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  1. We report our experience of using helical tomotherapy (HT) to treat large and irregular shaped loco-regional advanced breast cancer target volumes embracing various organs at risk.

    Authors: M. N. Duma, C. Heinrich, C. Schönknecht, B. Chizzali, M. Mayinger, M. Devecka, S. Kampfer and S. E. Combs
    Citation: Radiation Oncology 2017 12:31
    Content type: Research Published on:

  2. Literature was reviewed to assess the physical aspects governing the present and emerging technologies used in intraoperative radiation therapy (IORT). Three major technologies were identified: treatment with ...

    Authors: Frank W. Hensley
    Citation: Radiation Oncology 2017 12:37
    Content type: Review Published on:

  3. A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We rep...

    Authors: David A. Palma, Timothy K. Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V. Louie, Eric Frechette, George B. Rodrigues, Brian Yaremko, Edward Yu, A. Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner…
    Citation: Radiation Oncology 2017 12:30
    Content type: Short report Published on:

  4. To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-te...

    Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt and Uwe A. Wittel
    Citation: Radiation Oncology 2017 12:29
    Content type: Research Published on:

  6. Palliative thoracic radiotherapy is an effective technique to alleviate symptoms of disease burden in advanced-stage lung cancer patients. Previous randomized controlled studies demonstrated a survival benefit...

    Authors: Patrick V. Granton, David A. Palma and Alexander V. Louie
    Citation: Radiation Oncology 2017 12:27
    Content type: Research Published on:

  7. Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-a...

    Authors: Gen Futamura, Shinji Kawabata, Naosuke Nonoguchi, Ryo Hiramatsu, Taichiro Toho, Hiroki Tanaka, Shin-Ichiro Masunaga, Yoshihide Hattori, Mitsunori Kirihata, Koji Ono, Toshihiko Kuroiwa and Shin-Ichi Miyatake
    Citation: Radiation Oncology 2017 12:26
    Content type: Research Published on:

  8. Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative an...

    Authors: David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D. Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz and Rolf Sauer
    Citation: Radiation Oncology 2017 12:25
    Content type: Review Published on:

  9. Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectivenes...

    Authors: Carsten Herskind, Lin Ma, Qi Liu, Bo Zhang, Frank Schneider, Marlon R. Veldwijk and Frederik Wenz
    Citation: Radiation Oncology 2017 12:24
    Content type: Review Published on:

  10. The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT precedin...

    Authors: Felix Sedlmayer, Roland Reitsamer, Frederik Wenz, Elena Sperk, Christoph Fussl, Julia Kaiser, Ingrid Ziegler, Franz Zehentmayr, Heinz Deutschmann, Peter Kopp and Gerd Fastner
    Citation: Radiation Oncology 2017 12:23
    Content type: Review Published on:

  12. Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in ...

    Authors: Marco Krengli, Carla Pisani, Letizia Deantonio, Daniela Surico, Alessandro Volpe, Nicola Surico and Carlo Terrone
    Citation: Radiation Oncology 2017 12:18
    Content type: Review Published on:

  14. Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy re...

    Authors: Robert Krempien and Falk Roeder
    Citation: Radiation Oncology 2017 12:8
    Content type: Review Published on:

  15. The aim of this study was to assess the dose to the humeral head planning risk volume with the currently used high tangential fields (HTF) and compare different planning techniques for breast radiotherapy incl...

    Authors: Kathrin Surmann, Jorien van der Leer, Tammy Branje, Maurice van der Sangen, Maarten van Lieshout and Coen W. Hurkmans
    Citation: Radiation Oncology 2017 12:22
    Content type: Research Published on:

  16. This study sheds light on cell inactivating processes with focus on the phenomenon of cell-in-cell (CIC). Cell-in-cell describes a cell process where one cell is being engulfed by another non-professional phag...

    Authors: Hannah Schenker, Maike Büttner-Herold, Rainer Fietkau and Luitpold V. Distel
    Citation: Radiation Oncology 2017 12:21
    Content type: Research Published on:

  17. The clinical effects of radiation dose-intensification in locally advanced non-small cell lung (NSCLCa) and other cancers are challenging to predict and are ideally studied in randomized trials. The purpose of...

    Authors: John P. Christodouleas, Matthew D. Hall, Marjorie A. van der Pas, Wensheng Guo, Timothy E. Schultheiss and Peter Gabriel
    Citation: Radiation Oncology 2017 12:19
    Content type: Research Published on:

  18. The purpose of this study was to determine the distribution of 4-borono-2-18F-fluoro-phenylalanine (18F-BPA) and L-[methyl-11C] methionine (11C-Met) in normal organs and tumors and to evaluate the usefulness of 1...

    Authors: Yoshiaki Watanabe, Hiroaki Kurihara, Jun Itami, Ryohei Sasaki, Yasuaki Arai and Kazuro Sugimura
    Citation: Radiation Oncology 2017 12:17
    Content type: Research Published on:

  19. In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could pr...

    Authors: Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Haruna Nishimaki and Shinobu Masuda
    Citation: Radiation Oncology 2017 12:16
    Content type: Research Published on:

  20. The effect of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)-guided dose-painting intensity-modulated radiation therapy (IMRT) in locoregionally advanced nasopharyngeal carci...

    Authors: Feng Liu, Xu-ping Xi, Hui Wang, Ya-qian Han, Feng Xiao, Ying Hu, Qian He, Lin Zhang, Qin Xiao, Lin Liu, Le Luo, Yun Li, Yi Mo and Hong-zhi Ma
    Citation: Radiation Oncology 2017 12:15
    Content type: Research Published on:

  21. Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...

    Authors: Matthew J. Boyer, Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu and W. Robert Lee
    Citation: Radiation Oncology 2017 12:14
    Content type: Research Published on:

  22. Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-rela...

    Authors: Gregory Vlacich, Mark J. Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr and Anthony J. Cmelak
    Citation: Radiation Oncology 2017 12:13
    Content type: Research Published on:

  23. To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC).

    Authors: Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour and Daniel M. Aebersold
    Citation: Radiation Oncology 2017 12:12
    Content type: Research Published on:

  24. Intensity-modulated proton therapy (IMPT), non-coplanar 4Ï€ intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy...

    Authors: Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen and Ke Sheng
    Citation: Radiation Oncology 2017 12:10
    Content type: Research Published on:

  25. The purpose of this study was to use 4-dimensional-computed tomography (4D-CT) to evaluate respiration-induced liver motion magnitude and influencing factors in patients with intrahepatic tumors undergoing abd...

    Authors: Yong Hu, Yong-Kang Zhou, Yi-Xing Chen and Zhao-Chong Zeng
    Citation: Radiation Oncology 2017 12:9
    Content type: Research Published on:

  26. Modern radiotherapy offers various possibilities for image guided verification of patient positioning. Different clinically relevant IGRT (image guided radiotherapy) scenarios were considered with regard to th...

    Authors: Katharina Bell, Marina Heitfeld, Norbert Licht, Christian Rübe and Yvonne Dzierma
    Citation: Radiation Oncology 2017 12:7
    Content type: Research Published on:

  27. Dose escalation of SBRT for locally advanced pancreatic cancer patients had been reported in several studies in one or three fractions, and phase I protocol was developed to investigate the maximum tolerated d...

    Authors: Shui-Wang Qing, Xiao-Ping Ju, Yang-Sen Cao and Huo-Jun Zhang
    Citation: Radiation Oncology 2017 12:6
    Content type: Study protocol Published on:

  28. To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT).

    Authors: Akram Saad, Jeffrey Goldstein, Yaacov R. Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss and Zvi Symon
    Citation: Radiation Oncology 2017 12:5
    Content type: Research Published on:

  29. Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemothe...

    Authors: Maria Vittoria Mattoli, Mariangela Massaccesi, Alessandra Castelluccia, Valentina Scolozzi, Giovanna Mantini and Maria Lucia Calcagni
    Citation: Radiation Oncology 2017 12:4
    Content type: Research Published on:

  30. To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system.

    Authors: Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa and Hiroki Shirato
    Citation: Radiation Oncology 2017 12:3
    Content type: Research Published on:

  31. To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy.

    Authors: Nina-Sophie Hegemann, Anne Schlesinger-Raab, Ute Ganswindt, Claudia Hörl, Stephanie E. Combs, Dieter Hölzel, Jürgen E. Gschwend, Christian Stief, Claus Belka and Jutta Engel
    Citation: Radiation Oncology 2017 12:2
    Content type: Research Published on:

  32. The records of 208.777 (100%) clinical trials registered at ClinicalTrials.gov were downloaded on the 19th of February 2016. Phase II and III trials including patients with glioblastoma were selected for furth...

    Authors: Nikola Cihoric, Alexandros Tsikkinis, Giuseppe Minniti, Frank J Lagerwaard, Ulrich Herrlinger, Etienne Mathier, Ivan Soldatovic, Branislav Jeremic, Pirus Ghadjar, Olgun Elicin, Kristina Lössl, Daniel M Aebersold, Claus Belka, Evelyn Herrmann and Maximilian Niyazi
    Citation: Radiation Oncology 2017 12:1
    Content type: Review Published on:

  34. Image guided radiotherapy (IGRT) is an essential pre-requisite for delivering high precision radiotherapy. We compared daily variation detected by two non-ionizing imaging modalities (surface imaging and trans...

    Authors: Marco Krengli, Gianfranco Loi, Carla Pisani, Debora Beldì, Giuseppina Apicella, Valentina Amisano and Marco Brambilla
    Citation: Radiation Oncology 2016 11:159
    Content type: Research Published on:

  35. To assess the accuracy and precision of a fully integrated pilot installation of stereoscopic X-ray imaging and kV-CBCT for automatic couch positioning in stereotactic radiotherapy of intracranial tumors. Posi...

    Authors: Barbara Zollner, Christian Heinz, Sabrina Pitzler, Farkhad Manapov, Steffi Kantz, Maya Christine Rottler, Maximilian Niyazi, Ute Ganswindt, Claus Belka and Hendrik Ballhausen
    Citation: Radiation Oncology 2016 11:158
    Content type: Research Published on:

  36. Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of per...

    Authors: J. Roesch, C. Panje, F. Sterzing, F. Mantel, U. Nestle, N. Andratschke and M. Guckenberger
    Citation: Radiation Oncology 2016 11:157
    Content type: Research Published on:

  37. Clinical target volumes (CTV) for radiotherapy (RT) in esophageal cancer (EC) are based on standard expansions of primary tumor volume. Data is needed to define regions at highest risk for occult disease, base...

    Authors: Brandon Garcia, Karyn A. Goodman, Lajhem Cambridge, Mark Dunphy and Abraham J. Wu
    Citation: Radiation Oncology 2016 11:156
    Content type: Research Published on:

  38. The purpose of this study is to find the optimal planning settings for prostate SABR-VMAT for high-risk prostate cancer patients irradiated to prostate only (PO) or prostate and pelvic lymph nodes (PPLN).

    Authors: Sarah O. S. Osman, Prakash Jeevanandam, Nithya Kanakavelu, Denise M. Irvine, Ciara A. Lyons, Suneil Jain, Alan R. Hounsell and Conor K. McGarry
    Citation: Radiation Oncology 2016 11:155
    Content type: Research Published on:

  39. To report our initial clinical experience with the novel surface imaging system Catalystâ„¢ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator for daily patient positioning in patients un...

    Authors: F. Walter, P. Freislederer, C. Belka, C. Heinz, M. Söhn and F. Roeder
    Citation: Radiation Oncology 2016 11:154
    Content type: Research Published on:

  40. In our previous study, monogalactosyl diacylglycerol (MGDG) purified from spinach was found to have cytotoxic effects in human cancer cell lines. This study further assessed whether MGDG can enhance the cytoto...

    Authors: Hiroaki Akasaka, Yoshiyuki Mizushina, Kenji Yoshida, Yasuo Ejima, Naritoshi Mukumoto, Tianyuan Wang, Sachiko Inubushi, Masao Nakayama, Yuki Wakahara and Ryohei Sasaki
    Citation: Radiation Oncology 2016 11:153
    Content type: Research Published on:

  41. Large tumor motion often leads to larger treatment volumes, especially the lung tumor located in lower lobe and adhered to chest wall or diaphragm. The purpose of this work is to investigate the impacts of pla...

    Authors: Yi Li, Jing-lu Ma, Xin Chen, Feng-wen Tang and Xiao-zhi Zhang
    Citation: Radiation Oncology 2016 11:152
    Content type: Research Published on:

  42. Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of thi...

    Authors: Michael F. Gensheimer, Matthew Nyflot, George E. Laramore, Jay J. Liao and Upendra Parvathaneni
    Citation: Radiation Oncology 2016 11:151
    Content type: Research Published on:

  43. In carbon ion radiotherapy (CIR) for esophageal cancer, organ and target motion is a major challenge for treatment planning due to potential range deviations. This study intends to analyze the impact of intraf...

    Authors: M. F. Haefner, F. Sterzing, D. Krug, S. A. Koerber, O. Jaekel, J. Debus and M. M. Haertig
    Citation: Radiation Oncology 2016 11:150
    Content type: Research Published on:

  44. To investigate second cancer risk (SCR) comparing volumetric modulated arc therapy (VMAT) and 3D conformal radiotherapy (3DCRT) with different high dose fractionation schemes.

    Authors: Daniel R. Zwahlen, Laura I. Bischoff, Günther Gruber, Marcin Sumila and Uwe Schneider
    Citation: Radiation Oncology 2016 11:149
    Content type: Research Published on:

  45. Radiomics or computer – extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomic...

    Authors: Rakesh Shiradkar, Tarun K Podder, Ahmad Algohary, Satish Viswanath, Rodney J. Ellis and Anant Madabhushi
    Citation: Radiation Oncology 2016 11:148
    Content type: Research Published on:

  46. Evaluation of set up error detection by a transperineal ultrasound in comparison with a cone beam CT (CBCT) based system in external beam radiation therapy (EBRT) of prostate cancer.

    Authors: Anne Richter, Bülent Polat, Ingulf Lawrenz, Stefan Weick, Otto Sauer, Michael Flentje and Frederick Mantel
    Citation: Radiation Oncology 2016 11:147
    Content type: Research Published on:

  47. In volumetric modulated arc therapy (VMAT), gantry angles, dose rate and the MLC positions vary with the radiation delivery. The quality assurance (QA) system should be able to catch the planning and machine e...

    Authors: Bin Liang, Bo Liu, Fugen Zhou, Fang-fang Yin and Qiuwen Wu
    Citation: Radiation Oncology 2016 11:146
    Content type: Research Published on:

  48. To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era...

    Authors: Céline Mirjolet, Paul M. Walker, Mélanie Gauthier, Cécile Dalban, Suzanne Naudy, Frédéric Mazoyer, Etienne Martin, Philippe Maingon and Gilles Créhange
    Citation: Radiation Oncology 2016 11:145
    Content type: Research Published on:

  49. Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohor...

    Authors: Calyn R. Moulton, Michael J. House, Victoria Lye, Colin I. Tang, Michele Krawiec, David J. Joseph, James W. Denham and Martin A. Ebert
    Citation: Radiation Oncology 2016 11:144
    Content type: Research Published on:

  50. The aim of this study was to analyze differences in couch shifts (setup errors) resulting from image registration of different CT datasets with free breathing cone beam CTs (FB-CBCT). As well automatic as manu...

    Authors: Markus Oechsner, Barbara Chizzali, Michal Devecka, Stephanie Elisabeth Combs, Jan Jakob Wilkens and Marciana Nona Duma
    Citation: Radiation Oncology 2016 11:142
    Content type: Research Published on:
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Radiation Oncology

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