Table 1 Overview about grading scales for radiation-induced pneumonitis
Grading scale | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|---|
CTCAE v5.0 | Asymptomatic; clinical or diagnostic observations only; intervention not indicated | Symptomatic; medical intervention indicated; limiting instrumental ADL | Severe symptoms; limiting self care ADL; oxygen indicated | Life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) | Death |
RTOG | Asymptomatic or mild symptoms (dry cough); slight radiographic appearances | Moderate symptomatic pneumonitis (severe cough); low grade fever; patchy radiographic appearances | Severe symptomatic pneumonitis; dense radiographic changes | Severe respiratory insufficiency/ Continuous O2/ Assisted ventilation | Death |
LENT-SOMA (EORTC) | Asymptomatic or mild symptoms; slight imaging changes | Moderate symptoms; moderate imaging changes | Severe symptoms; increased density imaging changes | Severe symptoms requiring continuous O2 or assisted ventilation | Death |