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Table 1 Dose constraints for target volumes and organs at risk in the POTENTIAL trial

From: Quality assurance in a phase III, multicenter, randomized trial of POstmastectomy radioThErapy in Node posiTive breast cancer with or without Internal mAmmary nodaL irradiation (POTENTIAL): a planning benchmark case

 

Dose parameters

Optimal

Acceptable

HFRT

CFRT

HFRT

CFRT

Target volumes

PTVcw*

Target volume coverage (V100%)

 ≥ 95%

 ≥ 95%

 ≥ 90%

 ≥ 90%

Hot spot dose

Dmax < 52 Gy

Dmax < 60 Gy

V120% < 1 cc

V120% < 1 cc

Dose uniformity (V110%)

 < 25%

 < 25%

 < 30%

 < 30%

PTVsc/PTVax*

Target volume coverage (V100%)

 ≥ 95%

 ≥ 95%

 ≥ 90%

 ≥ 90%

Hot spot dose

Dmax < 52 Gy

Dmax < 60 Gy

V120% < 1 cc

V120% < 1 cc

Dose uniformity (V110%)

 < 25%

 < 25%

 < 30%

 < 30%

PTVim for IMNI group

Target volume coverage (V100%)*

 ≥ 95%

 ≥ 95%

 ≥ 90%

 ≥ 90%

Target volume coverage (V90%)†

V40 ≥ 90%

V45 ≥ 90%

V40 ≥ 85%

V45 ≥ 85%

Hot spot dose*

Dmax < 52 Gy

Dmax < 60 Gy

V120% < 1 cc

V120% < 1 cc

Dose uniformity (V110%)*

 < 25%

 < 25%

 < 30%

 < 30%

Organs at risk

Heart (left-sided tumor)

Dmean

 < 8 Gy

 < 10 Gy

 < 10 Gy

 < 12 Gy

V5

 < 45%

 < 50%

 < 50%

 < 55%

Heart (right-sided tumor)

Dmean

 < 5 Gy

 < 6 Gy

 < 6 Gy

 < 8 Gy

V5

 < 30%

 < 35%

 < 35%

 < 40%

Left anterior descending coronary artery

V40

 < 20%

 < 20%

 < 25%

 < 25%

Right coronary artery

V40

 < 20%

 < 20%

 < 25%

 < 25%

Ipsilateral lung

Dmean

 < 15 Gy

 < 15 Gy

 < 16 Gy

 < 16 Gy

V20

 < 30%

 < 30%

 < 32%

 < 35%

V5

 < 55%

 < 55%

 < 60%

 < 60%

Contralateral lung

V5

 < 20%

 < 20%

 < 25%

 < 25%

Contralateral breast

Dmean

 < 5 Gy

 < 5 Gy

 < 8 Gy

 < 8 Gy

Spinal cord PRV

Dmax

 < 30 Gy

 < 40 Gy

 < 32 Gy

 < 45 Gy

Esophagus

Dmax

 < 48 Gy

 < 55 Gy

 < 50 Gy

 < 58 Gy

Brachial plexus

Dmax

 < 48 Gy

 < 55 Gy

 < 50 Gy

 < 58 Gy

Ipsilateral shoulder joint

V30

 < 30%

 < 30%

 < 35%

 < 35%

Thyroid gland

Dmean

 < 28 Gy

 < 30 Gy

 < 32 Gy

 < 35 Gy

Liver (left-sided tumor)

V5

 < 10%

 < 10%

 < 15%

 < 15%

Liver (right-sided tumor)

V5

 < 25%

 < 25%

 < 30%

 < 30%

Stomach (left-sided tumor)

V5

 < 25%

 < 25%

 < 30%

 < 30%

Stomach (right-sided tumor)

V5

 < 10%

 < 10%

 < 15%

 < 15%

  1. HFRT, hypofractionated radiotherapy; CFRT, conventional fractionated radiotherapy; PTVcw, chest wall planning target volume; PTVsc, supraclavicular planning target volume; PTVax, axilla planning target volume; PTVim, internal mammary nodal planning target volume; IMNI, internal mammary nodal irradiation; Vx, the relative volume irradiated to a minimum dose x Gy; Dmax, maximal dose; Dmean, mean dose; LADCA, left anterior descending coronary artery; RCA, right coronary artery; PRV, planning organs at risk volume
  2. *Patients treated with photon-based intensity modulated technique to all target volumes
  3. †Patients treated with electron beam therapy to the chest wall ± IMN
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Radiation Oncology

ISSN: 1748-717X

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