Table 4 Multivariate analysis of predictive factors for survival in locally advanced upper rectal cancer patients (n = 207)
Variables | OS HR (95% CI) | P-value | LRFS HR (95% CI) | P-value | DMFS HR (95% CI) | P-value |
|---|---|---|---|---|---|---|
Radiotherapy | ||||||
No/yes | 0.780 (0.360–1.691) | 0.529 | 0.226 (0.040–1.292) | 0.095 | 1.409 (0.745–2.664) | 0.292 |
Pretreatment CEA level | ||||||
< 5ng/ml/ ≥ 5ng/ml | 1.880 (0.982–3.598) | 0.057 | 1.377 (0.324–5.855) | 0.665 | 1.926 (1.077–3.442) | 0.027 |
Distance from the anal verge | ||||||
≤ 12cm/ > 12cm | 1.748 (0.506–6.039) | 0.377 | 7.318 (1.219–43.923) | 0.029 | 1.040 (0.310–3.485) | 0.95 |
Pathological differentiation degree | ||||||
High, moderate/low differentiation | 3.636 (1.300–10.170) | 0.014 | 13.154 (2.960–58.455) | 0.001 | 1.453 (0.479–4.403) | 0.509 |
pT stage | ||||||
Tis-T3/T4 | 1.346 (0.659–2.750) | 0.415 | 1.320 (0.359–4.849) | 0.676 | 1.132 (0.607–2.112) | 0.697 |
pN stage | ||||||
N0-N1/N2 | 2.787 (1.332–5.830) | 0.006 | 0.858 (0.194–3.801) | 0.84 | 2.705 (1.373–5.326) | 0.004 |
pTNM stage | ||||||
pCR,0-II/III | 2.421 (0.894–6.553) | 0.082 | 5.268 (0.569–48.740) | 0.143 | 2.128 (0.917–4.936) | 0.079 |
4 ~ 6 months adjuvant chemotherapy | ||||||
Yes/no | 2.298 (1.109–4.762) | 0.025 | 0.798 (0.216–2.952) | 0.735 | 2.558 (1.315–4.978) | 0.006 |