Using meta-analysis and CNN-NLP to review and classify the medical literature for normal tissue complication probability in head and neck cancer

Table 4 Prediction model Risk of Bias in included studies

Author, Year	Risk of Bias				Applicability			Overall
Author, Year	1. Participants	2. Predictors	3. Outcome	4. Analysis	1. Participants	2. Predictors	3. Outcome	Risk of Bias	Applicability
Hubert S. Gabrys et al. [16]	+	+	+	−	+	+	+	−	+
Tsair-Fwu Lee et al., [17]	+	+	+	+	+	+	+	+	+
Tsair-Fwu Lee et al., [18]	+	+	+	+	+	+	+	+	+
Lisanne V. van Dijk et al., [19]	+	+	+	−	+	+	+	−	+
Stefano Ursino et al., [20]	+	+	+	−	+	+	+	−	+
Jamie A. Dean et al., [21]	+	+	?	?	+	+	?	?	?
Jamie A. Dean et al., [22]	+	+	−	−	+	+	−	−	−
Ivo Beetz eta al., [23]	+	+	?	+	+	+	?	?	?
Ivo Beetz eta al., [24]	+	+	−	+	+	+	−	−	−
Khadija Sheikh et al., [27]	+	+	+	+	+	+	+	+	+
Ben jamin S. Rosen et al., 2018	+	+	+	+	+	+	+	+	+
Kuo Men et al., [25]	+	+	+	−	+	+	+	−	+

^*High risk is denoted by "-"; *Low risk is denoted by " + "; *Unclear or ambiguous is denoted by "?"

ISSN: 1748-717X