Carbon ion therapy for ameloblastic carcinoma
© Jensen et al; licensee BioMed Central Ltd. 2011
Received: 22 October 2010
Accepted: 6 February 2011
Published: 6 February 2011
Ameloblastic carcinomas are rare odontogenic tumors. Treatment usually consists of surgical resection and sometimes adjuvant radiation. We report the case of a 71 year-old male patient undergoing carbon ion therapy for extensive local relapse of ameloblastic carcinoma. Treatment outcome was favourable with a complete remission at 6 weeks post completion of radiotherapy while RT-treatment itself was tolerated well with only mild side effects. High dose radiation hence is a potential alternative for patients unfit or unwilling to undergo extensive surgery or in cases when only a subtotal resection is planned or the resection is mutilating.
Ameloblastic carcinomas are very rare odontogenic tumors sometimes referred to as malignant ameloblastoma . To date, 31 cases have been reported worldwide, with the largest series describing 14 cases 
Definitions and classifications of ameloblastic carcinomas have changed over the years, there have been various classifications, the latest by Slootweg and Müller  emphasizing histogenesis of the tumor leading to the new WHO classification in 2005 . Slootweg and Müller defined ameloblastic carcinoma as a tumor combining morphologic features of both ameloblastoma and carcinoma, which can arise de novo, ex ameloblastoma, or ex odontogenic cyst .
Most of the reported cases were discovered in the mandible, only one fifth occur in the maxilla [5, 6]. Though they claimed to exhibit a tendency towards aggressive local growth and local relapse , distant metastases are uncommon. Being a rare disease, there are no treatment guidelines. However, standard treatment has been complete surgical resection in reported cases [5, 7].
Report of a case
Interdisciplinary discussion recommended high-dose carbon ion therapy for this patient, hence he received a dose of 60 GyE carbon ions.
Immobilization consisted of an individual thermoplastic head mask with thermoplastic shoulder fixation. Planning examinations consisted of a planning CT scan (3 mm slice thickness) with the patient positioned in the individual fixation device and contrast-enhanced MRI for 3 D image correlation.
Target volumes/dose prescription
CTV1 included the macroscopic tumor. PTV1 consisted of a 3 mm margin around the CTV1 but did not extend into critical organs at risk (i.e. brain stem, spinal cord). CTV2 included CTV1 and all involved paranasal sinuses. As there were no suspect lymph nodes, elective nodal irradiation was not performed given the rarity of nodal metastases.
Daily image guidance consisted of orthogonal x-ray controls in treatment position with the x-ray tube/receptor mounted on a robot to allow imaging in almost any treatment table position. After acquisition of orthogonal x-rays, an automatic 2D-3 D pre-match was carried out (Siemens syngo PT treatment) and verified by the radiotherapist/radiation oncologist with regard to bony anatomy. Manual adjustment of the match was carried out on-line and the resulting correction vector, including rotations, subsequently applied to the patient position. Patient position was controlled in each session and shifts were always corrected using a robotic table allowing position correction in six degrees of freedom.
Treatment was carried out in 5 fractions per week hence over approximately 4 weeks.
The first follow-up examination including clinical examination and diagnostic, contrast-enhanced MRI was carried out 6 weeks post completion of radiation treatment, the second follow-up 3 months thereafter. Further follow-up radiooncological follow-up appointments are scheduled in 6-monthly intervals. The patient was also encouraged to undergo regular check-ups including full ENT clinical examinations in regular intervals (usually every 6 weeks).
With the disease being extremely rare, clinicians have to rely on various reported cases for guidance. Hence, the establishment of treatment standards is not possible. Radiotherapy has been controversially discussed in the past. Most reported cases underwent surgical removal.
Reports of ameloblastic carcinomas receiving radiation therapy are scarce and mostly from the pre-3 D and cobalt era [9–11]. To our knowledge, radiotherapy has only been given as adjuvant therapy in only a few cases [11–15] within the past 20 years. Radiation doses between 41,4 Gy and 54 Gy have been comparatively conservative [12, 13, 16] or not been reported [2, 14, 17] leading to local relapse in half of the cases. Higher radiation doses between 66 and 72 Gy in close margin/positive-margin resections as reported by Philip et al  lead to local control for the duration of available follow-up (0.8 - 3.3 years) in the reported 3 cases.
While it has been discussed in cases with incomplete resections or nodal metastases, there is no evidence for radiotherapy as a potentially definitive treatment modality yet. Faced with the opinion that aggressive treatment (recommending surgical wide excision with 2-3 cm margins ) is warranted to counterbalance high tendency of local relapse, RT was given in a high-precision technique as carbon ion therapy. Carbon ion therapy in active beam application with raster-scanned particle beams is able to produce extremely steep gradients hence delivering high doses to the tumor while sparing normal surrounding tissues. In contrast to intensity-modulated radiation therapy, integral dose to the irradiated volume is substantially lower. Also, increased biological effectiveness of carbon ion beams has been shown to be beneficial in other radioresistant tumors [18–20].
While it is beyond the scope of this case report to establish a clinical standard, our case shows that fast complete remissions of extensive ameloblastic carcinomas are possible using carbon ion therapy at substantial doses. Moreover, this treatment is accompanied by very mild treatment-related side effects (erythema, xerostomia CTC°I and mucositis CTC °I-II) and no major radiation-related toxicity; hence the patient could be spared extensive, mutilating and potentially incomplete surgical procedures.
To our knowledge, this is the first case of ameloblastic carcinoma being treated with carbon ion therapy and resulted so far in an excellent posttherapeutic outcome. Therefore radiotherapy with carbon ions should be considered in the definitive treatment of these rare tumors.
Conflicts of interest
The authors declare that they have no competing interests.
- Avon SL, McComb J, Clokie C: Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 2003, 69: 573-576.PubMedGoogle Scholar
- Hall JM, Weathers DR, Unni KK: Ameloblastic carcinoma: an analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007, 103: 799-807. 10.1016/j.tripleo.2006.11.048View ArticlePubMedGoogle Scholar
- Slootweg PJ, Müller H: Malignant ameloblstoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol 1984, 57: 168-176. 10.1016/0030-4220(84)90207-XView ArticlePubMedGoogle Scholar
- Barnes L, Everson JW, Reichart P, editors: Pathology and Genetics: Head and neck tumors. Lyon, World Health Organization 2005, 287-289.Google Scholar
- Kruse ALD, Zwahlen RA, Grätz KW: New classification of maxillary ameloblastic carcinoma based on an evidence-based literature reviwe over the last 60 years. Head Neck Oncol 2009, 1: 31. 10.1186/1758-3284-1-31PubMed CentralView ArticlePubMedGoogle Scholar
- Lolachi CM, Mada SK, Jacobs JR: Ameloblastic carcinoma of the maxilla. J Laryngol Otol 1995, 109: 1019-1022. 10.1017/S0022215100131925View ArticlePubMedGoogle Scholar
- Lucca M, D'Innocenzo R, Kraus JA, Gagari E, Hall J, Shastri K: Ameloblastic carcinoma of the maxilla: a report of 2 cases. J Oral Maxillofac Surg 2010, in press.Google Scholar
- Haberer T, Becher W, Schardt D, Kraft G: Magnetic scanning system for heavy ion therapy. Nucl Instr Meth Phys Res 1993, 330: 296-305. 10.1016/0168-9002(93)91335-KView ArticleGoogle Scholar
- Daramola JO, Abioye AA, Ajagbe HA, Aghadiuno PU: Maxillary malignant ameloblastoma with intraorbital extension: report of a case. J Oral Surg 1980, 38: 203-206.PubMedGoogle Scholar
- Lee L, Maxymiw WG, Wood RE: Ameloblastic carcinoma of the maxilla metastatic to the mandible. Case report. J Craniomaxillofac Surg 1990, 18: 247-250.View ArticlePubMedGoogle Scholar
- Miyamoto CT, Brady LW, Markoe A, Salinger D: Ameloblastoma of the jaw. Treatment with radiation therapy and a case report. Am J Clin Oncol 1991, 14: 225-230. 10.1097/00000421-199106000-00009View ArticlePubMedGoogle Scholar
- Infante-Cossio P, Hernandez-Guisado JM, Fernandez-Machin P, Garcia-Perla A, Guitierrez-Perez JL: Ameloblastic carcinoma of the maxilla: report of 3 cases. J Cranio Maxillofac Surg 1998, 26: 159-162. 10.1016/S1010-5182(98)80006-1View ArticleGoogle Scholar
- Zwahlen RA, Vogt P, Fischer FS, Grätz KW: Case report: myocardial metastasis of a maxillary malignant ameloblastoma. J Oral Maxillofac Surg 2003, 61: 731-734. 10.1053/joms.2003.50146View ArticlePubMedGoogle Scholar
- Goldenberg D, Sciubba J, Koch W, Tufano RP: Malignant odontogenic tumors: a 22-year experience. Laryngoscope 2004, 114: 1770-1774. 10.1097/00005537-200410000-00018View ArticlePubMedGoogle Scholar
- Philip M, Morris CG, Werning JW, Mendenhall WM: Radiotherapy in the treatment of ameloblastic carcinoma. J HK Coll Radiol 2005, 8: 157-161.Google Scholar
- Simko EJ, Brannon RB, Eibling DE: Ameloblastic carcinoma of the mandible. Head Neck 1998, 20: 654-659. 10.1002/(SICI)1097-0347(199810)20:7<654::AID-HED14>3.0.CO;2-4View ArticlePubMedGoogle Scholar
- Dhir K, Sciubba J, Tufano RP: Ameloblastic carcinoma of the maxilla. Oral Oncol 2003, 39: 736-741. 10.1016/S1368-8375(03)00036-8View ArticlePubMedGoogle Scholar
- Schulz-Ertner D, Nikoghosyan A, Hof H, Didinger B, Combs SE, Jäkel O, Karger CP, Edler L, Debus J: Carbon ion therapy of skull base chondrosarcomas. Int J Radiat Oncol Biol Phys 2007, 67: 171-177. 10.1016/j.ijrobp.2006.08.027View ArticlePubMedGoogle Scholar
- Schulz-Ertner D, Karger CP, Feuerhake A, Nikoghosyan A, Combs SE, Jäkel O, Edler L, Scholz M, Debus J: Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int J Radiat Oncol Biol Phys 2007, 68: 449-457. 10.1016/j.ijrobp.2006.12.059View ArticlePubMedGoogle Scholar
- Schulz-Ertner D, Nikoghosyan A, Didinger B, Münter M, Jäkel O, Karger CP, Debus J: Therapy strategies for locally advanced adenoid-cystic carcinomas using modern radiation therapy techniques. Cancer 2005, 104: 338-344. 10.1002/cncr.21158View ArticlePubMedGoogle Scholar
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