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  1. Research

    Application of the new 8th TNM staging system for non-small cell lung cancer: treated with curative concurrent chemoradiotherapy

    The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were...

    Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Jin Ho Song and Ki Mun Kang

    Radiation Oncology 2017 12:122

    Published on: 21 July 2017

  2. Research

    Biomarkers of resistance to radiation therapy: a prospective study in cervical carcinoma

    Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomar...

    P. Moreno-Acosta, A. Vallard, S. Carrillo, O. Gamboa, A. Romero-Rojas, M. Molano, J. Acosta, D. Mayorga, C. Rancoule, M.A. Garcia, M. Cotes Mestre and N. Magné

    Radiation Oncology 2017 12:120

    Published on: 17 July 2017

  3. Research

    Clinical workflow for MR-only simulation and planning in prostate

    To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients.

    Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos and Margie Hunt

    Radiation Oncology 2017 12:119

    Published on: 17 July 2017

  4. Research

    Analyses of distribution and dosimetry of brain metastases in small cell lung cancer with relation to the neural stem cell regions: feasibility of sparing the hippocampus in prophylactic cranial irradiation

    This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).

    Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing LV, Jun Liu, Xu-Wei Cai and Xiao-Long Fu

    Radiation Oncology 2017 12:118

    Published on: 15 July 2017

  5. Research

    Investigation of irradiated volume in linac-based brain hypo-fractionated stereotactic radiotherapy

    Emerging techniques such as brain hypo-fractionated radiotherapy (HF-RT) involve complex cases with limited guidelines for plan quality and normal tissue tolerances. The purpose of the present study was to sta...

    Mark Ruschin, Arjun Sahgal, Hany Soliman, Sten Myrehaug, May Tsao, Collins Yeboah, Arman Sarfehnia, Brige Chugh, Alex Kiss and Young Lee

    Radiation Oncology 2017 12:117

    Published on: 14 July 2017

  6. Research

    Excellent local control and tolerance profile after stereotactic body radiotherapy of advanced hepatocellular carcinoma

    To evaluate the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of advanced hepatocellular carcinoma (HCC).

    Eleni Gkika, Michael Schultheiss, Dominik Bettinger, Lars Maruschke, Hannes Philipp Neeff, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu and Thomas Baptist Brunner

    Radiation Oncology 2017 12:116

    Published on: 12 July 2017

  7. Research

    Spinal bone metastases in colorectal cancer: a retrospective analysis of stability, prognostic factors and survival after palliative radiotherapy

    This retrospective analysis aimed to analyse the stability of spinal bone metastases in colorectal cancer (CRC) patients following radiotherapy (RT) by use of a validated score and to assess prognostic factors...

    Tilman Bostel, Robert Förster, Ingmar Schlampp, Tania Sprave, Thomas Bruckner, Nils Henrik Nicolay, Stefan Ezechiel Welte, Jürgen Debus and Harald Rief

    Radiation Oncology 2017 12:115

    Published on: 11 July 2017

  8. Research

    Simultaneous integrated boost therapy of carcinoma of the hypopharynx/larynx with and without flattening filter - a treatment planning and dosimetry study

    The aim of this study was to investigate if the flattening filter free (FFF) irradiation mode of a linear accelerator (linac) is advantageous as compared to the flat beam (FF) irradiation mode in intensity mod...

    Barbara Dobler, Tina Obermeier, Matthias G. Hautmann, Amine Khemissi and Oliver Koelbl

    Radiation Oncology 2017 12:114

    Published on: 5 July 2017

  9. Research

    Correlation between delivered radiation doses to the brainstem or vestibular organ and nausea & vomiting toxicity in patients with head and neck cancers – an observational clinical trial

    Today intensity modulated radiation therapy (IMRT) can be considered the standard of care in patients with head and neck tumors. IMRT treatment plans are proven to reduce acute treatment related side effects b...

    Kilian Schiller, Hanno Martin Specht, Bernhard Haller, Daniela Hallqvist, Michal Devecka, Aaron Becker von Rose, Stephanie Elisabeth Combs and Steffi Pigorsch

    Radiation Oncology 2017 12:113

    Published on: 4 July 2017

  10. Research

    Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old

    The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arte...

    Yuichiro Hayashi, Kenji Mitsudo, Kaname Sakuma, Masaki Iida, Toshinori Iwai, Hideyuki Nakashima, Yoshiyuki Okamoto, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Izumi Koike, Masaharu Hata and Iwai Tohnai

    Radiation Oncology 2017 12:112

    Published on: 3 July 2017

  11. Research

    Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak

    Cellular responses to proton beam irradiation are not yet clearly understood, especially differences in the relative biological effectiveness (RBE) of high-energy proton beams depending on the position on the ...

    Hidehiro Hojo, Takeshi Dohmae, Kenji Hotta, Ryosuke Kohno, Atsushi Motegi, Atsushi Yagishita, Hideki Makinoshima, Katsuya Tsuchihara and Tetsuo Akimoto

    Radiation Oncology 2017 12:111

    Published on: 3 July 2017

  12. Review

    Systematic review of patient reported quality of life following stereotactic ablative radiotherapy for primary and metastatic liver cancer

    Stereotactic ablative radiotherapy (SABR) is a safe and effective modality in patients with liver cancer who are ineligible for other local therapies. However SABR is not current standard of practice and requi...

    Adam Mutsaers, Jeffrey Greenspoon, Cindy Walker-Dilks and Anand Swaminath

    Radiation Oncology 2017 12:110

    Published on: 29 June 2017

  13. Research

    Idelalisib may have the potential to increase radiotherapy side effects

    Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin’s lymphoma and small lymphocytic lymphoma. It is a...

    Thomas Gryc, Florian Putz, Nicole Goerig, Sonia Ziegler, Rainer Fietkau, Luitpold V. Distel and Barbara Schuster

    Radiation Oncology 2017 12:109

    Published on: 28 June 2017

  14. Research

    Dosimetric evaluation of synthetic CT for magnetic resonance-only based radiotherapy planning of lung cancer

    Interest in MR-only treatment planning for radiation therapy is growing rapidly with the emergence of integrated MRI/linear accelerator technology. The purpose of this study was to evaluate the feasibility of ...

    Hesheng Wang, Hersh Chandarana, Kai Tobias Block, Thomas Vahle, Matthias Fenchel and Indra J. Das

    Radiation Oncology 2017 12:108

    Published on: 26 June 2017

  15. Review

    Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: a systematic review and meta-analysis

    In patients with one to three brain metastases who undergo resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the resection cavity. I...

    Nayan Lamba, Ivo S. Muskens, Aislyn C. DiRisio, Louise Meijer, Vanessa Briceno, Heba Edrees, Bilal Aslam, Sadia Minhas, Joost J. C. Verhoeff, Catharina E. Kleynen, Timothy R. Smith, Rania A. Mekary and Marike L. Broekman

    Radiation Oncology 2017 12:106

    Published on: 24 June 2017

  16. Research

    Analyzing human decisions in IGRT of head-and-neck cancer patients to teach image registration algorithms what experts know

    In IGRT of deformable head-and-neck anatomy, patient setup corrections are derived by rigid registration methods. In practice, experienced radiation therapists often correct the resulting vectors, thus indicat...

    Eva Maria Stoiber, Nina Bougatf, Hendrik Teske, Christian Bierstedt, Dieter Oetzel, Jürgen Debus, Rolf Bendl and Kristina Giske

    Radiation Oncology 2017 12:104

    Published on: 21 June 2017

  17. Research

    Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications

    To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast ir...

    Seung Hyuck Jeon, Kyung Hwan Shin, So-Yeon Park, Jung-in Kim, Jong Min Park, Jin Ho Kim, Eui Kyu Chie and Hong-Gyun Wu

    Radiation Oncology 2017 12:103

    Published on: 20 June 2017

  18. Review

    Radiation therapy for older patients with brain tumors

    The incidence of brain tumors in the elderly population has increased over the last few decades. Current treatment includes surgery, radiotherapy and chemotherapy, but the optimal management of older patients ...

    Giuseppe Minniti, Andrea Riccardo Filippi, Mattia Falchetto Osti and Umberto Ricardi

    Radiation Oncology 2017 12:101

    Published on: 19 June 2017

  19. Research

    Intensity-modulated radiation therapy from 70Gy to 80Gy in prostate cancer: six- year outcomes and predictors of late toxicity

    To report grade ≥2 overall late rectal and urinary toxicities in patients (pts) with prostate cancer treated by intensity-modulated radiotherapy (IMRT) at 3 dose-levels. Identify predictors of radiation toxici...

    Maria Jolnerovski, Julia Salleron, Véronique Beckendorf, Didier Peiffert, Anne-Sophie Baumann, Valérie Bernier, Sandrine Huger, Vincent Marchesi and Ciprian Chira

    Radiation Oncology 2017 12:99

    Published on: 16 June 2017

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