Retrospective analysis of the 18F-FDG PET/CT cutoff value for metabolic parameters was performed as a prediction model to evaluate risk factors for endometrial cancer

Table 4 ¹⁸ F-FDG PET/CT tumor markers in relation to surgical and histological tumor characteristics in 205 endometrial cancer patients

Parameters	Myometrial invasion		P	t	Myometrial invasion		P	t	Endocervical stromal involvement		P	t	Lymph node metastases		P	t
	No	Yes			< 50%	≥ 50%			No	Yes			No	Yes
No	83	122			66	56			177	28			122	83
SUVmax	1.58 ± 0.07	10.75 ± 0.21	< 0.01	34.59	10.29 ± 0.23	11.29 ± 0.36	< 0.05	2.383	1.92 ± 0.04	17.38 ± 0.65	< 0.01	54.12	1.72 ± 0.04	9.47 ± 0.34	< 0.01	27.41
SUVmean	1.46 ± 0.06	4.59 ± 0.09	< 0.01	26.45	4.08 ± 0.08	5.20 ± 0.12	< 0.01	7.659	1.43 ± 0.04	6.12 ± 0.19	< 0.01	35.23	1.44 ± 0.04	4.49 ± 0.16	< 0.01	21.27
MTV(ml)	17.55 ± 0.48	34.68 ± 0.45	< 0.01	25.46	31.73 ± 0.42	38.15 ± 0.55	< 0.01	9.378	13.13 ± 0.29	36.28 ± 1.51	< 0.01	24.77	16.03 ± 0.37	33.79 ± 0.85	< 0.01	21.34
ROC Area	1		< 0.01		0.8643				0.9881				0.9705
Std.Error	0.00				0.03153				0.008541				0.01449
95% CI	1	1			0.8025–0.9261		< 0.01		0.9714-1.000		< 0.01		0.9421–0.9989		< 0.01
Cutoff					19.6				20.54				24
Sensitivity					43.94				100				100
Specificity					100				92.86				92.77
TLG	25.71 ± 1.34	161.60 ± 4.57	< 0.01	24.05	129.60 ± 3.21	199.30 ± 6.14	< 0.01	10.50	18.84 ± 0.76	225.10 ± 11.58	< 0.01	41.86	23.02 ± 0.89	156.40 ± 7.06	< 0.01	22.55
ROC Area	1				0.9099				0.9895				0.9642
Std.Error	0.00				0.02520				0.01044				0.01771
95% CI	1	1			0.8605–0.9593		< 0.01		0.9690-1.000				0.9294–0.9989		< 0.01
Cutoff					126.3				84.80				49.38
Sensitivity					45.45				100				100
Specificity					100				96.43				93.98
Pathology	75	130			61	69			179	26			140	65
TP		122			61	56				26				65
TN		75			139	136				177				122
FP		0			5	0				2				18
FN		8			0	13				0				0
Sensitivity		93.85			100	81.16				100				100
Specificity		100			96.53	100				98.89				87.14
Accuracy		96.1			97.56	93.66				99.02				91.22
PPV		100			92.42	100				92.85				78.31
NPV		90.36			100	91.28				100				100

TP, true positive; TN, true negative; FP, false positive; FN, false negative; sensitivity; specificity; accuracy; PPV, positive predictive value; NPV, negative predictive value
p < 0.05 (2-tailed)

ISSN: 1748-717X