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Table 4 Protocol compliance of target volumes and organs at risk in the first and final submission

From: Quality assurance in a phase III, multicenter, randomized trial of POstmastectomy radioThErapy in Node posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a planning benchmark case

Target volumes/ Organs at risk

Dose parameters

First submission (n = 26)

Final submission (n = 26)

P value‡

Optimal No. (%)

Acceptable No. (%)

Optimal plus acceptable No. (%)

Optimal No. (%)

Acceptable No. (%)

Optimal plus acceptable No. (%)

PTVcw

V100%

7 (26.9)

11 (42.3)

18 (69.2)

11 (42.3)

14 (53.8)

25 (96.2)

0.016

Dmax/V120%

20 (76.9)

4 (15.4)

24 (92.3)

15 (57.7)

10 (38.5)

25 (96.2)

1.000

V110%

23 (88.5)

2 (7.7)

25 (96.2)

23 (88.5)

3 (11.5)

26 (100.0)

1.000

PTVsc + ax

V100%

15 (57.7)

5 (19.2)

19 (76.9)

13 (50.0)

13 (50.0)

26 (100.0)

0.031

Dmax/V120%

23 (88.5)

3 (11.5)

26 (100.0)

24 (92.3)

2 (7.7)

26 (100.0)

NA

V110%

23 (88.5)

2 (7.7)

25 (96.2)

22 (84.6)

3 (11.5)

25 (96.2)

1.000

PTVim

V100%

9 (34.6)

5 (19.2)

14 (53.8)

8 (30.8)

15 (57.7)

23 (88.5)

0.012

Dmax/V120%

24 (92.3)

2 (7.7)

26 (100.0)

25 (96.2)

1 (3.8)

26 (100.0)

NA

V110%

24 (92.3)

0

24 (92.3)

24 (92.3)

1 (3.8)

25 (96.2)

1.000

Heart

Dmean

4 (15.4)

15 (57.7)

19 (73.1)

2 (7.7)

24 (92.3)

26 (100.0)

0.016

V5Gy

17 (65.4)

3 (11.5)

20 (76.9)

22 (84.6)

3 (11.5)

25 (96.2)

0.125

LADCA

V40Gy

3 (11.5)

7 (26.9)

10 (38.5)

7 (26.9)

10 (38.5)

17 (65.4)

0.039

Ipsilateral lung

Dmean

11 (42.3)

8 (30.8)

19 (73.1)

14 (53.8)

8 (30.8)

22 (84.6)

0.250

V20Gy

12 (46.2)

13 (50.0)

25 (96.2)

17 (65.4)

9 (34.6)

26 (100.0)

1.000

V5Gy

9 (34.6)

8 (30.8)

17 (65.4)

11 (42.3)

13 (50.0)

24 (92.3)

0.016

Contralateral lung

V5Gy

20 (76.9)

4 (15.4)

24 (92.3)

21 (80.8)

4 (15.4)

25 (96.2)

1.000

Contralateral breast

Dmean

20 (76.9)

6 (23.1)

26 (100.0)

23 (88.5)

3 (11.5)

26 (100.0)

NA

Spinal Cord PRV

Dmax

22 (84.6)

3 (11.5)

25 (96.2)

26 (100.0)

0

26 (100.0)

1.000

Esophagus

Dmax

21 (80.8)

5 (19.2)

26 (100.0)

23 (88.5)

3 (11.5)

26 (100.0)

NA

Ipsilateral Brachial plexus

Dmax

13 (50.0)

11 (42.3)

24 (92.3)

9 (34.6)

15 (57.7)

24 (92.3)

1.000

Ipsilateral shoulder joint

V30

12 (46.2)

4 (15.4)

16 (61.5)

16 (61.5)

5 (19.2)

21 (80.8)

0.125

Thyroid gland

Dmean

15 (57.7)

9 (34.6)

24 (92.3)

16 (61.5)

9 (34.6)

25 (96.2)

1.000

Liver

V5

21 (80.8)

2 (7.7)

23 (88.5)

26 (100.0)

0

26 (100.0)

NA

Stomach

V5

10 (38.5)

4 (15.4)

14 (53.8)

18 (69.2)

6 (23.1)

24 (92.3)

0.002

  1. PTVcw, chest wall planning target volume; PTVsc + ax, supraclavicular fossa plus axilla levels I, II, III planning target volume; PTVim, internal mammary nodal planning target volume; NA, not available; LADCA, left anterior descending coronary artery; PRV, planning organs at risk volume; Vx, the relative volume irradiated to a minimum dose x Gy; Dmean, mean dose; Dmax, maximal dose
  2. ‡Comparison of the optimal plus acceptable rates between first and final submission
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Radiation Oncology

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