Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma

Cai, Wenwen; Ding, Shouliang; Li, Huali; Zhou, Xuanru; Dou, Wen; Zhou, Linghong; Song, Ting; Li, Yongbao

doi:10.1186/s13014-024-02401-0

Radiation Oncology

Table 2 The comparison of dosimetric metrics for thirty-eight patients in the unit of Gy (mean ± standard deviation) between clinical plans, automatic plans with warm start and cold start

From: Automatic IMRT treatment planning through fluence prediction and plan fine-tuning for nasopharyngeal carcinoma

Structures	Metrics (Gy)	Clinical plans	Automatic plans with warm start	Automatic plans with cold start	P1	P2	P3
PTV-GTV	D_2%	75.80 ± 0.56	74.54 ± 0.53	74.38 ± 0.71	< 0.001	< 0.001	0.62
	D_98%	70.30 ± 0.58	70.79 ± 0.36	69.31 ± 0.82	< 0.001	< 0.001	0.002
	CI	0.983 ± 0.02	0.996 ± 0.00	0.939 ± 0.05	< 0.001	< 0.001	< 0.001
	HI	0.064 ± 0.01	0.042 ± 0.01	0.058 ± 0.01	< 0.001	0.32	< 0.001
PTV-1	D_2%	75.43 ± 0.57	74.14 ± 0.52	74.06 ± 0.07	< 0.001	< 0.001	0.92
	D_98%	62.10 ± 1.88	61.57 ± 1.81	61.06 ± 2.32	< 0.001	< 0.001	< 0.001
	CI	0.993 ± 0.01	0.992 ± 0.01	0.963 ± 0.02	0.06	< 0.001	0.004
	HI	0.191 ± 0.03	0.187 ± 0.03	0.188 ± 0.04	0.08	0.16	0.54
PTV-2	D_2%	74.47 ± 0.70	73.38 ± 0.53	73.42 ± 0.68	< 0.001	0.002	0.56
	D_98%	55.52 ± 1.76	55.54 ± 1.67	55.58 ± 1.91	0.54	0.06	0.31
	CI	0.986 ± 0.01	0.991 ± 0.00	0.979 ± 0.01	0.001	0.002	< 0.001
	HI	0.304 ± 0.03	0.295 ± 0.03	0.292 ± 0.03	< 0.001	0.16	0.01
PTV-LN(L)	D_2%	70.31 ± 2.87	70.15 ± 2.83	70.72 ± 2.76	0.32	0.03	0.03
	D_98%	67.10 ± 2.42	67.13 ± 2.46	68.10 ± 2.09	0.56	0.004	0.006
	CI	0.994 ± 0.01	0.998 ± 0.00	0.999 ± 0.00	< 0.001	< 0.001	0.16
	HI	0.039 ± 0.01	0.036 ± 0.01	0.033 ± 0.01	0.04	0.06	0.08
PTV-LN(R)	D_2%	69.72 ± 3.06	69.56 ± 2.73	70.32 ± 2.78	0.59	< 0.001	< 0.001
	D_98%	66.58 ± 2.81	66.71 ± 2.70	67.92 ± 2.84	0.03	< 0.001	0.007
	CI	0.992 ± 0.01	0.998 ± 0.00	0.999 ± 0.00	< 0.001	< 0.001	0.69
	HI	0.038 ± 0.01	0.035 ± 0.01	0.030 ± 0.01	0.20	0.006	0.08
Brainstem	D_max	58.51 ± 5.89	50.17 ± 6.43	51.29 ± 6.25	< 0.001	< 0.001	< 0.001
Spinal cord	D_max	36.28 ± 1.46	35.21 ± 2.33	35.15 ± 2.71	0.002	0.08	0.43
Chiasm	D_max	47.01 ± 19.41	45.42 ± 22.04	46.60 ± 21.11	0.26	0.71	0.47
Left optic nerve	D_max	39.99 ± 22.17	39.69 ± 23.64	40.57 ± 22.44	0.68	0.28	0.09
Right optic nerve	D_max	40.36 ± 21.96	38.83 ± 23.20	39.79 ± 22.07	0.07	0.77	0.12
Left len	D_max	6.83 ± 3.04	8.53 ± 5.26	10.24 ± 5.5.82	0.001	< 0.001	0.01
Right len	D_max	7.12 ± 3.54	9.32 ± 6.32	11.15 ± 7.17	< 0.001	< 0.001	0.01
Left parotid gland	D_mean	38.24 ± 3.87	35.73 ± 5.03	36.16 ± 5.20	< 0.001	0.01	0.002
Left parotid gland	D_median	33.03 ± 5.87	30.51 ± 7.91	30.54 ± 7.43	0.002	< 0.001	0.61
Right parotid gland	D_mean	38.38 ± 3.11	35.83 ± 4.00	37.49 ± 4.51	< 0.001	0.06	< 0.001
Right parotid gland	D_median	32.81 ± 4.26	29.85 ± 5.84	31.04 ± 6.49	< 0.001	0.13	< 0.001
Left temporal lobe	D_mean	18.80 ± 6.96	19.00 ± 7.47	19.34 ± 8.0	0.98	0.02	0.004
Left temporal lobe	D_median	15.08 ± 7.73	15.32 ± 8.21	16.01 ± 9.04	0.67	0.004	0.006
Right temporal lobe	D_mean	19.23 ± 7.49	18.80 ± 7.38	19.84 ± 7.64	0.01	0.19	< 0.001
Right temporal lobe	D_median	15.85 ± 8.77	15.19 ± 8.02	16.26 ± 8.97	0.04	0.43	0.004
Left mandible	D_mean	42.74 ± 6.00	42.18 ± 5.85	43.27 ± 5.35	0.004	0.23	< 0.001
Left mandible	D_median	43.24 ± 6.44	42.50 ± 6.54	43.93 ± 6.70	0.008	0.04	< 0.001
Right mandible	D_mean	41.87 ± 4.45	41.17 ± 4.40	42.30 ± 4.10	< 0.001	0.08	< 0.001
Right mandible	D_median	42.33 ± 4.72	41.46 ± 4.74	42.99 ± 4.53	< 0.001	0.04	< 0.001
Body	D_mean	18.73 ± 4.11	18.65 ± 4.22	18.44 ± 3.74	0.24	0.002	0.09
Body	D_median	9.29 ± 6.13	9.84 ± 6.29	8.04 ± 5.01	< 0.001	< 0.001	< 0.001
Tongue	D_mean	43.00 ± 4.32	43.67 ± 4.24	42.74 ± 4.74	0.001	0.63	0.06
Tongue	D_median	42.27 ± 3.82	43.28 ± 3.92	41.82 ± 4.64	< 0.001	0.77	0.01
Left temporo-mandibular joint	D_mean	43.34 ± 8.59	43.03 ± 8.42	41.84 ± 8.48	0.07	< 0.001	0.02
Left temporo-mandibular joint	D_median	42.73 ± 9.07	42.72 ± 8.87	40.85 ± 7.31	0.46	0.06	< 0.001
Right temporo-mandibular joint	D_mean	42.50 ± 9.15	41.25 ± 8.88	41.93 ± 10.15	< 0.001	0.11	0.42
Right temporo-mandibular joint	D_median	42.13 ± 9.69	40.79 ± 9.03	41.58 ± 4.64	< 0.001	0.77	0.13
Plan	MU	1623 ± 302	1815 ± 206	1683 ± 146	< 0.001	0.56	0.004

P1 significant difference between clinical and automatic plans with warm start, P2 significant difference between clinical plans and automatic plans with cold start, P3 significant difference of automatic plans between warm start and cold start. Results with P < 0.05 indicated statistical significance and were labeled with bold

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