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  1. The purpose of this study was to investigate the impact of histology on survival stratified by the Graded Prognostic Assessment (GPA) for non-small cell lung cancer (NSCLC) in a group of selected patients trea...

    Authors: Liang-Hua Ma, Guang Li, Hong-Wei Zhang, Zhi-Yu Wang, Jun Dang, Shuo Zhang and Lei Yao
    Citation: Radiation Oncology 2016 11:92
    Content type: Research Published on:

  2. Biological applications of nanoparticles are rapidly increasing, which introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized titanium peroxide nanoparticles (TiOxNPs) and i...

    Authors: Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami and Akihiko Kondo
    Citation: Radiation Oncology 2016 11:91
    Content type: Research Published on:

  3. To evaluate the use of high-dose radiotherapy using carbon ions (C12) on non-adenoid cystic malignant salivary gland tumors (MSGT).

    Authors: A. D. Jensen, M. Poulakis, V. Vanoni, M. Uhl, N. Chaudhri, P. A. Federspil, K. Freier, J. Krauss and J. Debus
    Citation: Radiation Oncology 2016 11:90
    Content type: Research Published on:

  4. Few data are available on the tolerance of reirradiation in patients with hepatocellular carcinoma (HCC). This study determined the clinical parameters contributing to the development of radiation-induced live...

    Authors: Yaoru Huang, Shang-Wen Chen, Ching-Chao Fan, Lai-Lei Ting, Chia-Chun Kuo and Jeng-Fong Chiou
    Citation: Radiation Oncology 2016 11:89
    Content type: Research Published on:

  5. Fiducial markers are the superior method to compensate for interfractional motion in liver SBRT. However this method is invasive and thereby limits its application range. In this retrospective study, the compe...

    Authors: Christian Heinz, Sabine Gerum, Philipp Freislederer, Ute Ganswindt, Falk Roeder, Stefanie Corradini, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2016 11:88
    Content type: Research Published on:

  6. O-(2-18 F-fluoroethyl)-L-tyrosine-(FET)-PET may be helpful to improve the definition of radiation target volumes in glioblastomas compared with MRI. We analyzed the relapse patterns in FET-PET after a FET- and...

    Authors: Marc D. Piroth, Norbert Galldiks, Michael Pinkawa, Richard Holy, Gabriele Stoffels, Johannes Ermert, Felix M. Mottaghy, N. Jon Shah, Karl-Josef Langen and Michael J. Eble
    Citation: Radiation Oncology 2016 11:87
    Content type: Research Published on:

  7. Recent studies suggest that radiation-induced injuries to the hippocampus play important roles in compromising neurocognitive functioning for patients with brain tumors and it could be important to spare the h...

    Authors: Megumi Uto, Takashi Mizowaki, Kengo Ogura and Masahiro Hiraoka
    Citation: Radiation Oncology 2016 11:86
    Content type: Research Published on:

  9. Multimodality treatment is widely performed for clinical T1N0M0 (UICC-TNM classification, 7th edition) thoracic esophageal squamous cell carcinoma (ESCC), but available articles regarding treatment results are...

    Authors: Yusuke Uchinami, Miyako Myojin, Hiroaki Takahashi, Keiichi Harada, Shinichi Shimizu and Masao Hosokawa
    Citation: Radiation Oncology 2016 11:84
    Content type: Research Published on:

  10. A challenge preventing routine clinical implementation of Monte Carlo (MC)-based lung SBRT is the difficulty of reinterpreting historical outcome data calculated with inaccurate dose algorithms, because the ta...

    Authors: Dandan Zheng, Xiaofeng Zhu, Qinghui Zhang, Xiaoying Liang, Weining Zhen, Chi Lin, Vivek Verma, Shuo Wang, Andrew Wahl, Yu Lei, Sumin Zhou and Chi Zhang
    Citation: Radiation Oncology 2016 11:83
    Content type: Research Published on:

  11. The aim of this study was to experimentally assess the dosimetric impact of leaf interdigitation using different inverse treatment strategies for representative tumour sites and to identify the situations in w...

    Authors: Jinghao Duan, Xiangjuan Meng, Tonghai Liu and Yong Yin
    Citation: Radiation Oncology 2016 11:82
    Content type: Research Published on:

  12. A sweeping beam technique for total body irradiation in standard treatment rooms and for standard linear accelerators (linacs) is introduced, which does not require any accessory attached to the linac. Lung sh...

    Authors: Petra M. Härtl, Marius Treutwein, Matthias G. Hautmann, Manuel März, Fabian Pohl, Oliver Kölbl and Barbara Dobler
    Citation: Radiation Oncology 2016 11:81
    Content type: Research Published on:

  13. Stereotactic body radiotherapy (SBRT) using flattening filter free (FFF)-techniques has been increasingly applied during the last years. However, clinical studies investigating this emerging technique are stil...

    Authors: Juliane Rieber, Eric Tonndorf-Martini, Oliver Schramm, Bernhard Rhein, Laila König, Sebastian Adeberg, Eva Meyerhof, Angela Mohr, Jutta Kappes, Hans Hoffmann, Jürgen Debus and Stefan Rieken
    Citation: Radiation Oncology 2016 11:80
    Content type: Research Published on:

  14. To generate a nomogram to predict parotid gland (PG) overdose and to quantify the dosimetric benefit of weekly replanning based on its findings, in the context of intensity-modulated radiotherapy (IMRT) for lo...

    Authors: J. Castelli, A. Simon, B. Rigaud, C. Lafond, E. Chajon, J. D. Ospina, P. Haigron, B. Laguerre, A. Ruffier Loubière, K. Benezery and R. de Crevoisier
    Citation: Radiation Oncology 2016 11:79
    Content type: Research Published on:

  15. to evaluate the role of a risk stratification system in intermediate-risk prostate cancer (PCa) treated with hypofractionated radiotherapy (HyRT).

    Authors: Stefano Bracci, Mattia F. Osti, Linda Agolli, Luca Bertaccini, Vitaliana De Sanctis and Maurizio Valeriani
    Citation: Radiation Oncology 2016 11:78
    Content type: Research Published on:

  16. Experimental data demonstrated that concurrent anti-angiogenic treatment with sunitinib may improve the efficacy of radiation therapy (RT). Here we report the results of a phase I trial performed within the Ge...

    Authors: Jens Jakob, Anna Simeonova, Bernd Kasper, Ulrich Ronellenfitsch, Geraldine Rauch, Frederik Wenz and Peter Hohenberger
    Citation: Radiation Oncology 2016 11:77
    Content type: Research Published on:

  17. Hypo-fractionated stereotactic radiotherapy (HSRT) is emerging as a valid treatment option for patients with single, large brain metastases (BMs). We analyzed a set of our patients treated with HSRT. The aim o...

    Authors: Pierina Navarria, Federico Pessina, Luca Cozzi, Anna Maria Ascolese, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Davide Franceschini, Angelo Tozzi, Giuseppe D’Agostino, Tiziana Comito, Cristina Iftode, Giulia Maggi, Giacomo Reggiori, Lorenzo Bello and Marta Scorsetti
    Citation: Radiation Oncology 2016 11:76
    Content type: Research Published on:

  18. Unsaturated fatty acids (FA) are required for cancer cell growth. In normoxia cells can generate unsaturated FA from saturated stearic and palmitic acid by desaturation. However, since the desaturation step is...

    Authors: Johann Matschke, Elisa Wiebeck, Sebastian Hurst, Justine Rudner and Verena Jendrossek
    Citation: Radiation Oncology 2016 11:75
    Content type: Research Published on:

  19. We retrospectively evaluated the efficacy and toxicity of gross tumor volume (GTV) mean-dose-optimized and real-time motion-compensated robotic stereotactic body radiation therapy (SBRT) in the treatment of li...

    Authors: Nicolaus Andratschke, Alan Parys, Susanne Stadtfeld, Stefan Wurster, Stefan Huttenlocher, Detlef Imhoff, Müjdat Yildirim, Dirk Rades, Claus Michael Rödel, Jürgen Dunst, Guido Hildebrandt and Oliver Blanck
    Citation: Radiation Oncology 2016 11:74
    Content type: Research Published on:

  20. Prostate cancer (PC) is one of the most commonly treated cancer entities with radiation therapy (RT). Risk group-adapted treatment and avoidance of unnecessary toxicities relies primarily on accurate tumor sta...

    Authors: Sabrina Dewes, Kilian Schiller, Katharina Sauter, Matthias Eiber, Tobias Maurer, Markus Schwaiger, Jürgen E. Gschwend, Stephanie E. Combs and Gregor Habl
    Citation: Radiation Oncology 2016 11:73
    Content type: Research Published on:

  21. Renal atrophy is observed in an irradiated kidney. The aim of this study was to determine dose-volume histogram parameters and other factors that predict renal atrophy after 10-fraction stereotactic body radio...

    Authors: Takaya Yamamoto, Noriyuki Kadoya, Ken Takeda, Haruo Matsushita, Rei Umezawa, Kiyokazu Sato, Masaki Kubozono, Kengo Ito, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yu Katagiri, Hiroshi Onishi and Keiichi Jingu
    Citation: Radiation Oncology 2016 11:72
    Content type: Research Published on:

  22. The effects of spinal implants on dose distribution have been studied for conformal treatment plans. However, the dosimetric impact of spinal implants in stereotactic body radiotherapy (SBRT) treatments has no...

    Authors: Gozde Yazici, Sezin Yuce Sari, Fazli Yagiz Yedekci, Altug Yucekul, Sumerya Duru Birgi, Gokhan Demirkiran, Melis Gultekin, Pervin Hurmuz, Muharrem Yazici, Gokhan Ozyigit and Mustafa Cengiz
    Citation: Radiation Oncology 2016 11:71
    Content type: Research Published on:

  23. Hyperfractionated (HFRT) or accelerated hyperfractionated radiotherapy (AHFRT) have been discussed as a potential treatment for glioblastoma based on a hypothesized reduction of late radiation injury and preve...

    Authors: David Kaul, Julian Florange, Harun Badakhshi, Arne Grün, Pirus Ghadjar, Sebastian Exner and Volker Budach
    Citation: Radiation Oncology 2016 11:70
    Content type: Research Published on:

  25. In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, biological experiments have evidenced RBE dependencies on dose level, proton linear energy tra...

    Authors: Giulia Giovannini, Till Böhlen, Gonzalo Cabal, Julia Bauer, Thomas Tessonnier, Kathrin Frey, Jürgen Debus, Andrea Mairani and Katia Parodi
    Citation: Radiation Oncology 2016 11:68
    Content type: Research Published on:

  26. To study the dose-response of stage I non-small-cell lung cancer (NSCLC) in terms of long-term local tumor control (LC) after conventional and hypofractionated photon radiotherapy, modeled with the linear-quad...

    Authors: Alina Santiago, Steffen Barczyk, Urszula Jelen, Rita Engenhart-Cabillic and Andrea Wittig
    Citation: Radiation Oncology 2016 11:67
    Content type: Research Published on:

  27. To establish the feasibility of the dosimetric compliance criteria of the RTOG 1308 trial through testing against Intensity Modulation Radiation Therapy (IMRT) and Passive Scattering Proton Therapy (PSPT) plans.

    Authors: Tawfik Giaddui, Wenzhou Chen, Jialu Yu, Liyong Lin, Charles B. Simone II, Lulin Yuan, Yutao U. T. Gong, Q. Jackie Wu, Radhe Mohan, Xiaodong Zhang, Jaques B. Bluett, Michael Gillin, Kevin Moore, Elizabeth O’Meara, Jennifer Presley, Jeffrey D. Bradley…
    Citation: Radiation Oncology 2016 11:66
    Content type: Research Published on:

  28. Here we evaluate the current status of clinical research on regional hyperthermia (RHT) in combination with chemotherapy or radiation therapy in paediatric oncology.

    Authors: Georg Seifert, Volker Budach, Ulrich Keilholz, Peter Wust, Angelika Eggert and Pirus Ghadjar
    Citation: Radiation Oncology 2016 11:65
    Content type: Review Published on:

  29. Intensity modulated proton therapy (IMPT) of head and neck (H&N) tumors may benefit from plan adaptation to correct for the dose perturbations caused by weight loss and tumor volume changes observed in these p...

    Authors: Christopher Kurz, Reinoud Nijhuis, Michael Reiner, Ute Ganswindt, Christian Thieke, Claus Belka, Katia Parodi and Guillaume Landry
    Citation: Radiation Oncology 2016 11:64
    Content type: Research Published on:

  30. Dynamic Wave Arc (DWA) is a clinical approach designed to maximize the versatility of Vero SBRT system by synchronizing the gantry-ring noncoplanar movement with D-MLC optimization. The purpose of this study w...

    Authors: Manuela Burghelea, Dirk Verellen, Kenneth Poels, Cecilia Hung, Mitsuhiro Nakamura, Jennifer Dhont, Thierry Gevaert, Robbe Van den Begin, Christine Collen, Yukinori Matsuo, Takahiro Kishi, Viorica Simon, Masahiro Hiraoka and Mark de Ridder
    Citation: Radiation Oncology 2016 11:63
    Content type: Methodology Published on:

  31. Nasopharyngeal carcinoma (NPC) is most common in Southeast Asia. The purpose of this study is to investigate the correlation between wait time and length of radiotherapy and overall survival (OS) of NPC patien...

    Authors: Po-Chun Chen, Wen-Shan Liu, Wei-Lun Huang, Cheng-Jung Wu, Ching-Chieh Yang and Ching-Chih Lee
    Citation: Radiation Oncology 2016 11:62
    Content type: Research Published on:

  32. Risk of normal tissue toxicity limits the amount of thoracic radiation therapy (RT) that can be routinely prescribed to treat non-small cell lung cancer (NSCLC). An early biomarker of response to thoracic RT m...

    Authors: Tru-Khang T. Dinh, Wojciech Fendler, Justyna Chałubińska-Fendler, Sanket S. Acharya, Colin O’Leary, Peter V. Deraska, Alan D. D’Andrea, Dipanjan Chowdhury and David Kozono
    Citation: Radiation Oncology 2016 11:61
    Content type: Research Published on:

  33. The combination of dendritic cells (DCs) and cytokine-induced killer cells (CIKs) can induce the anti-tumor immune response and radiotherapy may promote the activity. We aimed to explore the feasibility of DCs...

    Authors: Luping Zhang, Yanmei Xu, Jie Shen, Feng He, Dan Zhang, Zhengtang Chen, Yuzhong Duan and Jianguo Sun
    Citation: Radiation Oncology 2016 11:60
    Content type: Research Published on:

  34. To compare and evaluate the possible advantages related to the use of VMAT and helical IMRT and two different modalities of boost delivering, adjuvant stereotactic boost (SRS) or simultaneous integrated boost ...

    Authors: Paolo Borghetti, Sara Pedretti, Luigi Spiazzi, Rossella Avitabile, Mauro Urpis, Federica Foscarini, Giulia Tesini, Francesca Trevisan, Paolo Ghirardelli, Sara Angela Pandini, Luca Triggiani, Stefano Maria Magrini and Michela Buglione
    Citation: Radiation Oncology 2016 11:59
    Content type: Research Published on:

  35. Benign tumors of the skull base are a challenge when delivering radiotherapy. An appropriate choice of radiation technique may significantly improve the patient’s outcomes. Our study aimed to compare the dosim...

    Authors: Fanny Martin, Florian Magnier, Lucie Berger, Jessica Miroir, Emmanuel Chautard, Pierre Verrelle, Michel Lapeyre and Julian Biau
    Citation: Radiation Oncology 2016 11:58
    Content type: Research Published on:

  36. The aim of this study was to quantify the variability in spinal radiosurgery (SRS) planning practices between five international institutions, all member of the Elekta Spine Radiosurgery Research Consortium.

    Authors: André Toussaint, Anne Richter, Frederick Mantel, John C. Flickinger, Inga Siiner Grills, Neelam Tyagi, Arjun Sahgal, Daniel Letourneau, Jason P. Sheehan, David J. Schlesinger, Peter Carlos Gerszten and Matthias Guckenberger
    Citation: Radiation Oncology 2016 11:57
    Content type: Research Published on:

  37. The purpose of this study is to retrospectively evaluate the incidence of lung toxicities after proton beam therapy (PBT) in patients with idiopathic pulmonary fibrosis (IPF).

    Authors: Takashi Ono, Masato Hareyama, Tatsuya Nakamura, Kanako Kimura, Yuichiro Hayashi, Yusuke Azami, Katsumi Hirose, Yoshiomi Hatayama, Motohisa Suzuki, Hitoshi Wada, Yasuhiro Kikuchi and Kenji Nemoto
    Citation: Radiation Oncology 2016 11:56
    Content type: Research Published on:

  38. We reviewed outcomes of patients with loco-regionally recurrent (LRR) or new primary (NP) squamous cell carcinoma of the head and neck (SCCHN) treated at our institution with reirradiation (RRT).

    Authors: Kelly K. Curtis, Helen J. Ross, Ashley L. Garrett, Theresa A. Jizba, Ajay B. Patel, Samir H. Patel, William W. Wong, Michele Y. Halyard, Stephen J. Ko, Heidi E. Kosiorek and Robert L. Foote
    Citation: Radiation Oncology 2016 11:55
    Content type: Research Published on:

  39. Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring card...

    Authors: Sophie Jacob, Atul Pathak, Denis Franck, Igor Latorzeff, Gaelle Jimenez, Olivier Fondard, Matthieu Lapeyre, Daniel Colombier, Eric Bruguiere, Olivier Lairez, Benoit Fontenel, Fabien Milliat, Radia Tamarat, David Broggio, Sylvie Derreumaux, Marianne Ducassou…
    Citation: Radiation Oncology 2016 11:54
    Content type: Study protocol Published on:

  40. While intensity modulated radiotherapy (IMRT) in anal cancer is feasible and improves high-dose conformality, the current RTOG/AGITG contouring atlas and planning guidelines lack specific instructions on how t...

    Authors: Julia Koeck, Frank Lohr, Daniel Buergy, Karen Büsing, Marcus J. Trunk, Frederik Wenz and Sabine Mai
    Citation: Radiation Oncology 2016 11:53
    Content type: Research Published on:

  41. This study investigates the implementation of a new intensity modulated arc therapy (IMAT) class solution in comparison to a 6-static beam step-and-shoot intensity modulated radiotherapy (s-IMRT) for three-pha...

    Authors: Dieter Berwouts, Luiza Ana Maria Olteanu, Bruno Speleers, Frédéric Duprez, Indira Madani, Tom Vercauteren, Wilfried De Neve and Werner De Gersem
    Citation: Radiation Oncology 2016 11:52
    Content type: Research Published on:

  42. Glioblastomas progress rapidly making response evaluation using MRI insufficient since treatment effects are not detectable until months after initiation of treatment. Thus, there is a strong need for suppleme...

    Authors: Lina Mörén, Carl Wibom, Per Bergström, Mikael Johansson, Henrik Antti and A. Tommy Bergenheim
    Citation: Radiation Oncology 2016 11:51
    Content type: Research Published on:

  43. Preoperative chemoradiotherapy (CRT) has become a widely used treatment for improving local control of disease and increasing survival rates of rectal cancer patients. We aimed to identify a set of genes that ...

    Authors: Jungsoo Gim, Yong Beom Cho, Hye Kyung Hong, Hee Cheol Kim, Seong Hyeon Yun, Hong-Gyun Wu, Seung-Yong Jeong, Je-Gun Joung, Taesung Park, Woong-Yang Park and Woo Yong Lee
    Citation: Radiation Oncology 2016 11:50
    Content type: Research Published on:

  44. During a fraction of external beam radiotherapy for prostate cancer, a mismatch between target volume and dose coverage may accumulate over time due to intra-fraction motion. One way to remove the residual err...

    Authors: Hendrik Ballhausen, Ute Ganswindt, Claus Belka and Minglun Li
    Citation: Radiation Oncology 2016 11:49
    Content type: Short report Published on:

    The Data Descriptor to this article has been published in Scientific Data 2019 6:269

  45. To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures.

    Authors: Nikola Cihoric, Alexandros Tsikkinis, Cristina Gutierrez Miguelez, Vratislav Strnad, Ivan Soldatovic, Pirus Ghadjar, Branislav Jeremic, Alan Dal Pra, Daniel M. Aebersold and Kristina Lössl
    Citation: Radiation Oncology 2016 11:48
    Content type: Research Published on:

  46. To compare the long-term outcomes in patients with salivary gland adenoid cystic carcinoma (SGACC) treated with post-operative chemoradiotherapy (POCRT) versus post-operative radiotherapy (PORT).

    Authors: Cheng-En Hsieh, Chien-Yu Lin, Li-Yu Lee, Lan-Yan Yang, Chun-Chieh Wang, Hung-Ming Wang, Joseph Tung-Chieh Chang, Kang-Hsing Fan, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang and Yan-Ming Tsang
    Citation: Radiation Oncology 2016 11:47
    Content type: Research Published on:

  47. To implement total body irradiation (TBI) using volumetric modulated arc therapy (VMAT). We applied the Varian RapidArc™ software to calculate and optimize the dose distribution. Emphasis was placed on applyin...

    Authors: Andreas Springer, Josef Hammer, Erwin Winkler, Christine Track, Roswitha Huppert, Alexandra Böhm, Hedwig Kasparu, Ansgar Weltermann, Gregor Aschauer, Andreas L. Petzer, Ernst Putz, Alexander Altenburger, Rainer Gruber, Karin Moser, Karin Wiesauer and Hans Geinitz
    Citation: Radiation Oncology 2016 11:46
    Content type: Methodology Published on:

  48. For elderly or medically unfit patients with muscle-invasive bladder cancer, cystectomy or chemotherapy are contraindicated. This leaves radical radiotherapy as the only treatment option. It was the aim of thi...

    Authors: Lotte J. Lutkenhaus, Rob M. van Os, Arjan Bel and Maarten C. C. M. Hulshof
    Citation: Radiation Oncology 2016 11:45
    Content type: Research Published on:

  49. Treatment of recurrent gynecologic cancer is a challenging issue. Aim of the study was to investigate clinical features and outcomes of patients with recurrent gynecologic malignancies who underwent resection ...

    Authors: Nathalie Arians, Robert Foerster, Joachim Rom, Matthias Uhl, Falk Roeder, Jürgen Debus and Katja Lindel
    Citation: Radiation Oncology 2016 11:44
    Content type: Research Published on:

  50. Accumulating evidence suggests that exercise is effective in treating many of the acute and chronic side effects of anti-cancer therapy. A recent meta-analysis supported the use of exercise to prevent or treat...

    Authors: Alexander Grabenbauer, Andrea J. Grabenbauer, Rosa Lengenfelder, Gerhard G. Grabenbauer and Luitpold V. Distel
    Citation: Radiation Oncology 2016 11:42
    Content type: Research Published on:
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Radiation Oncology

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