Table 3 Treatment-related toxicities of proton and carbon-ion radiotherapy combined with chemotherapy
Characteristics | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|---|
Acute | Â | Â | Â | Â | Â |
Pulmonary | Â | Â | Â | Â | Â |
 Cough | 4 (20%) | 1 (5%) | 0 | 0 | 0 |
 Pneumonitis | 1 (5%) | 3 (15%) | 0 | 0 | 0 |
Gastrointestinal | Â | Â | Â | Â | Â |
 Esophagitis | 12 (60%) | 6 (30%) | 0 | 0 | 0 |
General | Â | Â | Â | Â | Â |
 Weight loss | 3 (15%) | 0 | 0 | 0 | 0 |
 Dermatitis | 9 (45%) | 1 (5%) | 0 | 0 | 0 |
Hematologic | Â | Â | Â | Â | Â |
 Leucopenia | 3 (15%) | 2 (10%) | 5 (25%) | 3 (15%) | 0 |
 Neutropenia | 1 (5%) | 6 (30%) | 0 | 6 (30%) | 0 |
 Anemia | 14 (70%) | 5 (25%) | 0 | 0 | 0 |
 Thrombocytopenia | 4 (20%) | 0 | 0 | 0 | 0 |
Late | Â | Â | Â | Â | Â |
 Pulmonary | 10 (50%) | 1 (5%) | 0 | 0 | 0 |
 Tracheal | 0 | 0 | 1 (5%) | 0 | 0 |
 Esophageal | 1 (5%) | 3 (15%) | 1 (5%) | 0 | 0 |
 Dermal | 3 (15%) | 0 | 0 | 0 | 0 |