A case report of pseudoprogression followed by complete remission after proton-beam irradiation for a low-grade glioma in a teenager: the value of dynamic contrast-enhanced MRI
© Meyzer et al; licensee BioMed Central Ltd. 2010
Received: 15 October 2009
Accepted: 4 February 2010
Published: 4 February 2010
A fourteen years-old boy was treated post-operatively with proton therapy for a recurrent low-grade oligodendroglioma located in the tectal region. Six months after the end of irradiation (RT), a new enhancing lesion appeared within the radiation fields. To differentiate disease progression from radiation-induced changes, dynamic susceptibility contrast-enhanced (DSCE) MRI was used with a T2* sequence to study perfusion and permeability characteristics simultaneously. Typically, the lesion showed hypoperfusion and hyperpermeability compared to the controlateral normal brain. Without additional treatment but a short course of steroids, the image disappeared over a six months period allowing us to conclude for a pseudo-progression. The patient is alive in complete remission more than 2 years post-RT.
The occurrence of new contrast enhancing lesions on routine MRI follow-up after radiation therapy (RT) for brain gliomas was observed more than ten years ago but remains problematic because standard MR imaging techniques do not allow a clear distinction between recurrent tumour and radiation-induced lesions [1, 2]. Recently, "pseudo-progression" was defined as conventional MR images compatible with progression, occurring shortly after concomitant radio-chemotherapy (CRC), as a transient phenomenon with spontaneous improvement or stabilization after several months [3–5]. This was mainly described in adult and paediatric populations with high-grade gliomas whose new standard of care is CRC followed by adjuvant chemotherapy [6, 7].
We report here a clinical case showing a new contrast-enhancing lesion discovered on a systematic MRI proposed to a fourteen years-old boy treated six months before for a recurrent low-grade glioma by surgery and proton-therapy. Dynamic Susceptibility Contrast (DSC) MR imaging and planned follow-up lead to the diagnosis of pseudo-progression. This phenomenon has rarely been described in children with supra-tentorial low-grade gliomas after proton beam RT, particularly with this type of advanced MR technique.
Initial presentation and conventional MRI description
Conventional and Dynamic MRI with Permeability visualization and Perfusion estimate
Post-treatment modifications, evolution with time and micro-vascular hypothesis
Subacute radiation-induced modifications have been described previously in childhood gliomas, with or without concomitant or sequential use of chemotherapy [1, 12–14]. In adults, these changes are more and more reported after combined radio-chemotherapy [4, 5, 15]. MRI findings usually consist on new contrast enhancing mass on T1-weighted imaging with gadolinium, which is indistinguishable from tumour progression. It occurs usually within the irradiated tumour volume but radiation-induced lesions could be located less commonly in the controlateral hemisphere, remotely from the primary tumour site . To our knowledge, it is the first case of pseudo-progression fully described after exclusive proton RT. Here, time of occurrence was delayed (6 months) since the typical time frame is rather within 3 months after chemo-radiation, possibly due to the absence of concomitant chemotherapy [3, 5, 6]. Cerebral injury has been classified according to time to appearance after RT  as "acute", with brain oedema occurring during RT, mostly transient and reversible; subacute or "early delayed" injury, occurring a few weeks to three months post-RT, improving within six weeks; late injury, occurring months to years post-RT, including true radionecrosis. It is often irreversible, progressive, and possibly lethal and constitutes the major dose-limiting clinical complication of brain irradiation, particularly in children. Pseudo-progression (PsP) could be considered as a pathological continuum between acute post-RT reaction and treatment-related necrosis . Mechanisms behind these events are not fully understood but are probably related to micro-vessels changes. Post-RT brain injury induces a focal tissue reaction with inflammatory component and increased capillary permeability, causing fluid transudation into the interstitial space and brain oedema. Transient alterations in the blood-brain barrier may be responsible for new or increased contrast enhancement, falsely suggesting tumour progression, with low perfusion values .
Role of PET and advanced MR techniques in the diagnosis of "pseudo-progresion", clinical implication
This DSC-MR technique evaluates tissue changes, close to the physiopathology of PsP, whereas metabolic tools as FDG-PET or MR spectroscopy (MRS) analyse level of glucose uptake or distribution of metabolites peaks. MRS can distinguish recurrent true necrosis from active tumour [16–18] but it needs long acquisition time. In 18FDG-PET, FDG uptake is not specific of tumour tissue and false positive can be observed in non malignant inflammatory processes. The use of aminoacid tracers as 11C-methionine better discriminates post-RT necrosis from tumour recurrence  but it is rarely available in daily practice. Recently, the DSC-MR technique was proposed for adult high-grade gliomas in this situation [20, 21] as an alternative tool. It can be incorporated in the routine follow-up, within the interval of three to six months post-RT where PsP can be observed. Importantly, there is a risk of including children with gliomas in phase II studies for "recurrent disease" that would be spontaneously reversible, leading to false positive results, consequently delivering salvage treatments for "pseudo-progressive" patients who could be, at the contrary, potentially long term survivors .
The lack of typical clinical symptoms and the limits of anatomical MRI techniques imply that any subacute change suggesting disease progression may be considered as possible PsP. Post-RT therapy should not be interrupted too early  and DSC-MRI could help for distinguishing PsP from real progression.
Written informed consent was obtained from the parents and the patient for publication of this case report and accompagnying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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