Table 1 Patient characteristic in locally advanced upper rectal cancer before matching
Variable | Overall population | Radiotherapy group (%) (n = 69) | Non-radiotherapy group (%) (n = 294) | P-value |
|---|---|---|---|---|
Age | ||||
≤ 60 years | 218 | 58 (84.1) | 160 (54.4) | < 0.001 |
> 60 years | 145 | 11 (15.9) | 134 (45.6) | |
Sex | ||||
Female | 133 | 27 (39.1) | 106 (36.1) | 0.678 |
Male | 230 | 42 (60.9) | 188 (63.9) | |
Preoperative CEA(ng/ml) | ||||
< 5 | 268 | 49 (71.0) | 219 (74.5) | 0.648 |
≥ 5 | 95 | 20 (29.0) | 75 (25.5) | |
Distance from anal verge(cm) | ||||
≤ 12 | 259 | 63 (91.3) | 196 (66.7) | < 0.001 |
> 12 | 104 | 6 (8.7) | 98 (33.3) | |
Pathological differentiation degree | ||||
High differentiation | 26 | 5 (7.2) | 21 (7.1) | 0.125 |
Moderate differentiation | 325 | 59 (85.5) | 266 (90.5) | |
Low differentiation | 12 | 5 (7.2) | 7 (2.4) | |
Circumferential margin status | ||||
Positive | 2 | 0 (0.0) | 2 (0.7) | 1.000 |
Negative | 361 | 69 (100.0) | 292 (99.3) | |
Lymphovascular invasion | ||||
Yes | 21 | 7 (10.1) | 14 (4.8) | 0.091 |
No | 342 | 62 (89.9) | 280 (95.2) | |
Perineural invasion | ||||
Yes | 16 | 5 (7.2) | 11 (3.7) | 0.200 |
No | 347 | 64 (92.8) | 283 (96.3) | |
Number of lymph nodes dissected | ||||
< 12 | 222 | 47 (68.1) | 175 (59.5) | 0.188 |
≥ 12 | 141 | 22 (31.9) | 119 (40.5) | |
pT stage | ||||
Tis | 1 | 1 (1.4) | 0 (0.0) | 0.243 |
T1 | 5 | 1 (1.4) | 4 (1.4) | |
T2 | 19 | 6 (8.7) | 13 (4.4) | |
T3 | 118 | 23 (33.3) | 95 (32.3) | |
T4a | 215 | 37 (53.6) | 178 (60.5) | |
T4b | 5 | 1 (1.4) | 4 (1.4) | |
pN stage | ||||
N0 | 158 | 24 (34.8) | 134 (45.6) | 0.075 |
N1 | 134 | 24 (34.8) | 110 (37.4) | |
N2a | 46 | 13 (18.8) | 33 (11.2) | |
N2b | 25 | 8 (11.6) | 17 (5.8) | |
pTNM stage | ||||
pCR/0 | 1 | 1 (1.4) | 0 (0.0) | 0.009 |
I | 3 | 2 (2.9) | 1 (0.3) | |
IIA | 57 | 7 (10.1) | 50 (17.0) | |
IIB | 94 | 12 (17.4) | 82 (27.9) | |
IIC | 3 | 0 (0.0) | 3 (1.0) | |
IIIA | 20 | 5 (7.2) | 15 (5.1) | |
IIIB | 116 | 21 (30.4) | 95 (32.3) | |
IIIC | 69 | 21 (30.4) | 48 (16.3) | |
4 ~ 6 months adjuvant chemotherapy | ||||
Yes | 116 | 37 (53.6) | 79 (26.9) | < 0.001 |
No | 247 | 32 (46.4) | 215 (73.1) | |