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Intensity-modulated radiotherapy with simultaneous integrated boost for locoregionally advanced nasopharyngeal carcinoma



To compare the treatment outcomes of intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) alone to concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (NPC).


From November 2001 to December 2009, 333 patients with pathologically diagnosed, locoregionally advanced NPC were treated by IMRT-SIB with or without weekly cisplatin concurrent chemotherapy at our institute. Among them, 62 patients received neo- or adjuvant chemotherapy or molecular target drugs were excluded from this analysis. There were 129 patients received IMRT-SIB alone, and 142 patients received IMRT-SIB with weekly cisplatin 30 mg/m2 for 7 weeks. The radiotherapy protocol was identical for each group.


There were no significant differences in survival between CCRT and IMRT-SIB group in terms of gender, T/N classifications and concurrent chemoradiotherapy. The 5-year local control (LC), overall survival (OS), disease-free survival (DFS) and distant metastasis-free survival (DMFS) for the entire group were 87.0%, 79.4%, 69.7 and 83.3%, respectively. The LC, OS, DFS and DMFS for CCRT and IMRT-SIB alone groups were 80.6% vs. 90.8% (P = 0.10), 71.7% vs. 83.2% (P = 0.201), 63.9% vs. 74.6% (P = 0.07), and 79.6% vs. 86.0% (P = 0.27), respectively.


Compared to CCRT, IMRT-SIB alone had demonstrated similar disease LC, OS, DFS and DMFS in locoregionally advanced NPC. Careful radiation target volume design and simultaneous integrated boost may play a role that overrides the benefit from concurrent chemotherapy. Further investigation with randomized study is necessary to determine whether IMRT-SIB alone can achieve similar outcomes of concurrent chemoradiotherapy.


Majority patients with nasopharyngeal carcinomas (NPC) present with locoregionally advanced stages at diagnosis, the treatment modality with concurrent chemoradiotherapy has demonstrated superior to radiotherapy (RT) alone in terms of disease locoregional control and survivals, cisplatin based chemoradiotherapy has improved 5-year overall survival from 50% to 75% [16]. In the past 15-years, IMRT technique has widely utilized in the treatment of head and neck cancers, particularly in NPC due to anatomic complexity and benefits in accurately encompassing tumor targets and reducing organ at risk’s (OAR) toxicities. Two-dimensional (2D) or 3-dimensional techniques (3D) has been used in the previous published NPC studies, it is unknown whether IMRT alone with accurate tumor delineations and the technique of IMRT-SIB could achieve similar outcomes of disease loco-regional control. The theory supporting this hypothesis is the majority of NPC in Asia are poor or undifferentiated histology, and NPC is a type of sensitive tumor to RT or CCRT, comparing 2D conventional RT, sophisticated IMRT-SIB provides the advantage of adequate target coverage with concaved shape of nasopharyngeal carcinoma target volume, and limit toxicity to adjacent critical structures [7, 8]. Several studies have shown that compared to 2D technique, IMRT improved NPC disease local controls and reduced radiation associated toxicities [911]. It is reasonable to postulate that the local control improvement of nasopharyngeal carcinoma treated by IMRT-SIB will be translated into overall survival benefit. To investigate whether IMRT-SIB alone can achieve outcomes that are as effective as the published data on locoregional control and survival in NPC patients, we conducted a retrospective cohort study for patients with locoregionally advanced NPC that were all treated with IMRT-SIB technique alone or concurrent with weekly cisplatin. The results may provide some clinical evidences that IMRT-SIB may be applied for selected locoregionally advanced NPC.


Patient’s inclusion criteria

From November 2001 through December 2009, totally 416 pathologically proven nasopharyngeal carcinoma patients were treated with IMRT-SIB technique in our hospital. There were 333 patients in stage III, IVA/B when reevaluated according to the 6th UICC staging system, sixty-two patients were excluded from this study for receiving induction and/or adjuvant chemotherapy (n = 20), or epidermal growth factor receptor inhibitors (n = 42). There were 197 males and 74 females; the median age was 47 (range, 12-81). Initial evaluation included complete physical examination, fiberoptic nasopharyngoscopy, chest image (X-ray film and CT scan for N3 patients), MRI or CT of the nasopharynx including skull base and neck region, blood routine tests, and complete metabolic chemistries. Part of patients came from a clinical trial in which the role of concurrent chemoradiotherapy were compared regardless of the treatment technique, by this reason, there were 129 patients received IMRT-SIB alone, and 142 patients received IMRT-SIB with current chemotherapy.


All patients were treated with 6MV-X by Varian 600C/D linear accelerator, 5 fractions per week, with a total treatment time of 6.5 weeks. The radiotherapy protocol for IMRT-SIB alone and CCRT group was identical. The whole neck IMRT technique was used to cover the primary lesion, nodal disease and entire neck including supraclavicular region. The prescription dose to T1 and T2 primary lesion (GTVp) was 70 Gy in 33 fractions at 2.12 Gy per fraction, while 74 Gy at 2.24 Gy per fraction to T3 or T4 disease and involved retropharyngeal nodes with largest diameter >1.5 cm, all positive lymph node (GTVnd) were given 70 Gy at 2.12 Gy per fraction. The elective radiation dose of 60 Gy at 1.82 Gy per fraction encompasses the high risk regions including uninvolved skull base, parapharyngeal space, posterior one-third of nasal cavity and high risk nodal levels. If there were no positive neck node in the neck, 50-54 Gy was delivered to the bilateral lower neck and supraclavicular region using a two-phase IMRT plan, with phase 1 IMRT plan (28 treatment fractions) cover primary lesion, positive nodes, high risk region and the lower neck/supraclavicular region, the phase 2 IMRT plan (5 treatment fractions) cover only the primary lesion, positive nodes and high risk regions. The dose constraints for major organs at risk were shown as follow: brain stem with 3 mm margin, Dmax < 54 Gy; spinal cord with 5 mm margin, Dmax < 40 Gy; optic nerve, chiasm and temporal lobe, Dmax < 54 Gy; parotid gland, V30-35 < 50%.


Planned chemotherapy was consisted of weekly intravenous cisplatin at 30 mg/m2 for 7 weeks.

Management of residual primary lesions

At the end of treatment, there were 53 patients have residual disease at the primary sites that were documented by MRI and/or endoscopic examination: 22 (15.5%) in CCRT group and 31 (24.0%) in IMRT-SIB alone group. Salvage local treatments include IMRT boost with a mean dose of 8 Gy (range, 4-15 Gy) at 2-3 Gy per fraction (n = 25) or Linac-based stereotactic radiotherapy treatment (SRT) 20 Gy (range, 10-24 Gy) at 2-4 Gy per fraction (n = 28).

Intra- and Post-treatment assessments

Tumor response was assessed at 50 Gy by clinical exam including endoscopy and/or imaging study. If the volume and geometry of primary lesion and positive nodes were changed significantly, the second CT-simulation was performed and PTV volumes were modified corresponding to significant GTVs regression. A new IMRT plan was designed and started at the 29th treatment fraction in order to avoid treatment break. Patients received physical examination once a week during the treatment, the radiotherapy related toxicities were graded according to the Acute and Late Scoring Criteria of the Radiation Therapy Oncology Group and chemotherapy-related toxicities was evaluated by the CTC 2.0 or CTCAE3.0. If there were grade 4 hematology toxicities and radiotherapy-related mucositis occurred, the treatment would suspend until the toxicities were recovered. The first post-treatment follow-up was at 1 month, then every 3 months for the first 2 years, every 6 months thereafter for 3-5 years, and then once a year.

Statistical methods

The statistic was performed by SPSS 13.0 software, Kaplan-Meier method was used for calculating the survival, and Log-rank test was used for evaluating the differences between the two groups.


Patient characteristics

From November 2001 to December 2009, there were totally 271 newly diagnosed locally advanced nasopharyngeal carcinoma treated with IMRT-SIB with or without concurrent cisplatin-based chemotherapy in our institution. The characteristics of patients and treatment modality were shown in Table 1. There were well balanced between the groups of IMRT-SIB alone and CCRT in terms of gender, age, T classification, clinical stage, and median RT dose to the GTVs.

Table 1 The characteristics of patients between IMRT-SIB and CCRT

Patient compliance

All patients completed RT as planned. Of 142 patients in CCRT group, 127 (89.4%) received 5 and more cycles of weekly chemotherapy, while 15 patients (10.6%) had 4 cycles or less.

Acute toxicities

Acute toxicities presenting in the groups of CCRT and IMRT-SIB alone were: grade 3 mucositis, 24.1% versus 29.3% (P = 0.531); grade 2 and 3 neutropenia, 32.7% versus 8%, and 2% versus 0%, respectively (P = 0.008); grade 1 anemia 42.8% versus 24.5%, grade 2 anemia, 6% versus 0% (p = 0.066). Grade 3 radiation dermatitis was 11.1% in both CCRT and IMRT-SIB alone group. Only 1 patient in CCRT group had grade 1 abnormal liver function tests. There were no grade3 or higher anemia observed in either group.

Treatment outcomes

The 5-year LC, OS, DFS and DMFS for the entire group were 87.0%, 79.4%, 69.7 and 83.3%, respectively. The 5-year LC, OS, DFS and DMFS of CCRT versus IMRT-SIB-alone groups were 80.6% and 90.8% (P = 0.10), 71.7% and 83.2% (P = 0.201), 63.9% and 74.6% (P = 0.07), 79.6% and 86.0% (P = 0.27), respectively. For stage IVA patients, the 5-year DFS, DMFS were 34.3% and 74.7% (p = 0.01), 68.1% and 95.5% (p = 0.03) in CCRT (n = 39) and IMRT-SIB alone group (n = 24), respectively. For N0-1 patients, the 5-year DMFS were 67.3% and 96.9% (p = 0.02) in CCRT (n = 32) and IMRT-SIB alone group (n = 35).

Univariate analysis including age, gender, T stage and clinical stage showed that there were no significant differences of overall survival between CCRT and IMRT-SIB alone groups (Table 2). No independent prognosis factor was found by multivariate analysis. Figures 1 and 2 showed the local control of T3 and T4 patients.

Table 2 The differences of treatment outcomes between CCRT and IMRT-SIB RT alone
Figure 1
figure 1

The local control rate of T3 patients treated by IMRT-SIB alone and CCRT.

Figure 2
figure 2

The local control rate of T4 patients treated by IMRT-SIB alone and CCRT.


Several randomized clinical trials have demonstrated that concurrent chemoradiotherapy is superior to radiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Al-sarraf et al. [1] first reported that, compared to RT alone, concurrent cisplatin chemoradiotherapy and adjuvant chemotherapy with cisplatin and 5-Fluorouracil improved 5 years overall survival from 37% to 67% (p = 0.001). Wee et al. [6] confirmed the advantage of CCRT with adjuvant chemotherapy in NPC epidemic regions. At the same period, there were more and more data from nasopharyngeal carcinoma epidemic areas showed that CCRT with or without adjuvant chemotherapy improved the overall survival when compared with RT alone [3, 5, 12]. These clinical trials confirmed that advantage of CCRT with or without adjuvant chemotherapy have improved local-regional controls [1, 5, 6], some studies revealed decreases of distant metastases [3, 4, 12] or both locoregional control and distant metastases [1, 5, 6]. The meta-analysis also showed that the CCRT was superior to RT alone in nasopharyngeal carcinoma epidemic areas [13]. In Chen’s study [14], 508 patients were randomly assigned to the CCRT followed by adjuvant chemotherapy (n = 251) and CCRT alone group (n = 257), the 2-year overall survival was similar, 94% and 92 (p = 0.32). Based on these evidences, CCRT with or without adjuvant chemotherapy has become the standard care for locoregionally advanced nasopharyngeal carcinoma. However, most of these evidences of standard treatment for locoregionally advanced nasopharyngeal carcinoma were based on the 2D or non-IMRT technique. As the IMRT technique has been widely used in the last decades, and outcome of significant disease locoregional control, people started to reconsider the role of CCRT. In Hong Kong NPC clinical trials (NPC 9901/9902), there were 50% patients received either 3D conformal or IMRT, the results showed that there were no significant differences in terms of overall survival between the groups of CCRT and RT alone [15, 16], although the combined analysis of Hong Kong NPC 9901/9902 studies revealed that patients who received CCRT did well in overall survival [17].

Due to the complex anatomic location of nasopharynx, it is technically challenging to deliver the definitive dose to field without partially missing GTV coverage using 2-D RT technique. Such problem can be avoided with the use of IMRT. Furthermore, with IMRT-SIB technique, there are two aspects of radiobiology rationale to improve treatment results: shorten the overall treatment time and increase the fractionation dose to gross tumor volumes [18]. Several studies have confirmed the safety and efficacy of IMRT-SIB in the treatment of NPC. Lee et al. [9], Kwong et al. [19] and Xiao et al. [20] all reported very promising results of locally advanced nasopharyngeal carcinoma treated with IMRT-SIB. In Xiao’s study [20], the prescription dose to NPC GTVs was 68 Gy given in 30 fractions, 2.27 Gy per fraction. The 5-year disease local control, disease-free and overall survivals were 94.9%, 76.7% and 74.5%, respectively. All toxicities were expected, and no exceed treatment complications due to use of IMRT-SIB. In the past 10 years, IMRT-SIB has been more often used in locoregionally advanced head and neck cancer including NPC treatments. Large sample studies from NPC epidemic areas have demonstrated outcome improvements, see Table 3.

Table 3 The outcome of NPC treated by 2D technique and IMRT-SIB in epidemic areas

Our results did not demonstrate any significant differences in disease local control, overall survival, disease-free survival and distant-metastasis free survival between patients treated with IMRT-SIB alone or with concurrent chemotherapy. Besides the better dose coverage provided by IMRT technique compared to the 2D technique, there were several other reasons may interpret our results. One is the prescription doses to the gross target volume were 74 Gy with 2.24 Gy/fraction for T3/T4 lesions, the equivalent biological dose were 75.5 Gy if given by 2 Gy/fraction according to the L-Q model, which is about 7.8% increased of total dose when compared to 70 Gy/2 Gy per fraction in the 2D era. If we refer to dose-response curve for head and neck cancer [27], with a γ37 of 2, the local control rate of our patients would be 15.6% higher than those patients who received 70 Gy with 2 Gy/fraction in the 2D era, Actually, the local control rate of RT alone groups in those randomized clinical trials compared the concurrent chemoradiotherapy with radiotherapy alone in 2D era were about 67%-72% [1, 5, 6], while the 5-year local control of our study was 87%, which was about 15% higher, which may extrapolate a potential increase of overall survival. The reason for choosing a higher prescription dose for T3/4 lesions was based on that there were larger tumor burden in T3/4 lesions than those in T1/2 lesions, and a larger tumor burden needs a higher dose to control. Sze et al. [28] found that the overall correlation between T stage and tumor volume was strongly significant in 308 nasopharyngeal carcinoma patients, the risk of local failure was estimated to increase by 1% for every 1 cm3 increase in primary tumor volume. Secondly, with IMRT-SIB, the overall treatment time were 45 days for T3/4 patients, there were 6 days reduced when compared with those who treated by 2D conventional radiotherapy. Shorten overall treatment time will benefit to overcome the tumor cell repopulation and potentially improve disease local control. Also, in our series, there were 53 patients with residual lesions at the end of treatment, received additional boost either by IMRT or SRT. All these factors would improve our treatment outcomes compared to those come from 2D era in the literature. Our previously published data also showed the patients with residual lesions received boost dose irradiation had the same local control as those who had no residual disease at the end of RT [24]. Teo et al. [29] reported dose-escalation above 66 Gy significantly improved local control for T1/T2a and T3/4 tumors when compared to 2D Ho's technique.

Su et al. [26] also found that, comparing to IMRT alone, adding chemotherapy to IMRT did not improve the outcomes for locally advanced NPC. In their study, of 603 patients with T3-4 N2-3 NPC treated with IMRT, 101 were treated with IMRT alone, 222 patients with cisplatin-based CCRT (CCRT group), 207 patients with induction chemotherapy followed by CCRT (IC + CCRT group), 38 patients received IMRT with either induction chemotherapy or adjuvant chemotherapy (IC or Adj group) and 35 had CCRT followed by adjuvant chemotherapy (Con + Adj group). The 5 years overall survival was 77.2% for IMRT group alone, 78.7% for CCRT group, 73.4% for IC + CCRT group, 82.3% for IC or Adj group and 80.6% for Con + Adj group (P = 0.59). There were no significant survival differences no matter them received chemotherapy or not. Of those with locoregionally advanced NPCs who will benefit from CCRT or RT alone? Lin et al. [30] divided the stage III/IVM0 (1992 AJCC staging system) patients from their previously randomized trial [5] into high risk group and lower risk group. The high risk group included patients who met at least one of following criteria: nodal size >6 cm, supraclavicular node metastases, 1992 AJCC stage T4N2, multiple neck node metastases with at least 1 node >4 cm; the others without any high risk factors were in low risk group. The results showed that only low risk group patients benefited from CCRT compared to the RT alone. The 5-year disease LC and OS were 95.1% and 85.3% in CCRT group, the disease local control improvement has been translated into an OS benefit. But, when compared to the Lin’s data, in our study, LC and OS for stage III patients (similar to Lin’s lower risk group) treated with IMRT-SIB alone were 95.6% and 88.3%, is similar to those in Lin’s lower risk group who treated with CCRT. That is to say, in some selected patients (for example, UICC stage III patients), IMRT-SIB alone may be an alternative treatment choice.

Several pitfalls need to be addressed. Selection bias in a retrospective study could have impacted on our results. However, we included all consecutive patients with stage III and non-metastatic stage IV NPC treated with IMRT-SIB in our institution except for those received neo- or adjuvant chemotherapy or molecular target drugs. Second, the cumulative cisplatin dose from our weekly chemotherapy regimen was 180-210 mg/m2, which was lower than the recommended standard total dose of 300 mg/m2, as there was a positive relationship between the total cisplatin dose and treatment outcomes locally advanced squamous cell carcinoma of head and neck [31]. As CCRT with high acute treatment-related toxicities in patients who received cisplatin regimen of 100 mg/m2, about 30% patients could not receive the third cycle of cisplatin [32]. Kim et al. [33] compared and analyzed the tumor response, the overall survival, the toxicity and the chemotherapy dose intensity in the patients with locally advanced nasopharyngeal cancer who were treated with a 3-week cycle of 100 mg/m2 cisplatin or 30 mg/m2 weekly cisplatin, the author conclude that weekly 30 mg/m2 cisplatin-based CCRT is a practical, feasible cisplatin schedule for the patients with locally advanced nasopharyngeal cancer in regard to decreasing the interruption of radiation treatment and the treatment-related acute toxicities. So the total dose in our study might be reasonable. We are not clear about the worse outcomes in terms of DFS and DMFS in CCRT group compared to IMRT-SIB alone group for stage IVA and N0-1 patients, the possible reasons maybe the sample size and the bias of a retrospective study.


IMRT-SIB alone achieved similar treatment outcomes as compared to concurrent chemotherapy and IMRT-SIB in terms of disease local control and overall survival. However, such results need further investigation in a prospective randomized clinical trial.

Ethical statement

  1. 1.

    This study has been approved by ethics committee of cancer hospital, Chinese academy of Medical Sciences.

  2. 2.

    All patients have given their written consent to be included in research studies prior to their treatment.


  1. Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, Forastiere AA, Adams G, Sakr WA, Schuller DE, Ensley JF: Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998, 16: 1310-1317.

    CAS  PubMed  Google Scholar 

  2. Baujat B, Audry H, Bourhis J, Chan AT, Onat H, Chua DT, Kwong DL, Al-Sarraf M, Chi KH, Hareyama M, Leung SF, Thephamongkhol K, Pignon JP: Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys 2006, 64: 47-56. 10.1016/j.ijrobp.2005.06.037

    Article  CAS  PubMed  Google Scholar 

  3. Chan AT, Teo PM, Ngan RK, Leung TW, Lau WH, Zee B, Leung SF, Cheung FY, Yeo W, Yiu HH, Yu KH, Chiu KW, Chan DT, Mok T, Yuen KT, Mo F, Lai M, Kwan WH, Choi P, Johnson PJ: Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial. J Clin Oncol 2002, 20: 2038-2044. 10.1200/JCO.2002.08.149

    Article  CAS  PubMed  Google Scholar 

  4. Kwong DL, Sham JS, Au GK, Chua DT, Kwong PW, Cheng AC, Wu PM, Law MW, Kwok CC, Yau CC, Wan KY, Chan RT, Choy DD: Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma: a factorial study. J Clin Oncol 2004, 22: 2643-2653. 10.1200/JCO.2004.05.173

    Article  CAS  PubMed  Google Scholar 

  5. Lin JC, Jan JS, Hsu CY, Liang WM, Jiang RS, Wang WY: Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. J Clin Oncol 2003, 21: 631-637. 10.1200/JCO.2003.06.158

    Article  PubMed  Google Scholar 

  6. Wee J, Tan EH, Tai BC, Wong HB, Leong SS, Tan T, Chua ET, Yang E, Lee KM, Fong KW, Tan HS, Lee KS, Loong S, Sethi V, Chua EJ, Machin D: Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 2005, 23: 6730-6738. 10.1200/JCO.2005.16.790

    Article  CAS  PubMed  Google Scholar 

  7. Chau RM, Teo PM, Kam MK, Leung SF, Cheung KY, Chan AT: Dosimetric comparison between 2-dimensional radiation therapy and intensity modulated radiation therapy in treatment of advanced T-stage nasopharyngeal carcinoma: to treat less or more in the planning organ-at-risk volume of the brainstem and spinal cord. Med Dosim 2007, 32: 263-270. 10.1016/j.meddos.2007.02.006

    Article  PubMed  Google Scholar 

  8. Xia P, Fu KK, Wong GW, Akazawa C, Verhey LJ: Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000, 48: 329-337.

    Article  CAS  PubMed  Google Scholar 

  9. Lee N, Harris J, Garden AS, Straube W, Glisson B, Xia P, Bosch W, Morrison WH, Quivey J, Thorstad W, Jones C, Ang KK: Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225. J Clin Oncol 2009, 27: 3684-3690. 10.1200/JCO.2008.19.9109

    Article  PubMed Central  PubMed  Google Scholar 

  10. Peng G, Wang T, Yang KY, Zhang S, Zhang T, Li Q, Han J, Wu G: A prospective, randomized study comparing outcomes and toxicities of intensity-modulated radiotherapy vs. conventional two-dimensional radiotherapy for the treatment of nasopharyngeal carcinoma. Radiother Oncol 2012, 104: 286-293. 10.1016/j.radonc.2012.08.013

    Article  PubMed  Google Scholar 

  11. Wang TJC, Riaz N, Cheng SK, Lu JJ, Lee NY: Intensity-modulated radiation therapy for nasopharyngeal carcinoma: a review. J Radiat Oncol 2012, 1: 129-146. 10.1007/s13566-012-0020-4

    Article  Google Scholar 

  12. Zhang L, Zhao C, Peng PJ, Lu LX, Huang PY, Han F, Wu SX: Phase III study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma: preliminary results. J Clin Oncol 2005, 23: 8461-8468. 10.1200/JCO.2004.00.3863

    Article  CAS  PubMed  Google Scholar 

  13. Zhang L, Zhao C, Ghimire B, Hong MH, Liu Q, Zhang Y, Guo Y, Huang YJ, Guan ZZ: The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase III randomized trials. BMC Cancer 2010, 10: 558. 10.1186/1471-2407-10-558

    Article  PubMed Central  PubMed  Google Scholar 

  14. Chen L, Hu CS, Chen XZ, Hu GQ, Cheng ZB, Sun Y, Li WX, Chen YY, Xie FY, Liang SB, Chen Y, Xu TT, Li B, Long GX, Wang SY, Zheng BM, Guo Y, Mao YP, Tang LL, Chen YM, Liu MZ, Ma J: Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol 2012, 13: 163-171. 10.1016/S1470-2045(11)70320-5

    Article  PubMed  Google Scholar 

  15. Lee AW, Tung SY, Chan AT, Chappell R, Fu YT, Lu TX, Tan T, Chua DT, O'Sullivan B, Tung R, Ng WT, Leung TW, Leung SF, Yau S, Zhao C, Tan EH, Au GK, Siu L, Fung KK, Lau WH: A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma. Radiother Oncol 2011, 98: 15-22. 10.1016/j.radonc.2010.09.023

    Article  PubMed  Google Scholar 

  16. Lee AW, Tung SY, Chua DT, Ngan RK, Chappell R, Tung R, Siu L, Ng WT, Sze WK, Au GK, Law SC, O'Sullivan B, Yau TK, Leung TW, Au JS, Sze WM, Choi CW, Fung KK, Lau JT, Lau WH: Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 2010, 102: 1188-1198. 10.1093/jnci/djq258

    Article  PubMed  Google Scholar 

  17. Lee AW, Tung SY, Ngan RK, Chappell R, Chua DT, Lu TX, Siu L, Tan T, Chan LK, Ng WT, Leung TW, Fu YT, Au GK, Zhao C, O'Sullivan B, Tan EH, Lau WH: Factors contributing to the efficacy of concurrent-adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: combined analyses of NPC-9901 and NPC-9902 Trials. Eur J Cancer 2011, 47: 656-666. 10.1016/j.ejca.2010.10.026

    Article  CAS  PubMed  Google Scholar 

  18. Orlandi E, Palazzi M, Pignoli E, Fallai C, Giostra A, Olmi P: Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer: a review. Crit Rev Oncol Hematol 2010, 73: 111-125. 10.1016/j.critrevonc.2009.03.003

    Article  PubMed  Google Scholar 

  19. Kwong DL, Sham JS, Leung LH, Cheng AC, Ng WM, Kwong PW, Lui WM, Yau CC, Wu PM, Wei W, Au G: Preliminary results of radiation dose escalation for locally advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2006, 64: 374-381. 10.1016/j.ijrobp.2005.07.968

    Article  PubMed  Google Scholar 

  20. Xiao WW, Huang SM, Han F, Wu SX, Lu LX, Lin CG, Deng XW, Lu TX, Cui NJ, Zhao C: Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study. Cancer 2011, 117: 1874-1883. 10.1002/cncr.25754

    Article  CAS  PubMed  Google Scholar 

  21. Lee AW, Sze WM, Au JS, Leung SF, Leung TW, Chua DT, Zee BC, Law SC, Teo PM, Tung SY, Kwong DL, Lau WH: Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int J Radiat Oncol Biol Phys 2005, 61: 1107-1116. 10.1016/j.ijrobp.2004.07.702

    Article  PubMed  Google Scholar 

  22. Yeh SA, Tang Y, Lui CC, Huang YJ, Huang EY: Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 2005, 62: 672-679. 10.1016/j.ijrobp.2004.11.002

    Article  PubMed  Google Scholar 

  23. Yi JL, Gao L, Huang XD, Li SY, Luo JW, Cai WM, Xiao JP, Xu GZ: Nasopharyngeal carcinoma treated by radical radiotherapy alone: Ten-year experience of a single institution. Int J Radiat Oncol Biol Phys 2006, 65: 161-168. 10.1016/j.ijrobp.2005.12.003

    Article  PubMed  Google Scholar 

  24. Lin S, Lu JJ, Han L, Chen Q, Pan J: Sequential chemotherapy and intensity-modulated radiation therapy in the management of locoregionally advanced nasopharyngeal carcinoma: experience of 370 consecutive cases. BMC Cancer 2010, 10: 39. 10.1186/1471-2407-10-39

    Article  PubMed Central  PubMed  Google Scholar 

  25. Wang R, Wu F, Lu H, Wei B, Feng G, Li G, Liu M, Yan H, Zhu J, Zhang Y, Hu K: Definitive intensity-modulated radiation therapy for nasopharyngeal carcinoma: long-term outcome of a multicenter prospective study. J Cancer Res Clin Oncol 2013, 139: 139-145. 10.1007/s00432-012-1313-0

    Article  CAS  PubMed  Google Scholar 

  26. Su SF, Han F, Zhao C, Huang Y, Chen CY, Xiao WW, Li JX, Lu TX: Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy. Chin J Cancer 2011, 30: 565-573. 10.5732/cjc.010.10547

    Article  PubMed Central  PubMed  Google Scholar 

  27. Bentzen SM: Radiobiological considerations in the design of clinical trials. Radiother Oncol 1994, 32: 1-11. 10.1016/0167-8140(94)90443-X

    Article  CAS  PubMed  Google Scholar 

  28. Sze WM, Lee AW, Yau TK, Yeung RM, Lau KY, Leung SK, Hung AW, Lee MC, Chappell R, Chan K: Primary tumor volume of nasopharyngeal carcinoma: prognostic significance for local control. Int J Radiat Oncol Biol Phys 2004, 59: 21-27. 10.1016/j.ijrobp.2003.10.027

    Article  PubMed  Google Scholar 

  29. Teo PM, Leung SF, Tung SY, Zee B, Sham JS, Lee AW, Lau WH, Kwan WH, Leung TW, Chua D, Sze WM, Au JS, Yu KH, Of SK, Kwong D, Yau TK, Law SC, Sze WK, Au G, Chan AT: Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG). Radiother Oncol 2006, 79: 27-33. 10.1016/j.radonc.2006.03.012

    Article  PubMed  Google Scholar 

  30. Lin JC, Liang WM, Jan JS, Jiang RS, Lin AC: Another way to estimate outcome of advanced nasopharyngeal carcinoma–is concurrent chemoradiotherapy adequate? Int J Radiat Oncol Biol Phys 2004, 60: 156-164. 10.1016/j.ijrobp.2004.03.002

    Article  PubMed  Google Scholar 

  31. Espeli V, Zucca E, Ghielmini M, Giannini O, Salatino A, Martucci F, Richetti A: Weekly and 3-weekly cisplatin concurrent with intensity-modulated radiotherapy in locally advanced head and neck squamous cell cancer. Oral Oncol 2012, 48: 266-271. 10.1016/j.oraloncology.2011.10.005

    Article  CAS  PubMed  Google Scholar 

  32. Ho KF, Swindell R, Brammer CV: Dose intensity comparison between weekly and 3-weekly Cisplatin delivered concurrently with radical radiotherapy for head and neck cancer: a retrospective comparison from New Cross Hospital, Wolverhampton, UK. Acta Oncol 2008, 47: 1513-1518. 10.1080/02841860701846160

    Article  CAS  PubMed  Google Scholar 

  33. Kim TH, Ko YH, Lee MA, Kim BS, Chung SR, Yoo IR, Jung CK, Kim YS, Kim MS, Sun DI, Hong YS, Lee KS, Kang JH: Treatment outcome of cisplatin-based concurrent chemoradiotherapy in the patients with locally advanced nasopharyngeal cancer. Cancer Res Treat 2008, 40: 62-70. 10.4143/crt.2008.40.2.62

    Article  PubMed Central  PubMed  Google Scholar 

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We thanks Dr. Ying Hitchcock (HCH) from Huntsman Cancer Hospital, University of Utah for assistance with the preparation of this manuscript.

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Correspondence to Li Gao.

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Competing interest

This manuscript was sponsored by National Natural Science Foundation of China (81172125). Junlin Yi, Xiaodong Huang, Li Gao, Jingwei Luo, Shiping Zhang, Kai Wang, Yuan Qu, Jianping Xiao, Guozhen Xu declare no conflict of interest.

Authors’ contributions

JLY drafted the manuscript, XDH, JWL, SPZ, KW, YQ and JPX participate this study, mainly work for treating patients and data collection. LG and XGZ designed this study. All authors read and approved the final manuscript.

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Yi, J., Huang, X., Gao, L. et al. Intensity-modulated radiotherapy with simultaneous integrated boost for locoregionally advanced nasopharyngeal carcinoma. Radiat Oncol 9, 56 (2014).

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