Extraneural metastases from cranial meningioma: a case report
© Abboud et al; licensee BioMed Central Ltd. 2009
Received: 25 March 2009
Accepted: 06 July 2009
Published: 06 July 2009
Extracranial metastases from brain meningiomas is a rare, but well-documented entity. Metastases occur mostly in the lungs, pleura and liver, but may also affect lymph nodes and bones. We report here on a patient who was treated for an atypical brain meningioma with multiple surgeries and multiple sessions of stereotactic radiosurgery with good control of his brain disease. Thirteen years after diagnosis, he developed bilateral large sacroiliac and abdominal metastases.
Meningioma is a common intracranial tumor. Most meningiomas are benign slowly growing tumors that histologically correspond to World Health Organization (WHO) grade I. However, atypical (WHO grade II) and anaplastic (WHO grade III) meningiomas show a more aggressive biological behavior with a high risk of local recurrence and a less favorable prognosis. Extracranial dissemination of meningiomas has been rarely reported. We present here an unusual case of a patient who was treated for an atypical brain meningioma originally diagnosed in 1994 and treated by multiple surgical resections, several courses of stereotactic radiosurgery and radiotherapy, and a course of whole-brain radiotherapy with good control of his cranial disease. His disease remained confined to the brain for thirteen years, after which he developed bilateral large sacroiliac and abdominal metastases.
The patient is a 45-year-old man who was admitted for the first time in 1994 at the age of 31 for persistent headache. Work-up revealed a large left tentorial meningioma. He had no history of cranial radiation during childhood or clinical features of neurofibromatosis type I or II. He underwent gross total surgical resection. Pathologic evaluation, which was recently re-reviewed, showed an atypical meningioma with the following features: hypercellularity with sheets of monotonous meningothelial cells displaying a prominent mitotic activity with around 4 mitoses per 10 high power fields. In May of 1997, follow-up brain MRI revealed a recurrence in the vicinity of the original tumor bed. Surgery was performed with gross total tumor removal. Pathologic evaluation again showed meningioma with similar pathologic features. In September 1999, he developed multiple small tumor recurrences in the parietal, occipital and cerebellar lobes for which he underwent stereotactic radiosurgery (SRS) with excellent results on tumor control. In September 2001, the patient developed additional recurrent lesions in multiple sites in the infratentorial, retroclival, left optic nerve sheet, and foramen magnum regions.
Meningioma is a common intracranial tumor that accounts for 14 to 19% of all primary intracranial neoplasms . It is generally a benign tumor, but recurrence is not uncommon notably for atypical and anaplastic variants. A report by the World Health Organization indicated that 94.3% of meningiomas are benign with a 5-year recurrence rate of 3% compared to 38% and 78% for atypical and anaplastic meningiomas, respectively . Distant metastases from benign meningiomas are extremely rare and almost all of the reported cases were associated with a large intracranial tumor . On the other hand, the rate of distant metastases could reach 5% for atypical and 30% for anaplastic or malignant meningiomas .
Several histologic parameters have been identified as indicators of aggressive behavior and predictors of rapid recurrence of meningiomas. These include high cellularity, mitotic rate, nuclear pleomorphism, presence of foci of necrosis, and invasion of adjacent structures [5–9]. Other reported prognostic indicators of tumor recurrence include change in histologic morphology, malignant transformation, cellular heterogeneity, and multicentricity [10, 11]. In the case presented here, atypical histologic features such as hypercellularity, relatively increased mitotic rate (4 mitoses per 10 high power fields), high proliferation index, and multicentricity were present.
According to one report, tumors that did metastasize usually had histologic features consistent with a malignant phenotype, such as focal necrosis, brain invasion, cellular pleomorphism, and frequent mitoses . Meningiomas may disseminate through hematogenous, lymphatic, or cerebrospinal fluid routes . The most common pathway of metastasis in meningiomas is considered to be through the cerebrospinal fluid but this does not explain extraneural metastases [14–16]. The other mode of metastatic spread occurs through the passage of tumor cells into venous channels and spread through the right blood circulation into the lungs, pleura, and other organs [17, 18]. Isolated hepatic or renal metastasis may occur through the vertebral (meningorachidian) venous system. These vertebral veins have several connections with the veins of the skull, spinal canal, vertebral column, and the intercostal veins of the thoracoabdominal wall.
The role of chemotherapy is limited in meningioma; there are no or limited proven benefit from any systemic therapy and no clear drug or combination regimen that has given consistent responses.
In order of descending frequency, metastases from meningiomas occur in the lungs and pleura, liver, lymph nodes, and bone . Our patient had metastatic lesions in both sacroiliac regions and in both kidneys with remarkable symmetry in these locations. Sacral metastases from benign intracranial meningiomas are rare occurrences and could only be found in two reports [21, 22]. However, renal metastases from meningiomas have been reported more often and constituted in one report 8% of all metastases from intracranial benign and malignant meningiomas . We could not find any report with description of symmetrical features in meningioma metastases.
In conclusion, we report here the case of a 45-year-old man who developed bilateral sacroiliac and renal metastases from a recurrent intracranial meningioma of atypical histology 13 years after initial diagnosis.
Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Wara WM, Sheline GE, Newman H, Townsend JJ, Boldrey EB: Radiation therapy of meningiomas. AJR 1975, 123: 453-8.View ArticleGoogle Scholar
- Jaaskelainen J, Haltia M, Servo A: Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy and outcome. Surg Neurol 1986, 25: 233-42. 10.1016/0090-3019(86)90233-8View ArticlePubMedGoogle Scholar
- Uchibori M, Odake G, Ueda S, Yasuda N, Hisa I: Parapharyngeal meningioma extending from the intracranial space. Neuroradiology 1990,32(1):53-55. 10.1007/BF00593943View ArticlePubMedGoogle Scholar
- Enam SA, Abdulrauf S, Mehta B, Malik GM, Mahmood A: Metastasis in meningioma. Acta Neurochir (Wien) 1996, 138: 1172-7. 10.1007/BF01809747View ArticleGoogle Scholar
- Simpson D: Recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 1957, 20: 22-39. 10.1136/jnnp.20.1.22PubMed CentralView ArticlePubMedGoogle Scholar
- Skullerud K, Loken AC: The prognosis in meningiomas. Acta Neuropathol (Berl) 1974, 29: 337-44. 10.1007/BF00685486View ArticleGoogle Scholar
- Jellinger K, Slowik F: Histological subtypes and prognostic problems in meningiomas. J Neurol 1975, 208: 279-98. 10.1007/BF00312803View ArticlePubMedGoogle Scholar
- Deen HGJ, Scheithauer BW, Ebersold MJ: Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 1982,56(3):317-322. 10.3171/jns.1982.56.3.0317View ArticlePubMedGoogle Scholar
- de la Monte SM, Flickinger J, Linggood RM: Histopathologic features predicting recurrence of meningiomas following subtotal resection. Am Surg Pathol 1986,10(12):836-43. 10.1097/00000478-198612000-00002View ArticleGoogle Scholar
- Inoue H, Tamura M, Koizumi H, Nakamura M, Naganuma H, Ohye C: Clinical pathology of malignant meningiomas. Acta Neurochir 1984, 73: 179-91. 10.1007/BF01400851View ArticlePubMedGoogle Scholar
- Borovich B, Doron Y: Recurrence of intracranial meningiomas: the role played by regional multicentricity. J Neurosurg 1986, 64: 58-63. 10.3171/jns.1986.64.1.0058View ArticlePubMedGoogle Scholar
- New PFJ, Hesselink JR, O'Carroll CP, Kleinman GM: Malignant meningiomas: CT and histological criteria, including a new CT sign. Am J Neuroradiol 1982, 3: 267-76.PubMedGoogle Scholar
- Wu JK, Kasdon DL, Whitmore EL: Metastatic meningioma to cervical vertebra: A case report. Neurosurgery 1985, 17: 75-9. 10.1097/00006123-198507000-00013View ArticlePubMedGoogle Scholar
- Akimura T, Orita T, Hayashida O, Nishizaki T, Fudaba H: Malignant meningioma metastasizing through the cerebrospinal pathway. Acta Neurol Scand 1992, 85: 368-71.View ArticlePubMedGoogle Scholar
- Cramer P, Thomale UW, Okuducu AF, Lemke AJ, Stockhammer F, Woiciechowsky C: An atypical spinal meningioma with CSF metastasis: Fatal progression despite aggressive treatment. Case report. J Neurosurg Spine 2005, 3: 153-8. 10.3171/spi.2005.3.2.0153View ArticlePubMedGoogle Scholar
- Ludwin SK, Conley FK: Malignant meningioma metastasizing through the cerebrospinal pathways. J Neurol Neurosurg Psychiatry 1975, 38: 136-42. 10.1136/jnnp.38.2.136PubMed CentralView ArticlePubMedGoogle Scholar
- Shuangshoti S, Hongsaprabhas C, Netsky MG: Metastasizing meningioma. Cancer 1970, 26: 832-41. PublisherFullText 10.1002/1097-0142(197010)26:4<832::AID-CNCR2820260416>3.0.CO;2-SView ArticlePubMedGoogle Scholar
- Figuera BE, Quint DJ, McKeever PE, Chandler WF: Extracranial metastatic meningioma. British Journal of radiology 1999, 72: 513-516.View ArticleGoogle Scholar
- Batson V: The function of the vertebral veins and their role in the spread of metastases. Ann Surg 1940, 112: 138-149. 10.1097/00000658-194007000-00016PubMed CentralView ArticlePubMedGoogle Scholar
- Karasik JL, Mullens S: A survey of metastatic meningiomas. J Neurosurg 1974, 40: 206-12. 10.3171/jns.1974.40.2.0206View ArticleGoogle Scholar
- Conrad MD, Schonauer C, Pelissou-Guyotat I, Morel C, Madarassy G, Deruty R: Acta Neurochir (Wien). 2001, 143: 935. 10.1007/s007010170024View ArticleGoogle Scholar
- Lee YY, Wen-Wei Hsu R, Huang TJ, Hsueh S, Wang JY: Metastatic Meningioma in the Sacrum. Spine 2002, 27: E100-E103. 10.1097/00007632-200202150-00022View ArticlePubMedGoogle Scholar
- Salchmann M: Malignant meningiomas. In Meningiomas. Edited by: Al-Mefti O. New York: Raven Press; 1991:75-85.Google Scholar
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