Skip to content

Advertisement

  • Letter to the Editor
  • Open Access

In regard to “Tran A, Zhang J, Woods K, Yu V, Nguyen D, Gustafson G, Rosen L, Sheng K. Treatment planning comparison of IMPT, VMAT and 4π radiotherapy for prostate cases. Radiation oncology. 2017 Jan 11; 12(1):10”

Radiation Oncology201813:63

https://doi.org/10.1186/s13014-018-1009-y

Received: 6 December 2017

Accepted: 22 March 2018

Published: 12 April 2018

The original article was published in Radiation Oncology 2017 12:10

The Letter to the Editor to this article has been published in Radiation Oncology 2018 13:66

Abstract

This article describe the three dimensional geometrical incompetency of the term “4π radiotherapy”; frequently used in radiation oncology to establish the superiority (or rather complexity) of particular kind of external beam delivery technique. It was claimed by several researchers, to obtain 4πc solid angle at target centre created by the tele-therapy delivery machine in three dimensional Euclidian space. However with the present design of linear accelerator (or any other tele-therapy machine) it is not possible to achieve more than 2πc with the allowed boundary condition of 0 ≤ Gnatry position≤πc and \( -\frac{\pi^c}{2} \)≤Couch Position≤\( +\frac{\pi^c}{2} \) .

This article describes why it is not possible to achieve a 4πc solid angle at any point in three dimensional Euclidian spaces. This article also recommends not to use the terminology “4π radiotherapy” for describing any external beam technique or its complexity as this term is geometrically wrong.

Keywords

4π radiotherapyπSold angleSolid geometry3D Euclidian spaceGantry CouchLinear acceleratorRadian

Text

I would like to make a comment on the “4π radiotherapy”; mentioned by Tarn et al. regarding the 4π radiotherapy for prostate cases. The concept of 4π radiotherapy was originally floated by Dong et al. in 2013; and subsequently used by several authors; calming to have delivered a radiotherapy technique which look into a tumour from 4π solid angle [18].

The geometrical constriction of a teletherapy machine/linear accelerator mechanically represent a Cantilever, where head anchored at only one end with a vertical support from which it is protruding. A teletherapy machine having two additional degree of freedoms; a full arc gantry rotation of (0-2πc) and a half arc couch rotation (0-πc).

Geometry of three dimensional Euclidian space, solid geometry, defines the angle obtained by a surface in terms of solid angle presented as following.
$$ \mathrm{d}\Omega =\frac{ds}{r^2} $$
where ds is the surface area and r is the radius vector can obtained a solid angle of 4πc at its centre as described below.
Solid angle at the centre of a sphere
$$ \Omega =\frac{\mathrm{Area}}{r^2}=\frac{1}{r^2}\left[{\int}_{\theta =0}^{\pi }{\int}_{\upvarphi =0}^{2\pi}\left( rSin\theta d\varphi \right).\left( rd\theta \right)\right] $$
where, r, θ and φ are radius vector polar and azimuthal angle.
$$ =\frac{4{\pi r}^2}{r^2}=4{\uppi}^{\mathrm{c}}\ \left[={12.56}^{\mathrm{c}};{}^{\mathrm{c}}\ \mathrm{is}\ \mathrm{steradian}\right]. $$
Under the geometrical boundary condition of the linear accelerator rotational degree of freedom (gantry: 00–3600-00 and couch 900–00-2700; however 900–1800–2700 is inaccessible to couch) azimuthal angle integration reduces to 0-πc. Therefore maximum accessible solid angle for a linear accelerator machine is
$$ =\frac{1}{r^2}{\int}_{\theta =0}^{\pi }{\int}_{\upvarphi =0}^{\pi}\left( rSin\theta d\varphi \right).\left( rd\theta \right)=2{\uppi}^{\mathrm{c}};\mathrm{solid}\ \mathrm{angle}\ \mathrm{obtained}\ \mathrm{by}\ \mathrm{a}\ \mathrm{hemisphere}. $$

This type of hemispherical therapy delivery is only possible for two ends of the human that is either brain or foot. Rest of the length (head neck-thorax-abdomen-pelvis) of the human body is not accessible even for a 2πc radiotherapy. Therefore claimed to have “4π radiotherapy” for prostate does not hold geometrically.

I would like to mention that, as an example, the solid angle created by a full arc (0-2πc) gantry rotation with a 40 × 40 cm2 field opening and couch angle at zero degree is
$$ \Omega\ \mathrm{Full}\ \mathrm{ARC}=\frac{Area}{r^2}=\frac{1}{100\ {cm}^2}\ \left[2\uppi\ 100\ \mathrm{cm}\times 40\ \mathrm{cm}\right]={2.51}^{\mathrm{c}}, $$
which is (1/5)th of the 4πc. Solid angle further reduces with the multileaf collimator shaped or blocked fields.

To perform a “4π radiotherapy” a patient need to be point and radiotherapy machines should be able to move to any point on the surface of a spare; under the present design of any teletherapy machines like linear accelerator, tele-cobalt, tomotherapy (Accuray Inc., Madison, WI) or Cyber knife (Accuray Inc., Madison, WI) cannot perform a “4π radiotherapy”. Probably only Brachytherapy can be near to a “4π radiotherapy” approximating (highly) the source as a point source.

A generalised geometrical misconception of “4π radiotherapy” was floated in 2013 by Dong et al. and propagating up to date (Victoria et al.) [18].

The technique described by the listed authors in this article could have been identified (or nomenclated) by something else but definitely not by “4π radiotherapy”. “4π Radiotherapy” is a geometrically non-viable and scientifically wrong concept; tagged with a fancy name to establish its superiority over generalized non-coplanar technique. Therefore the misconception about “4π radiotherapy” need to be corrected should not be used in future.

Notes

Abbreviations

c

Steradian or radian unit of solid angle

r, θ and φ: 

Radius vector polar and azimuthal angle in spherical polar coordinate

π: 

Pi is a number - approximately 3.142

Ω: 

Solid angle: defined as ratio between area and squire of the radius vector

Declarations

Acknowledgements

None

Funding

Not applicable

Availability of data and materials

No data generated, only mathematical formulation. Mathematical information used here is available in any standard mathematics text book.

Authors’ contributions

The author read and approved the final manuscript.

Ethics approval and consent to participate

Not required, no patient data/ information Involved.

Consent for publication

Not required, no patient data/ information Involved.

Competing interests

The author declares that he/she has no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of radiation Oncology, Fortis Memorial Research Institute, Gurgaon, India

References

  1. Tran A, Zhang J, Woods K, Yu V, Nguyen D, Gustafson G, Rosen L, Sheng K. Treatment planning comparison of IMPT, VMAT and 4π radiotherapy for prostate cases. Radiat Oncol. 2017;12(1):10.View ArticlePubMedPubMed CentralGoogle Scholar
  2. Dong P, Lee P, Ruan D, Long T, Romeijn E, Yang Y, Low D, Kupelian P, Sheng K. 4π non-coplanar liver SBRT: a novel delivery technique. international journal of radiation oncology* biology*. Physics. 2013;85(5):1360–6.Google Scholar
  3. Dong P, Lee P, Ruan D, Long T, Romeijn E, Low DA, Kupelian P, Abraham J, Yang Y, Sheng K. 4π noncoplanar stereotactic body radiation therapy for centrally located or larger lung tumors. International journal of radiation oncology* biology*. Physics. 2013;86(3):407–13.Google Scholar
  4. Rwigema JC, Nguyen D, Heron DE, Chen AM, Lee P, Wang PC, Vargo JA, Low DA, Huq MS, Tenn S, Steinberg ML. 4π noncoplanar stereotactic body radiation therapy for head-and-neck cancer: potential to improve tumor control and late toxicity. International journal of radiation oncology* biology*. Physics. 2015;91(2):401–9.Google Scholar
  5. Yu VY, Tran A, Nguyen D, Cao M, Ruan D, Low DA, Sheng K. The development and verification of a highly accurate collision prediction model for automated noncoplanar plan delivery. Med Phys. 2015;42(11):6457–67.View ArticlePubMedPubMed CentralGoogle Scholar
  6. Nguyen D, Rwigema JC, Victoria YY, Kaprealian T, Kupelian P, Selch M, Lee P, Low DA, Sheng K. Feasibility of extreme dose escalation for glioblastoma multiforme using 4π radiotherapy. Radiat Oncol. 2014;9(1):239.View ArticlePubMedPubMed CentralGoogle Scholar
  7. Nguyen D, Dong P, Long T, Ruan D, Low DA, Romeijn E, Sheng K. Integral dose investigation of non-coplanar treatment beam geometries in radiotherapy. Medical physics. 2014;41(1).Google Scholar
  8. Victoria YY, Landers A, Woods K, Nguyen D, Cao M, Du D, Chin RK, Sheng K, Kaprealian TB. A Prospective 4π Radiotherapy Clinical Study in Recurrent High Grade Glioma Patients. Int J Radiat Oncol Biol Phys. 2018.Google Scholar

Copyright

© The Author(s). 2018

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Please note that comments may be removed without notice if they are flagged by another user or do not comply with our community guidelines.

Advertisement