cmparing 5x4 Gy and 10x3 Gy for MSCC that includes patients with favorable survival prognoses. Therefore, this mat...

    Authors: Dirk Rades, Stefan Huttenlocher, Theo Veninga, Amira Bajrovic, Michael Bremer, Volker Rudat and Steven E Schild
    Citation: Radiation Oncology 2015 10:90
  19. To retrospectively analyze the prognostic value of magnetic resonance imaging (MRI)-derived residual tumors after intensity-modulated radiation therapy (IMRT) in the patients with locally-advanced nasopharynge...

    Authors: Yuxiang He, Qin Zhou, Lin Shen, Yajie Zhao, Mingjun Lei, Rui Wei, Liangfang Shen and Shousong Cao
    Citation: Radiation Oncology 2015 10:89
  20. Olfactory neuroblastoma (ONB) is a rare tumor originating from olfactory epithelium. Here we retrospectively analyzed the long-term treatment outcomes and toxicity of radiotherapy for ONB patients for whom com...

    Authors: Takashi Mori, Rikiya Onimaru, Shunsuke Onodera, Kazuhiko Tsuchiya, Koichi Yasuda, Hiromitsu Hatakeyama, Hiroyuki Kobayashi, Shunsuke Terasaka, Akihiro Homma and Hiroki Shirato
    Citation: Radiation Oncology 2015 10:88
  21. To demonstrate that novice dosimetry planners efficiently create clinically acceptable IMRT plans for head and neck cancer (HNC) patients using a commercially available multicriteria optimization (MCO) system.

    Authors: Roel GJ Kierkels, Ruurd Visser, Hendrik P Bijl, Johannes A Langendijk, Aart A van ‘t Veld, Roel JHM Steenbakkers and Erik W Korevaar
    Citation: Radiation Oncology 2015 10:87
  22. Total marrow (lymph-nodes) irradiation (TMI-TMLI) by volumetric modulated arc therapy (VMAT) was shown to be feasible by dosimetric feasibility studies. It was demonstrated that several partially overlapping a...

    Authors: Pietro Mancosu, Pierina Navarria, Giacomo Reggiori, Luca Cozzi, Antonella Fogliata, Anna Gaudino, Francesca Lobefalo, Lucia Paganini, Valentina Palumbo, Barbara Sarina, Antonella Stravato, Luca Castagna, Stefano Tomatis and Marta Scorsetti
    Citation: Radiation Oncology 2015 10:86
  23. The purpose of this study was to investigate the potential dose reduction to the heart, left anterior descending (LAD) coronary artery and the ipsilateral lung for patients treated with tangential and locoregi...

    Authors: Anneli Edvardsson, Martin P Nilsson, Sousana Amptoulach and Sofie Ceberg
    Citation: Radiation Oncology 2015 10:84
  24. Cone-beam computed tomography (CBCT) image-guided radiotherapy (IGRT) systems are widely used tools to verify and correct the target position before each fraction, allowing to maximize treatment accuracy and p...

    Authors: Christine Boydev, Abdelmalik Taleb-Ahmed, Foued Derraz, Laurent Peyrodie, Jean-Philippe Thiran and David Pasquier
    Citation: Radiation Oncology 2015 10:83
  25. The accuracy of the Elekta Clarityâ„¢ three-dimensional ultrasound system (3DUS) was assessed for prostate positioning and compared to seed- and bone-based positioning in kilo-voltage cone-beam computed tomograp...

    Authors: Minglun Li, Hendrik Ballhausen, Nina-Sophie Hegemann, Ute Ganswindt, Farkhad Manapov, Stefan Tritschler, Alexander Roosen, Christian Gratzke, Michael Reiner and Claus Belka
    Citation: Radiation Oncology 2015 10:82
  26. High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this r...

    Authors: Teruhisa Unetsubo, Hidenobu Matsuzaki, Mitsuhiro Takemoto, Kuniaki Katsui, Marina Hara, Norihisa Katayama, Takahiro Waki, Susumu Kanazawa and Jun-ichi Asaumi
    Citation: Radiation Oncology 2015 10:81
  27. Gastrointestinal (GI) toxicity is a common effect following radiation therapy (RT) for prostate cancer. Purpose of the present work is to compare two Normal Tissue Complication Probability (NTCP) modelling app...

    Authors: Vittoria D’Avino, Giuseppe Palma, Raffaele Liuzzi, Manuel Conson, Francesca Doria, Marco Salvatore, Roberto Pacelli and Laura Cella
    Citation: Radiation Oncology 2015 10:80
  28. The aim of the present study was to introduce a new restricted tangential volumetric modulated arc therapy (tVMAT) technique for whole breast irradiation and compare its dosimetric properties to other currentl...

    Authors: Tuomas Virén, Janne Heikkilä, Kimmo Myllyoja, Kristiina Koskela, Tapani Lahtinen and Jan Seppälä
    Citation: Radiation Oncology 2015 10:79
  29. We present a case of radiotherapy for a 66-year-old patient with squamous cell carcinoma on the left main bronchus undergoing implantation of pacemaker, implantable cardioverter defibrillator (ICD) as well as ...

    Authors: Sergiu Scobioala, Iris Ernst, Christos Moustakis, Uwe Haverkamp, Sven Martens and Hans Theodor Eich
    Citation: Radiation Oncology 2015 10:78
  30. Adjuvant radiotherapy (RT) of left-sided breast cancer is increasingly performed in voluntary deep inspiration breath-hold (vDIBH). The aim of this study was to estimate the reproducibility of breath-hold leve...

    Authors: Marko Laaksomaa, Mika Kapanen, Mikko Haltamo, Tanja Skyttä, Seppo Peltola, Simo Hyödynmaa and Pirkko-Liisa Kellokumpu-Lehtinen
    Citation: Radiation Oncology 2015 10:76
  31. Intensity modulated radiotherapy treatment planning for sites with many different organs-at-risk (OAR) is complex and labor-intensive, making it hard to obtain consistent plan quality. With the aim of addressi...

    Authors: Jim P Tol, Max Dahele, Jarkko Peltola, Janne Nord, Ben J Slotman and Wilko FAR Verbakel
    Citation: Radiation Oncology 2015 10:75
  32. Re-contouring of structures on consecutive planning computed tomography (CT) images for patients that exhibit anatomical changes is elaborate and may negatively impact the turn-around time if this is required ...

    Authors: Ihab S Ramadaan, Karsten Peick, David A Hamilton, Jamie Evans, Douglas Iupati, Anna Nicholson, Lynne Greig and Robert J W Louwe
    Citation: Radiation Oncology 2015 10:73
  33. Newly diagnosed WHO grade II-III or any WHO grade recurrent meningioma exhibit an aggressive behavior and thus are considered as high- or intermediate risk tumors. Given the unsatisfactory rates of disease con...

    Authors: Indira Madani, Antony J Lomax, Francesca Albertini, Petra Trnková and Damien C Weber
    Citation: Radiation Oncology 2015 10:72
  34. Palliative irradiation of osteolytic lesions is a considerable component in the treatment for patients with multiple myeloma. In this study, we analyzed the efficacy of irradiation in these patients.

    Authors: Christiane Matuschek, Thomas A Ochtrop, Edwin Bölke, Ute Ganswindt, Roland Fenk, Stephan Gripp, Patric Kröpil, Peter Arne Gerber, Kai Kammers, Jackson Hamilton, Klaus Orth and Wilfried Budach
    Citation: Radiation Oncology 2015 10:71
  35. To investigate the incidence and risk of severe late toxicity with concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma patients.

    Authors: Cheng-run Du, Hong-mei Ying, Fang-fang Kong, Rui-ping Zhai and Chao-su Hu
    Citation: Radiation Oncology 2015 10:70
  36. Knowing the technical characteristics of gated radiotherapy equipment is crucial for ensuring precise and accurate treatment when using techniques such as Deep-Inspiration Breath-Hold and gating under free bre...

    Authors: Philipp Freislederer, Michael Reiner, Winfried Hoischen, Anton Quanz, Christian Heinz, Franziska Walter, Claus Belka and Matthias Soehn
    Citation: Radiation Oncology 2015 10:68
  37. To estimate dose–response relationship using dynamic quantitative 99mTc-pertechnate scintigraphy in head-neck cancer patients treated with parotid-sparing conformal radiotherapy.

    Authors: Tejpal Gupta, Chandni Hotwani, Sadhana Kannan, Zubin Master, Venkatesh Rangarajan, Vedang Murthy, Ashwini Budrukkar, Sarbani Ghosh-Laskar and Jai Prakash Agarwal
    Citation: Radiation Oncology 2015 10:67
  38. To explore the interobserver variability in the delineation of the tumour bed using seroma and surgical clips based on the four-dimensional computed tomography (4DCT) scan for external-beam partial breast irra...

    Authors: Bing Guo, Jianbin Li, Wei Wang, Min Xu, Qian Shao, Yingjie Zhang, Chaoqian Liang and Yanluan Guo
    Citation: Radiation Oncology 2015 10:66
  39. Previous reports establish low risk of complications in pediatric treatments under anesthesia/sedation (A/S) in the outpatient setting. Here, we present our institutional experience with A/S by age and gender...

    Authors: Kevin P McMullen, Tara Hanson, Jennifer Bratton and Peter A S Johnstone
    Citation: Radiation Oncology 2015 10:65
  40. The main objective of this study was to evaluate the efficacy of integrating the blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI) and diffusion tensor imaging (DTI) data into radi...

    Authors: Minglei Wang, Hui Ma, Xiaodong Wang, Yanhong Guo, Xinshe Xia, Hechun Xia, Yulin Guo, Xueying Huang, Hong He, Xiaoxiong Jia and Yan Xie
    Citation: Radiation Oncology 2015 10:64
  41. To evaluate the local control of brain metastases (BM) in patients treated with stereotactic radiosurgery (SRS), correlate the outcome with treatment parameters and lesion characteristics, and define its impli...

    Authors: Tâmara Ribeiro de Azevedo Santos, Carmen Freire Tundisi, Henderson Ramos, Maria Aparecida Conte Maia, Antônio Cássio Assis Pellizzon, Maria Letícia Gobo Silva, Ricardo César Fogaroli, Michael Jenwei Chen, Sérgio Hideki Suzuki, José Eduardo Souza Dias Jr, Paulo Issamu Sanematsu Jr and Douglas Guedes de Castro
    Citation: Radiation Oncology 2015 10:63
  42. We designed this study to quantify the effects of radiotherapy (RT) on bone density as a local response in spinal bone metastases of women with breast cancer and, secondly, to establish bone density as an accu...

    Authors: Robert Foerster, Christian Eisele, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Robert Wolf, Juergen Debus and Harald Rief
    Citation: Radiation Oncology 2015 10:62
  43. To analyze survival after early palliative radiotherapy (RT) in patients managed exclusively by regular oncology staff or a multidisciplinary palliative care team (MPCT) in addition.

    Authors: Carsten Nieder, Astrid Dalhaug, Adam Pawinski, Ellinor Haukland, Bård Mannsåker and Kirsten Engljähringer
    Citation: Radiation Oncology 2015 10:61
  44. Clinical data that compare external-beam radiotherapy (EBRT) combined with high-dose-rate brachytherapy (HDR-BT) boost versus EBRT alone are scarce. The analysis of published studies suggest that biochemical r...

    Authors: Beata Smolska-Ciszewska, Leszek Miszczyk, Brygida Białas, Marek Fijałkowski, Grzegorz Plewicki, Marzena Gawkowska-Suwińska, Monika Giglok, Katarzyna Behrendt, Elżbieta Nowicka, Aleksander Zajusz and Rafał Suwiński
    Citation: Radiation Oncology 2015 10:60

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