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  1. To determine the risk factors of severe radiation pneumonitis (RP) after stereotactic body radiation therapy (SBRT) for primary or secondary lung tumors.

    Authors: Hideomi Yamashita, Shino Kobayashi-Shibata, Atsuro Terahara, Kae Okuma, Akihiro Haga, Reiko Wakui, Kuni Ohtomo and Keiichi Nakagawa

    Citation: Radiation Oncology 2010 5:32

    Content type: Research

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  2. Radiation-induced diarrhea is frequently observed during pelvic radiotherapy. This study was performed to determine the ability of a probiotic containing live lactobacillus acidophilus plus bifidobacterium bif...

    Authors: Imjai Chitapanarux, Taned Chitapanarux, Patrinee Traisathit, Sudkaneung Kudumpee, Ekkasit Tharavichitkul and Vicharn Lorvidhaya

    Citation: Radiation Oncology 2010 5:31

    Content type: Research

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  3. A better understanding of the underlying mechanisms of DNA repair after low- and high-LET radiations represents a research priority aimed at improving the outcome of clinical radiotherapy. To date however, our...

    Authors: Veerle Vandersickel, Monica Mancini, Jacobus Slabbert, Emanuela Marras, Hubert Thierens, Gianpaolo Perletti and Anne Vral

    Citation: Radiation Oncology 2010 5:30

    Content type: Research

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  4. Radiation therapy is an important cancer treatment modality in both adjuvant and definitive setting, however, the use of radiation therapy for elective treatment of regional lymph nodes is controversial for pa...

    Authors: Wenjie Sun, Cheng N Leong, Zhen Zhang and Jiade J Lu

    Citation: Radiation Oncology 2010 5:28

    Content type: Research

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  5. To answer the question if and to which extent acute symptoms at the end and/or several weeks after radiotherapy can predict adverse urinary and gastrointestinal long-term quality of life (QoL).

    Authors: Michael Pinkawa, Richard Holy, Marc D Piroth, Karin Fischedick, Sandra Schaar, Dalma Székely-Orbán and Michael J Eble

    Citation: Radiation Oncology 2010 5:27

    Content type: Research

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  6. Radiation pneumonia and subsequent radiation lung fibrosis are major dose-limiting complications for patients undergoing thoracic radiotherapy. Interleukin-6 (IL-6) is a pleiotropic cytokine and plays importan...

    Authors: Toshiyuki Ogata, Hideya Yamazaki, Teruki Teshima, Ayaka Kihara, Yuko Suzumoto, Takehiro Inoue, Norihiro Nishimoto and Nariaki Matsuura

    Citation: Radiation Oncology 2010 5:26

    Content type: Research

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  7. Endothelial cells (EC) in tumor and normal tissue constitute critical radiotherapy targets. MicroRNAs have emerged as master switchers of the cellular transcriptome. Here, we seek to investigate the role of mi...

    Authors: Mechthild Wagner-Ecker, Christian Schwager, Ute Wirkner, Amir Abdollahi and Peter E Huber

    Citation: Radiation Oncology 2010 5:25

    Content type: Research

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  8. Micrometastases of colorectal liver metastases are present in up to 50% of lesions. In this study we sought to determine the threshold dose for local control of occult micrometastases in patients undergoing CT...

    Authors: Max Seidensticker, Peter Wust, Ricarda Rühl, Konrad Mohnike, Maciej Pech, Gero Wieners, Günther Gademann and Jens Ricke

    Citation: Radiation Oncology 2010 5:24

    Content type: Research

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  9. Mucositis is a toxic side effect of anti-cancer treatments and is a major focus in cancer research. Pro-inflammatory cytokines have previously been implicated in the pathophysiology of chemotherapy-induced gas...

    Authors: Zhi Yi Ong, Rachel J Gibson, Joanne M Bowen, Andrea M Stringer, Jocelyn M Darby, Richard M Logan, Ann SJ Yeoh and Dorothy M Keefe

    Citation: Radiation Oncology 2010 5:22

    Content type: Research

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  10. To determine the variation in target delineation of nasopharyngeal carcinoma and the impact of measures to minimize this variation.

    Authors: Coen RN Rasch, Roel JHM Steenbakkers, Isabelle Fitton, Joop C Duppen, Peter JCM Nowak, Frank A Pameijer, Avraham Eisbruch, Johannes HAM Kaanders, Frank Paulsen and Marcel van Herk

    Citation: Radiation Oncology 2010 5:21

    Content type: Research

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  11. Current staging systems have limited ability to adjust optimal therapy in advanced nasopharyngeal carcinoma (NPC). This study aimed to delineate the correlation between tumor volume, treatment outcome and chem...

    Authors: Ching-Chih Lee, Tze-Ta Huang, Moon-Sing Lee, Shih-Hsuan Hsiao, Hon-Yi Lin, Yu-Chieh Su, Feng-Chun Hsu and Shih-Kai Hung

    Citation: Radiation Oncology 2010 5:20

    Content type: Research

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  12. To study the set-up errors, PTV margin and toxicity of cone beam CT (CBCT) guided hypofractionated radiotherapy with active breathing control (ABC) for patients with non-small cell lung cancer (NSCLC) or metas...

    Authors: Yali Shen, Hong Zhang, Jin Wang, Renming Zhong, Xiaoqing Jiang, Qinfeng Xu, Xin Wang, Sen Bai and Feng Xu

    Citation: Radiation Oncology 2010 5:19

    Content type: Research

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  13. Giant cell tumors are rare neoplasms, representing less than 5% of all bone tumors. The vast majority of giant cell tumors occurs in extremity sites and is treated by surgery alone. However, a small percentage...

    Authors: Falk Roeder, Carmen Timke, Felix Zwicker, Christian Thieke, Marc Bischof, Jürgen Debus and Peter E Huber

    Citation: Radiation Oncology 2010 5:18

    Content type: Research

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  14. To compare target dose distribution, comformality, normal tissue avoidance, and irradiated body volume (IBV) in 3DCRT using classic anatomical landmarks (c3DCRT), 3DCRT fitting the PTV (f3DCRT), and intensity-...

    Authors: Leire Arbea, Luis Isaac Ramos, Rafael Martínez-Monge, Marta Moreno and Javier Aristu

    Citation: Radiation Oncology 2010 5:17

    Content type: Methodology

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  15. The purpose of this pilot study was to detect a correlation between serum cytokine levels and severity of mucositis, necessitating installation of a percutaneous endoscopic gastrostomy tube (PEG) in head and n...

    Authors: Amichay Meirovitz, Michal Kuten, Salem Billan, Roxolyana Abdah-Bortnyak, Anat Sharon, Tamar Peretz, Mordechai Sela, Moshe Schaffer and Vivian Barak

    Citation: Radiation Oncology 2010 5:16

    Content type: Research

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  16. In recent years data from both mouse models and human tumors suggest that loss of one allele of genes involved in DNA repair pathways may play a central role in genomic instability and carcinogenesis. Addition...

    Authors: Fengtao Su, Lubomir B Smilenov, Thomas Ludwig, Libin Zhou, Jiayun Zhu, Guangming Zhou and Eric J Hall

    Citation: Radiation Oncology 2010 5:15

    Content type: Research

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  17. To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc® (RA) technology.

    Authors: Antonella Richetti, Antonella Fogliata, Alessandro Clivio, Giorgia Nicolini, Gianfranco Pesce, Emanuela Salati, Eugenio Vanetti and Luca Cozzi

    Citation: Radiation Oncology 2010 5:14

    Content type: Research

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  18. To determine the outcome of patients with brain metastasis (BM) from lung cancer treated with an external beam radiotherapy boost (RTB) after whole brain radiotherapy (WBRT).

    Authors: Nathalie Casanova, Zohra Mazouni, Sabine Bieri, Christophe Combescure, Alessia Pica and Damien C Weber

    Citation: Radiation Oncology 2010 5:13

    Content type: Research

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  19. Three-dimensional conformal radiation therapy (3DCRT)/intensity-modulated radiation therapy (IMRT) combined with or without transcatheter arterial chemoembolization (TACE) for locally advanced hepatocellular c...

    Authors: Jian-Dong Zhao, Jin Liu, Zhi-Gang Ren, Ke Gu, Zhen-Hua Zhou, Wen-Tao Li, Zhen Chen, Zhi-Yong Xu, Lu-Ming Liu and Guo-Liang Jiang

    Citation: Radiation Oncology 2010 5:12

    Content type: Study protocol

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  20. Instable and painful vertebral metastases in patients with progressive visceral metastases present a common therapeutic dilemma. We developed a novel approach to deliver intraoperative radiotherapy (IORT) duri...

    Authors: Frederik Wenz, Frank Schneider, Christian Neumaier, Uta Kraus-Tiefenbacher, Tina Reis, René Schmidt and Udo Obertacke

    Citation: Radiation Oncology 2010 5:11

    Content type: Methodology

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  21. FDG-PET/CT imaging has an emerging role in staging and treatment planning of various tumor locations and a number of literature studies show that also the carcinoma of the anal canal may benefit from this diag...

    Authors: Marco Krengli, Maria E Milia, Lucia Turri, Eleonora Mones, Maria C Bassi, Barbara Cannillo, Letizia Deantonio, Gianmauro Sacchetti, Marco Brambilla and Eugenio Inglese

    Citation: Radiation Oncology 2010 5:10

    Content type: Research

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  22. A fourteen years-old boy was treated post-operatively with proton therapy for a recurrent low-grade oligodendroglioma located in the tectal region. Six months after the end of irradiation (RT), a new enhancing...

    Authors: Candice Meyzer, Frédéric Dhermain, Denis Ducreux, Jean-Louis Habrand, Pascale Varlet, Christian Sainte-Rose, Christelle Dufour and Jacques Grill

    Citation: Radiation Oncology 2010 5:9

    Content type: Case report

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  23. The histamine receptor-1 (H1)-antagonist, loratadine has been shown to inhibit growth of human colon cancer xenografts in part due to cell cycle arrest in G2/M. Since this is a radiation sensitive phase of the...

    Authors: Benjamin P Soule, Nicole L Simone, William G DeGraff, Rajani Choudhuri, John A Cook and James B Mitchell

    Citation: Radiation Oncology 2010 5:8

    Content type: Research

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  24. Castleman disease (CD) is a rare benign disorder characterised by hyperplasia of lymphoid tissue that may develop at a single site or throughout the body. The etiology of this disorder is unclear, although the...

    Authors: Iris AC de Vries, Marjolein MS van Acht, Thomas BJ Demeyere, Marnix LM Lybeert, Jean-Paul de Zoete and Grard AP Nieuwenhuijzen

    Citation: Radiation Oncology 2010 5:7

    Content type: Case report

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  25. Sublethal doses of whole brain irradiation (WBI) are commonly administered therapeutically and frequently result in late delayed radiation injuries, manifesting as severe and irreversible cognitive impairment....

    Authors: Kenneth A Jenrow, Stephen L Brown, Jianguo Liu, Andrew Kolozsvary, Karen Lapanowski and Jae Ho Kim

    Citation: Radiation Oncology 2010 5:6

    Content type: Research

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  26. FLAIR and T2 weighted MRIs are used based on institutional preference to delineate high grade gliomas and surrounding edema for radiation treatment planning. Although these sequences have inherent physical dif...

    Authors: Bronwyn Stall, Leor Zach, Holly Ning, John Ondos, Barbara Arora, Uma Shankavaram, Robert W Miller, Deborah Citrin and Kevin Camphausen

    Citation: Radiation Oncology 2010 5:5

    Content type: Research

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  27. Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictiv...

    Authors: Elisa Bordón, Luis Alberto Henríquez-Hernández, Pedro C Lara, Ana Ruíz, Beatriz Pinar, Carlos Rodríguez-Gallego and Marta Lloret

    Citation: Radiation Oncology 2010 5:4

    Content type: Short report

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  28. To assess the accuracy of fractionated stereotactic radiotherapy (FSRT) using a stereotactic mask fixation system.

    Authors: Giuseppe Minniti, Maurizio Valeriani, Enrico Clarke, Marco D'Arienzo, Michelangelo Ciotti, Roberto Montagnoli, Francesca Saporetti and Riccardo Maurizi Enrici

    Citation: Radiation Oncology 2010 5:1

    Content type: Methodology

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  29. The spine is the most common site for bone metastases. Radiation therapy is a common treatment for palliation of pain and for prevention or treatment of spinal cord compression. Helical tomotherapy (HT), a new...

    Authors: Pei-Wei Shueng, Shih-Chiang Lin, Hou-Tai Chang, Ngot-Swan Chong, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh and Chen-Hsi Hsieh

    Citation: Radiation Oncology 2009 4:71

    Content type: Case report

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  30. Accurate localisation of the lumpectomy cavity (LC) volume is one of the most critical points in 3D-conformal Partial breast irradiation (3D-APBI) treatment planning because the irradiated volume is restricted...

    Authors: Maia Dzhugashvili, Elodie Tournay, Charlotte Pichenot, Ariane Dunant, Eduardo Pessoa, Adel Khallel, Sébastien Gouy, Catherine Uzan, Jean-Rémy Garbay, Françoise Rimareix, Marc Spielmann, Philippe Vielh, Hugo Marsiglia and Céline Bourgier

    Citation: Radiation Oncology 2009 4:70

    Content type: Research

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  31. Glioblastoma multiforme (GBM) is resistant to current cytotoxic therapies, in part because of enhanced DNA repair. Activation of the receptor tyrosine kinase c-Met has been shown to protect cancer cells from D...

    Authors: James W Welsh, Daruka Mahadevan, Ron Ellsworth, Laurence Cooke, David Bearss and Baldassarre Stea

    Citation: Radiation Oncology 2009 4:69

    Content type: Research

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  32. To evaluate clinical outcome after preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy and adjuvant chemotherapy for pathological stage UICC ≥...

    Authors: Matthias Guckenberger, Joern Wulf, Andreas Thalheimer, Daniel Wehner, Arnulf Thiede, Gottfried Müller, Marco Sailer and Michael Flentje

    Citation: Radiation Oncology 2009 4:67

    Content type: Research

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  33. We have previously shown that small molecule PDGF receptor tyrosine kinase inhibitors (RTKI) can drastically attenuate radiation-induced pulmonary fibrosis if the drug administration starts at the time of radi...

    Authors: Minglun Li, Amir Abdollahi, Hermann-Josef Gröne, Kenneth E Lipson, Claus Belka and Peter E Huber

    Citation: Radiation Oncology 2009 4:66

    Content type: Research

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  34. We regret to report that a proofreading error caused an incorrect legend and description of the contents of table 6 to appear in our original publication of this work. The correct description of table 6 is: Un...

    Authors: Jarad M Martin, Andrew Bayley, Robert Bristow, Peter Chung, Mary Gospodarowicz, Cynthia Menard, Michael Milosevic, Tara Rosewall, Padraig R Warde and Charles N Catton

    Citation: Radiation Oncology 2009 4:65

    Content type: Erratum

    Published on:

    The original article was published in Radiation Oncology 2009 4:50

  35. Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify...

    Authors: Yusei Fujita, Itsuro Kato, Soichi Iwai, Koji Ono, Minoru Suzuki, Yoshinori Sakurai, Ken Ohnishi, Takeo Ohnishi and Yoshiaki Yura

    Citation: Radiation Oncology 2009 4:63

    Content type: Research

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  36. To review the experience and to evaluate the treatment plan of using helical tomotherapy (HT) for the treatment of cervical cancer.

    Authors: Chen-Hsi Hsieh, Ming-Chow Wei, Hsing-Yi Lee, Sheng-Mou Hsiao, Chien-An Chen, Li-Ying Wang, Yen-Ping Hsieh, Tung-Hu Tsai, Yu-Jen Chen and Pei-Wei Shueng

    Citation: Radiation Oncology 2009 4:62

    Content type: Research

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  37. In locally advanced rectal cancer, 5-Fluorouracil (5-FU)-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties...

    Authors: Adalsteinn Gunnlaugsson, Per Nilsson, Elisabeth Kjellén and Anders Johnsson

    Citation: Radiation Oncology 2009 4:61

    Content type: Research

    Published on:

  38. Primary orbital lymphoma is a rare disease that accounts for 10% of all orbital tumors. Radiotherapy on the orbital cavity is the treatment of choice for this unusual presentation of localized non-Hodgkin's ly...

    Authors: Luigi De Cicco, Laura Cella, Raffaele Liuzzi, Raffaele Solla, Antonio Farella, Giorgio Punzo, Fausto Tranfa, Diego Strianese, Manuel Conson, Giulio Bonavolontà, Marco Salvatore and Roberto Pacelli

    Citation: Radiation Oncology 2009 4:60

    Content type: Research

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  39. The underlying molecular and cellular mechanisms of radiation pneumonitis (RP) are very complex. Several biological factors need to be considered together with the well known dosimetric parameters for understa...

    Authors: Ji-Yoon Kim, Yeon-Sil Kim, Young-Kyoon Kim, Hyun-Jin Park, Seung-Joon Kim, Jin-Hyoung Kang, Young-Pil Wang, Hong-Seok Jang, Sang-Nam Lee and Sei-Chul Yoon

    Citation: Radiation Oncology 2009 4:59

    Content type: Research

    Published on:

  40. Cervical cancer is treated mainly by surgery and radiotherapy. Toxicity due to radiation is a limiting factor for treatment success. Determination of lymphocyte radiosensitivity by radio-induced apoptosis aris...

    Authors: Elisa Bordón, Luis Alberto Henríquez Hernández, Pedro C Lara, Beatriz Pinar, Fausto Fontes, Carlos Rodríguez Gallego and Marta Lloret

    Citation: Radiation Oncology 2009 4:58

    Content type: Research

    Published on:

  41. Biological brain tumor imaging using O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET combined with inverse treatment planning for locally restricted dose escalation in patients with glioblastoma multiforme seems to b...

    Authors: Marc D Piroth, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Cengiz Demirel, Charbel Attieh, Hans J Kaiser, Karl J Langen and Michael J Eble

    Citation: Radiation Oncology 2009 4:57

    Content type: Research

    Published on:

  42. The observation that human meningioma cells strongly express somatostatin receptor (SSTR 2) was the rationale to analyze retrospectively in how far DOTATOC PET/CT is helpful to improve target volume delineatio...

    Authors: Barbara Gehler, Frank Paulsen, Mehmet Ö Öksüz, Till-Karsten Hauser, Susanne M Eschmann, Roland Bares, Christina Pfannenberg, Michael Bamberg, Peter Bartenstein, Claus Belka and Ute Ganswindt

    Citation: Radiation Oncology 2009 4:56

    Content type: Research

    Published on:

  43. Reirradiation to the abdomen could potentially play a role in palliation of symptoms or local control in patients with gastrointestinal malignancies. Our goal was to retrospectively determine rates of toxicity...

    Authors: Waqar Haque, Christopher H Crane, Sunil Krishnan, Marc E Delclos, Milind Javle, Christopher R Garrett, Robert A Wolff and Prajnan Das

    Citation: Radiation Oncology 2009 4:55

    Content type: Short report

    Published on:

  44. In the present work we compared the spatial uncertainties associated with a MR-based workflow for external radiotherapy of prostate cancer to a standard CT-based workflow. The MR-based workflow relies on targe...

    Authors: Tufve Nyholm, Morgan Nyberg, Magnus G Karlsson and Mikael Karlsson

    Citation: Radiation Oncology 2009 4:54

    Content type: Research

    Published on:

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